Dependence-free anti-aging sleep-aiding preparation and preparation method thereof

Abstract

The invention discloses a dependency-free anti-aging sleep-aiding preparation and a preparation method thereof, and relates to the technical field of preparations, the anti-aging sleep-aiding preparation comprises an ellipsoidal shell and an ellipsoidal core wrapped in the ellipsoidal shell, the ellipsoidal core comprises an anti-aging agent layer, a water absorption expansion layer and a sleep-aiding agent layer which are stacked in sequence, the water absorption expansion layer protrudes at the two ends of the ellipsoidal core to form small water diversion columns; small water inlet holes are formed in the two ends of the ellipsoidal shell and are connected with small water diversion columns; a plurality of first release holes and a plurality of second release holes are formed in the circumferential surface of the ellipsoidal shell, the plurality of first release holes lead to the anti-aging agent layer, and the plurality of second release holes lead to the sleep aid layer. Through the special structural design of the ellipsoidal shell and the ellipsoidal core, isolated coexistence of anti-aging and sleep-aiding components and controllable release of the anti-aging and sleep-aiding components are achieved, so that the dual effects of anti-aging and sleep-aiding can be achieved, and it is guaranteed that the drug effect is continuously exerted.

Description

Technical Field

[0001] The present invention relates to the technical field of preparations, and in particular to a non-dependency anti-aging and sleep-aiding preparation and a preparation method thereof. Background Art

[0002] As people's living standards improve and their health awareness increases, how to fight aging and improve sleep quality has become a concern for more and more people.

[0003] Nowadays, more and more people try to fight aging by taking oral anti-aging preparations, and try to improve sleep quality by taking oral sleep aid preparations. However, most of the anti-aging or sleep aid preparations currently on the market have the following problems: single function, unable to achieve the dual effects of anti-aging and sleep aid at the same time; difficult to control the release rate, and short duration of drug effect. Summary of the invention

[0004] The purpose of the present invention is to overcome the shortcomings of the prior art. The present invention provides a non-dependency anti-aging and sleep-aiding preparation and a preparation method thereof. The special structural design of the ellipsoidal shell and the ellipsoidal core realizes the isolated coexistence of anti-aging and sleep-aiding components, and realizes the controlled release of the anti-aging and sleep-aiding components, thereby achieving the dual effects of anti-aging and sleep-aiding, and ensuring the continuous effect of the drug.

[0005] The present invention provides an anti-aging sleep-aiding preparation with no dependence, comprising an ellipsoidal shell and an ellipsoidal core wrapped in the ellipsoidal shell, wherein the ellipsoidal core comprises an anti-aging agent layer, a water-absorbing swelling layer and a sleep-aiding agent layer stacked in sequence, wherein the water-absorbing swelling layer protrudes at both ends of the ellipsoidal core to form water-inducing columns; water inlet holes are provided at both ends of the ellipsoidal shell, and the water inlet holes are connected to the water-inducing columns; a plurality of first release holes and a plurality of second release holes are provided on the circumferential surface of the ellipsoidal shell, wherein the plurality of the first release holes lead to the anti-aging agent layer, and the plurality of the second release holes lead to the sleep-aiding agent layer.

[0006] Specifically, the diameter of any of the water inlet holes is in the range of 0.1 to 0.3 mm, the diameter of any of the first release holes is in the range of 0.5 to 1.0 mm, and the diameter of any of the second release holes is in the range of 0.5 to 1.0 mm.

[0007] Specifically, the number of the first release holes is N, the number of the second release holes is M, and the constraint relationship between N and M is: 1.5N≤M≤3N.

[0008] Specifically, the volume of the main body of the anti-aging and sleep-aiding preparation is A, the volume of the ellipsoidal core is B, and the constraint relationship between A and B is: 2A / 3≤B≤3A / 4.

[0009] Specifically, the volume ratio of the anti-aging agent layer, the water-swellable layer and the sleep-aiding agent layer is in the range of 3-4:1:3-4.

[0010] Specifically, the length of the major axis of the ellipsoidal shell is in the range of 15 to 20 mm, and the length of the minor axis of the ellipsoidal shell is in the range of 6 to 8 mm.

[0011] Specifically, the raw material of the ellipsoidal shell includes one or more of beeswax, synthetic wax, and carnauba wax; The anti-aging ingredients of the anti-aging agent layer include one or more of resveratrol, quercetin, and ergothioneine, and the auxiliary materials of the anti-aging agent layer include compressible starch, sodium carboxymethyl starch, and sodium carboxymethyl cellulose; The raw materials of the water-absorbing and swelling layer include sodium carboxymethyl starch, cross-linked sodium carboxymethyl cellulose and low-substituted hydroxypropyl cellulose; The sleep-aiding ingredients of the sleep-aiding agent layer include one or more of jujube seed saponin, gamma-aminobutyric acid, and theanine, and the auxiliary materials of the sleep-aiding agent layer include compressible starch, sodium carboxymethyl starch, and sodium carboxymethyl cellulose.

[0012] Specifically, the content of the anti-aging component of the anti-aging agent layer is 200-400 mg / grain, and the content of the sleep-aiding component of the sleep-aiding agent layer is 200-400 mg / grain.

[0013] The present invention also provides a method for preparing the non-addictive anti-aging and sleep-aiding preparation, comprising the following steps: S1. Pressing the anti-aging agent raw material to form an anti-aging agent layer, wherein the anti-aging agent layer is a first semi-ellipsoidal structure; S2, pressing the water-swelling raw material on the anti-aging agent layer to form a water-swelling layer, wherein the main body of the water-swelling layer is an elliptical structure, and the two ends of the elliptical structure are protruding to form water-inducing small columns; S3, pressing a sleep aid raw material on the water-swellable layer to form a sleep aid layer, wherein the sleep aid layer is a second semi-ellipsoidal structure, and the first semi-ellipsoidal structure, the ellipsoidal structure and the second semi-ellipsoidal structure constitute an ellipsoidal core; S4, pressing the first shell raw material to form a first semi-ellipsoidal shell; S5, placing the ellipsoidal core in the first semi-ellipsoidal shell, and then pressing the second shell raw material on the ellipsoidal core to form a second semi-ellipsoidal shell, wherein the first semi-ellipsoidal shell and the second semi-ellipsoidal shell constitute an ellipsoidal shell; S6, using a laser to open water inlet holes at both ends of the ellipsoidal shell, wherein the water inlet holes are connected to the water diversion column; S7. Use laser to open a plurality of first release holes and a plurality of second release holes on the circumference of the ellipsoidal shell, wherein a plurality of the first release holes lead to the anti-aging agent layer, and a plurality of the second release holes lead to the sleeping aid agent layer.

[0014] Specifically, after step S7, the method further includes: A light calcium carbonate powder coating layer is formed on the surface of the ellipsoidal shell.

[0015] Compared with the prior art, the present invention has the following beneficial effects: In the non-dependency anti-aging and sleep-aiding preparation of the present invention, the ellipsoidal core contains an anti-aging agent layer and a sleep-aiding agent layer, achieving the dual functions of anti-aging and sleep-aiding; the water-absorbing and swelling layer is located between the anti-aging agent layer and the sleep-aiding agent layer, which can separate the anti-aging agent layer and the sleep-aiding agent layer on the one hand, and control the release rate of the anti-aging ingredients and the sleep-aiding ingredients on the other hand; the design of the water-introducing columns and the water-inlet holes can guide water into the interior of the preparation, promote the expansion of the water-absorbing and swelling layer, thereby controlling the release of the anti-aging ingredients and the sleep-aiding ingredients; the first release hole and the second release hole lead to the anti-aging agent layer and the sleep-aiding agent layer respectively, which can not only guide water into the interior of the preparation, promote the dissolution of the anti-aging agent layer and the sleep-aiding agent layer, but also control the release of the anti-aging ingredients and the sleep-aiding ingredients respectively.

[0016] When the anti-aging and sleep-aiding preparation is taken by a person, water can enter the ellipsoidal shell from the water inlet holes and the release holes, and the anti-aging agent layer and the sleep-aiding agent layer will gradually dissolve, and the water-absorbing and swelling layer will gradually expand; under the expansion and squeezing of the water-absorbing and swelling layer, the dissolved anti-aging agent layer and the sleep-aiding agent layer will gradually be discharged from the corresponding release holes, which is convenient for human body to absorb. The present invention can achieve the isolated coexistence of anti-aging ingredients and sleep-aiding ingredients through the special structural design of the ellipsoidal shell and the ellipsoidal core, and can also achieve the controlled release of anti-aging ingredients and sleep-aiding ingredients, so as to achieve the dual effects of anti-aging and sleep-aiding, and effectively prolong the duration of the drug effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0018] Figure 1 Schematic diagram of the overall structure of the non-addictive anti-aging and sleep-aiding preparation in an embodiment of the present invention; Figure 2 Schematic diagram of the explosion structure of the non-addictive anti-aging and sleep-aiding preparation in an embodiment of the present invention; Figure 3Schematic diagram of the cross-sectional structure of the non-addictive anti-aging and sleep-aiding preparation in an embodiment of the present invention; Figure 4 It is a schematic flow chart of the preparation method of the non-addictive anti-aging and sleep-aiding preparation in an embodiment of the present invention.

[0019] In the attached drawings, 100, ellipsoidal shell; 101, water inlet hole; 110, first semi-ellipsoidal shell; 111, first release hole; 120, second semi-ellipsoidal shell; 121, second release hole; 200, ellipsoidal core; 210, anti-aging agent layer; 220, water absorption and expansion layer; 221, water diversion column; 230, sleep-aid agent layer. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] The present invention provides a non-dependency anti-aging and sleep-aiding preparation. Figure 1 The overall structure diagram of the non-addictive anti-aging and sleep-aiding preparation in the embodiment of the present invention is shown. Figure 2 The exploded structure diagram of the non-addictive anti-aging and sleep-aiding preparation in the embodiment of the present invention is shown. Figure 3 The cross-sectional structure diagram of the non-addictive anti-aging sleep-aiding preparation in an embodiment of the present invention is shown; the anti-aging sleep-aiding preparation comprises an ellipsoidal shell 100 and an ellipsoidal core 200 wrapped in the ellipsoidal shell 100, the ellipsoidal core 200 comprises an anti-aging agent layer 210, a water-absorbing swelling layer 220 and a sleep-aiding agent layer 230 stacked in sequence, the water-absorbing swelling layer 220 protrudes at both ends of the ellipsoidal core 200 to form water-guiding columns 221; water inlet holes 101 are provided at both ends of the ellipsoidal shell 100, and the water inlet holes 101 are connected to the water-guiding columns 221; a plurality of first release holes 111 and a plurality of second release holes 121 are provided on the circumferential surface of the ellipsoidal shell 100, a plurality of the first release holes 111 lead to the anti-aging agent layer 210, and a plurality of the second release holes 121 lead to the sleep-aiding agent layer 230.

[0022] In the non-dependency anti-aging and sleep-aiding preparation of the present invention, the ellipsoidal core 200 comprises an anti-aging agent layer 210 and a sleep-aiding agent layer 230, achieving the dual functions of anti-aging and sleep-aiding; the water-absorbing and swelling layer 220 is located between the anti-aging agent layer 210 and the sleep-aiding agent layer 230, which can separate the anti-aging agent layer 210 and the sleep-aiding agent layer 230 on the one hand, and control the release rate of the anti-aging ingredients and the sleep-aiding ingredients on the other hand; the design of the water-introducing column 221 and the water inlet hole 101 can guide water into the preparation, promote the expansion of the water-absorbing and swelling layer 220, and thus control the release of the anti-aging ingredients and the sleep-aiding ingredients; the first release hole 111 and the second release hole 121 lead to the anti-aging agent layer 210 and the sleep-aiding agent layer 230 respectively, which can not only guide water into the preparation, promote the dissolution of the anti-aging agent layer 210 and the sleep-aiding agent layer 230, but also control the release of the anti-aging ingredients and the sleep-aiding ingredients respectively.

[0023] When the anti-aging and sleep-aiding preparation is taken by a person, water can enter the ellipsoidal shell 100 from the water inlet hole 101 and the release hole, and the anti-aging agent layer 210 and the sleep-aiding agent layer 230 will gradually dissolve, and the water-absorbing and expanding layer 220 will gradually expand; under the expansion and squeezing of the water-absorbing and expanding layer 220, the dissolved anti-aging agent layer 210 and the sleep-aiding agent layer 230 will gradually be discharged from the corresponding release holes, which is convenient for human body to absorb. The present invention can achieve the isolated coexistence of anti-aging ingredients and sleep-aiding ingredients through the special structural design of the ellipsoidal shell 100 and the ellipsoidal core 200, and can also achieve the controlled release of anti-aging ingredients and sleep-aiding ingredients, so as to achieve the dual effects of anti-aging and sleep-aiding, and effectively prolong the duration of the drug effect.

[0024] In addition, compared with the preparations of conventional structures, the two ends of the ellipsoidal structure preparation of the present invention are easier to position, which is conducive to the accurate correspondence between the water inlet hole 101 and the water guide column 221.

[0025] In some specific embodiments, the length of the water diversion column 221 is in the range of 1.0 to 2.0 mm (this is the distance that the water diversion column 221 protrudes away from the ellipsoidal core 200), and the end surface area of ​​the water diversion column 221 is in the range of 1.0 to 2.0 mm. 2 , which is beneficial to cooperate with the water inlet hole 101 to guide water to quickly enter the interior of the anti-aging sleep aid preparation; moreover, the water-introducing column 221 of appropriate size can be used as a transition section, so that the water first diffuses in the water-introducing column 221 and then is transferred to the water-absorbing and expanding layer 220, which is beneficial to promote the uniform diffusion of water into the water-absorbing and expanding layer 220 and improve the expansion uniformity of the water-absorbing and expanding layer 220.

[0026] Optionally, the length of the water diversion column 221 can be 1.0 mm, 1.5 mm, or 2.0 mm; the end surface area of ​​the water diversion column 221 can be 1.0 mm 2 , or 1.4mm2 , or 1.8mm 2 , or 2.0mm 2 Preferably, the length of the water diversion column 221 is 2.0 mm, and the end surface area of ​​the water diversion column 221 is 2.0 mm 2 , the best water diffusion effect can be achieved without affecting the overall size of the ellipsoidal shell 100 and the ellipsoidal core 200.

[0027] In some specific embodiments, the diameter range of any of the water inlet holes 101 is 0.1 to 0.3 mm, which can control the speed and amount of water entering the preparation, and avoid excessive or excessive water entering, which may cause the water absorption and expansion layer 220 to expand too quickly; the diameter range of any of the first release holes 111 is 0.5 to 1.0 mm, and the diameter range of any of the second release holes 121 is 0.5 to 1.0 mm. The diameter range of the first release hole 111 and the second release hole 121 are both set to 0.5 to 1.0 mm, which not only facilitates the entry of water and promotes the slow dissolution of the anti-aging agent layer 210 and the sleep-aid agent layer 230, but also controls the release rate of the anti-aging ingredients and the sleep-aid ingredients, allowing them to be slowly and continuously released, thereby prolonging the duration of the drug effect; moreover, the overall diameter of the release hole is larger than the diameter of the water inlet hole 101, which can promote the release of the expansion pressure of the water absorption and expansion layer 220 toward the release hole.

[0028] Preferably, the diameter range of any of the water inlet holes 101 is 0.15-0.25 mm, and the diameter range of the first release hole 111 and the second release hole 121 are both set to 0.7-0.8 mm, which not only ensures that the anti-aging ingredients and sleep-aiding ingredients can be released continuously and stably, but also avoids poor efficacy or side effects caused by too rapid release of the anti-aging ingredients and sleep-aiding ingredients.

[0029] In some specific embodiments, the number of the first release holes 111 is N, and the number of the second release holes 121 is M, and the constraint relationship between N and M is: 1.5N≤M≤3N; optionally, M=1.5N, or M=2N, or M=3N; the first release holes 111 are used to release anti-aging ingredients, and the second release holes 121 are used to release sleep-aiding ingredients. The number M of the second release holes 121 is 1.5 to 3 times more than the number N of the first release holes 111, which is used to speed up the release of sleep-aiding ingredients so that people can fall asleep faster at night; at the same time, it also avoids the release time of sleep-aiding ingredients being too long and affecting people's mental state during the day. A smaller number of first release holes 111 can slowly release anti-aging ingredients and achieve a long-term anti-aging effect.

[0030] Specifically, the distance between adjacent first release holes 111 is ≥ 2 mm, and the distance between adjacent second release holes 121 is ≥ 2 mm, which is beneficial to the uniform release of anti-aging ingredients and sleep-aiding ingredients on the one hand, and helps to avoid the release holes being too dense to affect the strength of the ellipsoidal shell 100 on the other hand.

[0031] In some specific embodiments, the volume of the main body of the anti-aging sleep-aiding preparation is A, the volume of the ellipsoidal core 200 is B, and the constraint relationship between A and B is: 2A / 3≤B≤3A / 4. By controlling the volume of the ellipsoidal core 200 to be between 2 / 3 and 3 / 4 of the volume of the whole preparation, it is ensured that the anti-aging agent layer 210 and the sleep-aiding agent layer 230 have sufficient content to exert the expected efficacy; a suitable thickness is reserved for the ellipsoidal shell 100 so that it can effectively wrap and protect the internal core structure; moreover, this proportional relationship provides sufficient space for the setting of the water inlet hole 101, the first release hole 111 and the second release hole 121 on the ellipsoidal shell 100, which is conducive to the entry of water and the release of active ingredients of the anti-aging sleep-aiding preparation when in use; in addition, this design also takes into account the overall strength and stability of the anti-aging sleep-aiding preparation, and avoids the ellipsoidal shell 100 being too thin due to the ellipsoidal core 200 being too large, thereby affecting the integrity of the anti-aging sleep-aiding preparation.

[0032] In some specific embodiments, the volume ratio of the anti-aging agent layer 210, the water-absorbing swelling layer 220 and the sleep-aiding agent layer 230 ranges from 3 to 4:1:3 to 4. The volume ratio of the anti-aging agent layer 210 and the sleep-aiding agent layer 230 is the same, both of which are 3 to 4 times that of the water-absorbing swelling layer 220, ensuring the balanced performance of the two functions of anti-aging and sleep-aiding, and avoiding that one function is too prominent and affects the overall effect; at the same time, the larger volume of the anti-aging agent layer 210 and the sleep-aiding agent layer 230 can accommodate a sufficient dose of active ingredients, ensuring the effectiveness of the product. Although the water-absorbing swelling layer 220 is small in size, its role is crucial; the water-absorbing swelling layer 220 is located between the anti-aging agent layer 210 and the sleep-aiding agent layer 230, and the water-absorbing swelling can promote the dissolution and release of the functional layers on both sides. The smaller volume is conducive to the rapid response of the water-absorbing swelling layer 220, and it will not expand excessively and affect the overall structure.

[0033] This volume ratio design also takes into account the overall size of the anti-aging sleep-aiding preparation. Since the anti-aging agent layer 210 and the sleep-aiding agent layer 230 are relatively large in volume, sufficient content of active ingredients can be guaranteed; and the water-absorbing and swelling layer 220 is relatively small in volume, so that the volume of the entire anti-aging sleep-aiding preparation will not be too large, making it easier to take.

[0034] Optionally, the volume ratio of the anti-aging agent layer 210, the water-absorbing and swelling layer 220 and the sleep-inducing agent layer 230 may be 3:1:3, or 3.5:1:3.5, or 4:1:4. Preferably, the volume ratio of the anti-aging agent layer 210, the water-absorbing and swelling layer 220 and the sleep-inducing agent layer 230 is 4:1:4, so that the anti-aging agent layer 210 and the sleep-inducing agent layer 230 each account for about 44.4% of the volume, and the water-absorbing and swelling layer 220 accounts for about 11.1% of the volume. This ratio not only ensures sufficient content of anti-aging ingredients and sleep-inducing ingredients, but also ensures that the water-absorbing and swelling layer 220 can fully play its key role, and the boosting effect of the water-absorbing and swelling layer 220 is the best.

[0035] Furthermore, the thickness of the water-absorbing expansion layer 220 is in the range of 0.8 to 1.0 mm, so that the water-absorbing expansion layer 220 has sufficient strength and is convenient for integrally forming the water-guiding column 221. Optionally, the thickness of the water-absorbing expansion layer 220 can be 0.8 mm, 0.9 mm, or 1.0 mm.

[0036] In some specific embodiments, the length of the major axis of the ellipsoidal shell 100 ranges from 15 to 20 mm, and the length of the minor axis of the ellipsoidal shell 100 ranges from 6 to 8 mm. Specifically, the length of the major axis of the ellipsoidal shell 100 can be adjusted within the range of 15 to 20 mm, for example, specific values ​​such as 15 mm, 17 mm, 19 mm or 20 mm can be selected; the minor axis length can be selected within the range of 6 to 8 mm, such as 6 mm, 7 mm or 8 mm. This size range can accommodate enough anti-aging ingredients and sleep-aiding ingredients to ensure the effectiveness of the preparation; the ellipsoidal structural design and moderate size make the anti-aging sleep-aiding preparation easy to swallow, which improves people's compliance; this size range can ensure the structural strength of the ellipsoidal shell 100 and prevent damage during storage and transportation; the ellipsoidal structure and moderate size are adapted to the structure of the human digestive tract, which is conducive to the transmission and absorption of the anti-aging sleep-aiding preparation in the human body.

[0037] Preferably, the length of the major axis of the ellipsoidal shell 100 is 15 mm, and the length of the minor axis of the ellipsoidal shell 100 is 6 mm, which is suitable for the swallowing ability of most people.

[0038] In some specific embodiments, the raw materials of the ellipsoidal shell 100 include one or more of beeswax, synthetic wax, and carnauba wax. These wax materials have good formability and stability, will not dissolve in the human body, can effectively wrap the ellipsoidal core 200, and control the release of active ingredients through holes. Moreover, these wax materials have different properties and can be selected or combined according to actual needs; for example, beeswax has good biocompatibility and plasticity, synthetic wax can provide more stable performance, and carnauba wax has a higher melting point and hardness; by adjusting the ratio of different waxes, the most suitable shell material can be obtained.

[0039] Specifically, the raw materials of the ellipsoidal shell 100 include beeswax, synthetic wax and carnauba wax, and the mass ratio of the beeswax, the synthetic wax and the carnauba wax is in the range of 5-7:2-4:1-3, and the formed ellipsoidal shell 100 has good hardness, high stability, high softening point and good smoothness. Preferably, the mass ratio of the beeswax, the synthetic wax and the carnauba wax is 5:4:2, the softening point is greater than 50°C, the hardness is good, the stability is high, and the complete ellipsoidal structure can be maintained after being discharged from the human body.

[0040] In some specific embodiments, the anti-aging ingredients of the anti-aging agent layer 210 include one or more of resveratrol, quercetin, and ergothioneine, which have antioxidant and anti-aging effects and will not cause dependence on the human body; the auxiliary materials of the anti-aging agent layer 210 include compressible starch, sodium carboxymethyl starch and sodium carboxymethyl cellulose, which can improve the stability and compressibility of the anti-aging agent layer 210 and adjust the disintegration rate of the anti-aging agent layer 210.

[0041] Specifically, the mass ratio of the anti-aging component of the anti-aging agent layer 210 to the auxiliary material of the anti-aging agent layer 210 is in the range of 15:2 to 3, so that the anti-aging agent layer 210 is easy to shape, has good stability, and has a good disintegration effect. Preferably, the mass ratio of the anti-aging component of the anti-aging agent layer 210 to the auxiliary material of the anti-aging agent layer 210 is 15:2, which has a high anti-aging effect, good stability, and good disintegration effect.

[0042] Among them, in the auxiliary materials of the anti-aging agent layer 210, the mass ratio of the compressible starch, the sodium carboxymethyl starch and the sodium carboxymethyl cellulose is in the range of 10-20:1-6:3-7, which is conducive to ensuring the stability and compressibility of the anti-aging agent layer 210, as well as the disintegration effect of the anti-aging agent layer 210. Preferably, the mass ratio of the compressible starch, the sodium carboxymethyl starch and the sodium carboxymethyl cellulose is 16:3:5, so that the anti-aging agent layer 210 is easy to shape, has high stability after shaping, and has a good disintegration effect in the solution.

[0043] Furthermore, the anti-aging ingredients of the anti-aging agent layer 210 include resveratrol and quercetin, and the mass ratio of the resveratrol to the quercetin ranges from 5:1 to 5. The combined use of resveratrol and quercetin can not only produce a synergistic anti-aging effect, but also enhance the anti-cancer effect and protect cardiovascular health. Preferably, the mass ratio of the resveratrol to the quercetin is 5:3, with strong biological activity and excellent anti-aging effect.

[0044] In some specific embodiments, the raw materials of the water-absorbing and swelling layer 220 include sodium carboxymethyl starch, cross-linked sodium carboxymethyl cellulose and low-substituted hydroxypropyl cellulose. Sodium carboxymethyl starch has the characteristics of rapid water absorption and swelling, cross-linked sodium carboxymethyl cellulose can provide a continuous swelling effect, and low-substituted hydroxypropyl cellulose can maintain stable swelling performance under different pH environments. The combination of the three has stable swelling capacity and strong water absorption and swelling properties, which can effectively promote the release of anti-aging ingredients and sleep-aiding ingredients.

[0045] Specifically, the mass ratio of the sodium carboxymethyl starch, the cross-linked sodium carboxymethyl cellulose and the low-substituted hydroxypropyl cellulose is in the range of 3-5:2-4:2-4, the water absorption is strong, the water is easily transferred, and the overall expansion effect is good. Preferably, the mass ratio of the sodium carboxymethyl starch, the cross-linked sodium carboxymethyl cellulose and the low-substituted hydroxypropyl cellulose is 4:3:3, so that the water can be quickly transferred in the water-absorbing and expanding layer 220, so that the water-absorbing and expanding layer 220 can expand uniformly.

[0046] In some specific embodiments, the sleep-aiding ingredients of the sleep-aiding agent layer 230 include one or more of jujube saponin, γ-aminobutyric acid, and theanine, all of which have the effect of improving sleep quality and will not cause dependence on the human body; the auxiliary materials of the sleep-aiding agent layer 230 include compressible starch, sodium carboxymethyl starch, and sodium carboxymethyl cellulose, which can improve the stability and compressibility of the sleep-aiding agent layer 230 and adjust the disintegration rate of the sleep-aiding agent layer 230.

[0047] Specifically, the mass ratio of the sleep-aiding ingredients of the sleep-aiding agent layer 230 to the auxiliary materials of the sleep-aiding agent layer 230 is in the range of 15:2-3. On the one hand, the sleep-aiding agent layer 230 is easy to form, has good stability, and has a good disintegration effect; on the other hand, the physical properties such as compressibility, stability, and disintegration speed of the sleep-aiding agent layer 230 and the anti-aging agent layer 210 are close, which is convenient for production, processing, and process control. Preferably, the mass ratio of the sleep-aiding ingredients of the sleep-aiding agent layer 230 to the auxiliary materials of the sleep-aiding agent layer 230 is 15:3, so that the physical properties of the sleep-aiding agent layer 230 and the anti-aging agent layer 210 are highly similar.

[0048] Among them, in the auxiliary materials of the sleep aid layer 230, the mass ratio of the compressible starch, the sodium carboxymethyl starch and the sodium carboxymethyl cellulose is in the range of 10-20:1-6:3-7, which is conducive to ensuring the stability and compressibility of the sleep aid layer 230, as well as the disintegration effect of the sleep aid layer 230. Preferably, the mass ratio of the compressible starch, the sodium carboxymethyl starch and the sodium carboxymethyl cellulose is 16:3:5, that is, the sleep aid layer 230 and the anti-aging agent layer 210 use auxiliary materials of the same ingredients, but with different addition amounts, which is convenient for production and processing and process control.

[0049] Furthermore, the sleep-aiding ingredients of the sleep-aiding agent layer 230 include jujube saponin, γ-aminobutyric acid and theanine, and the mass ratio of the jujube saponin, the γ-aminobutyric acid and theanine is in the range of 2-6:1-3:3-7. Jujube saponin has a calming effect, γ-aminobutyric acid can stabilize sleep, and theanine can help relax the body and mind. The three are used in combination in a specific ratio to effectively improve people's sleep quality, and they feel refreshed after waking up. Preferably, the mass ratio of the jujube saponin, the γ-aminobutyric acid and theanine is 6:1:7, which is suitable for most people and has a wide range of effectiveness.

[0050] In some specific embodiments, the content of anti-aging ingredients in the anti-aging agent layer 210 is 200-400 mg / grain, and the content of sleep-aiding ingredients in the sleep-aiding agent layer 230 is 200-400 mg / grain, which can ensure that there are sufficient effective ingredients in the anti-aging and sleep-aiding preparations to exert anti-aging and sleep-aiding effects without causing adverse reactions due to excessive dosage; moreover, this content setting is coordinated with the structural design of the entire anti-aging and sleep-aiding preparations, and by controlling the number and size of release holes, combined with the content setting of anti-aging ingredients and sleep-aiding ingredients, precise regulation of the release rate and release amount of the effective ingredients can be achieved; for example, when the content of the anti-aging ingredient is 300 mg / grain, 10 first release holes 111 with a diameter of 0.8 mm can be set; when the content of the sleep-aiding ingredient is 350 mg / grain, 15 second release holes 121 with a diameter of 0.7 mm can be set.

[0051] The non-dependency anti-aging and sleep-aiding preparation of the present invention, through the multi-layer structure design of the ellipsoidal shell 100, the anti-aging agent layer 210, the water absorption and expansion layer 220 and the sleep-aiding agent layer 230, the mutual coordination of the water inlet hole 101, the water guide column 221, the first release hole 111 and the second release hole 121, and the selection of multiple materials, enables the anti-aging and sleep-aiding preparation to achieve an effective combination of anti-aging and sleep-aiding functions, and achieve controllable release of anti-aging ingredients and sleep-aiding ingredients, thereby achieving the dual effects of anti-aging and sleep-aiding, and effectively prolonging the duration of the drug effect, and will not cause human dependence, thereby improving the safety and effectiveness of the anti-aging and sleep-aiding preparation; at the same time, through the reasonable selection of raw materials and auxiliary materials, the stability and processability of the anti-aging and sleep-aiding preparation are ensured, which is conducive to the production and application of the product.

[0052] The present invention also provides a method for preparing the non-dependency anti-aging and sleep-aiding preparation. Figure 4 The schematic flow chart of the preparation method of the non-addictive anti-aging and sleep-aiding preparation in the embodiment of the present invention is shown, comprising the following steps: S1. Pressing the anti-aging agent raw material to form an anti-aging agent layer, wherein the anti-aging agent layer is a first semi-ellipsoidal structure; Specifically, by using the first filler to fill the anti-aging agent raw material into the first mold, the anti-aging agent raw material can be easily pressed into the anti-aging agent layer 210 with a semi-ellipsoidal structure.

[0053] In some specific embodiments, the anti-aging agent raw material is mixed with a first food coloring to distinguish and identify the formed anti-aging agent layer 210 .

[0054] S2, pressing the water-swelling raw material on the anti-aging agent layer to form a water-swelling layer, wherein the main body of the water-swelling layer is an elliptical structure, and the two ends of the elliptical structure are protruding to form water-inducing small columns; Specifically, the second mold is placed on the first mold, and the water-swelling raw material is filled into the second mold using a second filler, so that the water-swelling raw material can be easily pressed into an elliptical water-swelling layer 220 on the anti-aging agent layer 210, and the water-introducing column 221 can be formed at the same time.

[0055] S3, pressing a sleep aid raw material on the water-swellable layer to form a sleep aid layer, wherein the sleep aid layer is a second semi-ellipsoidal structure, and the first semi-ellipsoidal structure, the ellipsoidal structure and the second semi-ellipsoidal structure constitute an ellipsoidal core; Specifically, the third mold is mounted on the second mold, and the third filler is used to fill the sleep aid raw material into the third mold, so that the sleep aid raw material can be easily pressed into a sleep aid layer 230 with a semi-ellipsoidal structure on the water-absorbing and expanding layer 220 .

[0056] S4, pressing the first shell raw material to form a first semi-ellipsoidal shell; Specifically, the first shell material can be easily pressed into the first semi-ellipsoidal shell 110 by using the fourth filler to fill the first shell material into the fourth mold.

[0057] In some specific embodiments, the first shell material is mixed with a second food coloring agent for distinguishing and identifying the formed first semi-ellipsoidal shell 110 .

[0058] S5, placing the ellipsoidal core in the first semi-ellipsoidal shell, and then pressing the second shell raw material on the ellipsoidal core to form a second semi-ellipsoidal shell, wherein the first semi-ellipsoidal shell and the second semi-ellipsoidal shell constitute an ellipsoidal shell; Specifically, the anti-aging agent layer 210 of the ellipsoidal core 200 is placed downward in the first semi-ellipsoidal shell 110 (that is, the anti-aging agent layer 210 is embedded in the first semi-ellipsoidal shell 110), and then the fifth mold is placed on the fourth mold, and the fifth filler is used to fill the second shell raw material into the fifth mold, so that the second shell raw material can be easily pressed into the second semi-ellipsoidal shell 120 on the ellipsoidal core 200, and the second semi-ellipsoidal shell 120 and the first semi-ellipsoidal shell 110 are connected as a whole.

[0059] The second shell material has the same ingredients as the first shell material except that it does not contain food coloring, so that the first semi-ellipsoidal shell 110 and the second semi-ellipsoidal shell 120 have good connectivity and are stable and reliable after being connected.

[0060] S6, using a laser to open water inlet holes at both ends of the ellipsoidal shell, wherein the water inlet holes are connected to the water diversion column; Specifically, the centers of the two ends of the ellipsoidal shell 100 are first located, and then the ellipsoidal shell 100 is melted through by laser to form the water inlet hole 101 , and the water inlet hole 101 exposes the water guide column 221 .

[0061] Furthermore, laser can be used to melt through the entire water-absorbing expansion layer 220 to form a water diversion channel. The two ends of the water diversion channel are connected to the water inlet holes 101, which helps water to quickly enter the deep part of the water-absorbing expansion layer 220, thereby facilitating the improvement of the expansion uniformity of the water-absorbing expansion layer 220.

[0062] S7. Use laser to open a plurality of first release holes and a plurality of second release holes on the circumference of the ellipsoidal shell, wherein a plurality of the first release holes lead to the anti-aging agent layer, and a plurality of the second release holes lead to the sleeping aid agent layer.

[0063] Specifically, the first semi-ellipsoidal shell 110 of the ellipsoidal shell 100 is first distinguished and identified, and then a plurality of first release holes 111 are opened on the first semi-ellipsoidal shell 110 by laser, and then a plurality of second release holes 121 are opened on the second semi-ellipsoidal shell 120 by laser.

[0064] In some specific embodiments, after step S7, it also includes: wrapping the surface of the ellipsoidal shell 100 to form a light calcium carbonate powder coating layer. The light calcium carbonate powder coating layer can prevent the anti-aging sleep-aiding preparations from sticking together on the one hand, and can react with gastric juice to produce microbubbles on the other hand. When the microbubbles burst, they can destroy the hydrophobicity of the surface of the anti-aging sleep-aiding preparation, which is conducive to the entry of water into the interior of the anti-aging sleep-aiding preparation from the water inlet hole 101, the first release hole 111 and the second release hole 121.

[0065] Specifically, the light calcium carbonate powder coating layer is prepared by the following method: prepare syrup with a concentration of 60wt% to 70wt% and light calcium carbonate powder passed through a 400-mesh sieve; use a coating machine to perform coating operations, sprinkle syrup once, then sprinkle light calcium carbonate powder once, and then hot air dry for 20 to 30 minutes (50 to 55°C), repeat the above operation 6 to 12 times, and wrap the surface of the ellipsoidal shell 100 to form a light calcium carbonate powder coating layer.

[0066] The preparation method of the non-addictive anti-aging and sleep-aiding preparation of the present invention uses a pressing method to sequentially form an anti-aging agent layer 210, a water absorption and expansion layer 220 (including a water-inducing column 221), a sleep-aiding agent layer 230, a first semi-ellipsoidal shell 110, and a second semi-ellipsoidal shell 120 to form the anti-aging and sleep-aiding preparation as a whole; then, a water inlet hole 101, a first release hole 111, and a second release hole 121 are opened on the ellipsoidal shell 100 by laser; finally, a light calcium carbonate powder coating layer is formed on the surface of the ellipsoidal shell 100 by a coating machine. The preparation method of the present invention can accurately control the structure of the anti-aging and sleep-aiding preparation, realize the unique layered structure and hole design of the anti-aging and sleep-aiding preparation, successfully separate the anti-aging and sleep-aiding functions, and realize controlled release through the holes and water absorption and expansion mechanism, so as to achieve the dual effects of anti-aging and sleep-aiding, and effectively prolong the duration of the drug effect.

[0067] The above is a detailed introduction to a non-addictive anti-aging sleep-aiding preparation and a preparation method thereof provided by an embodiment of the present invention. Specific examples are used herein to illustrate the principle and implementation mode of the present invention. The description of the above embodiments is only used to help understand the method of the present invention and its core idea. At the same time, for a person skilled in the art, according to the idea of ​​the present invention, there will be changes in the specific implementation mode and application scope. In summary, the content of this specification should not be understood as limiting the present invention.

Claims

1. A non-addictive anti-aging and sleep-aiding preparation, characterized in that: The anti-aging and sleep-aiding preparation includes an ellipsoidal shell and an ellipsoidal core wrapped in the ellipsoidal shell, the ellipsoidal core includes an anti-aging agent layer, a water-absorbing and swelling layer and a sleep-aiding agent layer stacked in sequence, the water-absorbing and swelling layer protrudes at both ends of the ellipsoidal core to form water-inducing columns; water inlet holes are opened at both ends of the ellipsoidal shell, and the water inlet holes are connected to the water-inducing columns; a plurality of first release holes and a plurality of second release holes are opened on the circumferential surface of the ellipsoidal shell, a plurality of the first release holes lead to the anti-aging agent layer, and a plurality of the second release holes lead to the sleep-aiding agent layer.

2. The non-addictive anti-aging sleep-aiding preparation according to claim 1, characterized in that: The diameter of any of the water inlet holes is in the range of 0.1 to 0.3 mm, the diameter of any of the first release holes is in the range of 0.5 to 1.0 mm, and the diameter of any of the second release holes is in the range of 0.5 to 1.0 mm.

3. The non-addictive anti-aging sleep-aiding preparation according to claim 1, characterized in that: The number of the first release holes is N, the number of the second release holes is M, and the constraint relationship between N and M is: 1.5N≤M≤3N.

4. The non-addictive anti-aging sleep-aiding preparation according to claim 1, characterized in that: The volume of the main body of the anti-aging and sleep-aiding preparation is A, the volume of the ellipsoidal core is B, and the constraint relationship between A and B is: 2A / 3≤B≤3A / 4.

5. The non-addictive anti-aging sleep-aiding preparation according to claim 1, characterized in that: The volume ratio of the anti-aging agent layer, the water-absorbing swelling layer and the sleeping aid agent layer is in the range of 3-4:1:3-4.

6. The non-dependency anti-aging and sleep-aiding preparation according to claim 1, characterized in that: The length of the major axis of the ellipsoidal shell is in the range of 15 to 20 mm, and the length of the minor axis of the ellipsoidal shell is in the range of 6 to 8 mm.

7. The non-addictive anti-aging sleep-aiding preparation according to claim 1, characterized in that: The raw material of the ellipsoidal shell includes one or more of beeswax, synthetic wax, and carnauba wax; The anti-aging ingredients of the anti-aging agent layer include one or more of resveratrol, quercetin, and ergothioneine, and the auxiliary materials of the anti-aging agent layer include compressible starch, sodium carboxymethyl starch, and sodium carboxymethyl cellulose; The raw materials of the water-absorbing and swelling layer include sodium carboxymethyl starch, cross-linked sodium carboxymethyl cellulose and low-substituted hydroxypropyl cellulose; The sleep-aiding ingredients of the sleep-aiding agent layer include one or more of jujube seed saponin, gamma-aminobutyric acid, and theanine, and the auxiliary materials of the sleep-aiding agent layer include compressible starch, sodium carboxymethyl starch, and sodium carboxymethyl cellulose.

8. The non-addictive anti-aging sleep-aiding preparation according to claim 1, characterized in that: The content of the anti-aging component of the anti-aging agent layer is 200-400 mg / grain, and the content of the sleep-aiding component of the sleep-aiding agent layer is 200-400 mg / grain.

9. A method for preparing the non-addictive anti-aging and sleep-aiding preparation according to any one of claims 1 to 8, characterized in that: The following steps are involved: S1. Pressing the anti-aging agent raw material to form an anti-aging agent layer, wherein the anti-aging agent layer is a first semi-ellipsoidal structure; S2, pressing the water-swelling raw material on the anti-aging agent layer to form a water-swelling layer, wherein the main body of the water-swelling layer is an elliptical structure, and the two ends of the elliptical structure are protruding to form water-inducing small columns; S3, pressing a sleep aid raw material on the water-swellable layer to form a sleep aid layer, wherein the sleep aid layer is a second semi-ellipsoidal structure, and the first semi-ellipsoidal structure, the ellipsoidal structure and the second semi-ellipsoidal structure constitute an ellipsoidal core; S4, pressing the first shell raw material to form a first semi-ellipsoidal shell; S5, placing the ellipsoidal core in the first semi-ellipsoidal shell, and then pressing the second shell material on the ellipsoidal core to form a second semi-ellipsoidal shell, wherein the first semi-ellipsoidal shell and the second semi-ellipsoidal shell constitute an ellipsoidal shell; S6, using a laser to open water inlet holes at both ends of the ellipsoidal shell, wherein the water inlet holes are connected to the water diversion column; S7. Use laser to open a plurality of first release holes and a plurality of second release holes on the circumference of the ellipsoidal shell, wherein a plurality of the first release holes lead to the anti-aging agent layer, and a plurality of the second release holes lead to the sleeping aid agent layer.

10. The method for preparing the non-addictive anti-aging and sleep-aiding preparation according to claim 9, characterized in that: After step S7, the method further includes: A light calcium carbonate powder coating layer is formed on the surface of the ellipsoidal shell.

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