SPECT imaging device, SPECT imaging system and diagnostic combination

Abstract

The invention discloses an SPECT imaging device, an SPECT imaging system and a diagnosis combination. The SPECT imaging device comprises a rack and a nuclear detector group. The rack is provided with a through hole for a detected object to pass through. The through hole has a central axis. The nuclear detector group is arranged on the end face of the rack and comprises a plurality of longitudinal detectors arranged on the upper side and the lower side of the central axis and a plurality of transverse detectors arranged on the left side and the right side of the central axis, and the longitudinal detectors are used for obtaining longitudinal images of a detected object; the plurality of transverse detectors are used for acquiring a transverse image of the detected object, and the distance between the longitudinal detector and the central axis is smaller than that between the transverse detectors and the central axis. According to the SPECT imaging device, the collection efficiency is improved, the sensitivity is improved, and the resolution ratio of a detection image is improved.

Description

[0001] This application is a divisional application based on the invention application with application number 202310995766.7, application date August 9, 2023, applicant Foshan Radio Medical Systems Co., Ltd., and invention name "SPECT imaging device, SPECT imaging system and diagnostic combination". Technical Field

[0002] The invention relates to a SPECT imaging device, a SPECT imaging system and a diagnosis combination. Background Art

[0003] The SPECT imaging system (SPECT, Single-Photon Emission Computed Tomography) is a single-photon emission computed tomography device that detects the absorption distribution of radioactive drugs in the patient's body, displays the metabolic activity of the examined organs or tissues, and realizes nuclear medicine clinical imaging judgment.

[0004] In the related art, the SPECT imaging system includes two detectors arranged symmetrically or adjacently. When examining a patient, it is necessary to rotate around the patient's body once to obtain complete sampling data for image reconstruction. This will result in a long scanning time and reduce the inspection efficiency.

[0005] It should be noted that the statements in this background technology section only provide background technology related to the present invention and do not necessarily constitute prior art. Summary of the invention

[0006] The invention provides a SPECT imaging device, a SPECT imaging system and a diagnosis combination to improve the resolution and detection sensitivity of the detection image.

[0007] A first aspect of the present invention provides a SPECT imaging device, comprising:

[0008] A frame, the frame having a through hole for the detected object to pass through, the through hole having a central axis; and

[0009] A nuclear detector group is arranged on the end face of the frame, and the nuclear detector group includes a plurality of longitudinal detectors arranged on the upper and lower sides of the central axis and a plurality of transverse detectors arranged on the left and right sides of the central axis. The plurality of longitudinal detectors are used to obtain longitudinal images of the detected object, and the plurality of transverse detectors are used to obtain transverse images of the detected object. The distance between the longitudinal detector and the central axis is smaller than the distance between the transverse detector and the central axis.

[0010] In some embodiments, in the circumferential direction of the distribution of the nuclear detector groups, the scanning range covered by the longitudinal detectors is greater than the scanning range covered by the transverse detectors.

[0011] In some embodiments, the number of longitudinal detectors is 2 to 10, preferably 2, 4, or 6; and / or the number of transverse detectors is 2 to 8, preferably 2 or 4.

[0012] In some embodiments, the gantry is configured not to rotate; or, the gantry is configured to rotate less than 90° around the central axis to complete the truncated scanning detection of the detected object.

[0013] In some embodiments, the longitudinal detector is configured to be movably disposed in a radial direction to approach the object to be detected; and / or the transverse detector is configured to be movably disposed in a radial direction to approach the object to be detected.

[0014] In some embodiments, the multiple longitudinal detectors include a first longitudinal detector and a second longitudinal detector, the working surface of the first longitudinal detector is parallel or inclined relative to the transverse axis, the working surface of the second longitudinal detector is parallel to the transverse axis, and the transverse axis is perpendicular to the central axis and extends in the transverse direction.

[0015] In some embodiments, the angle between the working surface of the first longitudinal detector and the working surface of the second longitudinal detector is 0° to 60°, preferably 0° to 30°.

[0016] In some embodiments, the multiple lateral detectors include a first lateral detector and a second lateral detector, wherein the working surface of the first lateral detector is parallel to or inclined relative to the longitudinal axis, and the working surface of the second lateral detector is inclined relative to the longitudinal axis, and the longitudinal axis is perpendicular to the central axis and extends in the longitudinal direction.

[0017] In some embodiments, the angle between the working surface of the first transverse detector and the working surface of the second transverse detector is 0° to 60°, preferably 0° to 30°.

[0018] In some embodiments, multiple longitudinal detectors include a first longitudinal detector and a second longitudinal detector, the working surface of the first longitudinal detector is tilted relative to the transverse axis, and the working surface of the second longitudinal detector is tilted relative to the transverse axis. Multiple transverse detectors include a first transverse detector and a second transverse detector, the working surface of the first transverse detector is tilted relative to the longitudinal axis, wherein the working surface of the second transverse detector is tilted relative to the longitudinal axis, and the longitudinal axis, the transverse axis and the center axis are perpendicular to each other.

[0019] In some embodiments, the angle of the working surface of the longitudinal detector is adjustable; or, the angle of the working surface of the transverse detector is adjustable.

[0020] In some embodiments, the detectors of the nuclear detector group include large-area continuous sodium iodide crystals or regular-volume cesium iodide crystals; or, the detectors of the nuclear detector group include sodium iodide crystals and coupled photoelectric devices, which are bonded to the back of the sodium iodide crystals, and the photoelectric devices include photomultiplier tube (PMT) arrays or silicon photomultiplier tubes; or, the detectors of the nuclear detector group include cesium iodide crystals and coupled photoelectric devices, which are bonded to the back of the sodium iodide crystals, and the photoelectric devices include photomultiplier tube (PMT) arrays or silicon photomultiplier tubes.

[0021] In some embodiments, the ratio between the width of the longitudinal detector and the width of the transverse detector is (1-3):(1-2); preferably (1.5-2.5):1; or, the longitudinal detector includes a longitudinal probe array, and the longitudinal probe array is arranged in a (4-16)*(4-16) manner; preferably (8-12)*(8-12); or, the transverse detector includes a transverse probe array, and the transverse probe array is arranged in a (6-10)*(6-10) manner.

[0022] In some embodiments, the distance between the detector of the nuclear detector group and the detected object is 2 to 250 mm, preferably 2 to 10 mm or 10 to 180 mm; or, the distance between the projection point of the rotation center on the lateral detector and the center line of the lateral detector is 10-25 mm and 25-40 mm, respectively, and does not change with the angle.

[0023] In some embodiments, the gantry is configured to rotate in steps between -30° and 30° around the central axis. Preferably, the distance between the detectors of the nuclear detector group and the detected object is constantly set to 15 mm.

[0024] A second aspect of the present invention provides a SPECT imaging system, comprising the above-mentioned SPECT imaging device and a control system, wherein the control system comprises:

[0025] A self-check module, used for adapting to different protocols before diagnosis and for determining the collimator type, energy window combination, retrieval type, injection time and injection dose;

[0026] The detection module is used to control the starting angle and the ending angle of the rack, and is used to select a fixed position mode or a closest human body distance mode. The detection module is also configured to control the rack to rotate to a set angle, control the detector to move to a set distance, control the detector to rotate to a set angle and scan according to a preset scanning mode after the scanning starts. The detection module is also configured to determine whether to end the scanning according to a "time count" or a "total event count" or a "gated count".

[0027] In some embodiments, the control system also includes a supplementary scanning module, which is used to verify the scanning effect, including the scanning completion degree and resolution. The supplementary scanning module is also used to determine whether to perform supplementary scanning based on the verification result and determine the supplementary scanning angle and supplementary scanning distance based on the verification result, and the supplementary scanning module is configured to control the detection module to perform supplementary scanning; alternatively, the control system also includes a reset module, which is used to move the detector to the maximum outer diameter and control the frame to rotate to the 0° position.

[0028] The third aspect of the present invention provides a diagnostic combination, comprising the above-mentioned SPECT imaging system and a SPECT diagnostic drug.

[0029] In some embodiments, the administration dose of the SPECT diagnostic drug is 0.1-1mCi / kg, preferably 0.1-0.5mCi / kg, more preferably 0.1mCi / kg, 0.2mCi / kg, 0.3mCi / kg, 0.4mCi / kg, 0.5mCi / kg; or, the single case detection time of the diagnostic combination is 5-60 minutes, preferably 5-50 minutes, 5-40 minutes, 5-45 minutes, 10-45 minutes, 15-45 minutes, 15-30 minutes, 15-20 minutes, more preferably 5 minutes, 10 minutes, 15 minutes, 20 minutes, 25 minutes.

[0030] Based on the technical solution provided by the present invention, the SPECT imaging device includes a frame and a nuclear detector group. The frame has a through hole for the object to be detected to pass through. The through hole has a central axis. The nuclear detector group is arranged on the end face of the frame, and the nuclear detector group includes a plurality of longitudinal detectors arranged on the upper and lower sides of the central axis and a plurality of transverse detectors arranged on the left and right sides of the central axis, the plurality of longitudinal detectors are used to obtain longitudinal images of the object to be detected, the plurality of transverse detectors are used to obtain transverse images of the object to be detected, and the distance between the longitudinal detector and the central axis is less than the distance between the transverse detector and the central axis. The SPECT imaging device of the embodiment of the present invention sets the distance between the upper and lower longitudinal detectors to be smaller and to have an angle, and sets the distance between the left and right transverse detectors to be larger and to have an angle. Such an asymmetric setting makes the circumferential distribution of multiple detectors roughly form an ellipse, which is consistent with the cross-sectional shape of the patient's body, thereby making the distance between the longitudinal detectors located on the upper and lower sides of the patient closer to the patient's body, and the irregular trapezoid formed by the upper and lower longitudinal detectors and the left and right transverse detectors can collect more photon counts in different directions; by using the upper and lower large longitudinal detectors as close to the human body as possible to obtain the best sensitivity, the longitudinal non-truncation data is obtained, and by using the left and right transverse small detectors as an auxiliary to supplement the resolution, the transverse sampling angle data is obtained, thereby improving the resolution and detection sensitivity of the detection image.

[0031] The asymmetric detector design of the present invention and the flexible adjustment of the detector angle and distance can better fit the patient's contour, and can realize single-bed scanning without fully rotating 360 degrees or even without rotation, and can achieve the goal of fully sampling the distribution of radioactive drugs, and realize the dynamic fast tomography function, which can shorten the detection time of whole-body scanning to less than 15 minutes, greatly shorten the clinical detection time, and improve the overall operation efficiency of the equipment. It avoids the frequent radial movement and rotation of the detector during the detection process, and the problem that the detector cannot be fully utilized and the detection efficiency is low due to the gap between different detectors, effectively improves the utilization efficiency of the detector, and can effectively solve the problem that the sodium iodide or cesium iodide crystal detector is thick and cannot be fully rotated at all angles in actual production, which not only saves costs, but also improves the detection sensitivity and resolution.

[0032] Based on the above structure and the beneficial effects produced, the SPECT imaging system of the present invention significantly reduces the detection time and dosage of nuclear medicine for a single case in clinical applications, reduces systemic toxic side effects on patients, reduces detection costs, and improves the accessibility of detection equipment.

[0033] Further features and advantages of the present invention will become apparent from the following detailed description of exemplary embodiments of the present invention with reference to the attached drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] The drawings described herein are used to provide a further understanding of the present invention and constitute a part of this application. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings:

[0035] Figure 1 Schematic diagram of the three-dimensional structure of a SPECT device according to some embodiments of the present invention.

[0036] Figure 2 Schematic diagram of a simplified structure of a SPECT device according to some embodiments of the present invention.

[0037] Figure 3 This is a schematic diagram of a frame of a SPECT device in some embodiments of the present invention in an initial detection position.

[0038] Figure 4 This is a schematic diagram of a frame of a SPECT device in some embodiments of the present invention at a detection end position.

[0039] Figure 5 FIG. 4 is a front view of a SPECT device according to some embodiments of the present invention.

[0040] Figure 6 FIG. 1 is a schematic diagram of detector deflection of a SPECT device according to a specific embodiment of the present invention.

[0041] Figure 7 This is a process diagram of a SPECT device from an initial detection position to an end detection position according to some embodiments of the present invention.

[0042] Figure 8 FIG. 4 is a diagram of the detection process of a SPECT device according to some embodiments of the present invention. DETAILED DESCRIPTION

[0043] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. The following description of at least one exemplary embodiment is actually only illustrative and is by no means intended to limit the present invention and its application or use. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0044] Unless otherwise specifically stated, the relative arrangement, numerical expressions and numerical values ​​of the parts and steps set forth in these embodiments do not limit the scope of the present invention. Meanwhile, it should be understood that, for ease of description, the sizes of the various parts shown in the accompanying drawings are not drawn according to actual proportional relationships. The technology, methods and equipment known to those of ordinary skill in the relevant art may not be discussed in detail, but in appropriate cases, the technology, methods and equipment should be considered as a part of the specification. In all examples shown and discussed here, any specific value should be interpreted as being merely exemplary, rather than as a limitation. Therefore, other examples of exemplary embodiments may have different values. It should be noted that similar reference numerals and letters represent similar items in the following drawings, and therefore, once a certain item is defined in an accompanying drawing, it does not need to be further discussed in subsequent drawings.

[0045] For ease of description, spatially relative terms such as "above", "above", "on the upper surface of", "above", etc. may be used here to describe the spatial positional relationship between a device or feature and other devices or features as shown in the figure. It should be understood that spatially relative terms are intended to include different orientations of the device in use or operation in addition to the orientation described in the figure. For example, if the device in the accompanying drawings is inverted, the device described as "above other devices or structures" or "above other devices or structures" will be positioned as "below other devices or structures" or "below other devices or structures". Thus, the exemplary term "above" may include both "above" and "below". The device may also be positioned in other different ways, and the spatially relative descriptions used here are interpreted accordingly.

[0046] As mentioned above, the detectors of existing SPECT imaging systems are all arranged symmetrically or adjacently, so in order to ensure the integrity of data sampling, the detectors need to surround the patient's body by at least 180° or 360°.

[0047] However, the inventors of the present application discovered during the research process that when the patient is in the detection position, that is, when the patient is in a supine position, the cross-sectional shape of the body contour is approximately an ellipse. That is to say, the width of the patient's body contour is greater than its thickness. The thickness refers to the distance from the front chest side to the back side of the human body, and the width refers to the distance from the left shoulder side to the right shoulder side of the human body. If a symmetrically arranged detector is used, the distance between the detector and the patient's body will be relatively far when detecting on one side of the patient's body in the thickness direction, which will cause the acquired detection image to be unclear and waste part of the detector in the width direction of the human body.

[0048] For this problem, refer to Figure 1 and Figure 2 The SPECT imaging device provided in the embodiment of the present application includes a frame 12 and a nuclear detector group 20. The frame 12 has a through hole for the object to be detected to pass through. The through hole has a central axis. The nuclear detector group 20 is arranged on the end face of the frame 12, and the nuclear detector group 20 includes a plurality of longitudinal detectors arranged on the upper and lower sides of the central axis and a plurality of transverse detectors arranged on the left and right sides of the central axis. The plurality of longitudinal detectors are used to obtain longitudinal images of the object to be detected, and the plurality of transverse detectors are used to obtain transverse images of the object to be detected. The distance between the longitudinal detector and the central axis is smaller than the distance between the transverse detector and the central axis. The SPECT imaging device of the embodiment of the present invention sets the distance between the upper and lower longitudinal detectors to be smaller and to have an angle, and sets the distance between the left and right lateral detectors to be larger and to have an angle. Such an asymmetric setting enables the multiple detectors to form an irregular quadrilateral, and the circumferential distribution when rotated during the examination roughly forms an ellipse, which is consistent with the cross-sectional shape of the patient's body, thereby making the distance between the longitudinal detectors located on the upper and lower sides of the patient and the patient's body closer, and by using the upper and lower large longitudinal detectors as close to the human body as possible to obtain the best sensitivity, longitudinal non-truncation data is obtained, and by using the left and right lateral small detectors as auxiliary to supplement the resolution, the lateral sampling angle data is obtained, thereby improving the resolution and detection sensitivity of the detection image.

[0049] refer to Figure 1 In some embodiments, the frame 12 is a cylindrical structure. The frame 12 has a through hole extending in the axial direction. A bed plate is arranged in the through hole, and the bed plate is used to make the detection object lie flat. A nuclear detector group 20 is installed on the end face of the axial front end of the frame 12.

[0050] Specifically, the rack 12 includes a rack stator 11 and a rack rotor, and the rack rotor is driven by a driver to rotate around a central axis relative to the rack stator 11. The nuclear detector group 20 is arranged on the rack rotor to rotate under the drive of the rack rotor. The nuclear detector group 20 is used to collect radioactive drugs absorbed and distributed in the patient's body.

[0051] In some embodiments, the number of longitudinal detectors is 2 to 10, preferably 2, 4, or 6. The number of transverse detectors is 2 to 8, preferably 2 or 4. If the number of longitudinal detectors is 4 or more, and the number of transverse detectors is also 4 or more, multiple detectors are respectively arranged up and down or left and right, so that the multiple detectors of the nuclear detector group are distributed irregularly and deformably, which will fit more and more into a complete ellipse and better fit the contour of the human body.

[0052] And in Figure 1 and Figure 2 In a specific embodiment shown, the nuclear detector group 20 is composed of two longitudinal detectors respectively arranged on the upper and lower sides of the central axis and two transverse detectors respectively arranged on the left and right sides of the central axis. The two longitudinal detectors are used to obtain longitudinal images of the object to be detected. The two transverse detectors are used to obtain transverse images of the object to be detected. The distance between the longitudinal detector and the central axis is smaller than the distance between the transverse detector and the central axis.

[0053] In some embodiments, the detector includes sodium iodide crystals or cesium iodide crystals. For example, the detector is a flat panel detector of different sizes composed of sodium iodide crystals or cesium iodide crystals and coupled optoelectronic devices.

[0054] Specifically, the detectors of the nuclear detector group 20 include large-area sodium iodide (NaI) continuous crystals or regular-volume cesium iodide (Csl) crystals.

[0055] The detector of the nuclear detector group 20 includes a sodium iodide crystal and a coupled photoelectric device. The photoelectric device is attached to the back of the sodium iodide crystal. The photoelectric device includes a photomultiplier tube (PMT) array or a silicon photomultiplier tube.

[0056] The detector of the nuclear detector group 20 includes a cesium iodide crystal and a coupled photoelectric device. The photoelectric device is attached to the back of the sodium iodide crystal. The photoelectric device includes a photomultiplier tube (PMT) array or a silicon photomultiplier tube.

[0057] The ratio between the width of the longitudinal detector and the width of the transverse detector is (1-3):(1-2); preferably (1.5-2.5):1. That is, the width of the longitudinal detector is greater than the width of the transverse detector, and the width here refers to the size of the detector in the extension direction of the central axis.

[0058] In some embodiments, the longitudinal detector includes a longitudinal probe array, and the longitudinal probe array is arranged in a (4-16)*(4-16) manner; preferably (8-12)*(8-12).

[0059] In some embodiments, the lateral detector includes a lateral probe array, and the lateral probe array is arranged in a (6-10)*(6-10) manner.

[0060] The nuclear detector group 20 includes a first longitudinal detector 21, a second longitudinal detector 22, a first transverse detector 23, and a second transverse detector 24 arranged in the circumferential direction. The first longitudinal detector 21 is arranged above the object to be detected, the second longitudinal detector 22 is arranged below the object to be detected, the first transverse detector 23 is arranged on the left side of the object to be detected, and the second transverse detector 24 is arranged on the right side of the object to be detected.

[0061] The distance between each of the above detectors and the detected object is 2 to 250 mm, preferably 2 to 10 mm or 10 to 180 mm.

[0062] In other embodiments, the distances between the projection point of the rotation center on the left lateral detector and the center line of the right lateral detector are 10-25 mm and 25-40 mm, respectively, and do not change with angle changes.

[0063] In order to expand the detection range of the nuclear detector group 20 and thus reduce the rotation angle of the rack 12 during the detection process, in some embodiments, in the circumferential direction of the distribution of the nuclear detector group 20, the scanning range covered by the longitudinal detector is greater than the scanning range covered by the transverse detector. Figure 2 From the perspective of the cross-sectional shape, the coverage of the longitudinal detector is greater than that of the transverse detector. Thus, by setting four detectors, the circumferential coverage of the object to be inspected can be basically achieved. Thus, when inspecting the object to be inspected, the rack 12 can be rotated at a relatively small angle without rotating, and a complete image can be obtained, thereby improving the inspection efficiency.

[0064] In some embodiments, the rack 12 is configured not to rotate. Since four detectors can basically cover the entire body, the algorithm can make up for the missed sampling at the corners of the irregular quadrilateral formed by the four detectors, so that static or dynamic scanning can be completed without rotating the rack.

[0065] In other embodiments, the rack 12 is configured to rotate less than 90° around the central axis to complete the truncated scanning detection of the detected object. Since the embodiment of the present application sets four detectors on the circumference of the detected object, and sets the scanning ranges of the two longitudinal detectors to be larger, and the scanning ranges of the two transverse detectors to be smaller, the four detectors can basically achieve full coverage of the circumference of the detected object. Therefore, the detection of the missing angle can be achieved by controlling the rack 12 to rotate a smaller angle.

[0066] refer to Figure 3 , Figure 4 and Figure 7 In some embodiments, the rack 12 has an initial detection position and an end detection position. Figure 3 Shown is the detection initial position. Figure 4 The frame 12 is configured to rotate counterclockwise to reach the detection initial position. Figure 7 The diagram shows the position of the frame 12 and the rotation center at five angles of -30°, -15°, 0°, +15°, and +30°.

[0067] like Figure 7 As shown, the initial detection position of the rack 12 is at -30°. The end detection position of the rack 12 is at +30°. The rack 12 is configured to rotate stepwise between -30° and 30° around the central axis. Preferably, the distance between the detector of the nuclear detector group 20 and the detected object is constantly set to 15 mm.

[0068] In order to improve the adaptability of the SPECT imaging system of the embodiment of the present invention, in some embodiments, the longitudinal detector is configured to be movably arranged in the radial direction to be close to the object to be detected. The radial direction refers to the radial direction of the through hole. For different objects to be detected, such as objects of different fatness and thinness, the longitudinal detector can be moved in the radial direction to be as close to the object to be detected as possible to obtain a clearer detection image.

[0069] Furthermore, in some other embodiments, the transverse detector is configured to be movably arranged in the radial direction to be close to the detected object. For example, for children and adults, the transverse width of children is narrower than that of adults, and a clearer detection image can be obtained by moving the transverse detector in the radial direction to be as close to the detected object as possible.

[0070] In some embodiments, a servo motor drives a lead screw or a synchronous belt to drive the detector to move radially to push or pull the detector closer to the human body contour to improve the resolution and sensitivity of key parameters.

[0071] In some embodiments, the two longitudinal detectors include a first longitudinal detector 21 and a second longitudinal detector 22. The detection surface of the first longitudinal detector 21 is tilted relative to the transverse axis x, and the detection surface of the second longitudinal detector 22 is parallel to the transverse axis, which is perpendicular to the central axis and extends in the transverse direction.

[0072] The detection surface of the first longitudinal detector 21 of the embodiment of the present invention is arranged to be inclined relative to the transverse axis, and the detection surface of the second longitudinal detector 22 is arranged to be parallel to the transverse direction. That is to say, the first longitudinal detector 21 and the second longitudinal detector 22 are arranged asymmetrically, thereby expanding the detection range of the first longitudinal detector 21, so that the frame 12 does not need to rotate 360° or even does not need to rotate to achieve the goal of fully sampling the distribution of radioactive drugs, thereby improving the sampling efficiency.

[0073] It should be noted that the detection surface of the detector refers to the surface of the detector that is close to the object to be detected and is used to receive radiation. Figure 5 In the illustrated embodiment, the detector is a square structure. The detection surface refers to the side of the square structure close to the object to be detected. Figure 5 In the state shown, for the first longitudinal detector 21, its detection surface is its bottom surface. For the second longitudinal detector 22, its detection surface is the top surface. For the first transverse detector 23, its detection surface is the right side surface. For the second transverse detector 24, its detection surface is the left side surface.

[0074] In some embodiments, the angle α between the detection surface of the first longitudinal detector 21 and the detection surface of the second longitudinal detector 22 is 0° to 60°. Preferably, α is 0° to 30°.

[0075] In some other embodiments not shown in the drawings, the detection surface of the second longitudinal detector 22 has an angle with the transverse axis x. In this case, the angle γ between the detection surface of the first longitudinal detector 21 and the second longitudinal detector 22 is greater than α.

[0076] In some embodiments, the two transverse detectors include a first transverse detector 23 and a second transverse detector 24. The detection surface of the first transverse detector 23 is tilted relative to the longitudinal axis y, and the detection surface of the second transverse detector 24 is tilted relative to the longitudinal axis y, and the longitudinal axis y is perpendicular to the central axis and extends in the longitudinal direction.

[0077] like Figure 5 As shown, the angle β between the detection surface of the first transverse detector 23 and the longitudinal axis y is greater than the angle b between the detection surface of the second transverse detector 24 and the longitudinal axis y. The angle θ between the detection surface of the first transverse detector 23 and the detection surface of the second transverse detector 24 is β+b.

[0078] In some embodiments, the angle β between the detection surface of the first transverse detector 23 and the second transverse detector 24 is 0° to 60°. β is 0° to 30°.

[0079] Preferably, the angle α between the detection surface of the first longitudinal detector 21 and the transverse axis x is 2-10°. The angle β between the detection surface of the first transverse detector 23 and the longitudinal axis y is 6-14°. The angle b between the detection surface of the second transverse detector 24 and the longitudinal axis y is 1-6°.

[0080] In a specific embodiment, Figures 5 and 6 As shown, the two longitudinal detectors include a first longitudinal detector 21 and a second longitudinal detector 22. The detection surface of the first longitudinal detector 21 is tilted relative to the transverse axis, and the detection surface of the second longitudinal detector 22 is parallel to the transverse axis. The two transverse detectors include a first transverse detector 23 and a second transverse detector 24, wherein the detection surface of the first transverse detector 23 is tilted relative to the longitudinal axis, and the detection surface of the second transverse detector 24 is tilted relative to the longitudinal axis, wherein the transverse axis x, the longitudinal axis y and the central axis are perpendicular to each other. The angle α between the detection surface of the first longitudinal detector 21 and the transverse axis x is 6°. The angle β between the detection surface of the first transverse detector 23 and the longitudinal axis y is 8°. The angle b between the detection surface of the second transverse detector 24 and the longitudinal axis y is 2°. Under the above preferred angles, the minimum gap between each detector and the human body contour can be achieved, thereby improving parameter resolution and sensitivity. Under the above preferred angles, after the rotation of the rack 12, the detectors are allowed to cover as many angles as possible, rather than only obtaining redundant data.

[0081] In some embodiments, the angle of the working surface of the longitudinal detector is adjustable. By adjusting the angle of the working surface of the longitudinal detector, photon detection images at more angles, especially non-repetitive angles, can be obtained, thereby obtaining a more comprehensive inspection result. By adjusting the angle of the working surface of the longitudinal detector, the gap left at the angle between adjacent detectors can be covered, and the clinical scan of the human body truncated by a single bed can be maximized without changing any rotation angle.

[0082] Specifically, a servo motor or stepper motor drives a lead screw or a synchronous belt with a mechanical mechanism such as a gear to make the detector swing left or right around the center line at a small angle to adjust the reception of gamma photons from different angles and maximize data collection.

[0083] Specifically, the longitudinal detector is configured to be rotatable around its own axis to adjust the angle of its working surface.

[0084] In other embodiments, the angle of the working surface of the lateral detector is adjustable. Similarly, the adjustable angle of the working surface of the lateral detector enables the SPECT imaging system of the embodiment of the present invention to selectively obtain photon detection images at more angles. By adjusting the angle of the working surface of the lateral detector, it is possible to cover the gap left at the angle between adjacent detectors, and maximize the clinical scan of a single bed without changing any rotation angle to cover the human body truncation of the bed.

[0085] In some other embodiments, the angle of the working surface of the transverse detector is fixed. Alternatively, the angle of the working surface of the longitudinal detector is fixed.

[0086] High-sensitivity collimators can be optionally installed in the four detectors. In the reconstruction algorithm, different weights are used for the data of different detectors, so that low-noise images or high-resolution images can be obtained according to different clinical needs. The SPECT imaging system of the embodiment of the present invention automatically adjusts the data weights of collimators of different resolutions according to the different imaging needs of different organs, thereby achieving a balance between field of view, sensitivity and resolution.

[0087] In some embodiments, Figure 6 As shown, the distances between the projection points of the rotation center on the left and right lateral detectors and the center lines of the left and right lateral detectors are 16.72 mm and 33.33 mm, respectively, and do not change with the angle.

[0088] like Figure 8 As shown, the present invention also provides a SPECT imaging system, comprising the above-mentioned SPECT imaging device and a control system, wherein the control system comprises:

[0089] A self-check module, used for adapting to different protocols before diagnosis and for determining the collimator type, energy window combination, retrieval type, injection time and injection dose;

[0090] The detection module is used to control the starting angle and the ending angle of the rack, and is used to select a fixed position mode or a closest human body distance mode. The detection module is also configured to control the rack to rotate to a set angle, control the detector to move to a set distance, control the detector to rotate to a set angle and scan according to a preset scanning mode after the scanning starts. The detection module is also configured to determine whether to end the scanning according to a "time count" or a "total event count" or a "gated count".

[0091] In some embodiments, the control system further includes a supplementary scanning module. The supplementary scanning module is used to check the scanning effect, including the scanning completion degree and resolution. The supplementary scanning module is also used to determine whether to perform supplementary scanning according to the verification result and determine the supplementary scanning angle and the supplementary scanning distance according to the verification result, and the supplementary scanning module is configured to control the detection module to perform supplementary scanning. The SPECT imaging system of the embodiment of the present invention performs supplementary scanning when it is determined that supplementary scanning is needed by setting the supplementary scanning module, and determines the supplementary scanning angle and the supplementary scanning distance according to the verification result during the supplementary scanning, so that all-round scanning can be avoided and efficiency can be further improved.

[0092] The control system further comprises a reset module, which is used for moving the detector to the maximum outer diameter and controlling the rack to rotate to the 0° position.

[0093] The present invention also provides a diagnostic combination, comprising the above-mentioned SPECT imaging system and SPECT diagnostic drugs.

[0094] In some embodiments, the administration dose of the SPECT diagnostic drug is 0.1-1mCi / kg, preferably 0.1-0.5mCi / kg, more preferably 0.1mCi / kg, 0.2mCi / kg, 0.3mCi / kg, 0.4mCi / kg, 0.5mCi / kg; or, the single case detection time of the diagnostic combination is 5-60 minutes, preferably 5-50 minutes, 5-40 minutes, 5-45 minutes, 10-45 minutes, 15-45 minutes, 15-30 minutes, 15-20 minutes, more preferably 5 minutes, 10 minutes, 15 minutes, 20 minutes, 25 minutes.

[0095] An example of clinical testing using a diagnostic combination according to an embodiment of the present invention is shown below.

[0096] The patient is 184cm tall and weighs 85kg. With his arms raised, the widest part of his shoulders is approximately 410mm and his chest is approximately 250mm thick.

[0097] When testing, refer to Figure 8 ,

[0098] When the SPECT system is powered on, the main control and image processing computers start automatically; the user or operating technician can choose patients for pre-registration and register the patient information to be examined in advance, or choose patient registration and register the patient's basic information on site; then the SPECT scan data collection will be formally carried out.

[0099] First, start the self-check module, select the corresponding organ protocol and bed position, enter the system inspection interface, and for different protocols such as static scanning acquisition, click on its parameter interface to set the installed collimator type such as high-energy general, energy window combination, the type of radionuclide injected by the patient such as Tc-99m, injection time and injection dose, and other information.

[0100] Then the detection module is started, and the starting angle to the end angle of the SPECT frame rotation are set, and the proximity mode of the detector is set, such as defining the FD mode (Fixed Distance) as the fixed distance between the detector and the human body contour, such as 10-180mm, and the AB mode (As close as possible to body) as the closest distance between the detector and the human body contour, such as 2-10mm; set the starting position to the end position of the bed, execute the bed transfer button to send the patient to the scanning bed, click to start scanning, the SPECT frame rotates to the set angle, and the detector moves to the set distance; if it has a variable angle, the detector swings to the set angle, such as 0-30°, and the above speeds can be configured through the lower computer firmware; finally, the SPECT acquisition stops or ends the acquisition according to different counting methods such as time counting, total event counting or gated counting.

[0101] After the acquisition is completed, it is determined whether additional scanning angles are needed based on the scanning effect. The scan supplement module can be started, the detection module can be called to rescan, or the missing angles can be automatically supplemented according to dynamic acquisition to achieve sufficient data acquisition.

[0102] Finally, the reset module automatically resets the lower computer to the reset state, first moving the detector to the maximum outer diameter position, and then rotating the SPECT rack to the set 0° position.

[0103] Using this SPECT imaging system, the total detection time is 15 minutes. Compared with traditional equipment, it is highly integrated and intelligent, more convenient to operate, and better fits the patient's contours. The intelligent judgment of the comprehensive supplementary scanning module effectively reduces the total detection time, reduces the use of SPECT diagnostic drugs, and effectively reduces the burden on patients.

[0104] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, ordinary technicians in the field should understand that the specific implementation methods of the present invention can still be modified or some technical features can be replaced by equivalents without departing from the spirit of the technical solution of the present invention, which should be included in the scope of the technical solution for protection of the present invention.

Claims

1. A SPECT imaging device, characterized in that: include: A frame (12), the frame (12) having a through hole for the detected object to pass through, the through hole having a central axis; and A nuclear detector group (20) is arranged on the end surface of the frame (12), and the nuclear detector group (20) comprises a first longitudinal detector (21) and a second longitudinal detector (22) respectively arranged on the upper and lower sides of the central axis, and a first transverse detector (23) and a second transverse detector (24) respectively arranged on the left and right sides of the central axis, the first longitudinal detector (21) and the second longitudinal detector (22) are used to obtain a longitudinal image of the detected object, the first transverse detector (23) and the second transverse detector (24) are used to obtain a transverse image of the detected object, an angle is set between the first longitudinal detector (21) and the second longitudinal detector (22), and an angle is set between the first transverse detector (23) and the second transverse detector (24) so ​​that the nuclear detector group forms an irregular quadrilateral.

2. The SPECT imaging device according to claim 1, characterized in that: The distance between the longitudinal detector and the central axis is smaller than the distance between the transverse detector and the central axis.

3. The SPECT imaging device according to claim 1, characterized in that: In the circumferential direction of the distribution of the nuclear detector group (20), the scanning range covered by the longitudinal detector is larger than the scanning range covered by the transverse detector, so that when inspecting the object to be inspected, the frame (12) does not rotate or rotates less than 90 degrees around the central axis to obtain an all-round inspection of the object to be inspected.

4. The SPECT imaging device according to any one of claims 1 to 3, characterized in that: The longitudinal detector is configured to be movably disposed in a radial direction to approach the object to be detected; and / or the transverse detector is configured to be movably disposed in a radial direction to approach the object to be detected.

5. The SPECT imaging device according to any one of claims 1 to 4, characterized in that: The working surface of the first longitudinal detector (21) is arranged parallel to or inclined with respect to the transverse axis (x), the working surface of the second longitudinal detector (22) is parallel to the transverse axis, and the transverse axis (x) is perpendicular to the central axis and extends in the transverse direction.

6. The SPECT imaging device according to claim 5, characterized in that: The angle (α) between the working surface of the first longitudinal detector (21) and the working surface of the second longitudinal detector (22) is 0° to 60°, preferably 0° to 30°.

7. The SPECT imaging device according to any one of claims 1 to 6, characterized in that: The working surface of the first transverse detector (23) is arranged parallel to or inclined relative to the longitudinal axis (y), and the working surface of the second transverse detector (24) is arranged inclined relative to the longitudinal axis (y). The longitudinal axis (y) is perpendicular to the central axis and extends in the longitudinal direction.

8. The SPECT imaging device according to claim 7, characterized in that: The angle (β) between the working surface of the first transverse detector (23) and the working surface of the second transverse detector (24) is 0° to 60°, preferably 0° to 30°.

9. The SPECT imaging device according to any one of claims 1 to 8, characterized in that: The working surface of the first longitudinal detector (21) is tilted relative to the transverse axis, the working surface of the second longitudinal detector (22) is tilted relative to the transverse axis (x), the working surface of the first transverse detector (23) is tilted relative to the longitudinal axis (y), wherein the working surface of the second transverse detector (24) is tilted relative to the longitudinal axis (y), and the longitudinal axis, the transverse axis and the central axis are perpendicular to each other.

10. The SPECT imaging device according to any one of claims 1 to 9, characterized in that: The angle of the working surface of the longitudinal detector is adjustable; or the angle of the working surface of the transverse detector is adjustable.

11. The SPECT imaging device according to any one of claims 1 to 10, characterized in that: The detector of the nuclear detector group (20) comprises a large-area sodium iodide (NaI) continuous crystal or a regular-volume cesium iodide (Csl) crystal; or, the detector of the nuclear detector group (20) comprises a sodium iodide crystal and a coupled photoelectric device, the photoelectric device is bonded to the back of the sodium iodide crystal, and the photoelectric device comprises a photomultiplier tube (PMT) array or a silicon photomultiplier tube; or, the detector of the nuclear detector group (20) comprises a cesium iodide crystal and a coupled photoelectric device, the photoelectric device is bonded to the back of the cesium iodide crystal, and the photoelectric device comprises a photomultiplier tube (PMT) array or a silicon photomultiplier tube.

12. The SPECT imaging device according to any one of claims 1 to 11, characterized in that: The ratio between the width of the longitudinal detector and the width of the transverse detector is (1-3):(1-2), preferably (1.5-2.5):1; and / or, the longitudinal detector includes a longitudinal probe array, and the longitudinal probe array is arranged in a (4-16)*(4-16) manner, preferably in a (8-12)*(8-12) manner; and / or, the transverse detector includes a transverse probe array, and the transverse probe array is arranged in a (6-10)*(6-10) manner.

13. The SPECT imaging device according to any one of claims 1 to 12, characterized in that: The distance between the detector of the nuclear detector group (20) and the detected object is 2-250 mm, preferably 2-10 mm or 10-180 mm; or, the distance between the projection point of the rotation center on the left lateral detector and the center line of the right lateral detector is 10-25 mm, 25-40 mm, respectively, and does not change with the angle.

14. The SPECT imaging device according to any one of claims 1 to 13, characterized in that: The frame (12) is configured to rotate in steps between -30° and 30° around the central axis; preferably, the distance between the detectors of the nuclear detector group (20) and the detected object is constantly set to 15 mm.

15. A SPECT imaging system, characterized in that: The method comprises a SPECT imaging device and a control system according to any one of claims 1 to 14, wherein the control system comprises: A self-check module, used for adapting to different protocols before diagnosis and for determining the collimator type, energy window combination, retrieval type, injection time and injection dose; The detection module is used to control the starting angle and the ending angle of the rack, and is used to select a fixed position mode or a closest human distance mode. The detection module is also configured to control the rack to rotate to a set angle, control the detector to move to a set distance, control the detector to rotate to a set angle and scan according to a preset scanning mode after the scanning starts. The detection module is also configured to determine whether to end the scanning according to "time count" or "total event count" or "gated count".

16. The SPECT imaging system according to claim 15, characterized in that: The control system also includes a supplementary scanning module, which is used to verify the scanning effect, and the scanning effect includes the scanning completion degree and the resolution. The supplementary scanning module is also used to determine whether to perform supplementary scanning according to the verification result and determine the supplementary scanning angle and the supplementary scanning distance according to the verification result, and the supplementary scanning module is configured to control the detection module to perform supplementary scanning; or, the control system also includes a reset module, which is used to move the detector to the maximum outer diameter and control the frame to rotate to the 0° position.

17. A diagnostic combination, characterized in that It comprises the SPECT imaging system as claimed in claim 15 or 16 and a SPECT diagnostic drug.

18. The diagnostic combination according to claim 17, characterized in that The administration dosage of the SPECT diagnostic drug is 0.1-1 mCi / kg; or, the single case detection time of the diagnostic combination is 5-60 minutes.

19. The diagnostic combination according to claim 18, characterized in that The administration dosage of the SPECT diagnostic drug is 0.1-0.5 mCi / kg; or, the single case detection time of the diagnostic combination is one of 5-50 minutes, 5-40 minutes, 5-45 minutes, 10-45 minutes, 15-45 minutes, 15-30 minutes, and 15-20 minutes.

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