Liquid composition containing EGCG monopalmitate for disinfection

Abstract

The invention relates to a liquid composition containing EGCG monopalmitate and ethanol for disinfection, a wet tissue containing the liquid composition, and application of the liquid composition and / or the wet tissue.

Description

Technical Field

[0001] The invention relates to a liquid composition containing EGCG monopalmitate and ethanol, a wet wipe containing the liquid composition, and applications of the liquid composition and / or the wet wipe. Background Art

[0002] EGCG (Epigallocatechin gallate) is one of the components of green tea polyphenols. It is a catechin monomer isolated from tea leaves. It has antibacterial, antiviral, antioxidant, anti-atherosclerotic, anti-thrombotic, anti-angiogenic, anti-inflammatory and anti-tumor effects. Antiviral studies on EGCG have found that (Int. J. Mol. Sci. 2022, 23, 9842; Journal of Virology, 2014, 88(14): 7806-7817; Phytomedicine, 2021(85): 153286; CN 105535012 B) it has been shown to exhibit antiviral activity against SARS-Cov-2, vesicular stomatitis virus (VSV), human immunodeficiency virus (HIV), influenza A virus (IAV), enterovirus 71, adenovirus (AdV), hepatitis B virus (HBV), herpes simplex virus type 1 and 2 (HSV-1 and -2), and hepatitis C virus (HCV).

[0003] CN112912074A discloses that a composition of EGCG-palmitate and glycerol is used to inhibit or reduce respiratory viral infections in subjects. WO2021 / 183162 and WO2021 / 183878 disclose that a composition of EGCG-palmitate, ethanol, citric acid and / or glycerol in a specific ratio range is used to kill non-enveloped viruses and spores. Summary of the invention

[0004] In a first aspect of the present invention, there is provided a liquid composition for disinfection, comprising EGCG monopalmitate, ethanol, and water;

[0005] The mass percentage of the EGCG monopalmitate is 0.05-0.5%;

[0006] The mass percentage of the ethanol is 57% to 74%;

[0007] The EGCG monopalmitate is selected from one, two, three or four of the compounds of formula Ia, Ib, Ic and Id;

[0008]

[0009]

[0010] In one embodiment of the present invention, the liquid disinfectant composition further comprises a quaternary ammonium salt. In one embodiment of the present invention, the quaternary ammonium salt is a chloride-type quaternary ammonium salt and / or a bromide-type quaternary ammonium salt. In one embodiment of the present invention, the mass percentage of the quaternary ammonium salt is 0.05% to 0.3%. In one embodiment of the present invention, the mass percentage of the quaternary ammonium salt is 0.05% to 0.2%.

[0011] In one embodiment of the present invention, the liquid composition for disinfection also includes a moisturizer. A moisturizer is a type of (cosmetic) raw material that can increase or maintain moisture in the upper layer of the skin over a wide relative humidity range and for a long time in the product. This type of raw material has low volatility and can retain moisture and be absorbed on the skin surface. In one embodiment of the present invention, the moisturizer is selected from one or more of glycerol, propylene glycol, sorbitol, butylene glycol, polyethylene glycol, sodium hyaluronate, and panthenol (provitamin B5). In one embodiment of the present invention, the mass percentage of the moisturizer is 4% to 16% or 5% to 10% or 10% to 15%.

[0012] In one embodiment of the present invention, the liquid disinfection composition also includes a preservative. Preservatives are a class of substances that prevent products from spoiling and extend the shelf life of products. In one embodiment of the present invention, the preservative is selected from one or more of methyl parahydroxybenzoate, sodium methyl parahydroxybenzoate, ethyl parahydroxybenzoate, sodium ethyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium propyl parahydroxybenzoate, benzoic acid, sodium benzoate, potassium metabisulfite, sodium metabisulfite, sodium sulfite, sodium bisulfite, sodium hyposulfite, ε-polylysine, ε-polylysine hydrochloride, sorbic acid, and potassium sorbate. In one embodiment of the present invention, the mass of the preservative is 0.25 to 2 times or 0.5 to 1 times that of EGCG monopalmitate. Parabens, commonly known as parabens, are a safe, efficient, and broad-spectrum food preservative; including their methyl, ethyl, propyl, isopropyl, butyl, isobutyl, amyl, heptyl, and octyl esters. The paraben preservatives listed in the "Food Additives Usage Standards" (GB2760-2014) include: sodium methyl parahydroxybenzoate, ethyl parahydroxybenzoate, and sodium ethyl parahydroxybenzoate.

[0013] In one embodiment of the present invention, the liquid composition for disinfection also includes a skin care agent. In one embodiment of the present invention, the skin care agent is selected from aloe extract, chamomile extract, centella asiatica extract, and honeysuckle extract. In one embodiment of the present invention, the skin care agent is preferably aloe extract. In one embodiment of the present invention, the mass percentage of the skin care agent is 1% to 10% or 5% to 15%. Aloe is a perennial succulent herb, and its extract is widely used in the cosmetics industry, with multiple functions such as moisturizing, sun protection, soothing and antipruritic, and after-sun repair. Exemplarily, the aloe extract is a clear liquid extracted by low-temperature precipitation after the aloe raw material is screened, crushed, separated, filtered and impurities removed. Chamomile extract is a dried whole herb extract of Chamomile, a plant of the Asteraceae family, and has been used as a cosmeceutical ingredient. Centella asiatica is the dried whole herb of Centella asiatica (L.) Urb., a plant of the Umbelliferae family. Honeysuckle is the dried buds or initially opened flowers of Lonicera japonica Thunb. of the Caprifoliaceae family.

[0014] In one embodiment of the present invention, the liquid disinfectant composition further comprises a flavoring agent. In one embodiment of the present invention, the flavoring agent is a water-soluble flavor. In one embodiment of the present invention, the mass of the flavoring agent is 1 to 8 times or 2 to 10 times that of EGCG monopalmitate. Water-soluble flavors, also called water-based flavors, are flavors blended from various natural or synthetic flavors; they are usually dissolved in 40% to 60% ethanol (or other water-soluble solvents such as propanol, propylene glycol, and glycerin). They are widely used in the fields of food, cosmetics, and daily chemical products. In the present invention, exemplary water-soluble flavors include, but are not limited to, water-based green tea flavors, water-based marine flavors, water-based spring flavors, osmanthus daily flavors, fragrant jasmine daily flavors, or French rose daily flavors.

[0015] In one embodiment of the present invention, the mass percentage of the EGCG monopalmitate is 0.1% to 0.3% or 0.1% to 0.25% or 0.15% to 0.3% or 0.1% to 0.2% or 0.2% to 0.3%; preferably 0.1%, 0.12%, 0.15%, 0.2%, or 0.25%. In one embodiment of the present invention, the EGCG monopalmitate is a compound of formula Ia.

[0016] In one embodiment of the present invention, the mass percentage of ethanol is 57% to 69% or 62% to 74% or 67% to 71%.

[0017] The second aspect of the present invention provides a wet wipe comprising the liquid disinfectant composition according to the first aspect of the present invention, and a carrier; the carrier is selected from non-woven fabrics, fabrics, wood pulp composite fabrics, or wood pulp paper.

[0018] In one embodiment of the present invention, nonwoven fabric, fabric, wood pulp composite fabric, or wood pulp paper is used as a carrier, and the liquid disinfectant composition of the present invention is added to make wet wipes.

[0019] Non-woven fabrics are also called non-woven fabrics. The specifications of non-woven fabrics are usually expressed by the gram weight of the non-woven fabrics. The gram weight of non-woven fabrics refers to the weight per square meter. For example, a 60g non-woven fabric means that the weight per square meter of the non-woven fabric is about 60 grams.

[0020] The third aspect of the present invention provides the use of the liquid disinfectant composition of the first aspect and the wet wipes of the second aspect for inactivating microorganisms.

[0021] In one embodiment of the present invention, the microorganism is selected from enveloped viruses and / or non-enveloped viruses. In one embodiment of the present invention, the microorganism is selected from vesicular stomatitis virus (VSV), human immunodeficiency virus (HIV), influenza A virus (IAV), enterovirus 71, adenovirus (AdV), hepatitis B virus (HBV), herpes simplex virus 1 and 2 (HSV-1 and -2), hepatitis C virus (HCV), SARS-Cov-2, norovirus.

[0022] In the present invention, the term "disinfectant" refers to a preparation used to kill microorganisms on the transmission medium to achieve disinfection or sterilization requirements. According to the classification of active ingredients, it includes but is not limited to alcohol disinfectants, chlorine-containing disinfectants, iodine-containing disinfectants, peroxide disinfectants, guanidine disinfectants, phenol disinfectants, quaternary ammonium disinfectants, etc.; according to the classification of use, it includes but is not limited to surface disinfectants, medical device disinfectants, air disinfectants, hand disinfectants, skin disinfectants, mucous membrane disinfectants, and disinfectants for epidemic sources.

[0023] The Hygienic Requirements for Quaternary Ammonium Disinfectants (GB / T 26369-2020) explains the terms "quaternary ammonium chloride" and "quaternary ammonium bromide". 18 Quaternary ammonium chloride composed of aliphatic chains (single or double chains), methyl (or benzyl, ethylbenzyl) and benzyl ammonium chloride (also known as benzethonium chloride or benzylethoxyammonium chloride) composed of pinenyl, dimethyl and benzyl. 18 The quaternary ammonium bromide salt is composed of a fatty chain (single or double chain), a methyl group (or a benzyl group, an ethyl benzyl group). Exemplary chloride-type quaternary ammonium salts include, but are not limited to, benzalkonium chloride and benzethonium chloride. Exemplary bromide-type quaternary ammonium salts include, but are not limited to, benzalkonium bromide.

[0024] In the present invention, the term "disinfectant wipes" refers to wet wipes that use non-woven fabrics, fabrics, wood pulp composites, wood pulp paper, etc. as carriers, and add appropriate amounts of disinfectants and other raw materials, which have a disinfecting effect on the treated objects (such as hands, skin, mucous membranes and the surface of ordinary objects).

[0025] In the present invention, the term "ordinary object surface" refers to the surfaces of articles, utensils, appliances and equipment in various places such as schools, childcare institutions, public places, homes, etc., as well as walls and floors.

[0026] The term "pharmaceutically acceptable" refers to those compounds, materials, compositions and / or dosage forms which, within the scope of sound medical judgment, are suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response or other problems or complications, commensurate with a reasonable benefit / risk ratio.

[0027] In the present invention, the term "comprising" or "including (comprising)" may be open, semi-closed or closed. In other words, the term also includes "consisting essentially of" or "consisting of".

[0028] In the present invention, "mass volume percentage" or "% (w / v)" or ""% w / v"" is a way of expressing mass volume concentration, which means the number of grams of solute contained in every 100 ml of solution. For example, 20% (w / v) means that 20 g of solute is contained in every 100 ml of solution.

[0029] The liquid composition containing EGCG monopalmitate and ethanol disclosed in the present invention can not only kill microorganisms that are sensitive to alcohol (e.g., about 75% v / v); it can also kill microorganisms that are insensitive to alcohol (e.g., about 75% v / v), such as non-enveloped viruses. The wet wipes made from the liquid composition of the present invention are easy to carry and use, and help to establish a clean and hygienic environment when needed. DETAILED DESCRIPTION

[0030] The present invention will be further described below in conjunction with specific examples. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. The experimental methods in the following examples without specifying specific conditions are usually carried out under conventional conditions or under conditions recommended by the manufacturer.

[0031] Unless otherwise specified, the EGCG palmitate in the specific embodiment of the present invention is a compound of formula Ia.

[0032] In the following specific embodiments, when the content or proportion of the components / materials in the formula table is expressed in mass percentage (%w / w), the sum of the mass percentages in some embodiments is not 100.00% (for example, 99.99%, 100.01%, 100.02%, etc.). This is because the values ​​of the content or proportion of each component / material are rounded off; for the purpose of intuitive expression, it is still expressed as 100.00% in the relevant embodiments.

[0033] Example 1

[0034] A 75% (v / v) ethanol solution was prepared and divided into 5 portions; EGCG palmitate was added respectively, and the amount of EGCG palmitate added was 0.1% (w / v), 0.2% (w / v), 0.3% (w / v), 0.4% (w / v), or 0.5% (w / v); EGCG palmitate was completely dissolved to obtain the corresponding solution.

[0035] A 70% (v / v) ethanol solution was prepared and divided into 5 portions; EGCG palmitate was added respectively, and the amount of EGCG palmitate added was 0.1% (w / v), 0.2% (w / v), 0.3% (w / v), 0.4% (w / v), or 0.5% (w / v); EGCG palmitate was completely dissolved to obtain the corresponding solution.

[0036] A 65% (v / v) ethanol solution was prepared and divided into two parts; EGCG palmitate was added respectively, and the amount of EGCG palmitate added was 0.1% (w / v) and 0.2% (w / v), respectively; EGCG palmitate was completely dissolved to obtain the corresponding solution.

[0037] Example 2

[0038]

[0039] Prepare a liquid composition for disinfection: take anhydrous ethanol into a liquid preparation container, add EGCG palmitate and stir to dissolve, then add methyl parahydroxybenzoate and stir to dissolve, continue to add glycerin, propylene glycol, aloe extract, and essence and stir evenly, finally add purified water and stir evenly until a clear and transparent solution is obtained.

[0040] Preparation of wet wipes: Take non-woven fabric and cut it into a suitable size; soak the non-woven fabric in the liquid composition for disinfection to prepare wet wipes. Fold the wet wipes appropriately, put them into an aluminum foil bag, and seal it.

[0041] Example 3

[0042]

[0043] Prepare a liquid composition for disinfection: take anhydrous ethanol into a liquid preparation container, add EGCG palmitate and stir to dissolve, then add methyl parahydroxybenzoate and stir to dissolve, continue to add glycerin, propylene glycol, aloe extract, and essence and stir evenly, finally add purified water and stir evenly until a clear and transparent solution is obtained.

[0044] Preparation of wet wipes: Take non-woven fabric and cut each piece into a size of about 17.5cm*15.0cm; soak the non-woven fabric in the liquid composition for disinfection to prepare wet wipes. Fold the wet wipes appropriately, put them into an aluminum foil bag (14.9cm*7.5cm), and seal it.

[0045] Example 4

[0046]

[0047] Prepare a liquid composition for disinfection: take anhydrous ethanol into a liquid preparation container, add EGCG palmitate and stir to dissolve, then add methyl parahydroxybenzoate and stir to dissolve, continue to add propylene glycol, aloe extract, and essence and stir evenly, finally add purified water and stir evenly until a clear and transparent solution is obtained.

[0048] Preparation of wet wipes: Take non-woven fabric and cut each piece into a size of about 17.5cm*15.0cm (about 1.5g / piece); use a syringe to evenly add the disinfectant liquid composition to the non-woven fabric, the amount of which is about 3.75g / piece (i.e., the amount of liquid added is about 2.5 times the weight of the fabric); prepare wet wipes. Fold the wet wipes appropriately, put them into an aluminum foil bag (14.9cm*7.5cm), and seal it.

[0049] Example 5

[0050]

[0051] Prepare liquid composition for disinfection: take anhydrous ethanol to the liquid preparation container, add EGCG palmitate and stir to dissolve, then add methyl paraben and stir to dissolve, continue to add propylene glycol, aloe extract and essence and stir evenly, finally add purified water and stir evenly until a clear and transparent solution is obtained. Take a small amount of (39-5#) liquid, place it in a vial, store it at room temperature for 7 days, no solid precipitation is observed; take a small amount of (39-6#) liquid, place it in a vial, store it at room temperature for 3.5 days, no solid precipitation is observed.

[0052] Preparation of wet wipes: Take non-woven fabric and cut each piece into a size of about 17.5cm*15.0cm (about 1.5g / piece); use a syringe to evenly add the disinfectant liquid composition to the non-woven fabric, the amount of which is about 3.75g / piece (i.e., the amount of liquid added is about 2.5 times the weight of the fabric); prepare wet wipes. Fold the wet wipes appropriately, put them into an aluminum foil bag (14.9cm*7.5cm), and seal it.

[0053] Example 6

[0054] materials Ratio / %(w / w) effect EGCG Palmitate 0.12 Propylene glycol 5.99 Moisturizer Methylparaben 0.12 preservative Aloe Vera Extract 7.64 Skin care products Water-based green tea flavor 0.52 Fragrance enhancer Ethanol 68.97 Purified water 16.64 Total 100.00

[0055] Prepare a liquid composition for disinfection: take anhydrous ethanol into a liquid preparation container, add EGCG palmitate and stir to dissolve, then add methyl parahydroxybenzoate and stir to dissolve, continue to add propylene glycol, aloe extract, and aqueous green tea essence and stir evenly, finally add purified water and stir evenly until a clear and transparent solution is obtained.

[0056] Preparation of wet wipes: Take non-woven fabric (60g specification), spray the liquid composition for disinfection evenly on the non-woven fabric (the amount of liquid sprayed is 2.5 to 3 times the weight of the fabric), and then cut the wet wipes on the production line to a size of 17.5cm*15.0cm and package and seal.

[0057] Example 7

[0058] Material Name Ratio / %(w / w) 250 tablets / g EGCG Palmitate 0.12 1.08 Propylene glycol 5.94 55.65 Methylparaben 0.12 1.08 Aloe Vera Extract 7.55 70.77 Water-based green tea flavor 0.58 5.42 Ethanol 67.84 635.98 Purified water 17.87 167.50 Total 100.00 937.48

[0059] Prepare a liquid composition for disinfection: take anhydrous ethanol into a liquid preparation container, add EGCG palmitate and stir to dissolve, then add methyl parahydroxybenzoate and stir to dissolve, continue to add propylene glycol, aloe extract, and aqueous green tea essence and stir evenly, finally add purified water and stir evenly until a clear and transparent solution is obtained.

[0060] Preparation of wet wipes: Take 60g of non-woven fabric and cut each piece into a size of about 17.5cm*15.0cm (about 1.5g / piece); add the disinfectant liquid composition evenly to the non-woven fabric with a syringe, the amount of which is about 3.75g / piece (i.e., the amount of liquid added is about 2.5 times the weight of the fabric); prepare wet wipes. Fold the wet wipes appropriately, put them into an aluminum foil bag (13.0cm*9.0cm), and seal it.

[0061] According to GB15979-2002 "Hygiene Standards for Disposable Hygiene Products", the wet wipes were tested for skin irritation, microbial limits, and bactericidal rates; the testing unit was Suzhou Customs Comprehensive Technology Center. The skin irritation test result was: non-irritating. The microbial test result was in compliance with the requirements; coliform bacteria, Pseudomonas aeruginosa, hemolytic streptococci, Staphylococcus aureus, and fungal colonies were not detected. When the test temperature was 25℃±1℃, the sample had a bactericidal effect on the experimental bacteria (Escherichia coli, Staphylococcus aureus) for 2 minutes or more.

[0062] Example 8

[0063] Material Name Ratio / %(w / w) 250 tablets / g EGCG Palmitate 0.12 1.08 Propylene glycol 5.78 54.19 Benzalkonium chloride 0.12 1.08 Aloe Vera Extract 7.51 70.45 Water-based green tea flavor 0.58 5.42 Ethanol 67.98 637.28 Purified water 17.92 167.99 Total 100.00 937.5

[0064] Prepare a liquid composition for disinfection: take anhydrous ethanol into a liquid preparation container, add EGCG palmitate and stir to dissolve, then add benzalkonium chloride and stir to dissolve, continue to add propylene glycol, aloe extract, and aqueous green tea essence and stir evenly, finally add purified water and stir evenly until a clear and transparent solution is obtained.

[0065] Preparation of wet wipes: Take 60g of non-woven fabric and cut each piece into a size of about 17.5cm*15.0cm (about 1.5g / piece); add the disinfectant liquid composition evenly to the non-woven fabric with a syringe, the amount of which is about 3.75g / piece (i.e., the amount of liquid added is about 2.5 times the weight of the fabric); prepare wet wipes. Fold the wet wipes appropriately, put them into an aluminum foil bag (13.0cm*9.0cm), and seal it.

[0066] The wet wipes were stored at room temperature for 23 days without solid precipitation; they were stored in a refrigerator (2-8°C) for 23 days without solid precipitation.

[0067] According to GB15979-2002 "Hygiene Standards for Disposable Hygiene Products", the sterilization rate of wet wipes was tested by Suzhou Customs Comprehensive Technology Center. When the test temperature is 25℃±1℃, the sample has a sterilization effect on the experimental bacteria (Escherichia coli, Staphylococcus aureus) for 2 minutes or more, and the sterilization rate for Escherichia coli is greater than 99.9%, and the sterilization rate for Staphylococcus aureus is greater than 99.9%.

[0068] Example 9

[0069]

[0070]

[0071] Prepare the liquid composition for disinfection: take anhydrous ethanol into the liquid preparation container, add EGCG palmitate and stir to dissolve, continue to add benzalkonium chloride, propylene glycol, aloe extract, aqueous green tea essence and stir evenly, finally add purified water and stir evenly until a clear and transparent solution is obtained. The final liquid density is about 0.865g / mL.

[0072] Preparation of wet wipes: Take 60g of non-woven fabric and cut each piece into a size of about 17.5cm*15.0cm (about 1.5g / piece); use a syringe to evenly add the disinfectant liquid composition to the non-woven fabric, the amount of which is about 4.50g / piece (i.e., the amount of liquid added is about 3 times the weight of the fabric); prepare wet wipes (prepare the liquid according to the amount required for 60 pieces, and actually prepare 50 wet wipes). Fold the wet wipes appropriately, put them into an aluminum foil bag (13.0cm*9.0cm), and seal it.

[0073] Several batches of wet wipes were prepared, and 100 samples were sent to the testing unit (Guangdong Microbiological Analysis and Testing Center) for testing in accordance with the 2002 edition of the "Technical Specifications for Disinfection". The wet wipes squeezed liquid was used as the test stock solution, and the average virus inactivation rate for mouse norovirus was 95.24%. The wet wipes have a killing effect on non-enveloped viruses such as norovirus.

[0074] Several batches of wet wipes were prepared, and 100 samples were sent to the testing unit (Guangdong Microbiological Analysis and Testing Center) for testing according to the 2002 edition of the "Technical Specifications for Disinfection". The wet wipes squeezed liquid was used as the test stock solution, and the average virus inactivation rate for influenza A virus (H1N1: A / PR / 8 / 34) was greater than 99.99%. The wet wipes have a killing effect on influenza A.

[0075] Example 10

[0076] Refer to Example 9 to prepare a liquid composition for disinfection.

[0077] Prepare wet wipes with reference to Example 9, with the amount of liquid added being about 5.25 g / piece (i.e., the amount of liquid added being about 3.5 times the weight of the cloth).

[0078] Embodiment 11

[0079] Material Name Ratio / %(w / w) EGCG Palmitate 0.12 Propylene glycol 5.78 Benzalkonium chloride 0.23 Aloe Vera Extract 7.51 Water-based green tea flavor 0.58 Ethanol 67.97 Purified water 17.81 Total 100.00

[0080] Prepare a liquid composition for disinfection: take anhydrous ethanol into a liquid preparation container, add EGCG palmitate and stir to dissolve, continue to add benzalkonium chloride, propylene glycol, aloe extract, and aqueous green tea essence and stir evenly, and finally add purified water and stir evenly until a clear and transparent solution is obtained.

[0081] Preparation of wet wipes: Take non-woven fabric (60g specification), spray the liquid composition for disinfection evenly on the non-woven fabric (the amount of liquid sprayed is 2.5 to 3 times the weight of the fabric), and then cut the wet wipes on the production line to a size of 17.5cm*15.0cm and package and seal.

[0082] All documents mentioned in the present invention are cited as references in this application, just as each document is cited as reference separately. In addition, it should be understood that after reading the above content of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the claims attached to this application.

Claims

1. A liquid composition for disinfection, comprising EGCG monopalmitate, ethanol and water; The mass percentage of the EGCG monopalmitate is 0.05-0.5%; The mass percentage of the ethanol is 57% to 74%; The EGCG monopalmitate is selected from one, two, three or four of the compounds of formula Ia, Ib, Ic and Id; 。 2. The liquid composition according to claim 1, characterized in that The composition also includes a quaternary ammonium salt; The quaternary ammonium salt is a chloride-type quaternary ammonium salt and / or a bromide-type quaternary ammonium salt; The mass percentage of the quaternary ammonium salt is 0.05% to 0.3%.

3. The liquid composition according to claim 1, characterized in that The composition also includes a humectant; The moisturizing agent is selected from one or more of glycerin, propylene glycol, sorbitol, butylene glycol, polyethylene glycol, sodium hyaluronate, and panthenol; The mass percentage of the moisturizing agent is 4% to 16% or 5% to 10% or 10% to 15%.

4. The liquid composition according to claim 1, characterized in that The composition also includes a preservative; The preservative is selected from one or more of methyl parahydroxybenzoate, sodium methyl parahydroxybenzoate, ethyl parahydroxybenzoate, sodium ethyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium propyl parahydroxybenzoate, benzoic acid, sodium benzoate, potassium metabisulfite, sodium metabisulfite, sodium sulfite, sodium bisulfite, sodium hyposulfite, ε-polylysine, ε-polylysine hydrochloride, sorbic acid, and potassium sorbate; The mass of the preservative is 0.25 to 2 times or 0.5 to 1 times that of EGCG monopalmitate.

5. The liquid composition according to claim 1, characterized in that The composition also includes a skin care agent; The skin care agent is selected from aloe extract, chamomile extract, Centella asiatica extract, and honeysuckle extract; The mass percentage of the skin care agent is 1% to 10% or 5% to 15%.

6. The liquid composition according to claim 1, characterized in that The composition also includes a flavoring agent; The flavoring agent is a water-soluble flavor; The mass of the flavor enhancer is 1 to 8 times or 2 to 10 times that of EGCG monopalmitate.

7. The liquid composition according to any one of claims 1 to 6, characterized in that The mass percentage of the EGCG monopalmitate is 0.1% to 0.3% or 0.1% to 0.25% or 0.15% to 0.3% or 0.1% to 0.2% or 0.2% to 0.3%; Preferred concentrations are 0.1%, 0.12%, 0.15%, 0.2%, or 0.25%.

8. The liquid composition according to any one of claims 1 to 6, characterized in that The EGCG monopalmitate is a compound of formula Ia.

9. The liquid composition according to any one of claims 1 to 6, characterized in that The mass percentage of the ethanol is 57% to 69% or 62% to 74% or 67% to 71%.

10. A wet wipe comprising the liquid composition according to any one of claims 1 to 9, and a carrier; The carrier is selected from nonwoven fabric, fabric, wood pulp composite fabric or wood pulp paper.

11. Use of the liquid composition according to any one of claims 1 to 9 or the wet wipes according to claim 10, characterized in that: Used to inactivate microorganisms.

12. The use according to claim 11, characterized in that: The microorganism is selected from enveloped viruses and / or non-enveloped viruses.

13. The use according to claim 11, characterized in that: The microorganism is selected from vesicular stomatitis virus (VSV), human immunodeficiency virus (HIV), influenza A virus (IAV), enterovirus 71, adenovirus (AdV), hepatitis B virus (HBV), herpes simplex virus type 1 and 2 (HSV-1 and -2), hepatitis C virus (HCV), SARS-Cov-2, and norovirus.

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