A kind of shuttle-shaped structure polymer nanoparticle and preparation method thereof

Abstract

The invention belongs to the technical field of non-spherical polymer materials, and specifically relates to a shuttle-shaped polymer nanoparticle and a preparation method thereof. The preparation method of the shuttle-shaped polymer nanoparticle comprises the following steps: by a step-by-step polymerization method, a stabilizer, an initiator, a comonomer styrene and 4-vinyl pyridine are uniformly dispersed in ethanol, and the volume ratio of the styrene and 4-vinyl pyridine is (18-22): (18-22); the solution A is reacted under an inert gas atmosphere to obtain a micellar solution B; divinylbenzene is added to styrene to obtain a solution C; the solution C is injected into the micellar solution B for reaction, centrifuged, and washed to obtain a shuttle-shaped structure, uniform size, and polymer nanoparticles with pyridine functional groups on the surface. The present invention can avoid the defects of complicated steps, low preparation efficiency, and the need for special synthesis equipment in the traditional shuttle-shaped polymer particle synthesis process, and is suitable for large-scale production.

Description

Technical Field

[0001] The invention belongs to the technical field of non-spherical polymer materials, and in particular relates to a shuttle-shaped structure polymer nanoparticle and a preparation method thereof. Background Art

[0002] Due to their special geometric structure, spindle-shaped particles often show optical and fluid dynamic properties that are significantly different from those of ordinary spherical particles, and have broad application prospects in the fields of optical materials, fluid performance regulation materials, biomedical materials, and drug delivery. However, due to the requirements of thermodynamic stability and symmetry, polymer particles prepared by conventional polymerization methods such as emulsion polymerization, suspension polymerization, and dispersion polymerization are usually spherical particles, while the preparation of spindle-shaped particles is more difficult. Although some spindle-shaped polymer particle preparation technologies have been developed, such as microfluidics, spherical particle stretching, and template methods, etc.

[0003] Although the microfluidic method can prepare particles with good monodispersity in the shape of discs, ellipses and rods, the preparation process requires special equipment and has low efficiency. In the spherical particle stretching method, the particle size is mainly controlled by the original particles. Although the operation is simple and the stretching ratio is adjustable, the energy consumption is large. The template method can accurately control the shape and size of the prepared particles, but the preparation process requires special template materials. Most of the preparation methods of these shuttle-shaped particles have limitations, such as complex and cumbersome synthesis steps, special raw materials and equipment, and low preparation efficiency, which restricts the large-scale production and application of shuttle-shaped polymer particles. Therefore, it is of great significance to develop a method for preparing shuttle-shaped particles with simple steps, high efficiency and low production cost. Summary of the invention

[0004] In order to overcome the disadvantage that conventional polymerization methods are difficult to synthesize shuttle-shaped polymer particles, the present invention provides a shuttle-shaped polymer nanoparticle and a preparation method thereof. Compared with methods such as spherical particle stretching method, the step-by-step polymerization method provided by the present invention can avoid the defects of complicated synthesis steps, special synthesis equipment, low preparation efficiency, etc., and efficiently synthesize shuttle-shaped polymer particles, and the prepared polymer conductive microspheres have uniform size.

[0005] In order to achieve the above object, the specific technical solution adopted by the present invention is as follows:

[0006] The present invention provides a method for preparing shuttle-shaped polymer nanoparticles, comprising the following steps:

[0007] (1) uniformly dispersing a stabilizer, an initiator, and a comonomer in ethanol to obtain a solution A; the comonomer is a mixture of styrene and 4-vinylpyridine; the volume ratio of styrene to 4-vinylpyridine is (18-22):(18-22);

[0008] (2) reacting the solution A under an inert gas atmosphere to obtain a micellar solution B;

[0009] (3) adding divinylbenzene to styrene to obtain solution C;

[0010] (4) Injecting the solution C into the micelle solution B for reaction, centrifuging, and washing.

[0011] Preferably, the stabilizer in step (1) is at least one selected from polyvinyl pyrrolidone, polyethylene glycol and sodium hexadecylbenzene sulfonate.

[0012] Preferably, the initiator in step (1) is at least one selected from azobisisobutyronitrile (AIBN), dimethyl azobisisobutyrate, dibenzoyl peroxide and ammonium persulfate.

[0013] Preferably, in step (1), the ratio of the amount of stabilizer, initiator, comonomer and ethanol is (0.1-0.5 g): (20-80 mg): (30-50 ml): (10-40 ml).

[0014] Preferably, in step (2), the reaction conditions are: 60-80° C. for 6-10 h.

[0015] Preferably, in step (2), the inert gas is nitrogen.

[0016] Preferably, in step (3), the usage ratio of divinylbenzene to styrene is (0.02-0.10 mL): (1-3 mL).

[0017] Preferably, in step (4), the reaction conditions are: reaction at 60-80° C. for 4-8 h under an inert gas atmosphere. Preferably, the inert gas is nitrogen.

[0018] The present invention also provides a shuttle-shaped polymer nanoparticle, which is prepared by the above-mentioned preparation method.

[0019] The present invention has the following beneficial effects:

[0020] 1. The present invention can achieve a precise transformation from spherical particles to spindle-shaped particles by changing the ratio of different specific monomers, thereby realizing the synthesis of large-sized spindle-shaped polymer particles.

[0021] 2. The step-by-step polymerization method designed in the present invention can synthesize a large number of shuttle-shaped polymer particles in one pot, and the synthesis equipment is simple. Compared with the existing spherical particle stretching method, the step-by-step polymerization method not only has lower energy consumption, but also has higher synthesis efficiency, and is suitable for large-scale production.

[0022] 3. The step-by-step polymer method designed in the present invention not only has high synthesis efficiency, but also prepares shuttle-shaped polymer particles with uniform size, which is beneficial to improving the optical properties of shuttle-shaped polymer materials.

[0023] 4. The pyridine functional groups are evenly distributed on the surface of the shuttle-shaped polymer particles prepared according to the present invention, which is convenient for subsequent functionalization and surface modification of the shuttle-shaped polymer particles.

[0024] 5. The surface of the shuttle-shaped polymer particles prepared by the present invention has a cross-linked structure, which can improve the structural stability of the shuttle-shaped polymer particles. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 This is a SEM photograph of the shuttle-structured polymer nanoparticles synthesized in Example 1.

[0026] Figure 2 This is a SEM photograph of the shuttle-shaped polymer nanoparticles in Example 1 under a larger range.

[0027] Figure 3 This is a SEM photograph of the shuttle-structured polymer nanoparticles synthesized in Example 4.

[0028] Figure 4 This is a SEM photograph of the shuttle-structured polymer nanoparticles synthesized in Example 5.

[0029] Figure 5 This is a SEM photograph of the mixture of spherical, spindle-shaped and irregular particles synthesized in Comparative Example 1.

[0030] Figure 6 This is a SEM photograph of the mixture of spherical and irregular particles synthesized in Comparative Example 2.

[0031] Figure 7 This is the SEM photograph of the polymer microspheres synthesized in Comparative Example 3.

[0032] Figure 8 This is a SEM photograph of the irregular particles synthesized in Comparative Example 8.

[0033] Fig. 9 This is the SEM photograph of the polymer microspheres synthesized in Comparative Example 11.

[0034] Fig.10 This is a SEM photograph of the polymer microspheres with uniform size synthesized in Comparative Example 12. DETAILED DESCRIPTION

[0035] The present invention provides a suitable preparation method, which is to first polymerize and prepare a soluble polymer with a longer chain by a step-by-step polymerization method, and use the polymer chain itself as a macromolecular stabilizer. In the further cross-linking polymerization process, due to the stabilizing effect of the macromolecular chain on the surface of the polymer particles, the deformed polymer particles formed by shearing can maintain the stability of shape and size during the polymerization process, thereby obtaining shuttle-shaped polymer particles. However, in the process of preparing long-chain soluble polymers, the proportion of comonomers is extremely critical. Because when the proportion of solubilizing polymer chain fragments generated by the polymerization of functional monomers is low, the solubility of the polymer chain in the system is reduced, and the chain length of the polymer is shortened. In the further cross-linking polymerization process, its stabilizing effect will be weakened, and it is difficult to achieve the synthesis of shuttle-shaped polymer particles.

[0036] Specifically, a method for preparing shuttle-shaped polymer nanoparticles comprises the following steps:

[0037] (1) by a stepwise polymerization method, 0.1-0.5 g of a stabilizer, 20-80 mg of an initiator, and 30-50 ml of a comonomer are uniformly dispersed in 10-40 ml of ethanol to obtain a solution A;

[0038] The stabilizer is selected from at least one of polyvinyl pyrrolidone (average molecular weight 20000-360000), polyethylene glycol (average molecular weight 2000-80000) and sodium hexadecylbenzene sulfonate. The main function of the stabilizer is to prevent the polymer particles from condensing or agglomerating during the reaction. They form a protective layer by adsorbing on the surface of the particles to ensure that the particles remain uniformly dispersed during the polymerization reaction. At the same time, the stabilizer also helps to control the morphology of the particles, especially when synthesizing spindle-shaped particles, they can provide the particles with morphology retention and dimensional stability.

[0039] The initiator is selected from at least one of azobisisobutyronitrile, dimethyl azobisisobutyrate, dibenzoyl peroxide and ammonium persulfate. The initiator is used to initiate the polymerization reaction of the comonomer, and by providing free radicals, initiates the free radical copolymerization reaction of styrene and 4-vinylpyridine to form a long-chain polymer.

[0040] The comonomers are styrene and 4-vinylpyridine; preferably, the volume ratio of styrene to 4-vinylpyridine is (18-22): (18-22). The two comonomers react together to form a polymer skeleton. Styrene is used as a comonomer, and styrene provides the main structure of the polymer skeleton, forming a stable carbon chain basis. The presence of styrene can help generate long-chain polymers with good mechanical properties, providing strength and morphological stability for subsequent deformed particles. 4-vinylpyridine introduces pyridine groups during the copolymerization process. The pyridine groups have strong reactivity and functionalization potential, and can provide the possibility of subsequent chemical modification on the surface of polymer particles. In addition, the presence of 4-vinylpyridine also contributes to the structural stability of the particles. By adjusting their ratio, the morphology of the particles can be controlled to achieve a transition from spherical to spindle-shaped particles. The ratio of styrene to 4-vinylpyridine is a key factor in determining the morphology of polymer particles.

[0041] (2) reacting the solution A at 60-80° C. for 6-10 hours under an inert gas atmosphere to obtain a micellar solution B;

[0042] Preferably, the inert gas is nitrogen;

[0043] (3) Add 0.02-0.10 mL of divinylbenzene to 1-3 mL of styrene to obtain solution C. Divinylbenzene is used as a cross-linking monomer, and its two vinyl groups can undergo a cross-linking reaction with the polymer chain to form a cross-linked structure. This cross-linking not only enhances the mechanical strength of the particles, but also improves the morphological stability of the particles, allowing the shuttle structure to remain intact under external stress or environmental changes. In addition, the cross-linked structure can also reduce the risk of morphological collapse of the particles during long-term storage or use, thereby ensuring the service life and functional stability of the particles. Styrene acts as a diluent and comonomer. Styrene not only participates in the copolymerization reaction, but also makes the cross-linking reaction more uniform by adjusting the viscosity and reaction rate of the solution.

[0044] (4) Injecting the solution C into the micellar solution B, reacting at 60-80° C. for 4-8 hours under an inert gas atmosphere, centrifuging and washing to obtain the shuttle-shaped polymer nanoparticles. The purpose of this stage is to form a cross-linked structure on the surface of the shuttle-shaped polymer particles through a cross-linking reaction, further enhancing the stability and mechanical strength of the particles. After the reaction is completed, the unreacted substances and by-products are removed by centrifugation and washing to finally obtain the target shuttle-shaped polymer nanoparticles.

[0045] The invention provides a method for preparing shuttle-shaped polymer nanoparticles. The particle skeleton is generated by precisely controlling the ratio of comonomers styrene and 4-vinylpyridine by a step-by-step polymerization method. Styrene provides a stable carbon chain structure, and 4-vinylpyridine introduces a modifiable pyridine group. The ratio can be regulated to achieve the transformation from spherical to shuttle-shaped particles. An initiator is used to initiate free radical polymerization, and a stabilizer prevents agglomeration by adsorbing on the surface of particles, thereby maintaining uniform dispersion and morphological stability of the particles. The reaction is carried out under an inert atmosphere, and then divinylbenzene is added as a cross-linking monomer to further enhance the mechanical strength and structural stability of the particles, thereby ensuring that the shuttle-shaped structure maintains integrity under environmental changes. Unreacted products are removed by centrifugation and washing, and finally high-quality shuttle-shaped polymer nanoparticles are obtained, which are suitable for large-scale production and a variety of functional applications.

[0046] The technical solution of the present invention is further described below in conjunction with specific embodiments, but the protection scope of the present invention is not limited to these embodiments. Any changes or equivalent substitutions that do not deviate from the concept of the present invention are included in the protection scope of the present invention.

[0047] Polyvinylpyrrolidone (PVP), Polyvinylpyrrolidone, average molecular weight 24000, K23-27, provided by Aladdin brand, CAS number: 9003-39-8.

[0048] Example 1

[0049] (1) 0.3 g of polyvinyl pyrrolidone and 50 mg of AIBN were added to 25 mL of ethanol, and then 2 mL of styrene monomer and 2 mL of 4-vinyl pyridine monomer were added and mixed uniformly to obtain solution A;

[0050] (2) Solution A was transferred to a round-bottom flask and stirred for 30 min to make the solution uniform; the temperature was raised to 70 °C under a nitrogen atmosphere and reacted for 8 h to obtain a homogeneous micellar solution B;

[0051] (3) adding 0.06 mL of divinylbenzene monomer to 2 mL of styrene monomer and mixing well to obtain solution C;

[0052] (4) Solution C was injected into the round-bottom flask containing the micelle solution B, and the reaction was continued at 70° C. for 6 h under a nitrogen environment to obtain a light yellow suspension solution. The product was then collected by centrifugation and washed with ethanol to prepare large-sized spindle-shaped polymer nanoparticles with a particle length of about 40 μm and a diameter of about 15 μm. Figure 1 shown. Figure 2 This is a SEM photograph of the shuttle-shaped polymer nanoparticles in Example 1 under a larger range.

[0053] Example 2

[0054] (1) 0.4 g of polyvinyl pyrrolidone and 80 mg of AIBN were added to 25 mL of ethanol, and then 2 mL of styrene monomer and 2 mL of 4-vinyl pyridine monomer were added and mixed uniformly to obtain solution A;

[0055] (2) Solution A was transferred to a round-bottom flask and stirred for 30 min to make the solution uniform; the temperature was raised to 70 °C under a nitrogen atmosphere and reacted for 8 h to obtain a homogeneous micellar solution B;

[0056] (3) adding 0.06 mL of divinylbenzene monomer to 2 mL of styrene monomer and mixing well to obtain solution C;

[0057] (4) Solution C was injected into the round-bottom flask containing the micelle solution B, and the reaction was continued at 70° C. for 6 h under a nitrogen environment. The product was collected by centrifugation and washed with ethanol to obtain spindle-shaped polymer nanoparticles.

[0058] Example 3

[0059] (1) 0.2 g of polyvinyl pyrrolidone and 30 mg of AIBN were added to 25 mL of ethanol, and then 2 mL of styrene monomer and 2 mL of 4-vinyl pyridine monomer were added and mixed uniformly to obtain solution A;

[0060] (2) Solution A was transferred to a round-bottom flask and stirred for 30 min to make the solution uniform; the temperature was raised to 70 °C under a nitrogen atmosphere and reacted for 8 h to obtain a homogeneous micellar solution B;

[0061] (3) adding 0.06 mL of divinylbenzene monomer to 2 mL of styrene monomer and mixing well to obtain solution C;

[0062] (4) Solution C was injected into the round-bottom flask containing the micelle solution B, and the reaction was continued at 70° C. for 6 h under a nitrogen environment. The product was collected by centrifugation and washed with ethanol and a mixed solution of ethanol and water to obtain spindle-shaped polymer nanoparticles.

[0063] Example 4

[0064] Example 4 The only difference from Example 1 is step (1).

[0065] Specifically, 0.3 g of polyvinyl pyrrolidone and 50 mg of AIBN were added to 25 mL of ethanol, and then 2.2 mL of styrene monomer and 1.8 mL of 4-vinyl pyridine monomer were added and mixed evenly to obtain solution A.

[0066] The final result is to obtain spindle-shaped polymer nanoparticles with a particle length of about 36 μm and a diameter of about 15 μm. Figure 3 shown.

[0067] Example 5

[0068] Example 5 The only difference from Example 1 is step (1).

[0069] Specifically, 0.3 g of polyvinyl pyrrolidone and 50 mg of AIBN were added to 25 mL of ethanol, and then 1.8 mL of styrene monomer and 2.2 mL of 4-vinyl pyridine monomer were added and mixed uniformly to obtain solution A.

[0070] The final result is to obtain spindle-shaped polymer nanoparticles with a particle length of about 38 μm and a diameter of about 14 μm. Figure 4 shown.

[0071] Comparative Example 1

[0072] The only difference between Comparative Example 1 and Example 1 is that step (1) is different.

[0073] Specifically, 0.3 g of polyvinyl pyrrolidone and 50 mg of AIBN were added to 25 mL of ethanol, and then 2.3 mL of styrene monomer and 1.7 mL of 4-vinyl pyridine monomer were added and mixed uniformly to obtain solution A.

[0074] The final result is a mixture of spherical, spindle-shaped and irregularly shaped nanoparticles, such as Figure 5 As shown, uniform spindle-shaped nanoparticles cannot be prepared.

[0075] Comparative Example 2

[0076] The only difference between Comparative Example 2 and Example 1 is that step (1) is different.

[0077] Specifically, 0.3 g of polyvinyl pyrrolidone and 50 mg of AIBN were added to 25 mL of ethanol, and then 2.7 mL of styrene monomer and 1.3 mL of 4-vinyl pyridine monomer were added and mixed evenly to obtain solution A.

[0078] The final result is a mixture of spherical and irregularly shaped nanoparticles, such as Figure 6 As shown, the corresponding spindle-shaped nanoparticles cannot be prepared.

[0079] Comparative Example 3

[0080] The only difference between Comparative Example 3 and Example 1 is that step (1) is different.

[0081] Specifically, 0.3 g of polyvinyl pyrrolidone and 50 mg of AIBN were added to 25 mL of ethanol, and then 3.2 mL of styrene monomer and 0.8 mL of 4-vinyl pyridine monomer were added and mixed evenly to obtain solution A.

[0082] The final result is that only microspheres of uneven size are obtained, such as Figure 7 As shown, the corresponding spindle-shaped nanoparticles cannot be prepared.

[0083] Comparative Example 4

[0084] The only difference between Comparative Example 4 and Example 1 is that step (1) is different.

[0085] Specifically, 0.3 g of polyvinyl pyrrolidone and 50 mg of AIBN were added to 25 mL of ethanol, and then 1.7 mL of styrene monomer and 2.3 mL of 4-vinyl pyridine monomer were added and mixed evenly to obtain solution A.

[0086] The final result is that only a transparent solution is obtained, and the corresponding spindle-shaped nanoparticles cannot be prepared.

[0087] Comparative Example 5

[0088] The only difference between Comparative Example 5 and Example 1 is that step (1) is different.

[0089] Specifically, 0.3 g of polyvinyl pyrrolidone and 50 mg of AIBN were added to 25 mL of ethanol, and then 1.3 mL of styrene monomer and 2.7 mL of 4-vinyl pyridine monomer were added and mixed evenly to obtain solution A.

[0090] The final result is that only a transparent solution is obtained, and the corresponding spindle-shaped nanoparticles cannot be prepared.

[0091] Comparative Example 6

[0092] The only difference between Comparative Example 6 and Example 1 is that step (1) is different.

[0093] Specifically, 0.3 g of polyvinyl pyrrolidone and 50 mg of AIBN were added to 25 mL of ethanol, and then 0.8 mL of styrene monomer and 3.2 mL of 4-vinyl pyridine monomer were added and mixed evenly to obtain solution A.

[0094] The final result is that only a transparent solution is obtained, and the corresponding spindle-shaped nanoparticles cannot be prepared.

[0095] When the proportion of 4-vinylpyridine monomer is too low, the generated soluble polymer chain is short and cannot provide sufficient stability in the subsequent polymerization process, resulting in the inability to maintain the particle morphology and thus unable to form shuttle-shaped polymer particles. On the contrary, when the proportion of 4-vinylpyridine monomer is too high, the solubility of the polymer chain is too high, making the micelles in the system too stable, and ultimately forming a soluble micelle solution, and unable to generate shuttle-shaped polymer particles.

[0096] Comparative Example 7

[0097] The only difference between Comparative Example 7 and Example 1 is that step (3) is different.

[0098] Step (3) is to use 2.06 mL of styrene monomer as solution C.

[0099] Result: Only a transparent solution was obtained and spindle-shaped nanoparticles could not be prepared.

[0100] Due to the lack of divinylbenzene monomer with cross-linking function in the system during the second polymerization, the resulting polymer product has too high solubility and cannot form a stable morphological structure. Ultimately, only a soluble micelle solution is produced, and therefore, spindle-shaped polymer particles cannot be obtained.

[0101] Comparative Example 8

[0102] The only difference between Comparative Example 8 and Example 1 is that step (3) is different.

[0103] Step (3) is to use 2.06 mL of divinylbenzene monomer as solution C.

[0104] The final result is only a solid precipitate with irregular morphology, such as Figure 8 As shown, the corresponding spindle-shaped nanoparticles cannot be prepared.

[0105] During the second polymerization, due to the addition of excessive divinylbenzene monomer into the system, excessive cross-linking occurred between the polymer products, the solubility of the polymer products decreased rapidly, and irregular solid precipitates were produced. The morphology of the particles could not be controlled, and therefore, spindle-shaped polymer particles could not be prepared.

[0106] Comparative Example 9

[0107] The only difference between Comparative Example 1 and Example 1 is that step (1) is different.

[0108] Specifically, 0.3 g of polyvinyl pyrrolidone and 50 mg of AIBN were added to 25 mL of ethanol, and then 4 mL of styrene monomer was added and mixed evenly to obtain solution A.

[0109] The final result is that only polymer microspheres are obtained, and spindle-shaped nanoparticles cannot be prepared.

[0110] Comparative Example 10

[0111] The only difference between Comparative Example 1 and Example 1 is that step (1) is different.

[0112] Specifically, 0.3 g of polyvinyl pyrrolidone and 50 mg of AIBN were added to 25 mL of ethanol, and then 4 mL of 4-vinyl pyridine monomer was added and mixed evenly to obtain solution A.

[0113] The final result is that only a transparent solution is obtained, and spindle-shaped nanoparticles cannot be prepared.

[0114] Comparative Example 11

[0115] Compared with Example 1, the ratio of the comonomers in step (1) was modified in this comparative example. Specifically, 2 mL of styrene monomer and 2 mL of 4-vinylpyridine were added to ethanol instead of 2 mL of styrene monomer and 0.2 mL of 4-vinylpyridine. Step (3) was deleted. As a result, only microspheres with smooth surface but uneven size were obtained, such as Fig. 9 As shown, the corresponding spindle-shaped nanoparticles cannot be prepared.

[0116] Comparative Example 12

[0117] Compared with Example 1, the composition of the monomers in step (1) was modified in this comparative example. Specifically, 2 mL of styrene monomer and 2 mL of 4-vinylpyridine were added to ethanol, and only 2 mL of styrene monomer was added to ethanol. At the same time, step (3) was deleted. As a result, only microspheres with smooth surface and uniform size were obtained, such as Fig.10 As shown, the corresponding spindle-shaped nanoparticles cannot be prepared.

[0118] This specific implementation is only an explanation of the present invention, not a limitation of the present invention. Any changes made by those skilled in the art after reading the specification of the present invention will be protected by the patent law as long as they are within the scope of the claims of the present invention.

Claims

1. A method for preparing shuttle-shaped polymer nanoparticles, characterized in that: The steps include: (1) Evenly dispersing a stabilizer, an initiator, and a comonomer in ethanol to obtain a solution A; the comonomer is a mixture of styrene and 4-vinylpyridine; the volume ratio of styrene to 4-vinylpyridine is (18-22):(18-22); (2) reacting the solution A under an inert gas atmosphere to obtain a micellar solution B; (3) adding divinylbenzene to styrene to obtain solution C; (4) injecting the solution C into the micellar solution B for reaction, centrifuging and washing; In step (1), the stabilizer is polyvinyl pyrrolidone; In step (1), the initiator is selected from at least one of azobisisobutyronitrile, dimethyl azobisisobutyrate and dibenzoyl peroxide; In step (1), the ratio of the amount of stabilizer, initiator, comonomer and ethanol is (0.1-0.5 g): (20-80 mg): (30-50 ml): (10-40 ml); In step (2), the inert gas is nitrogen; In step (2), the reaction conditions are: 60-80°C for 6-10 h; In step (3), the ratio of divinylbenzene to styrene is (0.02-0.10 mL): (1-3 mL); In step (4), the reaction conditions are: 60-80° C. for 4-8 h under an inert gas atmosphere.

2. A shuttle-shaped polymer nanoparticle, characterized in that: The preparation method according to claim 1 is adopted.

Images