Traditional Chinese medicine composition for treating lumbago caused by blood stasis and dampness obstruction and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for treating blood stasis and dampness stagnation type lumbago and application. The invention belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition comprises the following components: caulis spatholobi, scutellaria baicalensis, rhizoma alismatis, wine-processed angelica sinensis, ligusticum wallichii, poria cocos, raw rhizoma atractylodis macrocephalae, cassia twig, pseudo-ginseng, erythrina bark, salted eucommia ulmoides and radix clematidis. The granules are low in toxic and side effects, small in dependence and good in prognosis; the granules are low in price, efficient in preparation, convenient to carry and take, easy to popularize and good in taste; according to the invention, accurate and efficient treatment is carried out on the most common lumbago syndrome clinically at present.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and specifically refers to a traditional Chinese medicine composition for treating blood stasis and dampness resistance type low back pain and its application. Background Art

[0002] Lumbar disc herniation is a syndrome characterized by degenerative changes in the lumbar disc, rupture of the annulus fibrosus, protrusion of the nucleus pulposus, stimulation or compression of the vertebral nerves and nerve roots, resulting in nerve edema and local inflammatory reactions, which in turn cause severe pain, numbness and even weakness in the waist and lower limbs. Its high incidence, high cost and easy loss of work ability have brought heavy burdens to individuals and society. Lumbar disc herniation is classified as "low back pain" and "arthralgia" in traditional Chinese medicine.

[0003] According to the 2019 Global Burden of Disease Study, low back pain has risen from 13th in 1990 to 9th among the major diseases that cause disability-adjusted life years for all age groups. Among them, lumbar disc herniation is the main and most common cause of low back pain, with an incidence rate of about 2%-3% in the general population and about 4.8% in men over 35 years old. With the changes in modern production and lifestyle, the prevalence of this disease has increased year by year, and it is showing a trend of younger people.

[0004] Research suggests that mechanical compression theory, inflammatory chemical stimulation and autoimmune theory are the main mechanisms of pain caused by lumbar disc herniation. At present, clinical Western medicine treatment is mainly divided into surgical treatment and non-surgical treatment. The risk and economic burden of surgical treatment are relatively large. 80% to 90% of patients can be controlled through conservative treatment, and only 10% to 20% of patients require surgical treatment. Non-surgical treatment is mainly anti-inflammatory and dehydration, mainly including oral non-steroidal anti-inflammatory drugs, opioids, local blockade, epidural injection, etc., but long-term use of antipyretic analgesics can easily cause adverse reactions in the digestive tract and cause ulcer bleeding. Dehydration agents may cause adverse reactions such as hypotension or electrolyte disorders in patients, and cause severe damage to liver and kidney function. The therapeutic effect is difficult to sustain and it is very easy to relapse.

[0005] In recent years, traditional Chinese medicine has shown unique advantages in the treatment of lumbar disc herniation and low back pain. It has the advantages of multi-target overall regulation, significant and lasting efficacy, and few side effects, and has been recognized by more and more patients. Modern Chinese medicine scholars have summarized the syndrome differentiation of low back pain into qi stagnation and blood stasis syndrome, liver and kidney deficiency syndrome, cold dampness and arthralgia syndrome, and damp-heat arthralgia syndrome. According to the syndrome differentiation, the methods are to promote blood circulation and qi, nourish the liver and kidney, strengthen tendons and bones, dispel cold and dampness, dredge collaterals and relieve pain, clear dampness and heat, and promote blood circulation and relieve pain. However, with the change of climate and people's material living conditions, the increase of rainfall, overeating of fat, sweet and greasy food and other factors, the population is more common in phlegm and dampness constitution, especially middle-aged men. Such patients are clinically manifested as low back and leg pain like acupuncture, local refusal to press, inconvenience in bending and stretching, accompanied by soreness and heaviness in the lower back and lower limbs, sticky stool, dark tongue, enlarged tongue, greasy tongue coating, and astringent pulse, showing the syndrome of blood stasis and dampness. There are many kinds of Chinese patent medicines for treating low back pain sold in the market today, and the dosage forms mainly include external plasters, oral capsules, pills or tablets, etc. The main syndromes are mainly blood stasis, kidney deficiency, and cold and dampness, and the methods are to promote blood circulation and remove blood stasis, promote qi and relieve pain, nourish the liver and kidney, strengthen tendons and bones, and dispel cold and dampness and relieve pain. They are widely used and have certain curative effects.

[0006] The commercially available Chinese patent medicines for external use have rich medicinal flavors and a wide range of functions and indications, covering a variety of orthopedic diseases such as acute and chronic injuries, soft tissue lesions, and bone structure lesions. For example, Qizheng Xiaotong Paste, as a kind of external-use patch, is a Tibetan medicine prescription and a national secret prescription. It is composed of medicinal flavors such as single herb and turmeric, and has the effects of promoting blood circulation and removing blood stasis, reducing swelling and relieving pain. It is mainly used for the treatment of acute and chronic musculoskeletal pain such as sprains and contusions, bruises and pain, bone hyperplasia, rheumatism and rheumatoid pain, stiff neck, periarthritis of the shoulder, lumbar muscle strain, and old injuries. It is widely used in clinical practice. However, the pain area of ​​patients in the acute stage of LDH is wide, and discomfort can occur from the waist to the lower limbs. It is difficult for general plasters to cover such a wide area; and some patients are allergic to plasters and still need oral medication as a supplement.

[0007] Oral Chinese patent medicines such as Yaobitong Capsules, Shujinjianyao Pills, Danlutongdu Tablets, Yaotongning Capsules, etc. are all representative Chinese patent medicines commonly used in clinical practice. Yaobitong Capsules have the effects of promoting blood circulation and removing blood stasis, dispelling wind and dampness, promoting qi and relieving pain, and have a relatively satisfactory effect on blood stasis type low back pain. Shujinjianyao Pills have the effects of nourishing the liver and kidneys, strengthening muscles and bones, dispelling wind and dampness, activating collaterals and relieving pain, and are mostly used for kidney deficiency type low back and knee pain. Clinical observations of this medicine and centralized monitoring in hospitals show that Shujinjianyao Pills can improve the clinical symptoms of low back pain and lower limb pain caused by kidney deficiency type LDH. Danlutongdu Tablets have the effects of promoting blood circulation and unblocking the Du channel, benefiting the kidney and unblocking the collaterals, and are used for LDH and lumbar spinal stenosis, which are symptoms of kidney deficiency and blood stasis blocking the Du channel. Clinical observations show that Danlutongdu Tablets can improve pain and functional disorders in patients with LDH kidney deficiency and blood stasis, and reduce the recurrence rate. Yaotongning Capsule is used for patients with lumbago due to cold-dampness syndrome. It has the effects of reducing swelling and relieving pain, dispersing cold pathogens, warming the meridians and unblocking collaterals. Clinical studies have found that it has a considerable effect on lumbago due to cold-dampness and arthralgia. However, the above-mentioned Chinese patent medicines lack the emphasis on blood stasis and dampness syndrome, and only treat from the perspective of cold-dampness or blood stasis, which is not very targeted for patients with lumbago due to blood stasis and dampness syndrome.

[0008] This study proposes to develop Fujisawa Jianyao Granules, which are targeted at patients with low back pain caused by blood stasis and dampness. The method is to promote blood circulation, eliminate dampness, dredge meridians and relieve pain, dredge blocked meridians, and penetrate and benefit the internal organs trapped by dampness, thus filling the gap in the Chinese patent medicine market for the treatment of low back pain caused by blood stasis and dampness. Summary of the invention

[0009] The purpose of the present invention is to provide a Chinese medicine composition for treating blood stasis and dampness obstruction type low back pain and its application. The present invention can reduce the cost of treating low back pain caused by lumbar disc herniation, alleviate its toxic and side effects, reduce dependence, and improve prognosis; at the same time, through a Chinese medicine composition that is low in price, efficient in preparation, and convenient to carry and take, the time and space restrictions on the treatment of patients with low back pain caused by lumbar disc herniation are reduced; the present invention is aimed at the most common type of low back pain syndrome in clinical practice and provides efficient treatment.

[0010] In order to achieve the above-mentioned purpose, the technical scheme adopted by the present invention is as follows: a Chinese medicine composition and application for treating low back pain caused by blood stasis and dampness obstruction, the Chinese medicine composition comprising the following components: Millettia reticulata, Scutellaria baicalensis, Alisma orientalis, angelica sinensis, Ligusticum chuanxiong, Poria cocos, raw Atractylodes macrocephala, cinnamon twig, Panax notoginseng, Pittosporum tobira bark, Eucommia ulmoides salt and Clematis chinensis.

[0011] Furthermore, the various herbs in the formula include the following components in parts by weight: 8-12 parts of Phellodendron chinense, 8-12 parts of red powder, 6-10 parts of frankincense, 3-7 parts of Sanguisorba officinalis, 3-7 parts of elephant skin, 7-11 parts of catechu, 3-7 parts of calomel, 8-12 parts of myrrh, 8-12 parts of dragon bone, 1-5 parts of borneol, and 2-10 parts of sesame oil.

[0012] Preferably, the various herbs in the formula include the following components in parts by weight: 10 parts of Phellodendron chinense, 10 parts of red powder, 8 parts of frankincense, 5 parts of Sanguisorba officinalis, 5 parts of elephant skin, 9 parts of catechu, 5 parts of calomel, 10 parts of myrrh, 10 parts of dragon bone, 3 parts of borneol, and 5 parts of sesame oil.

[0013] The present invention also provides an application of a traditional Chinese medicine composition for treating blood stasis and dampness stagnation type low back pain, the application comprising preparing an oral liquid and a granule preparation.

[0014] The present invention also provides a method for preparing an oral liquid of a Chinese medicine composition for treating blood stasis and dampness resistance type low back pain, the preparation method comprising the following steps:

[0015] (1) Weigh Millettia spatholobi, Scutellaria baicalensis, Orientalis rhizome, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria cocos, Atractylodes macrocephala, Cinnamomum cassia, Notoginseng, Cortex Pittosporum, Eucommia ulmoides, and Radix Clematis chinensis according to a certain weight ratio;

[0016] (2) Decoction different Chinese medicinal materials together, take the supernatant and take it orally.

[0017] The present invention also provides a method for preparing a granule preparation of a Chinese medicine composition for treating blood stasis and dampness resistance type low back pain, the preparation method comprising the following steps:

[0018] (1) Grind Panax notoginseng into fine powder and set aside;

[0019] (2) extracting Millettia spatholobi, Scutellaria baicalensis, Alisma orientalis, Chinese angelica sinensis, Chuanxiong, Poria cocos, Atractylodes macrocephala, Cinnamomum cassia, Pittosporum tobira bark, Eucommia ulmoides salt, and Clematis chinensis with water as solvent, combining the filtrates, concentrating under reduced pressure to a clear paste of a certain relative density, drying, grinding into fine powder, adding Panax notoginseng powder, and mixing evenly;

[0020] (3) Add different types and proportions of excipients to the dry paste powder, mix well, add a wetting agent to make granules, dry, and granulate to obtain the product.

[0021] Preferably, the process route of the granule preparation is as follows Figure 1 shown.

[0022] Preferably, the wetting agent in step (3) is ethanol.

[0023] The beneficial effects achieved by the present invention using the above structure are as follows: (1) The granules of the present invention have low toxicity and side effects, low dependence, and good prognosis; (2) The granules of the present invention are low in price, efficient in preparation, convenient to carry and take, easy to promote, and have a good taste; (3) The present invention provides accurate and efficient treatment for the most common type of low back pain syndrome currently seen in clinical practice.

[0024] The present invention uses twelve kinds of Chinese herbal medicines as the main effective ingredients for treating blood stasis and dampness resistance type low back pain:

[0025] Among them, Millettia reticulata: belongs to the liver and kidney meridians. The nature and flavor are bitter, sweet, and warm. The functions and indications are to nourish blood, activate blood circulation, and dredge collaterals. It is used for irregular menstruation, blood deficiency and sallow complexion, numbness and paralysis, rheumatism and arthralgia. It can not only activate blood circulation and dredge collaterals to relieve pain, but also nourish blood and nourish tendons; Scutellaria baicalensis: The nature and flavor are bitter and cold. It belongs to the lung, gallbladder, spleen, large intestine, and small intestine meridians. The functions and indications are to clear away heat and dampness, purge fire and detoxify, stop bleeding, and stabilize the fetus. It is used for damp-heat, summer heat, chest tightness and nausea, damp-heat fullness, diarrhea, jaundice, lung heat cough, high fever and thirst, blood heat vomiting and epistaxis, carbuncle, sore, and restless fetus; Alisma orientalis: belongs to the kidney and bladder meridians. The nature and flavor are sweet and cold. The functions and indications are to promote urination and clear damp-heat. It is used for urination difficulties, edema, diarrhea, oliguria, phlegm and dizziness, hot stranguria and pain; hyperlipidemia; Angelica sinensis: The nature and flavor are sweet and spicy, and the nature is warm. It enters the liver, heart and spleen meridians. It nourishes and regulates blood, regulates menstruation and relieves pain, moisturizes and lubricates the intestines. It treats irregular menstruation, amenorrhea, abdominal pain, mass accumulation, metrorrhagia; headache due to blood deficiency, dizziness, paralysis; dry bowel and constipation, heaviness after dysentery; carbuncle, sore, and injuries from falls; Chuanxiong: pungent, warm. It enters the liver and gallbladder meridians. It enters the liver, gallbladder and pericardium meridians. It is pungent in nature and warm. It functions to activate blood circulation and qi, dispel wind and relieve pain. It is used for irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to mass accumulation, stabbing pain in the chest and ribs, swelling and pain due to falls, headache, and rheumatic pain; Poria: It enters the heart, lung, spleen and kidney meridians. It promotes diuresis and eliminates dampness, strengthens the spleen, and calms the mind; Raw Atractylodes: It enters the spleen and stomach meridians, tastes bitter, sweet and is warm in nature. It functions to strengthen the spleen and replenish qi, dry dampness and promote diuresis, stop sweating, and stabilize pregnancy; Cinnamon twig: pungent, sweet and warm. It enters the heart, lung and bladder meridians. It has the functions of sweating and relieving muscles, warming and unblocking meridians, assisting yang and transforming qi, and balancing and descending qi; Panax notoginseng: warm in nature, sweet and slightly bitter in taste. It enters the liver and stomach meridians. It has the functions of nourishing blood, resisting inflammation, promoting blood circulation and removing blood stasis; Pittosporum tobira bark: bitter and pungent in taste, neutral in nature. It has the functions of removing rheumatism, unblocking meridians, killing insects and relieving itching, and relieving pain; Salt Eucommia: sweet in nature and warm in taste. It enters the liver and kidney meridians. Functions and indications: nourishing the liver and kidney, strengthening tendons and bones, and stabilizing pregnancy. It is used for low back pain due to kidney deficiency, weakness of tendons and bones, bleeding during pregnancy, restless fetal movement, and hypertension; Clematis: It enters the bladder meridian. It is pungent, salty, and warm in nature. Functions and indications: removing wind and dampness, unblocking meridians and relieving pain. It is used for rheumatic arthralgia, numbness of limbs, cramps of tendons and veins, poor flexion and extension, and bone stuck in the throat. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 Processing route for granule preparations.

[0027] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0028] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0029] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein may be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and are not intended to limit the content of this application.

[0030] The experimental methods in the following examples are conventional methods unless otherwise specified; the experimental materials and test strains used in the following examples are purchased from commercial channels unless otherwise specified.

[0031] Example 1

[0032] A Chinese medicine composition for treating blood stasis and dampness obstruction type low back pain and its application

[0033] The Chinese medicine composition for treating low back pain of blood stasis and dampness obstruction type comprises the following components in parts by weight: 12g Millettia spatholobi, 9g Alisma orientalis, 9g Radix Angelicae Sinensis wine, 9g Rhizoma Chuanxiong, 9g Poria, 9g Atractylodes macrocephala, 6g Cinnamomum cassia twig, 3g Notoginseng, 9g Pittosporum tobira bark, 9g Eucommia ulmoides, 6g Scutellaria baicalensis, and 9g Clematis chinensis.

[0034] In the prescription, Millettia reticulata and Rhizoma Alismatis are the main ingredients. Millettia reticulata can not only invigorate blood circulation, relieve pain, but also nourish blood and strengthen tendons. Rhizoma Alismatis is mildly penetrating and good at promoting diuresis and removing dampness. The combination of the two can promote blood circulation and remove dampness, and they are the main ingredients. Angelica sinensis and Rhizoma Chuanxiong are the assistant ingredients, which can nourish blood, promote blood circulation, and promote qi, moisten dryness, and take into account both qi and blood. It can enhance the effect of the main ingredient in nourishing blood, promoting blood circulation, and removing dampness, and remove blood stasis without hurting the body, and qi and blood can flow naturally; Poria cocos and Atractylodes macrocephala are the assistant ingredients, which can invigorate the spleen and remove dampness, replenish qi and nourish the middle, and enhance the effect of the main ingredient in promoting diuresis and removing dampness, and remove evil without hurting the body; Scutellaria baicalensis is the assistant ingredient, which can clear away heat and dry dampness, and control the heat of the other ingredients. Cinnamon twig, Panax notoginseng, Pittosporum tobira bark, and Eucommia ulmoides are the assistant ingredients. Cinnamon twig enters the bladder meridian to warm yang and transform qi, Panax notoginseng stops bleeding without leaving blood stasis, removes blood stasis without hurting the body, Pittosporum tobira bark relaxes tendons and unblocks meridians, and Eucommia ulmoides can nourish the liver and kidneys and strengthen tendons and bones, without forgetting to treat the root cause. Clematis is the messenger, which enters the bladder meridian and is good at unblocking the twelve meridians to guide the meridians and report to the messenger. Looking at the whole prescription, it is closely tied to the two main lines of "stasis" and "dampness". It does not forget to remove dampness while removing stasis, and does not forget to strengthen the body while removing evil. It treats stasis and dampness together, and plays the role of promoting blood circulation, removing dampness, unblocking meridians and relieving pain.

[0035] like Figure 1 As shown, the preparation method comprises the following steps:

[0036] (1) Weigh Millettia spatholobi, Scutellaria baicalensis, Orientalis rhizome, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria cocos, Atractylodes macrocephala, Cinnamomum cassia, Notoginseng, Cortex Pittosporum, Eucommia ulmoides, and Radix Clematis chinensis according to a certain weight ratio;

[0037] (2) Decoction different Chinese medicinal materials together, take the supernatant and take it orally.

[0038] Example 2

[0039] A Chinese medicine composition for treating blood stasis and dampness obstruction type low back pain and its application

[0040] The Chinese medicine composition for treating low back pain of blood stasis and dampness obstruction type comprises the following components in parts by weight: 12g Millettia spatholobi, 9g Alisma orientalis, 9g Radix Angelicae Sinensis wine, 9g Rhizoma Chuanxiong, 9g Poria, 9g Atractylodes macrocephala, 6g Cinnamomum cassia twig, 3g Notoginseng, 9g Pittosporum tobira bark, 9g Eucommia ulmoides, 6g Scutellaria baicalensis, and 9g Clematis chinensis.

[0041] The preparation method comprises the following steps:

[0042] (1) Grind Panax notoginseng into fine powder and set aside;

[0043] (2) extracting Millettia spatholobi, Scutellaria baicalensis, Alisma orientalis, Chinese angelica sinensis, Chuanxiong, Poria cocos, Atractylodes macrocephala, Cinnamomum cassia, Pittosporum tobira bark, Eucommia ulmoides salt, and Clematis chinensis with water as solvent, combining the filtrates, concentrating under reduced pressure to a clear paste of a certain relative density, drying, grinding into fine powder, adding Panax notoginseng powder, and mixing evenly;

[0044] (3) Add different types and proportions of excipients to the dry paste powder, mix well, add a wetting agent to make granules, dry, and granulate to obtain the product.

[0045] The wetting agent in step (3) is ethanol.

[0046] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0047] The present invention and its embodiments are described above, and such description is not restrictive. The drawings show only one embodiment of the present invention, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design a structure and embodiment similar to the technical solution without creativity, which should belong to the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating blood stasis and dampness obstruction type low back pain, characterized in that: The traditional Chinese medicine composition comprises the following components: Millettia reticulata, scutellaria baicalensis, oriental rhizome, angelica sinensis, ligusticum chuanxiong, tuckahoe, raw atractylodes macrocephala, cassia twig, notoginseng, pittosporum tobira bark, salt eucommia bark and clematis root.

2. A Chinese medicine composition for treating low back pain caused by blood stasis and dampness according to claim 1, characterized in that: The various herbs in the formula include the following components in parts by weight: 8-12 parts of Phellodendron chinense, 8-12 parts of red powder, 6-10 parts of frankincense, 3-7 parts of Sanguisorba officinalis, 3-7 parts of elephant skin, 7-11 parts of catechu, 3-7 parts of calomel, 8-12 parts of myrrh, 8-12 parts of dragon bone, 1-5 parts of borneol, and 2-10 parts of sesame oil.

3. A Chinese medicine composition for treating low back pain caused by blood stasis and dampness according to claim 2, characterized in that: The various herbs in the formula include the following components in parts by weight: 10 parts of Phellodendron chinense, 10 parts of red powder, 8 parts of frankincense, 5 parts of Sanguisorba officinalis, 5 parts of elephant skin, 9 parts of catechu, 5 parts of calomel, 10 parts of myrrh, 10 parts of dragon bone, 3 parts of borneol, and 5 parts of sesame oil.

4. An application of the Chinese medicine composition for treating blood stasis and dampness resistance type low back pain according to claim 3, characterized in that: The application includes preparing oral liquid and granule preparations.

5. A method for preparing the oral liquid of a Chinese medicine composition for treating blood stasis and dampness resistance type low back pain according to claim 4, characterized in that: The preparation method comprises the following steps: (1) Weigh Millettia spatholobi, Scutellaria baicalensis, Orientalis rhizome, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria cocos, Atractylodes macrocephala, Cinnamomum cassia, Notoginseng, Cortex Pittosporum, Eucommia ulmoides, and Radix Clematis chinensis according to a certain weight ratio; (2) Decoction different Chinese medicinal materials together, take the supernatant and take it orally.

6. The method for preparing a granular preparation of a Chinese medicine composition for treating blood stasis and dampness resistance type low back pain according to claim 5, characterized in that: The preparation method comprises the following steps: (1) Grind Panax notoginseng into fine powder and set aside; (2) extracting Millettia spatholobi, Scutellaria baicalensis, Alisma orientalis, Chinese angelica sinensis, Chuanxiong, Poria cocos, Atractylodes macrocephala, Cinnamomum cassia, Pittosporum tobira bark, Eucommia ulmoides salt, and Clematis chinensis with water as solvent, combining the filtrates, concentrating under reduced pressure to a clear paste of a certain relative density, drying, grinding into fine powder, adding Panax notoginseng powder, and mixing evenly; (3) Add different types and proportions of excipients to the dry paste powder, mix well, add a wetting agent to make granules, dry, and granulate to obtain the product.

7. A method for preparing a Chinese medicine composition for treating blood stasis and dampness resistance type low back pain according to claim 6, characterized in that: The wetting agent in step (3) is ethanol.

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