Anti-hair loss essence and preparation method thereof

Abstract

The invention relates to the field of scalp nourishing, and discloses an anti-hair-loss essence and a preparation method thereof.The anti-hair-loss essence comprises a component A, a component B, a component C, a component D and a component E. The component A comprises, by weight, 0.4-0.6% of a thickening agent, 0.3-0.7% of a humectant and the balance solvent; the component B comprises the following components in percentage by weight: 1.5-3.5% of a skin protective agent (1), 0.3-0.7% of nicotinamide and 0.08-0.12% of a skin protective agent (2); the component C comprises the following components in percentage by weight: 35%-45% of a solvent, 0.1%-0.3% of an aromatic agent, 0.03%-0.07% of tetrahydropiperine and 0.005%-0.015% of sophocarpidine; a component D: 4-6% of an anti-hair loss agent and 0.3-1.0% of a preservative; a component E: 0.01-0.1% of a skin penetrating agent; the traditional Chinese medicine composition has the advantages of improving the absorption effect of scalp on the traditional Chinese medicine composition, improving scalp health and reducing alopecia.

Description

Technical Field

[0001] The present application relates to the technical field of scalp nourishment, and in particular to an anti-hair loss essence and a preparation method thereof. Background Art

[0002] With the development of society, the pressure of life and work is increasing day by day. In addition, due to irregular work and rest schedules, environmental pollution and other external factors, more and more people are suffering from hair loss in my country, and the age of hair loss is getting younger and younger, which makes people have to pay attention to the problem of hair loss. At present, the cost of anti-hair loss drugs and hair transplantation is high. During the treatment process, if the hair is not properly cared for or is stimulated by external factors, it may cause hair loss again.

[0003] In order to prevent or improve hair loss, anti-hair loss products containing Chinese herbal extracts have appeared on the market, which greatly reduce the irritation of drugs to the scalp, and can improve scalp health, improve hair quality, and play a role in preventing hair loss and promoting hair growth. However, due to the insufficient absorption of Chinese herbal extracts by the scalp, it is easy to cause waste of Chinese herbal extracts, making the effect of preventing hair loss and promoting hair growth far from the theory. Summary of the invention

[0004] In order to improve the absorption effect of the traditional Chinese medicine composition by the scalp, the present application provides an anti-hair loss essence and a preparation method thereof.

[0005] In the first aspect, the present application provides an anti-hair loss essence lotion, which adopts the following technical solution: An anti-hair loss essence lotion, comprising component A, component B, component C, component D and component E, the total weight percentage of raw materials in each component is 100%, and the weight percentage of each component added is as follows: Component A: 0.4-0.6% thickener, 0.3-0.7% moisturizer, and the solvent is added to 100% of the weight of the anti-hair loss essence, and the solvent is water; Component B: skin protectant (1) 1.5-3.5%, niacinamide 0.3-0.7%, skin protectant (2) 0.08-0.12%; The skin protectant (1) is prepared from the following raw materials in percentage by weight: 3-7% of Polygonum multiflorum root extract, 2-4% of propylene glycol, 0.4-0.8% of 1,2-hexanediol, 0.4-0.7% of phenoxyethanol, 0.04-0.08% of ethylhexylglycerin, and water is added to 100% of the weight of the skin protectant (1); The skin protectant (2) is prepared from the following raw materials in percentage by weight: 10-20% glycerin, 1-4% tea extract, 0.4-0.8% 1,2-hexanediol, 0.3-0.7% phenoxyethanol, 0.04-0.08% ethylhexylglycerol, and water is added to 100% of the weight of the skin protectant (2); Component C: solvent 35-45%, aromatic agent 0.1-0.3%, tetrahydropiperine 0.03-0.07%, matrine 0.005-0.015%; Component D: anti-hair loss agent 4-6%, preservative 0.3-1.0%; The anti-hair loss agent is prepared from the following raw materials in percentage by weight: 15-21% 1,3-propylene glycol, 15-21% orientalis leaf extract, 0.4-0.8% hydrogenated castor oil, 0.08-0.12% EDTA-disodium, and water is added to 100% of the weight of the anti-hair loss agent; component E: 0.01-0.1% skin penetrant; the skin penetrant is prepared from the following raw materials in percentage by weight: 50-90% poloxamer and 10-50% sodium hyaluronate.

[0006] By adopting the above technical scheme, this application mainly reduces hair loss by repairing hair follicles and soothing the scalp, and improving the health level of the scalp and hair follicles. Poloxamer is a new type of high molecular non-ionic surfactant, which is a polyoxyethylene polyoxypropylene ether block polymer. It is often used as a pharmaceutical excipient for oral use. It can play the role of emulsification stabilization, solubilization, absorption promotion, sustained release, solid dispersant, etc. It is non-irritating to the skin and non-hemolytic. Studies have found that when poloxamer and sodium hyaluronate are used simultaneously in anti-hair loss essence, the mutual synergistic effect of the two substances greatly improves the anti-hair loss effect of the anti-hair loss essence. Sodium hyaluronate is a physiologically active substance widely present in animals and humans, and is distributed in human skin, synovial fluid, umbilical cord, aqueous humor and vitreous body. It was applied to anti-hair loss essence and found that it can moisturize the scalp very well. When added with poloxamer, it was found that sodium hyaluronate can play the role of penetration and introduction liquid. Poloxamer itself also has good biocompatibility, which can introduce poloxamer into the pores, open the pores, and relax them, so that macromolecular nutrients can better enter the deep layers of the skin, thereby promoting the absorption of nutrients. The moisturizing effect of sodium hyaluronate can moisturize the area around the hair follicles, prevent nutrients from being lost, prolong the action time of nutrients, and improve the health of the scalp.

[0007] Preferably, the skin permeation agent is made from the following raw materials in parts by weight: 70% poloxamer and 30% sodium hyaluronate.

[0008] By adopting the above technical solution, the addition ratio of poloxamer and sodium hyaluronate is also a very critical influencing factor. By adjusting the ratio, the anti-hair loss effect of the anti-hair loss essence can be optimized.

[0009] Preferably, the poloxamer is a polypeptide-modified poloxamer.

[0010] By adopting the above technical solution, although poloxamer itself has good biocompatibility, its physiological activity is insufficient, so sodium hyaluronate is needed to work synergistically to make up for its physiological activity and play a role in penetration and absorption. After modification with polypeptides, polypeptides can penetrate the dermis, increase collagen, and reverse skin aging by reconstruction from the inside out. Modifying polypeptides into the molecular structure of poloxamer can make poloxamer have certain physiological activity, so that it can have a stronger synergistic effect with sodium hyaluronate, and further promote the absorption of nutrients by the scalp.

[0011] Preferably, the preparation method of the polypeptide-modified poloxamer is as follows: S1, reacting the polypeptide with thionyl chloride to obtain a polypeptide acyl chloride hydrochloride intermediate; S2. reacting poloxamer with the polypeptide acyl chloride hydrochloride intermediate to obtain polypeptide-modified poloxamer.

[0012] By adopting the above technical scheme, the yield of the target product can be improved by acylating the polypeptide and then reacting it with poloxamer.

[0013] Preferably, the polypeptide is palmitoyl pentapeptide-4.

[0014] By adopting the above technical scheme, considering that the molecular structure of palmitoyl tripeptide-4 has a strong conjugation effect with the molecular structure of poloxamer, the molecular chain of the polypeptide is not suitable to fully exert its effect, and the effect of polypeptide modification of poloxamer is not as good as palmitoyl pentapeptide-4.

[0015] Preferably, the average molecular weight of the poloxamer is 8350-11500.

[0016] By adopting the above technical solution, the molecular weight is too small and the ability to open pores is poor. When it is within this range, the effect is better.

[0017] Preferably, the preservative is made from the following raw materials in parts by weight: 85-95% phenoxyethanol and 5-15% ethylhexylglycerin.

[0018] In a second aspect, the present application provides a method for preparing an anti-hair loss essence, using the following technical solution: A method for preparing an anti-hair loss essence, comprising the following steps: S1. Weigh the raw materials of component B and component C according to the amount, and premix them to obtain a premixed solution of component B and a premixed solution of component C; S2. Weigh the raw materials of component A, stir and mix, and heat to 75-90°C, keep warm and stir until swollen and transparent; S3, stirring and cooling to 55-65°C, adding the premixed liquid of component B, stirring evenly; then adding the premixed liquid of component C, stirring evenly; S4. Stir and cool to below 45°C, add the raw materials of component D and component E, stir evenly, and obtain the anti-hair loss essence.

[0019] By adopting the above technical scheme, the preparation method of the present application does not require special equipment or improvement of existing equipment, is highly tolerant to parameters of the preparation process, is suitable for mass production in factories, and the products obtained are highly uniform, have a high pass rate, and meet production standards.

[0020] In summary, the present application includes at least one of the following beneficial technical effects: 1. This application mainly reduces hair loss by repairing hair follicles and soothing the scalp, improving the health level of the scalp and hair follicles. Poloxamer and sodium hyaluronate are applied to the anti-hair loss essence at the same time. The mutual synergistic effect of the two substances greatly improves the anti-hair loss effect of the anti-hair loss essence. Sodium hyaluronate is a physiologically active substance widely present in animals and humans, and is distributed in human skin, synovial fluid, umbilical cord, aqueous humor and vitreous body of the eye. It is applied to the anti-hair loss essence, and it is found that it can have a very good moisturizing effect on the scalp. It is added together with poloxamer, and it is found that sodium hyaluronate can play the role of penetration and introduction fluid, and poloxamer itself also has good biocompatibility, and poloxamer can be introduced into the pores to open the pores and relax them, thereby promoting the absorption of nutrients. The moisturizing effect of sodium hyaluronate can moisturize the area around the hair follicles, make nutrients not easy to lose, prolong the action time of nutrients, and improve the health level of the scalp.

[0021] 2. Although poloxamer itself has good biocompatibility, its physiological activity is insufficient, so sodium hyaluronate is needed to work synergistically to make up for its physiological activity and play a role in penetration and absorption. After modification with polypeptides, polypeptides can penetrate the dermis, increase collagen, and reverse skin aging through reconstruction from the inside out. Modifying polypeptides into the molecular structure of poloxamer can make poloxamer have certain physiological activity, so that it can have a stronger synergistic effect with sodium hyaluronate, and further promote the scalp's absorption of nutrients.

[0022] 3. Using the anti-hair loss essence prepared in this application for 28 days can effectively reduce the TEWL of the scalp by up to 4.59 g / h / m 2 , scalp elasticity can be increased by up to 0.16, and hair loss can be significantly reduced after 12 weeks of use. DETAILED DESCRIPTION

[0023] The present application is further described in detail below in conjunction with the specific contents.

[0024] raw material The raw materials used in the preparation examples and embodiments of the present application can all be purchased commercially, among which the water used is deionized water; the water solubility of Platycladus orientalis leaf extract is fully water-soluble, with a specification of 10:1; the model of hydrogenated castor oil is PEG-40; the model of Polygonum multiflorum root extract is LZ-HSWTQW; the brand of sodium polyacryloyldimethyl taurate is Gulet; the effective substance content of betaine is 99%; niacinamide is food grade; the item number of tea extract is BJN0893; the grade of tetrahydropiperine is food grade; the content of matrine is 90%; the essence is rose essence, model A76454.

[0025] Preparation Example Preparation Example 1 A polypeptide-modified poloxamer, the preparation method of which is as follows: S1. Under anhydrous conditions, 47 g of polypeptide was added to 50 g of DMF, wherein the polypeptide was palmitoyl pentapeptide-4, and the mixture was stirred until dissolved. Under stirring, 8 g of thionyl chloride was added dropwise in an ice-water bath for half an hour. After the addition was completed, the mixture was heated to 50° C., stirred for reaction for 2 hours, cooled to 20° C., 70 mL of anhydrous ether was added, stirred, filtered, washed with anhydrous ether, and dried at 50° C. to obtain a polypeptide acyl chloride hydrochloride intermediate; S2. Add 200 g of poloxamer and the polypeptide acyl chloride hydrochloride intermediate obtained in S1 to 200 g of DMF, stir until dissolved, then dropwise add 6 g of triethylamine, raise the temperature to 85°C, stir and react for 15 h, add 50 g of toluene, distill under reduced pressure to remove the solvent, then add 100 mL of anhydrous ether, stir for 10 min, filter, wash with anhydrous ether, and dry to obtain polypeptide-modified poloxamer. The yield is 80.1% calculated on the basis of the polypeptide; wherein the average molecular weight of the poloxamer is 8350.

[0026] Preparation Example 2 A polypeptide-modified poloxamer is different from Preparation Example 1 in that the average molecular weight of the poloxamer is 11,500, and the remaining steps are the same as Preparation Example 1.

[0027] Preparation Example 3 A polypeptide-modified poloxamer is different from Preparation Example 1 in that the polypeptide is palmitoyl tripeptide-1, and the remaining steps are the same as Preparation Example 1. Example

[0028] Example 1 An anti-hair loss essence lotion comprises component A, component B, component C, component D and component E, wherein the raw materials and the amount of the raw materials are shown in Table 1, component A comprises raw materials 1, 6 and 7, component B comprises 4, 8 and 10, component C comprises 2, 9, 11 and 12, component D comprises 3 and 5, and component E comprises 13; the preparation method of the anti-hair loss essence lotion is as follows: S1. Weigh the raw materials of each component according to the amount in Table 1. The premix of component B is prepared as follows: take a clean container, stir the weighed raw materials of component B at room temperature until they are completely dissolved and set aside; the premix of component C is prepared as follows: take a clean container, stir the weighed raw materials of component C at room temperature until they are completely dissolved and set aside; S2. Weigh the raw materials of component A according to the amounts in Table 1 and add them into the production tank; S3, heat with stirring to 85±2℃, keep stirring until completely swollen and transparent, speed 30r / min; S4, stirring and cooling to 60±2℃, adding the premixed liquid of component B into the production tank, stirring evenly, rotating at 30r / min; adding the premixed liquid of component C into the production tank, stirring evenly, rotating at 30r / min; S5, stirring and cooling to below 45°C, adding the raw materials of component D and component E into the production tank, stirring evenly, and rotating at a speed of 30r / min; S6. Discharging the materials, that is, semi-finished products are obtained. Semi-finished products are inspected and filled if they are qualified. Finished products are inspected and put into storage if they are qualified.

[0029] Among them, the average molecular weight of poloxamer is 8350.

[0030] Table 1 Raw materials and amounts of raw materials in Example 1 Example 2 An anti-hair loss essence lotion, which is different from Example 1 in that its poloxamer is a polypeptide-modified poloxamer, the polypeptide-modified poloxamer comes from Preparation Example 1, and the remaining steps are the same as those of Example 1.

[0031] Example 3 An anti-hair loss essence lotion, which is different from Example 1 in that its poloxamer is a polypeptide-modified poloxamer, the polypeptide-modified poloxamer comes from Preparation Example 2, and the remaining steps are the same as those of Example 1.

[0032] Example 4 An anti-hair loss essence lotion, which is different from Example 1 in that its poloxamer is a polypeptide-modified poloxamer, the polypeptide-modified poloxamer comes from Preparation Example 3, and the remaining steps are the same as those of Example 1.

[0033] Example 5 An anti-hair loss essence lotion, which is different from Example 2 in that the mass percentage of the polypeptide-modified poloxamer and sodium hyaluronate is 50:50, and the remaining steps are the same as Example 2.

[0034] Example 6 An anti-hair loss essence lotion, which is different from Example 2 in that the mass percentage of the polypeptide-modified poloxamer to sodium hyaluronate is 90:10, and the remaining steps are the same as those of Example 2.

[0035] Example 7 An anti-hair loss essence lotion is different from Example 2 in that the added amount of its E component, i.e., raw material 13, is 0.01 kg, and the remaining steps are the same as Example 2.

[0036] Example 8 An anti-hair loss essence lotion is different from Example 2 in that the added amount of its E component, i.e., raw material 13, is 0.1 kg, and the remaining steps are the same as Example 2.

[0037] Comparative Example Comparative Example 1 An anti-hair loss essence lotion is different from Example 1 in that poloxamer is not added to its E component, and the remaining steps are the same as those of Example 1.

[0038] Comparative Example 2 An anti-hair loss essence lotion is different from Example 1 in that sodium hyaluronate is not added to its E component, and the remaining steps are the same as those of Example 1.

[0039] Comparative Example 3 An anti-hair loss essence lotion is different from Example 1 in that component E is not added to the anti-hair loss essence lotion, and the remaining steps are the same as those of Example 1.

[0040] Performance testing Detection method / test method According to the preparation methods in Examples 1-8 and Comparative Examples 1-3, anti-hair loss essence lotions were prepared respectively, and then tested according to the following testing method. The test results are shown in Tables 2 and 3.

[0041] Method of use of the anti-hair loss essence of this application: After normal shampooing, the subject takes 3-7mL and applies it to the scalp and hair roots according to the amount of hair or habit, and massages for 5-10 minutes before rinsing; Safety inspection: Microbiological testing, physical and chemical testing, and toxicological testing: all are tested in accordance with the Technical Specifications for Safety of Cosmetics (2015 edition); Human trials: 1. Test Object 60 volunteers aged 20-50 were selected and randomly divided into 12 groups, with 5 people in each group; the volunteers had no obvious head diseases; one group was the control group, which did not use any head care products except normal hair washing; 2. Transepidermal Water Loss (TEWL) Test The transepidermal water loss rate (TEWL) and skin moisture content data were measured by the German CK company's skin moisture loss tester Tewameter TM300 and the scalp moisture loss test probe Tewameter TM Nano; one test point was selected on the volunteer's head, and the position of the test point was recorded using a positioning film, and the TEWL value before using the product of this application was measured, recorded as D0; the TEWL values ​​measured on the 14th and 28th days after continuous use were recorded as D14 and D28 days, respectively, and then the average value of each group was calculated; the more the TEWL value decreased, the better the skin barrier performance.

[0042] 3. Scalp elasticity difference The scheme refers to T / CAB0152-2002 Cosmetic Anti-wrinkle, Firming, Moisturizing, Oil Control, Repairing, Nourishing, Soothing 7-item Efficacy Determination Method; The scalp elasticity was measured using a skin elasticity tester Cutometer dualMPA580 from German CK Company; one test point was selected on the volunteer's head, and the position of the test point was recorded using a positioning film, the scalp elasticity value before using the product of the present application and the scalp elasticity value measured on the 28th day after continuous use were measured, the average value of each group was calculated, and then the scalp elasticity difference was calculated, where a positive number indicates an increase in scalp elasticity, and a negative number indicates a decrease in scalp elasticity.

[0043] 4. Does it significantly reduce hair loss? According to the specific requirements of Chapter 8.6 of the "Technical Specifications for Safety of Cosmetics" (2015 edition) (Appendix 8 of Announcement No. 17 of the State Food and Drug Administration in 2021), the hair loss count is performed after using the product of this application for 12 weeks. If the hair loss count at the 12th week is compared with the initial value, p<0.05, it indicates that hair loss is significantly reduced after 12 weeks of use.

[0044] Table 2 Safety test of Examples 1-8 and Comparative Examples 1-3 It can be seen from Table 2 that the anti-hair loss shampoos prepared in Examples 1-8 of the present application and Comparative Examples 1-3 all comply with the provisions of the "Technical Specification for Safety of Cosmetics" (2015 edition).

[0045] Table 3 Test results of Examples 1-8 and Comparative Examples 1-3 It can be seen from the test data of Examples 1-8 and Comparative Examples 1-3, as well as Table 3, that the use of the anti-hair loss essence prepared by the present application for 28 days can effectively reduce the TEWL of the scalp, which can be reduced by up to 4.59 g / h / m 2 , scalp elasticity can be increased by up to 0.16, and hair loss can be significantly reduced after 12 weeks of use.

[0046] This application is to alleviate the problem of hair loss by repairing hair follicles and soothing the scalp, and by improving the health level of the scalp and hair follicles. Poloxamer is a new type of high molecular non-ionic surfactant, which is a polyoxyethylene polyoxypropylene ether block polymer, commonly used as a pharmaceutical excipient for oral use, and can play the role of emulsification stabilization, solubilization, absorption promotion, sustained release, solid dispersant, etc., non-irritating to the skin and non-hemolytic. It is applied to anti-hair loss essence, and the study found that it has excellent compatibility with the skin, can greatly improve the permeability of the skin, and promote the absorption of nutrients by the scalp, thereby repairing hair follicles, soothing the scalp, greatly improving the health level of the scalp, and playing an anti-hair loss role. The test data of Example 1 and Comparative Example 3 can be verified.

[0047] It can be seen from the test data of Example 1 and Comparative Examples 1-3 that poloxamer needs to be used in conjunction with sodium hyaluronate. The effect of single addition is not ideal. Combined with the test data of Examples 5-6, the addition ratio of poloxamer and sodium hyaluronate is also a very critical influencing factor. Sodium hyaluronate is a physiologically active substance widely present in animals and humans, and is distributed in human skin, synovial fluid, umbilical cord, aqueous humor and vitreous body. It is commonly used in cosmetics and can play a good moisturizing role. It is applied to the anti-hair loss essence and found that it can play a very good moisturizing role on the scalp. It is added together with poloxamer and found that sodium hyaluronate can play the role of penetration and introduction liquid, and poloxamer itself also has good biocompatibility, which can introduce poloxamer into the pores, open the pores, and relax them, thereby promoting the absorption of nutrients. The moisturizing effect of sodium hyaluronate can keep the hair follicles moisturized and prevent nutrients from being lost. The synergistic effect of the two substances greatly improves the technical effect of the anti-hair loss essence.

[0048] Although poloxamer itself has good biocompatibility, its physiological activity is insufficient, so sodium hyaluronate is needed to work synergistically to make up for its physiological activity, which can play a role in penetration and absorption. It can be seen from the test data of Example 1 and Example 2 that the advantage of using polypeptides to penetrate the dermis, increase collagen, and reverse skin aging by reconstruction from the inside to the outside, and modifying polypeptides into the molecular structure of poloxamer, poloxamer can be made to have certain physiological activity, so that it can have a stronger synergistic effect with sodium hyaluronate, and further promote the absorption of nutrients by the scalp. In the case where Chinese medicine extracts do not need to be added in large quantities and in a variety of ways, the improvement of its scalp health level is significant, and the anti-hair loss effect is excellent, and the volunteers of the product of the present application all give good reviews. In conjunction with Example 3-4, the average molecular weight of poloxamer should not be too large. And the effect of polypeptides being palmitoyl pentapeptide-4 is better, considering that it is the molecular structure in palmitoyl tripeptide-1, the conjugation effect with the molecular structure of poloxamer is stronger, and the molecular chain of polypeptides should not give full play to its effect.

[0049] It can be seen from the test data of Example 1 and Examples 7-8 that as the amount of skin penetrant added gradually increases, the effect of improving the scalp shows an upward trend, but after the added amount increases from 0.05kg to 0.1kg, the upward trend of the effect is small. Therefore, considering the comprehensive cost, 0.05kg is the optimal addition amount.

[0050] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

Claims

1. An anti-hair loss essence, characterized in that: The anti-hair loss essence comprises component A, component B, component C, component D and component E, the total weight percentage of the raw materials in each component is 100%, and the weight percentage of each component added is as follows: Component A: 0.4-0.6% thickener, 0.3-0.7% moisturizer, and the solvent is added to 100% of the weight of the anti-hair loss essence, and the solvent is water; Component B: skin protectant (1) 1.5-3.5%, niacinamide 0.3-0.7%, skin protectant (2) 0.08-0.12%; The skin protectant (1) is prepared from the following raw materials in percentage by weight: 3-7% of Polygonum multiflorum root extract, 2-4% of propylene glycol, 0.4-0.8% of 1,2-hexanediol, 0.4-0.7% of phenoxyethanol, 0.04-0.08% of ethylhexylglycerin, and water is added to 100% of the weight of the skin protectant (1); The skin protectant (2) is prepared from the following raw materials in percentage by weight: 10-20% glycerin, 1-4% tea extract, 0.4-0.8% 1,2-hexanediol, 0.3-0.7% phenoxyethanol, 0.04-0.08% ethylhexylglycerin, and water is added to 100% of the weight of the skin protectant (2); Component C: solvent 35-45%, fragrance 0.1-0.3%, tetrahydropiperine 0.03-0.07%, matrine 0.005-0.015%; Component D: anti-hair loss agent 4-6%, preservative 0.3-1.0%; The anti-hair loss agent is prepared from the following raw materials in percentage by weight: 15-21% 1,3-propylene glycol, 15-21% orientalis leaf extract, 0.4-0.8% hydrogenated castor oil, 0.08-0.12% EDTA-disodium, and water is added to 100% of the weight of the anti-hair loss agent; Component E: skin penetrant 0.01-0.1%; the skin penetrant is made from the following raw materials in parts by weight: poloxamer 50-90%, sodium hyaluronate 10-50%.

2. The anti-hair loss essence according to claim 1, characterized in that: The skin permeation agent is prepared from the following raw materials in parts by weight: 70% poloxamer and 30% sodium hyaluronate.

3. The anti-hair loss essence according to claim 1, characterized in that: The poloxamer is a polypeptide-modified poloxamer.

4. The anti-hair loss essence according to claim 3, characterized in that: The preparation method of the polypeptide-modified poloxamer is as follows: S1, reacting the polypeptide with thionyl chloride to obtain a polypeptide acyl chloride hydrochloride intermediate; S2. reacting poloxamer with the polypeptide acyl chloride hydrochloride intermediate to obtain polypeptide-modified poloxamer.

5. The anti-hair loss essence according to claim 4, characterized in that: The polypeptide is palmitoyl pentapeptide-4.

6. The anti-hair loss essence according to claim 1, characterized in that: The average molecular weight of the poloxamer is 8350-11500.

7. The anti-hair loss essence according to claim 1, characterized in that: The preservative is prepared from the following raw materials in parts by weight: 85-95% phenoxyethanol and 5-15% ethylhexylglycerin.

8. A method for preparing the anti-hair loss essence lotion according to any one of claims 1 to 7, characterized in that: It includes the following steps: S1. Weigh the raw materials of component B and component C according to the amount, and premix them to obtain a premixed solution of component B and a premixed solution of component C; S2. Weigh the raw materials of component A, stir and mix, and heat to 75-90°C, keep warm and stir until swollen and transparent; S3, stirring and cooling to 55-65°C, adding the premixed liquid of component B, stirring evenly; then adding the premixed liquid of component C, stirring evenly; S4. Stir and cool to below 45°C, add the raw materials of component D and component E, stir evenly, and obtain the anti-hair loss essence.

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