Traditional Chinese medicine composition for treating altitude stress and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating altitude stress and a preparation method thereof, and belongs to the field of pharmacy, the traditional Chinese medicine composition is composed of active ingredients and / or pharmaceutically acceptable additives prepared from the following raw materials: 50-70g of rhodiola rosea extract powder, 20-30g of pseudo-ginseng powder, 8-12g of saffron flower powder and 4-6g of cordyceps sinensis powder; the product disclosed by the invention can improve hemoglobin and oxyhemoglobin saturation of a human body, has obvious anti-hypoxia and anti-fatigue effects and the like, and has a wide market application prospect in the aspect of improving altitude stress.

Description

Technical Field

[0001] The invention belongs to the field of pharmacy and relates to a Chinese medicine composition and a preparation method thereof. Background Art

[0002] A large proportion of people entering the plateau from the plains will suffer from altitude sickness, which can be divided into acute altitude sickness and chronic altitude sickness according to the length of time they enter and the time of onset. Acute altitude sickness includes acute mild altitude sickness, high-altitude pulmonary edema and high-altitude cerebral edema; chronic altitude sickness is divided into high-altitude polycythemia, high-altitude depression and high-altitude heart disease. Among them, high-altitude pulmonary edema and high-altitude cerebral edema have a high mortality rate once they occur and are not treated in time. The quality of life of patients with chronic altitude sickness will be seriously reduced. After years of clinical practice, it has been confirmed that some Chinese medicine preparations can significantly reduce the incidence of acute and chronic altitude sickness, delay the progression of the disease and promote physical recovery. In order to give full play to the efficacy of traditional Chinese medicine, relieve the symptoms of hypoxic cor pulmonale, and increase the number of people who travel to the west and the plateau, a scientifically compatible Chinese medicine compound preparation is urgently needed. By adopting reasonable compatibility, the pharmacological activity of Chinese medicine can be fully exerted to relieve the symptoms of various altitude reactions. Summary of the invention

[0003] In view of this, the object of the present invention is to provide a Chinese medicine composition for treating altitude sickness and a preparation method thereof.

[0004] To achieve the above purpose, the technical solution of the present invention is:

[0005] A Chinese medicine composition for treating altitude sickness is composed of active ingredients prepared from the following raw materials or active ingredients prepared from the following raw materials plus pharmaceutically acceptable additives: 50-70 grams of rhodiola rosea extract powder, 20-30 grams of notoginseng powder, 8-12 grams of saffron powder, and 4-6 grams of cordyceps sinensis powder; the rhodiola rosea extract powder is prepared by crushing rhodiola rosea to 150-250 meshes, adding 50-90 V / V% ethanol at a solid-liquid ratio of 1:6-8, soaking or ultrasonic extraction or heating reflux or percolation, filtering, combining the filtrate, and spray drying into powder.

[0006] Furthermore, the Rhodiola rosea extract powder is prepared by crushing the Rhodiola rosea to 200 mesh, adding 70 V / V% ethanol according to a solid-liquid ratio of 1:7, heating and refluxing at 40-60° C. for 8-12 hours, filtering, combining the filtrate, and spray-drying into powder.

[0007] Furthermore, the Panax notoginseng powder is 700-900 mesh, the saffron powder is 700-900 mesh, and the cordyceps powder is 700-900 mesh.

[0008] Furthermore, the weight of each raw material is: 60 grams of rhodiola rosea extract powder, 25 grams of Panax notoginseng powder, 10 grams of saffron powder, 5 grams of cordyceps powder, and the dosage form is capsules, which are made into 250 capsules. The pharmaceutically acceptable additives are starch and talc.

[0009] Furthermore, the weight of each raw material is: 60 grams of rhodiola rosea extract powder, 25 grams of Panax notoginseng powder, 10 grams of saffron powder, 5 grams of cordyceps powder, the dosage form is tablets, and 250 tablets are prepared. The pharmaceutically acceptable additives are starch, sodium carboxymethyl starch and magnesium stearate.

[0010] A method for preparing a Chinese medicine composition for treating altitude sickness, wherein the Chinese medicine composition is composed of active ingredients prepared from the following raw materials and pharmaceutically acceptable additives: 50-70 grams of rhodiola rosea extract powder, 20-30 grams of notoginseng powder, 8-12 grams of crocus powder, and 4-6 grams of cordyceps sinensis powder; the rhodiola rosea extract powder is prepared by crushing rhodiola rosea to 150-250 meshes, adding 50-90 V / V% ethanol at a solid-liquid ratio of 1:6-8, soaking or ultrasonic extraction or heating reflux or percolation, filtering, combining filtrate, and spray drying into powder; and mixing the notoginseng powder, crocus powder, cordyceps sinensis powder, the rhodiola rosea extract powder and the pharmaceutically acceptable additives, drying, and preparing capsules or tablets.

[0011] Furthermore, the Rhodiola rosea extract powder is prepared by crushing Rhodiola rosea to 200 meshes, adding 70 V / V% ethanol according to a solid-liquid ratio of 1:7, heating and refluxing at 40-60° C. for 8-12 hours, filtering, combining the filtrate, and spray-drying into powder.

[0012] Furthermore, the weight of each raw material is: 60 grams of Rhodiola rosea extract powder, 25 grams of Panax notoginseng powder, 10 grams of saffron powder, and 5 grams of Cordyceps sinensis powder, which are made into 250 capsules or 250 tablets.

[0013] In the Chinese medicine composition of the present invention, the effects of each medicine are as follows:

[0014] Rhodiola rosea is the dried root and rhizome of Rhodiola crenulata (Hook.f.&Thomoson) H.Ohba of the Crassulaceae family. It is sweet, bitter and flat, and has the effects of invigorating qi and promoting blood circulation, unblocking meridians and relieving asthma.

[0015] Panax notoginseng is the dried root and rhizome of Panax notoginseng (Burk.) FHChen, a plant of the Araliaceae family. It is sweet, slightly bitter and warm, and has the effects of removing blood stasis and stopping bleeding, promoting blood circulation and relieving pain.

[0016] Saffron is the upper part of the style and stigma of Crocus sativus L., a plant of the genus Crocus in the family Iridaceae. It is sweet and flat, and has the effects of promoting blood circulation, removing blood stasis, relieving depression and relieving knots.

[0017] Cordyceps sinensis is a complex of the fruiting body and corpse of the Cordyceps sinensis (BerK.) Sacc., a fungus of the family Clavicipitaceae, order Hypocreales, that parasitizes on the larvae of insects of the family Bat Moth. It is sweet and neutral, and has the effects of tonifying the kidney and lungs, stopping bleeding and resolving phlegm.

[0018] The effects of the Chinese medicine used in the comparative examples of the present invention are as follows:

[0019] Ginseng is the dried root and rhizome of Panax ginseng CAMey. It is sweet, slightly bitter and slightly warm. It can greatly replenish vital energy, restore the pulse and strengthen the body, nourish the spleen and lungs, promote the production of body fluids and nourish blood, and calm the mind and improve intelligence.

[0020] Safflower is the dried flower of Carthamus tinctorius L., a plant of the Asteraceae family. The flowers are picked in summer when they turn from yellow to red, and dried in the shade or in the sun. It is pungent and warm. It can promote blood circulation and menstruation, dissipate blood stasis and relieve pain.

[0021] Bailing Capsules are capsules made from fermented Cordyceps sinensis powder [Cs-C-Q80, the dry powder of mycelium obtained by deep liquid fermentation of Hirsutella sinensis Liu, Guo, Yu-et Zeng (1989)]. It nourishes the lungs and kidneys and improves the essence and qi.

[0022] Among the drugs used in the present invention, Rhodiola rosea is mainly used to treat qi deficiency and blood stasis, chest pain, heart pain, hemiplegia due to stroke, fatigue and asthma in clinical traditional Chinese medicine, and is also used to prevent acute mild altitude sickness and mild altitude reaction; Panax notoginseng and its compound preparation are used to treat various internal and external trauma bleeding and the resulting inflammation; Saffron is clinically used to treat blood circulation disorders, improve cardiac blood flow, and have a sedative effect; Cordyceps sinensis is clinically used to improve physical weakness symptoms and enhance immunity.

[0023] The beneficial effects of the present invention are as follows: the product of the present invention can not only improve the tolerance of experimental animals to closed hypoxia and swimming exhaustion, but also can improve human hemoglobin and blood oxygen saturation, has obvious anti-hypoxia, anti-fatigue and other effects, and has broad market application prospects in alleviating altitude sickness. DETAILED DESCRIPTION

[0024] Examples 1-3

[0025] Example 1-3 As shown in Table 1, a Chinese medicine composition for treating altitude sickness, the active ingredients are composed of:

[0026] Table 1

[0027] Weight(g) Example 1 Example 2 Example 3 Rhodiola rosea extract powder 60 50 70 Panax notoginseng powder 25 20 30 Saffron Pollen 10 8 12 Cordyceps powder 5 4 6

[0028] The preparation method of the Chinese medicine composition of Examples 1-3 comprises the steps of:

[0029] The Rhodiola rosea extract powder is prepared by crushing Rhodiola rosea into 200 meshes, adding 70 V / V% ethanol according to a solid-liquid ratio of 1:7, heating and reflux at 50°C for 10 hours, filtering, combining the filtrate, and spray-drying into powder; the Chinese medicine composition is prepared by mixing Panax notoginseng powder, saffron powder, cordyceps powder, the Rhodiola rosea extract powder and starch in appropriate amounts according to the amounts in Table 1, granulating and drying, adding appropriate amounts of sodium carboxymethyl starch and magnesium stearate, mixing, and making into 250 tablets.

[0030] Comparative Examples 1-4

[0031] Comparative Examples 1-4 As shown in Table 2, a Chinese medicine composition for treating altitude sickness, wherein the active ingredients are composed of:

[0032] Table 2

[0033] Weight(g) Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Rhodiola rosea extract powder 0 85 60 60 Panax notoginseng powder 60 0 25 25 Saffron Pollen 30 10 15 0 Cordyceps powder 10 5 0 15

[0034] The preparation method of the Chinese medicine composition of Comparative Examples 1-4 is the same as that of Examples 1-3.

[0035] Comparative Example 5

[0036] The difference from Example 1 is that the components of the traditional Chinese medicine composition are changed, the rhodiola rosea extract powder is replaced with 98% salidroside powder, and the other components are the same as those in Example 1. The traditional Chinese medicine composition is prepared by mixing appropriate amounts of notoginseng powder, saffron powder, cordyceps powder, the above-mentioned salidroside powder and starch, granulating and drying, adding appropriate amounts of sodium carboxymethyl starch and magnesium stearate, mixing, making 250 tablets, and film-coating.

[0037] The remaining components and the preparation method of the Chinese medicine composition are the same as those in Example 1.

[0038] Comparative Example 6

[0039] The difference from Example 1 is that the components of the Chinese medicine composition are changed, and the Panax notoginseng powder is replaced by ginseng powder.

[0040] The remaining components and the preparation method of the Chinese medicine composition are the same as those in Example 1.

[0041] Comparative Example 7

[0042] The difference from Example 1 is that the components of the Chinese medicine composition are changed, and saffron powder is replaced by safflower powder.

[0043] The remaining components and the preparation method of the Chinese medicine composition are the same as those in Example 1.

[0044] Comparative Example 8

[0045] The difference from Example 1 is that the components of the traditional Chinese medicine composition are changed, and the cordyceps powder is replaced by Bailing capsule powder.

[0046] The remaining components and the preparation method of the Chinese medicine composition are the same as those in Example 1.

[0047] Comparative Example 9

[0048] A Chinese medicine composition for treating altitude sickness, wherein the active ingredients are composed of 80 grams of rhodiola rosea extract powder, 40 grams of notoginseng powder, 13 grams of saffron powder, and 7 grams of cordyceps powder by weight;

[0049] The preparation method of the above-mentioned Chinese medicine composition is the same as that of Example 1.

[0050] Comparative Example 10

[0051] A Chinese medicine composition for treating altitude sickness, wherein the active ingredients are composed of: 40 grams of rhodiola rosea extract powder, 10 grams of notoginseng powder, 7 grams of saffron powder, and 3 grams of cordyceps powder by weight;

[0052] The preparation method of the above-mentioned Chinese medicine composition is the same as that of Example 1.

[0053] Comparative Example 11

[0054] A Chinese medicine composition for treating altitude sickness, wherein the active ingredients are composed of: 100 grams of Rhodiola rosea extract powder;

[0055] The preparation method of the above-mentioned Chinese medicine composition is the same as that of Example 1.

[0056] Comparative Example 12

[0057] A Chinese medicine composition for treating altitude sickness, wherein the active ingredients are composed of: 100 grams of Panax notoginseng powder;

[0058] The preparation method of the above-mentioned Chinese medicine composition is the same as that of Example 1.

[0059] Comparative Example 13

[0060] A Chinese medicine composition for treating altitude sickness, wherein the active ingredients are as follows: 100 grams of saffron powder;

[0061] The preparation method of the above-mentioned Chinese medicine composition is the same as that of Example 1.

[0062] Comparative Example 14

[0063] A Chinese medicine composition for treating altitude sickness, wherein the active ingredients are as follows: 100 grams of Cordyceps sinensis;

[0064] The preparation method of the above-mentioned Chinese medicine composition is the same as that of Example 1.

[0065] Drug efficacy evaluation test

[0066] The present invention studies the therapeutic effects of each group of Chinese medicine compositions on high-altitude hypotension model mice.

[0067] The tablets of the Chinese medicine compositions of Examples 1-3 and Comparative Examples 1-14 were crushed before use, dispersed with an equal amount of distilled water, shaken well before use, and stored at 4° C. Evaluation The compositions of the Examples and Comparative Examples were evaluated for their tolerance to confined hypoxia and swimming exhaustion in experimental animals.

[0068] Dose selection: According to the active ingredients in the tablets, low (8.4 g / kg·d), medium (16.8 g / kg·d), and high (33.6 g / kg·d) doses are equivalent to 0.5 times, 1 times, and 2 times the human equivalent dose; during the test, Example 1 was administered according to the high, medium, and low dose groups, and the other experimental groups and comparative examples were all administered at a medium dose (16.8 g / kg.d).

[0069] 1 Experimental Materials

[0070] 1.1 Experimental animals

[0071] 220 SPF grade C57BL / 6 mice aged 7-8 weeks, half male and half female, weighing (20±2) g, were provided by Jiangsu Wukong Biotechnology Co., Ltd. Before the experiment, the mice were adaptively raised in a clean animal laboratory for 1 week, with males and females separated, at room temperature of 20-25℃, relative humidity of 40%-60%, natural light, and free access to food and water.

[0072] 1.2 Experimental drugs

[0073] Dazhu Rhodiola rosea capsules, national medicine approval number Z20040023, Jiangsu Kangyuan Pharmaceutical Co., Ltd.

[0074] Bailing Capsules: National Medicine Approval Number Z10910036, Hangzhou Sino-US Huadong Pharmaceutical Co., Ltd.

[0075] 98% Salidroside: CAS NO: 10338-51-9, Xi'an Wanfang Biotechnology Co., Ltd.

[0076] 1.3 Experimental Reagents

[0077] Medical grade soda lime, provided by Zhongyi Intelligent Equipment Co., Ltd.

[0078] 2 Experimental methods

[0079] 2.1 Modeling and grouping and drug administration

[0080] C57BL / 6 mice were randomly divided into 22 groups using a random number table method, with 10 mice in each group, namely, a blank control group, a model control group, a positive control group, a high-dose group of Example 1, a medium-dose group of Example 1, a low-dose group of Example 1, groups 2-3 of Examples, and groups 1-14 of Comparative Examples.

[0081] The dose conversion was performed according to the dose conversion coefficients of different animals in the appendix of the Guiding Principles for Clinical Research of New Chinese Medicines. The positive control group was given 0.26 g / kg·d of Rhodiola rosea capsules (National Medicine Standard Z20040023, Jiangsu Kangyuan Pharmaceutical Co., Ltd.) by gavage, and the experimental groups (high, medium and low doses) were given high (8.4 g / kg·d), medium (16.8 g / kg·d) and low (33.6 g / kg·d) of the composition prepared in Example 1, respectively. The normal control group and the model control group were given an equal volume of physiological saline by gavage, once a day, for 21 consecutive days.

[0082] Starting from the 8th day, 30 minutes after daily gavage, mice in all groups except the normal control group were placed in a low-pressure hypoxia animal experimental chamber for decompression and hypoxia exposure: rising to 3000m at a speed of 10m / s and staying for 5min; rising to 4500m at the same speed and staying for 3min; and then rising to 6000m at a speed of 10m / s. Hypoxia exposure lasted for 48 hours, and mice in the normal control group were raised in a normoxic environment. After hypoxia exposure, relevant indicators were measured together with mice in the blank group.

[0083] 2.2 Detection indicators and methods

[0084] 2.2.1 General status observation

[0085] Observe the mice's diet, drinking water, animal activity status, hair color and other changes before and after entering the warehouse.

[0086] 2.2.2 Survival time under closed hypoxic conditions

[0087] 30 minutes after the last administration, the mice were placed in a 200 ml wide-mouth bottle filled with soda lime and sealed with vaseline to measure the survival time.

[0088] 2.2.3 Weighted swimming time measurement

[0089] After the last administration, a 2g weight was applied to the tail of the mouse. 30 minutes later, the mouse was placed in a water tank with a water depth of 20cm and a water temperature of 20℃. The mouse was considered exhausted if its head was submerged in the water for 10 seconds and still could not float to the surface. The swimming time was measured.

[0090] 2.2.4 Body mass measurement

[0091] The experimental mice were sacrificed and weighed, and then the weights of the thymus (mg) and spleen (g) were removed and measured respectively, and the thymus index and spleen index (the dimensionless ratio of the weight of the two to the body weight) were compared.

[0092] 2.2.5 Statistical analysis

[0093] SPSS 22.0 statistical software was used for analysis, and the experimental data were expressed as "mean ± standard deviation (X ± s)". One-way analysis of variance was used for comparison among multiple groups, and P < 0.05 indicated that the difference was statistically significant.

[0094] 3 Results

[0095] 3.1 Observation of general status of mice in each group

[0096] Before entering the cabin, the animals in each group ate and drank normally, moved normally, and had smooth and shiny fur. After entering the cabin, the animals' activities decreased significantly, showing dullness or lying still, especially in the control model group, where the animals' food and water intake decreased significantly, their fur became messy and dull, they curled up and clump together, and their breathing became significantly faster and deeper. Compared with the model control group, the positive control group, the high, medium, and low dose groups in the experiment had a good diet and drinking water, a good mental state, and increased activities.

[0097] 3.2 Effect of the composition on the survival time and swimming exhaustion time of mice under closed hypoxic conditions

[0098] The present invention uses the survival time and swimming exhaustion time of mice under closed hypoxic conditions to evaluate the anti-fatigue ability of mice. The longer the time, the stronger the anti-fatigue ability of mice. The measurement results of the survival time and swimming exhaustion time of each group of mice under closed hypoxic conditions are shown in Table 3. Compared with the normal control group, the survival time and swimming exhaustion time of mice in the model control group under closed hypoxic conditions are significantly shortened, and the difference is statistically significant (P < 0.05), indicating that the model is successful; compared with the model control group, the survival of mice in the positive drug group, the experimental high, medium and low dose groups under closed hypoxic conditions is significantly prolonged, and the difference is statistically significant (P < 0.05); the experimental group gradually prolongs the survival time under closed hypoxic conditions with the increase of drug concentration, and the survival time of the experimental high, medium and low dose groups under closed hypoxic conditions is better than that of the positive drug group (P < 0.05).

[0099] Table 3 Effects of different Chinese medicine compositions on the survival time of mice under closed hypoxic conditions ( n=10)

[0100]

[0101]

[0102] Note: #Compared with blank control group: P < 0.05; ##Compared with blank control group: P < 0.01;

[0103] *Compared with the model control group: P < 0.05; **Compared with the model control group: P < 0.01;

[0104] △Compared with the high-dose group of Example 1: P < 0.05; △△Compared with the high-dose group of Example 1: P < 0.01;

[0105] ○Compared with the dosage group in Example 1: P < 0.05; ○○Compared with the dosage group in Example 1: P < 0.01;

[0106] ●Compared with the low-dose group of Example 1: P < 0.05; ●●Compared with the low-dose group of Example 1: P < 0.01.

[0107] As can be seen from Table 3, Examples 1-3 use a Chinese medicine compound preparation with different proportions of four components, namely, Rhodiola rosea extract powder, Panax notoginseng powder, saffron powder and Cordyceps sinensis powder, and their effects are better than those of Comparative Examples 1-14, indicating that the Chinese medicine compound preparation of the four components used in the present invention can produce a good synergistic effect in the treatment of high-altitude hypotension model mice.

[0108] 3.3 Effect of the composition on thymus index and spleen index

[0109] The results of the determination of the thymus index and spleen index of each group of mice are shown in Table 4. Compared with the normal control group, the thymus index and spleen index of the mice in the model control group were downregulated; compared with the model control group, the thymus index and spleen index of the mice in the positive administration group, the high dose group and the medium dose group of Example 1 were significantly increased, and the differences were statistically significant (P < 0.05), indicating that the composition can effectively improve the spleen index and thymus index of the experimental animals, suggesting that it plays a role in enhancing immunity.

[0110] Table 4 Effects of different Chinese medicine compositions on thymus index and spleen index ( n=10)

[0111]

[0112]

[0113] Note: Compared with the normal control group: P < 0.05 is indicated by "*", P < 0.01 is indicated by "**";

[0114] Compared with the model control group: P < 0.05 is indicated by "#", P < 0.01 is indicated by "##";

[0115] Compared with the positive drug group: P<0.05 is indicated by “▲”, P<0.01 is indicated by “▲▲”.

[0116] Clinical trials:

[0117] The present invention is being clinically tested in Tibet Qiang'an Hospital Co., Ltd.

[0118] 80 young volunteers were selected and randomly divided into four groups, namely, a medium-dose group, a low-dose group, a blank group, and a positive control group. The preparation of the Chinese medicine composition used in the experiment: Rhodiola rosea extract powder is obtained by crushing Rhodiola rosea to 200 mesh, adding 70V / V% ethanol according to a solid-liquid ratio of 1:7, heating and reflux at 50°C for 10h, filtering, combining the filtrate, and spray-drying into powder; 25g of Panax notoginseng powder, 10g of saffron powder, and 5g of Cordyceps sinensis powder are mixed with 60g of the Rhodiola rosea extract powder prepared above, and appropriate amounts of starch, sodium carboxymethyl starch, and magnesium stearate, granulated and dried, crushed into fine powder, and put into capsules to make 250 capsules. Capsules were prepared according to the specification of 0.4g of effective ingredients, 2 capsules / time, 2 times a day in the low-dose group; 4 capsules / time, 2 times a day in the medium-dose group; 0.4g starch capsules were taken in the blank group; and the positive control group took Dazhu Rhodiola rosea capsules (National Medicine Standard Z20040023, Jiangsu Kangyuan Pharmaceutical Co., Ltd.), 4 capsules / time, 3 times a day. After taking the medicine for 15 days, the hemoglobin reduction value was detected. The results showed that the Chinese medicine composition of the present invention can significantly reduce the hemoglobin value of volunteers after exposure to high altitude hypoxia, and has an anti-hypoxia effect.

[0119] Table 5 Effect of the Chinese medicine composition of the present invention on hemoglobin and blood oxygen saturation of volunteers ( n=10)

[0120]

[0121] Note: Compared with the blank group: P < 0.05 is indicated by "*", P < 0.01 is indicated by "**";

[0122] Compared with the positive control group: P<0.05 is indicated by “#”, P<0.01 is indicated by “##”.

Claims

1. A Chinese medicine composition for treating altitude sickness, characterized in that: The invention is composed of active ingredients prepared from the following raw materials or active ingredients prepared from the following raw materials plus pharmaceutically acceptable additives: 50-70 grams of rhodiola rosea extract powder, 20-30 grams of notoginseng powder, 8-12 grams of saffron powder, and 4-6 grams of cordyceps sinensis powder; the rhodiola rosea extract powder is prepared by crushing rhodiola rosea into 150-250 meshes, adding 50-90V / V% ethanol at a solid-liquid ratio of 1:6-8, soaking or ultrasonic extraction or heating reflux or percolation, filtering, combining the filtrate, and spray drying into powder.

2. The Chinese medicine composition according to claim 1, characterized in that: The Rhodiola rosea extract powder is prepared by crushing Rhodiola rosea into 200 meshes, adding 70 V / V% ethanol according to a solid-liquid ratio of 1:7, heating and refluxing at 40-60° C. for 8-12 hours, filtering, combining the filtrate, and spray-drying into powder.

3. The Chinese medicine composition according to claim 1, characterized in that The notoginseng powder is of 700-900 mesh, the saffron powder is of 700-900 mesh, and the cordyceps powder is of 700-900 mesh.

4. The Chinese medicine composition according to claim 1 or 2, characterized in that: The weight of each raw material is as follows: 60 grams of Rhodiola rosea extract powder, 25 grams of Panax notoginseng powder, 10 grams of saffron powder, and 5 grams of Cordyceps sinensis powder. The dosage form is capsules, and 250 capsules are made.

5. The Chinese medicine composition according to claim 1 or 2, characterized in that: The weight of each raw material is as follows: 60 grams of Rhodiola rosea extract powder, 25 grams of Panax notoginseng powder, 10 grams of saffron powder, and 5 grams of Cordyceps sinensis powder. The dosage form is tablets, and 250 tablets are made.

6. The Chinese medicine composition according to claim 4, characterized in that: The pharmaceutically acceptable additives are starch and talcum powder.

7. The Chinese medicine composition according to claim 5, characterized in that: The pharmaceutically acceptable additives are starch, sodium carboxymethyl starch and magnesium stearate.

8. A method for preparing a Chinese medicine composition for treating altitude sickness, characterized in that: The Chinese medicine composition is composed of active ingredients prepared from the following raw materials and pharmaceutically acceptable additives: 50-70 grams of rhodiola rosea extract powder, 20-30 grams of panax notoginseng powder, 8-12 grams of saffron powder, and 4-6 grams of cordyceps sinensis powder; the rhodiola rosea extract powder is prepared by crushing rhodiola rosea into 150-250 meshes, adding 50-90V / V% ethanol at a solid-liquid ratio of 1:6-8, soaking or ultrasonic extraction or heating reflux or percolation, filtering, combining filtrates, and spray drying into powder; the panax notoginseng powder, saffron powder, cordyceps sinensis powder, the rhodiola rosea extract powder and the pharmaceutically acceptable additives are mixed and dried to prepare capsules or tablets.

9. The method for preparing the Chinese medicine composition according to claim 8, characterized in that: The Rhodiola rosea extract powder is prepared by crushing Rhodiola rosea into 200 meshes, adding 70 V / V% ethanol according to a solid-liquid ratio of 1:7, heating and refluxing at 40-60° C. for 8-12 hours, filtering, combining the filtrate, and spray-drying into powder.

10. The method for preparing the Chinese medicine composition according to claim 8 or 9, characterized in that: The weight of each raw material is as follows: 60 grams of Rhodiola rosea extract powder, 25 grams of Panax notoginseng powder, 10 grams of saffron powder, and 5 grams of Cordyceps sinensis powder, which can be made into 250 capsules or 250 tablets.

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