Creatine composition and application thereof

Abstract

The invention provides a creatine composition and application thereof. The composition comprises creatine, cyclodextrin, alanine and malic acid. The creatine is compounded with the cyclodextrin, the alanine and the malic acid, so that the original effect of the creatine can be improved, the mouth feel is better, and the effect is better.

Description

Technical Field

[0001] The present invention relates to the field of chemical technology, and in particular to a creatine composition and application thereof. Background Art

[0002] Creatine is a precursor of creatine phosphate, which is a muscle strength enhancer widely used in the field of sports nutrition. Creatine phosphate is a "backup source" of energy. When ATP levels drop, creatine phosphate can resynthesize ATP. Studies have shown that creatine supplementation can increase muscle creatine phosphate reserves, help improve the resynthesis of ATP and creatine phosphate during exercise, thereby improving exercise capacity, and has a strength-enhancing effect on short-term (less than 30s), intermittent, high-intensity, and resistance exercises.

[0003] Currently, common creatine products on the market mainly include pure creatine powder, creatine tablets, creatine capsules and other dosage forms; the sources of creatine include creatine monohydrate and esterified creatine, among which creatine monohydrate is the most effective and widely used. In terms of taste, almost all pure creatine products on the market are "bitter", with extremely poor flavor and poor absorption effect. Developing a creatine that is easy to take and meets the needs of the target population can fill the gap in the current market. Summary of the invention

[0004] The purpose of the present invention is to overcome the shortcomings of the prior art and provide a creatine composition and application thereof.

[0005] In a first aspect, the present invention provides a creatine composition comprising: creatine, cyclodextrin, alanine and malic acid.

[0006] β-cyclodextrin tastes slightly sweet. It can prevent the volatilization of various spices, oils, spices and other volatile substances during food processing and storage, and keep the food aroma unchanged for a long time. It can keep the nutrients such as pigments, amino acids and vitamins that are easy to oxidize, decompose when exposed to light, and deteriorate when exposed to heat stable. It can remove the fishy smell of fish and meat, the unpleasant taste of nutrients such as vitamin B added to food, and the peculiar smell in other foods, increase the palatability of food, and improve the taste of sweeteners such as saccharin and sodium cyclamate. For beverages with high oil content, such as ice cream, coffee drinks and other emulsified foods, it can form a long-term stable emulsion. If used in combination with food emulsifiers, the emulsification effect is better. It can slowly release food preservatives and anti-staling agents, improve the antiseptic effect, and extend the shelf life of food.

[0007] β-alanine tastes slightly sweet and is the second most research-supported sports nutrition in the world after creatine. β-alanine powder is more popular in the European and American markets. It is generally believed that β-alanine can work together with L-histidine to increase the content of carnosine in skeletal muscle. β-alanine powder is suitable for people who participate in sports that require explosive power, such as sprinting, weightlifting training or boxing. It has a significant effect on improving explosive power and is also an ideal choice for participants in long-term endurance sports. Helps blood sugar control and insulin resistance. β-alanine may improve body composition by increasing training volume and promoting muscle growth. Studies have shown that continuous supplementation of β-alanine for three weeks can increase lean muscle mass. Supplementation of β-alanine may reduce fasting blood sugar, HbA1c, fasting insulin, etc. β-alanine may help prevent prostate enlargement and relieve pain related to prostate problems, such as painful urination, swelling and pain, and symptoms caused by prostate cancer.

[0008] Malic acid is an important natural organic acid, widely distributed in plants, animals and microbial cells, and its taste is close to the sour taste of natural apples. Malic acid has a significant flavoring effect, and its sour taste is soft and refreshing. It can effectively improve its taste and flavor; health drinks can be developed by using malic acid's anti-fatigue, liver, kidney and heart protection effects. Adding L-malic acid to food can adjust the pH, and with its own antibacterial effect, L-malic acid is also widely used in other food industries, such as as a preservative for aquatic products.

[0009] The composition formed by creatine, cyclodextrin, alanine and malic acid can improve the original effect of creatine, have a better taste and better effect.

[0010] In some embodiments, the creatine comprises creatine monohydrate.

[0011] In some embodiments, the particle size of the creatine is 100-300 mesh, for example, 120 mesh, 150 mesh, 180 mesh, 200 mesh, 220 mesh, 240 mesh, 260 mesh, 280 mesh, 300 mesh or any value therebetween.

[0012] In some embodiments, the cyclodextrin comprises β-cyclodextrin.

[0013] In some embodiments, the alanine comprises β-alanine.

[0014] In some embodiments, the malic acid comprises L-malic acid.

[0015] In some embodiments, the mass ratio of creatine to alanine is 50-120:1, for example, 80:1, 85:1, 90:1, 92:1, 95:1, 97:1, 100:1, 105:1, 110:1, 115:1, 120:1 or any value therebetween.

[0016] In some embodiments, the mass ratio of creatine to alanine is 80-100:1.

[0017] In some embodiments, the mass ratio of cyclodextrin to alanine is 0.5-15:1, for example, 1:1, 2:1, 3:1, 4:1, 5:1, 6:1, 7:1, 8:1, 9:1, 10:1, 11:1, 12:1, 13:1, 14:1, 15:1 or any value therebetween.

[0018] In some embodiments, the mass ratio of cyclodextrin to alanine is 2-10:1.

[0019] In some embodiments, the mass ratio of cyclodextrin to alanine is 5-8:1.

[0020] In some embodiments, the mass ratio of alanine to malic acid is 1:0.1-10, for example, 1:0.5, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10 or any value therebetween.

[0021] In some embodiments, the mass ratio of alanine to malic acid is 1:0.5-5.

[0022] In some embodiments, the composition comprises, by weight: 50-150 parts of creatine, 1-15 parts of cyclodextrin, 0.1-10 parts of alanine and 0.5-10 parts of malic acid.

[0023] In some embodiments, the composition comprises 50 parts, 70 parts, 90 parts, 110 parts, 130 parts, 150 parts of creatine, or any value therebetween, by weight.

[0024] In some embodiments, the composition comprises 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts of cyclodextrin, or any value therebetween, by weight.

[0025] In some embodiments, the composition comprises 0.1 parts, 0.5 parts, 1 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts of alanine, or any value therebetween, by weight.

[0026] In some embodiments, the composition comprises 0.5 parts, 1 parts, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts of malic acid or any value therebetween, by weight.

[0027] In some embodiments, the composition comprises: 50-120 parts of creatine, 2-10 parts of cyclodextrin, 0.5-8 parts of alanine and 0.5-8 parts of malic acid.

[0028] In some embodiments, the composition comprises: 80-120 parts of creatine, 5-8 parts of cyclodextrin, 0.5-5 parts of alanine and 1-5 parts of malic acid.

[0029] In a second aspect, the present invention provides an embedded creatine, comprising the creatine composition according to the first aspect of the present invention.

[0030] The embedded creatine of the present invention overcomes the bitterness of creatine monohydrate, increases the solubility of creatine monohydrate in water, and enables creatine monohydrate to be uniformly dispersed in water. People can eat creatine monohydrate more easily and have a better taste. Moreover, beta-cyclodextrin, beta-alanine, and L-malic acid added in the preparation of the dispersion are all healthy foods, and can also play a sustained-release role after the embedding technology, thereby prolonging the action time of creatine monohydrate.

[0031] In a third aspect, the present invention provides a method for preparing the embedded creatine according to the second aspect of the present invention, comprising the following steps:

[0032] (1) compounding the creatine composition described in the first aspect of the present invention with water to obtain a creatine dispersion;

[0033] (2) homogenizing and drying the creatine dispersion to obtain the embedded creatine.

[0034] In some embodiments, the method for preparing the creatine dispersion comprises the following steps: mixing creatine with water, and then adding alanine, malic acid and cyclodextrin to mix, to obtain the creatine dispersion.

[0035] In some embodiments, after adding alanine, malic acid, and cyclodextrin and mixing, sonication may be performed.

[0036] In some embodiments, the ultrasonication time can be 0.5-2 hours, for example, 0.5 hours, 0.7 hours, 0.9 hours, 1.1 hours, 1.3 hours, 1.5 hours, 1.7 hours, 1.9 hours, 2 hours or any value therebetween.

[0037] In some embodiments, the mass ratio of creatine to water is 80-120:300, for example, 80:300, 85:300, 90:300, 95:300, 97:300, 100:300, 110:300, 120:300 or any value therebetween.

[0038] In some embodiments, the particle size of the microparticles in the homogenized creatine dispersion is 50-300 nm, for example, 70 nm, 90 nm, 110 nm, 150 nm, 190 nm, 230 nm, 270 nm or any value therebetween.

[0039] In some embodiments, the drying is spray drying.

[0040] In some embodiments, the feed flow rate of the spray drying is 50-200 mL / min; for example, 50 mL / min, 130 mL / min, 160 mL / min, 190 mL / min, 200 mL / min or any value therebetween.

[0041] In some embodiments, the inlet air temperature of the spray drying is 120-130°C, for example, 120°C, 122°C, 124°C, 126°C, 128°C, 130°C or any value therebetween.

[0042] In some embodiments, the outlet air temperature of the spray drying is 70-75°C, for example, 70°C, 71°C, 72°C, 73°C, 74°C, 75°C or any value therebetween.

[0043] In a fourth aspect, the present invention provides a use of the embedded creatine described in the second aspect of the present invention or the embedded creatine obtained by the preparation method described in the third aspect of the present invention in the field of sports nutrition.

[0044] In a fifth aspect, the present invention provides a nutritional product, which comprises the embedded creatine described in the second aspect of the present invention or the embedded creatine obtained by the preparation method described in the third aspect of the present invention.

[0045] In some embodiments, the nutritional product is selected from one or more of creatine drinks, creatine powder, creatine tablets or creatine capsules.

[0046] Compared with the prior art, the present invention has the following beneficial effects:

[0047] The invention compounds creatine with cyclodextrin, alanine and malic acid, which can improve the original effect of creatine, and has better taste and better effect. DETAILED DESCRIPTION

[0048] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with embodiments. The specific embodiments described herein are only used to explain the present invention and are not intended to constitute any limitation to the present invention.

[0049] The endpoints and any values ​​of the ranges disclosed in this article are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of each range, the endpoint values ​​of each range and the individual point values, and the individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be considered as specifically disclosed in this article.

[0050] Unless otherwise defined, the technical terms used in the following examples have the same meanings as those generally understood by those skilled in the art to which the present invention belongs. The reagents used in the following examples, unless otherwise specified, are all conventional biochemical reagents; the raw materials, instruments and equipment used in the following examples, etc., can all be purchased on the market or can be obtained by existing methods; the reagent amounts, unless otherwise specified, are the reagent amounts used in conventional experimental operations; the experimental methods, unless otherwise specified, are all conventional methods.

[0051] Example 1

[0052] First, add 300 g of water into the batching kettle and start stirring. After adding 97 g of 200-mesh creatine monohydrate, add 6 g of β-cyclodextrin, 1 g of β-alanine, and 3 g of L-malic acid and continue stirring. Stir evenly, then ultrasonicate for 1 hour to obtain a creatine monohydrate dispersion.

[0053] The dispersion enters a high-pressure homogenizer for homogenization, and the particle size of the particles in the dispersion reaches 50-300 nm after homogenization. The homogenized dispersion enters a spray dryer, and the feed flow rate is controlled to be 50-200 mL / min, the inlet air temperature is 120-125° C., and the outlet air temperature is 70-75° C. After discharging, embedded creatine monohydrate is obtained, and the creatine content is ≥90%, and the drying loss is 10.5%-12.5%.

[0054] Example 2

[0055] The difference from Example 1 is that 2 g of β-cyclodextrin is added.

[0056] Example 3

[0057] The difference from Example 1 is that 10 g of β-cyclodextrin is added.

[0058] Example 4

[0059] The difference from Example 1 is that 8 g of β-alanine is added.

[0060] Example 5

[0061] The difference from Example 1 is that 0.1 g of β-alanine is added.

[0062] Example 6

[0063] The difference from Example 1 is that 0.5 g of L-malic acid is added.

[0064] Example 7

[0065] The difference from Example 1 is that 8 g of L-malic acid is added.

[0066] Comparative Example 1

[0067] Different from Example 1, no β-alanine was added.

[0068] Comparative Example 2

[0069] Different from Example 1, no β-cyclodextrin was added.

[0070] Comparative Example 3

[0071] Different from Example 1, no L-malic acid was added.

[0072] The taste reference standard table of the present invention is shown in Table 1. The taste of the embedded creatine prepared in the above examples and comparative examples is shown in Table 2. Method for taste scoring: 3g of the product is added to 100ml of water, mixed evenly and then taken in the mouth, and then scored according to the standards shown in Table 1.

[0073] Table 1 Taste reference standard table

[0074]

[0075]

[0076] Table 2

[0077]

[0078] As shown in Table 2, the original taste of creatine can be improved by compounding β-cyclodextrin, β-alanine, L-malic acid and creatine.

[0079] The preferred embodiments of the present invention are described in detail above, but the present invention is not limited thereto. Within the technical concept of the present invention, the technical solution of the present invention can be subjected to a variety of simple modifications, including the combination of various technical features in any other suitable manner, and these simple modifications and combinations should also be regarded as the contents disclosed by the present invention and belong to the protection scope of the present invention.

Claims

1. A creatine composition comprising: Creatine, cyclodextrin, alanine and malic acid.

2. The creatine composition according to claim 1, characterized in that The creatine comprises creatine monohydrate; and / or The particle size of the creatine is 100-300 mesh; and / or The cyclodextrin comprises β-cyclodextrin; and / or The alanine comprises β-alanine; and / or The malic acid comprises L-malic acid; and / or The mass ratio of creatine to alanine is 50-120:1, preferably 80-100:1; and / or The mass ratio of cyclodextrin to alanine is 0.5-15:1, preferably 2-10:1, more preferably 5-8:1; and / or The mass ratio of alanine to malic acid is 1:0.1-10, preferably 1:0.5-5.

3. The creatine composition according to claim 1 or 2, characterized in that The composition comprises, by weight: 50-150 parts of creatine, 1-15 parts of cyclodextrin, 0.1-10 parts of alanine and 0.5-10 parts of malic acid; Preferably, the composition comprises: 50-120 parts of creatine, 2-10 parts of cyclodextrin, 0.5-8 parts of alanine and 0.5-8 parts of malic acid; Preferably, the composition comprises: 80-120 parts of creatine, 5-8 parts of cyclodextrin, 0.5-5 parts of alanine and 1-5 parts of malic acid.

4. An embedded creatine, comprising the creatine composition according to any one of claims 1 to 3.

5. A method for preparing the embedded creatine according to claim 4, comprising the following steps: (1) compounding the creatine composition according to any one of claims 1 to 3 with water to obtain a creatine dispersion; (2) homogenizing and drying the creatine dispersion to obtain the embedded creatine.

6. The preparation method according to claim 5, characterized in that: The preparation method of the creatine dispersion comprises the following steps: mixing creatine with water, and then adding alanine, malic acid and cyclodextrin to mix, so as to obtain the creatine dispersion; Preferably, the mass ratio of creatine to water is 80-120:

300.

7. The preparation method according to claim 5 or 6, characterized in that: The particle size of the microparticles in the homogenized creatine dispersion is 50-300 nm.

8. The preparation method according to any one of claims 5 to 7, characterized in that: The drying is spray drying, Preferably, the feed flow rate of the spray drying is 50 to 200 mL / min; and / or The spray drying air inlet temperature is 120-130°C, and / or The outlet air temperature of the spray drying is 70-75°C.

9. Use of the embedded creatine according to claim 4 or the embedded creatine obtained by the preparation method according to any one of claims 5 to 8 in the field of sports nutrition.

10. A nutritional product comprising the embedded creatine according to claim 4 or the embedded creatine obtained by the preparation method according to any one of claims 5 to 8; Preferably, the nutritional product is selected from one or more of creatine drinks, creatine powder, creatine tablets or creatine capsules.

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