Traditional Chinese medicine compound preparation for promoting digestion and reducing phlegm and preparation method thereof

Abstract

The traditional Chinese medicine compound preparation is prepared from the following raw materials: 120 to 180 parts of fructus crataegi, 120 to 180 parts of fructus hordei germinatus, 120 to 180 parts of medicated leaven, 180 to 220 parts of pericarpium citri reticulatae, 120 to 150 parts of fructus trichosanthis, 120 to 150 parts of semen raphani, 80 to 120 parts of fructus citri, 80 to 120 parts of semen arecae, 100 to 140 parts of folium perillae, 50 to 80 parts of radix platycodonis, 40 to 60 parts of radix ophiopogonis, 60 to 80 parts of rhizoma atractylodis, 20 to 40 parts of radix astragali seu hedysari and 0.5 to 1.5 parts of peppermint oil. According to the traditional Chinese medicine compound preparation disclosed by the invention, the platycodon grandiflorum, the radix ophiopogonis, the rhizoma atractylodis and the astragalus mongholicus are added on the basis of food digestion, and the platycodon grandiflorum has the effects of diffusing the lung, relieving sore throat, eliminating phlegm and expelling pus; the radix ophiopogonis has the effects of nourishing yin, promoting salivation, clearing away lung-heat, diminishing inflammation and resisting bacteria; rhizoma atractylodis is used for drying dampness and tonifying spleen; the astragalus membranaceus is used for tonifying qi and raising yang; by adjusting the ratio of the raw materials, the prepared traditional Chinese medicine compound preparation has excellent treatment effects on the symptoms such as food retention, abdominal fullness and distention, putrid belching and poor appetite, phlegm-dampness accumulation, excessive phlegm and the like, and the purpose of quickly curing food impairment caused by external infection is achieved.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine compound preparation for digestion and phlegm reduction and a preparation method thereof. Background Art

[0002] External food poisoning generally has symptoms such as vomiting, loss of appetite, abdominal distension and pain, runny nose, phlegm, and headache. Traditional Chinese medicine often uses combined treatment with drugs that can help digestion and resolve phlegm to achieve the effect of digesting food and resolving phlegm.

[0003] At present, the treatment drugs for exogenous food injury include Chinese medicines such as Shixiaoyin and Jianweixiaoshi tablets. Shixiaoyin is made of hawthorn, malt, Liushenqu, tangerine peel, trichosanthes, radish seed, citron, areca nut, perilla leaf and peppermint oil in a certain proportion. The medicine has the effects of digesting food and relieving stagnation, removing accumulation and relieving bloating, and regulating the stomach and intestines. It is used for abdominal distension, indigestion, belching and poor appetite. It has excellent effect on digestion. In addition, it also has certain effect on internal accumulation of phlegm and dampness, but the effect is not ideal and cannot achieve a good therapeutic effect. Summary of the invention

[0004] The purpose of the present invention is to provide a Chinese herbal compound preparation for digestion and phlegm reduction and a preparation method thereof. Based on the formula of food-digesting drink, the present invention adds new components and adjusts the ratio of various raw materials, so that the prepared Chinese herbal compound preparation has excellent therapeutic effects on symptoms such as indigestion, abdominal distension, belching, poor appetite, internal accumulation of phlegm and dampness, and excessive phlegm.

[0005] In order to achieve the above-mentioned purpose of the present invention, the following technical solutions are particularly adopted:

[0006] The first aspect of the present invention provides a Chinese medicinal compound preparation for digestion and phlegm reduction, wherein the Chinese medicinal compound preparation is prepared from the following raw materials:

[0007] 120-180 parts of hawthorn, 120-180 parts of malt, 120-180 parts of Liushenqu, 180-220 parts of dried tangerine peel, 120-150 parts of trichosanthes, 120-150 parts of radish seeds, 80-120 parts of citron, 80-120 parts of betel nut, 100-140 parts of perilla leaves, 50-80 parts of platycodon, 40-60 parts of ophiopogon, 60-80 parts of atractylodes, 20-40 parts of astragalus and 0.5-1.5 parts of peppermint oil.

[0008] Preferably, the Chinese medicine compound preparation is prepared from the following raw materials:

[0009] 150 parts of hawthorn, 150 parts of malt, 150 parts of Liushenqu, 200 parts of dried orange peel, 140 parts of trichosanthes, 140 parts of radish seeds, 100 parts of citron, 100 parts of areca nuts, 120 parts of perilla leaves, 60 parts of platycodon, 50 parts of ophiopogon, 70 parts of atractylodes, 30 parts of astragalus and 1 part of peppermint oil.

[0010] Preferably, the dosage form of the Chinese medicine compound preparation is tablets and granules.

[0011] Preferably, the Chinese medicine compound preparation also includes pharmaceutically acceptable excipients.

[0012] Preferably, the auxiliary materials include sucrose, starch, dextrin and sodium hydroxymethylcellulose.

[0013] The second aspect of the present invention provides a method for preparing a Chinese medicine compound preparation, the preparation method comprising the following steps:

[0014] (a) crushing hawthorn, trichosanthes, radish seeds and betel nuts, placing them in water, adding bromelain and cellulase for enzymolysis, then boiling for 2 to 4 hours, filtering, collecting the filtrate, adding anhydrous ethanol to the filtrate until the ethanol content is not less than 65% for alcohol precipitation, and collecting the supernatant;

[0015] (b) pulverizing malt, Liushenqu, dried orange peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus, then mixing the pulverized raw materials with water and adding papain and cellulase for enzymolysis, then adding anhydrous ethanol to an ethanol concentration of 20% to 30% to soak for a period of time, then filtering and collecting the filtrate;

[0016] (c) mixing the supernatant of step (a) and the filtrate of step (b) to obtain a paste, adding auxiliary materials to prepare a corresponding dosage form, and spraying peppermint oil to obtain the Chinese medicine compound preparation.

[0017] Preferably, in the step (a), the amount of bromelain added is 0.5% to 3% of the total mass of hawthorn, trichosanthes, radish seeds and areca nut, and the amount of cellulase added is 0.2% to 1% of the total mass of hawthorn, trichosanthes, radish seeds and areca nut; the enzymolysis temperature is 50 to 55° C., and the time is 2 to 4 hours.

[0018] Preferably, in the step (b), the amount of papain added is 0.2% to 2% of the total mass of malt, Liushenqu, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the amount of cellulase added is 0.2% to 1% of the total mass of malt, Liushenqu, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the enzymolysis temperature is 50 to 55°C, and the time is 3 to 5h

[0019] The soaking period is 12 to 24 hours.

[0020] Preferably, in step (c), the auxiliary material is selected from at least one of sucrose, starch, dextrin and sodium hydroxymethyl cellulose.

[0021] Compared with the prior art, the beneficial effects of the present invention include at least:

[0022] In the Chinese medicine compound preparation of the present invention, platycodon, ophiopogon, atractylodes and astragalus are added to the food and digestion drink. Platycodon has the effects of clearing the lungs, relieving sore throat, removing phlegm and discharging pus; ophiopogon has the effects of nourishing yin and promoting body fluid, clearing the lungs and clearing the heart, and reducing inflammation and resisting bacteria; atractylodes is used for drying dampness and strengthening the spleen; and astragalus is used for replenishing qi and raising yang. By adjusting the proportions of various raw materials, the prepared Chinese medicine compound preparation has excellent therapeutic effects on symptoms such as indigestion, abdominal distension, belching and poor appetite, internal accumulation of phlegm and dampness, and excessive phlegm, thereby achieving the purpose of quickly curing exogenous food damage.

[0023] The preparation method of the present invention can better improve the overall efficacy of the prepared Chinese medicine compound preparation by extracting each raw material component separately and performing enzymolysis treatment on different raw materials using specific enzymes, thereby achieving a better therapeutic effect on exogenous food poisoning. DETAILED DESCRIPTION

[0024] The following embodiments of the technical solution of the present invention are described in detail in conjunction with the embodiments. The following embodiments are only used to more clearly illustrate the technical solution of the present invention, and are therefore only used as examples, and cannot be used to limit the protection scope of the present invention.

[0025] It should be noted that, unless otherwise specified, the technical terms or scientific terms used in this application should have the common meanings understood by those skilled in the art to which the present invention belongs.

[0026] Example 1

[0027] This embodiment is a Chinese medicine compound preparation for digestion and phlegm reduction, which is prepared from the following raw materials:

[0028] 120 parts of hawthorn, 180 parts of malt, 180 parts of Liushenqu, 180 parts of dried orange peel, 120 parts of trichosanthes, 120 parts of radish seeds, 120 parts of citron, 120 parts of areca nuts, 100 parts of perilla leaves, 80 parts of platycodon, 60 parts of ophiopogon, 60 parts of atractylodes, 40 parts of astragalus and 0.5 parts of peppermint oil;

[0029] The Chinese medicine compound preparation also includes pharmaceutically acceptable excipients, which are sucrose and starch in a mass ratio of 2:1;

[0030] The preparation method of the above-mentioned Chinese medicine compound preparation comprises the following steps:

[0031] (a) crushing hawthorn, trichosanthes, radish seeds and betel nut, placing them in water, adding bromelain and cellulase for enzymolysis, then boiling for 2 hours, filtering, collecting the filtrate, adding anhydrous ethanol to the filtrate until the ethanol content is 70% for alcohol precipitation, and collecting the supernatant, wherein the amount of bromelain added is 0.5% of the total mass of hawthorn, trichosanthes, radish seeds and betel nut, and the amount of cellulase added is 0.2% of the total mass of hawthorn, trichosanthes, radish seeds and betel nut; the enzymolysis temperature is 50-55° C., and the time is 4 hours;

[0032] (b) pulverizing malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus, then mixing the pulverized raw materials with water and adding papain and cellulase for enzymolysis, then adding anhydrous ethanol to an ethanol concentration of 20% and soaking for 24 hours, then filtering and collecting the filtrate, wherein the amount of papain added is 0.2% of the total mass of malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the amount of cellulase added is 0.2% of the total mass of malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the enzymolysis temperature is 50-55° C. and the time is 5 hours;

[0033] (c) mixing the supernatant of step (a) and the filtrate of step (b) to obtain a paste, adding auxiliary materials (the auxiliary materials are 7 times the mass of the paste) and preparing granules, spraying peppermint oil on the surface of the granules, and obtaining the above-mentioned Chinese medicine compound preparation.

[0034] Example 2

[0035] This embodiment is a Chinese medicine compound preparation (tablet) for digestion and phlegm reduction, which is prepared from the following raw materials:

[0036] 180 parts of hawthorn, 120 parts of malt, 120 parts of Liushenqu, 220 parts of dried orange peel, 150 parts of trichosanthes, 150 parts of radish seeds, 80 parts of citron, 80 parts of areca nut, 140 parts of perilla leaves, 50 parts of platycodon, 40 parts of ophiopogon, 80 parts of atractylodes, 20 parts of astragalus and 1.5 parts of peppermint oil;

[0037] The Chinese medicine compound preparation also includes pharmaceutically acceptable excipients, which are sucrose, starch and sodium hydroxymethyl cellulose in a mass ratio of 2:1:1;

[0038] The preparation method of the above-mentioned Chinese medicine compound preparation comprises the following steps:

[0039] (a) crushing hawthorn, trichosanthes, radish seeds and betel nut, placing them in water, adding bromelain and cellulase for enzymolysis, then boiling for 4 hours, filtering, collecting the filtrate, adding anhydrous ethanol to the filtrate until the ethanol content is 70% for alcohol precipitation, and collecting the supernatant, wherein the amount of bromelain added is 3% of the total mass of hawthorn, trichosanthes, radish seeds and betel nut, and the amount of cellulase added is 1% of the total mass of hawthorn, trichosanthes, radish seeds and betel nut; the enzymolysis temperature is 50-55° C., and the time is 2 hours;

[0040] (b) pulverizing malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus, then mixing the pulverized raw materials with water and adding papain and cellulase for enzymolysis, then adding anhydrous ethanol to an ethanol concentration of 30% and soaking for 12 hours, then filtering and collecting the filtrate, wherein the amount of papain added is 2% of the total mass of malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the amount of cellulase added is 1% of the total mass of malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the enzymolysis temperature is 50-55° C. and the time is 3 hours;

[0041] (c) mixing the supernatant of step (a) and the filtrate of step (b) to obtain a paste, adding auxiliary materials (the auxiliary materials are 7 times the mass of the paste) and making tablets, spraying peppermint oil on the surface of the tablets, and obtaining the above-mentioned Chinese medicine compound preparation.

[0042] Example 3

[0043] This embodiment is a Chinese medicine compound preparation (granules) for digestion and phlegm reduction, which is prepared from the following raw materials:

[0044] 150 parts of hawthorn, 150 parts of malt, 150 parts of Liushenqu, 200 parts of dried orange peel, 140 parts of trichosanthes, 140 parts of radish seeds, 100 parts of citron, 100 parts of areca nut, 120 parts of perilla leaves, 60 parts of platycodon, 50 parts of ophiopogon, 70 parts of atractylodes, 30 parts of astragalus and 1 part of peppermint oil;

[0045] The Chinese medicine compound preparation also includes pharmaceutically acceptable excipients, which are sucrose;

[0046] The preparation method of the above-mentioned Chinese medicine compound preparation comprises the following steps:

[0047] (a) crushing hawthorn, trichosanthes, radish seeds and betel nut, placing them in water, adding bromelain and cellulase for enzymolysis, then boiling for 3 hours, filtering, collecting the filtrate, adding anhydrous ethanol to the filtrate until the ethanol content is 70% for alcohol precipitation, and collecting the supernatant, wherein the amount of bromelain added is 2% of the total mass of hawthorn, trichosanthes, radish seeds and betel nut, and the amount of cellulase added is 0.5% of the total mass of hawthorn, trichosanthes, radish seeds and betel nut; the enzymolysis temperature is 50-55° C., and the time is 3 hours;

[0048] (b) pulverizing malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus, then mixing the pulverized raw materials with water and adding papain and cellulase for enzymolysis, then adding anhydrous ethanol to an ethanol concentration of 25% and soaking for 18 hours, then filtering and collecting the filtrate, wherein the amount of papain added is 1% of the total mass of malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the amount of cellulase added is 0.5% of the total mass of malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the enzymolysis temperature is 50-55° C. and the time is 4 hours;

[0049] (c) mixing the supernatant of step (a) and the filtrate of step (b) to obtain a paste, adding auxiliary materials (the auxiliary materials are 7 times the mass of the paste) and preparing granules, spraying peppermint oil on the surface of the granules, and obtaining the above-mentioned Chinese medicine compound preparation.

[0050] Comparative Example 1

[0051] This comparative example is a Chinese medicine compound preparation (granules) for digestion and phlegm reduction, which is prepared from the following raw materials:

[0052] 150 parts of hawthorn, 150 parts of malt, 150 parts of Liushenqu, 200 parts of dried orange peel, 140 parts of trichosanthes, 140 parts of radish seeds, 100 parts of citron, 100 parts of areca nut, 120 parts of perilla leaves, 60 parts of platycodon, 50 parts of ophiopogon, 100 parts of atractylodes and 1 part of peppermint oil;

[0053] The Chinese medicine compound preparation also includes pharmaceutically acceptable excipients, which are sucrose;

[0054] The preparation method of the above-mentioned Chinese medicine compound preparation comprises the following steps:

[0055] (a) crushing hawthorn, trichosanthes, radish seeds and betel nut, placing them in water, adding bromelain and cellulase for enzymolysis, then boiling for 3 hours, filtering, collecting the filtrate, adding anhydrous ethanol to the filtrate until the ethanol content is 70% for alcohol precipitation, collecting the supernatant pineapple, wherein the amount of bromelain added is 2% of the total mass of hawthorn, trichosanthes, radish seeds and betel nut, and the amount of cellulase added is 0.5% of the total mass of hawthorn, trichosanthes, radish seeds and betel nut; the enzymolysis temperature is 50-55°C, and the time is 3 hours;

[0056] (b) pulverizing malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon and atractylodes, then mixing the pulverized raw materials with water and adding papain and cellulase for enzymolysis, then adding anhydrous ethanol to an ethanol concentration of 25% and soaking for 18 hours, then filtering and collecting the filtrate, wherein the amount of papain added is 1% of the total mass of malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the amount of cellulase added is 0.5% of the total mass of malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the enzymolysis temperature is 50-55° C. and the time is 4 hours;

[0057] (c) mixing the supernatant of step (a) and the filtrate of step (b) to obtain a paste, adding auxiliary materials (the auxiliary materials are 7 times the mass of the paste) and preparing granules, spraying peppermint oil on the surface of the granules, and obtaining the above-mentioned Chinese medicine compound preparation.

[0058] Comparative Example 2

[0059] This embodiment is a Chinese medicine compound preparation (granules) for digestion and phlegm reduction, which is prepared from the following raw materials:

[0060] 150 parts of hawthorn, 150 parts of malt, 150 parts of Liushenqu, 200 parts of dried orange peel, 140 parts of trichosanthes, 140 parts of radish seeds, 100 parts of citron, 100 parts of areca nut, 120 parts of perilla leaves, 60 parts of platycodon, 50 parts of ophiopogon, 70 parts of atractylodes, 30 parts of astragalus and 1 part of peppermint oil;

[0061] The Chinese medicine compound preparation also includes pharmaceutically acceptable excipients, which are sucrose;

[0062] The preparation method of the above-mentioned Chinese medicine compound preparation comprises the following steps:

[0063] (a) crushing hawthorn, trichosanthes, radish seeds and betel nut, placing them in water, adding papain and cellulase for enzymolysis, then boiling for 3 hours, filtering, collecting the filtrate, adding anhydrous ethanol to the filtrate until the ethanol content is 70% for alcohol precipitation, collecting the supernatant, wherein the amount of papain added is 2% of the total mass of hawthorn, trichosanthes, radish seeds and betel nut, and the amount of cellulase added is 0.5% of the total mass of hawthorn, trichosanthes, radish seeds and betel nut; the enzymolysis temperature is 50-55°C, and the time is 3 hours;

[0064] (b) pulverizing malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus, then mixing the pulverized raw materials with water and adding bromelain and cellulase for enzymolysis, then adding anhydrous ethanol to an ethanol concentration of 25% and soaking for 18 hours, then filtering and collecting the filtrate, wherein the amount of bromelain added is 1% of the total mass of malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the amount of cellulase added is 0.5% of the total mass of malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the enzymolysis temperature is 50-55° C. and the time is 4 hours;

[0065] (c) mixing the supernatant of step (a) and the filtrate of step (b) to obtain a paste, adding auxiliary materials (the auxiliary materials are 7 times the mass of the paste) and preparing granules, spraying peppermint oil on the surface of the granules, and obtaining the above-mentioned Chinese medicine compound preparation.

[0066] Comparative Example 3

[0067] This comparative example is a Chinese medicine compound preparation (granules) for digestion and phlegm reduction, which is prepared from the following raw materials:

[0068] 150 parts of hawthorn, 150 parts of malt, 150 parts of Liushenqu, 200 parts of dried orange peel, 140 parts of trichosanthes, 140 parts of radish seeds, 100 parts of citron, 100 parts of areca nut, 120 parts of perilla leaves, 60 parts of platycodon, 50 parts of ophiopogon, 70 parts of atractylodes, 30 parts of astragalus and 1 part of peppermint oil;

[0069] The Chinese medicine compound preparation also includes pharmaceutically acceptable excipients, which are sucrose;

[0070] The preparation method of the above-mentioned Chinese medicine compound preparation comprises the following steps:

[0071] (a) crushing hawthorn, trichosanthes, radish seeds and betel nut, placing them in water, adding trypsin and cellulase for enzymolysis, then boiling for 3 hours, filtering, collecting the filtrate, adding anhydrous ethanol to the filtrate until the ethanol content is 70% for alcohol precipitation, and collecting the supernatant, wherein the amount of trypsin added is 2% of the total mass of hawthorn, trichosanthes, radish seeds and betel nut, and the amount of cellulase added is 0.5% of the total mass of hawthorn, trichosanthes, radish seeds and betel nut; the enzymolysis temperature is 50-55°C, and the time is 3 hours;

[0072] (b) pulverizing malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus, then mixing the pulverized raw materials with water and adding trypsin and cellulase for enzymolysis, then adding anhydrous ethanol to an ethanol concentration of 25% and soaking for 18 hours, then filtering and collecting the filtrate, wherein the addition amount of trypsin is 1% of the total mass of malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the addition amount of cellulase is 0.5% of the total mass of malt, six-spirit song, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the enzymolysis temperature is 50-55° C. and the time is 4 hours;

[0073] (c) mixing the supernatant of step (a) and the filtrate of step (b) to obtain a paste, adding auxiliary materials (the auxiliary materials are 7 times the mass of the paste) and preparing granules, spraying peppermint oil on the surface of the granules, and obtaining the above-mentioned Chinese medicine compound preparation.

[0074] Experimental example

[0075] Experimental drugs: the Chinese medicine compound preparations of Example 3 and Comparative Examples 1 to 3 and commercially available food and beverages;

[0076] Patients with symptoms of indigestion, abdominal distension, nausea, vomiting, loss of appetite, and sputum were selected. The Chinese medicine compound of Example 3 directly treated 63 cases in total, the Chinese medicine compound preparation of Comparative Example 1 treated 27 cases in total, the Chinese medicine compound preparation of Comparative Example 2 treated 36 cases in total, the Chinese medicine compound preparation of Comparative Example 3 treated 25 cases in total, and the commercially available food-promoting drink treated 45 cases in total;

[0077] Treatment method: Take with boiled water, 15 servings each time, three times a day. After taking it for 2 days, call back to conduct a questionnaire survey. The questionnaire questions include the presence of various symptoms;

[0078] Efficacy evaluation criteria:

[0079] Markedly effective: All symptoms disappeared;

[0080] Effective: at least one symptom is relieved;

[0081] Ineffective: Symptoms remain unchanged or worsen.

[0082] The efficacy of each patient was statistically analyzed, and the statistical results are shown in Table 1:

[0083] Table 1

[0084] Group Significant effect (people) Effective (person) Invalid (person) Example 3 52 10 1 Comparative Example 1 18 9 0 Comparative Example 2 21 13 2 Comparative Example 3 12 8 5 Commercially available food and beverage 31 11 3

[0085] From Table 1, we can see that:

[0086] The Chinese herbal compound preparations prepared in Example 3 of the present application and Comparative Examples 1 to 3 and the commercially available food-digesting drink can improve the symptoms of indigestion, abdominal distension, nausea, vomiting, loss of appetite, and excessive sputum. Compared with the comparative examples, the Chinese herbal compound preparations prepared in Example 3 of the present application have better therapeutic effects.

[0087] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein by equivalents. These modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present invention, and they should all be included in the scope of the claims and specification of the present invention.

Claims

1. A Chinese medicinal compound preparation for digestion and phlegm reduction, characterized in that: The Chinese medicine compound preparation is prepared from the following raw materials: 120-180 parts of hawthorn, 120-180 parts of malt, 120-180 parts of Liushenqu, 180-220 parts of dried tangerine peel, 120-150 parts of trichosanthes, 120-150 parts of radish seeds, 80-120 parts of citron, 80-120 parts of betel nut, 100-140 parts of perilla leaves, 50-80 parts of platycodon, 40-60 parts of ophiopogon, 60-80 parts of atractylodes, 20-40 parts of astragalus and 0.5-1.5 parts of peppermint oil.

2. The Chinese medicinal compound preparation according to claim 1, characterized in that: The Chinese medicine compound preparation is prepared from the following raw materials: 150 parts of hawthorn, 150 parts of malt, 150 parts of Liushenqu, 200 parts of dried orange peel, 140 parts of trichosanthes, 140 parts of radish seeds, 100 parts of citron, 100 parts of areca nuts, 120 parts of perilla leaves, 60 parts of platycodon, 50 parts of ophiopogon, 70 parts of atractylodes, 30 parts of astragalus and 1 part of peppermint oil.

3. The Chinese medicinal compound preparation according to claim 1 or 2, characterized in that: The dosage form of the Chinese medicine compound preparation is tablets and granules.

4. The Chinese medicinal compound preparation according to claim 1 or 2, characterized in that: The traditional Chinese medicine compound preparation also includes pharmaceutically acceptable auxiliary materials.

5. The Chinese medicinal compound preparation according to claim 4, characterized in that: The auxiliary materials include sucrose, starch, dextrin and sodium hydroxymethylcellulose.

6. The method for preparing the Chinese medicinal compound preparation according to any one of claims 1 to 5, characterized in that: The steps include: (a) crushing hawthorn, trichosanthes, radish seeds and betel nuts, placing them in water, adding bromelain and cellulase for enzymolysis, then boiling for 2 to 4 hours, filtering, collecting the filtrate, adding anhydrous ethanol to the filtrate until the ethanol content is not less than 65% for alcohol precipitation, and collecting the supernatant; (b) pulverizing malt, Liushenqu, dried orange peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus, then mixing the pulverized raw materials with water and adding papain and cellulase for enzymolysis, then adding anhydrous ethanol to an ethanol concentration of 20% to 30% to soak for a period of time, then filtering and collecting the filtrate; (c) mixing the supernatant of step (a) and the filtrate of step (b) to obtain a paste, adding auxiliary materials to prepare a corresponding dosage form, and spraying peppermint oil to obtain the Chinese medicine compound preparation.

7. The preparation method according to claim 6, characterized in that: In the step (a), the amount of bromelain added is 0.5% to 3% of the total mass of hawthorn, trichosanthes, radish seeds and areca nut, and the amount of cellulase added is 0.2% to 1% of the total mass of hawthorn, trichosanthes, radish seeds and areca nut; the enzymolysis temperature is 50 to 55° C., and the time is 2 to 4 hours.

8. The preparation method according to claim 6, characterized in that: In the step (b), the amount of papain added is 0.2% to 2% of the total mass of malt, Liushenqu, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the amount of cellulase added is 0.2% to 1% of the total mass of malt, Liushenqu, tangerine peel, citron, perilla leaf, platycodon, ophiopogon, atractylodes and astragalus; the enzymolysis temperature is 50 to 55° C., and the time is 3 to 5 hours The soaking period is 12 to 24 hours.

9. The preparation method according to claim 6, characterized in that: In the step (c), the auxiliary material is selected from at least one of sucrose, starch, dextrin and sodium hydroxymethyl cellulose.