Thyroid measurement system and measurement preparation method thereof

Abstract

The invention relates to a thyroid measuring system which comprises a smearing device, an optical camera, a thyroid counter, a base, a camera driving device, a base driving device and a control unit. The control unit is used for obtaining information of a current patient, comparing a first thyroid fluorescence image with a current thyroid fluorescence image when it is determined that the thyroid of the patient is not measured for the first time, and generating a control signal according to a comparison result, and the base driving device controls movement and rotation of the base according to the control signal. The positions of the base and the corresponding thyroid counter and the position of the optical camera are adjusted to the second position, so that the thyroid fluorescence image of this time and the thyroid fluorescence image of the first time coincide; and indicating to remove the emulsion, controlling a camera driving device to move the optical camera to the edge of the thyroid counter, and controlling the thyroid counter to detect gamma rays. According to the invention, the consistency of measurement areas of the thyroid counter for two or more times is realized.

Description

Technical Field

[0001] The invention relates to a thyroid measurement technology, and in particular to a thyroid measurement system and a measurement method thereof. Background Art

[0002] Existing thyroid counters include scintillation thyroid counters (thyroid counters for short). The detection process of a thyroid counter includes: 1) Positioning and detection: The thyroid counter is usually placed on the patient's neck, close to the thyroid gland. The thyroid counter captures the gamma rays released from the radioactive iodine in the thyroid gland. 2) Signal processing: The thyroid counter converts the captured gamma rays into electrical signals. The counter system counts these signals and records the number of gamma rays detected in a certain period of time (called the count rate).

[0003] The count rate represents the amount of radioactive iodine absorbed by the thyroid gland. Doctors analyze this data to determine the radioactive iodine uptake rate (RAIU) of the thyroid gland to assess thyroid function. In order to more accurately determine thyroid function, doctors usually perform multiple tests. By comparing multiple RAIU results over a period of time, you can better understand the dynamic changes in thyroid function.

[0004] Since the thyroid counter is a large physical entity during the actual measurement process and the interval between two measurements is long, its position relative to the patient will deviate during each measurement, which may cause problems when the measurement results are referenced to each other. Summary of the invention

[0005] In order to solve the above problems, the present application provides a thyroid measurement system in a first aspect, which comprises: A smear device, an optical camera, a thyroid counter, a base, a camera driving device, a base driving device and a control unit; the control unit is respectively connected to the optical camera, the thyroid counter, the camera driving device and the base driving device for communication; The application device is used to apply the radiation-sensitive fluorescent emulsion to the patient's neck; The camera driving device is used to drive the optical camera; The optical camera can be driven by the camera driving device to move between an initial position and a final position. In the initial position, the optical camera is located at the front center of the thyroid counter and is coaxial with the thyroid counter. The optical camera is used to take a thyroid fluorescence image after the patient applies a radiation-sensitive material and send it to the control unit. After taking the image, the optical camera is moved to the final position by the camera driving device, and the final position is located at the edge of the thyroid counter. The thyroid counter is used to detect gamma rays and is located on the base; The base is connected to a base driving device; the base driving device can drive the base to move and rotate in all directions, so that the positions of the thyroid counter on the base and the optical camera on the thyroid counter change; The control unit is configured to obtain current patient information, and when it is determined that this is not the first thyroid measurement for the patient, obtain the current thyroid fluorescence image of the patient and retrieve the first thyroid fluorescence image corresponding to the patient, and compare the first thyroid fluorescence image with the current thyroid fluorescence image, generate a control signal according to the comparison result, and send the control signal to the base drive device, which controls the movement and rotation of the base according to the control signal, thereby adjusting the position of the base and the corresponding thyroid counter and the position of the optical camera to the second position, so that the thyroid fluorescence image taken by the optical camera at the second position overlaps with the first thyroid fluorescence image corresponding to the patient; and instruct to remove the emulsion and control the camera drive device to move the optical camera to the edge of the thyroid counter, and control the thyroid counter to detect gamma rays after the emulsion is removed and the optical camera is moved to the edge of the thyroid counter.

[0006] According to some embodiments of the present invention, the control unit is further configured to obtain current patient information, and when it is determined that the patient is having a first thyroid measurement, obtain the patient's current thyroid fluorescence image and save it as the patient's first thyroid fluorescence image to be associated with the patient, and instruct the removal of emulsion and control the camera drive device to move the optical camera to the edge of the thyroid counter, and control the thyroid counter to detect gamma rays after the emulsion is removed and the optical camera is moved to the edge of the thyroid counter.

[0007] According to some embodiments of the present invention, the optical camera is further used to capture a natural image of the patient's neck before applying the radiation-sensitive material to the patient during each measurement, and send the image to the control unit.

[0008] According to some embodiments of the present invention, the base driving device includes a first track, a second track, a third track, and a first driving device, a second driving device, and a third driving device respectively located on the first track, the second track, and the third track; the base is located on the first track, and the base can slide and rotate along the first track when driven by the first driving device; the first track is located on the second track and intersects with the second track at right angles, and the first track can slide along the second track when driven by the second driving device; one end of the second track is fixed to a third track, the third track is perpendicular to the first track and the second track, and the second track can move along the third track when driven by the third driving device; the first driving device, the second driving device, and the third driving device respectively include motors and transmission mechanisms located on the first track, the second track, and the third track.

[0009] According to some embodiments of the present invention, comparing the first thyroid fluorescence image with the current thyroid fluorescence image, and generating a control signal according to the comparison result includes: Extract key points from the first thyroid fluorescence image and the current thyroid fluorescence image; find the correspondence between the images by matching feature point pairs; estimate the transformation matrix of movement and rotation using the least squares method or the RANSAC algorithm; and generate a corresponding control signal based on the transformation matrix.

[0010] According to some embodiments of the present invention, at the initial moment of comparison, the key point is selected as the center position from the first thyroid fluorescence image and the current thyroid fluorescence image to ensure that the key point exists in both, and the key point is gradually selected from the edge of the image to make the field of view and the center of the field of view of the optical camera consistent during two measurements.

[0011] According to some embodiments of the present invention, the control unit is also configured to analyze the correlation between the first thyroid fluorescence image and the first gamma-ray detection result to obtain a first correlation coefficient, and to perform a correlation analysis between the current thyroid fluorescence image and the gamma-ray detection result at the current second position to obtain a second correlation coefficient, and to compare the first correlation coefficient and the second correlation coefficient. If the difference between the two exceeds a threshold, a warning is issued to indicate that various light interferences and radiation interferences may exist in the environment.

[0012] According to some embodiments of the present invention, the control unit is also configured to perform a correlation analysis on a first natural image of the patient's neck and a natural image of the patient's neck in a current second position to determine changes in the shape of the neck, and to indicate whether there is an abnormality based on the difference between the changes in the shape of the neck, the first gamma ray detection result, and the gamma ray detection result in the current second position.

[0013] According to some embodiments of the present invention, the coating device is also communicatively connected to the control unit and includes an automatic spraying component, which can be moved to the front end center of the thyroid counter under the control of the control unit, and can spray a thyroid image corresponding to the first thyroid fluorescence image on the patient's neck with visible paint according to the control of the control unit.

[0014] The present application also provides a measurement preparation method for the thyroid system, the method comprising the following steps: S1. The patient takes a predetermined dose of radioactive iodine; S2. Apply radiation-sensitive fluorescent lotion to the patient's neck; S3. Take a thyroid fluorescence image through the optical camera at the front center of the thyroid counter and send it to the control unit; S4. The control unit obtains the current patient information, and when it is determined that the patient is having a thyroid measurement for the first time, obtains the current thyroid fluorescence image of the patient and saves it as associated with the patient; when it is determined that the patient is not having a thyroid measurement for the first time, obtains the current thyroid fluorescence image of the patient and retrieves the first thyroid fluorescence image corresponding to the patient, and compares the first thyroid fluorescence image with the current thyroid fluorescence image, generates a control signal according to the comparison result, and sends the control signal to the base drive device, which controls the movement and rotation of the base according to the control signal, thereby adjusting the position of the base and the corresponding thyroid counter and the position of the optical camera to the second position, so that the thyroid fluorescence image taken by the optical camera at the second position coincides with the first thyroid fluorescence image corresponding to the patient; S5. The control unit instructs the removal of the emulsion and controls the camera drive to move the optical camera to the edge of the thyroid counter.

[0015] When thyroid disease worsens, the neck will swell, and it is impossible to align the two thyroid counters at the same position by naked eyes. The present invention can ensure that the two thyroid counters are aligned at the same position, especially at the thyroid gland, to the greatest extent possible, and eliminate the influence of other factors other than the thyroid gland (such as neck swelling) on ​​the placement of the measurement equipment, thereby improving the accuracy and reference of multiple measurements. In addition, the present invention can also eliminate unexpected interference in the environment and improve measurement accuracy through mutual reference of gamma ray detection results and fluorescent image data. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and, together with the description, serve to explain the principles of the invention.

[0017] Figure 1 A schematic diagram showing a thyroid measurement system according to some embodiments of the present invention, wherein an optical camera is loaded at the front end of a thyroid counter; Figure 2 shows a thyroid measurement system according to some embodiments of the present invention, wherein the optical camera moves from the front end of the thyroid counter to the edge; Figure 3 A schematic diagram showing the overlap calibration of a first thyroid fluorescence image and a second thyroid fluorescence image captured by an optical camera in a thyroid measurement system according to some embodiments of the present invention is shown; Figure 4 A flow chart showing a measurement preparation method for the thyroid system is shown; Figure 5 A schematic structural block diagram of a thyroid measurement device according to some embodiments of the present invention is shown; Figure 6 A schematic structural diagram of a thyroid measurement device according to some embodiments of the present invention is shown. DETAILED DESCRIPTION

[0018] The exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. These embodiments are provided in order to enable a more thorough understanding of the present disclosure and to fully convey the scope of the present disclosure to those skilled in the art. It should be noted that, in the absence of conflict, the embodiments in this application and the features in the embodiments may be combined and referenced to each other. In addition, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments.

[0019] It should be understood that the terms used in the text are only for the purpose of describing specific example embodiments, and are not intended to be limited. Unless the context clearly indicates otherwise, the singular forms "one", "an" and "said" as used in the text may also be represented to include plural forms. For any component, data or structure mentioned in the embodiments of the present application, it is generally understood to be one or more in the absence of clear definition or in the context of giving contrary revelations. "Multiple" may refer to two or more. The terms "include", "comprise", "contain", and "have" are inclusive, and therefore specify the existence of stated features, steps, operations, elements and / or parts, but do not exclude the existence or addition of one or more other features, steps, operations, elements, parts, and / or combinations thereof.

[0020] In addition, the term "and / or" in this application is only a description of the association relationship of associated objects, indicating that there can be three relationships. For example, A and / or B can represent: A exists alone, A and B exist at the same time, and B exists alone. In addition, the character " / " in this application generally indicates that the associated objects before and after are in an "or" relationship.

[0021] Before using the thyroid measurement system of this application, the patient needs to take a predetermined dose of radioactive iodine (such as I-131 or I-123) according to the doctor's advice. The dose of radioactive iodine can be adjusted according to the patient's weight, age and thyroid function. After taking the radioactive iodine, the patient waits for a period of time to ensure that the radioactive iodine is fully absorbed by the thyroid gland.

[0022] The thyroid measurement system for multiple measurements of the present application (such as Figure 1 As shown in the figure, the thyroid gland apparatus comprises: a smearing device, an optical camera 500, a connecting piece 400, a thyroid gland counter 200, a base 100, a camera driving device 300, a base driving device, and a control unit.

[0023] The application device (not shown) is used to apply a radiation-sensitive fluorescent emulsion on the patient's neck. The radiation-sensitive fluorescent emulsion can respond to gamma rays and emit fluorescence. Since the thyroid gland releases gamma rays, the emulsion at the thyroid gland absorbs gamma rays and produces fluorescence.

[0024] The lotion may include fluorescent scintillator materials. These materials can absorb the energy of gamma rays and convert it into visible light, producing fluorescence. Common scintillator materials include sodium iodide (NaI) doped with thallium, zinc oxide (ZnO), etc. Such materials can be mixed into the lotion, and when the lotion encounters gamma rays released by radioactive iodine, it will fluoresce. In addition, some fluorescent molecules (such as organic dyes) or nanomaterials (such as quantum dots) are sensitive to electromagnetic radiation. These materials can also be mixed into the lotion and applied to the skin surface to emit light by absorbing gamma rays or beta rays.

[0025] The optical camera can be driven by the camera driving device to move between the initial position and the final position. The optical camera is in the initial position ( Figure 1 ) is located at the front center of the thyroid counter and is coaxial with the thyroid counter. It is used to capture the thyroid fluorescence image after the patient applies the radiation-sensitive material and send it to the control unit. After the capture is completed, it is moved to the final position by the camera driving device 300. The final position is located at the edge of the thyroid counter, such as Figure 2 shown.

[0026] According to some embodiments of the present invention, the optical camera may be further configured to capture a natural image of the patient's neck before applying the radiation-sensitive material to the patient during each measurement, and send the image to the control unit.

[0027] like Figure 1 As shown, the optical camera is located at the front center of the thyroid counter, so the field of view center of the optical camera is basically consistent with the detection center of the thyroid counter. Therefore, by adjusting the field of view center of the optical camera, the detection center position of the thyroid counter can be controlled.

[0028] According to some embodiments of the present invention, the system further comprises a connecting member 400, such as Figure 1 and 2 As shown, the optical camera is connected to the edge of the front end of the thyroid counter via a connector 400. After shooting is completed, the optical camera will be driven by a camera driving device to rotate to the edge to avoid any obstruction.

[0029] The thyroid counter is located on a base, which is connected to a base driving device. The base driving device can drive the base to move and rotate in all directions to change the position of the base, thereby changing the position of the thyroid counter on the base, and thereby changing the position of the optical camera fixed to the thyroid counter.

[0030] According to some embodiments of the present invention, Figure 1 and 2 As shown, the base driving device includes a first track (where the Y axis is located), a second track (where the X axis is located), a third track (where the Z axis is located), and a first driving device (not shown), a second driving device (not shown), and a third driving device (not shown) respectively located on the first track, the second track, and the third track. The base is located on the first track, and the base can slide and rotate along the first track under the drive of the first driving device; the first track is located on the second track and intersects the second track perpendicularly, and the first track can slide along the second track under the drive of the second driving device; one end of the second track is fixed on a third track, and the third track is perpendicular to the first track and the second track, and the second track can move along the third track under the drive of the third driving device; the first driving device, the second driving device, and the third driving device respectively include motors and transmission mechanisms located on the first track, the second track, and the third track. In view of the fact that the directional drive control is realized by the motor and the transmission mechanism, it is already well known, and for the sake of simplicity, it will not be repeated here, and in order to highlight the theme, it has also been omitted in the figure.

[0031] The control unit is configured to obtain current patient information, and when it is determined that this is not the first thyroid measurement for the patient, obtain the current thyroid fluorescence image of the patient and retrieve the first thyroid fluorescence image corresponding to the patient, compare the first thyroid fluorescence image with the current thyroid fluorescence image, generate a control signal according to the comparison result, and send the control signal to the base driving device, which controls the movement and rotation of the base according to the control signal, thereby adjusting the position of the base and the corresponding thyroid counter and the position of the optical camera to a second position, so that the thyroid fluorescence image taken by the optical camera at the second position overlaps with the first thyroid fluorescence image corresponding to the patient, and instructs the removal of emulsion and controls the camera driving device to move the optical camera to the edge of the thyroid counter, and controls the thyroid counter to detect gamma rays after the emulsion is removed and the optical camera is moved to the edge of the thyroid counter, and instructs the removal of emulsion, and controls the thyroid counter to detect gamma rays after the emulsion is removed.

[0032] According to some embodiments of the present invention, the first thyroid fluorescence image and the current thyroid fluorescence image are compared, and the control signal is generated according to the comparison result, which may include: extracting key points from the first thyroid fluorescence image and the current thyroid fluorescence image; finding the correspondence between the images by matching feature point pairs; estimating the transformation matrix of movement and rotation using the least squares method or the RANSAC algorithm; and generating a corresponding control signal based on the transformation matrix. By making the fluorescence images measured twice overlap, it is possible to ensure that the measurement areas of the two cameras are consistent, and that the fields of view of the two cameras overlap, thereby ensuring that the center of the thyroid counter also overlaps during the two measurements.

[0033] like Figure 3 As shown, circle A is the thyroid fluorescence image taken for the first time, and circle B is the thyroid fluorescence image taken again later. By comparing the two thyroid fluorescence images, it can be found that circle B needs to be moved toward C to achieve the overlap of the two images. Accordingly, it is necessary to control the base of the thyroid counter to move the thyroid counter together with the camera thereon toward C. According to some embodiments of the present invention, considering that the neck will swell when the thyroid disease worsens, the present invention proposes to further use the center point on the thyroid (M in the figure) as a reference point to assist in judging the overlap, and in the case of overlap of the center points, the overlap rate is greater than or equal to a certain threshold value as the overlap of the two images. Therefore, the overlap in the present invention includes the above-mentioned many relative overlap situations.

[0034] Since the present invention aims to ensure that the field of view and the center of view of the camera are consistent twice, according to some embodiments of the present invention, at the initial moment of comparison, the key point is selected from the center of the image to ensure that the key point exists in both images, and the key point is gradually selected from the edge of the image, so as to maximize the consistency of the field of view and the center of view of the optical camera when measuring twice, thereby ensuring that the field of view of the corresponding thyroid counter is consistent when measuring twice.

[0035] The control unit is located in the thyroid counter, and is configured to analyze the correlation between the first thyroid fluorescence image and the first gamma-ray detection result to obtain a first correlation coefficient, and to analyze the correlation between the current thyroid fluorescence image and the gamma-ray detection result at the current second position to obtain a second correlation coefficient, and to compare the first correlation coefficient with the second correlation coefficient. If the difference between the two exceeds a threshold, a warning is issued to indicate that various light interferences and radiation interferences may exist in the environment.

[0036] According to some embodiments of the present invention, the control unit is further configured to perform a correlation analysis between the first natural image of the patient's neck and the natural image of the patient's neck in the current second position, determine the change in neck shape, and indicate whether there is an abnormality based on the difference between the change in neck shape, the first gamma ray detection result, and the gamma ray detection result in the current second position. Since thyroid problems are usually accompanied by a swollen neck, a clear indication can be further given by finding the degree of change in neck shape through shooting and comparison.

[0037] The control unit may also be configured to obtain current patient information, obtain a thyroid fluorescence image of the patient and save it as associated with the patient when determining that the patient is undergoing the first thyroid measurement, instruct to remove the emulsion and control the camera drive device to move the optical camera to the edge of the thyroid counter, and control the thyroid counter to detect gamma rays after the emulsion is removed and the optical camera is moved to the edge of the thyroid counter. For example, the control unit may give instructions by voice, and obtain a message by voice that the emulsion has been removed and the optical camera has been moved to the edge.

[0038] According to some embodiments of the present invention, the aforementioned coating device is also connected to the control unit in communication, and includes an automatic spraying component, which can be moved to the front center of the thyroid counter under the control of the control unit, and can spray a thyroid image corresponding to the first thyroid fluorescence image on the patient's neck with visible paint according to the control of the control unit. In this way, it is convenient for the doctor to roughly adjust the alignment relationship between the thyroid counter and the patient with the naked eye. The automatic spraying component device can be moved to the front center of the thyroid counter and from it to the edge in a manner similar to an optical camera, for example, it can also be connected to the edge of the front end of the thyroid counter through a connector 400.

[0039] According to some embodiments of the present invention, the automatic spraying component can also be used to selectively spray radiation-sensitive fluorescent emulsion, thereby avoiding the aforementioned manual application. This can be achieved, for example, by configuring the spray pipe to include both a visible paint spray pipe and a radiation-sensitive fluorescent emulsion spray pipe.

[0040] According to some embodiments of the present invention, the control unit is further configured to control various components communicatively connected thereto via wired or wireless signals.

[0041] When thyroid disease worsens, the neck will swell, and it is impossible to align the two thyroid counters at the same position by naked eyes. The present invention can ensure that the two thyroid counters are aligned at the same position, especially at the thyroid gland, to the greatest extent possible, and eliminate the influence of other factors other than the thyroid gland (such as neck swelling) on ​​the placement of the measurement equipment, thereby improving the accuracy and reference of multiple measurements. In addition, the present invention can also eliminate unexpected interference in the environment and improve measurement accuracy through mutual reference of gamma ray detection results and fluorescent image data.

[0042] The second aspect of the present application also proposes a measurement preparation method for the thyroid system, the method comprising the following steps: S1. The patient receives a predetermined dose of radioactive iodine.

[0043] Patients take a predetermined dose of radioactive iodine (such as I-131 or I-123) based on their doctor's advice. The dose of radioactive iodine can be adjusted based on the patient's weight, age, and thyroid function. After taking the radioactive iodine, patients wait for a period of time to ensure that the radioactive iodine is fully absorbed by the thyroid gland.

[0044] S2. Apply radiation-sensitive fluorescent lotion to the patient's neck.

[0045] The emulsion absorbs gamma rays at the thyroid gland and produces a fluorescent signal. Since the thyroid gland releases gamma rays, the emulsion at the thyroid gland absorbs gamma rays and produces a fluorescent signal.

[0046] S3. Take a thyroid fluorescence image through the optical camera at the front center of the thyroid counter and send it to the control unit.

[0047] S4. The control unit obtains the current patient information, and when it is determined that this is the first time for the patient to have a thyroid measurement, obtains the patient's current thyroid fluorescence image and saves it as associated with the patient; when it is determined that this is not the first time for the patient to have a thyroid measurement, obtains the patient's current thyroid fluorescence image and calls up the first thyroid fluorescence image corresponding to the patient, compares the first thyroid fluorescence image with the current thyroid fluorescence image, generates a control signal based on the comparison result, and sends the control signal to the base drive device, which controls the movement and rotation of the base based on the control signal, thereby adjusting the position of the base and the corresponding thyroid counter and the position of the optical camera to the second position, so that the thyroid fluorescence image taken by the optical camera at the second position coincides with the first thyroid fluorescence image corresponding to the patient.

[0048] According to some embodiments of the present invention, the first thyroid fluorescence image and the current thyroid fluorescence image are compared, a control signal is generated according to the comparison result, and the control signal is sent to the base drive device, and the base drive device controls the movement and rotation of the base according to the control signal, which can include: extracting key points from the first thyroid fluorescence image and the current thyroid fluorescence image; finding the correspondence between the images by matching feature point pairs; estimating the transformation matrix of movement and rotation using the least squares method or the RANSAC algorithm; generating a corresponding control signal based on the transformation matrix to control the movement and rotation of the base drive device. By making the fluorescence images measured twice overlap, it can be ensured that the measurement areas of the two cameras are consistent, and that the fields of view of the two cameras overlap, thereby ensuring that the center of the thyroid counter also overlaps during the two measurements.

[0049] Since the present invention aims to ensure the consistency of the camera's field of view and field of view center twice, according to some embodiments of the present invention, at the beginning of the comparison, the key point is selected from the center of the image to ensure that the key point exists in both images, and the key point is gradually selected from the edge of the image, so as to maximize the consistency of the front and rear fields of view and field of view center, thereby also ensuring that the field of view center of the corresponding thyroid counter is consistent.

[0050] The image overlap here includes making the contour edges of the two images overlap, so that the fields of view and fields of view centers of the two cameras before and after are consistent, thereby also ensuring that the fields of view centers of the corresponding thyroid counters are consistent.

[0051] S5. The control unit instructs the removal of the emulsion and controls the camera drive to move the optical camera to the edge of the thyroid counter.

[0052] The thyroid counter is placed in front of the patient's neck. By moving the optical camera from the center of the front end of the thyroid counter to the edge of the front end of the thyroid counter, the thyroid counter can detect the gamma ray signal released by the radioactive iodine. Since the optical camera is at the edge of the front end of the thyroid counter, it will not affect the field of view of the thyroid counter.

[0053] The above process prepares for the subsequent thyroid counter work, so that the subsequent measurement can ensure that the two thyroid counters are aligned with the same position, especially the thyroid gland, to the greatest extent possible, and exclude the influence of other factors other than the thyroid gland (such as neck swelling) on ​​the placement of the measurement equipment as much as possible, thereby improving the accuracy and reference of multiple measurements before and after. In addition, the present invention also makes it possible to eliminate unexpected interference in the environment and improve measurement accuracy through mutual reference of gamma ray detection results and fluorescence image data.

[0054] In addition, according to some embodiments of the present invention, the method may also include analyzing the correlation between the first thyroid fluorescence image and the first gamma ray detection result to obtain a first correlation coefficient, and analyzing the correlation between the current thyroid fluorescence image and the current gamma ray detection result to obtain a second correlation coefficient, comparing the first correlation coefficient and the second correlation coefficient, and if the difference between the two exceeds a threshold, issuing a warning to indicate that various light interference and radiation interference may exist in the environment. In the above manner, various measurement errors or serious errors introduced by unexpected interference in the two measurements can be eliminated, thereby ensuring the accuracy of the measurement.

[0055] Figure 5 FIG. 5 shows a schematic structural block diagram of a thyroid measurement device 5000 according to some embodiments of the present invention. Figure 5 As shown, the thyroid measurement device 5000 may include: a patient information acquisition unit 5001 , a judgment and image acquisition unit 5002 , and a control instruction output unit 5003 .

[0056] The patient information acquisition unit 5001 is used to acquire current patient information.

[0057] The judgment and image acquisition unit 5002 is used to obtain the current thyroid fluorescence image of the patient and save it as associated with the patient when it is determined that the patient is having the first thyroid measurement; when it is determined that the patient is not having the first thyroid measurement, obtain the current thyroid fluorescence image of the patient and call up the first thyroid fluorescence image corresponding to the patient, and compare the first thyroid fluorescence image with the current thyroid fluorescence image, and generate a control signal according to the comparison result; The control instruction output unit 5003 is used to send a control signal to the base driving device, and the base driving device controls the movement and rotation of the base according to the control signal, thereby adjusting the position of the base and the corresponding thyroid counter and the position of the optical camera to a second position, so that the thyroid fluorescence image taken by the optical camera at the second position coincides with the first thyroid fluorescence image corresponding to the patient.

[0058] The control instruction output unit is also used for instructing to remove the emulsion and controlling the camera driving device to move the optical camera to the edge of the thyroid counter.

[0059] The corresponding detailed descriptions made with reference to the various figures above are included here by reference, and more corresponding detailed functions can be realized by adding corresponding functional units or modules, or by further limiting the above units, which will not be repeated here.

[0060] Figure 6 FIG. 6 is a schematic structural diagram of a thyroid measurement device 6000 according to some embodiments of the present invention. Figure 6As shown, the device includes a processor 6051, a memory 6052 and a bus 6053.

[0061] In some examples, the device may also include an input device 6001, an input port 6002, an output port 6003, and an output device 6004. The input port 6002, the processor 6051, the memory 6052, and the output port 6003 are connected via a bus 6053, and the input device 6001 and the output device 6004 are connected to the bus 6053 via the input port 6002 and the output port 6003, respectively, and then connected to other components of the device. It should be noted that the output interface and the input interface here can also be represented by an I / O interface. Specifically, the input device 6001 receives input information from the outside, and transmits the input information to the processor 6051 via the input port 6002; the processor 6051 processes the input information based on the computer executable instructions stored in the memory 6052 to generate output information, temporarily or permanently stores the output information in the memory 6052, and then transmits the output information to the output device 6004 via the output port 6003.

[0062] The above-mentioned memory 6052 includes a large capacity memory for data or instructions. For example, but not limitation, the memory 6052 may include a HDD, a floppy disk drive, a flash memory, an optical disk, a magneto-optical disk, a tape or a universal serial bus (USB) drive or a combination of two or more of these. In appropriate cases, the memory 6052 may include a removable or non-removable (or fixed) medium. In appropriate cases, the memory 6052 may be inside or outside the device. In a specific embodiment, the memory 6052 is a non-volatile solid-state memory. In a specific embodiment, the memory 6052 includes a read-only memory (ROM). In appropriate cases, the ROM may be a mask-programmed ROM, a programmable ROM (PROM), an erasable PROM (EPROM), an electrically erasable PROM (EEPROM), an electrically rewritable ROM (EAROM) or a flash memory or a combination of two or more of these.

[0063] The bus 6053 includes hardware, software or both, coupling the components to each other. For example and not limitation, the bus 6053 may include an accelerated graphics port (AGP) or other graphics bus, an enhanced industry standard architecture (EISA) bus, a front-side bus (FSB), a hypertransport (HT) interconnect, an industry standard architecture (ISA) bus, an infinite bandwidth interconnect, a low pin count (LPC) bus, a memory bus, a microchannel architecture (MCA) bus, a peripheral component interconnect (PCI) bus, a PCI-Express (PCI-X) bus, a serial advanced technology attachment (SATA) bus, a video electronics standard association local (VLB) bus or other suitable bus or a combination of two or more of these. Although the embodiments of the present invention describe and illustrate a specific bus, the present invention contemplates any suitable bus or interconnect.

[0064] The processor 6051 performs the following actions based on the computer program stored in the memory 6052: Acquire the current patient information, and when it is determined that the patient is having the first thyroid measurement, acquire the current thyroid fluorescence image of the patient and save it as associated with the patient; when it is determined that this is not the first thyroid measurement for the patient, acquire the current thyroid fluorescence image of the patient and retrieve the first thyroid fluorescence image corresponding to the patient, compare the first thyroid fluorescence image with the current thyroid fluorescence image, generate a control signal according to the comparison result, and send the control signal to the base drive device, which controls the movement and rotation of the base according to the control signal, thereby adjusting the position of the base and the corresponding thyroid counter and the position of the optical camera to the second position, so that the thyroid fluorescence image taken by the optical camera at the second position coincides with the first thyroid fluorescence image corresponding to the patient; instruct to remove the emulsion and control the camera drive device to move the optical camera to the edge of the thyroid counter.

[0065] According to some further embodiments of the present invention, the computer program may be divided into one or more units in various ways and stored in the memory, and executed by the processor to complete the present invention. The one or more units may be a series of computer program instruction segments capable of completing specific functions, and the instruction segments are used to describe the execution process of the computer program in the device. The computer program may be divided into one or more units in various ways and stored in the memory, and executed by the processor to complete the present invention. The one or more units may be a series of computer program instruction segments capable of completing specific functions, and the instruction segments are used to describe the execution process of the computer program in the device. Figure 5 The functions of each unit in each embodiment described are divided into multiple units, or include the aforementioned reference Figure 5 For the sake of simplicity, the various units in the various embodiments described are not repeated here.

[0066] The processor may be a central processing unit (CPU), or other general-purpose processors, digital signal processors (DSP), application-specific integrated circuits (ASIC), field-programmable gate arrays (FPGA) or other programmable logic devices, discrete gates or transistor logic devices, discrete hardware components, etc. A general-purpose processor may be a microprocessor or the processor may be any conventional processor, etc. The processor is the control center of the device, and various interfaces and lines are used to connect the various parts of the entire device. The device may be a computing device such as a desktop computer, a notebook, a PDA, and a cloud server, or a part thereof. The device may include, but is not limited to, a processor and a memory. Those skilled in the art will appreciate that the schematic diagram is merely an example of a device and does not constitute a limitation on the device.

[0067] The corresponding detailed descriptions made above with reference to the various figures are incorporated herein by reference and will not be repeated here.

[0068] The present application also proposes a computer-readable storage medium, wherein the computer-readable storage medium stores a computer program, wherein when the computer program is executed by a processor, the following steps are implemented: Acquire the current patient information, and when it is determined that the patient is having the first thyroid measurement, acquire the current thyroid fluorescence image of the patient and save it as associated with the patient; when it is determined that this is not the first thyroid measurement for the patient, acquire the current thyroid fluorescence image of the patient and retrieve the first thyroid fluorescence image corresponding to the patient, compare the first thyroid fluorescence image with the current thyroid fluorescence image, generate a control signal according to the comparison result, and send the control signal to the base drive device, which controls the movement and rotation of the base according to the control signal, thereby adjusting the position of the base and the corresponding thyroid counter and the position of the optical camera to the second position, so that the thyroid fluorescence image taken by the optical camera at the second position coincides with the first thyroid fluorescence image corresponding to the patient; instruct to remove the emulsion and control the camera drive device to move the optical camera to the edge of the thyroid counter.

[0069] The corresponding detailed descriptions made above with reference to the various figures are incorporated herein by reference and will not be repeated here.

[0070] The computer program includes computer program code, which may be in source code form, object code form, executable file or some intermediate form, etc. The computer readable medium may include: any entity or device capable of carrying the computer program code, recording medium, USB flash drive, mobile hard disk, magnetic disk, optical disk, computer memory, read-only memory (ROM), random access memory (RAM), electric carrier signal, telecommunication signal and software distribution medium, etc.

[0071] It should be noted that although the structure of the apparatus of the present invention and the method of its operation are described in a specific order in the accompanying drawings, this does not require or imply that these operations must be performed in this specific order, or that all the operations shown must be performed to achieve the desired results. On the contrary, the steps depicted in the flow chart can be changed in the order of execution. Additionally or alternatively, some steps can be omitted, multiple steps can be combined into one step, and / or one step can be decomposed into multiple steps.

[0072] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A thyroid measurement system comprising: An applicator, an optical camera, a thyroid counter, a base, a camera drive, a base drive, and a control unit; The control unit is communicatively connected with the optical camera, the thyroid counter, the camera driving device, and the base driving device respectively; The application device is used to apply the radiation-sensitive fluorescent emulsion to the patient's neck; The camera driving device is used to drive the optical camera; The optical camera can be driven by the camera driving device to move between an initial position and a final position. In the initial position, the optical camera is located at the front center of the thyroid counter and is coaxial with the thyroid counter. The optical camera is used to take a thyroid fluorescence image after the patient applies a radiation-sensitive material and send it to the control unit. After taking the image, the optical camera is moved to the final position by the camera driving device, and the final position is located at the edge of the thyroid counter. The thyroid counter is used to detect gamma rays and is located on the base; The base is connected to a base driving device; the base driving device can drive the base to move and rotate in all directions, so that the positions of the thyroid counter on the base and the optical camera on the thyroid counter change; The control unit is configured to obtain current patient information, and when it is determined that this is not the first thyroid measurement for the patient, obtain the current thyroid fluorescence image of the patient and retrieve the first thyroid fluorescence image corresponding to the patient, and compare the first thyroid fluorescence image with the current thyroid fluorescence image, generate a control signal according to the comparison result, and send the control signal to the base drive device, which controls the movement and rotation of the base according to the control signal, thereby adjusting the position of the base and the corresponding thyroid counter and the position of the optical camera to the second position, so that the thyroid fluorescence image taken by the optical camera at the second position coincides with the first thyroid fluorescence image corresponding to the patient; and instructing to remove the emulsion and controlling the camera drive device to move the optical camera to the edge of the thyroid counter, and controlling the thyroid counter to detect gamma rays after the emulsion is removed and the optical camera is moved to the edge of the thyroid counter.

2. The measurement system according to claim 1, wherein: The control unit is also configured to obtain current patient information, and when it is determined that the patient is having a first thyroid measurement, obtain the patient's current thyroid fluorescence image and save it as the patient's first thyroid fluorescence image to be associated with the patient, and instruct removal of emulsion and control the camera drive device to move the optical camera to the edge of the thyroid counter, and control the thyroid counter to detect gamma rays after the emulsion is removed and the optical camera is moved to the edge of the thyroid counter.

3. According to the measurement system of claim 2, the optical camera is also used to capture a natural image of the patient's neck before applying the radiation-sensitive material to the patient during each measurement, and send it to the control unit.

4. A measuring system according to claim 1, 2 or 3, wherein: The base driving device comprises a first track, a second track, a third track, and a first driving device, a second driving device and a third driving device respectively located on the first track, the second track and the third track. The base is located on the first track, and the base can slide and rotate along the first track under the drive of the first driving device. The first track is located on the second track and intersects the second track vertically, and the first track can slide along the second track under the drive of the second driving device; One end of the second track is fixed on a third track, the third track is perpendicular to the first track and the second track, and the second track can move along the third track under the drive of a third driving device; the first driving device, the second driving device and the third driving device respectively include motors and transmission mechanisms located on the first track, the second track and the third track.

5. The measurement system according to claim 2, wherein: The first thyroid fluorescence image is compared with the current thyroid fluorescence image, and the control signal generated according to the comparison result includes: Extract key points from the first thyroid fluorescence image and the current thyroid fluorescence image; find the correspondence between the images by matching feature point pairs; estimate the transformation matrix of movement and rotation using the least squares method or the RANSAC algorithm; and generate a corresponding control signal based on the transformation matrix.

6. The measurement system according to claim 1, wherein: At the initial moment of comparison, the key point is selected as the center position of the first thyroid fluorescence image and the current thyroid fluorescence image to ensure that the key point exists in both, and the key point is gradually selected from the edge of the image to make the field of view and the center of the field of view of the optical camera consistent during the two measurements.

7. The measurement system according to claim 4, wherein: The control unit is also configured to analyze the correlation between the first thyroid fluorescence image and the first gamma-ray detection result to obtain a first correlation coefficient, and to analyze the correlation between the current thyroid fluorescence image and the gamma-ray detection result at the current second position to obtain a second correlation coefficient, and to compare the first correlation coefficient with the second correlation coefficient. If the difference between the two exceeds a threshold, a warning is issued to indicate that various light interferences and radiation interferences may exist in the environment.

8. The measurement system according to claim 3, wherein: The control unit is also configured to perform a correlation analysis between the first natural image of the patient's neck and the natural image of the patient's neck in the current second position, determine the change in the neck shape, and indicate whether there is an abnormality based on the difference between the change in the neck shape, the first gamma ray detection result, and the gamma ray detection result in the current second position.

9. The measurement system according to claim 1, wherein: The coating device is also communicatively connected to the control unit and includes an automatic spraying component, which can be moved to the front center of the thyroid counter under the control of the control unit, and can spray a thyroid image corresponding to the first thyroid fluorescence image on the patient's neck with visible paint according to the control of the control unit.

10. A method for preparing a measurement of the thyroid system according to any one of claims 1 to 9, the method comprising the following steps: S1. The patient takes a predetermined dose of radioactive iodine; S2. Apply radiation-sensitive fluorescent lotion to the patient's neck; S3. Take a thyroid fluorescence image through the optical camera at the front center of the thyroid counter and send it to the control unit; S4. The control unit obtains the current patient information, and when it is determined that the patient is undergoing the first thyroid measurement, obtains the current thyroid fluorescence image of the patient and saves it as associated with the patient; When it is determined that this is not the first thyroid measurement for the patient, the current thyroid fluorescence image of the patient is obtained and the first thyroid fluorescence image corresponding to the patient is retrieved, and the first thyroid fluorescence image is compared with the current thyroid fluorescence image, a control signal is generated according to the comparison result, and the control signal is sent to the base driving device, and the base driving device controls the movement and rotation of the base according to the control signal, so as to adjust the position of the base and the corresponding thyroid counter and the position of the optical camera to the second position, so that the thyroid fluorescence image taken by the optical camera at the second position coincides with the first thyroid fluorescence image corresponding to the patient; S5. The control unit instructs the removal of the emulsion and controls the camera drive to move the optical camera to the edge of the thyroid counter.

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