Ablation condition judgment device and method and computer readable storage medium

Abstract

The invention provides an ablation condition judgment device and method and a computer readable storage medium, and relates to the field of medical instruments. The ablation condition judgment device is applied to an ablation device comprising a plurality of ablation electrodes. The ablation condition judgment device comprises a first impedance detection circuit and an ablation condition judgment module, the first impedance detection circuit is connected with the plurality of ablation electrodes and is configured to detect first impedance information between the target ablation electrode pairs; the ablation condition judgment module is connected with the first impedance detection circuit, and the ablation condition judgment module is configured to obtain the first impedance information and judge the current ablation condition based on the first impedance information. The first impedance information between every two ablation electrodes in the ablation area is detected through the first impedance detection circuit, and therefore the real-time performance and accuracy of ablation condition judgment are high. Not only can the damage of non-target tissues caused by excessive ablation be avoided to a great extent, but also the condition of poor ablation effect caused by insufficient ablation time can be avoided.

Description

Technical Field

[0001] The present application relates to the field of medical devices, and in particular, to an ablation situation determination device, method and computer-readable storage medium. Background Art

[0002] In the field of ablation, it is very important to accurately understand the ablation situation. It not only ensures the accuracy of the operation and enables the ablation to act accurately on the target ablation tissue, but also helps doctors dynamically adjust the operation through real-time feedback to avoid excessive or insufficient ablation. In addition, a comprehensive understanding of the ablation process can help prevent complications, such as damage to adjacent healthy tissues, improve the safety and effectiveness of treatment, and provide patients with personalized and optimal treatment plans.

[0003] At present, the understanding of ablation conditions comes from collecting the changes in the loop impedance between the neutral electrode attached to the body surface and the ablation electrode in the target ablation area, and the ablation conditions are understood through the impedance changes.

[0004] However, there is a certain distance between the ablation electrode located in the target ablation area and the neutral electrode on the body surface, and the distance may be inconsistent; on the other hand, different target ablation objects may have tissue and anatomical differences; resulting in different electrode setting positions or different patients, there may be large differences in impedance values, making it difficult to accurately and real-time grasp the ablation situation. Summary of the invention

[0005] The purpose of the embodiments of the present application is to provide an ablation situation judgment device, method and computer-readable storage medium, wherein the first impedance information between the target ablation electrode pair is detected by a first impedance detection circuit, and the first impedance information is analyzed by an ablation situation judgment module, so that the real-time and accuracy of the ablation situation judgment are high. Real-time and accurate grasp of the ablation situation can not only avoid damage to non-target tissues caused by excessive ablation to a great extent, but also avoid poor ablation effects caused by insufficient ablation time.

[0006] In a first aspect, an embodiment of the present application provides an ablation situation judgment device, which is applied to an ablation device including multiple ablation electrodes, and the ablation situation judgment device includes: a first impedance detection circuit and an ablation situation judgment module; the multiple ablation electrodes are configured to contact the ablation tissue wall and release ablation energy during the ablation process; the first impedance detection circuit is connected to the multiple ablation electrodes and is configured to detect first impedance information between the target ablation electrode pairs; the ablation situation judgment module is connected to the first impedance detection circuit, and the ablation situation judgment module is configured to obtain the first impedance information and judge the current ablation situation based on the first impedance information.

[0007] In the above implementation process, the ablation situation judgment device provided in the embodiment of the present application detects the first impedance information between the target ablation electrode pair through the first impedance detection circuit, and analyzes the first impedance information through the ablation situation judgment module to obtain the current ablation situation. Therefore, the ablation situation judgment device provided in the embodiment of the present application has high real-time and accuracy in judging the ablation situation because the first impedance detection circuit detects the first impedance information between the two ablation electrodes in the ablation area. Real-time and accurate grasp of the ablation situation can not only avoid damage to non-target tissues caused by excessive ablation to a great extent, but also avoid poor ablation effects caused by insufficient ablation time.

[0008] Optionally, in an embodiment of the present application, the first impedance detection circuit includes a first impedance measurement unit and a plurality of first impedance detection switches; each first impedance detection switch is connected to the first impedance measurement unit and an ablation electrode; the first impedance detection switch is configured to constitute a first impedance detection path of the target ablation electrode pair when the corresponding first impedance detection switch of the target ablation electrode pair is closed; the first impedance measurement unit is configured to measure the first impedance information between the target ablation electrode pair.

[0009] In the above implementation process, the first impedance detection circuit in the ablation situation determination device provided by the embodiment of the present application is connected to multiple first impedance detection switches to achieve impedance measurement between two ablation electrodes. In other words, the ablation situation determination device provided by the embodiment of the present application can quickly and flexibly measure the first impedance information between different electrode pairs, and can achieve real-time grasp of the ablation situation of each ablation point in the target ablation area.

[0010] Optionally, in an embodiment of the present application, the first impedance detection switch includes a first end switch and a second end switch; the first end switch connects the first end of the first impedance measurement unit and the target ablation electrode; the second end switch connects the second end of the first impedance measurement unit and the target ablation electrode; the first end switch and the second end switch are configured to form a first impedance detection path for a target ablation electrode pair including a first target ablation electrode and a second target ablation electrode when the first end switch corresponding to the first target ablation electrode and the second end switch corresponding to the second target electrode are closed, or when the second end switch corresponding to the first target ablation electrode and the first end switch corresponding to the second target electrode are closed.

[0011] In the above implementation process, the embodiment of the present application provides an example of a first impedance detection circuit, and provides a first detection scheme for realizing the first impedance information between two ablation electrodes. Each electrode is respectively connected to the two ends of the first impedance detection unit through a switch, and the combination of different ablation electrodes is realized by turning on and off the switch, and the first impedance between two different ablation electrodes is measured. By measuring the first impedance information between the target ablation electrode and other ablation electrodes, the ablation condition of the target ablation point corresponding to the target ablation electrode can be judged; it not only overcomes the inaccuracy and individual differences of the impedance obtained from the ablation electrode to the body surface electrode by the traditional method, but also can accurately and real-time obtain the ablation condition of the target ablation area, ensuring the safety and effectiveness of the smile surgery.

[0012] Optionally, in an embodiment of the present application, the ablation situation judgment device also includes multiple ablation switches and a wall adhesion detection circuit having multiple wall adhesion detection switches; each ablation switch is connected to the wall adhesion detection circuit and an ablation electrode, and the ablation switch is configured to form a wall adhesion detection circuit including the ablation electrode and the wall adhesion detection circuit when the ablation switch and the corresponding wall adhesion detection switch are closed.

[0013] Optionally, in an embodiment of the present application, the wall adhesion detection circuit also includes a neutral electrode and a second impedance measurement unit; the neutral electrode is arranged on the surface of the target ablation object; the first end of the second impedance measurement unit is respectively connected to multiple ablation electrodes through multiple wall adhesion detection switches; the second end of the second impedance measurement unit is connected to the neutral electrode; the second impedance measurement unit is configured to measure the second impedance information between the neutral electrode and the ablation electrode corresponding to the wall adhesion detection switch when the wall adhesion detection switch is closed and the corresponding ablation switch is closed.

[0014] In the above-mentioned implementation process, the ablation situation judgment device provided in the embodiment of the present application is provided with a wall adhesion detection circuit, which can measure the second impedance information between the target ablation electrode and the neutral electrode arranged on the surface of the ablation object. According to the second impedance information, the wall adhesion situation of the target ablation electrode can be judged, so as to achieve effective ablation, and ensure that the first impedance information between the two ablation electrodes is available, which is conducive to accurately grasping the ablation situation of the target ablation area.

[0015] Optionally, in an embodiment of the present application, the first impedance detection switch includes a first switch and a second switch; the first switch connects the first end of the first impedance measurement unit and the first target ablation electrode; the second switch connects the second end of the first impedance measurement unit and the second target ablation electrode; the first switch and the second switch are configured to, when the first switch and the second switch are closed, form a first impedance measurement path including the first target ablation electrode, the second target ablation electrode and the first impedance measurement unit.

[0016] In the above-mentioned implementation process, the structure of the second example diagram of the first impedance detection circuit provided in the embodiment of the present application replaces the correspondence between one ablation point and one ablation electrode with one ablation point and two ablation electrodes; thereby, the implementation architecture of the impedance measurement between two points in the target ablation area to grasp the ablation situation is simpler, and the ablation situation can be grasped efficiently and accurately with a simpler structure.

[0017] Optionally, in an embodiment of the present application, the ablation situation judgment device also includes a temperature detection module; the temperature detection module is connected to the ablation situation judgment module and configured to detect temperature information of the target ablation area; the ablation situation judgment module is also configured to judge the current ablation situation based on the first impedance information and temperature information.

[0018] In the above implementation process, the ablation situation judgment device provided in the embodiment of the present application can provide a more comprehensive ablation situation judgment by adding a temperature detection module to monitor the real-time ablation temperature at a certain depth of the target ablation area in real time, which can be used in combination with the first impedance information. It helps to more accurately monitor and control the ablation process, avoid tissue damage caused by overheating or insufficient ablation caused by too low a temperature, and further improve the safety and efficacy of the operation.

[0019] Optionally, in an embodiment of the present application, the ablation situation judgment module, in the process of judging the current ablation situation based on the first impedance information and the temperature information, is specifically used to: judge whether the decline amplitude of the first impedance information reaches the impedance decline threshold, and / or judge whether the temperature information reaches the temperature threshold and maintains the preset time length; if the decline amplitude of the first impedance information reaches the impedance decline threshold, and / or the temperature information reaches the temperature threshold and maintains the preset time length, it is determined that the ablation end point has been reached.

[0020] In the above-mentioned implementation process, the ablation situation judgment module of the ablation situation judgment device provided in the embodiment of the present application can directly judge whether the ablation end point has been reached by obtaining the decrease amplitude of the first impedance information and / or whether the temperature information of a certain ablation depth reaches the temperature threshold and maintains it for a certain period of time. Otherwise, ablation continues. Therefore, the ablation situation judgment device provided in the embodiment of the present application can analyze the collected data through the ablation situation judgment module to realize efficient and accurate grasp of the ablation situation.

[0021] In the second aspect, an embodiment of the present application provides an ablation endpoint judgment method, which is applied to an ablation situation judgment device, and the ablation situation judgment device includes a first impedance detection circuit and an ablation situation judgment module; the ablation endpoint judgment method includes: obtaining the first impedance information between the target ablation electrode and other ablation electrodes by the first impedance detection circuit; judging by the ablation situation judgment circuit, judging whether the target ablation point corresponding to the target electrode has reached the ablation endpoint according to the impedance information; wherein, the target ablation electrode and other ablation electrodes are attached to the target ablation tissue wall and are used to release ablation energy.

[0022] Optionally, in an embodiment of the present application, the ablation situation judgment module also includes a wall adhesion detection circuit; before obtaining the impedance information between the target ablation electrode and other ablation electrodes, the ablation endpoint judgment method also includes: using the wall adhesion detection circuit to detect the adhesion of the ablation electrodes including the target ablation electrode and other ablation electrodes to the ablation tissue wall.

[0023] Optionally, in an embodiment of the present application, obtaining the first impedance information between the target ablation electrode and other ablation electrodes includes: measuring the impedance information between the target ablation electrode and one other ablation electrode in time-sharing manner until the measurement of the impedance information between the target ablation electrode and all other ablation electrodes is completed; and controlling the ablation electrode for which impedance information measurement has not been performed to output ablation energy.

[0024] In the above implementation process, the ablation endpoint judgment method provided in the embodiment of the present application is based on the change of volume impedance value along the length of the artery collected by the ablation endpoint judgment device, which can better reflect the actual ablation effect of the ablation point. At the same time, an omnidirectional ultrasonic transducer can be set in the center of the catheter to detect the actual ablation temperature within a certain depth in real time, which can intuitively and directly evaluate the degree of nerve damage achieved by ablation and accurately and timely judge the ablation endpoint.

[0025] In a third aspect, an embodiment of the present application provides an electronic device, comprising a memory and a processor, wherein the memory stores program instructions, and when the processor reads and runs the program instructions, it executes the steps in any of the above implementation methods.

[0026] In a fourth aspect, an embodiment of the present application further provides a computer-readable storage medium, wherein the computer-readable storage medium stores computer program instructions, and when the computer program instructions are read and executed by a processor, the steps in any of the above-mentioned implementation methods are executed. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments of the present application will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0028] Figure 1 A first schematic diagram of the architecture of the ablation situation determination device provided in an embodiment of the present application;

[0029] Figure 2 A schematic diagram of a first impedance detection circuit provided in an embodiment of the present application;

[0030] Figure 3 This is a structural example diagram of a first impedance measurement unit provided in an embodiment of the present application;

[0031] Figure 4 A first example diagram of a first impedance detection circuit of an ablation situation determination device provided in an embodiment of the present application;

[0032] Figure 5 An example diagram of a wall-attaching detection circuit is added to the first example diagram of the first impedance detection circuit provided in an embodiment of the present application;

[0033] Figure 6 A second exemplary diagram of a first impedance detection circuit of the ablation situation determination device provided in an embodiment of the present application;

[0034] Figure 7 A second schematic diagram of the architecture of the ablation situation determination device provided in an embodiment of the present application;

[0035] Figure 8 An example diagram of a first setting position of a temperature detection module provided in an embodiment of the present application;

[0036] Fig. 9 An example diagram of a second setting position of the temperature detection module provided in an embodiment of the present application;

[0037] Fig.10 A comparison diagram of an ultrasound image (a) of a target ablation tissue before ablation and an ultrasound image (b) after ablation provided in an embodiment of the present application;

[0038] Fig.11 An example diagram of the relationship between grayscale value and temperature change provided in the embodiment of the present application;

[0039] Fig.12 A flowchart of the ablation endpoint determination method provided in an embodiment of the present application;

[0040] Fig.13A schematic diagram of the structure of an electronic device provided in an embodiment of the present application.

[0041] Icons: ablation situation judgment device-1000; first impedance detection circuit-100; first impedance measurement unit-110; first impedance detection switch-120; first end switch-121; second end switch-122; first switch-123; second switch-124; ablation situation judgment module-200; ablation switch-300; wall detection circuit-400; wall detection switch-410; neutral electrode-420; second impedance measurement unit-430; temperature detection module-500; electronic device-600; processor-601; memory-602. DETAILED DESCRIPTION

[0042] The technical solutions in the embodiments of the present application will be described below in conjunction with the accompanying drawings in the embodiments of the present application. For example, the flowcharts and block diagrams in the accompanying drawings show the possible architectures, functions and operations of the systems, methods and computer program products according to multiple embodiments of the present invention. In this regard, each box in the flowchart or block diagram may represent a module, a program segment or a part of a code, and the module, a program segment or a part of a code contains one or more executable instructions for implementing the specified logical functions. It should also be noted that in some alternative implementations, the functions marked in the box may also occur in an order different from that marked in the accompanying drawings. For example, two consecutive boxes can actually be executed substantially in parallel, and they may sometimes be executed in the opposite order, depending on the functions involved. It should also be noted that each box in the block diagram and / or the flowchart, and the combination of boxes in the block diagram and / or the flowchart, can be implemented by a dedicated hardware-based system that performs a specified function or action, or can be implemented by a combination of dedicated hardware and computer instructions. In addition, the functional modules in the various embodiments of the present invention can be integrated together to form an independent part, or each module can exist separately, or two or more modules can be integrated to form an independent part.

[0043] Ablation is a medical technique that destroys or removes body tissue by physical or chemical means. Ablation can be used to treat abnormal tissue, such as tumors, conductive tissue with abnormal heart rhythm, or other lesions. Currently, there are many ablation methods, such as radiofrequency ablation, which uses high-frequency current to heat and destroy target tissue, and is often used to treat arrhythmias, renal artery ablation (to treat hypertension), etc.; laser ablation, which uses laser energy to destroy diseased tissue, is often used to treat dermatology and ophthalmology, etc.; cryoablation, which freezes and kills diseased tissue at extremely low temperatures (usually using liquid nitrogen or other coolants), is often used to treat tumors, etc.; chemical ablation, which uses injection of chemical drugs to dissolve or destroy diseased tissue, can be used for some special types of lesions (such as liver cancer).

[0044] During ablation, it is critical to accurately understand the ablation situation. It not only ensures the accuracy of the operation and enables the ablation to act precisely on the target ablation tissue, but also helps doctors dynamically adjust the operation through real-time feedback to avoid excessive or insufficient ablation. In addition, a comprehensive understanding of the ablation process can help prevent complications, such as damage to adjacent healthy tissues, improve the safety and effectiveness of treatment, and provide patients with personalized and optimal treatment plans.

[0045] At present, the understanding of ablation conditions comes from collecting the change in loop impedance between the neutral electrode attached to the body surface and the ablation electrode in the target ablation area, and the ablation conditions are understood through the impedance change. Taking intravascular radiofrequency ablation as an example, as the high-frequency radiofrequency energy is loaded, the ion mobility of human tissue increases, and the conductivity of the ionic solution increases with the increase in temperature. Therefore, as the tissue heats, the current resistance decreases, which is manifested as a decrease in impedance measurement. Therefore, in existing intravascular radiofrequency ablation technology, the ablation conditions are usually obtained by collecting the change in loop impedance between the neutral electrode attached to the skin and the radiofrequency electrode in the blood vessel.

[0046] However, there is a certain distance between the ablation electrode located in the target ablation area and the neutral electrode on the body surface, and the distance may be inconsistent; on the other hand, different target ablation objects may have tissue and anatomical differences; resulting in different electrode setting positions or different patients, there may be large differences in impedance values, making it difficult to accurately and real-time grasp the ablation situation.

[0047] In addition, there is also a method of determining whether an effective ablation effect is produced by setting a certain temperature and a certain time for ablation. The temperature is obtained through the temperature sensor on the ablation electrode, and the temperature of the contact surface between the ablation electrode and the target ablation area is not the temperature of the target ablation depth. Therefore, the ablation condition cannot be accurately determined by setting a sensor on the ablation electrode to obtain the ablation temperature.

[0048] Based on this, the present application proposes an ablation situation judgment device, method and computer-readable storage medium. The ablation situation judgment device detects the impedance information between two electrodes in the ablation area through a first impedance detection circuit, and uses an ablation situation judgment module to grasp the ablation situation in real time and accurately based on the obtained impedance information.

[0049] Please see Figure 1 , Figure 1This is a schematic diagram of the architecture of an ablation situation judgment device provided in an embodiment of the present application; the present application provides an ablation situation judgment device, the ablation situation judgment device 1000 is applied to an ablation device including multiple ablation electrodes, and the ablation situation judgment device 1000 includes a first impedance detection circuit 100 and an ablation situation judgment module 200.

[0050] During ablation, multiple ablation electrodes come into contact with the ablation tissue wall and release ablation energy. Taking intravascular radiofrequency ablation as an example, during the ablation process, the radiofrequency electrodes come into contact with the inner wall of the blood vessel and release radiofrequency energy.

[0051] The first impedance detection circuit 100 in the ablation situation determination device 1000 provided in the embodiment of the present application is connected to a plurality of ablation electrodes, and is used to detect first impedance information between ablation electrode pairs consisting of two ablation electrodes.

[0052] In the above process, the first impedance information is the volume impedance information between the two ablation electrodes in the ablation area. In intravascular radiofrequency ablation, the first impedance information is the volume impedance along the length of the blood vessel, which overcomes the problem in the prior art that the distance between the radiofrequency electrode and the neutral electrode may be inconsistent, as well as tissue and anatomical differences, resulting in large differences in impedance values ​​for different patients and different degrees of decrease. For a given target ablation object, the impedance value along the length of the blood vessel is not very different, so collecting the changes in the volume impedance value along the length of the artery can more accurately reflect the actual ablation situation of the target ablation point.

[0053] The ablation situation determination module 200 is connected to the first impedance detection circuit 100 . The ablation situation determination module 200 is configured to obtain first impedance information and determine the current ablation situation based on the first impedance information.

[0054] The impedance detection circuit can flexibly measure the first impedance information between ablation electrode pairs composed of two ablation electrodes in real time or time-sharing. For example, assume that there are 6 ablation electrodes, namely ablation electrode 1 to ablation electrode 6, and each ablation electrode corresponds to an ablation point. When you want to grasp the ablation situation of the target ablation point corresponding to ablation electrode 1, you can use the first impedance detection circuit 100 to detect a total of 5 first impedance information between ablation electrode 1 and ablation electrode 2, ablation electrode 1 and ablation electrode 3, ablation electrode 1 and ablation electrode 4, ablation electrode 1 and ablation electrode 5, and ablation electrode 1 and ablation electrode 6; after the ablation situation judgment module 200 obtains these 5 first impedance information, it judges the ablation situation of the ablation electrode 1 circumference based on these 5 first impedance information (ablation electrodes are usually arranged in a spiral circumference).

[0055] Similarly, as ablation proceeds, the temperature of the target ablation area should gradually rise, and the impedance between the electrodes should also show a downward trend; the ablation situation judgment device can derive the ablation progress based on the downward trend, or judge whether the target ablation effect has been achieved.

[0056] pass Figure 1 It can be known that the ablation situation judgment device 1000 provided in the embodiment of the present application detects the first impedance information between the target ablation electrode pair through the first impedance detection circuit 100, and analyzes the first impedance information through the ablation situation judgment module 200 to obtain the current ablation situation. Therefore, the ablation situation judgment device 1000 provided in the embodiment of the present application has high real-time and accuracy in judging the ablation situation because the first impedance detection circuit 100 detects the first impedance information between the two ablation electrodes in the ablation area. Real-time and accurate grasp of the ablation situation can not only avoid damage to non-target tissues caused by excessive ablation to a great extent, but also avoid poor ablation effects caused by insufficient ablation time.

[0057] In an optional embodiment, the first impedance detection circuit 100 provided in the embodiment of the present application can measure the first impedance information along the tissue wall of the ablation area between the ablation electrode pairs composed of two ablation electrodes. Figure 2 , Figure 2 A schematic diagram of a first impedance detection circuit provided in an embodiment of the present application; in an optional implementation of the embodiment of the present application, the first impedance detection circuit 100 includes a first impedance measurement unit 110 and a plurality of first impedance detection switches 120.

[0058] Each first impedance detection switch 120 connects the first impedance measurement unit 110 and an ablation electrode; that is, each ablation electrode is equipped with a first impedance detection switch 120 to control the connection between the ablation electrode and the first impedance measurement unit 110 .

[0059] The first impedance detection switch 120 is configured to form a first impedance detection path of the target ablation electrode pair when the corresponding first impedance detection switch 120 of the target ablation electrode pair is closed.

[0060] The first impedance measurement unit 110 is configured to measure first impedance information between the target ablation electrode pair.

[0061] The first impedance measuring unit 110 is an impedance measuring unit that can measure first impedance information between two ablation electrodes.

[0062] Please see Figure 3 , Figure 3 This is a structural example diagram of a first impedance measurement unit provided in an embodiment of the present application; Figure 3As shown, point a and point b can be regarded as an ablation electrode pair consisting of two ablation electrodes. Figure 3 Where R represents the volume impedance between point a and point b, that is, the first impedance information in the embodiment of the present application.

[0063] like Figure 3 A differential op amp is connected between point a and point b, Is is a 30k-100K current signal (a current signal can generate a voltage difference across human tissue), R1 and R2, as well as R1* and R2* are known resistance values, V REF is a known reference voltage. Vo is the output of amplifier U1, which can be actually collected.

[0064] The current signal Is flows through points a and b, forming a voltage difference between the two points. If the voltage at point a is Va, the voltage at point b is Vb, and R1=R1*, R2=R2*, then Vo=(Va-Vb)*(R2 / R1)+Vref, and the value of (Va-Vb) can be known. Because Va-Vb=Is*R, the impedance value of R can be obtained.

[0065] Exemplarily, the ablation electrode 1 is connected to the first impedance measurement unit 110 through its corresponding first impedance detection switch 120, and the ablation electrode 2 is connected to the first impedance measurement unit 110 through its corresponding first impedance detection switch 120. If the target research electrode pair is a target ablation electrode pair consisting of the ablation electrode 1 and the ablation electrode 2, when the first impedance detection switches 120 corresponding to the ablation electrode 1 and the ablation electrode 2 are closed, a loop of the ablation electrode 1, the ablation electrode 2 and the first impedance detection unit can be formed, and the first impedance detection unit can obtain the first impedance information between the ablation electrode 1 and the ablation electrode 2. If the first impedance information between the ablation electrode 1 and other ablation electrodes, or the first impedance information between other ablation electrodes, just close the corresponding first impedance detection switch 120. The principle is as above and will not be repeated.

[0066] pass Figure 2 and Figure 3 It can be seen that the first impedance detection circuit 100 in the ablation situation determination device 1000 provided in the embodiment of the present application is connected to multiple first impedance detection switches 120 to achieve impedance measurement between two ablation electrodes. In other words, the ablation situation determination device 1000 provided in the embodiment of the present application can quickly and flexibly measure the first impedance information between different electrode pairs, and can achieve real-time grasp of the ablation situation of each ablation point in the target ablation area.

[0067] Please see Figure 4 , Figure 4This is a first example diagram of the first impedance detection circuit of the ablation situation judgment device provided in an embodiment of the present application; in an optional embodiment, the first impedance detection switch 120 includes a first end switch 121 and a second end switch 122.

[0068] The first end switch 121 connects the first end of the first impedance measurement unit 110 and the target ablation electrode.

[0069] The second end switch 122 connects the second end of the first impedance measurement unit 110 and the target ablation electrode.

[0070] The first end switch 121 and the second end switch 122 are configured to form a first impedance detection path of a target ablation electrode pair including a first target ablation electrode and a second target ablation electrode when the first end switch 121 corresponding to the first target ablation electrode and the second end switch 122 corresponding to the second target electrode are closed, or when the second end switch 122 corresponding to the first target ablation electrode and the first end switch 121 corresponding to the second target electrode are closed.

[0071] It should be noted that in the above process, the first end switch 121 and the second end switch 122 can be as follows: Figure 4 The two independent switches shown can also be replaced by a single-pole double-throw switch, so that the ablation electrode can be connected to both ends of the first ablation impedance measurement unit by controlling the switch, and any other ablation electrode can be matched to form an impedance measurement loop.

[0072] For example, Figure 4 As shown, the first end switch of ablation electrode 1 is K1, and the second end switch is K2; the first end switch of ablation electrode 2 is K3, and the second end switch is K4; the first end switch of ablation electrode 3 is K5, and the second end switch is K6; the first end switch of ablation electrode 4 is K7, and the second end switch is K8; the first end switch of ablation electrode 5 is K9, and the second end switch is K10; the first end switch of ablation electrode 6 is K11, and the second end switch is K12.

[0073] Among them, K1, K3, K5, K7, K9, and K11 are connected to the first end of the first impedance measurement unit 110; K2, K4, K6, K8, K10, and K12 are connected to the first end of the first impedance measurement unit 110. When K1 and K4 are closed, the first impedance between the ablation electrode 1 and the ablation electrode 2 can be obtained.

[0074] If you want to study the ablation situation of the target ablation point corresponding to the ablation electrode 1, you can perform the following operations: close K1 and K4 to record the first impedance R12 between the ablation electrode 1 and the ablation electrode 2; close K1 and K6 to record the first impedance R13 between the ablation electrode 1 and the ablation electrode 3; close K1 and K8 to record the first impedance R14 between the ablation electrode 1 and the ablation electrode 4; close K1 and K10 to record the first impedance R15 between the ablation electrode 1 and the ablation electrode 5; close K1 and K12 to record the first impedance R16 between the ablation electrode 1 and the ablation electrode 6.

[0075] If you want to study the ablation situation of the target ablation point corresponding to the ablation electrode 1, you can also perform the following operations: close K2 and K3, record the first impedance R12 between the ablation electrode 1 and the ablation electrode 2; close K2 and K5, record the first impedance R13 between the ablation electrode 1 and the ablation electrode 3; close K2 and K7, record the first impedance R14 between the ablation electrode 1 and the ablation electrode 4; close K2 and K9, record the first impedance R15 between the ablation electrode 1 and the ablation electrode 5; close K2 and K11, record the first impedance R16 between the ablation electrode 1 and the ablation electrode 6.

[0076] The collected R12, R13, R14, R15, and R16 are acquired by the ablation situation judgment module 200, and the ablation situation judgment module 200 analyzes the ablation situation of the target ablation point corresponding to the ablation electrode 1 based on the collected 6 first impedances.

[0077] Similarly, the ablation conditions of target ablation points corresponding to other ablation electrodes are judged in accordance with the principle of the above process and will not be described in detail.

[0078] pass Figure 4 It can be seen that the embodiment of the present application provides an example of a first impedance detection circuit 100, and provides a first detection scheme for realizing the first impedance information between two ablation electrodes. Each electrode is connected to the two ends of the first impedance detection unit through a switch, and the combination of different ablation electrodes is realized by turning on and off the switch, and the first impedance between different ablation electrodes is measured. By measuring the first impedance information between the target ablation electrode and other ablation electrodes, the ablation condition of the target ablation point corresponding to the target ablation electrode can be judged; it not only overcomes the inaccuracy and individual differences of the impedance obtained from the ablation electrode to the body surface electrode by the traditional method, but also can accurately and real-time obtain the ablation condition of the target ablation area, ensuring the safety and effectiveness of the smile surgery.

[0079] In an optional embodiment, the ablation situation determination device 1000 further includes a plurality of ablation switches 300 and a wall adhesion detection circuit 400 having a plurality of wall adhesion detection switches 410 .

[0080] Each ablation switch 300 is connected to the wall adhesion detection circuit 400 and an ablation electrode. The ablation switch 300 is configured to form a wall adhesion detection loop including the ablation electrode and the wall adhesion detection circuit 400 when the ablation switch 300 and the corresponding wall adhesion detection switch 410 are closed.

[0081] Please refer to Figure 5 , Figure 5 Based on the first example diagram of the first impedance detection circuit 100 provided in the embodiment of the present application, an example diagram of the wall detection circuit 400 is added. Figure 5 As shown, the wall adhesion detection circuit 400 further includes a neutral electrode 420 and a second impedance measurement unit 430 .

[0082] The neutral electrode 420 is disposed on the surface of the target ablation object. The first end of the second impedance measurement unit 430 is respectively connected to the plurality of ablation electrodes via the plurality of wall-attachment detection switches 410. The second end of the second impedance measurement unit 430 is connected to the neutral electrode 420.

[0083] The second impedance measurement unit 430 is configured to measure second impedance information between the neutral electrode 420 and the ablation electrode corresponding to the wall detection switch 410 when the wall detection switch 410 and the corresponding ablation switch 300 are closed.

[0084] In short, in order to detect the wall adhesion performance of the ablation electrode, the implementation of the present application measures the second impedance between the ablation electrode and the surface of the target ablation object at the beginning of ablation. The main part of the embodiment of the present application to achieve impedance measurement is the second impedance measurement unit 430. A wall adhesion detection switch 410 is set between each ablation electrode and the second impedance measurement unit 430. When the ablation energy has begun to be released (that is, the ablation switch 300 has been closed), the corresponding wall adhesion detection switch 410 is closed, and then a second impedance measurement loop between the target ablation electrode and the neutral electrode 420 on the surface of the body can be formed.

[0085] For example, Figure 5 As shown, the ablation switch 300 is OUT+ and OUT-, and the wall detection switch 410 is RF; Figure 4 OUT1+ to OUT6+ are ablation switches 300 for ablation electrodes 1 to 6, Figure 4 The wall adhesion detection switches 410RF1, RF2, RF3, RF4, RF5 and RF6 are respectively the wall adhesion detection switches 410 for ablation electrode 1, ablation electrode 2, ablation electrode 3, ablation electrode 4, ablation electrode 5 and ablation electrode 6.

[0086] Usually, during ablation, the ablation switch 300 (OUT+ and OUT-) is closed to turn on the RF energy; first, it is detected whether the ablation electrode is well attached to the wall. Good attachment to the wall can be achieved by the wall detection circuit 400, that is, on this basis, the corresponding wall detection switch 410 (RF) is closed. For example, Figure 4 As shown, assuming that the second impedance between the ablation electrode 1 and the neutral electrode 420 is to be measured, OUT1+ and OUT- corresponding to the ablation electrode 1 are closed, and RF1 is closed at the same time, then the second impedance measurement unit 430 can measure the second impedance information between the ablation electrode 1 and the ablation electrode 2.

[0087] It can be understood that the second impedance information is the impedance between the ablation electrode located in the ablation area and the electrode on the body surface of the target ablation object, and the fit between the ablation electrode and the target ablation tissue wall can be judged based on empirical data through the second impedance information between the target ablation electrode and the neutral electrode 420. If the fit is good, the second impedance will be relatively stable within the preset impedance range; if the fit is poor, the second impedance may fluctuate or be out of the preset impedance range.

[0088] If there is a poor fit, the ablation effect may be poor, the target ablation point cannot be effectively ablated, and the first impedance information between the two ablation electrodes cannot be accurately detected. Corresponding intervention measures are required, such as readjusting the electrode position, etc. Therefore, judging the wall adhesion of the ablation electrode at the beginning of ablation is of great significance to the ablation effect and efficiency.

[0089] pass Figure 5 It can be seen that the ablation situation judgment device 1000 provided in the embodiment of the present application is provided with a wall adhesion detection circuit 400. The wall adhesion detection circuit 400 can measure the second impedance information between the target ablation electrode and the neutral electrode 420 arranged on the surface of the ablation object. According to the second impedance information, the wall adhesion situation of the target ablation electrode can be judged, so as to achieve effective ablation, and ensure that the first impedance information between the two ablation electrodes is available, which is conducive to accurately grasping the ablation situation of the target ablation area.

[0090] In an optional embodiment, the first impedance detection switch 120 includes a first switch 123 and a second switch 124 .

[0091] The first switch 123 connects the first end of the first impedance measurement unit 110 and the first target ablation electrode. The second switch 124 connects the second end of the first impedance measurement unit 110 and the second target ablation electrode.

[0092] The first switch 123 and the second switch 124 are configured to form a first impedance measurement path including the first target ablation electrode, the second target ablation electrode, and the first impedance measurement unit 110 when the first switch 123 and the second switch 124 are closed.

[0093] For example, see Figure 6 , Figure 6 A second exemplary diagram of a first impedance detection circuit of the ablation situation determination device provided in an embodiment of the present application; Figure 4 There are 6 ablation electrodes, namely ablation electrode 1 to ablation electrode 6, and each ablation electrode corresponds to an ablation point. Figure 6 There are 12 ablation electrodes in the apparatus, and every two ablation electrodes correspond to one ablation point.

[0094] exist Figure 6 In the embodiment, ablation electrode 11 is connected to the first switch K11, and ablation electrode 12 is connected to the second switch K12; ablation electrode 11 and ablation electrode 12 jointly realize ablation of ablation point 1. Melting electrode 21 is connected to the first switch K21, and ablation electrode 22 is connected to the second switch K22; ablation electrode 21 and ablation electrode 22 jointly realize ablation of ablation point 2. Melting electrode 31 is connected to the first switch K31, and ablation electrode 32 is connected to the second switch K32; ablation electrode 31 and ablation electrode 32 jointly realize ablation of ablation point 3. Melting electrode 41 is connected to the first switch K41, and ablation electrode 42 is connected to the second switch K42; ablation electrode 41 and ablation electrode 42 jointly realize ablation of ablation point 4. Melting electrode 51 is connected to the first switch K51, and ablation electrode 52 is connected to the second switch K52; ablation electrode 51 and ablation electrode 52 jointly realize ablation of ablation point 5. The melting electrode 61 is connected to the first switch K61 , and the ablation electrode 62 is connected to the second switch K62 ; the ablation electrode 61 and the ablation electrode 62 together realize ablation of the ablation point 6 .

[0095] Taking ablation point 1 as an example, the first switch K11 and the second switch K12 are closed to form a first impedance measurement path including ablation electrode 11, ablation electrode 12 and a first impedance measurement unit 110, so as to measure the first impedance information between ablation electrode 11 and ablation electrode 12.

[0096] It should be noted that the structure in the second example diagram of the first impedance detection circuit 100 provided in the embodiment of the present application can still be superimposed on the above-mentioned wall adhesion detection circuit 400 to realize the judgment of the wall adhesion status of the ablation electrode at the beginning of ablation. The principle will not be repeated here.

[0097] It can be seen from this that the structure of the second example diagram of the first impedance detection circuit 100 provided in the embodiment of the present application replaces the correspondence between one ablation point and one ablation electrode with one ablation point and two ablation electrodes; thereby, the implementation architecture of the impedance measurement between two points in the target ablation area to grasp the ablation situation is simpler, and the ablation situation can be grasped efficiently and accurately with a simpler structure.

[0098] Please see Figure 7 , Figure 7 This is a second schematic diagram of the architecture of the ablation situation determination device provided in an embodiment of the present application; in an optional embodiment, the ablation situation determination device 1000 further includes a temperature detection module 500 .

[0099] The temperature detection module 500 is connected to the ablation situation determination module 200 and is configured to detect temperature information of the target ablation area.

[0100] The ablation situation determination module 200 is further configured to determine the current ablation situation based on the first impedance information and the temperature information.

[0101] In addition to the above-mentioned determination of the ablation situation of the target ablation area based on the first impedance information, a temperature detection module 500 may be added to the ablation situation determination device 1000 provided in the embodiment of the present application. The temperature detection module 500 is used to detect the temperature of the target ablation area, and the measured temperature information is added to the determination of the ablation situation.

[0102] Optionally, see Figure 8 and Fig. 9 , Figure 8 An example diagram of a first setting position of a temperature detection module provided in an embodiment of the present application; Fig. 9 This is an example diagram of the second setting position of the temperature detection module provided in the embodiment of the present application. Figure 8 and Fig. 9 In the example of a mesh stent as a support, an ultrasound source is provided on the central operating wire of the mesh stent. Figure 8 and Fig. 9 There are two different ways to set up the ultrasound source.

[0103] The ultrasound source determines the temperature of the current ablation point and the tissue condition at a certain depth by emitting ultrasound and collecting ultrasonic echo signals. That is, the transmission rate of ultrasound is related to tissue density. Therefore, the ablation condition and single-point ablation condition can be determined.

[0104] There is a certain relationship between the frequency, power and depth of ultrasound acquisition; in addition, ultrasound can be set to emit ultrasound waves in all directions, so as to image the ablation location in front, behind, left and right.

[0105] Figure 8 The ultrasound source is set in the middle of the central operating wire. Fig. 9 The ultrasound sources are distributed at three different positions on the central operating wire. Figure 8 and Fig. 9 The two ultrasound source settings provided in the present invention can also be set at other locations as long as good imaging of the ablation area can be achieved. Figure 8 and Fig. 9 The electrode setting method provided in the article is to set two ablation electrodes at one ablation point. Figure 8 and Fig. 9 In some embodiments, the electrodes may be arranged in such a way that one ablation point corresponds to one ablation electrode, for a total of 6 ablation electrodes. In some embodiments, the number of ablation points or ablation electrodes may be adaptively increased or decreased according to actual conditions.

[0106] It is worth noting that since the ultrasound source provided in the embodiment of the present application is an ultrasound transducer with a polygonal cross-section, each face of the transducer can emit an ultrasonic signal; therefore, the temperature detection module 500 provided in the embodiment of the present application measures the temperature of the ablation area in real time, which is a real-time detection of the real-time ablation temperature within a certain depth.

[0107] Specifically, the temperature detection module 500 provided in the embodiment of the present application realizes the measurement of temperature in the following manner: the echo signal collected by the ultrasonic transducer is converted into an image before ablation, and the image is used as a reference image; then, during the ablation process, the image of a certain ablation depth of the ablation site is collected in real time by the ultrasonic transducer, and the temperature at a certain depth of the ablation site is determined by comparing the gray value with the reference image. Fig.10 , Fig.10 The ultrasound image (a) of the target ablation tissue before ablation and the ultrasound image (b) after ablation provided in the embodiment of the present application are compared; the white dots in the white framed area in (a) are the positions of the ablation electrodes before ablation, and the range of the white dots in the white framed area in (a) gradually expands as the radio frequency progresses. After performing difference processing and wavelet transform analysis on the ultrasound images before and after ablation, the grayscale texture feature parameters are extracted, and a linear correlation fitting analysis is performed with the temperature to obtain the relationship between the grayscale value and the temperature. Please refer to Fig.11 , Fig.11 The gray value and temperature variation relationship diagram provided in the embodiment of the present application; Fig.11 It can be seen that as the ablation temperature increases, the gray value gradually increases, and the current ablation temperature can be determined through the relationship between the gray value and the temperature change.

[0108] pass Figures 7 to 11It can be seen that the ablation situation judgment device 1000 provided in the embodiment of the present application can provide a more comprehensive ablation situation judgment by adding a temperature detection module 500 to monitor the real-time ablation temperature at a certain depth of the target ablation area in real time, which can be used in combination with the first impedance information. It helps to more accurately monitor and control the ablation process, avoid tissue damage caused by overheating or insufficient ablation caused by too low a temperature, and further improve the safety and efficacy of the operation.

[0109] In an optional implementation manner of the embodiment of the present application, the ablation situation determination module 200 is specifically used to:

[0110] Determine whether the decrease amplitude of the first impedance information reaches an impedance decrease threshold, and / or determine whether the temperature information reaches a temperature threshold and maintains a preset time length.

[0111] If the decrease amplitude of the first impedance information reaches the impedance decrease threshold, and / or the temperature information reaches the temperature threshold and is maintained for a preset time period, it is determined that the ablation endpoint is reached.

[0112] Exemplarily, taking an ablation point corresponding to an ablation electrode as an example, suppose that the ablation situation of ablation electrode 4 is to be understood at present. Then, at the beginning of ablation, the impedance product between each electrode is measured first and saved as basic impedance data. After ablation has been carried out for a period of time, the ablation situation of ablation electrode 4 is studied, then K8 and K9 are controlled to be closed, K8 and K11 are closed, K8 and K5 are controlled to be closed, K8 and K3 are closed, and K8 and K1 are closed. The first impedance value between ablation electrode 4 and the other five ablation electrodes is obtained. These six impedance information and the basic impedance data measured at the beginning of ablation are analyzed to see whether they have reached the preset drop preset value, for example, they have all dropped to more than 10%. Or five of the first impedance values ​​have dropped by more than 10%. At the same time, the temperature detection module 500 detects that the temperature rise of ablation point 4 at a certain ablation depth maintains a stable preset period, for example, it maintains stability for 10s, then it can be judged that the current ablation situation has reached the ablation end point, then the ablation switch 300 corresponding to the ablation electrode 4 can be turned off. Of course, in some embodiments, the ablation situation can be understood based solely on the first impedance value between electrodes, or based solely on the ablation temperature at a certain ablation depth.

[0113] In the embodiment of the present application, when the ablation situation judgment module 200 determines that the target ablation point has reached the ablation endpoint, the relevant ablation switch 300 will be turned off to stop outputting ablation energy to the outside, thereby avoiding excessive ablation of the blood vessel wall and causing damage.

[0114] It can be seen from this that the ablation situation judgment module 200 of the ablation situation judgment device 1000 provided in the embodiment of the present application can directly judge that the ablation end point has been reached by obtaining the decrease amplitude of the first impedance information, and / or whether the temperature information of a certain ablation depth reaches the temperature threshold and maintains for a certain period of time. Otherwise, ablation continues. Therefore, the ablation situation judgment device 1000 provided in the embodiment of the present application can analyze the collected data through the ablation situation judgment module 200 to achieve efficient and accurate grasp of the ablation situation.

[0115] In an optional embodiment, the ablation condition judgment device 1000 provided in the embodiment of the present application is also provided with a display module, and the display module can display the measured first impedance information, second impedance information, temperature information, and ablation condition of the ablation channel.

[0116] Please see Fig.12 , Fig.12 Flow chart of the ablation endpoint determination method provided in the embodiment of the present application; the present application provides an ablation endpoint determination method, which is applied to an ablation situation determination device, and the ablation situation determination device includes a first impedance detection circuit and an ablation situation determination module. The ablation endpoint determination method can be Fig.12 The electronic device provided is implemented, and the ablation endpoint determination method comprises the following steps:

[0117] Step S100: obtaining first impedance information between the target ablation electrode and other ablation electrodes by a first impedance detection circuit.

[0118] In step S100, the first impedance detection circuit detects the first impedance information between the target electrode and other ablation electrodes. The ablation electrodes in the embodiment of the present application include the target ablation electrode and other ablation electrodes, which are attached to the target ablation tissue wall and used to release ablation energy.

[0119] Optionally, the impedance information between the target ablation electrode and one other ablation electrode is measured in time-sharing manner until the impedance information between the target ablation electrode and all other ablation electrodes is measured; and the ablation electrode for which the impedance information measurement is not performed is controlled to output ablation energy.

[0120] for Figure 4 The structure in:

[0121] When K1 and K4 (or K2 and K3) are connected, the first impedance between ablation electrode 1 and ablation electrode 2 can be measured. When K1 and K6 (or K2 and K5) are connected, the first impedance between ablation electrode 1 and ablation electrode 3 can be measured. When K1 and K8 (or K2 and K7) are connected, the first impedance between ablation electrode 1 and ablation electrode 4 can be measured. When K1 and K10 (or K2 and K9) are connected, the first impedance between ablation electrode 1 and ablation electrode 5 can be measured. When K1 and K12 (or K2 and K11) are connected, the first impedance between ablation electrode 1 and ablation electrode 6 can be measured.

[0122] When K3 and K6 (or K4 and K5) are connected, the first impedance between ablation electrode 2 and ablation electrode 3 can be measured. When K3 and K8 (or K4 and K7) are connected, the first impedance between ablation electrode 2 and ablation electrode 4 can be measured. When K3 and K10 (or K4 and K9) are connected, the first impedance between ablation electrode 2 and ablation electrode 5 can be measured. When K3 and K12 (or K4 and K11) are connected, the first impedance between ablation electrode 2 and ablation electrode 6 can be measured.

[0123] When K5 and K8 (or K6 and K7) are connected, the first impedance between the ablation electrode 3 and the ablation electrode 4 can be measured; when K5 and K10 (or K6 and K9) are connected, the first impedance between the ablation electrode 3 and the ablation electrode 5 can be measured; when K5 and K12 (or K6 and K11) are connected, the first impedance between the ablation electrode 3 and the ablation electrode 6 can be measured.

[0124] When K7 and K10 (or K8 and K9) are connected, the first impedance between the ablation electrode 4 and the ablation electrode 5 can be measured; when K7 and K12 (or K8 and K11) are connected, the first impedance between the ablation electrode 4 and the ablation electrode 6 can be measured.

[0125] When K9 and K12 (or K10 and K11) are turned on, the first impedance between the ablation electrode 5 and the ablation electrode 6 can be measured.

[0126] When the corresponding first impedance needs to be measured, the corresponding switch is controlled to be on or off.

[0127] Step S200: The ablation situation determination circuit determines whether the target ablation point corresponding to the target electrode has reached the ablation endpoint according to the impedance information.

[0128] In the above step S200, taking an example that one ablation point corresponds to one ablation electrode, it is assumed that the ablation status of ablation electrode 4 is to be understood at present. Then, at the beginning of ablation, the impedance product between each electrode is first measured and saved as basic impedance data. After ablation has been carried out for a period of time, the ablation status of ablation electrode 4 is studied, then K8 and K9 are controlled to be closed, K8 and K11 are closed, K8 and K5 are controlled to be closed, K8 and K3 are closed, and K8 and K1 are closed. The first impedance value between ablation electrode 4 and the other five ablation electrodes is obtained. These six impedance information are analyzed with the basic impedance data measured at the beginning of ablation to see whether they have reached the preset drop preset value, for example, all dropped to more than 10%. Or the five first impedance values ​​all drop by more than 10%, so as to determine whether the ablation point corresponding to ablation electrode 4 has reached the ablation end point.

[0129] When the decrease in the first impedance value between the ablation electrodes corresponding to all ablation points reaches a preset decrease value, the entire ablation operation can be stopped.

[0130] In an optional embodiment, the ablation situation judgment module also includes a wall adhesion detection circuit; before obtaining the impedance information between the target ablation electrode and other ablation electrodes, the ablation endpoint judgment method also includes: using the wall adhesion detection circuit to detect the adhesion of the ablation electrodes including the target ablation electrode and other ablation electrodes to the ablation tissue wall.

[0131] In an optional embodiment, the ablation temperature at a certain ablation depth can be obtained by a temperature detection module, such as an ultrasonic transducer, provided in the ablation condition judgment device, and whether the ablation endpoint is reached can be judged by the temperature and the temperature stabilization time.

[0132] pass Fig.12It can be seen that the existing technology judges the ablation endpoint through fixed time, fixed output energy, impedance change and other methods, which are indirect judgment methods. Since nerves are usually distributed around the blood vessel wall, and this traditional ablation endpoint judgment method is closely related to the reliability of the radio frequency electrode's adhesion to the blood vessel wall, the temperature sensor on the radio frequency electrode collects the temperature of the electrode and tissue contact surface, rather than the temperature of a certain ablation depth. Relying solely on the completion of ablation timing or the number of ablation points, there is a subjective judgment that the nerve has been damaged based on historical exploration data, and it cannot accurately and reliably judge whether the nerve has been ablated. There is also a method that uses electrical stimulation of the renal artery sympathetic nerves or ganglia to judge the ablation endpoint by evaluating blood pressure changes and other physiological indicators, but the time of sympathetic nerve regulation in different patients is not consistent, and a unified indicator cannot be formed. The ablation endpoint judgment method provided in the embodiment of the present application is based on the change of volume impedance value collected along the length of the artery by the ablation endpoint judgment device, which can better reflect the actual ablation effect of the ablation point. At the same time, an omnidirectional ultrasonic transducer can be set on the central wire drawing of the catheter to detect the actual ablation temperature within a certain depth in real time, which can intuitively and directly evaluate the degree of nerve damage achieved by ablation and accurately and timely determine the ablation endpoint.

[0133] See also Fig.13 , Fig.13 A schematic diagram of the structure of an electronic device provided in an embodiment of the present application. An electronic device 600 provided in an embodiment of the present application comprises: a processor 601 and a memory 602, wherein the memory 602 stores machine-readable instructions executable by the processor 601, and when the machine-readable instructions are executed by the processor 601, the steps in any implementation of the above-mentioned ablation situation determination method are executed.

[0134] Based on the same inventive concept, an embodiment of the present application also provides a computer-readable storage medium, in which computer program instructions are stored. When the computer program instructions are read and executed by a processor, the steps in any implementation method of the above-mentioned ablation situation judgment method are executed.

[0135] The computer-readable storage medium may be a random access memory (RAM), a read-only memory (ROM), a programmable read-only memory (PROM), an erasable programmable read-only memory (EPROM), an electrically erasable programmable read-only memory (EEPROM), or any other medium that can store program code.

[0136] In this article, relational terms such as first and second, etc. are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the statement "include..." do not exclude the presence of other identical elements in the process, method, article or device including the elements.

[0137] The above description is only an embodiment of the present application and is not intended to limit the protection scope of the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. An ablation condition judgment device, characterized in that: The ablation situation judgment device is applied to an ablation device including a plurality of ablation electrodes, and the ablation situation judgment device includes: a first impedance detection circuit and an ablation situation judgment module; The first impedance detection circuit is connected to the plurality of ablation electrodes and is configured to detect first impedance information between the target ablation electrode pair; The ablation situation judgment module is connected to the first impedance detection circuit, and the ablation situation judgment module is configured to obtain the first impedance information and judge the current ablation situation based on the first impedance information.

2. The ablation condition determination device according to claim 1, characterized in that: The first impedance detection circuit includes a first impedance measurement unit and a plurality of first impedance detection switches; Each of the first impedance detection switches is connected to the first impedance measurement unit and one of the ablation electrodes; The first impedance detection switch is configured to form a first impedance detection path of the target ablation electrode pair when the corresponding first impedance detection switch of the target ablation electrode pair is closed; The first impedance measurement unit is configured to measure first impedance information between the target ablation electrode pair.

3. The ablation condition determination device according to claim 2, characterized in that: The first impedance detection switch includes a first end switch and a second end switch; The first-end switch connects the first end of the first impedance measurement unit and the target ablation electrode; The second end switch connects the second end of the first impedance measurement unit and the target ablation electrode; The first end switch and the second end switch are configured to form a first impedance detection path of a target ablation electrode pair including the first target ablation electrode and the second target ablation electrode when the first end switch corresponding to the first target ablation electrode and the second end switch corresponding to the second target electrode are closed, or when the second end switch corresponding to the first target ablation electrode and the first end switch corresponding to the second target electrode are closed.

4. The ablation condition determination device according to claim 3, characterized in that: The ablation situation determination device further includes a plurality of ablation switches and a wall adhesion detection circuit having a plurality of wall adhesion detection switches; Each of the ablation switches is connected to the wall adhesion detection circuit and an ablation electrode, and the ablation switch is configured to form a wall adhesion detection loop including the ablation electrode and the wall adhesion detection circuit when the ablation switch and the corresponding wall adhesion detection switch are closed.

5. The ablation condition determination device according to claim 4, characterized in that: The wall adhesion detection circuit also includes a neutral electrode and a second impedance measurement unit; The neutral electrode is arranged on the surface of the target ablation object; The first end of the second impedance measurement unit is respectively connected to the plurality of ablation electrodes through the plurality of wall adhesion detection switches; The second end of the second impedance measurement unit is connected to the neutral electrode; The second impedance measurement unit is configured to measure second impedance information between the neutral electrode and the ablation electrode corresponding to the wall detection switch when the wall detection switch is closed and the corresponding ablation switch is closed.

6. The ablation condition determination device according to claim 2, characterized in that: The first impedance detection switch includes a first switch and a second switch; The first switch connects the first end of the first impedance measurement unit and the first target ablation electrode; The second switch connects the second end of the first impedance measurement unit and the second target ablation electrode; The first switch and the second switch are configured to form a first impedance measurement path including the first target ablation electrode, the second target ablation electrode, and the first impedance measurement unit when the first switch and the second switch are closed.

7. The ablation condition determination device according to claim 1, characterized in that: The ablation condition determination device further includes a temperature detection module; The temperature detection module is connected to the ablation situation judgment module and is configured to detect temperature information of the target ablation area; The ablation situation determination module is further configured to determine the current ablation situation based on the first impedance information and temperature information.

8. The ablation condition determination device according to claim 7, characterized in that: The ablation situation determination module is specifically used for: Determine whether the decrease amplitude of the first impedance information reaches an impedance decrease threshold, and / or determine whether the temperature information reaches a temperature threshold and maintains a preset time length; If the decrease amplitude of the first impedance information reaches the impedance decrease threshold, and / or the temperature information reaches the temperature threshold and is maintained for a preset time period, it is determined that the ablation endpoint is reached.

9. A method for determining an ablation endpoint, characterized in that: The ablation endpoint judgment method is applied to an ablation situation judgment device, wherein the ablation situation judgment device comprises a first impedance detection circuit and an ablation situation judgment module; the ablation endpoint judgment method comprises: The first impedance detection circuit obtains first impedance information between the target ablation electrode and other ablation electrodes; The ablation situation judgment circuit judges whether the target ablation point corresponding to the target electrode reaches the ablation endpoint according to the impedance information; The target ablation electrode and other ablation electrodes are attached to the target ablation tissue wall and are used to release ablation energy.

10. The ablation endpoint determination method according to claim 9, characterized in that: The ablation situation judgment module further includes a wall adhesion detection circuit; before acquiring the impedance information between the target ablation electrode and other ablation electrodes, the ablation endpoint judgment method further includes: The wall adhesion detection circuit detects the adhesion of the ablation electrodes including the target ablation electrode and other ablation electrodes to the ablation tissue wall.

11. The ablation endpoint determination method according to claim 9, characterized in that: The obtaining of first impedance information between the target ablation electrode and other ablation electrodes includes: measuring the impedance information between the target ablation electrode and one other ablation electrode in a time-sharing manner until the measurement of the impedance information between the target ablation electrode and all other ablation electrodes is completed; And, controlling the ablation electrode that is not performing impedance information measurement to output ablation energy.

12. A computer-readable storage medium, characterized in that: The computer-readable storage medium stores computer program instructions, and when the computer program instructions are executed by a processor, the steps in the method according to any one of claims 9 to 11 are executed.

Images