Medical sealant coating device and method

Abstract

The invention discloses a medical sealant coating device and method. The medical sealant coating device comprises a workbench, a feeding mechanism, a sealant rolling mechanism and a sealant coating mechanism, wherein the feeding mechanism, the sealant rolling mechanism and the sealant coating mechanism are arranged on the workbench; the glue rolling mechanism is used for clamping the guide pipe, controlling the pipe orifice of the guide pipe to be upward in a vertical state and driving the clamp to rotate at a constant speed along the axis of the guide pipe; the gluing mechanism comprises a displacement assembly and a dispensing roller arranged on one side of the displacement assembly; the glue dispensing roller is a hollow cylinder which is vertically arranged, and the displacement assembly drives the glue dispensing roller to move downwards, so that the inner wall of the glue dispensing roller is attached to the outer wall of the pipe opening of the guide pipe, and sealant is coated on the glue dispensing roller. The sealant in the dispensing roller flows out through the multiple sealant outlets, the rotating assembly drives the guide pipe to rotate along the axis of the guide pipe, and the dynamic coating mode ensures that the sealant is evenly distributed on the outer wall of the pipe opening of the guide pipe. Compared with traditional static coating or vertical downward flow coating, the problem that the coating thickness is not uniform due to uneven flow is effectively solved.

Description

Technical Field

[0001] The invention relates to the technical field of glue coating, and in particular to a medical sealant coating device and method. Background Art

[0002] During the production process of the urine collection bag, a catheter needs to be connected to the inlet / outlet of the bag. The conventional connection method is: apply a layer of epoxy adhesive on the surface of the catheter joint, then insert it into the designated position of the inlet / outlet of the bag, and then heat and cure it to make it tightly connected and ensure the sealing performance of the urine collection bag.

[0003] However, epoxy adhesives will release some toxic gases during the curing process. The sources of the gases may include the diluent in the epoxy resin, and the amines or anhydrides in the curing agent. Part of this slightly toxic gas escapes into the production workshop during the curing process, and the other part remains in the urine collection bag. During the use of these urine collection bags, this slightly toxic gas may enter the human body along the catheter and endanger human health. In addition, when the existing glue coating device is coating the joint surface with glue, the glue is not sufficiently fluid and cannot be evenly coated on the joint surface, resulting in insufficient sealing of the urine collection bag.

[0004] Therefore, it is necessary to provide a medical sealant coating device and method to solve the above technical problems. Summary of the invention

[0005] The invention overcomes the shortcomings of the prior art and provides a medical sealant coating device and method.

[0006] To achieve the above object, the technical solution adopted by the present invention is: a medical sealant coating device, comprising: a workbench, a feeding mechanism, a glue rolling mechanism and a glue coating mechanism arranged on the workbench; the feeding mechanism is arranged on one side of the glue rolling mechanism; The rubber rolling mechanism comprises: a rotating assembly, and a clamp arranged on the rotating assembly; the clamp is used to clamp the catheter and control the tube mouth of the catheter to be in a vertical state upward; the rotating assembly is used to drive the clamp to rotate at a constant speed along the central axis of the catheter; The feeding mechanism is used to grab the catheter and move it to a designated position of the fixture; The glue coating mechanism is arranged above the glue rolling mechanism; Among them, the glue coating mechanism includes: a displacement component and a glue dispensing roller arranged on one side of the displacement component; the glue dispensing roller has an outer shape of a vertically arranged hollow cylinder, and the displacement component drives the glue dispensing roller to move downward so that the inner wall of the glue dispensing roller fits with the outer wall of the catheter nozzle and sealant is coated on it; the sealant is a modified epoxy resin adhesive.

[0007] In a preferred embodiment of the present invention, the displacement assembly includes: a guide rail arranged on the upper surface of the workbench, a slide arranged on the guide rail, and a driving unit for controlling the movement of the slide; wherein, the guide rail is arranged vertically, and the slide moves vertically on the guide rail, and the glue dispensing roller is arranged on the surface of the slide.

[0008] In a preferred embodiment of the present invention, the lower end face of the glue dispensing roller is grooved so that the glue dispensing roller is sleeved on the upper end of the conduit, and the glue dispensing roller includes: a glue flow cavity, and a plurality of glue outlets opened on the side wall of the glue flow cavity; the plurality of glue outlets are divided into an upper glue outlet and a middle glue outlet according to their heights on the inner wall of the glue dispensing roller.

[0009] In a preferred embodiment of the present invention, a vertical support rod is disposed inside the glue dispensing roller, and the support rod is a cylinder and is disposed at the center of the glue dispensing roller; and the diameter of the support rod is smaller than the inner diameter of the catheter.

[0010] In a preferred embodiment of the present invention, the modified epoxy resin adhesive comprises, by weight: 100 parts of epoxy resin, 15-20 parts of modified polydimethylsiloxane, 15-25 parts of toughening agent, 32-40 parts of curing agent mixture and 10-15 parts of diluent.

[0011] In a preferred embodiment of the present invention, the method for preparing the modified polydimethylsiloxane comprises the following steps: Step 1, mixing and stirring vinyl-polydimethylsiloxane, hydrogen-polydimethylsiloxane and platinum catalyst evenly; wherein the mass ratio of vinyl-polydimethylsiloxane, hydrogen-polydimethylsiloxane and platinum catalyst is 1:1.1-1.5:0.02-0.05; Step 2: react the mixture at 170° C. to 210° C. for 3 to 5 hours to obtain modified polydimethylsiloxane.

[0012] In a preferred embodiment of the present invention, the method for preparing the modified epoxy resin adhesive comprises the following steps: Step 1: Mix epoxy resin, modified polydimethylsiloxane, toughening agent, curing agent mixture, diluent and toluene solution according to weight, add them into a powerful mixer, and stir for 20 to 30 minutes to obtain a transparent solution; Step 2: Place the transparent solution in a vacuum box for curing. The toluene is completely volatilized before the mixed system reaches the gel point. The curing temperature is 170°C to 210°C. The reaction time is 12 to 16 hours to obtain a translucent to transparent modified epoxy resin adhesive product.

[0013] A method for applying medical sealant, based on any one of the medical sealant applying devices described above, comprises the following steps: Step S1, grab the catheter and move it to a designated position of the clamp for fixing, after which the catheter is fixed with the tube opening facing upwards in a vertical state; Step S2, the glue dispensing roller moves downward and is sleeved on the upper end of the catheter, and the inner wall of the glue dispensing roller is in contact with the outer wall of the catheter orifice; Step S3, controlling the catheter to rotate at a constant speed along its axis; Step S4, the glue dispensing roller discharges glue, the temperature of the sealant is controlled at 35-40° C., the glue discharge amount is 5-6 ml / min, and the glue is continuously discharged for 5-8 seconds to complete the glue coating.

[0014] In a preferred embodiment of the present invention, in said S3, the rotation rate of the catheter is 50-60 RPM / min.

[0015] In a preferred embodiment of the present invention, the method further comprises: after the glue coating is completed, the glue dispensing roller moves upward, and after the catheter is controlled to continue rotating for 5 to 10 seconds, the catheter is removed and connected to the urine collection bag interface.

[0016] The present invention solves the defects existing in the background technology and has the following beneficial effects: The present invention provides a medical sealant coating device and method. The sealant in the dispensing roller flows out through a plurality of glue outlets, and the rotating component drives the catheter to rotate along its axis. This dynamic coating method ensures the uniform distribution of the sealant on the outer wall of the catheter tube. Compared with traditional static coating or vertical downflow coating, the present invention effectively avoids the problem of uneven coating thickness caused by uneven flow. In addition, the sealant uses a modified epoxy resin adhesive, which reduces the overflow of harmful gases during the curing process after coating.

[0017] The present invention also provides a method for preparing a modified epoxy resin adhesive, and prepares a modified epoxy resin adhesive with a PIN structure, forming an epoxy resin / polydimethylsiloxane interpenetrating network with a minimum phase domain size of 5 nanometers. The two polymer networks are intertwined without forming covalent bonds. The interpenetrating network structure improves the toughness and thermal stability of the epoxy resin, reduces the internal stress and thermal decomposition during the curing process, and thus effectively reduces the escape of harmful gases in the epoxy resin.

[0018] In the present invention, the component ratio of the modified epoxy resin adhesive is controlled so that the adhesive not only achieves the environmental protection standard of a volatile organic compound (VOC) content of less than 300 g / L, but also effectively solves the following problems caused by the introduction of polydimethylsiloxane into the epoxy resin: due to its large molecular weight and poor compatibility with the epoxy resin, the cross-linked network structure formed by the epoxy resin and the polydimethylsiloxane will restrict the movement of the epoxy resin molecular chain, thereby causing the problem of insufficient fluidity.

[0019] The present invention provides a method for coating medical sealant, which can ensure that the sealant is evenly distributed on the outer wall of the catheter orifice by controlling the uniform rotation of the catheter along its axis and the precise dispensing of the glue at a fixed position of the glue dispensing roller. The modified epoxy resin adhesive of the present invention is used, which not only reduces the emission of slightly toxic gas during the curing process of the sealant, but also avoids the problem of uneven coating thickness caused by uneven flow. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art are briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative work. Figure 1 It is a schematic diagram of the overall structure of a preferred embodiment of the present invention; Figure 2 is a three-dimensional structural diagram of a preferred embodiment of the present invention; Figure 3 is a cross-sectional view of a dispensing roller according to a preferred embodiment of the present invention; In the figure: 100, workbench; 200, glue rolling mechanism; 210, rotating component; 220, fixture; 300, glue coating mechanism; 310, displacement component; 320, glue dispensing roller; 321, glue flow chamber; 322, glue outlet. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein. Therefore, the protection scope of the present invention is not limited to the specific embodiments disclosed below.

[0023] In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the scope of protection of the present application. In addition, the terms "first", "second", etc. are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, features defined as "first", "second", etc. may explicitly or implicitly include one or more of the features. In the description of the invention, unless otherwise specified, "multiple" means two or more.

[0024] In the description of this application, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood by specific circumstances.

[0025] The surface of the inlet / drainage pipe joints of some urine collection bags is not smooth, but has gaps or spiral patterns. This design is intended to make the connection between the catheter and the urine collection bag tighter, but it hinders the uniformity of glue coating.

[0026] like Figure 1 and Figure 2 As shown, the present invention provides a medical sealant coating device, comprising: a workbench 100, a feeding mechanism, a glue rolling mechanism 200 and a glue coating mechanism 300 arranged on the workbench 100; characterized in that the feeding mechanism is arranged on one side of the glue rolling mechanism 200; the glue rolling mechanism 200 comprises: a rotating component 210, and a clamp 220 arranged on the rotating component 210; the clamp 220 is used to clamp the catheter and control the tube mouth of the catheter to be in a vertical state upward; the rotating component 210 is used to drive the clamp 220 to rotate at a uniform speed along the central axis of the catheter.

[0027] The fixture 220 is arranged at the center position of the rotating assembly 210, and the rotating assembly 210 includes: a rotating table arranged on the upper surface of the workbench 100, and a first servo motor arranged on the lower side of the workbench 100; the first servo motor drives the rotating table to rotate through a gear set, wherein the gear set includes: a driving gear and a passive gear in meshing connection; the output end of the first servo motor is connected to the driving gear, the lower surface of the rotating table is fixedly connected to the passive gear, and the lower surface of the rotating table is connected to the workbench 100 through a rolling bearing, and the rotating table and the passive gear rotate synchronously. It is worth noting that the surface of the rotating disk is provided with a conduit groove that runs through the rotating disk, the workbench 100 and the passive gear, and the conduit groove, the rotating disk and the passive gear are arranged to be concentric, and the inner diameter of the conduit groove is much larger than the conduit diameter.

[0028] The clamp 220 in this embodiment includes: electric push rods distributed on both sides of the catheter groove, and a clamping member arranged at the movable end of the electric push rod. The two electric push rods are in a straight line, both fixed on the upper surface of the rotating disk, and the movable ends of the electric push rods are facing the center of the catheter groove. Among them, the clamping member includes: a connecting part fixed to the movable end of the electric push rod, a retaining part arranged on the side of the connecting part close to the catheter groove, the retaining part is semi-cylindrical, and the retaining parts on both sides are connected and combined into a cylinder, the inner diameter of the cylinder matches the outer diameter of the catheter, the catheter is inserted into the cylinder and remains relatively fixed, and the pipe mouth is in a vertical state facing upward.

[0029] In one embodiment, a feeding area is provided on or on one side of the workbench 100 , and the feeding area can be one or more storage boxes for storing the uncoated catheters. In another embodiment, the feeding area is a conveyor belt for conveying the catheters to one side of the workbench 100 .

[0030] In the present invention, the feeding mechanism is specifically a mechanical gripper, which is equipped with an identification system and an alignment system. Among them, the identification system is used to identify the catheter from the storage box or the conveyor belt, as well as the local grasping position. According to the grasping position output by the identification system, the alignment system controls the mechanical gripper to grasp the catheter, and the grasping position is preferably set to the catheter joint position (the joint is the part that docks with the urine collection bag). A multi-directional rotation joint is provided on the mechanical gripper, so that the mechanical gripper can complete different actions and be transferred to the middle of the two clamping parts of the clamp 220 to realize automatic feeding of the catheter. In this embodiment, the mechanical gripper used is a prior art and will not be described in detail here.

[0031] Furthermore, the upper end of the retaining part is open, while the lower end is closed. The two retaining parts are connected and combined to form a cylinder with an open upper end. The length of the cylinder is less than the length of the catheter, so that the tube mouth of the catheter is vertically upward, and the length of the catheter leaking out of the retaining part is consistent, which is convenient for the subsequent glue coating mechanism 300 to coat the sealant on its outer wall.

[0032] In the present invention, the structural design of the holding part enables the conduits of the same size to maintain a uniform shape and position during feeding, with the tube openings facing upward in a vertical state, and the lengths of the conduits leaking out of the holding part are consistent, thereby reducing the alignment operation of the gluing mechanism 300 and improving work efficiency and gluing consistency.

[0033] In the present invention, the glue coating mechanism 300 is arranged above the glue rolling mechanism 200; wherein, the glue coating mechanism 300 includes: a displacement component 310, and a glue dispensing roller 320 arranged on one side of the displacement component 310; the glue dispensing roller 320 has an outer shape of a vertically arranged hollow cylinder, and the displacement component 310 drives the glue dispensing roller 320 to move downward, so that the inner wall of the glue dispensing roller 320 fits with the outer wall of the catheter tube mouth, and sealant is coated on it; the sealant is a modified epoxy resin adhesive.

[0034] The displacement assembly 310 includes: a guide rail arranged on the upper surface of the workbench 100, a slide arranged on the guide rail, and a driving unit for controlling the movement of the slide; wherein the guide rail is arranged vertically, and the slide moves vertically on the guide rail, and the glue dispensing roller 320 is arranged on the surface of the slide, and the slide is driven by the driving unit, thereby driving the glue dispensing roller 320 to move downward, so that the glue dispensing roller 320 is sleeved on the upper end of the catheter, and the inner wall of the glue dispensing roller 320 is in contact with the outer wall of the catheter nozzle, and sealant is applied to it.

[0035] In one embodiment, the driving unit is fixed on the workbench 100. The driving unit is specifically a cylinder. The movable end of the cylinder is fixedly connected to the surface of the slide. The extension and retraction of the cylinder drives the slide to move up and down.

[0036] In another embodiment, the driving unit is fixed on the workbench 100, and the driving unit includes: a second servo motor, and a threaded rod arranged at the output end of the second servo motor; and a threaded hole matching the threaded rod is opened on the slide, and the threaded rod is threadedly connected to the threaded hole. The threaded rod is driven to rotate by the second servo motor, and then the slide moves along the axis of the threaded rod. The connection method between the guide rail and the slide rail can make the slide move up and down without rotating with the threaded rod.

[0037] like Figure 3 As shown, the dispensing roller 320 is specifically a vertical cylinder, which is grooved from the lower end surface so that the dispensing roller 320 is sleeved on the upper end of the conduit. The dispensing roller 320 includes: a glue flow cavity 321, and a plurality of glue outlets 322 opened on the side wall of the glue flow cavity 321; the plurality of glue outlets 322 are divided into an upper layer glue outlet 322 and a middle layer glue outlet 322 according to the height at the inner wall of the dispensing roller 320. In addition, the distance between the center of the upper layer glue outlet 322 and the center of the lower layer glue outlet 322 is equal to the vertical distance from the center of the middle layer glue outlet 322 to the lower end edge of the dispensing roller 320. The plurality of upper layer glue outlets 322 and the middle layer glue outlets 322 are distributed in a circumferential array, and the number of the upper layer glue outlets 322 and the middle layer glue outlets 322 is preferably 3.

[0038] Furthermore, a vertical support rod is provided inside the glue dispensing roller 320. The support rod is a cylinder and is provided at the center of the glue dispensing roller 320. Moreover, the diameter of the support rod is smaller than the inner diameter of the catheter. When dispensing glue, the support rod is inserted into the catheter from the catheter opening to provide support for the soft catheter joint, thereby avoiding the problem of catheter deformation caused by the rotation of the catheter driven by the rotating assembly 210 when applying the sealant.

[0039] The glue coating mechanism 300 in this embodiment further includes: a glue supply component, which delivers sealant to the glue dispensing roller 320. The glue supply component includes: a glue storage tank, a circulation pump connected to the glue storage tank through a pipeline, and a glue delivery pipe connected to the outlet of the circulation pump; the glue storage tank is used to store sealant, and further, a temperature control unit is provided in the glue storage tank to control the temperature of the sealant in the glue storage tank. The other end of the glue delivery pipe is connected to the glue flow cavity 321 to deliver sealant into the glue flow cavity 321.

[0040] In the present invention, the sealant in the flow cavity 321 flows out through a plurality of outlets 322, and the rotating assembly 210 drives the conduit to rotate along its axis. This dynamic coating method ensures that the sealant is evenly distributed on the outer wall of the conduit orifice. Compared with traditional static coating or vertical downflow coating, the present invention effectively avoids the problem of uneven coating thickness caused by uneven flow.

[0041] In particular, for a conduit with a gap or a threaded structure on the outer wall, the continuous rotation of the conduit in the present invention combined with the ingenious structure of the glue dispensing roller 320 not only makes the coating process continuous and uninterrupted, but also helps to smoothly discharge the air from the coating area, thereby reducing the generation of bubbles. In addition, the uniform distribution of the glue during the rotation process also significantly reduces the risk of defects in the glue layer, ensuring the integrity and uniformity of the coating.

[0042] Furthermore, in the present invention, the upper glue outlet 322 and the middle glue outlet 322 are positioned so that when the conduit rotates, the sealant flows downward under the action of gravity, the upper glue flows between the upper layer and the middle layer, and the middle glue flows between the middle layer and the lower layer. By precisely controlling the fluidity of the sealant, the rotation speed of the conduit, and the glue coating time, the sealant is evenly coated on the outer wall of the conduit orifice, and the overflow of the sealant is reduced. The overflow of the sealant will cause glue residue at an unnecessary position on the outer wall of the conduit orifice, which is difficult to clean up later.

[0043] In the present invention, the modified epoxy resin adhesive used for coating comprises, by weight: 100 parts of epoxy resin, 15-25 parts of modified polydimethylsiloxane, 15-25 parts of toughening agent, 32-40 parts of curing agent mixture and 10-15 parts of diluent.

[0044] The raw materials used in this embodiment are as follows: Epoxy resin: epoxy resin EP-15; Toughening agent: carboxyl-terminated nitrile rubber; Diluent: butyl glycidyl ether; Common solvent: toluene; In this embodiment, the preparation method of modified polydimethylsiloxane comprises the following steps: Vinyl-polydimethylsiloxane, hydrogen-polydimethylsiloxane and platinum catalyst are mixed and stirred evenly; wherein the mass ratio of vinyl-polydimethylsiloxane, hydrogen-polydimethylsiloxane and platinum catalyst is 1:1.1-1.3:0.02-0.05.

[0045] The mixture is reacted at 170° C. to 190° C. for 3 to 5 hours to obtain modified polydimethylsiloxane.

[0046] Modified polydimethylsiloxane, vinyl-polydimethylsiloxane and hydrogen-polydimethylsiloxane are prepared through the above steps. Under the action of platinum catalyst, vinyl and hydrogen silane groups undergo addition reaction to form stable Si-C bonds between polydimethylsiloxane chains, thereby promoting the formation of a highly cross-linked three-dimensional network structure and improving the structural density of the interpenetrating network in the subsequently prepared modified epoxy resin adhesive.

[0047] Furthermore, the preparation method of the modified epoxy resin adhesive comprises the following steps: Step 1: Mix epoxy resin, modified polydimethylsiloxane, toughening agent, curing agent mixture, diluent and toluene solution according to weight, add them into a powerful mixer, and stir for 20 to 30 minutes to obtain a transparent solution; Step 2: Place the transparent solution in a vacuum box for curing. The toluene is completely volatilized before the mixed system reaches the gel point. The curing temperature is 170°C to 210°C. The reaction time is 12 to 16 hours to obtain a translucent to transparent modified epoxy resin adhesive product.

[0048] The curing agent mixture includes nano-silicon dioxide and methyl tetrahydroanhydride, and the mass ratio of nano-silicon dioxide to methyl tetrahydroanhydride is 1:4.1-5. Among them, the nano-silicon dioxide, on the one hand, co-cures with the epoxy resin, and on the other hand, hydrogen bonds with the oxygen atoms on the polydimethylsiloxane chain segment, acts as a compatibilizer between the epoxy resin and the polydimethylsiloxane, and promotes the formation of the IPN structure.

[0049] A modified epoxy resin adhesive with a PIN structure is prepared through the above steps, forming an epoxy resin / polydimethylsiloxane interpenetrating network with a minimum domain size of 5 nanometers. The two polymer networks are intertwined without forming covalent bonds. This interpenetrating network structure improves the toughness and thermal stability of the epoxy resin, reduces the internal stress and thermal decomposition during the curing process, and thus effectively reduces the escape of harmful gases in the epoxy resin. Example 1

[0050] This embodiment is based on the above-mentioned method for preparing a modified epoxy resin adhesive. The specific implementation process of preparing a modified epoxy resin adhesive sample is as follows: 1. Preparation of modified polydimethylsiloxane Vinyl-polydimethylsiloxane, hydrogen-polydimethylsiloxane and platinum catalyst are mixed and stirred evenly in a mass ratio of 1:1.2:0.03; The mixture was reacted at 180° C. for 3 h to obtain modified polydimethylsiloxane.

[0051] 2. Preparation of modified epoxy resin adhesive 100 parts of epoxy resin, 15 parts of modified polydimethylsiloxane, 20 parts of toughening agent, 32 parts of curing agent mixture, 15 parts of diluent and 30 parts of toluene solution were mixed and added into a powerful mixer, and stirred for 25 minutes to obtain a transparent solution; wherein the curing agent mixture comprises: nano-silicon dioxide and methyl tetrahydroanhydride, and the mass ratio of nano-silicon dioxide to methyl tetrahydroanhydride is 1:4.5; The transparent solution was placed in a vacuum box for curing. The toluene was completely volatilized before the mixed system reached the gel point. The curing temperature was 190°C and the reaction time was 14 hours to obtain a translucent to transparent modified epoxy resin adhesive sample. Example 2

[0052] This embodiment is based on Example 1, and the specific implementation process of preparing the modified epoxy resin adhesive sample is as follows; 1. The process of preparing modified polydimethylsiloxane is the same as that in Example 1.

[0053] 2. Preparation of modified epoxy resin adhesive 100 parts of epoxy resin, 20 parts of modified polydimethylsiloxane, 20 parts of toughening agent, 32 parts of curing agent mixture, 15 parts of diluent and 30 parts of toluene solution were mixed and added into a powerful mixer, and stirred for 25 minutes to obtain a transparent solution; wherein the curing agent mixture comprises: nano-silicon dioxide and methyl tetrahydroanhydride, and the mass ratio of nano-silicon dioxide to methyl tetrahydroanhydride is 1:4.5; The transparent solution was placed in a vacuum box for curing. The toluene was completely volatilized before the mixed system reached the gel point. The curing temperature was 190°C and the reaction time was 14 hours to obtain a translucent to transparent modified epoxy resin adhesive sample. Example 3

[0054] This embodiment is based on Example 1, and the specific implementation process of preparing the modified epoxy resin adhesive sample is as follows; 1. The process of preparing modified polydimethylsiloxane is the same as that in Example 1.

[0055] 2. Preparation of modified epoxy resin adhesive 100 parts of epoxy resin, 25 parts of modified polydimethylsiloxane, 20 parts of toughening agent, 32 parts of curing agent mixture, 15 parts of diluent and 30 parts of toluene solution were mixed and added into a powerful mixer, and stirred for 25 minutes to obtain a transparent solution; wherein the curing agent mixture comprises: nano-silicon dioxide and methyl tetrahydroanhydride, and the mass ratio of nano-silicon dioxide to methyl tetrahydroanhydride is 1:4.5; The transparent solution was placed in a vacuum box for curing. The toluene was completely volatilized before the mixed system reached the gel point. The curing temperature was 190°C and the reaction time was 14 hours to obtain a translucent to transparent modified epoxy resin adhesive sample. Example 4

[0056] This embodiment is based on Example 1, and the specific implementation process of preparing the modified epoxy resin adhesive sample is as follows; 1. The process of preparing modified polydimethylsiloxane is the same as that in Example 1.

[0057] 2. Preparation of modified epoxy resin adhesive 100 parts of epoxy resin, 10 parts of modified polydimethylsiloxane, 20 parts of toughening agent, 32 parts of curing agent mixture, 15 parts of diluent and 30 parts of toluene solution were mixed and added into a powerful mixer, and stirred for 25 minutes to obtain a transparent solution; wherein the curing agent mixture comprises: nano-silicon dioxide and methyl tetrahydroanhydride, and the mass ratio of nano-silicon dioxide to methyl tetrahydroanhydride is 1:4.5; The transparent solution was placed in a vacuum box for curing. The toluene was completely volatilized before the mixed system reached the gel point. The curing temperature was 190°C and the reaction time was 14 hours to obtain a translucent to transparent modified epoxy resin adhesive sample. Example 5

[0058] This embodiment is based on Example 1, and the specific implementation process of preparing the modified epoxy resin adhesive sample is as follows; 1. The process of preparing modified polydimethylsiloxane is the same as that in Example 1.

[0059] 2. Preparation of modified epoxy resin adhesive 100 parts of epoxy resin, 35 parts of modified polydimethylsiloxane, 20 parts of toughening agent, 32 parts of curing agent mixture, 15 parts of diluent and 30 parts of toluene solution were mixed and added into a powerful mixer, and stirred for 25 minutes to obtain a transparent solution; wherein the curing agent mixture comprises: nano-silicon dioxide and methyl tetrahydroanhydride, and the mass ratio of nano-silicon dioxide to methyl tetrahydroanhydride is 1:4.5; The transparent solution was placed in a vacuum box for curing. The toluene was completely volatilized before the mixed system reached the gel point. The curing temperature was 190°C and the reaction time was 14 hours to obtain a translucent to transparent modified epoxy resin adhesive sample. Example 6

[0060] This embodiment is based on Example 1, and the specific implementation process of preparing the modified epoxy resin adhesive sample is as follows; 1. The process of preparing modified polydimethylsiloxane is the same as that in Example 1.

[0061] 2. Preparation of modified epoxy resin adhesive 100 parts of epoxy resin, 20 parts of modified polydimethylsiloxane, 20 parts of toughening agent, 40 parts of curing agent mixture, 15 parts of diluent and 30 parts of toluene solution were mixed and added into a powerful mixer, and stirred for 25 minutes to obtain a transparent solution; wherein the curing agent mixture comprises: nano-silicon dioxide and methyl tetrahydroanhydride, and the mass ratio of nano-silicon dioxide to methyl tetrahydroanhydride is 1:4.5; The transparent solution was placed in a vacuum box for curing. The toluene was completely volatilized before the mixed system reached the gel point. The curing temperature was 190°C and the reaction time was 14 hours to obtain a translucent to transparent modified epoxy resin adhesive sample. Example 7

[0062] This embodiment is based on Example 1, and the specific implementation process of preparing the modified epoxy resin adhesive sample is as follows; 1. The process of preparing modified polydimethylsiloxane is the same as that in Example 1.

[0063] 2. Preparation of modified epoxy resin adhesive 100 parts of epoxy resin, 20 parts of modified polydimethylsiloxane, 20 parts of toughening agent, 20 parts of curing agent mixture, 15 parts of diluent and 30 parts of toluene solution were mixed and added into a powerful mixer, and stirred for 25 minutes to obtain a transparent solution; wherein the curing agent mixture comprises: nano-silicon dioxide and methyl tetrahydroanhydride, and the mass ratio of nano-silicon dioxide to methyl tetrahydroanhydride is 1:4.5; The transparent solution was placed in a vacuum box for curing. The toluene was completely volatilized before the mixed system reached the gel point. The curing temperature was 190°C and the reaction time was 14 hours to obtain a translucent to transparent modified epoxy resin adhesive sample. Example 8

[0064] This embodiment is based on Example 1, and the specific implementation process of preparing the modified epoxy resin adhesive sample is as follows; 1. The process of preparing modified polydimethylsiloxane is the same as that in Example 1.

[0065] 2. Preparation of modified epoxy resin adhesive 100 parts of epoxy resin, 20 parts of modified polydimethylsiloxane, 20 parts of toughening agent, 32 parts of curing agent mixture, 15 parts of diluent and 30 parts of toluene solution were mixed and added into a powerful mixer, and stirred for 25 minutes to obtain a transparent solution; wherein the curing agent mixture comprises: nano-silicon dioxide and methyl tetrahydroanhydride, and the mass ratio of nano-silicon dioxide to methyl tetrahydroanhydride is 1:6; The transparent solution was placed in a vacuum box for curing. The toluene was completely volatilized before the mixed system reached the gel point. The curing temperature was 190°C and the reaction time was 14 hours to obtain a translucent to transparent modified epoxy resin adhesive sample. Example 9

[0066] This embodiment is based on Example 1, and the specific implementation process of preparing the modified epoxy resin adhesive sample is as follows; 1. The process of preparing modified polydimethylsiloxane is the same as that in Example 1.

[0067] 2. Preparation of modified epoxy resin adhesive 100 parts of epoxy resin, 20 parts of modified polydimethylsiloxane, 20 parts of toughening agent, 32 parts of curing agent mixture, 15 parts of diluent and 30 parts of toluene solution were mixed and added into a powerful mixer, and stirred for 25 minutes to obtain a transparent solution; wherein the curing agent mixture comprises: nano-silicon dioxide and methyl tetrahydroanhydride, and the mass ratio of nano-silicon dioxide to methyl tetrahydroanhydride is 1:3; The transparent solution was placed in a vacuum box for curing. The toluene was completely volatilized before the mixed system reached the gel point. The curing temperature was 190°C and the reaction time was 14 hours to obtain a translucent to transparent modified epoxy resin adhesive sample.

[0068] The modified epoxy resin adhesive samples prepared in the above embodiments 1 to 10 were subjected to shear strength tests and impact strength tests according to GB / T7124-2008 and GB / T2567-2008, respectively; at the same time, the VOC content test and the glue fluidity test were carried out according to the national standards GB / 33372-2020 and GB / T31113-2014, wherein the glue fluidity was tested using the glue applicator method, and the test results are shown in Table 1 below.

[0069] Table 1. Adhesive sample performance test

[0070] As can be seen from Table 1, the adhesive samples prepared in Examples 1, 2, 3 and 6 include, by weight: 100 parts of epoxy resin, 15-25 parts of modified polydimethylsiloxane, 15-25 parts of toughening agent, 32-40 parts of curing agent mixture and 10-15 parts of diluent. Among them, the mass ratio of nano-silicon dioxide to methyl tetrahydroanhydride in the curing agent mixture is in the range of 1:4.1 to 5. It performs well in the tests of mechanical properties, VOC content and adhesive fluidity. Among them, the VOC content is lower than 300g / L, indicating that the structure of the modified epoxy resin adhesive prepared by the present invention can effectively reduce the escape of harmful gases during the curing process.

[0071] The poor performance of Examples 7 and 9 in mechanical property testing is due to the small amount of methyl tetrahydroanhydride added as a curing agent. In Example 5, due to the excessive amount of modified polydimethylsiloxane added, agglomeration occurred. Due to the large molecular weight of polydimethylsiloxane and the occurrence of agglomeration, its compatibility with epoxy resin is poor, resulting in the cross-linked network formed by epoxy resin and polydimethylsiloxane, which will restrict the movement of the epoxy resin molecular chain, resulting in insufficient fluidity of the modified epoxy resin adhesive. In Example 8, due to the large amount of methyl tetrahydroanhydride added as a curing agent, the fluidity is insufficient, making it difficult to apply the glue evenly.

[0072] The present invention also provides a method for applying medical sealant, comprising the following steps: Step S1, grab the catheter and move it to a designated position of the clamp 220 for fixation, and after fixation, the tube opening of the catheter is in a vertical state with the tube facing upward; Step S2, the glue dispensing roller 320 moves downward and is sleeved on the upper end of the catheter, and the inner wall of the glue dispensing roller 320 is in contact with the outer wall of the catheter orifice; Step S3, controlling the catheter to rotate uniformly along its axis at a rotation rate of 50 to 60 RPM / min; Step S4, the glue dispensing roller 320 discharges glue, controls the sealant temperature to be 35-40° C., and the glue discharge volume to be 5-6 ml / min. After the glue discharge continues for 5-8 seconds, the glue coating is completed.

[0073] The present invention provides a method for coating medical sealant. By controlling the uniform rotation of the catheter along its axis and the precise dispensing of the glue at a fixed position of the glue dispensing roller 320, it can be ensured that the sealant is evenly distributed on the outer wall of the catheter orifice. The modified epoxy resin adhesive of the present invention is used, which not only reduces the escape of slightly toxic gas during the curing process of the sealant, but also avoids the problem of uneven coating thickness caused by uneven flow.

[0074] Below, each step is described in detail.

[0075] In step S1, a mechanical gripper is used to grab the catheter from a storage box or a conveyor belt, and is transferred to the middle of two clamping parts of the clamp 220 for fixation. After fixation, the tube mouth of the catheter is vertically upward, thereby realizing automatic loading of the catheter.

[0076] In step S2, the slide is driven by the driving unit, and then the glue dispensing roller 320 is driven to move downward, so that the glue dispensing roller 320 is sleeved on the upper end of the catheter, and the inner wall of the glue dispensing roller 320 is fitted with the outer wall of the catheter tube mouth. The sealant flowing out through the several glue outlets 322 on the glue dispensing roller 320 can be coated on the outer wall of the catheter tube mouth.

[0077] In step S3, the catheter is controlled to rotate uniformly along its axis at a rotation rate of 50 to 60 RPM / min.

[0078] In step S4, the glue dispensing roller 320 discharges glue, so that the sealant flowing out of the plurality of glue outlets 322 flows downward under the action of gravity, and the position of the conduit wall corresponding to the glue outlet 322 at each time point is different, and the sealant is evenly applied in the horizontal and vertical directions. In addition, the sealant temperature is controlled at 35-40°C to ensure the fluidity of the sealant. Within the glue dispensing time of 5-8s, in conjunction with the rotation rate of the conduit, a fixed amount of glue can be evenly applied to the outer wall of the conduit orifice, and excessive overflow of the sealant is reduced, resulting in glue residue at an unnecessary position on the outer wall of the conduit orifice, which is difficult to clean up later.

[0079] Furthermore, after the glue coating is completed, the glue roller 320 moves upward, and the catheter is controlled to continue to rotate for 5 to 10 seconds, and then the catheter is removed and connected to the urine collection bag interface. After the glue roller 320 moves upward, it is separated from the catheter, and a glue mass will be generated on the outer wall of the catheter tube mouth at the moment when the glue is pulled off. At this time, the catheter continues to rotate, and the glue mass will gradually spread out.

[0080] Based on a medical sealant coating method of the present invention, multiple embodiments are provided below to verify the influence of the rotation rate and sealant temperature control on the coating effect during the coating process. Example 10

[0081] This embodiment is based on a method for applying medical sealant to a PVC catheter with an inner diameter of 6 mm and an outer diameter of 8 mm. The specific implementation steps are as follows: 1. Grab the catheter and move it to the designated position of the fixture 220 for fixation. After fixation, the tube opening of the catheter is in a vertical position upwards; 2. The glue roller 320 moves downward and is sleeved on the upper end of the catheter, and the inner wall of the glue roller 320 fits with the outer wall of the catheter orifice. The length of the catheter in the glue roller 320 is 18 mm. 3. Control the catheter to rotate uniformly along its axis at a rate of 50 RPM / min; 4. The glue dispensing roller 320 discharges glue, and the sealant temperature is controlled to be 35°C, the glue output is 6ml / min, and the glue coating is completed after the glue is continuously discharged for 6s. Embodiment 11

[0082] This embodiment is based on Embodiment 10, and glue is applied to a PVC catheter with an inner diameter of 6 mm and an outer diameter of 8 mm, with the difference being that the rotation rate of the catheter is 60 RPM / min. Example 12

[0083] This embodiment is based on Embodiment 10, and glue is applied to a PVC catheter with an inner diameter of 6 mm and an outer diameter of 8 mm, except that: the temperature of the sealant is controlled at 40°C. Example 13

[0084] This embodiment is based on Embodiment 10, and glue is applied to a PVC catheter with an inner diameter of 6 mm and an outer diameter of 8 mm. The difference is that the rotation rate of the catheter is 40 RPM / min. Embodiment 14

[0085] This embodiment is based on Embodiment 10, and glue is applied to a PVC catheter with an inner diameter of 6 mm and an outer diameter of 8 mm. The difference is that the rotation rate of the catheter is 30 RPM / min. Embodiment 15

[0086] This embodiment is based on Embodiment 10, and glue is applied to a PVC catheter with an inner diameter of 6 mm and an outer diameter of 8 mm. The difference is that the rotation rate of the catheter is 70 RPM / min. Example 16

[0087] This embodiment is based on Embodiment 10, and glue is applied to a PVC catheter with an inner diameter of 6 mm and an outer diameter of 8 mm. The difference is that the temperature of the sealant is controlled to be 25°C. Embodiment 17

[0088] This embodiment is based on Embodiment 10, and glue is applied to a PVC catheter with an inner diameter of 6 mm and an outer diameter of 8 mm, except that the temperature of the sealant is controlled at 50°C.

[0089] The glue coating effect on the outer wall of the catheter tube mouth was observed, and the main observation points were whether there were glue faults, glue gaps and glue overflow problems. Glue overflow means that after the glue coating is completed, the glue on the outer wall of the catheter tube mouth exceeds 18mm of the glue coating area, that is, the results are shown in Table 2.

[0090] Table 2. Gluing effect

[0091] By comparing the data of Examples 10-17, it is found that the fluidity of the sealant increases with the increase of temperature and rotation speed. Under the condition of ensuring the amount of glue applied, the overflow of the glue is more serious, and the gap of the glue caused by the overflow will affect the sealed connection between the catheter and the urine collection bag. In Example 14, the rotation rate of the catheter is low. During the 6s glue application time, the glue has no chance to be coated on all positions of the outer wall of the catheter tube, resulting in more gaps. The sealant temperature of Example 16 is 25°C, resulting in insufficient fluidity of the sealant. During the 6s glue application time, the glue from the upper glue outlet 322 can no longer flow to the middle layer during the rotation process, resulting in a fault, that is, the glue layer in this 2mm width is thin, or even no glue.

[0092] The above is based on the ideal embodiment of the present invention. Through the above description, relevant personnel can make various changes and modifications without departing from the technical concept of the present invention. The technical scope of the present invention is not limited to the content in the specification, and the technical scope must be determined according to the scope of the claims.

Claims

1. A medical sealant coating device, comprising: A workbench, a feeding mechanism, a glue rolling mechanism and a glue coating mechanism arranged on the workbench; characterized in that the feeding mechanism is arranged on one side of the glue rolling mechanism; The rubber rolling mechanism comprises: a rotating assembly, and a clamp arranged on the rotating assembly; The rotating assembly is used to drive the fixture to rotate at a constant speed along the central axis of the catheter; the rotating assembly includes: a rotating table arranged on the upper surface of the workbench, and a first servo motor arranged on the lower side of the workbench; the first servo motor drives the rotating table to rotate through a gear set; the gear set includes: a driving gear and a driven gear in meshing connection; the surface of the rotating disk is provided with a catheter groove that penetrates the rotating disk, the workbench and the driven gear, and the catheter groove, the rotating disk and the driven gear are arranged to be concentric, and the inner diameter of the catheter groove is much larger than the diameter of the catheter; The clamp is used to clamp the catheter and control the tube mouth of the catheter to be in a vertical state upward; the clamp comprises: electric push rods distributed oppositely on both sides of the catheter groove, and a clamping member arranged at the movable end of the electric push rod; the clamping member comprises: a connecting part fixed to the movable end of the electric push rod, a retaining part arranged on one side of the connecting part close to the catheter groove, the retaining part is semi-cylindrical, and the retaining parts on both sides are butt-jointed and combined into a cylinder, and the inner diameter of the cylinder matches the outer diameter of the catheter; The feeding mechanism is used to grab the catheter and move it to a designated position of the fixture; The glue coating mechanism is arranged above the glue rolling mechanism; The glue coating mechanism includes: a displacement component, and a glue dispensing roller arranged on one side of the displacement component; the glue dispensing roller is in the shape of a vertically arranged hollow cylinder, and the displacement component drives the glue dispensing roller to move downward, so that the inner wall of the glue dispensing roller fits with the outer wall of the catheter orifice, and sealant is applied thereto; The sealant is a modified epoxy resin adhesive.

2. A medical sealant coating device according to claim 1, characterized in that: The displacement assembly includes: a guide rail arranged on the upper surface of the workbench, a slide arranged on the guide rail, and a driving unit for controlling the movement of the slide; wherein the guide rail is arranged vertically, and the slide moves vertically on the guide rail, and the glue dispensing roller is arranged on the surface of the slide.

3. A medical sealant coating device according to claim 1, characterized in that: The lower end surface of the glue dispensing roller is grooved so that the glue dispensing roller is sleeved on the upper end of the conduit. The glue dispensing roller includes: a glue flow cavity, and a plurality of glue outlets opened on the side wall of the glue flow cavity; the plurality of glue outlets are divided into an upper glue outlet and a middle glue outlet according to the height of the inner wall of the glue dispensing roller.

4. A medical sealant coating device according to claim 1, characterized in that: A vertical support rod is arranged inside the dispensing roller. The support rod is a cylinder and is arranged at the center of the dispensing roller. In addition, the diameter of the support rod is smaller than the inner diameter of the catheter.

5. The medical sealant coating device according to claim 1, characterized in that: The modified epoxy resin adhesive comprises, by weight: 100 parts of epoxy resin, 15-20 parts of modified polydimethylsiloxane, 15-25 parts of toughening agent, 32-40 parts of curing agent mixture and 10-15 parts of diluent.

6. A medical sealant coating device according to claim 5, characterized in that: The preparation method of the modified polydimethylsiloxane comprises the following steps: Step 1, mixing and stirring vinyl-polydimethylsiloxane, hydrogen-polydimethylsiloxane and platinum catalyst evenly; wherein the mass ratio of vinyl-polydimethylsiloxane, hydrogen-polydimethylsiloxane and platinum catalyst is 1:1.1-1.5:0.02-0.05; Step 2: react the mixture at 170° C. to 210° C. for 3 to 5 hours to obtain modified polydimethylsiloxane.

7. The medical sealant coating device according to claim 5, characterized in that: The preparation method of the modified epoxy resin adhesive comprises the following steps: Step 1: Mix epoxy resin, modified polydimethylsiloxane, toughening agent, curing agent mixture, diluent and toluene solution according to weight, add them into a powerful mixer, and stir for 20 to 30 minutes to obtain a transparent solution; Step 2: Place the transparent solution in a vacuum box for curing. The toluene is completely volatilized before the mixed system reaches the gel point. The curing temperature is 170°C to 210°C. The reaction time is 12 to 16 hours to obtain a translucent to transparent modified epoxy resin adhesive product.

8. A method for applying medical sealant, based on a medical sealant applying device according to any one of claims 1 to 7, characterized in that: The following steps are involved: Step S1, grab the catheter and move it to a designated position of the clamp for fixing, after which the catheter is fixed with the tube opening facing upwards in a vertical state; Step S2, the glue dispensing roller moves downward and is sleeved on the upper end of the catheter, and the inner wall of the glue dispensing roller is in contact with the outer wall of the catheter orifice; Step S3, controlling the catheter to rotate at a constant speed along its axis; Step S4, the glue dispensing roller discharges glue, the temperature of the sealant is controlled at 35-40° C., the glue discharge amount is 5-6 ml / min, and the glue is continuously discharged for 5-8 seconds to complete the glue coating.

9. A method for applying medical sealant according to claim 8, characterized in that: In S3, the catheter rotation rate is 50-60 RPM / min.

10. A method for applying medical sealant according to claim 8, characterized in that: Also includes: After the glue coating is completed, the glue dispensing roller moves up, and the catheter is controlled to continue rotating for 5 to 10 seconds, and then the catheter is removed and connected to the urine collection bag interface.

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