Traditional Chinese medicine composition for treating gout

Abstract

The invention discloses a traditional Chinese medicine composition for treating gout, and belongs to the field of traditional Chinese medicine preparations, the traditional Chinese medicine composition for treating gout comprises the following components by mass: 5-20 g of day lily, 30-50 g of coptis chinensis, 30-50 g of scutellaria baicalensis, 30-50 g of golden cypress, 30-50 g of rheum officinale, 10-30 g of saposhnicovia divaricata, and 10-30 g of radix angelicae pubescentis. The traditional Chinese medicines used in the traditional Chinese medicine composition provided by the invention can effectively treat gout through a synergistic effect after reasonable compatibility, have a good effect of relieving joint symptoms, and particularly have a good treatment effect on damp-heat gout. The colchicine contained in the feed can inhibit the movement and activity of neutrophil. The preparation method has the advantages of simple preparation process, easily available raw materials and low cost.

Description

Technical Field

[0001] The invention belongs to the field of Chinese medicine preparations, and in particular relates to a Chinese medicine composition for treating gout, which has high efficiency and quick effect. Background Art

[0002] Gout is a common and complex type of arthritis that can affect people of all ages, with a higher incidence in men than in women. Gout patients often experience sudden joint pain at night, with acute onset, pain, edema, redness, swelling and inflammation in the joints, and the pain gradually subsides until it disappears, lasting for several days or weeks. Gout attacks are related to the concentration of uric acid in the body. Gout will form urate deposits in the joint cavity, etc., which will cause acute joint pain. The main cause of gout is the consumption of foods rich in purine. There are two main methods for gout: drug therapy and diet therapy. The main drugs for the treatment of gout are non-steroidal anti-inflammatory drugs and glucocorticoids, but drug therapy is currently less used; drinking low-fat foods is a more common treatment method. The prevalence of gout in my country is between 1% and 3%, and it is increasing year by year.

[0003] Gout often occurs suddenly at midnight or early in the morning, with severe joint pain that reaches a peak within a few hours. The affected joints become red, swollen, hot, painful, and dysfunctional. Since there is no particularly good way to deal with this with diet therapy, there are still few effective drugs for gout. Therefore, a drug that can quickly relieve gout symptoms is needed by the market.

[0004] The pain of gout comes from the inflammatory response caused by crystals formed by uric acid in the blood and deposited in the joints. This inflammatory response is the neutrophils trying to remove uric acid. Daylily contains colchicine, a chemical that inhibits microtubule polymerization and blocks the mobility of neutrophils, thereby preventing joint inflammation and relieving symptoms.

[0005] Rhizoma Coptidis, Radix Scutellariae, and Rhizoma Phellodendri all have bitter and cold tastes, and have the effects of clearing away heat and dampness, purging fire and detoxifying. The three often cooperate with each other to enhance the power of clearing heat and detoxifying, and are collectively called the Three Yellows, which can be used to treat damp-heat, chest tightness and nausea due to summer heat, damp-heat fullness, diarrhea, jaundice, lung heat cough, high fever and thirst, blood heat vomiting and bleeding, carbuncle, sore and toxicity, and fetal movement disorder. The three can be used together to enhance their respective anti-inflammatory effects, and have a good effect on treating inflammation and clearing away damp-heat in the triple energizer.

[0006] Daylily has the functions of clearing away heat, promoting diuresis, cooling blood and stopping bleeding. It is mainly used to treat hematuria, bloody stool and irregular menstruation. It is recorded in the Compendium of Materia Medica. Daylily is rich in nutritional value, rich in protein, fat, carbohydrates, etc. It is also called "sedative vegetable". The colchicine contained in it can bind to tubulin dimers, prevent tubulin conversion, reduce the activity, adhesion and chemotaxis of neutrophils by interfering with lysosomal degranulation, and inhibit the migration of granulocytes to the inflammatory area, thereby exerting an anti-inflammatory effect. In addition, it interferes with the expression of intercellular adhesion molecules and selectins, thereby hindering the activation of T lymphocytes and adhesion to endothelial cells, and inhibiting the inflammatory response.

[0007] Fangfeng and Duhuo are pungent and warm in nature, and have the effects of dispelling wind and dampness, relieving numbness and relieving pain. They can be used to treat wind-cold-dampness arthritis, and joint pain, no matter whether it is new or long-term.

[0008] At present, colchicine contained in daylily is mostly used alone as a preventive medicine for gout, and is rarely prepared as a Chinese herbal decoction with comprehensive and good therapeutic effects. There are also no reports on the market of using daylily, Scutellaria baicalensis, Coptis chinensis, and Phellodendron chinense together to treat gout. Summary of the invention

[0009] The present invention provides a Chinese medicine composition for treating gout. After reasonable compatibility, day lily, coptis root, scutellaria, phellodendron, saposhnikovia and angelica dahurica can effectively treat gout through synergistic effect, and have a good effect of relieving joint symptoms, especially for damp-heat gout. In order to achieve the purpose of the present invention, the technical scheme of the present invention is as follows:

[0010] A Chinese medicine composition for treating gout, which is composed of 5-20g of daylily, 30-50g of coptis root, 30-50g of scutellaria root, 30-50g of phellodendron, 10-30g of siler, and 10-30g of angelica root. Preferably, the composition is composed of 10g of daylily, 40g of coptis root, 40g of scutellaria root, 40g of phellodendron, 20g of siler, and 20g of angelica root.

[0011] Further, the preparation method thereof comprises the following steps:

[0012] S1: Take daylily, siler, angelica root, coptis root, scutellaria root and phellodendron according to the above mass, and bake and grind the daylily, siler, siler, coptis root, scutellaria root and phellodendron root into granular powder.

[0013] S2: The medicinal material powder obtained in S1 is decocted, and the obtained solution is concentrated to obtain a composite extract solution, which is a traditional Chinese medicine composition for treating gout.

[0014] As a preferred solution, the sieving in the preparation method S1 uses a 10-30 mesh sieve, preferably a 10-20 mesh sieve.

[0015] Furthermore, in the preparation method, when decocting day lily, coptis root, scutellaria baicalensis, phellodendron, saposhnikovia divaricata and angelica dahurica in a medicine pot, water of 8-12 times the weight of the medicinal materials needs to be added for decocting, and the decocting time is 60-80 minutes.

[0016] Furthermore, in the preparation method S3, when the solution is concentrated after decocting day lily, coptis root, scutellaria baicalensis, phellodendron, saposhnikovia divaricata, and angelica dahurica, the remaining water volume is not less than one-fifteenth of the volume before concentration.

[0017] Furthermore, the Chinese medicine composition for treating gout is used for comprehensive treatment of gout and has a good effect on relieving gout pain and treating gout.

[0018] Furthermore, the Chinese medicine composition for treating gout is in the form of a liquid for oral administration.

[0019] Compared with the prior art, the beneficial effects of the present invention are mainly reflected in: the Chinese medicine composition provided by the present invention can inhibit microtubule polymerization through the colchicine chemical substance therein, block the mobility of neutrophils, thereby preventing joint inflammation to relieve symptoms, and can effectively relieve gout pain; day lily, scutellaria baicalensis, coptis chinensis, and phellodendron chinense have a synergistic effect and obvious anti-inflammatory effect, and the synergistic effect of saposhnikovia divaricata and angelica dahurica can have analgesic, dampness-removing and arthralgia-relieving effects, and has significant efficacy in treating gout; and the preparation process of the present invention is simple, the raw materials are easily available, and the cost is low. DETAILED DESCRIPTION

[0020] The present invention is further explained below with reference to the examples, but the examples do not limit the present invention in any form.

[0021] The daylily used in the embodiments of the present invention was purchased from Anhui Wanfeng Bee Industry Group Co., Ltd.; Scutellaria baicalensis was purchased from Wanxin Pharmaceutical Co., Ltd.; Coptis chinensis was purchased from Shandong Qicai Baicao Pharmaceutical Co., Ltd.; Phellodendron chinense was purchased from Sichuan Qinxinyuan Trading Co., Ltd.; Saposhnikovia divaricata was purchased from Shandong Qicai Baicao Pharmaceutical Co., Ltd.; and Angelica dahurica was purchased from Sichuan Qinxinyuan Trading Co., Ltd.

[0022] Example 1

[0023] Weigh 8g of daylily, 43g of coptis chinensis, 40g of scutellaria baicalensis, 45g of phellodendron chinense, 17g of siler 17g, and dry the daylily, siler 17g, coptis chinensis, scutellaria baicalensis, and phellodendron chinense, then grind them into granular powder and pass them through a 20-mesh sieve. Then add 1700g of water into a medicine pot and boil them. After boiling for 70 minutes, a solution is obtained. The residues are removed and the solution is concentrated to one-fifteenth of the original volume to obtain a decoction of Chinese medicine composition.

[0024] Example 2

[0025] Weigh 18 g of day lily, 38 g of coptis root, 38 g of scutellaria baicalensis, 38 g of phellodendron, 19 g of siler, and 19 g of angelica dahurica to prepare a Chinese medicine composition, and the remaining steps are carried out in the same manner as in Example 1.

[0026] Example 3

[0027] Weigh 10 g of day lily, 40 g of coptis root, 40 g of scutellaria baicalensis, 40 g of phellodendron, 20 g of siler, and 20 g of angelica dahurica to prepare a Chinese medicine composition, and the remaining steps are carried out in the same manner as in Example 1.

[0028] Example 4

[0029] Weigh 10 g of day lily, 40 g of coptis root, 45 g of scutellaria baicalensis, 37 g of phellodendron, 18 g of siler, and 20 g of angelica sinensis to prepare a Chinese medicine composition, and the remaining steps are carried out in the same manner as in Example 1.

[0030] Example 5

[0031] Weigh 15 g of day lily, 39 g of coptis root, 39 g of scutellaria baicalensis, 39 g of phellodendron, 19 g of siler, and 19 g of angelica dahurica to prepare a Chinese medicine composition, and the remaining steps are carried out in the same manner as in Example 1.

[0032] Example 6

[0033] Weigh 10 g of day lily, 33 g of coptis root, 33 g of scutellaria baicalensis, 40 g of phellodendron, 27 g of siler, and 27 g of angelica dahurica to prepare a Chinese medicine composition, and the remaining steps are carried out in the same manner as in Example 1.

[0034] Comparative Example 1

[0035] 170 g of day lily was weighed, dried, crushed into granular powder, passed through a 20-mesh sieve, dissolved, and concentrated to obtain a composite extract solution.

[0036] Comparative Example 2

[0037] 170 g of Coptis chinensis raw material was weighed to prepare extract powder, and the remaining steps were carried out in the same manner as in Comparative Example 1.

[0038] Comparative Example 3

[0039] 170 g of Scutellaria baicalensis radix raw material was weighed to prepare extract powder, and the remaining steps were carried out in the same manner as in Comparative Example 1.

[0040] Comparative Example 4

[0041] 170 g of Phellodendron chinense raw material was weighed to prepare extract powder, and the remaining steps were carried out in the same manner as in Comparative Example 1.

[0042] Comparative Example 5

[0043] Weigh 170 grams of siler raw material to prepare extract powder, and the remaining steps are carried out in the same manner as in Comparative Example 1.

[0044] Comparative Example 6

[0045] Weigh 170 grams of Angelica dahurica raw material to prepare the extract powder, and carry out the remaining steps in the same manner as in Comparative Example 1.

[0046] Drug trials

[0047] The following experimental examples further illustrate that the combined use of day lily, scutellaria, coptis, phellodendron, saposhnikovia and angelica dahurica in the treatment of gout has a more significant therapeutic effect than using one or more of the drugs alone.

[0048] 90 gout mice cultured with monosodium urate (MSU) suspension injected into the joint cavity were randomly divided into 15 groups, namely, a blank control group, Example 1-6 groups and Comparative Example 1-6 groups. The mice were given medication at a dose of 10 g / day according to the decoction of the Example group and the Comparative Example group in the present invention, three times a day, for a medication period of three months. After the expiration, the mice were killed, the mouse kidneys were taken out and made into a solution with 10% saline, diluted 2 times, and the uric acid levels were measured respectively. The uric acid in the deproteinized blood filtrate was oxidized to allantoin and carbon dioxide by tungstic acid in an alkaline solution, and phosphotungstic acid was reduced to tungsten blue in this reaction. The amount of tungsten blue generated was proportional to the uric acid content in the reaction solution, and a colorimetric determination could be performed. The spectrophotometer was used at a length of 660 nm, the light path of the colorimetric cup was 1.0 cm, and the blank tube was adjusted to zero. The serum uric acid content can be obtained by reading the absorbance of each tube.

[0049] Table 1 Results of drug tests on mice in blank control group, examples 1-6 and comparative examples 1-6

[0050]

[0051]

[0052] It can be seen from the above test results that in Example 1-6, day lily, scutellaria, coptis, phellodendron, saposhnikovia, and radix angelicae are used to treat gout mice together, and the uric acid concentration in the blood of mice can be effectively reduced. When taking day lily 10g, coptis 40g, scutellaria 40g, phellodendron 40g, saposhnikovia 20g, and radix angelicae 20g in the Chinese medicine composition, the effect of gout mice cultured by injecting sodium urate in the joint cavity is the best. Compared with the blank control group, the uric acid concentration in the blood of mice in the comparative example 1-6 group and the embodiment 1-6 group has decreased, and the uric acid concentration in the blood of mice in the embodiment 1-6 group is significantly lower than the uric acid concentration in the blood of mice in the comparative example 1-6 group. The Chinese medicine composition provided by the present invention is through reasonable compatibility, and the drug effect is enhanced by synergistic effect, and the uric acid concentration in the blood can be significantly reduced, and gout can be treated well, and the therapeutic effect of gout is better than using one or two of them alone.

[0053] The above only lists the preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereto. Any changes made by those skilled in the art within the scope of the claims of the present invention shall fall within the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating gout, characterized in that: The composition is prepared from the following raw materials in parts by weight: 5-20 parts of day lily, 30-50 parts of coptis root, 30-50 parts of scutellaria baicalensis, 30-50 parts of phellodendron amurense, 10-30 parts of siler, and 10-30 parts of angelica dahurica.

2. A Chinese medicine composition for treating gout according to claim 1, characterized in that: The composition is preferably made of the following raw materials in parts by weight: 10-15 parts of day lily, 40-45 parts of coptis root, 40-45 parts of scutellaria baicalensis, 40-45 parts of phellodendron amurense, 20-25 parts of siler, and 20-25 parts of angelica dahurica.

3. A Chinese medicine composition for treating gout according to claim 1, characterized in that: The preparation method comprises the following steps: S1: taking daylily, coptis root, scutellaria root, phellodendron, siler, and angelica root according to the weight proportions of claim 1, and baking and crushing the daylily, siler, scutellaria root, and siler into granular powder; S2: The medicinal material powder obtained in S1 is decocted, and the obtained solution is concentrated to obtain a composite extract solution, which is a traditional Chinese medicine composition for treating gout.

4. The method for preparing the Chinese medicine composition according to claim 2, characterized in that: The sieving in S1 uses a 10-30 mesh sieve, preferably a 10-20 mesh sieve.

5. The method for preparing the Chinese medicine composition according to claim 2, characterized in that: When decocting the S2 medicinal material powder, add water in an amount of 8 to 12 times the weight of the medicinal material and boil for 60 to 80 minutes.

6. The method for preparing the Chinese medicine composition according to claim 2, characterized in that: When the decoction solution of day lily, coptis root, scutellaria baicalensis, phellodendron, saposhnikovia divaricata and angelica pubescens obtained in S2 is concentrated, the final remaining solution volume is not less than one fifteenth of the volume of the solution before concentration.

7. A Chinese medicine composition for treating gout according to claim 1, characterized in that: The Chinese medicine composition is a liquid for oral administration and is prepared into an oral liquid preparation through pharmaceutical technology.

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