High-stability short-wave infrared fluorescent dye J aggregate and application thereof in biological imaging
By designing the compound A-I and its dye J aggregate based on ESi5, the problem of poor stability of existing SWIR organic fluorescent materials is solved, and the effects of high-light/chemical/thermal stability and dual-channel imaging are achieved.
Patent Information
- Application Number
- CN202411596171.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-08
- Publication Date
- 2025-02-18
AI Technical Summary
The existing short-wave infrared interval (SWIR) organic fluorescent materials have poor stability and are susceptible to endogenous/light-induced reactive oxygen failure, and the hydrophobicity of the conjugated skeleton causes electron delocalization in water, affecting its photophysical properties.
By designing a compound A-I and its dye J aggregate based on a near-infrared high brightness long wavelength fluorescent dye dibenzosilodamine (ESi5), the hydrophobicity of the near-infrared dye is used to introduce hydrophilic groups, and through hydrophilic mutualism, the hydrophobicity of the near-infrared dye is used to introduce hydrophilic groups. The action regulates the dye aggregation form and achieves precise regulation of H aggregation, monomer and J aggregation form.
High light/chemical/thermal stability in aqueous solution, with two red shifted absorption peaks and one blue shifted absorption peak, suitable for dual-channel fluorescence imaging and photoacoustic imaging, showing good biocompatibility and stability .
Smart Images
Figure CN119462723A_ABST