Food-grade bactericide and preparation method thereof

Abstract

The invention provides a food-grade bactericide and a preparation method thereof, and the bactericide is mainly prepared from the following raw materials in parts by mass: 8-10 parts of DBNPA, 5-10 parts of glycerol, 3-8 parts of polyhexamethylene guanidine, 3-5 parts of glutaraldehyde, 5-15 parts of ACS, 1-3 parts of a defoaming agent and 20-30 parts of deionized water. The food-grade bactericide disclosed by the invention not only can effectively sterilize, but also can meet the requirements of food safety and environmental friendliness.

Description

Technical Field

[0001] The invention belongs to the technical field of bactericides, and in particular to a food-grade bactericide suitable for a reverse osmosis process. Background Art

[0002] In liquid food and many industries with extremely high requirements for water quality, reverse osmosis technology, as an efficient water treatment technology, is widely used in the process of water purification to ensure the safety and quality of the final product. The reverse osmosis system can effectively remove impurities such as soluble solids, organic matter, bacteria, viruses and most microorganisms in water through the principle of selective permeability of semi-permeable membranes, thereby providing high-quality purified water. However, as the system runs longer, pollutants are easily accumulated on the membrane surface, causing biological pollution, such as the growth of bacteria, viruses and microorganisms, which will not only reduce the flux and water quality of the reverse osmosis membrane, but may also cause irreversible damage to the system.

[0003] Current countermeasures on the market include regular chemical cleaning of the reverse osmosis system to remove contaminants on the membrane. However, frequent chemical cleaning not only increases operating costs and time, but may also pollute the environment due to the use of improper cleaning agents. At the same time, certain cleaning agent residues may also pose a potential threat to subsequent water treatment effects and food safety. In addition, although existing fungicides can inhibit the growth of microorganisms to a certain extent, they often have problems such as low sterilization efficiency, long action time, and great impact on the environment and operator safety. It is difficult to meet the high standards and environmental protection requirements of food-grade water quality. For this reason, there is an urgent need for a fungicide on the market to solve the above problems.

[0004] In view of this, the present invention is proposed. Summary of the invention

[0005] The first purpose of the present invention is to provide a food-grade bactericide, which not only has high-efficiency bactericidal performance and can remove viruses, bacteria and microorganisms in the reverse osmosis system, but also reduces the cleaning frequency of the reverse osmosis system, and strictly follows food safety standards to ensure that the water quality of the reverse osmosis system reaches food-grade standards, thereby meeting the safety and hygiene requirements in the food production and processing process.

[0006] The second object of the present invention is to provide a method for preparing the above-mentioned food-grade fungicide, which is simple to operate, can achieve rapid product preparation, has a mild operation process, and does not produce harmful substances in the entire preparation process, thus achieving a green and environmentally friendly production process. At the same time, it is ensured that the product will not have adverse effects on operators and the use site during use.

[0007] In order to achieve the above-mentioned purpose of the present invention, the following technical solutions are particularly adopted: The invention provides a food-grade bactericide, which is mainly prepared from the following raw materials: by weight, 8-10 parts of DBNPA, 5-10 parts of glycerol, 3-8 parts of polyhexamethylene guanidine, 3-5 parts of glutaraldehyde, 5-15 parts of ACS, 1-3 parts of a defoaming agent and 20-30 parts of deionized water.

[0008] Preferably, as a further implementable scheme, calculated by weight, DBNPA 8.5-9.5 parts, glycerol 6-9 parts, polyhexamethylene guanidine 4-7 parts, glutaraldehyde 3.5-4.5 parts, ACS 8-12 parts, defoamer 1.5-2.5 parts, deionized water 21-29 parts.

[0009] Preferably, as a further feasible embodiment, calculated by weight, DBNPA 9 parts, glycerol 8 parts, polyhexamethylene guanidine 6 parts, glutaraldehyde 4 parts, ACS 10 parts, defoaming agent 2 parts, deionized water 25 parts.

[0010] In the above materials, DBNPA is called 2,2-dibromo-3-nitrilopropionamide, which is a bactericide and algaecide, polyhexamethylene guanidine has the ability to kill bacteria, and ACS is called acidic calcium sulfate, which is a bactericidal and preservative product. Therefore, in the bactericide of the present invention, BDNPA, polyhexamethylene guanidine and ACS are the main bactericidal components. Although the effects of the three are different, they can penetrate the cell membrane of microorganisms, destroy their internal structure and metabolic process, and the penetration speed is fast; the three work synergistically to achieve the effect of rapid killing. At the same time, it shows good inhibitory effects on various types of bacteria, viruses and fungi, so that the water quality treated in the reverse osmosis system is free of microbial contamination.

[0011] BDNPA, polyhexamethylene guanidine and ACS, these bactericidal components, can not only sterilize, but also continuously inhibit the regeneration and reproduction of various bacteria, viruses and microorganisms for a period of time, thereby extending the duration of the bactericidal effect and reducing the frequency of repeated sterilization. Thus, the frequency of use of the bactericide of the present invention is reduced, the cleanliness and sanitation of the reverse osmosis system can be maintained for a long time, and the cost and time of maintaining the reverse osmosis system are reduced.

[0012] Among the above raw materials, propylene glycol, glutaraldehyde, defoaming agent and deionized water as auxiliary ingredients are all non-toxic or low-toxic substances, which will not cause harm to the human body and the environment during use. Moreover, these ingredients are easily degraded and will not accumulate in the environment to cause pollution.

[0013] Among the above raw materials, the defoaming agent can effectively eliminate the foam generated by the fungicide during use, so that the fungicide can better contact with the microorganisms, avoid affecting the sterilization effect, and improve the sterilization effect.

[0014] The components of all the above raw materials have been measured to ensure rapid sterilization without causing unnecessary harm to operators and the environment.

[0015] In addition to providing a formula of a food-grade fungicide, the present invention also provides a method for preparing the food-grade fungicide, comprising the following steps: Add DBNPA and glycerol into a reaction kettle and stir and heat; Then add polyhexamethylene guanidine and add glutaraldehyde while stirring; Then add ACS and defoamer and continue stirring, and finally add deionized water.

[0016] Preferably, DBNPA and glycerol are added to a reaction kettle and stirred and heated. The stirring time is 25-35 minutes and the heating temperature is 55° C.-65° C.

[0017] Preferably, polyhexamethylene guanidine is added and glutaraldehyde is added during stirring, and the stirring time is continued for 1.5-2.5 hours.

[0018] Preferably, in the step of adding ACS and defoaming agent and continuing stirring, the stirring time is 25-35 minutes.

[0019] In the present invention, by limiting each operating parameter in the preparation method, the quality of the prepared food-grade bactericide is improved, so that it is not decomposed and deteriorated by external factors, ensuring that the food-grade bactericide still maintains an excellent bactericidal effect during use.

[0020] Compared with the prior art, the present invention has the following beneficial effects: (1) The food-grade bactericide of the present invention uses BDNPA, polyhexamethylene guanidine and ACS as the main bactericidal components. Through the synergistic effect between them, it has an excellent bactericidal effect in a short time, and can significantly reduce the pollution of various bacteria, viruses and microorganisms in the reverse osmosis system, thereby extending the cleaning cycle of the reverse osmosis system, reducing the maintenance time and cost of the reverse osmosis system, and improving the production efficiency of the reverse osmosis system. By reducing the erosion and damage of various bacteria, viruses and microorganisms to the reverse osmosis system, the service life of the reverse osmosis system can be extended, the replacement of components can be reduced, and the maintenance cost of the reverse osmosis system can be further reduced.

[0021] (2) The food-grade bactericide of the present invention keeps the reverse osmosis system clean and running efficiently by reducing the pollution of various bacteria, viruses and microorganisms to the reverse osmosis system. This ensures that the water quality of many industries that use reverse osmosis systems for liquid food and have high requirements for water quality meets food-grade standards after treatment, thereby ensuring the safety and quality of liquid food.

[0022] (3) The pollution of the reverse osmosis system by various bacteria, viruses and microorganisms reduces its efficiency. The food-grade bactericide of the present invention can effectively reduce the pollution, thereby improving the performance of the reverse osmosis system as a whole and improving the operating efficiency of the system.

[0023] (4) The preparation method of the present invention is simple and will not cause harm to the operator's body and the environment. At the same time, it improves the preparation efficiency and ensures the stability of the product. DETAILED DESCRIPTION

[0024] The technical scheme of the present invention will be clearly and completely described below in conjunction with specific embodiments, but it will be appreciated by those skilled in the art that the following described embodiments are some embodiments of the present invention, rather than all embodiments, and are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative work, all belong to the scope of protection of the present invention. If specific conditions are not indicated in the embodiments, they are carried out according to normal conditions or conditions recommended by the manufacturer. If the manufacturer is not indicated in the reagents or instruments used, they are all conventional products that can be purchased commercially.

[0025] Example 1 The specific preparation process of food-grade fungicide is carried out according to the following steps: 8 kg DBNPA and 5 kg propylene glycol were added to the reactor, heated to 55 °C with stirring, and stirred for 30 min until the mixture was uniform; Then, 3 kg of polyhexamethylene guanidine was added to the reaction kettle and stirred. During the stirring process, 3 kg of glutaraldehyde was added to the reaction kettle and the stirring was continued for 2 h. Then add 5kg ACS and 1kg defoamer into the reactor and continue stirring for 30min; Finally, add 20 kg of deionized water into the reactor to obtain the product.

[0026] Example 2 The specific preparation process of food-grade fungicide is carried out according to the following steps: Take 10kg DBNPA and 10kg propylene glycol and add them into the reactor, stir and heat to 58°C, and stir for 30min until the mixture is evenly mixed; Then, 8 kg of polyhexamethylene guanidine was added to the reactor and stirred. During the stirring process, 5 kg of glutaraldehyde was added to the reactor and the stirring was continued for 2 h. Then add 15kg ACS and 3kg defoamer into the reactor and continue stirring for 30min; Finally, 30 kg of deionized water was added into the reactor to obtain the product.

[0027] Example 3 The specific preparation process of food-grade fungicide is carried out according to the following steps: Add 9 kg DBNPA and 8 kg propylene glycol into a reactor, heat to 60 °C with stirring, and stir for 30 min until the mixture is uniform. Then, 6 kg of polyhexamethylene guanidine was added to the reactor and stirred. During the stirring process, 4 kg of glutaraldehyde was added to the reactor and the stirring was continued for 2 h. Then add 10kg ACS and 2kg defoamer into the reactor and continue stirring for 30min; Finally, 25 kg of deionized water was added into the reactor to obtain the product.

[0028] Example 4 The specific preparation process of food-grade fungicide is carried out according to the following steps: 8.5 kg DBNPA and 6 kg propylene glycol were added to the reactor, heated to 57 °C with stirring, and stirred for 30 min until the mixture was uniform; Then, 4 kg of polyhexamethylene guanidine was added to the reactor and stirred. During the stirring process, 3.5 kg of glutaraldehyde was added to the reactor and the stirring was continued for 2 h. Then add 8kg ACS and 1.5kg defoamer into the reactor and continue stirring for 30min; Finally, 21 kg of deionized water was added into the reactor to obtain the product.

[0029] Example 5 The specific preparation process of food-grade fungicide is carried out according to the following steps: Add 9.5 kg DBNPA and 9 kg propylene glycol into the reactor, stir and heat to 62 °C, and stir for 30 min until the mixture is uniform. Then, 7 kg of polyhexamethylene guanidine was added to the reactor and stirred. During the stirring process, 4.5 kg of glutaraldehyde was added to the reactor and the stirring was continued for 2 h. Then add 12 kg ACS and 2.5 kg defoamer into the reactor and continue stirring for 30 min; Finally, 29 kg of deionized water was added into the reactor to obtain the product.

[0030] Example 6 The specific implementation method is consistent with Example 3, except that the mass fraction of polyhexamethylene guanidine is changed to 4 kg.

[0031] Example 7 The specific implementation method is consistent with Example 3, except that the mass fraction of polyhexamethylene guanidine is changed to 7 kg.

[0032] Example 8 The specific implementation method is consistent with Example 3, except that the mass fraction of ACS is changed to 13 kg.

[0033] Comparative Example 1 The specific implementation method is consistent with Example 3, except that the mass fraction of glutaraldehyde is changed to 1 kg.

[0034] Comparative Example 2 The specific implementation method is consistent with Example 3, except that the mass fraction of DBNPA is changed to 3 kg.

[0035] Comparative Example 3 The specific implementation method is consistent with Example 3, except that the mass fraction of DBNPA is changed to 22 kg.

[0036] Comparative Example 4 Choose common disinfectants on the market, whose main ingredients are chloride, hypochlorous acid and hydrogen peroxide.

[0037] Experimental Example 1 The food-grade bactericide of the present invention was evaluated according to the actual bactericidal effect of the on-site reverse osmosis system, and the evaluation method was performed in accordance with HG / T 3657-2017. The experimental results are shown in Table 1.

[0038] Table 1: Experimental results

[0039] Based on the above data, the following conclusions can be drawn: By comprehensively evaluating the practical application of the bactericides of Examples 1-8 and Comparative Examples 1-4 in the reverse osmosis system, it can be seen that the food-grade bactericide of the present invention exhibits excellent bactericidal performance and stability. Through the observation of Examples 1-8, the active matter content and killing rate of the bactericide are adjusted with the ratio of the key components of DBNPA, polyhexamethylene guanidine, and ACS in the preparation conditions. It can be seen that in Example 3, the active content of the food-grade bactericide reaches 99.7%, and no sticky mud is produced in the scale sample analysis within a 6-month cleaning cycle. It can be seen that the ratio of each component in the food-grade bactericide of the present invention and the preparation parameters corresponding to the ratio will affect the bactericidal effect through the comprehensive effect of mutual coordination, and the best bactericidal effect can be obtained by selecting the optimal ratio relationship.

[0040] From the perspective of active matter content, the active matter content of the embodiments is between 2.3% and 2.6%, indicating that the composition ratio of the food-grade fungicide of the present invention is reasonable and can effectively ensure the bactericidal effect. In contrast, although the active matter content in the comparative example is close to that in the embodiment, it is still slightly lower overall. Although the active matter content of the special comparative example 4 is consistent with that of the optimal embodiment 3 of the present invention, the killing rate is significantly lower than that of the embodiment 3, which proves the superior bactericidal performance of the food-grade fungicide of the present invention.

[0041] In terms of killing rate, the killing rates of Examples 1 to 8 all reached more than 99%, and Example 3 was as high as 99.7%, which fully demonstrated that the food-grade fungicide of the present invention has a strong bactericidal ability. The killing rates in the comparative examples are generally low, especially in Comparative Example 4, which uses a fungicide sold on the market, and the killing rate is only 88.5% at a dosing concentration of 30 mg / l, and even at a dosing concentration of 50 mg / l, it only reaches 91.2%, which is significantly lower than the level of the examples, further illustrating that the bactericidal effect of the food-grade fungicide of the present invention is better than that of fungicides sold on the market.

[0042] From the perspective of the cleaning cycle, the cleaning cycles of Examples 1 to 8 are all 6 months, indicating that the actual application of the food-grade bactericide of the present invention in the reverse osmosis system can maintain its stable bactericidal effect for a long time, reduce the frequency of cleaning, and greatly reduce the maintenance cost and time of the reverse osmosis system. The cleaning cycle in the comparative example is shorter than that in the embodiment, especially the cleaning cycle of Comparative Example 4 is only 4 months, indicating that the existing bactericides on the market are more likely to fail in the actual application process of the reverse osmosis system.

[0043] In terms of scale sample analysis, the scale sample analysis results of Examples 1 to 8 all showed no sludge, indicating that the food-grade bactericide of the present invention can effectively prevent the generation and accumulation of sludge in the reverse osmosis system. In contrast, a small amount of sludge or even sludge generally appeared in the comparative examples, and the generation of sludge would cause membrane contamination of the reverse osmosis system, reduce the water production, and also reduce the product water quality. In particular, the experimental data of Example 3 and Comparative Examples 2-3 show that the important components of the food-grade bactericide of the present invention cannot achieve the best bactericidal effect if too much or too little is added, but it is necessary to control its important components in an optimal range, so that the compatibility and complementarity of each component can be good while retaining the advantages of each component, and play a synergistic role.

[0044] Next, from the perspective of dosing concentration, the embodiment and the comparative example were compared at a dosing concentration of 30 mg / l. It can be seen that under the same concentration, the bactericidal effect of the embodiment is significantly better than that of the comparative example; although the dosing concentration of 50 mg / l was also tested in Comparative Example 4, it can be seen that even if the concentration of the bactericide sold on the market is increased, it cannot achieve the bactericidal effect of 30 mg / l of the food-grade bactericide of the present invention. Considering the cost and environmental performance of the actual application in the reverse osmosis system, the superior bactericidal performance of the food-grade bactericide of the present invention in practical applications is further demonstrated.

[0045] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A food-grade bactericide, characterized in that: The invention is mainly prepared from the following raw materials by weight: 8-10 parts of DBNPA, 5-10 parts of glycerol, 3-8 parts of polyhexamethylene guanidine, 3-5 parts of glutaraldehyde, 1-3 parts of defoaming agent, 5-15 parts of ACS and 20-30 parts of deionized water.

2. The food-grade bactericide according to claim 1, characterized in that In parts by mass, the ingredients include 8.5-9.5 parts of DBNPA, 6-9 parts of glycerol, 4-7 parts of polyhexamethylene guanidine, 3.5-4.5 parts of glutaraldehyde, 8-12 parts of ACS, 1.5-2.5 parts of defoaming agent, and 21-29 parts of deionized water.

3. The food-grade reverse osmosis bactericide according to claim 1, characterized in that: In parts by mass, DBNPA 9 parts, glycerol 8 parts, polyhexamethylene guanidine 6 parts, glutaraldehyde 4 parts, defoamer 2 parts, ACS 10 parts, and deionized water 25 parts.

4. A method for preparing a food-grade bactericide according to any one of claims 1 to 3, characterized in that: The steps include: DBNPA and glycerol are mixed, stirred and heated; Then add polyhexamethylene guanidine and add glutaraldehyde while stirring; Then add ACS and defoamer and continue stirring, and finally add deionized water.

5. The method for preparing a food-grade bactericide according to claim 4, characterized in that: In the step of mixing, stirring and heating DBNPA and glycerol, the heating temperature is 55° C.-65° C., and the stirring time is 25-35 min.

6. The method for preparing a food-grade bactericide according to claim 4, characterized in that: The step of adding polyhexamethylene guanidine and adding glutaraldehyde during stirring and continuing stirring has a stirring time of 1.5-2.5 hours.

7. The method for preparing a food-grade bactericide according to claim 4, characterized in that: In the step of adding ACS and defoaming agent and continuing stirring, the stirring time is 25-35 minutes.

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