Medical water equipment

Abstract

The invention provides medical water equipment, and belongs to the technical field of water production equipment. According to the equipment, a set of hollow fiber membrane degassing and degerming device is additionally arranged at the rear end of two-stage reverse osmosis and EDI water treatment, so that the water quality of medical water can be greatly improved. Experimental verification shows that the dissolved oxygen index of the raw water is 9200PPb before treatment, and the dissolved oxygen index of the raw water is below 7ppb after the raw water is treated by the method disclosed by the invention; the conductivity of the raw water is 0.7-0.8 [mu] s / cm, and reaches 0.1-0.2 [mu] s / cm after the raw water is treated by the method. By removing the dissolved oxygen in the water, various microorganisms in the water cannot survive in an anaerobic state. According to the invention, the effluent quality is fully improved, the oxygen environment for microorganism breeding is avoided, and the device has outstanding technical advantages and good operation performance.

Description

Technical Field

[0001] The invention relates to the technical field of water production equipment, in particular to medical water production equipment. Background Art

[0002] Medical water is water that has been fully purified to remove microorganisms and contaminants. It is widely used in the production process of medicines, pharmaceutical excipients and pharmaceutical packaging materials, as well as in the preparation of pharmaceutical preparations. Medical water can be divided into drinking water, purified water, water for injection, etc. according to the cleanliness level. In addition to the relatively low cleanliness level of drinking water, purified water and water for injection are generally purified by distillation, ion exchange, reverse osmosis and other methods.

[0003] The quality standards for medical water are very strict, especially for water for injection, which must meet the requirements of bacterial endotoxin test, and the conductivity is required to be less than a certain threshold. In the prior art, the typical preparation method of medical water is a combination of reverse osmosis and EDI. Reverse osmosis is a membrane separation technology that uses the selective permeability of a semipermeable membrane to allow water molecules to flow from one side of a high-concentration solution through a semipermeable membrane under pressure to the other side of a low-concentration solution, while ions, organic matter, bacteria, etc. dissolved in water are retained on the other side of the semipermeable membrane, thereby achieving water purification. EDI technology is a water treatment technology that combines electrodialysis technology with ion exchange technology. It applies an electric field between an ion exchange membrane and an ion selective membrane, uses the action of the electric field to cause ions in the water to migrate in a directional manner, and removes ions through an electrochemical reaction. In the prior art, this type of purification technology is relatively mature, however, the quality of the resulting pure water is still relatively high in terms of dissolved oxygen and conductivity, especially when the dissolved oxygen index is too high, it is easy to provide conditions for the growth of microorganisms, greatly affecting water quality and safety. Summary of the invention

[0004] The technical problem to be solved by the present invention is that conventional pure water equipment only adopts a process combining reverse osmosis and EDI, and the quality of the obtained pure water is still relatively high in terms of dissolved oxygen and conductivity.

[0005] In order to achieve the above technical objectives, the present invention adopts the following technical solutions: A medical water device comprises a two-stage reverse osmosis unit and an EDI device, wherein a hollow fiber membrane degassing and sterilizing device is arranged behind the two-stage reverse osmosis unit and the EDI device.

[0006] Preferably, a plurality of hollow fiber membrane filters are connected in series in the hollow fiber membrane degassing and sterilization device, and hollow fiber membrane materials are loaded in the hollow fiber membrane filters.

[0007] Preferably, the number of the hollow fiber membrane filters is 3.

[0008] Preferably, the hollow fiber membrane material is prepared by the following method: polyacrylonitrile, polyvinylidene fluoride and cellulose acetate are mixed to obtain a mixed raw material, the mixed raw material is dissolved in NMMO solvent to obtain a mixed solution, sodium nitrate and disodium ethylenediaminetetraacetate are added, the mixture is allowed to stand and degas after mixing to obtain a casting solution, diethylene glycol and propylene carbonate are mixed to obtain a core liquid, and then a hollow fiber membrane spinning machine is used to spin and form a membrane.

[0009] Preferably, the mass ratio of polyacrylonitrile, polyvinylidene fluoride and cellulose acetate is 1~2:4~5:0.5~1.

[0010] Preferably, in the mixed solution, the concentration of the mixed raw materials is 0.3-0.4 g / mL.

[0011] Preferably, after obtaining the mixed solution, the temperature is maintained at 55-65° C. for 1 h under ultrasonic oscillation, the pH is adjusted to 7.8-8.0, and then sodium nitrate and disodium ethylenediaminetetraacetic acid are added.

[0012] Preferably, the mass ratio of polyacrylonitrile, polyvinylidene fluoride, cellulose acetate, sodium nitrate and disodium ethylenediaminetetraacetate is 1-2:4-5:0.5-1:0.2-0.3:0.1-0.2.

[0013] Preferably, the casting solution also contains 0.08-0.15 g / L PEG4000.

[0014] Preferably, the device further comprises a storage tank, which receives effluent from the hollow fiber membrane degassing and sterilization device, and the storage tank is sealed with nitrogen.

[0015] The present invention provides a medical water equipment. The equipment is equipped with a set of hollow fiber membrane degassing and sterilization devices at the rear end of two-stage reverse osmosis and EDI water treatment, which can greatly improve the water quality of medical water. Experimental verification shows that the dissolved oxygen index of raw water is 9200PPb before treatment, and reaches below 7ppb after treatment by the present invention; the conductivity of raw water is 0.7~0.8μs / cm, and reaches 0.1~0.2μs / cm after treatment by the present invention. By removing dissolved oxygen in water, various microorganisms in water cannot survive in an anaerobic state. The present invention fully improves the effluent water quality and eliminates the oxygen environment for the growth of microorganisms, and has outstanding technical advantages and good operating performance. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a front view of the hollow fiber membrane degassing and sterilization device in the present invention.

[0017] Figure 2 It is a rear view of the hollow fiber membrane degassing and sterilization device in the present invention.

[0018] Figure 3 It is a left side view of the hollow fiber membrane degassing and sterilization device in the present invention.

[0019] Figure 4 It is a right side view of the hollow fiber membrane degassing and sterilization device in the present invention.

[0020] Figure 5 It is a top view of the hollow fiber membrane degassing and sterilization device in the present invention.

[0021] Figure 6 This is the first working flow diagram of the deoxidation membrane in the present invention.

[0022] Figure 7 This is the second working flow diagram of the deoxidation membrane in the present invention.

[0023] Figure 8 This is a physical picture of the hollow fiber membrane degassing and sterilization device in the present invention. DETAILED DESCRIPTION

[0024] The specific embodiments of the present invention will be described in detail below. In order to avoid too much unnecessary details, the well-known structures or functions will not be described in detail in the following examples. The approximate language used in the following examples can be used for quantitative expression, indicating that the quantity can be allowed to have a certain change without changing the basic function. Unless otherwise defined, the technical and scientific terms used in the following examples have the same meaning as those generally understood by those skilled in the art to which the present invention belongs.

[0025] Example 1 A medical water device comprises a two-stage reverse osmosis unit and an EDI device, wherein a hollow fiber membrane degassing and sterilizing device is arranged behind the two-stage reverse osmosis unit and the EDI device.

[0026] The end of the purified water storage tank is subjected to a head-shaking operation, and a set of hollow fiber membrane degassing and sterilization device is installed. After the purified water is deoxygenated by the hollow fiber membrane degassing and sterilization device, qualified deoxygenated water is obtained. The deoxygenated water is pumped into the rear storage tank and sealed with nitrogen to prevent the deoxygenated water from dissolving oxygen again. An online dissolved oxygen meter is installed at the end of the device to monitor the deoxygenated water index status in real time. The technical indicators are shown in Tables 1 and 2 below.

[0027] Table 1 Raw material purified water indicators Water use mode of production line: intermittent.

[0028] Deoxygenated water storage method: nitrogen sealed in tanks.

[0029] Deoxygenated water index requirements: dissolved oxygen content ≤ 7ppb.

[0030] Table 2 Deoxygenated water detection indicators Actual operation shows that the dissolved oxygen content of the outlet water of the equipment of the present invention is continuously and stably below 7ppb after 168 hours of continuous operation test; the dissolved oxygen content of the inlet water of the equipment is 9200ppb, the dissolved oxygen content of the outlet water is 5.3ppb, and the deoxygenation rate is above 99.9%.

[0031] The degassing and sterilizing device added in the present invention is efficient, fast and stable. After the pure water is degassed, the dissolved oxygen content in the water is lower than 7 μg / L, so that the production water has almost no oxidation reaction. After the carbon dioxide is removed, the conductivity of the pure water is very low.

[0032] Example 2 A medical water device comprises a two-stage reverse osmosis unit and an EDI device, wherein a hollow fiber membrane degassing and sterilizing device is arranged after the two-stage reverse osmosis unit and the EDI device. Among them, a plurality of hollow fiber membrane filters are connected in series in the hollow fiber membrane degassing and sterilizing device, and a hollow fiber membrane material is loaded in the hollow fiber membrane filter. The number of the hollow fiber membrane filters is 3. The hollow fiber membrane material is prepared by the following method: polyacrylonitrile, polyvinylidene fluoride, and cellulose acetate are mixed to obtain a mixed raw material, the mixed raw material is dissolved in an NMMO solvent to obtain a mixed solution, sodium nitrate and disodium ethylenediaminetetraacetate are added, and after mixing, the mixture is allowed to stand for degassing to obtain a casting solution, diethylene glycol is mixed with propylene carbonate to obtain a core liquid, and then a hollow fiber membrane spinning machine is used to spin and form a membrane. In the mixed solution, the concentration of the mixed raw material is 0.3~0.4g / mL. After obtaining the mixed solution, the temperature is maintained at 55-65°C for 1 h under ultrasonic oscillation, the pH is adjusted to 7.8-8.0, and then sodium nitrate and disodium ethylenediaminetetraacetic acid are added. The mass ratio of polyacrylonitrile, polyvinylidene fluoride, cellulose acetate, sodium nitrate, and disodium ethylenediaminetetraacetic acid is 1-2:4-5:0.5-1:0.2-0.3:0.1-0.2. The casting solution also contains 0.08-0.15 g / L PEG4000. The device also includes a storage tank, which receives the effluent from the hollow fiber membrane degassing and sterilization device, and the storage tank is encapsulated by nitrogen.

[0033] The embodiments of the present invention are described in detail above, but the contents are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the scope of the present invention shall be included in the protection scope of the present invention.

Claims

1. A medical water device, comprising a two-stage reverse osmosis unit and an EDI device, characterized in that: A hollow fiber membrane degassing and sterilization device is arranged after the two-stage reverse osmosis unit and the EDI device.

2. The medical water equipment according to claim 1, characterized in that: A plurality of hollow fiber membrane filters are connected in series in the hollow fiber membrane degassing and sterilization device, and hollow fiber membrane materials are loaded in the hollow fiber membrane filters.

3. The medical water equipment according to claim 2, characterized in that: The number of the hollow fiber membrane filters is 3.

4. The medical water equipment according to claim 2, characterized in that: The hollow fiber membrane material is prepared by the following method: polyacrylonitrile, polyvinylidene fluoride and cellulose acetate are mixed to obtain a mixed raw material, the mixed raw material is dissolved in NMMO solvent to obtain a mixed solution, sodium nitrate and disodium ethylenediaminetetraacetate are added, and the mixture is allowed to stand for degassing after mixing to obtain a casting solution, diethylene glycol and propylene carbonate are mixed to obtain a core liquid, and then a hollow fiber membrane spinning machine is used to spin and form a membrane.

5. The medical water equipment according to claim 4, characterized in that: The mass ratio of polyacrylonitrile, polyvinylidene fluoride and cellulose acetate is 1~2:4~5:0.5~1.

6. The medical water equipment according to claim 5, characterized in that: In the mixed solution, the concentration of the mixed raw materials is 0.3-0.4 g / mL.

7. The medical water equipment according to claim 6, characterized in that: After obtaining the mixed solution, the temperature is maintained at 55-65°C for 1 h under ultrasonic oscillation, the pH is adjusted to 7.8-8.0, and then sodium nitrate and disodium ethylenediaminetetraacetic acid are added.

8. The medical water equipment according to claim 7, characterized in that: The mass ratio of polyacrylonitrile, polyvinylidene fluoride, cellulose acetate, sodium nitrate and disodium ethylenediaminetetraacetate is 1~2:4~5:0.5~1:0.2~0.3:0.1~0.

2.

9. The medical water equipment according to claim 8, characterized in that: The casting solution also contains 0.08-0.15 g / L of PEG4000.

10. The medical water equipment according to claim 1, characterized in that: The equipment further comprises a storage tank, which receives effluent from the hollow fiber membrane degassing and sterilization device, and the storage tank is sealed by nitrogen.

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