Cartridge

Abstract

The present invention relates to a cartridge for shielding contents of a barrel of a syringe, the cartridge comprising: a housing; wherein the housing comprises an opening through which the tip, barrel and flange of the syringe can be introduced into the housing; a chamber having a first portion for receiving the barrel of the syringe and a second portion for receiving the flange of the syringe; and an aperture opposite the opening through which the tip of the syringe can project when the syringe is introduced into the housing.

Description

Technical Field

[0001] The present invention relates to packaging. In particular, the present invention provides a box that conceals the contents of the barrel of a syringe. Background Art

[0002] Blind clinical trials eliminate patient and / or practitioner bias and may therefore limit potential placebo effects. To meet the requirements of a blind clinical trial, it is essential that the recipient of the drug and the practitioner who typically administers the drug do not know whether they are receiving or administering a placebo or drug. Trials in which neither the practitioner nor the patient know whether they are receiving or administering a placebo or drug are called "double-blind."

[0003] Current possibilities for drug / placebo blinding include the use of: vial ampoule blinding solutions, such as opaque vials containing drug or placebo; plastic syringe blinding systems, such as blackened syringe barrels or plastic syringe caps; and makeshift systems such as covering the vial or syringe with a cloth.

[0004] However, in many of the above blinding possibilities, the placebo or drug may need to be packaged differently, or poured into new blackened or opaque packaging for the trial, which may be inconvenient and expensive for the user. In addition, the temporary system may fall off during administration of the placebo or drug, and thus the effectiveness of the blinded clinical trial may be compromised.

[0005] Therefore, there is a need for an effective syringe shielding box for blinded clinical trial testing that is user-friendly, effective, easy to manufacture, and economical. Summary of the invention

[0006] According to the present invention, a box is provided for shielding the contents of the barrel of a syringe, the box comprising: a housing; wherein the housing comprises an opening through which the tip, barrel and flange of the syringe can be introduced into the housing; a chamber having a first portion for receiving the barrel of the syringe and a second portion for receiving the flange of the syringe; and an orifice, which is opposite to the opening, through which the tip of the syringe can protrude when the syringe is introduced into the housing.

[0007] As used herein, the term "syringe" refers to the assembled plunger, barrel, flange, and tip of a "syringe," wherein the tip may include a needle and / or a protective cover (i.e., a cap). Thus, it will be understood that the term "syringe" may refer to a syringe that includes a needle and / or a protective cover (i.e., a cap) on the tip. It will also be understood that the term "syringe" refers to any syringe known in the art (including, for example, a prefilled syringe).

[0008] The box may include at least one wing portion, which can be moved from a first (e.g., unlocked) configuration in which the at least one wing portion is not engaged with the syringe to a second (e.g., locked) configuration in which the at least one wing portion is engaged with the flange of the syringe after the syringe (i.e., the tip, barrel and flange) is introduced into the housing, thereby securing the syringe within the housing.

[0009] Preferably, the box includes at least two wing portions, which can be moved from a first (e.g., unlocked) configuration in which the at least two wing portions are not engaged with the syringe to a second (e.g., locked) configuration in which the at least two wing portions are engaged with the flange of the syringe after the syringe (i.e., the tip, barrel and flange) are introduced into the housing, thereby fixing the syringe in the housing.

[0010] After the syringe (i.e., tip, barrel, and flange) is introduced into the housing, the barrel of the syringe is located within the first portion of the chamber, the flange of the syringe is located within the second portion of the chamber, the tip of the syringe protrudes through the orifice so that the tip of the syringe is located outside the housing, and the plunger of the syringe is located outside the opening of the housing. Therefore, as used herein, the phrase "syringe within the housing" or "syringe in the housing" refers to the syringe in the above-described arrangement.

[0011] To facilitate the introduction of the tip, barrel and flange of the syringe into the housing, one or more fin portions should be in (or moved to) a first (e.g., unlocked) configuration such that they are positioned within the opening and not engaged with the syringe. After the tip, barrel and flange of the syringe are introduced into the housing and the tip subsequently protrudes through the orifice of the housing, the fin portions may be in (i.e., moved to) a second (e.g., locked) configuration in which one or more fin portions engage the flange of the syringe, thereby securing the syringe within the housing.

[0012] As used herein, the phrase "securing the syringe within the housing" means substantially preventing the syringe from moving back through the opening of the housing. In other words, in the second (e.g., locked) configuration, the fin portion prevents the tip, barrel, and flange of the syringe from being withdrawn back through the opening of the housing, thereby preventing the box from falling off the syringe during use (e.g., during administration of the contents of the barrel of the syringe to a patient). A user (e.g., a syringe user) can move the fin portion between the first (e.g., unlocked) configuration and the second (e.g., locked) configuration after the tip, barrel, and flange of the syringe are introduced into the housing.

[0013] It will be appreciated that one or more wing parts comprise a first end and a second end. The first end of the wing part or each wing part can be attached to the housing in a position substantially adjacent to the opening of the housing. Preferably, the first end of the wing part or each wing part is attached to the housing on an edge or a margin of the opening of the housing. Preferably, the first end of the wing part or each wing part is a continuation of the housing (that is, formed by identical continuous sheet of material). When box of the present invention comprises at least two wing parts, preferably, the wing part is evenly distributed on / around an edge or a margin of the opening of the housing.

[0014] The opening of the housing can be roughly square or oval. Where the box of the present invention comprises at least one wing portion or at least two wing portions, the wing portion or each wing portion can be positioned on the side of the square or oval opening of the housing (i.e., on the side / edge of the opening). Where the box of the present invention comprises at least two wing portions, the wing portions are preferably positioned on the opposite sides of the square or oval opening of the housing (i.e., on the opposite sides / edge of the opening).

[0015] Preferably, the one or more fin portions are sized so that when in the second (e.g., locked) configuration, the second end of the fin portion or each fin portion abuts the flange of the syringe, thereby fixing the syringe in the housing. The one or more fin portions can provide resistance to the syringe moving back through the opening of the housing, thereby preventing the box from falling off the syringe during use. However, it will be understood that if necessary (i.e., after using the syringe), the user will be able to remove the syringe from the box by moving the fin portion between the second (e.g., locked) configuration to the first (e.g., unlocked) configuration and moving the tip, barrel and flange of the syringe out of the opening.

[0016] The second portion of the chamber may include a recess (e.g., disposed opposite the opening) that is ergonomically designed (e.g., semicircular) to engage with the fingers (e.g., index and middle fingers) of a user (e.g., a syringe user). The recess may provide a rest whereby the user's fingers may rest during use of the syringe (e.g., during administration of the contents of the barrel of the syringe to a patient). The recess may be shaped and sized so that they complement the user's fingers, thereby facilitating use of the syringe.

[0017] The second portion of the chamber may include a plunger recess (e.g., disposed adjacent to the opening) that is ergonomically designed (e.g., semicircular) to allow the plunger of the syringe to be (e.g., fully) depressed. It will be appreciated that for the syringe to be used (e.g., to administer the contents of the barrel of the syringe to a patient), the user (e.g., a syringe user) presses the plunger of the syringe downward until the plunger reaches a desired position in the barrel. The plunger recess may be shaped and sized such that they allow the plunger of the syringe to be (e.g., fully) depressed. Thus, when the syringe is within the housing, the entire contents of the barrel of the syringe may be administered.

[0018] Preferably, the housing is at least substantially opaque. A substantially opaque housing enables the contents of the barrel of the syringe to be obscured or partially obscured by a user (e.g., a syringe user), a practitioner, a patient, etc. after the syringe (i.e., the tip, barrel, and flange) are introduced into the housing.

[0019] As used herein, the phrase obscured or partially obscured means that a user (e.g., a syringe user), a practitioner, or a patient, etc., cannot identify the contents of a syringe (e.g., a syringe barrel) in a box of the present invention (e.g., by reading a label), and / or cannot distinguish between a box of the present invention that includes a syringe having a first substance therein (e.g., in the barrel of a syringe) and a box of the present invention that includes a syringe having a second (i.e., different) substance therein (e.g., in the barrel of a syringe). However, it will be understood that it is still possible for a user (e.g., a syringe user), a practitioner, or a patient, etc., to see the barrel, flange, and / or label of a syringe within a box of the present invention, but not be able to identify or distinguish between the substances therein.

[0020] Preferably, the housing is substantially complementary in shape to the syringe (e.g., a T-shaped prism). When the housing is substantially complementary in shape to the syringe, use of the syringe within the housing (e.g., administering the contents of the cartridge to a patient) is simple and can be comparable to use of a bare syringe. However, it will be appreciated that the housing can be any shape (e.g., a cuboid, e.g., a triangular prism).

[0021] The opening of the housing is sized so that the tip, barrel and flange of the syringe can be introduced into the housing through the opening. The first portion of the chamber is sized to receive the barrel of the syringe and the second portion of the chamber is sized to receive the flange of the syringe. The orifice is sized so that when the syringe is introduced into the housing, the tip of the syringe can protrude through the orifice.

[0022] Preferably, the housing is sized such that after the syringe is introduced into the housing, movement of the syringe (i.e., within the housing) is substantially prevented. Movement of the syringe within the housing may impede use of the syringe (e.g., administering the contents of the barrel of the syringe to a patient). Therefore, it is preferred that movement of the syringe (i.e., within the housing) is substantially prevented to facilitate use of the syringe.

[0023] The box can be formed by identical continuous sheets of material. The continuous sheets of material can be kept in shape with adhesive (e.g., glue). Adhesive (e.g., glue) can be present on the tab portion of the continuous sheet of material. Preferably, the material used to form the box is a paper-based material, such as cardboard, such as paperboard. The box can be produced using conventional manufacturing procedures and is easy to manufacture.

[0024] The box may have a syringe disposed therein. The syringe may be a prefilled syringe. The syringe may contain a substance (e.g., in a barrel). The substance may be a drug or a healthcare product. The product may be a liquid or a powder. However, it will be appreciated that the powder must be dissolved in a solution before being administered to a patient. Preferably, the barrel of the syringe is located in a first portion of the chamber, the flange of the syringe is located in a second portion of the chamber, the tip of the syringe protrudes through the orifice so that the tip of the syringe is located outside the housing, and the plunger of the syringe is located outside the opening of the housing. Preferably, the syringe is sized so that after the syringe is introduced into the housing, movement of the syringe (i.e., in the housing) is substantially prevented.

[0025] In another aspect of the invention, a box is provided for shielding the contents of a syringe barrel. The box shields the contents of a syringe barrel when administered to a patient during clinical trial testing (e.g., clinical trial phase 3 and phase 4 studies).

[0026] In another aspect of the invention there is provided a blank for forming a box according to any statement set out herein.

[0027] In another aspect of the present invention, a blank for a box is provided, the blank comprising: a single continuous sheet of material, the single sheet comprising: a first section, the first section forming a back panel of the box; a second section, the second section forming a first side panel of the box; a third section, the third section forming a front panel of the box; and a fourth section, the fourth section forming a second side panel of the box; wherein the first section is joined to the second section along a fold line and / or a perforated fold; wherein the second section is joined to the third section along a fold line and / or a perforated fold; wherein the third section is joined to the fourth section along a fold line and / or a perforated fold; at least one flap, the at least one flap extending longitudinally from one or more of the sections in a direction substantially the same as at least one of the fold lines and / or the perforated folds; and a tab, the tab extending longitudinally from the first section in a direction substantially perpendicular to at least one of the fold lines and / or the perforated folds.

[0028] The blank may also include at least two cuts, a first cut that crosses the second section and a portion of the third section in a direction substantially perpendicular to at least one of the folding lines and / or perforated creases, and a second cut that crosses the fourth section and a portion of the third section in a direction substantially perpendicular to at least one of the folding lines and / or perforated creases.

[0029] The blank may also include recesses (eg, cutouts) in the first section and the third section.

[0030] The blank may be folded along the fold lines and / or perforated folds such that the tab contacts and is attached to the underside of the fourth section with an adhesive, thereby joining the tab and the fourth section together.

[0031] The blank may be folded along another fold line and / or perforated fold such that a portion of the fourth section contacts and is adhesively attached to a portion of the first section, thereby joining a portion of the first section to a portion of the fourth section.

[0032] It will be appreciated that the skilled person will be able to fold the blank along the fold lines and / or perforated creases to form a box.

[0033] In another aspect of the invention there is provided a method of making a box, the method comprising folding a blank as described herein.Advantageously, the box is easy to build up from the blank. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Embodiments of the present invention will now be described, by way of example only, with reference to the accompanying drawings, in which:

[0035] Figure 1 is a perspective view of a box according to the present invention;

[0036] Figure 2 yes Figure 1 An alternative stereogram of a box;

[0037] Figure 3 yes Figure 1 An alternative stereogram of a box;

[0038] Figure 4 is a perspective view of an assembled syringe that may be disposed within a cartridge according to the present invention;

[0039] Figure 5 yes Figure 1 View of a blank for a box.

[0040] Figure 1 , Figure 2 and Figure 3 A cassette for shielding the contents of a barrel of a syringe according to one aspect of the present invention is illustrated. Figure 2 and Figure 3 The diagram shows Figure 1 Different views of the same box. Figure 5 A blank for a box according to one aspect of the invention is illustrated.

[0041] The box 100 includes a housing 101, a first wing portion 110 and a second wing portion 120, and the box 100 is formed of the same continuous sheet of paper (e.g., cardboard) or other suitable material (e.g., paperboard). The continuous sheet of paper (e.g., cardboard) or other suitable material (e.g., paperboard) is substantially opaque. The box 100 is capable of accommodating a syringe (including, for example, a prefilled syringe) (see Figure 4 ), the syringe containing a liquid pharmaceutical product, such as a drug or a placebo, therein (i.e., within the barrel).

[0042] The housing 101 has an oval opening 102 at one end of the housing 101, a syringe (i.e., an assembled syringe, see e.g. Figure 4 ) can be introduced into the housing 101 through the opening 102; a chamber having a first portion 103 for receiving the barrel of the syringe and a second portion 104 for receiving the flange of the syringe; and an orifice 105, which is opposite to the opening 102, and when the syringe is introduced into the housing 101, the tip of the syringe can protrude through the orifice 105.

[0043] The second portion 104 of the chamber has semicircular recesses 107a and 107b, which are disposed in the wall of the second portion 104 of the chamber opposite the opening 102 and are located on both sides of the entrance to the first portion 103 of the chamber. The recesses 107a and 107b are complementary in shape to the index and middle fingers of a user and are sized to fit the index and middle fingers of a user. The second portion 104 of the chamber has semicircular plunger recesses 106a and 106b, which are disposed adjacent to the opening 102 and on opposite sides of the opening 102, and the recesses 106a and 106b are sized to allow the plunger of the syringe to be fully depressed.

[0044] The opening 102 is sized so that the tip, barrel and flange of the syringe can be introduced into the housing through the opening 102. The first portion 103 of the chamber is sized to receive the barrel of the syringe, and the second portion 104 of the chamber is sized to receive the flange of the syringe. The orifice 105 is sized so that when the syringe is introduced into the housing 101, the tip of the syringe (including the needle and / or the protective cap) can protrude through the orifice 105.

[0045] It will be understood that the two wing portions 110 and 120 are continuations of the housing 101, formed from the same continuous sheet of paper (e.g., cardboard) or another suitable material (e.g., paperboard). The two wing portions 110 and 120 each have a first end 110a / 120a and a second end 110b / 120b. The first ends 110a / 120a of the two wing portions 110 and 120 are attached to the housing 101 on opposite sides at the edge of the opening 102. Figure 1 As shown in FIG. 1 , when in the first (eg, unlocked) configuration, the two tab portions 110 and 120 are arranged such that they are positioned within the opening 102 and are not engaged with the syringe.

[0046] Before assembling the syringe (i.e., tip, barrel, and flange) Figure 1After the cartridge 100 is introduced into the housing 101 (not shown in FIG), the two fin portions 110 and 120 can be moved from a first (e.g., unlocked) configuration to a second (e.g., locked) configuration in which the second end 110b / 120b abuts against the flange of the syringe, thereby securing the syringe in the housing 101. The two fin portions 110 and 120 are sized so that when in the second (e.g., locked) configuration, the second end 110b / 120b provides resistance to the syringe moving back through the opening 102 of the housing 101, thereby preventing the cartridge 100 from falling off the syringe during use. However, it will be understood that if necessary (i.e., after using the syringe), the user will be able to remove the syringe from the housing 101 by moving the two fin portions 110 and 120 between the second (e.g., locked) configuration and the first (e.g., unlocked) configuration and moving the tip, barrel and flange of the syringe out of the opening 102.

[0047] Figure 4 300 is a schematic diagram of an assembled syringe that may be provided in a cassette according to the present invention. The syringe 300 comprises a barrel 301 , a flange 302 , a plunger 303 and a tip 304 with a needle 305 .

[0048] Figure 5 A blank 200 is illustrated. Figure 5 The blank shown in the figure is configured to form Figure 1 , Figure 2 and Figure 3 The box 100 shown in .

[0049] The blank 200 comprises a first section 201 forming a rear panel of the box, a second section 202 forming a first side panel of the box, a third section 203 forming a front panel of the box, and a fourth section 204 forming a second side panel of the box. The first section 201 is joined to the second section along fold lines 208 and 209. The second section 202 is joined to the third section 203 along fold line 213 and perforation fold 214. The third section 203 is joined to the fourth section 204 along fold line 220 and perforation fold 221.

[0050] The flap 211 extends longitudinally from the second section 202 in substantially the same direction as the fold line 208 and is joined to the second section 202 along the fold line 212. The flap 223 extends longitudinally from the fourth section 204 in substantially the same direction as the fold line 220 and is joined to the fourth section along the fold line 224.

[0051] The tab 205 extends longitudinally from the first section 201 in a direction generally perpendicular to the perforation fold 206 and is joined to the first section 201 along the perforation fold 206 .

[0052] The first section 201 is recessed to form a plunger recess 207. The third section 203 is recessed to form a plunger recess 219 which is shaped and sized the same as the plunger recess 207.

[0053] The second section 202 includes a cut 210 that traverses the second section 202 in a direction generally perpendicular to the fold line 209 (from the fold lines 209 / 208 to the perforation crease 214 / fold line 213 ).

[0054] The third section 203 has two parallel fold lines 215, 216 extending longitudinally from the edge of the third section 203 along the third section 203 for approximately more than half the length of the third section 203. A semicircular cutout 217 extends from the fold line 215 to the second section 202 (where the perforated fold 214, the cutout 210, and the fold line 213 converge) in a direction approximately perpendicular to the fold line 215. A semicircular cutout 218 extends from the fold line 216 to the fourth section 204 (where the perforated fold 221, the cutout 222, and the fold line 220 converge) in a direction approximately perpendicular to the fold line 216.

[0055] The fourth section 204 includes a cut 222 that traverses the fourth section 204 in a direction generally perpendicular to the fold line 220 (traversing from an edge of the fourth section 204 to the perforation crease 221 / fold line 220 ).

[0056] It will be appreciated that the blank 200 may be assembled by a skilled artisan to form Figure 1 An example of a method for assembling the blank 200 is described below.

[0057] To assemble the blank 200 into the box 100, the blank is folded along the folding lines and / or perforated folds so that the tab 205 contacts the lower side of the fourth section 204 and is attached to the lower side of the fourth section 204 with an adhesive, thereby joining the tab 205 and the fourth section 205 together.

[0058] The blank 200 is then folded along another fold line and / or perforated fold so that a portion of the fourth section 204 contacts a portion of the first section 201 and is attached to a portion of the first section 201 with an adhesive, thereby joining a portion of the first section 201 to a portion of the fourth section 204.

[0059] The second section 202 is then moved perpendicularly to the first section 201. The third section 203 is moved synchronously with the second section 202, so that a portion of the third section 203 is parallel to the first section 201, and a portion of the third section 203 (located between the folding line 216 and the perforation fold 221) is perpendicular to the first section 201.

[0060] A portion of the second segment 202 (i.e., between the folding line 209 and the perforated crease 214) and a portion of the third segment 203 (i.e., between the folding line 215 and the perforated crease 214) are then folded along the folding lines 215, 209 and the perforated crease 214 toward the lower side of the first segment 201, so that a portion of the second segment 202 contacts the first segment 201 and a portion of the third segment 203 is perpendicular to the first segment 201.

[0061] The opening 102 is formed by the edges of the first section 201, the second section 202, the third section 203 and the fourth section 204. The flap 211 and the flap 223 form flap portions 110 and 120 located on opposite sides of the opening 102, respectively.

[0062] The first portion 103 of the chamber is formed by a portion of the lower side of the first section 201, the lower side of a portion of the third section 203 perpendicular to the first section 201, and a portion of the third section 203 parallel to the first section 201. The orifice 105 is formed by a portion of the edge of the first section 201, a portion of the edge of the third section 203 perpendicular to the first section 201, and a portion of the edge of the third section 203 parallel to the first section 201 (located between the fold line 125 and the fold line 216).

[0063] The second portion 104 of the chamber is formed by portions of the lower sides of the first section 201 , the second section 202 , the third section 203 and the fourth section 204 .

[0064] Semicircular cutouts 217 and 218 form recesses 107a and 107b disposed in the wall of chamber second portion 104. Recesses 207 and 219 form plunger recesses 106a and 106b disposed adjacent to opening 102 and on opposite sides thereof.

Claims

1. A box for covering the contents of a syringe barrel, the box comprising: case; wherein the housing includes an opening through which the tip, barrel and flange of the syringe can be introduced into the housing; a chamber having a first portion for receiving the barrel of the syringe and a second portion for receiving the flange of the syringe; and an aperture, opposite the opening, through which the tip of the syringe can protrude when the syringe is introduced into the housing.

2. The box according to claim 1 includes at least one wing portion, which can be moved from a first (e.g., unlocked) configuration in which the at least one wing portion is not engaged with the syringe to a second (e.g., locked) configuration in which the at least one wing portion is engaged with the flange of the syringe after the syringe is introduced into the housing, thereby fixing the syringe in the housing.

3. The box according to claim 1 or claim 2 comprises at least two wing parts, and after the syringe is introduced into the housing, the at least two wing parts can be moved from a first (e.g., unlocked) configuration in which the at least two wing parts are not engaged with the syringe to a second (e.g., locked) configuration in which the at least two wing parts are engaged with the flange of the syringe, thereby fixing the syringe in the housing.

4. A box according to claim 2 or claim 3, wherein The tab portion is sized such that when in the second (eg, locked) configuration, an end of the tab portion abuts the flange of the syringe, thereby securing the syringe within the housing.

5. A cartridge according to any preceding claim, wherein The second portion of the chamber includes a recess (eg, disposed opposite the opening) that is ergonomically designed (eg, semicircular) to engage with a user's fingers (eg, index and middle fingers).

6. A cartridge according to any preceding claim, wherein The second portion of the chamber includes a plunger recess (eg, disposed adjacent to the opening) that is ergonomically designed (eg, semicircular) to allow the plunger of the syringe to be (eg, fully) depressed.

7. A cartridge according to any preceding claim, wherein: The housing is at least substantially opaque.

8. A cartridge according to any preceding claim, wherein The housing is substantially complementary in shape to the syringe (eg, a T-shaped prism).

9. A cartridge according to any preceding claim, wherein: The housing is sized such that movement of the syringe is substantially prevented after the syringe is introduced into the housing.

10. A box according to any preceding claim, formed from the same continuous sheet of material.

11. The cartridge according to claim 10, wherein The continuous sheet of material is held in shape by an adhesive.

12. A box according to any preceding claim, formed from cardboard.

13. A cassette according to any preceding claim having a syringe disposed therein.

14. The cartridge according to claim 13, wherein The barrel of the syringe is located within the first portion of the chamber, the flange of the syringe is located within the first portion of the chamber, the tip of the syringe protrudes through the orifice so that the tip of the syringe is located outside the housing, and the plunger of the syringe is located outside the opening of the housing.

15. Use of a cassette according to any preceding claim for concealing the contents of the barrel of a syringe.

16. The use according to claim 15, wherein The box shields the contents of the barrel of a syringe when administered to a patient during clinical trial testing.

17. A blank for forming a pack according to any preceding claim.

18. A blank for a box, the blank comprising: A single continuous sheet of material, a single sheet comprising: a first section forming a rear panel of the box; a second section forming a first side panel of the box; a third section forming a front panel of the box; and a fourth section forming a second side panel of the box; wherein the first section is joined to the second section along a folding line and / or a perforated fold; wherein the second section is joined to the third section along a folding line and / or a perforated fold; wherein the third section is joined to the fourth section along a folding line and / or a perforated fold; at least one flap extending longitudinally from one or more of the segments in substantially the same direction as at least one of the fold line and / or the perforation crease; and A tab extends longitudinally from the first section in a direction generally perpendicular to at least one of the fold line and / or the perforation crease.

19. The blank according to claim 18 further includes at least two cuts, a first cut that crosses the second segment and a portion of the third segment in a direction substantially perpendicular to the folding line and / or at least one of the perforated creases, and a second cut that crosses the fourth segment and a portion of the third segment in a direction substantially perpendicular to the folding line and / or at least one of the perforated creases.

20. A product comprising a blank according to claim 18 or 19, wherein: The blank is folded along the fold lines and / or the perforated folds such that the tab contacts and is adhesively attached to the underside of the fourth section, thereby joining the tab and the fourth section together.

21. A product comprising a blank according to any one of claims 18 to 20, wherein: The blank is folded along another fold line and / or perforated fold so that a portion of the fourth section contacts a portion of the first section and is attached to a portion of the first section with an adhesive, thereby joining a portion of the first section to a portion of the fourth section.

22. A method of making a box, the method comprising folding a blank according to any one of claims 17 to 21.

23. A cassette substantially as herein described with reference to Figures 1 to 3.

24. A blank substantially as herein described with reference to Figure 5.

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