Cross moxibustion prescription for treating heart-spleen deficiency type insomnia in combination with relaxation training

Abstract

The invention relates to the field of cross moxibustion prescriptions, in particular to a cross moxibustion prescription for treating heart-spleen deficiency type insomnia by combining relaxation training, which comprises the following Chinese herbal medicines: 12-15g of bighead atractylodes rhizome, 12-15g of poria with hostwood, 15-18g of astragalus membranaceus, 10-13g of fried spina date seed, 10-13g of ginseng, 6-9g of elecampane, 6-9g of honey-fried licorice root, 12-15g of angelica sinensis, 10-13g of polygala tenuifolia and 2-5g of borneol. The traditional Chinese medicine prescription spleen-invigorating decoction for treating insomnia due to heart-spleen deficiency mainly has the effects of replenishing qi and enriching blood, tonifying spleen and nourishing heart, and soothing nerves and sedating mind, and for patients suffering from insomnia and heart-spleen deficiency, various acupoints are combined in the range of a cross moxibustion method, so that the balance of yin and yang of human bodies can be adjusted, and the effects of tonifying spleen and nourishing heart and soothing nerves are achieved; the state of yin-yang imbalance of the insomnia patient can be effectively improved, and the anxiety of the insomnia patient can be relieved through auxiliary relaxation training such as muscle relaxation training, deep breath relaxation training and meditation relaxation training.

Description

Technical Field

[0001] The invention relates to the field of cross-moxibustion prescriptions, and in particular to a cross-moxibustion prescription for treating insomnia of heart and spleen deficiency type combined with relaxation training. Background Art

[0002] Insomnia is a type of sleep disorder characterized by difficulty falling asleep, difficulty maintaining sleep, early awakening, decreased sleep quality and reduced sleep time, accompanied by daytime functional activity disorders. Epidemiological studies have shown that the incidence of insomnia in adults in my country is as high as 38.2%, which means that there are nearly 300 million people with sleep disorders in my country. The age of insomnia sufferers is getting younger and younger, and the incidence is increasing year by year.

[0003] At present, the treatment of sleep disorders mainly adopts comprehensive treatment methods, including drug therapy and non-drug therapy. Drug therapy currently mainly includes four categories: benzodiazepines, melatonin receptor agonists, histamine receptor antagonists and orexin receptor antagonists. However, long-term drug treatment will cause adverse reactions such as drug dependence and tolerance. Long-term lack of sleep can easily lead to reduced daily work ability and judgment, memory loss, inability to concentrate, decreased immunity, endocrine and neurological dysfunction, and can also induce or even aggravate various existing cardiovascular and cerebrovascular diseases, diabetes, and a series of mental disorders. For patients with long-term insomnia, taking a large amount of sedatives and hypnotic drugs can also cause drug or alcohol dependence and abuse. Sleep disorders not only reduce the quality of life of patients, but also increase the occurrence of traffic accidents and consume a large amount of social public health resources. Therefore, it is of great significance to explore methods with significant clinical efficacy in the treatment of insomnia.

[0004] Therefore, in order to address the above-mentioned problem of long-term use of sedative hypnotic drugs, which will cause dependence and cause great harm to the body, a cross-moxibustion prescription combined with relaxation training can be designed to treat insomnia of the heart and spleen deficiency type. Summary of the invention

[0005] In order to overcome the problem of long-term use of sedatives and hypnotic drugs, which will cause dependence and great harm to the body.

[0006] The technical scheme of the present invention is: a cross-moxibustion prescription for treating insomnia of deficiency of both heart and spleen type combined with relaxation training, comprising the following Chinese herbal medicine formula: 12g-15g of Atractylodes macrocephala, 12g-15g of Poria, 15g-18g of Astragalus, 10g-13g of stir-fried Ziziphus jujuba seeds, 10g-13g of Ginseng, 6g-9g of Aucklandia root, 6g-9g of roasted Licorice root, 12g-15g of Angelica sinensis, 10g-13g of Polygala tenuifolia and 2g-5g of Borneol.

[0007] As a preferred method, the steps of the prescription preparation method are as follows:

[0008] Step 1: Accurately weigh Atractylodes macrocephala, Poria, Astragalus, stir-fried Ziziphus jujuba seeds, Ginseng, Aucklandia lappa, roasted Licorice root, Angelica sinensis, Polygala tenuifolia, and Borneol according to the prescription;

[0009] Step 2: Pour the medicinal materials weighed in step 1 into the superfine pulverizer, grind and mix them in the superfine pulverizer, turn off the machine, and collect the Chinese medicinal powder in the collection box;

[0010] Step 3: Pour the collected Chinese medicine powder into the sieve, gently shake the sieve, and collect the fine Chinese medicine powder;

[0011] Step 4: Seal and store in a black light-proof sealed bottle in a dry, well-ventilated environment for later use. Label the name of the Chinese medicine, crushing date, and storage conditions on the black sealed bottle.

[0012] Preferably, the sieve in step 2 is a 100-mesh sieve.

[0013] As a preferred method, the treatment method comprises the following steps:

[0014] Step 1: Cover the moxibustion site with protective gauze, and then place the cross moxibustion tool;

[0015] Step 2: Evenly put the prepared powder into the special moxibustion tool for cross moxibustion. The cross moxibustion is centered on the navel and horizontally covers the area of ​​the line connecting the two sides of the Daheng acupoints, covering the Langshu, Tianshu, and Daheng acupoints;

[0016] Step 3: Light the powder in the moxibustion tool and let it burn naturally; moxibustion in a cross range can effectively regulate the rise and fall of human qi and the balance of yin and yang, and coordinate with the Shenque point and the Ren meridian points in the abdomen to act on the body to achieve the effect of strengthening the spleen, nourishing the heart and calming the mind. The vertical direction is the area connecting the Zhongwan point to the Zhongji point, covering the Zhongwan, Xiawan, Qihai, Guanyuan and Zhongji points.

[0017] Preferably, the patient is treated by lying flat on the treatment bed with the abdomen facing upward.

[0018] Preferably, the relaxation training adopts one or a combination of progressive muscle relaxation training, deep breathing relaxation training, and meditation relaxation training.

[0019] Beneficial effects of the present invention:

[0020] The prescription of the present invention is made into Chinese medicine powder by combining Atractylodes macrocephala, Poria, Astragalus, stir-fried Ziziphus jujuba seeds, ginseng, costusroot, roasted liquorice, angelica, Polygala tenuifolia and borneol, and is modified based on Guipi decoction, a classic prescription for treating insomnia caused by deficiency of both heart and spleen in traditional Chinese medicine. It has the effects of replenishing qi and blood, strengthening spleen and nourishing heart, and calming nerves and stabilizing mind, and is targeted at patients with insomnia caused by deficiency of both heart and spleen.

[0021] The cross moxibustion method is used for treatment. The combined use of various acupoints in the range of cross moxibustion can adjust the balance of yin and yang in the human body, strengthen the spleen, nourish the heart and calm the mind, and can effectively improve the imbalance of yin and yang in insomnia patients.

[0022] Combined with auxiliary relaxation training such as muscle relaxation training, deep breathing relaxation training, meditation relaxation training, etc., the anxiety of insomnia patients can be relieved;

[0023] When the cross-moxibustion prescription combined with relaxation training for treating insomnia of deficiency of both heart and spleen is used to treat patients, patients have good comfort and are easy to accept. Some patients have a desire to fall asleep and can even fall into a deep sleep during the treatment. DETAILED DESCRIPTION

[0024] The present invention will be further described below in conjunction with the embodiments.

[0025] Example 1

[0026] The present invention provides an embodiment: a cross-moxibustion prescription for treating insomnia of deficiency of both heart and spleen type combined with relaxation training, comprising the following Chinese herbal medicine formula: 12g of Atractylodes macrocephala, 12g of Poria, 15g of Astragalus, 10g of stir-fried Ziziphus jujuba seeds, 10g of ginseng, 6g of costusroot, 6g of roasted liquorice, 12g of Angelica sinensis, 10g of Polygala tenuifolia, and 2g of borneol.

[0027] As a preferred method, the steps of the prescription preparation method are as follows:

[0028] Step 1: Accurately weigh Atractylodes macrocephala, Poria, Astragalus, stir-fried Ziziphus jujuba seeds, Ginseng, Aucklandia lappa, roasted Licorice root, Angelica sinensis, Polygala tenuifolia, and Borneol according to the prescription;

[0029] Step 2: Pour the medicinal materials weighed in step 1 into the superfine pulverizer, grind and mix them in the superfine pulverizer, turn off the machine, and collect the Chinese medicinal powder in the collection box;

[0030] Step 3: Pour the collected Chinese medicine powder into the sieve, gently shake the sieve, and collect the fine Chinese medicine powder;

[0031] Step 4: Seal and store in a black light-proof sealed bottle in a dry, well-ventilated environment for later use. Label the name of the Chinese medicine, crushing date, and storage conditions on the black sealed bottle.

[0032] Preferably, the sieve in step 2 is a 100-mesh sieve.

[0033] As a preferred method, the treatment method comprises the following steps:

[0034] Step 1: Cover the moxibustion site with protective gauze, and then place the cross moxibustion tool;

[0035] Step 2: Evenly put the prepared powder into the special moxibustion tool for cross moxibustion. The cross moxibustion is centered on the navel and horizontally covers the area of ​​the line connecting the two sides of the Daheng acupoints, covering the Langshu, Tianshu, and Daheng acupoints;

[0036] Step 3: Light the powder in the moxibustion tool and let it burn naturally; moxibustion in a cross range can effectively regulate the rise and fall of human qi and the balance of yin and yang, and coordinate with the Shenque point and the Ren meridian points in the abdomen to act on the body to achieve the effect of strengthening the spleen, nourishing the heart and calming the mind. The vertical direction is the area connecting the Zhongwan point to the Zhongji point, covering the Zhongwan, Xiawan, Qihai, Guanyuan and Zhongji points.

[0037] Preferably, the patient is treated by lying flat on the treatment bed with the abdomen facing upward.

[0038] Preferably, the relaxation training adopts progressive muscle relaxation training.

[0039] Example 2

[0040] The cross-moxibustion prescription combined with relaxation training for the treatment of insomnia of deficiency of both heart and spleen includes the following Chinese herbal medicine formula: Atractylodes macrocephala 13g, Poria 14g, Astragalus 17g, stir-fried Ziziphus jujuba seeds 10g, Ginseng 12g, Aucklandia lappa 7g, roasted Licorice root 8g, Angelica 13g, Polygala tenuifolia 11g, and Borneol 3g.

[0041] As a preferred method, the steps of the prescription preparation method are as follows:

[0042] Step 1: Accurately weigh Atractylodes macrocephala, Poria, Astragalus, stir-fried Ziziphus jujuba seeds, Ginseng, Aucklandia lappa, roasted Licorice root, Angelica sinensis, Polygala tenuifolia, and Borneol according to the prescription;

[0043] Step 2: Pour the medicinal materials weighed in step 1 into the superfine pulverizer, grind and mix them in the superfine pulverizer, turn off the machine, and collect the Chinese medicinal powder in the collection box;

[0044] Step 3: Pour the collected Chinese medicine powder into the sieve, gently shake the sieve, and collect the fine Chinese medicine powder;

[0045] Step 4: Seal and store in a black light-proof sealed bottle in a dry, well-ventilated environment for later use. Label the name of the Chinese medicine, crushing date, and storage conditions on the black sealed bottle.

[0046] Preferably, the sieve in step 2 is a 100-mesh sieve.

[0047] As a preferred method, the treatment method comprises the following steps:

[0048] Step 1: Cover the moxibustion site with protective gauze, and then place the cross moxibustion tool;

[0049] Step 2: Evenly put the prepared powder into the special moxibustion tool for cross moxibustion. The cross moxibustion is centered on the navel and horizontally covers the area of ​​the line connecting the two sides of the Daheng acupoints, covering the Langshu, Tianshu, and Daheng acupoints;

[0050] Step 3: Light the powder in the moxibustion tool and let it burn naturally; moxibustion in a cross range can effectively regulate the rise and fall of human qi and the balance of yin and yang, and coordinate with the Shenque point and the Ren meridian points in the abdomen to act on the body to achieve the effect of strengthening the spleen, nourishing the heart and calming the mind. The vertical direction is the area connecting the Zhongwan point to the Zhongji point, covering the Zhongwan, Xiawan, Qihai, Guanyuan and Zhongji points.

[0051] Preferably, the patient is treated by lying flat on the treatment bed with the abdomen facing upward.

[0052] Preferably, the relaxation training adopts several combinations of deep breathing relaxation training and meditation relaxation training.

[0053] Explanation of the cross-moxibustion prescription combined with relaxation training for the treatment of insomnia of heart and spleen deficiency type:

[0054] The astragalus in the prescription is slightly warm in nature, sweet in taste, and enters the spleen and lung meridians. It is good at entering the spleen and stomach. It can not only tonify the middle and replenish qi, and treat spleen deficiency, but also raise yang and lift the sunken, and treat spleen deficiency and qi sinking. "Medical Records of Chinese and Western Medicine" records its efficacy as: "It can tonify qi, and raise qi, and is good at treating the sinking of the great qi (i.e., zongqi) in the chest." Pharmacological studies have shown that astragalus has multiple effects such as neuroprotection, promoting metabolism, immune regulation, enhancing myocardial contractility, and anti-fatigue. Astragalus total flavonoids can increase the expression of p-PI3K and p-AKT proteins in the brain tissue of rats with cerebral ischemia-reperfusion injury, activate the PI3K / AKT signaling pathway, and play a protective role against cerebral ischemia-reperfusion injury.

[0055] Atractylodes macrocephala is warm in nature, bitter and sweet in taste, and enters the spleen and stomach meridians. It has the functions of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis. "Shennong's Herbal Classic" records its functions: "It can treat wind-cold-dampness arthralgia, dead muscles, spasms, jaundice, stop sweating, and eliminate heat and digestion." Modern pharmacological studies have shown that atractylodes lactone III, the main component of Atractylodes macrocephala, can improve neurological deficits in rats with ischemic stroke, and its mechanism of action is related to the activation of the Shh / Ptch1 signaling pathway. Atractylodes macrocephala polysaccharides show potential therapeutic effects against depressive-like behaviors by regulating the multi-target effects of the brain-gut axis and the HPA axis.

[0056] Poria is mild in nature, sweet and light in taste, and has the function of calming the mind and soothing the nerves. The Materia Medica says that it "treats epilepsy, calms the nerves and stabilizes the mind, and replenishes fatigue." Pharmacological studies have shown that the decoction of Poria and Poria can significantly increase the sleep rate of animals given a subthreshold dose of sodium pentobarbital, indicating that the decoction has a certain anticonvulsant effect, and the decoction of Poria is stronger than that of Poria. The pachymannan, pachymic acid, dehydropachymic acid, etc. in Poria can promote the biosynthesis of IgA, IgG and IgM or inhibit the secretion of IL-2 and IFN-γ to play an immunoregulatory role.

[0057] Angelica sinensis is warm in nature, sweet and pungent in taste, and enters the heart, spleen, and liver meridians. It is sweet, warm, and moist in nature, and its pungent properties can warm and promote blood circulation. It can both tonify blood and promote blood circulation and remove blood stasis. "Medical Origins" states: "Angelica sinensis has a warm nature and a sweet taste. It can harmonize blood and tonify blood, its tail can break up blood, and its body can harmonize blood." Pharmacological studies have shown that Angelica sinensis has sedative, hypnotic, blood-tonifying and immune-promoting effects. MC-S in Angelica sinensis extract can prolong the sleep time induced by sodium pentobarbital, and APS can regulate nonspecific immunity and specific immunity. Angelica sinensis water extract has a significant promoting effect on the production of red blood cells and hemoglobin in mice.

[0058] Fried Chinese jujube seeds are mild in nature, sweet and sour in taste, and enter the liver, gallbladder, and heart meridians. They can nourish the heart and liver, calm the mind and soothe the nerves, and reduce sweat and produce body fluid. "Famous Doctors' Records" says: "It can treat insomnia, pain above and below the navel, long-term diarrhea, sweating and thirst, tonify the middle, benefit the liver qi, strengthen the muscles and bones, help the yin qi, and make people fat and healthy." Modern pharmacological studies have shown that Chinese jujube seed saponins have significant sedative and hypnotic effects. They can increase the expression of γ-aminobutyric acid receptors in hippocampal neurons, and at the same time significantly enhance the opening frequency of chloride ion channels, thereby showing obvious sedative and hypnotic effects.

[0059] Ginseng is slightly warm in nature, sweet and slightly bitter in taste, and enters the lung, heart, and spleen meridians. It is an important medicine for nourishing the heart and spleen. It can improve symptoms of heart and spleen deficiency such as fatigue, palpitations, chest tightness and shortness of breath, and can calm the mind and improve intelligence, treat insomnia, nightmares, and forgetfulness. "Bencao Huiyan" calls it "a medicine for replenishing qi and blood, assisting essence and nourishing the spirit." Pharmacological studies have shown that ginseng can promote hematopoiesis, regulate the excitation and inhibition of the central nervous system, enhance the flexibility of nerve activity processes, and can increase the activity of pepsin and improve symptoms of spleen deficiency.

[0060] Polygala is warm in nature, bitter and pungent in taste, and enters the heart, lung, and kidney meridians. It is good at dispersing and unblocking, can dispel phlegm and open the orifices, dissipate stagnation, and can open the heart qi and promote kidney qi. It is good at calming the mind, strengthening intelligence and consciousness. "Pharmaceutical Chemistry" says: "Polygala is pungent and strong in taste. It enters the heart and opens the orifices. It is a dispersing medicine. It can treat phlegm and saliva in the heart, blocking the orifices of the heart, causing heat in the heart qi, causing coma, mental stupor, slurred speech, restless sleep, trance, fear, forgetfulness, nightmares, and children's obstruction. It can be temporarily used to dispel phlegm and open the orifices to open the heart qi, so that the coma will naturally calm down." Pharmacological studies have shown that Polygala has sedative, hypnotic, anticonvulsant, and expectorant effects. The ethyl acetate extract of Polygala has a strong central nervous system inhibitory effect, which can increase the sleep rate of mice at a subthreshold hypnotic dose of sodium pentobarbital and prolong the sleep time of a hypnotic dose.

[0061] Costus root is warm in nature, pungent and bitter in taste, and enters the spleen, stomach, large intestine, triple burner, and gallbladder meridians. It has the effects of promoting qi and relieving pain, strengthening the spleen and digesting food. "Bencao Gangmu" says: "It can treat all kinds of qi in the heart and abdomen, stop diarrhea, cholera, dysentery, calm the fetus, strengthen the spleen and digest food, treat emaciation, cold bladder pain, vomiting and regurgitation." Pharmacological studies have shown that costus root extract can enhance the resistance of HepG2 cells to hydrogen peroxide-induced oxidative damage, and its mechanism may involve regulating Nrf2 / HO-1 expression. In addition, costus root extract also has a free radical scavenging ability comparable to vitamin E, has an inhibitory effect on low-density lipoprotein, and can effectively prevent the occurrence of tissue lipid peroxidation damage, and can protect DNA from oxidative damage.

[0062] Roasted licorice root is mild in nature, sweet in taste, and enters the heart, lung, spleen, and stomach meridians. It has the functions of tonifying the spleen and stomach, replenishing qi and restoring the pulse. Licorice glycoside and total flavonoids of licorice are the main basic substances for licorice to exert its antidepressant effect. Studies have shown that licorice glycoside can increase the autonomous exploration activity of depression rat models, improve mental state and relieve anxiety. Licorice can effectively reduce the level of proinflammatory cytokines in lipopolysaccharide-induced mouse depression model, reduce the expression of NF-κB / p-p65 and p-IκBα, and increase the content of hippocampal brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB).

[0063] Borneol is slightly cold in nature and pungent and bitter in taste. It enters the heart, lung, and spleen meridians. The pungent fragrance of borneol can move freely, open all the orifices, and lead the medicine directly to the site of the disease. "Yi Lin Zuan Yao" says that it "has a wandering nature and can also regenerate tissue and relieve pain." Pharmacological studies have shown that the active ingredients of borneol, borneol and isoborneol, have a sedative effect, and borneol can be quickly absorbed through the mesentery and widely distributed in the blood, lungs, spleen, liver, kidneys, myocardium, and skeletal muscle. It also passes through the blood-brain barrier and accumulates in the brain at high levels for a long time.

Claims

1. A cross-moxibustion prescription for treating insomnia of heart and spleen deficiency type combined with relaxation training, characterized in that: The Chinese herbal medicine formula includes: Atractylodes macrocephala 12g-15g, Poria cocos 12g-15g, Astragalus membranaceus 15g-18g, stir-fried Ziziphus jujuba seeds 10g-13g, ginseng 10g-13g, costusroot 6g-9g, roasted liquorice 6g-9g, Angelica sinensis 12g-15g, Polygala tenuifolia 10g-13g, and borneol 2g-5g.

2. The cross-moxibustion prescription for treating insomnia of heart and spleen deficiency type combined with relaxation training according to claim 1, characterized in that: The steps of making the prescription are as follows: Step 1: Accurately weigh Atractylodes macrocephala, Poria, Astragalus, stir-fried Ziziphus jujuba seeds, Ginseng, Aucklandia lappa, roasted Licorice root, Angelica sinensis, Polygala tenuifolia, and Borneol according to the prescription; Step 2: Pour the medicinal materials weighed in step 1 into the superfine pulverizer, grind and mix them in the superfine pulverizer, turn off the machine, and collect the Chinese medicinal powder in the collection box; Step 3: Pour the collected Chinese medicine powder into the sieve, gently shake the sieve, and collect the fine Chinese medicine powder; Step 4: Seal and store in a black light-proof sealed bottle in a dry, well-ventilated environment for later use. Label the name of the Chinese medicine, crushing date, and storage conditions on the black sealed bottle.

3. The cross-moxibustion prescription for treating insomnia of deficiency of both heart and spleen combined with relaxation training according to claim 2, characterized in that: In step 2, the sieve is a 100-mesh sieve.

4. The cross-moxibustion prescription for treating insomnia of heart and spleen deficiency type combined with relaxation training according to claim 1, characterized in that: The treatment method is as follows: Step 1: Cover the moxibustion site with protective gauze, and then place the cross moxibustion tool; Step 2: Evenly put the prepared powder into the special moxibustion tool for cross moxibustion. The cross moxibustion is centered on the navel and horizontally covers the area of ​​the line connecting the two sides of the Daheng acupoints, covering the Langshu, Tianshu, and Daheng acupoints; Step 3: Light the powder in the moxibustion tool and let it burn naturally; moxibustion in a cross range can effectively regulate the rise and fall of human qi and the balance of yin and yang, and coordinate with the Shenque point and the Ren meridian points in the abdomen to act on the body to achieve the effect of strengthening the spleen, nourishing the heart and calming the mind. The vertical direction is the area connecting the Zhongwan point to the Zhongji point, covering the Zhongwan, Xiawan, Qihai, Guanyuan and Zhongji points.

5. The cross-moxibustion prescription for treating insomnia of heart and spleen deficiency type combined with relaxation training according to claim 4, characterized in that: The patient's treatment posture is lying flat on the treatment bed with the abdomen facing upwards.

6. The cross-moxibustion prescription for treating insomnia of heart and spleen deficiency type combined with relaxation training according to claim 1, characterized in that: Auxiliary relaxation training uses one or a combination of progressive muscle relaxation training, deep breathing relaxation training, and meditation relaxation training.