Radio frequency resonance electromagnetic wave field solid tumor target heating device and use method thereof

Abstract

The invention belongs to the technical field of medical equipment, and particularly relates to a radio frequency resonance electromagnetic wave field solid tumor target heating device and a use method thereof. The device comprises a radio frequency power supply, a matching network, a Tesla coil, an upper polar plate, a lower polar plate and a water-cooling circulating radiator, the radio frequency power supply is connected to the matching network through the coaxial transmission line, and the matching network can change the impedance characteristic of the transmission line through the adjustable capacitor so as to supply power to the Tesla coil in a matching manner; the primary coil and the secondary coil of the Tesla coil can generate magnetic coupling resonance, and a strong electric field and a strong magnetic field can be generated between the two polar plates. The Tesla coil is used for generating a strong electric field and a strong magnetic field, the nano iron particles in the electric field are easily magnetized and polarized to generate a heating effect, a solution containing the nano iron particles is injected into a solid tumor, then the solid tumor is placed in the two polar plates, tumor cells can be heated, and apoptosis of the tumor cells is promoted.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical equipment, and in particular relates to a radio frequency resonant electromagnetic wave field solid tumor target heating device and a use method thereof. Background Art

[0002] Tesla coil is a transformer that operates on the principle of resonance, and is mainly used to produce high-voltage, high-frequency, and low-current alternating current. Tesla coils are generally composed of a primary resonant coil and a secondary resonant coil. Tesla coils use the principle of resonance to oscillate and boost the voltage with two coils, and can obtain high-frequency and high-voltage alternating current from the discharge terminal. The voltage breaks through the air to form an arc discharge device, that is, a high-voltage generator that uses high-voltage resonance for energy conversion.

[0003] Nano-iron particles have a diameter of 1nm to 100nm and have the characteristics of low toxicity, high stability and super strong magnetic sensitivity. Nano-iron particles have good dielectric properties, can bind to a variety of biomacromolecules, and can heat up rapidly in an alternating magnetic field. Under the state of radio frequency electromagnetic field, nano-iron particles selectively aggregate in tumors, which can enhance the local magnetic field at the tumor and prolong the drug retention time.

[0004] Cancer cells are mutated human cells that are more sensitive to heat than normal cells. At a temperature of 42 degrees, cancer cells will die due to heat. However, normal tissue cells are relatively heat-resistant, and their safe temperature limit is about 45 degrees. Therefore, at such a temperature, we can effectively destroy tumor cells while ensuring that normal tissue cells are not damaged. Currently, the treatment of cancer mainly relies on radiotherapy, chemotherapy, and surgery. However, these traditional methods often have certain side effects on patients during the treatment process, which not only kills cancer cells, but also inevitably harms normal cells, bringing additional physical burden and harm to patients. After searching:

[0005] Shi Shuqin et al. introduced a tumor treatment method in "Experiences in Nursing of Malignant Tumor Patients Using Extracorporeal High Frequency Hyperthermia [J]. Hebei Medicine, 2010, 32(14): 1984." Hyperthermia is gaining more and more attention as a "green therapy" for tumor treatment. The target organ for killing tumor cells by high temperature (42-43°C) is the cell membrane. High temperature causes changes in the fluidity and permeability of the cell membrane, causing changes in the intracellular environment, leading to cell death. However, the heat dose distribution is uneven during hyperthermia, making it difficult to completely kill tumor cells.

[0006] Guo Wenna designed an array antenna with an operating frequency of 2450MHz and a ZrMOF-Cys nanoparticle with good warming effect and low toxicity in "Research on Tumor Microwave Hyperthermia Technology Combining Array Antennas with MOF Materials [D]. Inner Mongolia University of Science and Technology, 2021. DOI: 10.27724 / d.cnki.gnmgk.2020.000576". Experiments have shown that in the electromagnetic field generated by the array antenna with an operating frequency of 2450MHz, ZrMOF-Cys nanoparticles can concentrate energy at the tumor site, achieve the effect of conformal hyperthermia, and have good tumor treatment effects. However, the large-scale heating array antenna designed by it will still cause damage to the surrounding normal tissues during long-term hyperthermia, and the targeting effect of MOF materials is low.

[0007] Gu Hongyuan et al. introduced a method of microwave focusing to treat tumors in "Exploration and Research on Microwave Interference Focusing Using Amplitude Division Method [D]. Northeast Forestry University, 2020. DOI: 10.27009 / d.cnki.gdblu.2020.000840." This method is safe and reliable, can accurately locate the location of the tumor, and is painless and non-invasive. In the process of microwave thermal therapy, the microwave focusing function is used to focus energy on specific parts of the body through a microwave focusing device, which can achieve thermal ablation at specific locations. However, when using the above method to focus, electromagnetic energy loss often occurs during the transmission of microwaves, resulting in the weakening of the field strength after the energy is focused on the corresponding position, and the depth of penetration into the specific part is limited, thereby weakening the effect of microwave thermal therapy.

[0008] Liu Jinmeng designed and developed an ultrasonic focusing system based on phased array technology in "Research and Implementation of Magnetic Resonance-Guided Ultrasonic Focusing System [D]. Wuhan University of Technology, 2021. DOI: 10.27381 / d.cnki.gwlgu.2020.000239". The system uses a transformer impedance matching method with a ferrite magnetic ring as the magnetic core, optimizes the circuit design, and reduces the reflection of the signal during transmission. Experiments show that the focused sound field generated by the ultrasonic focusing system can significantly increase the temperature of the tissue. However, the focus energy of multi-point focusing in space is low, and the temperature measurement error of the magnetic resonance temperature measurement method is large.

[0009] Liu Jinbo et al. introduced the modification of Fe3O4 magnetic nanoparticles and their application in tumor treatment in "Modification of Fe3O4 magnetic nanoparticles and their application in tumor treatment [J]. Applied Chemical Industry: DOI: 10.16581 / j.cnki.issn1671-3206.20240401.016." By modifying the magnetic nanoparticles and combining them with organic polymers or inorganic nanomaterials, they are given functionalization, which significantly increases the biocompatibility and dispersibility of Fe3O4-MNPs. However, the toxicology, in vivo metabolism and side effects of Fe3O4-MNPs have not been completed, and their ecotoxicity effects are often overlooked, which can easily cause harmful toxicity to non-target tissues or organs.

[0010] Chinese patent document with publication number CN208046478U discloses a new type of Tesla coil, whose frequency can be adjusted to achieve a resonant state and output a higher voltage, but it is not suitable for application in the biomedical field.

[0011] A Chinese patent document with publication number CN103184033B discloses a method for preparing a barium ferrite composite material. The prepared barium ferrite composite material has uniform composition and good dielectric properties, but only considers the performance in the high frequency band.

[0012] In summary, traditional thermal therapy, microwave focusing, and ultrasound focusing have defects in the treatment of solid tumors. The electromagnetic waves emitted by the radio frequency power source are usually transmitted in a divergent manner, which has the disadvantage of being difficult to focus locally. Therefore, how to develop a Tesla coil to generate radio frequency electromagnetic waves to irradiate solid tumor target heating devices and treatment methods is a problem that needs to be solved at present. Summary of the invention

[0013] The purpose of the present invention is to overcome the above-mentioned problems existing in the conventional technology and to provide a radio frequency resonant electromagnetic wave field solid tumor target heating device and a method for using the same.

[0014] In order to achieve the above technical objectives and the above technical effects, the present invention is implemented through the following technical solutions:

[0015] The present invention provides a radio frequency resonant electromagnetic wave field solid tumor target heating device, which comprises a radio frequency power supply, a matching network, a Tesla coil, an upper pole plate, a lower pole plate and a water-cooled circulating radiator; the radio frequency power supply is connected to the matching network through a coaxial transmission line, and the matching network can change the impedance characteristics of the transmission line through an adjustable capacitor, so as to match and power the Tesla coil; the Tesla coil, the upper pole plate, the lower pole plate and the water-cooled circulating radiator are installed together inside a container, the primary coil and the secondary coil of the Tesla coil can undergo magnetic coupling resonance, and a strong electric field and a strong magnetic field can be generated between the upper pole plate and the lower pole plate.

[0016] Furthermore, in the above-mentioned radio frequency resonant electromagnetic wave field solid tumor target heating device, the frequency of the radio frequency power supply is set to 13.56MHz, and the maximum output power is 300W.

[0017] Furthermore, in the above-mentioned radio frequency resonant electromagnetic wave field solid tumor target heating device, the matching network is composed of two adjustable capacitors and an inductor coil. Adjusting the capacitance values ​​of the two adjustable capacitors to match the inductor coil can change the impedance characteristics of the transmission line, thereby matching the power supply to the drive coil.

[0018] Furthermore, in the above-mentioned radio frequency resonant electromagnetic wave field solid tumor target heating device, the Tesla coil is composed of a primary coil and a secondary coil, wherein the primary coil is wound with 5 turns of hollow copper wire, and the secondary coil is wound with 64 turns of enameled wire.

[0019] Furthermore, in the above-mentioned radio frequency resonant electromagnetic wave field solid tumor target heating device, the upper electrode plate adopts a planar spiral coil, and the parameters of the planar spiral coil are: wire diameter 1mm, coil inner diameter 5mm, coil outer diameter 35mm, number of turns 6 turns, and turn spacing 5mm.

[0020] Furthermore, in the above-mentioned radio frequency resonant electromagnetic wave field solid tumor target heating device, the lower electrode plate is made of a copper plate with a diameter of 150 mm and a thickness of 0.5 mm.

[0021] Furthermore, in the above-mentioned radio frequency resonant electromagnetic wave field solid tumor target heating device, the device is installed in a normal temperature room.

[0022] The present invention also provides a method for using a radio frequency resonant electromagnetic wave field solid tumor target heating device, comprising the following steps:

[0023] S1. Connect the RF power supply to the matching network through a coaxial transmission line. The matching network changes the impedance characteristics of the transmission line through an adjustable capacitor, thereby matching the power supply to the Tesla coil.

[0024] S2. The primary coil and the secondary coil of the Tesla coil undergo magnetic coupling resonance, generating a strong electric field and a strong magnetic field between the upper plate and the lower plate;

[0025] S3. Nano-iron particles are easily magnetized and polarized in strong electric and magnetic fields to produce a heating effect, thereby achieving the purpose of causing cancer cells to die.

[0026] The beneficial effects of the present invention are:

[0027] In the specific operation of the radio frequency resonant electromagnetic wave field solid tumor target heating device provided by the present invention, the frequency of the radio frequency power supply is set to 13.56MHz, the maximum value of the output power is 300W, and the radio frequency wave is radiated to the Tesla coil through the connection circuit. The Tesla coil is connected to the upper plate and the lower plate, and the middle area of ​​the two plates will induce an alternating strong electric field and a strong magnetic field. In addition, the nano iron particles are non-toxic, and the nano iron particles will be magnetized and polarized in the electromagnetic field, and the magnetization and polarization cause the nano iron particles to heat up. This precise, non-contact spatial positioning heating can effectively kill cancer cells, while reducing damage to normal cells around cancer cells.

[0028] Of course, any product implementing the present invention does not necessarily need to achieve all of the above advantages at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for describing the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative work.

[0030] Figure 1 It is a structural schematic diagram of the device of the present invention;

[0031] Figure 2 It is the circuit diagram of the device and a partial enlarged diagram of the Tesla coil;

[0032] Figure 3 It is the schematic diagram of the experimental simulation;

[0033] In the accompanying drawings, the reference numerals of the various components are as follows:

[0034] 1-RF power supply, 2-matching network, 3-Tesla coil, 4-upper plate, 5-lower plate, 6-water-cooled circulating radiator, 7-mouse with cancer cells in its body. DETAILED DESCRIPTION

[0035] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0036] like Figure 1 and Figure 2As shown, this embodiment provides a radio frequency resonant electromagnetic wave field solid tumor target heating device, which includes a radio frequency power supply 1, a matching network 2, a Tesla coil 3, an upper electrode 4, a lower electrode 5 and a water-cooled circulating radiator 6; the figure simulates the distribution of the electric field and the magnetic field between the two electrodes, and a mouse 7 containing cancer cells in the body is placed between the two electrodes for simulation.

[0037] The RF power supply 1 is connected to the matching network 2 through a coaxial transmission line. The matching network 2 can change the impedance characteristics of the transmission line through an adjustable capacitor, thereby matching the power supply to the Tesla coil 3; the Tesla coil 3, the upper pole plate 4, the lower pole plate 5, and the water-cooled circulating radiator 6 are installed together inside the container. The primary coil and the secondary coil of the Tesla coil 3 can undergo magnetic coupling resonance, and a strong electric field and a strong magnetic field can be generated between the upper pole plate 4 and the lower pole plate 5, which can magnetize and polarize the metal iron particles, causing the cancer cells to heat up and die.

[0038] In this embodiment, the frequency of the radio frequency power source 1 is set to 13.56 MHz, and the maximum output power is 300 W.

[0039] In this embodiment, the matching network 2 is composed of two adjustable capacitors and an inductor. By adjusting the capacitance values ​​of the two adjustable capacitors to match the inductor, the impedance characteristics of the transmission line can be changed, thereby matching the power supply to the drive coil.

[0040] In this embodiment, the Tesla coil 3 is composed of a primary coil and a secondary coil, wherein the primary coil is wound by 5 turns of hollow copper wire, and the secondary coil is wound by 64 turns of enameled wire.

[0041] In this embodiment, the upper electrode plate 4 adopts a planar spiral coil, and the parameters of the planar spiral coil are: wire diameter 1mm, coil inner diameter 5mm, coil outer diameter 35mm, number of turns 6 turns, and turn spacing 5mm.

[0042] In this embodiment, the lower electrode plate 5 is made of a copper plate with a diameter of 150 mm and a thickness of 0.5 mm.

[0043] In this embodiment, the primary coil and the secondary coil of the Tesla coil 3 have self-inductance, and there is mutual inductance between the coils. When the frequency is set to 13.56MHz, the hollow copper wire and the enameled wire can be equivalent to the coil inductance, thereby forming a resonant circuit. When the device is at an operating frequency of 13.56MHz, the electric field and magnetic field generated by the Tesla coil 3 have the best magnetization and polarization effect on the nano-iron material.

[0044] In this embodiment, the copper material used for the primary coil of the Tesla coil 3 has excellent conductivity, the copper coil has good flexibility, is easy to bend, is safe, stable and reliable, and has higher transmission efficiency. The water-cooled circulating radiator 6 can keep the coil temperature at a lower level, which greatly alleviates the problem of the coil being unable to work for a long time due to heating.

[0045] This embodiment also provides a method for using a radio frequency resonant electromagnetic wave field solid tumor target heating device, comprising the following steps:

[0046] S1. The device is installed in a room temperature, and the RF power source 1 is connected to the matching network 2 through a coaxial transmission line. The matching network 2 changes the impedance characteristics of the transmission line through an adjustable capacitor, thereby matching the power supply to the Tesla coil 3;

[0047] S2, the primary coil and the secondary coil of the Tesla coil 3 are magnetically coupled and resonated, and a strong electric field and a strong magnetic field are generated between the upper plate 4 and the lower plate 5; a mouse 7 containing cancer cells is placed on the lower plate 5, and a water-cooled circulating radiator 6 is started to dissipate heat and cool the container;

[0048] S3. The nano-iron particles placed in the two polar plates are easily magnetized and polarized to produce enhanced heating. Injecting a solution containing nano-iron particles into a solid tumor and then placing it on the lower polar plate can target and heat apoptotic tumor cells.

[0049] The preferred embodiments of the present invention disclosed above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to specific implementation methods. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. Radio frequency resonant electromagnetic wave field solid tumor target heating device, characterized in that: The device comprises a radio frequency power source (1), a matching network (2), a Tesla coil (3), an upper pole plate (4), a lower pole plate (5) and a water-cooled circulating radiator (6); the radio frequency power source (1) is connected to the matching network (2) via a coaxial transmission line, and the matching network (2) can change the impedance characteristics of the transmission line through an adjustable capacitor, thereby matching and supplying power to the Tesla coil (3); the Tesla coil (3), the upper pole plate (4), the lower pole plate (5) and the water-cooled circulating radiator (6) are installed together inside a container, and the primary coil and the secondary coil of the Tesla coil (3) can undergo magnetic coupling resonance, and a strong electric field and a strong magnetic field can be generated between the upper pole plate (4) and the lower pole plate (5).

2. The radio frequency resonant electromagnetic wave field solid tumor target heating device according to claim 1, characterized in that: The frequency of the radio frequency power source (1) is set to 13.56 MHz, and the maximum output power is 300 W.

3. The radio frequency resonant electromagnetic wave field solid tumor target heating device according to claim 1, characterized in that: The matching network (2) is composed of two adjustable capacitors and an inductor coil. By adjusting the capacitance values ​​of the two adjustable capacitors to match the inductor coil, the impedance characteristics of the transmission line can be changed, thereby matching the power supply to the drive coil.

4. The radio frequency resonant electromagnetic wave field solid tumor target heating device according to claim 1, characterized in that: The Tesla coil (3) is composed of a primary coil and a secondary coil, wherein the primary coil is wound with 5 turns of hollow copper wire, and the secondary coil is wound with 64 turns of enameled wire.

5. The radio frequency resonant electromagnetic wave field solid tumor target heating device according to claim 1, characterized in that: The upper electrode plate (4) adopts a planar spiral coil, and the parameters of the planar spiral coil are: wire diameter 1mm, coil inner diameter 5mm, coil outer diameter 35mm, number of turns 6 turns, and turn spacing 5mm.

6. The radio frequency resonant electromagnetic wave field solid tumor target heating device according to claim 1, characterized in that: The lower electrode plate (5) is made of a copper plate with a diameter of 150 mm and a thickness of 0.5 mm.

7. The radio frequency resonant electromagnetic wave field solid tumor target heating device according to claim 1, characterized in that: The device is installed in a normal temperature room.

8. The method for using the radio frequency resonant electromagnetic wave field solid tumor target heating device according to any one of claims 1 to 7, characterized in that: The following steps are involved: S1, connecting a radio frequency power source (1) to a matching network (2) via a coaxial transmission line, wherein the matching network (2) changes the impedance characteristics of the transmission line via an adjustable capacitor, thereby matching the power supply to the Tesla coil (3); S2, the primary coil and the secondary coil of the Tesla coil (3) are magnetically coupled and resonant, generating a strong electric field and a strong magnetic field between the upper plate (4) and the lower plate (5); S3. Nano-iron particles are easily magnetized and polarized in strong electric and magnetic fields to produce a heating effect, thereby achieving the purpose of causing cancer cells to die.

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