Preparation method of probiotic enteric soft capsule

Abstract

The invention discloses a preparation method of probiotic enteric soft capsules, and belongs to the technical field of health care products. The probiotic enteric soft capsule is prepared by the following steps: respectively inputting a probiotic content and a capsule shell material into a capsule machine, pelleting, cleaning, polishing, shaping and drying. Wherein the probiotic contents comprise probiotic powder, fructo-oligosaccharide, a suspending aid, an antioxidant and the balance of a plant oily solvent; the capsule skin material comprises gel, resistant starch, chitosan, sodium alginate, a flavoring agent, a plasticizer and the balance of sterile water; the probiotic powder is prepared from lactobacillus plantarum, lactobacillus acidophilus and lactobacillus rhamnosus; the probiotic enteric soft capsule prepared by the invention has good storage stability, is safe and non-toxic in components, meets the food safety standard, and can be taken daily as a health-care product.

Description

Technical Field

[0001] The invention relates to the technical field of health care products, in particular to a method for preparing probiotic enteric-coated soft capsules. Background Art

[0002] As active microorganisms that are beneficial to the human body when consumed in moderation, probiotics can improve the balance of the human microecology, promote nutrient absorption, and maintain intestinal health. The composition of the human intestinal flora has regional and individual differences, and is affected by the genetic information of the host. Inevitably, the human intestinal flora will also undergo complex changes due to the external environment, such as dietary structure, exercise habits, sleep quality, negative emotions, etc. In a healthy state, the intestinal flora has good recovery ability from external influences, but once the flora is unbalanced, it will affect metabolic health and lead to the occurrence of certain diseases. Generally speaking, intestinal flora disorders can be slowly improved by adjusting diet and maintaining good living habits, but for emergencies, it is necessary to effectively regulate the intestinal flora by taking probiotic drugs;

[0003] In daily life, as people pay more and more attention to their health, various health foods emerge in an endless stream, among which probiotic products are particularly favored by consumers. Probiotics are mainly delivered to the human body orally, and various products include capsules, powders, oral liquids, tablets, etc., providing consumers with a variety of choices. Probiotic products must be non-toxic and harmless, withstand the dissolution of gastric acid, reach the intestines smoothly, and have a high survival rate of probiotics, so as to exert their efficacy; therefore, it is of great significance to develop a non-toxic, harmless and stable probiotic enteric-coated soft capsule. Summary of the invention

[0004] The object of the present invention is to provide a method for preparing probiotic enteric-coated soft capsules to solve the problems raised in the above-mentioned background technology.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0006] A method for preparing probiotic enteric soft capsules comprises the following steps: respectively inputting probiotic contents and capsule skin materials into a capsule machine for pill pressing, wherein the capsule machine spray body temperature is 30-40° C., the probiotic contents temperature is 30-40° C., and the capsule skin material temperature is 50-60° C. The soft capsules are obtained, and then air-blasted and shaped and dried at a temperature of 30-35° C. and an air relative humidity of 20% for 3-4 hours, and then washed and polished with 95% ethanol, and then left to dry for 16-18 hours to obtain probiotic enteric soft capsules.

[0007] The probiotic content comprises: by mass percentage, 8-10% probiotic powder, 4-5% oligofructose, 2-5% suspending agent, 2-5% antioxidant, and the balance is plant oil solvent.

[0008] The probiotic powder is one or more combination powders of Lactobacillus lactis, Lactobacillus acidophilus, Bifidobacterium longum, Lactobacillus rhamnosus, and Lactobacillus plantarum; further configured as a combination powder of Lactobacillus plantarum, Lactobacillus acidophilus, and Lactobacillus rhamnosus, with a mass ratio of 1:1:1.

[0009] The suspending agent is one or more combinations of beeswax, sodium alginate and hydroxymethyl cellulose; and is further configured as beeswax.

[0010] The antioxidant is linseed oil.

[0011] The vegetable oil solvent is one or more combinations of soybean oil, peanut oil and rice bran oil; and is further configured to be rice bran oil.

[0012] The preparation method of probiotic content comprises the following steps: taking probiotic powder and suspending agent through a 60-100 mesh sieve for standby use, adding the suspending agent into a plant oil solvent, stirring evenly at 65-85° C., cooling to 25-30° C., adding probiotic powder, oligofructose and antioxidant, stirring evenly, and obtaining probiotic content.

[0013] The capsule material comprises, by mass percentage, 10-20% of gelling agent, 20-30% of resistant starch, 2-3% of chitosan, 3-5% of sodium alginate, 1-2% of flavoring agent, 3-4% of plasticizer, and the balance is sterile water.

[0014] The gelling agent is prepared by mixing xanthan gum and konjac gum, and the mass ratio of xanthan gum to konjac gum is 1-2:1.

[0015] The resistant starch is propionylated starch. The preparation steps of the propionylated starch include: mixing potato starch with propionic anhydride, stirring with a magnetic force, adding p-toluenesulfonic acid, reacting at 80-100° C. for 3-4 hours, cooling to 25-28° C., washing, drying, crushing and sieving to obtain the propionylated starch.

[0016] The flavoring agent is one or more combinations of saccharin sodium, sucrose, stevioside, and mogroside; and is further configured as stevioside.

[0017] The plasticizer is one or more combinations of glycerol, sorbitol, and maltitol; it is further configured as a combination of glycerol and sorbitol, and the mass ratio of glycerol to sorbitol is 3 to 4:1.

[0018] The preparation method of capsule skin material comprises the following steps: placing chitosan, sodium alginate and gelling agent in sterile water, stirring and dissolving at 80 DEG C, adding resistant starch, plasticizer and flavoring agent, heating in a water bath at 50-60 DEG C, and stirring evenly by magnetic force to obtain capsule skin material.

[0019] Compared with the prior art, the present invention has the following beneficial effects: the present invention prepares probiotic enteric soft capsules, and different types of probiotic powders selected and added to the probiotic content can be used to produce health food, and human intake can effectively regulate the competitive colonization sites between beneficial bacteria and harmful bacteria in the intestine, compete for nutrients, and thus inhibit the reproduction of harmful bacteria in the intestine; oligofructose is added as a prebiotic component to improve the survival rate of probiotics in the intestine; auxiliary agents including suspending agents and antioxidants are added to the content to improve the stability and survival rate of bacterial powder in rice bran oil, thereby improving the capsule. The capsule skin material includes a combination of xanthan gum and konjac gum as a gelling agent, which is safer than the gelatin material used in conventional capsule skin materials, and can achieve the effect of gelatin under a reasonable ratio; the capsule skin material uses propionylated starch as the main material, and sodium alginate is added to enable the capsule to resist digestion in gastric juice, achieve a controlled release effect, and exert its effect in the intestine; flavoring agents are added to improve the taste of the capsule and are not easy to cause oral aversion; the plasticizer is a compound combination of glycerol and sorbitol to improve the processability of the capsule skin material. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] In the experiment, the probiotic powder was a combination of Lactobacillus plantarum, Lactobacillus acidophilus, and Lactobacillus rhamnosus, with a mass ratio of 1:1:1, including 10 billion cfu / g of Lactobacillus plantarum, 10 billion cfu / g of Lactobacillus acidophilus, 10 billion cfu / g of Lactobacillus rhamnosus, and oligofructose, all purchased from Xi'an Jingmei Biotechnology Co., Ltd.

[0022] Embodiment 1: This embodiment provides a method for preparing probiotic enteric-coated soft capsules, and the specific steps are as follows:

[0023] A preparation method of probiotic enteric soft capsules, comprising the following steps: respectively inputting probiotic contents and capsule skin materials into a capsule machine for pill pressing, wherein the capsule machine spray body temperature is 35°C, the probiotic contents temperature is 35°C, and the capsule skin material temperature is 60°C. The soft capsules are obtained, and then air-blasted and dried at a temperature of 30°C and an air relative humidity of 20% for 4 hours, and then washed and polished with 95% ethanol, and then left to dry for 16 hours to obtain probiotic enteric soft capsules.

[0024] The composition of the probiotic content includes: by mass percentage, 8% probiotic powder, 5% oligofructose, 3% beeswax, 3% linseed oil, and the balance is rice bran oil.

[0025] The preparation method of probiotic content comprises the following steps: taking probiotic powder and beeswax and passing them through a 100-mesh sieve for standby use, adding beeswax into a rice bran oil solvent, stirring evenly at 80°C, cooling to 25°C, adding probiotic powder, oligofructose and linseed oil, stirring evenly, and obtaining probiotic content.

[0026] The capsule shell material comprises, by mass percentage, 12% of gelling agent, 25% of resistant starch, 2% of chitosan, 4% of sodium alginate, 2% of stevioside, 3% of plasticizer, and the balance is sterile water.

[0027] The preparation method of capsule skin material comprises the following steps: placing chitosan, sodium alginate and gelling agent in sterile water, stirring and dissolving at 80°C, adding resistant starch, plasticizer and stevioside, heating at 50°C in a water bath, and stirring evenly with magnetic force to obtain capsule skin material.

[0028] The gel is prepared by mixing xanthan gum and konjac gum in a mass ratio of 1.5:1.

[0029] The resistant starch is propionylated starch. The preparation steps of the propionylated starch include: mixing potato starch with propionic anhydride, magnetically stirring, adding p-toluenesulfonic acid, reacting at 80°C for 4 hours, cooling to 25°C, washing and drying, crushing and sieving to obtain the propionylated starch.

[0030] The plasticizer is a composition of glycerol and sorbitol, with a mass ratio of 3:1.

[0031] Embodiment 2: This embodiment provides a method for preparing probiotic enteric-coated soft capsules, and the specific steps are as follows:

[0032] A preparation method of probiotic enteric soft capsules, comprising the following steps: respectively inputting probiotic contents and capsule skin materials into a capsule machine for pill pressing, wherein the capsule machine spray body temperature is 35°C, the probiotic contents temperature is 40°C, and the capsule skin material temperature is 60°C. The soft capsules are obtained, and then air-blasted and dried at a temperature of 30°C and an air relative humidity of 20% for 4 hours, and then washed and polished with 95% ethanol, and then left to dry for 16 hours to obtain probiotic enteric soft capsules.

[0033] The composition of the probiotic content includes: by mass percentage, 8% probiotic powder, 5% oligofructose, 4% beeswax, 4% linseed oil, and the balance is rice bran oil.

[0034] The preparation of probiotic content comprises the following steps: taking probiotic powder and beeswax through a 100-mesh sieve for standby use, adding beeswax into a rice bran oil solvent, stirring evenly at 80° C., cooling to 25° C., adding probiotic powder, oligofructose and linseed oil, stirring evenly, and obtaining probiotic content.

[0035] The capsule shell material comprises: by mass percentage, 15% of gelling agent, 28% of resistant starch, 3% of chitosan, 5% of sodium alginate, 1% of stevioside, 3% of plasticizer, and the balance is sterile water.

[0036] The preparation method of capsule skin material comprises the following steps: placing chitosan, sodium alginate and gelling agent in sterile water, stirring and dissolving at 80°C, adding resistant starch, plasticizer and stevioside, heating at 50°C in a water bath, and stirring evenly with magnetic force to obtain capsule skin material.

[0037] The gel is prepared by mixing xanthan gum and konjac gum in a mass ratio of 2:1.

[0038] The resistant starch is propionylated starch. The preparation of propionylated starch includes: mixing potato starch with propionic anhydride, magnetically stirring, adding p-toluenesulfonic acid, reacting at 100° C. for 4 hours, cooling to 25° C., washing, drying, crushing and sieving to obtain propionylated starch.

[0039] The plasticizer is a composition of glycerol and sorbitol, with a mass ratio of 4:1.

[0040] Embodiment 3: This embodiment provides a method for preparing probiotic enteric-coated soft capsules, and the specific steps are as follows:

[0041] A method for preparing probiotic enteric soft capsules comprises the following steps: respectively inputting probiotic contents and capsule skin materials into a capsule machine for pill pressing, wherein the capsule machine spray body temperature is 35° C., the probiotic contents temperature is 30° C., and the capsule skin material temperature is 60° C. The soft capsules are obtained, and then air-blasted and dried at a temperature of 30° C. and an air relative humidity of 20% for 4 hours, and then washed and polished with 95% ethanol, and then left to dry for 16 hours to obtain probiotic enteric soft capsules.

[0042] The composition of the probiotic content includes: by mass percentage, 8% probiotic powder, 5% oligofructose, 3% beeswax, 4% linseed oil, and the balance is rice bran oil.

[0043] The preparation of probiotic content comprises the following steps: taking probiotic powder and beeswax through a 100-mesh sieve for standby use, adding beeswax into a rice bran oil solvent, stirring evenly at 80° C., cooling to 25° C., adding probiotic powder, oligofructose and linseed oil, stirring evenly, and obtaining probiotic content.

[0044] The capsule shell material comprises, by mass percentage, 15% of gelling agent, 25% of resistant starch, 3% of chitosan, 5% of sodium alginate, 2% of stevioside, 4% of plasticizer, and the balance is sterile water.

[0045] The preparation method of capsule skin material comprises the following steps: placing chitosan, sodium alginate and gelling agent in sterile water, stirring and dissolving at 80°C, adding resistant starch, plasticizer and stevioside, heating at 50°C in a water bath, and stirring evenly with magnetic force to obtain capsule skin material.

[0046] The gel is prepared by mixing xanthan gum and konjac gum in a mass ratio of 1.5:1.

[0047] The resistant starch is propionylated starch. The preparation of propionylated starch includes: mixing potato starch with propionic anhydride, magnetically stirring, adding p-toluenesulfonic acid, reacting at 80°C for 4 hours, cooling to 25°C, washing, drying, crushing and sieving to obtain propionylated starch.

[0048] The plasticizer is a composition of glycerol and sorbitol, with a mass ratio of 4:1.

[0049] Comparative Example 1: Comparative Example 1 is a control experiment of Example 3, except that oligofructose is not added to Example 3. The specific steps are as follows:

[0050] A method for preparing probiotic enteric soft capsules comprises the following steps: respectively inputting probiotic contents and capsule skin materials into a capsule machine for pill pressing, wherein the capsule machine spray body temperature is 35° C., the probiotic contents temperature is 30° C., and the capsule skin material temperature is 60° C. The soft capsules are obtained, and then air-blasted and dried at a temperature of 30° C. and an air relative humidity of 20% for 4 hours, and then washed and polished with 95% ethanol, and then left to dry for 16 hours to obtain probiotic enteric soft capsules.

[0051] The composition of the probiotic content includes: by mass percentage, 8% of probiotic powder, 3% of beeswax, 4% of linseed oil, and the balance of rice bran oil.

[0052] The preparation of probiotic content comprises the following steps: taking probiotic powder and beeswax through a 100-mesh sieve for standby use, adding beeswax into a rice bran oil solvent, stirring evenly at 80° C., cooling to 25° C., adding probiotic powder and linseed oil, stirring evenly, and obtaining probiotic content.

[0053] The capsule shell material comprises, by mass percentage, 15% of gelling agent, 25% of resistant starch, 3% of chitosan, 5% of sodium alginate, 2% of stevioside, 4% of plasticizer, and the balance is sterile water.

[0054] The preparation method of capsule skin material comprises the following steps: placing chitosan, sodium alginate and gelling agent in sterile water, stirring and dissolving at 80°C, adding resistant starch, plasticizer and stevioside, heating at 50°C in a water bath, and stirring evenly with magnetic force to obtain capsule skin material.

[0055] The gel is prepared by mixing xanthan gum and konjac gum in a mass ratio of 1.5:1.

[0056] The resistant starch is propionylated starch. The preparation of propionylated starch includes: mixing potato starch with propionic anhydride, magnetically stirring, adding p-toluenesulfonic acid, reacting at 80°C for 4 hours, cooling to 25°C, washing, drying, crushing and sieving to obtain propionylated starch.

[0057] The composition of plasticizers glycerol and sorbitol has a mass ratio of 4:1.

[0058] Comparative Example 2: Comparative Example 2 is a control experiment of Example 3, in which the resistant starch of Example 3 is replaced with unpropionylated potato starch, and the specific steps are as follows:

[0059] A method for preparing probiotic enteric soft capsules comprises the following steps: respectively inputting probiotic contents and capsule skin materials into a capsule machine for pill pressing, wherein the capsule machine spray body temperature is 35° C., the probiotic contents temperature is 30° C., and the capsule skin material temperature is 60° C. The soft capsules are obtained, and then air-blasted and dried at a temperature of 30° C. and an air relative humidity of 20% for 4 hours, and then washed and polished with 95% ethanol, and then left to dry for 16 hours to obtain probiotic enteric soft capsules.

[0060] The composition of the probiotic content includes: by mass percentage, 8% probiotic powder, 5% oligofructose, 3% beeswax, 4% linseed oil, and the balance is rice bran oil.

[0061] The preparation of probiotic content comprises the following steps: taking probiotic powder and beeswax through a 100-mesh sieve for standby use, adding beeswax into a rice bran oil solvent, stirring evenly at 80° C., cooling to 25° C., adding probiotic powder, oligofructose and linseed oil, stirring evenly, and obtaining probiotic content.

[0062] The capsule skin material comprises: by mass percentage, 15% of gelling agent, 25% of potato starch, 3% of chitosan, 5% of sodium alginate, 2% of stevioside, 4% of plasticizer, and the balance is sterile water.

[0063] The preparation method of capsule skin material comprises the following steps: placing chitosan, sodium alginate and gelling agent in sterile water, stirring and dissolving at 80°C, adding potato starch, plasticizer and stevioside, heating at 50°C in a water bath, and stirring evenly with a magnetic force to obtain the capsule skin material.

[0064] The gel is prepared by mixing xanthan gum and konjac gum in a mass ratio of 1.5:1.

[0065] The composition of plasticizers glycerol and sorbitol has a mass ratio of 4:1.

[0066] Comparative Example 3: Comparative Example 3 is a control experiment of Example 3, except that sorbitol is not added to the plasticizer of Example 3. The specific steps are as follows:

[0067] A method for preparing probiotic enteric soft capsules comprises the following steps: respectively inputting probiotic contents and capsule skin materials into a capsule machine for pill pressing, wherein the capsule machine spray body temperature is 35° C., the probiotic contents temperature is 30° C., and the capsule skin material temperature is 60° C. The soft capsules are obtained, and then air-blasted and dried at a temperature of 30° C. and an air relative humidity of 20% for 4 hours, and then washed and polished with 95% ethanol, and then left to dry for 16 hours to obtain probiotic enteric soft capsules.

[0068] The composition of the probiotic content includes: by mass percentage, 8% probiotic powder, 5% oligofructose, 3% beeswax, 4% linseed oil, and the balance is rice bran oil.

[0069] The preparation of probiotic content comprises the following steps: taking probiotic powder and beeswax through a 100-mesh sieve for standby use, adding beeswax into a rice bran oil solvent, stirring evenly at 80° C., cooling to 25° C., adding probiotic powder, oligofructose and linseed oil, stirring evenly, and obtaining probiotic content.

[0070] The capsule shell material comprises, by mass percentage, 15% of gelling agent, 25% of resistant starch, 3% of chitosan, 5% of sodium alginate, 2% of stevioside, 4% of glycerol, and the balance is sterile water.

[0071] The preparation method of capsule skin material comprises the following steps: placing chitosan, sodium alginate and gelling agent in sterile water, stirring and dissolving at 80°C, adding resistant starch, glycerol and stevioside, heating at 50°C in a water bath, and stirring evenly with magnetic force to obtain capsule skin material.

[0072] The gel is prepared by mixing xanthan gum and konjac gum in a mass ratio of 1.5:1.

[0073] The resistant starch is propionylated starch. The preparation of propionylated starch includes: mixing potato starch with propionic anhydride, magnetically stirring, adding p-toluenesulfonic acid, reacting at 80°C for 4 hours, cooling to 25°C, washing, drying, crushing and sieving to obtain propionylated starch.

[0074] Detection test:

[0075] 1. Take the soft capsules prepared in Examples 1-3 and Comparative Examples 1-3, randomly select 10 capsules from each group of examples, a total of 60 capsules, observe and test the capsule properties according to GB 16740 General Standard for Health Foods, and record the data.

[0076]

[0077] 2. Enteric solubility test: in vitro digestion simulation was performed, 10 capsules without damage on the surface were randomly selected from each group of examples and comparative examples, placed in artificial gastric juice-hydrochloric acid solution, treated for 2 hours, taken out to check whether there were cracks or disintegration, counted and recorded; then the capsules without cracks or disintegration were selected, washed with clean water, placed in artificial intestinal juice, which was phosphate buffer, and the average disintegration time was calculated and recorded.

[0078] The preparation method of artificial gastric juice-hydrochloric acid solution is as follows: 16.4 ml of dilute hydrochloric acid and 10 g of pepsin are measured, 800 ml of water are added, mixed, and the volume is fixed to 1000 ml.

[0079] The preparation method of artificial intestinal fluid is as follows: weigh 6.8g of potassium dihydrogen phosphate, add 500ml of water to dissolve it, add 0.1mol / L sodium hydroxide to adjust the pH to 6.8, take 10g of pancreatic enzyme, add water to dissolve it, mix it with the above potassium dihydrogen phosphate solution, and dilute it to 1000ml with water to obtain the artificial intestinal fluid;

[0080] project Artificial gastric juice Artificial intestinal fluid Example 1 No cracks, no disintegration 21.4min Example 2 No cracks, no disintegration 17.3min Example 3 No cracks, no disintegration 12.5min Comparative Example 1 No cracks, no disintegration 14.4min Comparative Example 2 3 cracks, 2 disintegrated 38.4min Comparative Example 3 1 crack, no disintegration 27.8min

[0081] 3. Storage stability test: The total number of viable probiotics in the capsules prepared in Examples 1-3 and Comparative Examples 1-3 was counted, and the capsules were stored in a dark place at 4° C. for 90 days. The total number of viable probiotics was counted, and the survival rate of the probiotics was calculated and recorded.

[0082] project Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Survival rate 92.7％ 95.4％ 98.2％ 89.5％ 97.1％ 97.4％

[0083] Through the data obtained from the test of Examples 1-3 and Comparative Examples 1-3, the capsules prepared in Example 3 are superior to the other examples in the enteric solubility test and the storage stability test, and have better efficacy; Comparative Example 1 does not add oligofructose, and after 90 days of storage, the survival rate of the probiotics is significantly lower than that of the other examples and comparative examples; Comparative Example 2 replaces the propionylated starch with unmodified potato starch, which has a great effect on the dissolution of the capsule skin in the gastrointestinal tract; Comparative Example 3 adjusts the plasticizer to full glycerol, which has a slight effect on the dissolution of the soft capsule in the gastrointestinal tract.

[0084] Conclusion: The present invention discloses a method for preparing probiotic enteric-coated soft capsules. The scheme design is reasonable, the parameters of each step are appropriate, the prepared soft capsules have good processability, meet the characteristics of enteric-coated capsules, and have good storage stability.

[0085] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A method for preparing probiotic enteric-coated soft capsules, characterized in that: The probiotic contents and capsule skin material are respectively input into the capsule machine for pelleting to obtain soft capsules, which are then shaped and dried, cleaned and polished with 95% ethanol, and left to dry for 16 to 18 hours to obtain probiotic enteric-coated soft capsules.

2. The method for preparing a probiotic enteric-coated soft capsule according to claim 1, characterized in that: The probiotic content comprises: by mass percentage, 8-10% of probiotic powder, 4-5% of oligofructose, 2-5% of suspending agent, 2-5% of antioxidant, and the balance is plant oil solvent.

3. The method for preparing a probiotic enteric-coated soft capsule according to claim 2, characterized in that: The probiotic powder is one or more combination powders of Lactobacillus lactis, Lactobacillus acidophilus, Bifidobacterium longum, Lactobacillus rhamnosus and Lactobacillus plantarum; the suspending agent is one or more combination of beeswax, sodium alginate and hydroxymethyl cellulose; the antioxidant is linseed oil; and the vegetable oil solvent is one or more combination of soybean oil, peanut oil and rice bran oil.

4. The method for preparing a probiotic enteric-coated soft capsule according to claim 2, characterized in that: The preparation method of probiotic content comprises the following steps: taking probiotic powder and suspending agent through a 60-100 mesh sieve for standby use, adding the suspending agent into a plant oil solvent, stirring evenly at 65-85° C., cooling to 25-30° C., adding probiotic powder, oligofructose and antioxidant, stirring evenly, and obtaining probiotic content.

5. The method for preparing a probiotic enteric-coated soft capsule according to claim 1, characterized in that: The capsule material comprises, by mass percentage, 10-20% of gelling agent, 20-30% of resistant starch, 2-3% of chitosan, 3-5% of sodium alginate, 1-2% of flavoring agent, 3-4% of plasticizer, and the balance is sterile water.

6. The method for preparing a probiotic enteric-coated soft capsule according to claim 5, characterized in that: The gelling agent is prepared by mixing xanthan gum and konjac gum, and the mass ratio of xanthan gum to konjac gum is 1-2:1; the resistant starch is propionylated starch, and the preparation steps of the propionylated starch include: mixing potato starch and propionic anhydride, magnetic stirring, adding p-toluenesulfonic acid, reacting at 80-100 DEG C for 3-4 hours, cooling to 25-28 DEG C, washing, drying, crushing and sieving to obtain the propionylated starch.

7. The method for preparing a probiotic enteric-coated soft capsule according to claim 5, characterized in that: The flavoring agent is one or more combinations of saccharin sodium, sucrose, stevioside, and mogroside; the plasticizer is one or more combinations of glycerol, sorbitol, and maltitol.

8. The method for preparing a probiotic enteric-coated soft capsule according to claim 5, characterized in that: The preparation method of capsule skin material comprises the following steps: placing chitosan, sodium alginate and gelling agent in sterile water, stirring and dissolving at 80 DEG C, adding resistant starch, plasticizer and flavoring agent, heating in a water bath at 50-60 DEG C, and stirring evenly by magnetic force to obtain capsule skin material.

9. The method for preparing a probiotic enteric-coated soft capsule according to claim 1, characterized in that: During the pill pressing process, the capsule machine spray body temperature is 30-40°C, the content temperature is 30-40°C, and the capsule skin material temperature is 50-60°C.

10. The method for preparing a probiotic enteric-coated soft capsule according to claim 1, characterized in that: The shaping drying is carried out at a temperature of 30-35°C and a relative air humidity of 20-25%, and air drying is carried out for 3-4 hours.

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