Total nutrient emulsion suitable for tumor patients and preparation method thereof

Abstract

The invention belongs to the technical field of special medical food, and particularly relates to a total nutrient emulsion specially designed for tumor patients and a preparation method thereof. The emulsion comprises proteins, fat, carbohydrates, dietary fibers, various vitamins, minerals, sweeteners, omega-3 fatty acids and probiotics. Omega-3 fatty acid and probiotics are added into the emulsion, so that the immunotherapy effect of tumors can be adjusted, the side effects of certain anti-cancer drugs are reduced, and the living quality of patients is improved; by adopting secondary emulsification and high-temperature instantaneous sterilization technologies, the loss of effective components of the prepared emulsion is lower than 5%, and the emulsion is still stable after being placed at normal temperature for 18 months. The invention is suitable for tumor patients over 10 years old, and can be used as a single or partial nutrition source for direct oral administration or tube feeding nutrition supplement.

Description

Technical Field

[0001] The present invention relates to the technical field of special medical food, in particular to a complete nutritional emulsion specially designed for tumor patients and a preparation method thereof. The emulsion is intended to meet the special nutritional needs of tumor patients, improve their nutritional status and enhance their quality of life. Background Art

[0002] FSMP, or special medical purpose formula food, is a professional food designed to meet the needs of people with specific diseases or nutritional requirements. It provides targeted nutritional support based on the patient's nutritional needs and disease status, helping to promote recovery, improve nutritional status and improve quality of life. FSMP is widely used in hospitals, rehabilitation centers and home care, providing comprehensive nutritional solutions for patients recovering from surgery, malnutrition, metabolic disorders and specific diseases. Through scientific formulas and precise nutritional ratios, FSMP has become an important bridge between medical treatment and nutrition, helping patients recover their health.

[0003] Cancer patients often suffer from intestinal flora imbalance and malnutrition due to the disease itself and anti-cancer treatment (such as radiotherapy and chemotherapy), which in turn affects their quality of life and treatment effect. Complete nutritional emulsion is an important means of nutritional supplementation. It is rich in key nutrients such as high-quality protein, essential fatty acids, vitamins and minerals, and provides comprehensive and balanced nutritional support. It can meet the high nutritional needs of cancer patients during treatment, enhance the body's immunity, promote tissue repair, and have significant benefits for recovery. In addition, complete nutritional emulsion is easy to digest and absorb, reduces gastrointestinal burden, helps to improve common problems such as loss of appetite and malnutrition in cancer patients, improves quality of life, and provides strong support for anti-cancer treatment.

[0004] Intestinal flora can stimulate the development and activation of immune cells, enhance immune response, reduce inflammatory response, and thus fight against the occurrence and development of tumors. Tumor patients often suffer from intestinal flora imbalance after receiving treatments such as radiotherapy and chemotherapy. The restoration of intestinal microbiota in cancer patients can stabilize and enhance intestinal barrier function, and promote anti-cancer, anti-inflammatory, and anti-mutation effects. Probiotics can correct flora imbalance, promote the repair of intestinal mucosal cells, increase intestinal peristalsis, and improve digestion and absorption functions. In addition, omega-3 fatty acids can also reduce the side effects of certain anticancer drugs, improve the effect of chemotherapy, and improve the quality of life of patients.

[0005] Complete nutritional formula emulsion products are complex multiphase liquid dispersion systems, and the stability of nutrients is affected by factors such as the source of raw materials, mineral dosage form, pH value and production process. On the one hand, existing enteral nutrition emulsions are often not very stable. After mixing with proteins, mineral ions (such as calcium ions, magnesium ions, zinc ions, copper ions, etc.) greatly affect the properties of proteins, resulting in instability such as flocculation, creaming, and aggregation of the emulsion. The product is prone to nutrient loss during storage. On the other hand, it has a poor taste, a single nutritional function, and lacks specific nutrients. Summary of the invention

[0006] The object of the present invention is to provide an enteral complete nutrition emulsion suitable for tumor patients, the emulsion comprising protein, fat, carbohydrate, dietary fiber, various vitamins, minerals, sweetener, ω-3 fatty acids and probiotics. The emulsion is added with ω-3 fatty acids, probiotics, etc., which can improve the immune response of tumor patients, reduce the toxic and side effects of tumor treatment, and improve the quality of life of patients; natural non-caloric sweeteners are used as flavoring agents to improve the taste of emulsifiers; secondary emulsification and high-temperature instantaneous sterilization technology are used, and the loss of effective ingredients of the prepared emulsion is less than 5%, and the emulsion remains stable after being placed at room temperature for 18 months.

[0007] In order to achieve the above-mentioned invention object, the present invention adopts the following technical solutions: The first aspect of the present invention provides an enteral complete nutritional emulsion suitable for tumor patients, which includes the following components: protein, fat, carbohydrates, dietary fiber, complex vitamins (including vitamins A, D3, E, K1, B group), minerals (including calcium, phosphorus, magnesium, iron, zinc, selenium, etc.), sweeteners, other nutrients (including ω-3 fatty acids, probiotics), etc.

[0008] Each 100mL contains: Protein: 5-7g, preferably high-quality protein, such as one or more of whey protein, soy protein, fish protein, etc.

[0009] Fat: 5-7g, preferably one or more of vegetable oils (including soybean oil, peanut oil, linseed oil, olive oil, coconut oil, rapeseed oil, corn oil, camellia oil, walnut oil, etc.) and animal oils (including fish oil, milk fat, etc.). Vegetable oils and animal oils rich in omega-3 fatty acids are preferred, such as corn oil, linseed oil, olive oil, and fish oil.

[0010] Carbohydrates: 8-12 g, preferably carbohydrates are composed of one or more of oligosaccharides, glucose, fructose, plant polysaccharides, etc. Oligofructose and maltodextrin are preferred.

[0011] Dietary fiber: 0.5-10g, preferably 8-10g. The dietary fiber includes but is not limited to one or more of pectin, xanthan gum, carrageenan, microcrystalline cellulose, etc., preferably, it is composed of carrageenan, microcrystalline cellulose and xanthan gum. More preferably, the dietary fiber is composed of 3g of carrageenan, 3g of microcrystalline cellulose and 2g of xanthan gum.

[0012] The preferred vitamin content is: Vitamin A (µg RE) 10-225; Vitamin D3 (µg) 0.2-3.5; Vitamin E (mg α-TE) 0.2-2; Vitamin K1 (µg) 2-5; Vitamin B1 (mg) 0.02-1; Vitamin B2 (mg) 0.02-1; Vitamin B6 (mg) 0.02-1; Vitamin B12 (µg) 0.05-1; Niacinamide (mg) 0.05-1; Pantothenic acid (mg) 0.1-5; Biotin (µg) 0.5-5; Folic acid (µg) 10-50; Vitamin C (mg) 3-20.

[0013] The preferred mineral content is sodium (mg) 20-200; potassium (mg) 30-300; copper (µg) 20-200; magnesium (mg) 5-150; iron (mg) 0.2-3; zinc (mg) 0.1-2.2; manganese (µg) 6-600; calcium (mg) 20-150; phosphorus (mg) 20-100; iodine (µg) 2-50; chlorine (mg) 1-200; selenium (µg) 1-20.

[0014] The preferred sweetener is one or more combinations of stevioside, monk fruit sugar, liquorice, xylitol, and erythritol, and the added amount is 0.1-2g. Preferably, the added amount of the sweetener is 0.5g. Further preferably, the sweetener consists of stevioside and erythritol.

[0015] Other preferred nutrients include ω-3 fatty acids (mg) 250-2000, taurine (mg) 5-20, L-carnitine (mg) 0.5-20, probiotic composition (10 9 CFU) 10-1000.

[0016] Preferred probiotics are Lactobacillus acidophilus and Bifidobacterium, wherein Lactobacillus acidophilus accounts for 40-70% of the total probiotics.

[0017] Preferably, the enteral complete nutrition emulsion suitable for tumor patients contains the following nutrients per 100 mL of emulsion: 5-7 g protein, 5-7 g fat, 8-12 g carbohydrate, 8-10 g dietary fiber, 0.5 g sweetener, 1000 mg ω-3 fatty acid, 500×10 probiotic composition. 9CFU, vitamin A 50 µg RE, vitamin D3 1-2 µg, vitamin E 1-2 mgα-TE, vitamin K1 3-5 µg, vitamin B1 0.2 mg, vitamin B2 0.2 mg, vitamin B6 0.25 mg, vitamin B12 0.25 µg, niacinamide 0.8-1mg, pantothenic acid 0.6-1 mg, biotin 4-5 µg, folic acid 35-40 µg, vitamin C15 mg, taurine 10 mg, L-carnitine 10 mg, sodium 90-120 mg, potassium 160-200 mg, copper 70-90 µg, magnesium 18-22 mg, iron 1-2 mg, zinc 1-2.2 mg, manganese 370-330 µg, calcium 55-95 mg, phosphorus 40-60 mg, iodine 8-10µg, chlorine 100-140 mg, selenium 5-10 µg.

[0018] Further preferably, the sweetener consists of stevia and erythritol in a mass ratio of 3:2.

[0019] Further preferably, the fat consists of olive oil, corn oil and fish oil in a mass ratio of 2:3:1.

[0020] Further preferably, the carbohydrates consist of fructooligosaccharides and maltodextrin.

[0021] Further preferably, the dietary fiber consists of carrageenan, microcrystalline cellulose and xanthan gum in a mass ratio of 3:3:2.

[0022] The second aspect of the present invention provides a preparation process of the above-mentioned complete nutritional emulsion suitable for tumor patients, comprising the following steps: (1) Add 650-700 g of pure water per liter of volume into a preparation tank, dissolve or disperse solid raw materials such as protein powder, carbohydrates, minerals, dietary fiber, and water-soluble vitamins in the pure water through a mixer under strong stirring to obtain an aqueous phase; mix fats and oil-soluble vitamins to obtain an oil phase; mix the oil phase mixture with the aqueous phase in the preparation tank to obtain colostrum.

[0023] (2) Add the remaining pure water into the preparation tank according to the feed formula and stir to remove the foam to obtain a mixed liquid; the prepared mixed liquid is homogenized and emulsified by high pressure to form a final emulsion and then stored in a receiving tank.

[0024] (3) Place the product in a fully automatic UHT tubular ultra-high temperature instant sterilization at a temperature of 135-150°C and a heating time of 2-8 seconds to instantly kill bacteria and ensure the stability of heat-sensitive nutrients. The loss rate of heat-sensitive nutrients such as vitamins is less than 5%; at the same time, the product is commercially sterile.

[0025] The colostrum is prepared by a high-speed shear emulsifier head, the speed is between 600-10000 rpm, and the emulsification time is 2-5 min; preferably, the speed is between 600-10000 rpm, and the particle size D of the colostrum at this speed is 50 =1-10μm.

[0026] The final emulsion is made of a high-pressure homogenizer with a maximum working pressure of 600 bar, and a synchronous electric-controlled water cooling system with a chiller as the refrigerant, to ensure that the temperature of the product is always uniformly below 8°C during the emulsification process, and the active nutrients are not destroyed. Preferably, the pressure of high-pressure homogenization is 100-200 bar. Under this pressure condition, the final emulsion droplet D 50 <0.5μm.

[0027] The enteral complete nutrition emulsion suitable for tumor patients of the present invention has a uniform milky white appearance, good fluidity, no creaming phenomenon, final milk droplets smaller than 0.5 μm, and an apparent viscosity of the emulsion smaller than 150 mPa•s. After being placed at 25°C for 18 months, there are no obvious abnormal changes in appearance and various physical and chemical indicators.

[0028] The present invention is suitable for tumor patients over 10 years old and can be used as a single or partial nutrition source for direct oral or tube feeding nutrition supplementation.

[0029] Compared with the prior art, the present invention has the following advantages and beneficial effects:

[0030] 1. The present invention provides a formula and preparation process of an enteral complete nutritional emulsion suitable for tumor patients, uses a natural low-calorie sweetener as a flavoring agent, improves the flavor of the emulsifier while also expanding the use concerns of people with complications such as diabetes; in addition, the addition of stevioside not only helps to improve the stability of the complete nutritional emulsion, but also regulates the intestinal flora, increases the abundance of intestinal flora, especially the abundance of the beneficial flora bifidobacterium, reduces the amount of bifidobacterium added in the formula, and increases the recovery of patients.

[0031] 2. The present invention specifically adds probiotics (Lactobacillus acidophilus and Bifidobacterium) and ω-3 fatty acids. Bifidobacterium / Lactobacillus acidophilus can directly supplement the normal physiological bacteria in the human intestine and adjust the balance of intestinal flora; at the same time, it can improve the digestion and absorption of nutrients such as protein and calcium, and promote the production of multiple vitamins in the body for digestion and absorption by the body. The synergy of Lactobacillus acidophilus, Bifidobacterium and ω-3 fatty acids can regulate the immunotherapy effect of tumors by stimulating immune responses, reduce the side effects of certain anticancer drugs, and improve the quality of life of patients.

[0032] 3. The present invention adopts a reasonable formula compound and adopts secondary low-temperature emulsification technology and ultra-high temperature instant sterilization, so the preparation process is simple and stable. The prepared complete nutritional emulsion has low nutrient loss and remains stable at room temperature for 18 months, which far exceeds the 12-month shelf life of existing products on the market. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 A physical picture of the complete nutritional emulsion prepared in Example 1; Figure 2 The particle size change curve of the complete nutritional emulsion prepared in Example 1 within 18 months; Figure 3 This is the potential change curve of the complete nutritional emulsion prepared in Example 1 within 18 months. DETAILED DESCRIPTION

[0034] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0035] The test method described in the present invention is as follows: Particle size test method: measured using Malvern Mastersizer 3000 laser particle size analyzer. Parameter settings: dispersed phase (oil phase) refractive index 1.5, absorptivity 0.001; continuous phase refractive index 1.333; test temperature 25°C.

[0036] Potential test method: After the emulsion is appropriately diluted, the Zeta potential (mV) of the emulsion droplets is measured using a Brookhaven Zeta potential and nanoparticle size analyzer. Potential parameter settings: particle refractive index 1.467; particle absorption 0.002; dispersant refractive index 1.330; test temperature 25°C.

[0037] Apparent viscosity test method: using HAAKE RS600 rheometer, using shear scanning mode (shear rate 0.01-100s -1 ) Record the changes in the apparent viscosity of the sample. The test uses a 60mm diameter plate with a gap of 0.052mm and a test temperature of 25℃.

[0038] It should be noted that the raw materials or components not specifically described in the present invention are all commercially available food-grade or pharmaceutical-grade raw materials and additives. Example 1

[0039] The nutritional ingredients of complete nutrition emulsions, including protein, fat, carbohydrates, dietary fiber, complex vitamins (including vitamins A, D3, E, K1, B group), minerals (including calcium, phosphorus, magnesium, iron, zinc, selenium, etc.), sweeteners, and other nutrients (including ω-3 fatty acids, probiotics), are shown in the table below.

[0040] Table 1 Nutritional composition of complete nutrition special medical food emulsion .

[0041] The specific formula is shown in Table 2: Table 2 Formulation of Example 1 ( / 100 mL) .

[0042] The complete nutritional emulsion was prepared according to the nutritional ingredients in Table 1. The specific formulas of protein, fat, carbohydrates, dietary fiber and sweeteners are shown in Table 2.

[0043] Specifically, the preparation process of the complete nutritional emulsion suitable for tumor patients comprises the following steps: (1) Add 700 g of pure water per liter of the preparation tank, dissolve or disperse solid raw materials such as protein powder, carbohydrates, minerals, dietary fiber, sweeteners, probiotics and water-soluble vitamins in the pure water according to the formula amount through a mixer under strong stirring to obtain an aqueous phase, and adjust the pH to about 7.4; mix fat and oil-soluble vitamins to obtain an oil phase; mix the oil phase mixture with the water phase in the preparation tank, stir at a speed of 5000 rpm for 2 minutes to obtain colostrum; (2) Add the remaining pure water to the preparation tank according to the feeding formula and stir to remove the foam; the prepared mixed liquid is made into final emulsion by high-pressure homogenizer and then stored in the receiving tank; the working pressure of high-pressure homogenizer is 200 bar and the homogenization time is 2 minutes. A synchronous electric-controlled water cooling system with a chiller as the refrigerant is used to ensure that the temperature of the product is always uniformly below 8°C during the emulsification process, and the active nutrients are not destroyed; (3) Place the product in a fully automatic UHT tubular ultra-high temperature instant sterilizer; the temperature is 140°C and the heating time is 4 seconds.

[0044] The emulsion obtained in this example is milky white, has a uniform and stable appearance, good fluidity, and the loss of effective ingredients is less than 5%. The apparent viscosity of the emulsion is 127mPa•s. The stability of the complete nutritional special medical food emulsion was investigated at 3, 6, 9, 12, and 18 months. It shows that after being placed at 25°C for 18 months, there is no obvious abnormal change in appearance and various physical and chemical indicators ( Figure 2 , Figure 3 ). Example 2

[0045] Investigating the effects of sweeteners on the taste and stability of complete nutritional emulsions According to the nutritional ingredients in Table 1, a complete nutritional emulsion was prepared. The specific raw materials such as protein, fat, carbohydrate, dietary fiber, and probiotics were the same as those in Table 2. The difference was that the sweetener formula was different, wherein the emulsion with 0.3 g / 100 mL stevioside as the sweetener was recorded as sample T1, the emulsion with 0.4 g / 100 mL erythritol as the sweetener was recorded as T2, and the emulsion with 0.1 g / 100 mL stevioside + 0.2 g / 100 mL erythritol as the sweetener was recorded as T3. The emulsion was prepared according to the preparation process of the complete nutritional emulsion in Reference Example 1.

[0046] Table 3 Effects of sweeteners on the taste and stability of complete nutritional emulsions . Example 3

[0047] Investigating the effect of dietary fiber on the taste and stability of complete nutritional emulsions A complete nutritional emulsion was prepared according to the nutritional ingredients in Table 1. The specific formulas of protein, fat, carbohydrates and sweeteners were the same as those in Table 2, except that dietary fiber was added differently. The emulsion was prepared according to the preparation process of the complete nutritional emulsion in Example 1, wherein the emulsion containing dietary fiber ( / 100 mL) of 1 g carrageenan + 1 g microcrystalline cellulose + 1 g xanthan gum was recorded as S1; the emulsion containing 8 g carrageenan was recorded as S2, and the emulsion containing 8 g microcrystalline cellulose was recorded as S3.

[0048] Table 4 Effect of dietary fiber on the taste and stability of complete nutritional emulsions . Example 4

[0049] According to the nutritional components in Table 1 and the formula in Table 2, the colostrum preparation process was investigated, as shown in Table 5.

[0050] Table 5 Effects of colostrum processing on properties . Example 5

[0051] According to the nutritional components in Table 1 and the formula in Table 2, the effect of high-pressure homogenization emulsification process on the stability of complete nutritional emulsion was investigated. Under the process of colostrum speed of 5000 rpm and colostrum time of 2 min, the effect of final milk process on the properties of complete nutritional emulsion is shown in Table 6.

[0052] Table 6 Effect of high pressure homogenization emulsification process on properties . Comparative Example 1

[0053] According to the nutritional ingredients in Table 1 and the formula in Table 2, the traditional emulsification process was used, that is, water-soluble substances such as protein, carbohydrates, water-soluble vitamins, and minerals were added to water in sequence and mixed evenly; oil-soluble vitamins were dispersed in fat and mixed evenly; then the two solutions were mixed, high-speed emulsification was performed, and high-temperature sterilization (121°C, 20min) was performed to obtain a complete nutritional emulsion. The obtained emulsion was milky white and had good fluidity, but the added probiotics were basically inactivated after high-temperature sterilization, and the emulsion became unstable and flocculated after being placed for 6 months.

[0054] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A complete nutritional emulsion suitable for tumor patients, characterized in that: Each 100 mL of emulsion contains the following nutrients: protein 5-7 g, fat 5-7 g, carbohydrates 8-12 g, dietary fiber 0.5-10 g, sweetener 0.1-2 g, ω-3 fatty acids 250-2000 mg, probiotic composition 10-1000×10 9 CFU, as well as vitamins and minerals; among them, complex vitamins include: vitamin A 10-225 µg RE, vitamin D3 0.2-3.5µg, vitamin E 0.2-2 mg α-TE, vitamin K1 2-5 µg, vitamin B1 0.02-1mg, vitamin B2 0.02-1 mg, vitamin B6 0.02-1 mg, vitamin B12 0.05-1 µg, niacinamide 0.05-1mg, pantothenic acid 0.1-5 mg, biotin 0.5-5 µg, folic acid 10-50 µg, vitamin C 3-20mg, taurine 5-20 mg, L-carnitine 0.5-20 mg; minerals include: sodium 20-200 mg, potassium 30-300 mg, copper 20-200 µg, magnesium 5-150 mg, iron 0.2-3 mg, zinc 0.1-2.2 mg, manganese 6-600 µg, calcium 20-150mg, phosphorus 20-100 mg, iodine 2-50 µg, chlorine 1-200 mg, selenium 1-20 µg; The protein is one or more of whey protein, soy protein, and fish protein; the fat is one or more of soybean oil, peanut oil, linseed oil, olive oil, coconut oil, rapeseed oil, corn oil, camellia oil, walnut oil, fish oil, and milk fat rich in ω-3 fatty acids; the carbohydrate is one or more of glucose, oligofructose, and polysaccharide; the dietary fiber is one or more of pectin, xanthan gum, carrageenan, and microcrystalline cellulose; the sweetener includes at least stevioside; the probiotic composition consists of Lactobacillus acidophilus and Bifidobacterium, wherein Lactobacillus acidophilus accounts for 40-70% of the total mass of the probiotic composition.

2. The complete nutritional emulsion suitable for tumor patients according to claim 1, characterized in that: Each 100 mL of emulsion contains the following nutrients: protein 5-7 g, fat 5-7 g, carbohydrates 8-12 g, dietary fiber 8-10 g, sweetener 0.5 g, ω-3 fatty acids 1000 mg, probiotic composition 500 × 10 9 CFU, vitamin A 50 µg RE, vitamin D3 1-2 µg, vitamin E 1-2 mg α-TE, vitamin K1 3-5 µg, vitamin B1 0.2 mg, vitamin B2 0.2 mg, vitamin B6 0.25mg, vitamin B12 0.25 µg, niacinamide 0.8-1mg, pantothenic acid 0.6-1 mg, biotin 4-5 µg, folic acid 35-40 µg, vitamin C 15 mg, taurine 10 mg, L-carnitine 10 mg, sodium 90-120 mg, potassium 160-200 mg, copper 70-90 µg, magnesium 18-22 mg, iron 1-2 mg, zinc 1-2.2 mg, manganese 370-330 µg, calcium 55-95 mg, phosphorus 40-60mg, iodine 8-10 µg, chlorine 100-140 mg, selenium 5-10 µg.

3. The complete nutritional emulsion suitable for tumor patients according to claim 1, characterized in that: The sweetener consists of stevioside and erythritol in a mass ratio of 3:

2.

4. The complete nutritional emulsion suitable for tumor patients according to claim 1, characterized in that: The fat consists of olive oil, corn oil and fish oil in a mass ratio of 2:3:

1.

5. The complete nutritional emulsion suitable for tumor patients according to claim 1, characterized in that: The carbohydrates consist of oligofructose and maltodextrin.

6. The complete nutritional emulsion suitable for tumor patients according to claim 1, characterized in that: The dietary fiber consists of carrageenan, microcrystalline cellulose and xanthan gum in a mass ratio of 3:3:

2.

7. The method for preparing the complete nutritional emulsion suitable for tumor patients according to any one of claims 1 to 6, characterized in that: The steps include: (1) Add pure water to a preparation tank, dissolve or disperse protein, carbohydrates, minerals, dietary fiber, sweeteners, and water-soluble vitamins in the pure water through a mixer under strong stirring to obtain a water phase; mix fat and oil-soluble vitamins to obtain an oil phase; mix the oil phase mixture with the water phase in the preparation tank to obtain colostrum; (2) Add the remaining pure water into the preparation tank according to the feed formula and stir to remove the foam to obtain a mixed liquid; the prepared mixed liquid is homogenized and emulsified by high pressure to obtain a final emulsion, which is then stored in a receiving tank; (3) Place the product in a fully automatic UHT tubular ultra-high temperature instant sterilization at a temperature of 135-150°C and a heating time of 2-8 seconds.

8. The method for preparing the complete nutritional emulsion suitable for tumor patients according to claim 7, characterized in that: In step (1), the colostrum is prepared by using a high-speed shear emulsifier head with a rotation speed between 600-10000 rpm and an emulsification time of 2-5 minutes.

9. The method for preparing the complete nutritional emulsion suitable for tumor patients according to claim 7, characterized in that: The high-pressure homogenization emulsification is carried out at a low temperature, wherein the low temperature is a temperature that is uniformly below 8° C. The pressure of the high-pressure homogenization emulsification is 100-200 bar.

10. The method for preparing the complete nutritional emulsion suitable for tumor patients according to claim 7, characterized in that: The particle size of the prepared complete nutritional emulsion is less than 0.5 μm, the absolute potential is 30-40 mV, and the emulsion remains stable after being placed at 25° C. for 18 months.

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