Sample analyzer and position debugging method of ultrasonic vibration part of sample analyzer

Abstract

The invention is applicable to the field of in-vitro diagnostic equipment, and discloses a sample analyzer. The sample analyzer comprises a sample distribution device, a reagent distribution device, a determination device, an ultrasonic device, a first solid reference piece and a control device, the ultrasonic device comprises an ultrasonic transducer, an ultrasonic vibration piece and a driving mechanism, and the ultrasonic vibration piece is provided with a positioning part for calibration and positioning; at least one first reference position is formed on the first solid reference piece; the control device is configured to control the driving mechanism to drive the positioning part to move from the first preset position to the first reference position, obtain working parameters of the ultrasonic device in the process that the positioning part moves towards the first reference position, and control the ultrasonic device when the obtained working parameters of the ultrasonic device meet preset conditions. And obtaining the position information of the first ultrasonic working position based on the distance information of the positioning part moving from the first preset position to the first reference position. Automatic debugging of the position of the ultrasonic vibration part is achieved.

Description

Technical Field

[0001] The present invention relates to the field of in vitro diagnostic equipment, and in particular to a sample analyzer and a method for adjusting the position of an ultrasonic vibrator in the sample analyzer. Background Art

[0002] A sample analyzer provided by the related art is provided with an ultrasonic device for transmitting ultrasonic waves to a target liquid to achieve ultrasonic mixing or ultrasonic cleaning. The ultrasonic device includes an ultrasonic transducer, an ultrasonic vibrator, and a driving mechanism, and the driving mechanism is used to drive the ultrasonic vibrator to move to an ultrasonic working position to perform ultrasonic work. When installing or maintaining the sample analyzer, the position of the ultrasonic vibrator needs to be debugged.

[0003] In the related art, the position debugging of the ultrasonic vibrator mainly adopts the manual debugging method, that is, the ultrasonic vibrator is driven to move by the manual control driving mechanism, and the moving position of the ultrasonic vibrator is observed by naked eyes to judge whether the ultrasonic vibrator has moved to the ultrasonic working position. The manual debugging method has the following problems in specific applications: the operation is cumbersome, it takes up a lot of time and energy of the operator, and it is easy to have deviations. If there is a deviation, it is necessary to stop the machine and manually re-debug it. Summary of the invention

[0004] The first object of the present invention is to provide a sample analyzer, which aims to solve the technical problem of troublesome position adjustment of ultrasonic vibrating parts in the related art.

[0005] To achieve the above object, the present invention provides a solution: a sample analyzer, comprising:

[0006] a sample dispensing device, the sample dispensing device being used to dispense at least a portion of the sample in the sample container to a reaction container;

[0007] a reagent dispensing device, the reagent dispensing device being used to dispense at least part of the reagent in the reagent container into the reaction container;

[0008] a measuring device for performing a sample measurement on a reaction solution made of at least a mixture of a sample and a reagent in the reaction container;

[0009] An ultrasonic device, comprising an ultrasonic transducer, an ultrasonic vibrator and a driving mechanism, wherein the ultrasonic vibrator is connected to the ultrasonic transducer to generate ultrasonic vibration under the drive of the ultrasonic transducer, the driving mechanism is connected to the ultrasonic transducer and / or the ultrasonic vibrator to at least drive the ultrasonic vibrator to move to a first ultrasonic working position to perform ultrasonic work, and the ultrasonic vibrator has a positioning portion for calibration and positioning;

[0010] a first solid reference piece, wherein the first solid reference piece forms at least one first reference position, and position information of the first reference position is different from position information of the first ultrasonic working position, and when the ultrasonic device moves to the first reference position, the working parameters of the ultrasonic device meet a preset condition;

[0011] a control device, the control device being configured to: control the driving mechanism to drive the positioning part to move from a first preset position toward the first reference position, obtain working parameters of the ultrasonic device during the movement of the positioning part toward the first reference position, and when the working parameters of the ultrasonic device obtained meet preset conditions, obtain position information of the first ultrasonic working position based on distance information of the positioning part moving from the first preset position to the first reference position;

[0012] The position information of the first ultrasonic working position includes at least one of the following information: distance information of the positioning unit moving from the first preset position to the first ultrasonic working position, and coordinate information of the first ultrasonic working position in a preset coordinate system.

[0013] As an embodiment, the first preset position includes one of the following positions: an initial position of the positioning unit, a position having determined coordinate information in a preset coordinate system, and a position having determined distance information relative to the initial position of the positioning unit.

[0014] As an implementation manner, the operating parameter includes at least one of a phase difference between current and voltage, an amplitude of current, an amplitude of voltage, an amplitude of power, and an amplitude of impedance.

[0015] As an embodiment, the at least one first reference position includes at least one first vertical reference position and / or at least one first horizontal reference position;

[0016] The obtaining the position information of the first ultrasonic working position based on the distance information of the positioning part moving from the first preset position to the first reference position includes:

[0017] Based on the distance information of the positioning unit moving from the first preset position to the first vertical reference position, the vertical position information of the first ultrasonic working position is obtained; and / or based on the distance information of the positioning unit moving from the first preset position to the first horizontal reference position, the horizontal position information of the first ultrasonic working position is obtained;

[0018] The position information of the first ultrasonic working position is obtained based on the vertical position information of the first ultrasonic working position and / or the horizontal position information of the first ultrasonic working position.

[0019] As an embodiment, the at least one first reference position includes at least two first horizontal reference positions;

[0020] The method of obtaining the horizontal position information of the first ultrasonic working position based on the distance information of the positioning part moving from the first preset position to the first horizontal reference position includes: obtaining the horizontal position information of the first ultrasonic working position based on the distance information of the positioning part moving from the first preset position to each of the first horizontal reference positions.

[0021] As an implementation manner, the first reference position includes two first horizontal reference positions, and the horizontal position of the first ultrasonic working position is located on a line connecting the two first horizontal reference positions;

[0022] The obtaining the horizontal position information of the first ultrasonic working position based on the distance information of the positioning unit moving from the first preset position to each of the first horizontal reference positions includes:

[0023] First, controlling the driving mechanism to drive the positioning portion to move between the two first horizontal reference positions;

[0024] Then controlling the driving mechanism to drive the positioning portion to move toward the first horizontal reference position, and obtaining the working parameters of the ultrasonic device during the movement of the ultrasonic vibrator toward the first horizontal reference position;

[0025] When the working parameters of the ultrasonic transducer are obtained to meet the preset conditions, the driving mechanism is controlled to drive the positioning part to move toward another first horizontal reference position, and the working parameters of the ultrasonic device are obtained during the movement of the positioning part toward the first horizontal reference position. When the working parameters of the ultrasonic device are obtained to meet the preset conditions, the horizontal position information of the first ultrasonic working position is obtained based on the distance information of the positioning part moving to the two first horizontal reference positions.

[0026] As an implementation manner, the at least one first reference position includes at least one first vertical reference position and at least one first horizontal reference position, and the controller is further configured to: first obtain vertical position information of the first ultrasonic working position, and then obtain horizontal position information of the first ultrasonic working position;

[0027] Before controlling the driving mechanism to drive the positioning portion to move toward the first horizontal reference position, controlling the driving mechanism to drive the positioning portion to move to a target position, at which the vertical distance from the positioning portion to the first preset position is greater than the vertical distance from the first vertical reference position to the first preset position.

[0028] As an embodiment, the first solid reference member includes a mixing seat, and the mixing seat is formed with a receiving hole for carrying the reaction container;

[0029] The ultrasonic vibrator is used to ultrasonically mix the target liquid in the reaction container at the first ultrasonic working position, and the target liquid is one of a sample, a reagent, and a mixed liquid containing at least the sample and the reagent.

[0030] As an implementation manner, the first reference position includes a first vertical reference position and two first horizontal reference positions;

[0031] The first vertical reference position is located on the top surface of the mixing seat;

[0032] The two first horizontal reference positions are both located on the inner side wall of the accommodating hole, and the two first horizontal reference positions are located on the same diameter of the accommodating hole.

[0033] As an embodiment, the driving mechanism is further used to drive the ultrasonic vibrator to move to a second ultrasonic working position for operation, and position information of the second ultrasonic working position is different from position information of the first ultrasonic working position;

[0034] The sample analyzer further includes a second solid reference member, the second solid reference member is formed with at least one second reference position, and position information of the second reference position is different from position information of the second ultrasonic working position;

[0035] The controller is further configured to: control the driving mechanism to drive the positioning part to move from the second preset position toward the second reference position, obtain the working parameters of the ultrasonic device during the movement of the positioning part toward the second reference position, and when the working parameters of the ultrasonic device obtained meet the preset conditions, obtain the position information of the second ultrasonic working position based on the distance information of the positioning part moving from the first preset position to the second reference position;

[0036] Wherein, the second solid reference member comprises a cleaning pool, and the cleaning pool is used to contain a cleaning liquid to clean the ultrasonic vibrating member located at the second ultrasonic working position;

[0037] The location information of the second preset location is the same as or different from the location information of the first preset location.

[0038] As an implementation manner, the second preset position is an initial position of the positioning portion;

[0039] The initial position is located directly above the second ultrasonic working position;

[0040] The second reference position includes a second vertical reference position formed on the top surface of the cleaning tank;

[0041] The obtaining the position information of the second ultrasonic working position based on the distance information of the positioning part moving from the second preset position to the second reference position includes: obtaining the position information of the second ultrasonic working position based on the distance information of the positioning part moving from the second preset position to the second vertical reference position.

[0042] As an embodiment, the driving mechanism is further used to drive the ultrasonic vibrator to move to the third ultrasonic working position for operation, and the position information of the third ultrasonic working position is different from the position information of the first ultrasonic working position;

[0043] The sample analyzer further includes a third solid reference piece, the third solid reference piece is formed with at least one third reference position, the third reference position is arranged corresponding to the third ultrasonic working position, and the position information of the third reference position is different from the position information of the third ultrasonic working position;

[0044] The controller is further configured to: control the driving mechanism to drive the positioning part to move from a third preset position toward the third reference position, obtain working parameters of the ultrasonic device during the movement of the positioning part toward the third reference position, and when the working parameters of the ultrasonic device obtained meet preset conditions, obtain position information of the third ultrasonic working position based on distance information of the positioning part moving from the first preset position to the third reference position;

[0045] The third solid reference piece includes a reagent loading device, the reagent loading device is formed with a receiving groove for receiving the reagent container, and the ultrasonic vibrator is used to ultrasonically mix the reagent in the reagent container at the third ultrasonic working position;

[0046] The location information of the third preset location is the same as or different from the location information of the first preset location.

[0047] A second object of the present invention is to provide a method for adjusting the position of an ultrasonic vibrator in a sample analyzer, the method comprising the following steps:

[0048] Controlling the driving mechanism of the ultrasonic device to drive the positioning portion of the ultrasonic vibrator to move from a first preset position toward a first reference position of the first solid reference member;

[0049] acquiring working parameters of the ultrasonic device during the process of the positioning portion moving toward the first reference position;

[0050] When it is obtained that the working parameters of the ultrasonic device meet the preset conditions, the position information of the first ultrasonic working position is obtained based on the distance information of the positioning part moving from the first preset position to the first reference position;

[0051] The position information of the first ultrasonic working position includes at least one of the following information: distance information of the positioning unit moving from the first preset position to the first ultrasonic working position, and coordinate information of the first ultrasonic working position in a preset coordinate system.

[0052] As an embodiment, the first preset position includes one of the following positions: an initial position of the positioning unit, a position having determined coordinate information in a preset coordinate system, a position having determined distance information relative to the initial position; and / or,

[0053] The operating parameter includes at least one of a phase difference between current and voltage, an amplitude of current, an amplitude of voltage, an amplitude of power, and an amplitude of impedance.

[0054] As an embodiment, the at least one first reference position includes at least one first vertical reference position and / or at least one first horizontal reference position;

[0055] The obtaining the position information of the first ultrasonic working position based on the distance information of the positioning part moving from the first preset position to the first reference position includes:

[0056] Based on the distance information of the positioning unit moving from the first preset position to the first vertical reference position, the vertical position information of the first ultrasonic working position is obtained; and / or based on the distance information of the positioning unit moving from the first preset position to the first horizontal reference position, the horizontal position information of the first ultrasonic working position is obtained;

[0057] The position information of the first ultrasonic working position is obtained based on the vertical position information of the first ultrasonic working position and / or the horizontal position information of the first ultrasonic working position.

[0058] As an embodiment, the at least one first reference position includes at least two first horizontal reference positions;

[0059] The method of obtaining the horizontal position information of the first ultrasonic working position based on the distance information of the positioning part moving from the first preset position to the first horizontal reference position includes: obtaining the horizontal position information of the first ultrasonic working position based on the distance information of the positioning part moving from the first preset position to each of the first horizontal reference positions.

[0060] As an embodiment, the first solid reference member includes a mixing seat, the mixing seat is formed with a receiving hole for carrying the reaction container, the ultrasonic vibrator is used to ultrasonically mix the target liquid in the reaction container at the first ultrasonic working position, and the target liquid is one of a sample, a reagent, and a mixed liquid containing at least the sample and the reagent; and / or,

[0061] The position debugging method of the ultrasonic vibrator also includes the following steps: controlling the driving mechanism to drive the positioning part to move from the first preset position toward the second reference position of the second fixed reference part, obtaining the working parameters of the ultrasonic device during the movement of the positioning part toward the second reference position, and when the obtained working parameters of the ultrasonic device meet the preset conditions, based on the distance information of the positioning part moving from the second preset position to the second reference position, obtaining the position information of the second ultrasonic working position, wherein the second solid reference part includes a cleaning tank, and the cleaning tank is used to contain cleaning liquid to clean the ultrasonic vibrator located at the second ultrasonic working position, and the position information of the second preset position is the same as or different from the position information of the first preset position.

[0062] The sample analyzer and the method for debugging the position of the ultrasonic vibrator in the sample analyzer provided by the present invention form a first reference position corresponding to the first ultrasonic working position on the first solid reference part, and use the different working parameters of the ultrasonic device when the positioning part on the ultrasonic vibrator contacts the air and contacts the solid ultrasonic device when the ultrasonic device is working to distinguish whether the positioning part contacts the first solid reference part, so as to obtain the distance information of the positioning part moving from the first preset position to the first reference position, and then obtain the position information of the first ultrasonic working position according to the distance information, thereby realizing the automatic debugging of the position of the ultrasonic vibrator. Since the debugging process can be automatically performed by the sample analyzer according to the set program without the need for manual operation by the operator, the operation process of the ultrasonic vibrator position debugging is effectively simplified, and the time and energy occupied by the operator during the debugging process are reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0063] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying creative work.

[0064] Figure 1 is a schematic diagram of the composition of a sample analyzer provided by an embodiment of the present invention;

[0065] Figure 2is a schematic diagram of the structure of a sample analyzer provided by an embodiment of the present invention;

[0066] Figure 3 is a schematic diagram of the motion trajectory of the ultrasonic vibrator provided in an embodiment of the present invention;

[0067] Figure 4 It is a schematic diagram of the vertical position debugging movement of the ultrasonic vibrator at the first ultrasonic position provided by an embodiment of the present invention;

[0068] Figure 5 is a schematic diagram of the horizontal position debugging movement of the ultrasonic vibrator provided by an embodiment of the present invention at a first ultrasonic position;

[0069] Figure 6 is a schematic diagram of ultrasonic mixing of a target liquid by an ultrasonic device provided in an embodiment of the present invention;

[0070] Figure 7 It is a schematic diagram of the composition of the control device provided in an embodiment of the present invention.

[0071] Description of the accompanying drawings: 10, sample analyzer; 100, ultrasonic device; 110, ultrasonic transducer; 111, piezoelectric ceramic component; 120, ultrasonic vibrator; 121, positioning unit; 130, driving mechanism; 131, rocker arm; 200, control device; 210, ultrasonic control board; 220, main control board; 300, sample dispensing device; 400, reagent dispensing device; 500, measuring device; 600, reagent loading device; 700, incubation device; 710, first solid reference member; 711, first Reference position; 7111, first vertical reference position; 7112, first horizontal reference position; 712, first ultrasonic working position; 800, transfer device; 900, reaction container providing device; 101, sample management device; 102, sample delivery device; 103, magnetic separation device; 104, initial position; 105, second solid reference piece; 1051, second reference position; 1052, second vertical reference position; 1053, second ultrasonic working position; 20, target liquid; 30, reaction container. DETAILED DESCRIPTION

[0072] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0073] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back, etc.) are only used to explain the relative position relationship, movement status, etc. between the components in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0074] It should also be noted that when an element is referred to as being "fixed on" or "disposed on" another element, it may be directly on the other element or there may be an intermediate element at the same time. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or may be indirectly connected to the other element through an intermediate element.

[0075] In addition, the descriptions of "first", "second", etc. in the present invention are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on the ability of ordinary technicians in the field to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0076] Prior to this application, there was no precedent for automatic debugging of the position of ultrasonic vibrating parts in sample analyzers, and all debugging was done manually. There was also no precedent for automatic debugging of other moving components using ultrasonic function, and all of them used the principle of capacitance debugging, which requires that both the moving component and the reference part are made of metal materials. This solution uses ultrasonic function debugging, and there is no requirement for the material of the reference part, as long as it is solid.

[0077] like Figures 1 to 7 As shown, the sample analyzer 10 provided in the embodiment of the present invention includes an ultrasonic device 100, and the ultrasonic device 100 includes an ultrasonic transducer 110, an ultrasonic vibrator 120 and a driving mechanism 130. The ultrasonic vibrator 120 is connected to the ultrasonic transducer 110 to generate ultrasonic vibration under the drive of the ultrasonic transducer 110, and the driving mechanism 130 is connected to the ultrasonic transducer 110 and / or the ultrasonic vibrator 120 to at least drive the ultrasonic vibrator 120 to move to the first ultrasonic working position 712 for ultrasonic work. The ultrasonic transducer 110 is an energy conversion device, which is mainly used to convert the electrical power input thereto into mechanical power (i.e., ultrasonic waves) and then transmit it out. The driving mechanism 130 is used to drive the ultrasonic vibrator 120 to move, so that the ultrasonic vibrator 120 moves to different positions to perform different operations.

[0078] As an implementation mode, the ultrasonic transducer 110 includes a piezoelectric ceramic component 111. The piezoelectric ceramic component 111 is a component made of an electronic ceramic material having piezoelectric and sensitive properties, and can realize mutual conversion between mechanical energy and electrical energy.

[0079] As an implementation mode, the ultrasonic device 100 is used to transmit ultrasonic waves to the target liquid 20 to achieve ultrasonic mixing of the target liquid 20. The target liquid 20 includes one of a sample, a reagent, and a mixed liquid containing at least a sample and a reagent.

[0080] As an embodiment, the ultrasonic vibrator 120 is an ultrasonic vibrator rod for at least partially inserting into the target liquid 20 to perform ultrasonic work. The ultrasonic vibrator 120 transmits ultrasonic waves to the target liquid 20 in a contact manner to achieve ultrasonic work on the target liquid 20, which helps to reduce the interference of other external components on the ultrasonic transmission. Of course, in specific applications, the arrangement of the ultrasonic vibrator 120 is not limited to this. For example, as an alternative embodiment, the ultrasonic vibrator 120 is a component that performs ultrasonic work on the target liquid 20 in a non-contact manner.

[0081] As an implementation mode, the ultrasonic vibration rod is a horn. The end surface of the ultrasonic vibration rod at one end away from the ultrasonic transducer 110 is the main output surface of the ultrasonic vibration rod for transmitting ultrasonic waves outward.

[0082] As an embodiment, the ultrasonic vibrator 120 has a positioning portion 121 for calibration and positioning. The driving mechanism 130 can determine the position and movement distance information of the ultrasonic vibrator 120 according to the position information of the positioning portion 121. When the sample analyzer 10 is installed or maintained, the position of the ultrasonic vibrator 120 is mainly adjusted by adjusting the position of the positioning portion 121.

[0083] As an implementation manner, the positioning portion 121 is a rod tip portion of the ultrasonic vibration rod, that is, the end portion of the ultrasonic vibration rod away from the ultrasonic transducer 110 .

[0084] As an implementation manner, the driving mechanism 130 is used to drive the ultrasonic vibrator 120 to move in two-dimensional or three-dimensional space, so that the ultrasonic vibrator 120 moves to different positions.

[0085] As an embodiment, the driving mechanism 130 is a rocker mechanism, which includes a rocker 131, a rotation driving component, and a lifting driving component. The lifting driving component is installed at one end of the rocker 131 and is connected to the ultrasonic transducer 110 and / or the ultrasonic vibrator 120 to drive the ultrasonic vibrator 120 to perform vertical lifting movement. The rotation driving component is connected to the other end of the rocker 131 to drive the rocker 131 to drive the ultrasonic vibrator 120 to swing horizontally along a preset arc trajectory to drive the ultrasonic vibrator 120 to move horizontally. Of course, in specific applications, the setting method of the driving mechanism 130 is not limited to this. For example, as an alternative embodiment, the driving mechanism 130 can also be a guide rail type moving mechanism.

[0086] As an embodiment, the sample analyzer 10 further includes a first solid reference piece 710, and the first solid reference piece 710 is formed with at least one first reference position 711, and the first reference position 711 is arranged corresponding to the first ultrasonic working position 712, and the position information of the first reference position 711 is different from the position information of the first ultrasonic working position 712. The first solid reference piece 710 is a reference piece in a solid state, that is, the first solid reference piece 710 is solid. The first reference position 711 is fixed relative to the first ultrasonic working position 712, so as long as the position information of the first reference position 711 is obtained, the position information of the first ultrasonic working position 712 can be further calculated according to the position relationship of the first reference position 711 relative to the first ultrasonic working position 712. When the ultrasonic device 100 is working, the working parameters of the ultrasonic device 100 will be different when the positioning portion 121 on the ultrasonic vibrator 120 contacts the air and contacts the solid. Therefore, it is possible to determine whether the positioning portion 121 contacts the first solid reference part 710 based on the working parameters of the ultrasonic device 100 during the movement of the ultrasonic vibrator 120, thereby obtaining the position information of the first reference position 711, and then further calculate the position information of the first ultrasonic working position 712 based on the position relationship of the first reference position 711 relative to the first ultrasonic working position 712.

[0087] As an embodiment, when the ultrasonic device 100 moves to the first reference position 711, the working parameters of the ultrasonic device 100 meet the preset conditions. In this way, during the movement of the positioning portion 121 toward the first reference position 711, it can be judged whether the ultrasonic device 100 moves to the first reference position 711 by whether the working parameters of the ultrasonic device 100 meet the preset conditions.

[0088] As an implementation manner, the sample analyzer 10 further includes a control device 200 , and the control device 200 is at least used to control the operation of the ultrasonic device 100 .

[0089] As an embodiment, the control device 200 is configured to: control the driving mechanism 130 to drive the positioning part 121 to move from the first preset position toward the first reference position 711, obtain the working parameters of the ultrasonic device 100 during the movement of the positioning part 121 toward the first reference position 711, and when the working parameters of the ultrasonic device 100 are obtained to meet the preset conditions, the position information of the first ultrasonic working position 712 is obtained based on the distance information of the positioning part 121 moving from the first preset position to the first reference position 711. In this embodiment, the position debugging control scheme of the ultrasonic vibrator 120 is set by utilizing the different working parameters of the ultrasonic vibrator 121 contacting the air and the solid when the ultrasonic device 100 is working, thereby realizing the automatic debugging of the position of the ultrasonic vibrator 120. Since the debugging process can be automatically performed according to the set program, without the need for manual operation by the operator, the operation process of the ultrasonic vibrator 120 position debugging is effectively simplified, and the time and energy occupied by the operator during the debugging process is reduced.

[0090] As an embodiment, the position information of the first ultrasonic working position 712 includes at least one of the following information: the distance information of the positioning unit 121 moving from the first preset position to the first ultrasonic working position 712, and the coordinate information of the first ultrasonic working position 712 in the preset coordinate system. The distance information includes information such as the motion trajectory, the motion direction, and the motion stroke. The coordinate information is three-dimensional coordinate information. In this embodiment, the driving mechanism 130 can be controlled to drive the ultrasonic vibrator 120 to move to the first ultrasonic working position 712 according to the distance information of the first ultrasonic working position 712 relative to the first preset position and / or the coordinate information of the first ultrasonic working position 712.

[0091] As an embodiment, the first preset position is the initial position 104 of the positioning part 121. The initial position 104 of the positioning part 121 is the position of the positioning part 121 when the sample analyzer 10 is just turned on and on standby. In this embodiment, the initial position 104 of the positioning part 121 is used as the first preset position for debugging, which helps to reduce the setting of unnecessary position information and simplify the control program of the sample analyzer 10. Of course, in a specific application, as an alternative embodiment, the setting method of the first preset position is not limited to this. For example, as an alternative embodiment, the first preset position can be not only the initial position 104 of the positioning part 121, but also one of the following positions: a position with determined coordinate information in a preset coordinate system, and a position with determined distance information relative to the initial position 104 of the positioning part 121.

[0092] As an embodiment, the working parameter includes at least one of the phase difference between current and voltage, the amplitude of current, the amplitude of voltage, the amplitude of power, and the amplitude of impedance. Specifically, during the position adjustment process of the ultrasonic vibrator 120, before the positioning part 121 moves to the first reference position 711, the ultrasonic device 100 is unloaded, that is, the load of the ultrasonic device 100 is air; when the positioning part 121 moves to the first reference position 711, the load of the ultrasonic device 100 changes from air to solid, and the working voltage and working current signals returned by the ultrasonic device 100 will change. The phase difference between current and voltage, the amplitude of current, the amplitude of voltage, the amplitude of power, and the amplitude of impedance can all be used to characterize the changes in the working parameters of the ultrasonic device 100 under different load conditions. By recording the distance traveled by the positioning part 121 at this time, the distance of the first reference position 711 relative to the first preset position can be calculated, that is, the position information of the first reference position 711 is obtained, and the position information of the first ultrasonic working position 712 is calculated based on the first reference position 711, that is, the position adjustment of the ultrasonic vibrator 120 is completed.

[0093] As an implementation mode, the working parameter includes the phase difference between the current and the voltage, and the preset condition is that the phase difference between the current and the voltage exceeds the first preset threshold range. When the positioning portion 121 moves from the air to contact the solid, the amplitude of the phase difference between the working current and the working voltage of the ultrasonic device 100 will change significantly. In this implementation mode, it is mainly determined whether the positioning portion 121 moves to the first reference position 711 by identifying the change in the phase difference between the working current and the working voltage of the ultrasonic device 100 during the movement of the ultrasonic vibrator 120. Of course, in specific applications, the setting method of the working parameters and preset conditions is not limited to this. For example, as an alternative implementation scheme, the working parameters include the amplitude of the current, and the preset condition is that the amplitude of the working current of the ultrasonic device 100 is outside the second preset threshold range; or, the working parameters include the amplitude of the voltage, and the preset condition is that the amplitude of the working voltage of the ultrasonic device 100 is outside the third preset threshold range; or, the working parameters include the amplitude of the power, and the preset condition is that the amplitude of the working power of the ultrasonic device 100 is outside the fourth preset threshold range; or, the working parameters include the amplitude of the impedance, and the preset condition is that the amplitude of the impedance of the ultrasonic device 100 is outside the fifth preset threshold range.

[0094] As an implementation mode, at least one first reference position 711 includes at least one first vertical reference position 7111. The above-mentioned obtaining the position information of the first ultrasonic working position 712 based on the distance information of the positioning unit 121 moving from the first preset position to the first reference position 711 includes: obtaining the vertical position information of the first ultrasonic working position 712 based on the distance information of the positioning unit 121 moving from the first preset position to the first vertical reference position 7111. This implementation mode is applicable to the scenario where the first ultrasonic working position 712 is not at the same height as the first preset position, so as to realize the debugging of the vertical position of the first ultrasonic working position 712.

[0095] As an implementation mode, at least one first reference position 711 includes at least one first horizontal reference position 7112; the above-mentioned obtaining the position information of the first ultrasonic working position 712 based on the distance information of the positioning unit 121 moving from the first preset position to the first reference position 711 includes: obtaining the horizontal position information of the first ultrasonic working position 712 based on the distance information of the positioning unit 121 moving from the first preset position to the first horizontal reference position 7112. This implementation mode is applicable to the scenario where the first ultrasonic working position 712 and the first preset position are not at the same horizontal position, so as to realize the debugging of the horizontal position of the first ultrasonic working position 712.

[0096] As an implementation manner, at least one first reference position 711 includes at least one first vertical reference position 7111 and at least one first horizontal reference position 7112. Based on the distance information of the positioning unit 121 moving from the first preset position to the first reference position 711, the position information of the first ultrasonic working position 712 is obtained, including: based on the distance information of the positioning unit 121 moving from the first preset position to the first vertical reference position 7111, the vertical position information of the first ultrasonic working position 712 is obtained; based on the distance information of the positioning unit 121 moving from the first preset position to the first horizontal reference position 7112, the horizontal position information of the first ultrasonic working position 712 is obtained; based on the vertical position information of the first ultrasonic working position 712 and / or the horizontal position information of the first ultrasonic working position 712, the position information of the first ultrasonic working position 712 is obtained. This implementation manner is applicable to the scenario where the first ultrasonic working position 712 and the first preset position are neither at the same height position nor at the same horizontal position, so as to realize the vertical position adjustment and horizontal position adjustment of the first ultrasonic working position 712.

[0097] As an embodiment, at least one first reference position 711 includes at least one first vertical reference position 7111 and at least one first horizontal reference position 7112, and the controller is further configured to: first obtain the vertical position information of the first ultrasonic working position 712, and then obtain the horizontal position information of the first ultrasonic working position 712; before controlling the driving mechanism 130 to drive the positioning part 121 to move toward the first horizontal reference position 7112, the driving mechanism 130 is controlled to drive the positioning part 121 to move to the target position, and at the target position, the vertical distance from the positioning part 121 to the first preset position is greater than the vertical distance from the first vertical reference position 7111 to the first preset position. In the present embodiment, during the debugging of the first ultrasonic working position 712, the vertical position of the first ultrasonic working position 712 is first debugged, and then the positioning portion 121 is moved to a target position lower than the first vertical reference position 7111 according to the vertical position of the first ultrasonic working position 712. This helps to ensure that when the driving mechanism 130 drives the ultrasonic vibrator 120 to move horizontally, the positioning portion 121 can contact the first horizontal reference position 7112.

[0098] As an embodiment, at least one first reference position 711 includes at least two first horizontal reference positions 7112. Based on the distance information of the positioning unit 121 moving from the first preset position to the first horizontal reference position 7112, the horizontal position information of the first ultrasonic working position 712 is obtained, including: based on the distance information of the positioning unit 121 moving from the first preset position to each first horizontal reference position 7112, the horizontal position information of the first ultrasonic working position 712 is obtained. Here, based on the distance information of the positioning unit 121 moving from the first preset position to each first horizontal reference position 7112, it includes one of the following situations: (1) based on the distance information of the positioning unit 121 moving from the first preset position to each first horizontal reference position 7112 in sequence, in which case, the positioning unit 121 moves from the first preset position to the target position, and then moves from the target position to a first horizontal reference position 7112, and then does not return to the first preset position, but directly moves from the first horizontal reference position 7112 to the next first horizontal reference position 7112. (2) Based on the distance information of the positioning unit 121 moving from the first preset position to each first horizontal reference position 7112, in this case, after the positioning unit 121 moves from the first preset position to the target position to a first horizontal reference position 7112, it first returns to the first preset position or the target position, and then moves from the first preset position or the target position to the next first horizontal reference position 7112. In this embodiment, the horizontal position information of the first ultrasonic working position 712 is determined by more than two first horizontal reference positions 7112, which is conducive to ensuring the accuracy and reliability of the horizontal position debugging of the ultrasonic working position, and is conducive to reducing the horizontal position accuracy requirements for the target position. Of course, in specific applications, as an alternative embodiment, the horizontal position debugging of a first ultrasonic working position 712 can also use only one first horizontal reference position 7112.

[0099] As an implementation manner, the first reference position 711 includes two first horizontal reference positions 7112 , and the horizontal position of the first ultrasonic working position 712 is located on a line connecting the two first horizontal reference positions 7112 . The above-mentioned method of obtaining the horizontal position information of the first ultrasonic working position 712 based on the distance information of the positioning part 121 moving from the first preset position to each first horizontal reference position 7112 includes: first controlling the driving mechanism 130 to drive the positioning part 121 to move between the two first horizontal reference positions 7112; then controlling the driving mechanism 130 to drive the positioning part 121 to move toward one first horizontal reference position 7112, and obtaining the working parameters of the ultrasonic device 100 during the movement of the ultrasonic vibrator 120 toward the first horizontal reference position 7112; when it is obtained that the working parameters of the ultrasonic transducer 110 meet the preset conditions, controlling the driving mechanism 130 to drive the positioning part 121 to move toward another first horizontal reference position 7112, and obtaining the working parameters of the ultrasonic device 100 during the movement of the positioning part 121 toward the first horizontal reference position 7112; when it is obtained that the working parameters of the ultrasonic transducer 110 meet the preset conditions, the horizontal position information of the first ultrasonic working position 712 is obtained based on the distance information of the positioning part 121 moving to the two first horizontal reference positions 7112. In this embodiment, the target position is located between the two first horizontal reference positions 7112 and lower than the first vertical reference position 7111. After the control driving mechanism 130 drives the positioning portion 121 to move between the two first horizontal reference positions 7112, the positioning portion 121 is first driven down to the target position, and then moves from the target position to the two first horizontal reference positions 7112 in sequence.

[0100] As an embodiment, the ultrasonic device 100 is used to ultrasonically mix the target liquid 20. The target liquid 20 is one of a sample, a reagent, and a mixed liquid containing at least a sample and a reagent. The ultrasonic device 100 achieves the effect of mixing the target liquid 20 by transmitting ultrasonic waves to the target liquid 20. The use of the ultrasonic device 100 to mix the target liquid 20 has the characteristic of high mixing efficiency, which is conducive to improving the sample measurement efficiency of the sample analyzer 10.

[0101] As an embodiment, the first solid reference member 710 includes a mixing seat, which is formed with a receiving hole for carrying the reaction container 30; the first ultrasonic working position 712 is a first ultrasonic mixing position. The ultrasonic vibrator 120 is used to ultrasonically mix the target liquid 20 in the reaction container 30 at the first ultrasonic working position 712. The control device 200 is also configured to: before controlling the ultrasonic transducer 110 to drive the ultrasonic vibrator 120 to perform an ultrasonic mixing operation, control the driving mechanism 130 to drive the ultrasonic vibrator 120 to move to the first ultrasonic working position 712. During the ultrasonic mixing process, the ultrasonic vibrator 120 is at least partially inserted into the target liquid 20 located at the first ultrasonic working position 712 and in the reaction container 30 to ultrasonically mix the target liquid 20.

[0102] As an embodiment, the first reference position 711 includes a first vertical reference position 7111 and two first horizontal reference positions 7112; the first vertical reference position 7111 is located on the top surface of the mixing seat; the two first horizontal reference positions 7112 are both located on the inner side wall of the receiving hole, and the two first horizontal reference positions 7112 are located on the same diameter of the receiving hole. In this embodiment, the mixing seat is used as the first solid reference part 710, and the first vertical reference position 7111 and the first horizontal reference position 7112 are both located on the mixing seat. In this way, the inherent structure of the sample analyzer 10 can be used to adjust the position of the ultrasonic vibrator 120 without adding additional components. Of course, in specific applications, as an alternative embodiment, the setting method of the first solid reference part 710 is not limited to this. For example, other fixed components can be added to the mixing seat as the first solid reference component, or, in the case of reinforcing the reaction container 30, the reaction container 30 can also be used as the first solid reference part 710.

[0103] As an embodiment, the driving mechanism 130 is also used to drive the ultrasonic vibrator 120 to move to the second ultrasonic working position 1053 for operation, and the position information of the second ultrasonic working position 1053 is different from the position information of the first ultrasonic working position 712. The sample analyzer 10 also includes a second solid reference member 105, and the second solid reference member 105 is formed with at least one second reference position 1051, and the position information of the second reference position 1051 is different from the position information of the second ultrasonic working position 1053. The controller is also configured to: control the driving mechanism 130 to drive the positioning part 121 to move from the second preset position toward the second reference position 1051, and obtain the working parameters of the ultrasonic device 100 during the movement of the positioning part 121 toward the second reference position 1051, and when the working parameters of the ultrasonic device 100 obtained meet the preset conditions, the position information of the second ultrasonic working position 1053 is obtained based on the distance information of the positioning part 121 moving from the first preset position to the second reference position 1051. The sample analyzer 10 of the present embodiment has at least two ultrasonic working positions, each of which corresponds to at least one reference position. The debugging of each ultrasonic working position is based on the different working parameters of the positioning part 121 on the ultrasonic vibrator 120 contacting the air and contacting the solid ultrasonic device 100. First, the distance information of the positioning part 121 reaching the reference position is obtained, and then the position information of the corresponding ultrasonic working position is obtained based on the distance information of the reference position.

[0104] As an implementation mode, the position information of the second preset position is the same as the position information of the first preset position, that is, the second preset position and the first preset position are the same position. Of course, in a specific application, as an alternative implementation mode, the position information of the second preset position may also be different from the position information of the first preset position, that is, the second preset position and the first preset position may be two different positions.

[0105] As an embodiment, the second solid reference member 105 includes a cleaning pool, and the second ultrasonic working position 1053 is a cleaning position of the ultrasonic vibrator 120. The cleaning pool is used to contain a cleaning liquid to clean the ultrasonic vibrator 120 located at the second ultrasonic working position 1053. After performing ultrasonic mixing of a mixed liquid, the ultrasonic vibrator 120 should first move to the cleaning position for cleaning, and then perform ultrasonic mixing of the next mixed liquid, so as to avoid cross contamination and further ensure the accuracy of the sample measurement results.

[0106] As an embodiment, the second preset position is the initial position 104 of the positioning part 121; the initial position 104 is located directly above the second ultrasonic working position 1053; the second reference position 1051 includes a second vertical reference position 1052 formed on the top surface of the cleaning tank. The above-mentioned obtaining the position information of the second ultrasonic working position 1053 based on the distance information of the positioning part 121 moving from the second preset position to the second reference position 1051 includes: obtaining the position information of the second ultrasonic working position 1053 based on the distance information of the positioning part 121 moving from the second preset position to the second vertical reference position 1052. In this embodiment, the initial position 104 of the positioning part 121 is set directly above the second ultrasonic working position 1053, so that the position adjustment of the second ultrasonic working position 1053 only requires adjusting the vertical position of the second ultrasonic working position 1053, thereby simplifying the control system of the movement of the ultrasonic device 100.

[0107] In the above-mentioned implementation scheme, the sample analyzer 10 has two ultrasonic working positions, namely, a first ultrasonic mixing position and a cleaning position, which can meet the ultrasonic mixing requirements of the mixed liquid and the cleaning requirements of the ultrasonic vibrator 120 after ultrasonic mixing. In specific applications, the sample analyzer 10 can also be provided with other ultrasonic working positions, such as a reagent mixing position. Specifically, in this alternative implementation scheme, the driving mechanism 130 is also used to drive the ultrasonic vibrator 120 to move to a third ultrasonic working position for operation, and the position information of the third ultrasonic working position is different from the position information of the first ultrasonic working position 712; the sample analyzer 10 also includes a third solid reference member, and the third solid reference member is formed with at least one third reference position, and the third reference position is set corresponding to the third ultrasonic working position, and the position information of the third reference position is different from the position information of the third ultrasonic working position; the controller is also configured to: control the driving mechanism 130 to drive the positioning portion 121 from the third preset position toward the third Reference position movement, the working parameters of the ultrasonic device 100 are obtained during the movement of the positioning part 121 toward the third reference position. When the working parameters of the ultrasonic device 100 obtained meet the preset conditions, the position information of the third ultrasonic working position is obtained based on the distance information of the positioning part 121 moving from the first preset position to the third reference position; the third solid reference part includes a reagent loading device 600, the reagent loading device 600 is formed with a receiving groove for receiving the reagent container, the third ultrasonic working position is the second ultrasonic mixing position, and the ultrasonic vibrator 120 is used to ultrasonically mix the reagent in the reagent container at the third ultrasonic working position; wherein the position information of the third preset position is the same as or different from the position information of the first preset position. The third ultrasonic working position can be specifically used for the ultrasonic vibrator 120 to ultrasonically mix the magnetic bead reagent in the reagent loading device 600. The position debugging method of the third ultrasonic working position can refer to the position debugging method of the first ultrasonic working position, which will not be described in detail here.

[0108] As an embodiment, the sample analyzer 10 further includes a sample dispensing device 300, which is used to dispense at least part of the sample in the sample container to the reaction container 30. Specifically, the sample dispensing device 300 is used to draw a sample from the sample container and distribute at least part of the drawn sample to the reaction container 30. The sample container is used to load a sample collected from a patient. The reaction container 30 is used to carry the sample for reaction and / or determination. The sample dispensing device 300 is mainly used to achieve quantitative distribution of the sample.

[0109] As an implementation manner, the sample distributing device 300 is used to draw samples from a sample container located at a sample aspirating position and distribute them to a reaction container 30 located at a sample adding position.

[0110] As an embodiment, the sample dispensing device 300 includes a sample needle, a first motion driving device and a first suction and discharge driving device, wherein the first motion driving device is used to drive the sample needle to move in two-dimensional or three-dimensional space so as to move the sample needle to different positions, such as a standby position, a sample suction position, a sample addition position, a cleaning position, etc. The first suction and discharge driving device is used to drive the sample needle to perform suction and discharge actions.

[0111] As an embodiment, the sample analyzer 10 further includes a reagent dispensing device 400, which is used to dispense at least part of the reagent in the reagent container to the reaction container 30. Specifically, the reagent dispensing device 400 is used to draw reagents from the reagent container and distribute at least part of the drawn reagents to the reaction container 30. The reagent container is used to store the reagents required for the assay. The reagent dispensing device 400 is mainly used to achieve quantitative distribution of the reagents.

[0112] As an embodiment, the reagent dispensing device 400 includes a reagent needle, a second motion drive device and a second suction and discharge drive device, and the second motion drive device is used to drive the reagent needle to move in two-dimensional or three-dimensional space, so that the reagent needle moves to different workstations, such as a standby position, a reagent suction position, a reagent addition position, a cleaning position, etc. The second suction and discharge drive device is used to drive the reagent needle to perform suction and discharge actions. It should be noted that the reagent dispensing device 400 may include multiple reagent needles, multiple groups of second motion drive devices and multiple groups of second suction and discharge drive devices, and any two reagent needles can be used to absorb and dispense different types of reagents, respectively, or can be used to absorb and dispense the same type of reagent at different times.

[0113] As an embodiment, the sample analyzer 10 further includes a reagent loading device 600 for storing reagent containers. The reagent dispensing device 400 is used to absorb reagents from the reagent containers on the reagent loading device 600 and distribute at least part of the absorbed reagents into the reaction container 30.

[0114] As an implementation manner, the reagent loading device 600 is in the shape of a disk, and a plurality of reagent positions are formed thereon, and a plurality of reagent containers can be stored simultaneously.

[0115] As an embodiment, the sample analyzer 10 further includes a measuring device 500, and the measuring device 500 is used to perform sample measurement on the reaction solution made of at least a mixture of the sample and the reagent in the reaction container 30. The measuring device 500 may be an optical measuring device 500.

[0116] As an embodiment, the sample analyzer 10 further includes an incubation device 700 and a transfer device 800. The incubation device 700 is used to incubate the liquid in the reaction container 30. The transfer device 800 is used to transfer the reaction container 30, for example, to transfer the reaction container 30 after sample addition to the incubation device 700. The reagent dispensing device 400 is used to dispense the reagent into the reaction container 30 located on the incubation device 700. The measuring device 500 is arranged beside the incubation device 700, so as to perform optical measurement on the reaction liquid in the reaction container 30 on the incubation device 700.

[0117] As an embodiment, the incubation device 700 is disc-shaped and has a plurality of incubation holes formed thereon, so that a plurality of reaction containers 30 can be incubated simultaneously.

[0118] As an embodiment, the incubation device 700 is a disc-shaped structure that can drive the reaction container 30 to rotate.

[0119] As an embodiment, the ultrasonic mixing position is located on the incubation device 700. The above-mentioned mixing seat (first reference fixture 710) is a part of the incubation device 700. The ultrasonic device 100 is used to ultrasonically mix the target liquid 20 in the reaction container 30 on the incubation device 700. Of course, in a specific application, as an alternative embodiment, the ultrasonic mixing position (first ultrasonic working position 712) may not be located on the incubation device 700, that is, the mixing seat may be a component independent of the incubation device 700.

[0120] As an embodiment, the transfer device 800 includes at least one clamping component and at least one third motion driving device for driving the clamping component to move.

[0121] As an embodiment, the sample analyzer 10 also includes a reaction container providing device 900 and a reaction container recovery device, the reaction container providing device 900 is used to provide a reaction container 30, and the reaction container recovery device is used to recover the reaction container 30. The sample analyzer 10 also forms a recovery position, and the reaction container recovery device is located below the recovery position. The transfer device 800 is also used to transfer the reaction container 30 from the incubation device 700 to the recovery position for release and recovery. In this embodiment, the reaction container 30 is a disposable container, that is, a reaction container 30 is recycled after completing a measurement project. Of course, in specific applications, the reaction container 30 can also be a recycled container, that is, the reaction container 30 completes a measurement project, can be cleaned in the sample analyzer 10 and then reused for other measurement projects.

[0122] As an embodiment, the sample analyzer 10 also includes a sample management device 101 and a sample transport device 102. The sample management device 101 is used to place a sample container loaded with a sample to achieve sample loading and storage. The sample transport device 102 is used to transport the sample container output by the sample management device 101 to the sample suction position.

[0123] As an embodiment, the control device 200 includes an ultrasonic control board 210 and a main control board 220. The ultrasonic control board 210 is used to control the operation of the ultrasonic device 100, and the main control board 220 is used to control at least the operation of the ultrasonic control board 210, the sample dispensing device 300, the reagent dispensing device 400, and the measuring device 500. In this embodiment, the ultrasonic control board 210 and the main control board 220 are two independent circuit boards. Of course, in a specific application, as an alternative embodiment, the ultrasonic control board 210 and the main control board 220 can also be integrated into one circuit board.

[0124] As an embodiment, the main control board 220 is also used to control the operation of the incubation device 700 , the transfer device 800 , the magnetic separation device 103 , the reaction container providing device 900 , the sample management device 101 and the sample transport device 102 .

[0125] As an embodiment, the sample is a blood sample, the sample analyzer 10 is an immunoanalyzer, and the sample analyzer 10 also includes a magnetic separation device 103, which is used to magnetically separate the liquid in the reaction container 30. The liquid treated by the magnetic separation device 103 includes a clear liquid and a magnetic bead liquid, the clear liquid is treated as a waste liquid, and the magnetic bead liquid is used to prepare a subsequent reaction liquid. The measurement process of a measurement item in the immunoanalyzer includes: adding a sample, adding a reagent to form a first mixed liquid, mixing and incubating the first mixed liquid to obtain a second mixed liquid, magnetically separating the second mixed liquid to obtain a liquid after magnetic separation, adding a substrate to the liquid after magnetic separation to obtain a third mixed liquid, mixing and incubating the third mixed liquid to obtain a reaction liquid, and optically measuring the reaction liquid. During the magnetic separation process, the operation of adding a separation liquid and mixing will be performed. The above-mentioned mixed liquid as the target liquid 20 includes at least one of the following situations: a first mixed liquid after adding a sample and a reagent and before incubation, a second mixed liquid during the magnetic separation process, and a third mixed liquid formed after the magnetic separation and the addition of a substrate and before incubation. Of course, in a specific application, the type of the sample analyzer 10 is not limited thereto. For example, as an alternative embodiment, the sample analyzer 10 may also be a biochemical analyzer, a blood routine cell analyzer, or a coagulation analyzer.

[0126] The present embodiment also provides a method for adjusting the position of an ultrasonic vibrator 120 in a sample analyzer 10, the method comprising the following steps: controlling the driving mechanism 130 of the ultrasonic device 100 to drive the positioning portion 121 of the ultrasonic vibrator 120 to move from a first preset position toward a first reference position 711 of a first solid reference member 710; acquiring working parameters of the ultrasonic device 100 during the movement of the positioning portion 121 toward the first reference position 711; when the working parameters of the ultrasonic device 100 obtained meet preset conditions, based on the distance information of the positioning portion 121 moving from the first preset position to the first reference position 711, obtaining the position information of the first ultrasonic working position 712; wherein the position information of the first ultrasonic working position 712 comprises at least one of the following information: the distance information of the positioning portion 121 moving from the first preset position to the first ultrasonic working position 712, and the coordinate information of the first ultrasonic working position 712 in a preset coordinate system.

[0127] As an implementation manner, the first preset position includes one of the following positions: the initial position 104 of the positioning unit 121 , a position having determined coordinate information in a preset coordinate system, and a position having determined distance information relative to the initial position 104 .

[0128] As an implementation manner, the operating parameter includes at least one of a phase difference between current and voltage, an amplitude of current, an amplitude of voltage, an amplitude of power, and an amplitude of impedance.

[0129] As an implementation manner, at least one first reference position 711 includes at least one first vertical reference position 7111 and / or at least one first horizontal reference position 7112. Based on the distance information of the positioning unit 121 moving from the first preset position to the first reference position 711, the position information of the first ultrasonic working position 712 is obtained, including: based on the distance information of the positioning unit 121 moving from the first preset position to the first vertical reference position 7111, the vertical position information of the first ultrasonic working position 712 is obtained; and / or based on the distance information of the positioning unit 121 moving from the first preset position to the first horizontal reference position 7112, the horizontal position information of the first ultrasonic working position 712 is obtained; based on the vertical position information of the first ultrasonic working position 712 and / or the horizontal position information of the first ultrasonic working position 712, the position information of the first ultrasonic working position 712 is obtained.

[0130] As an embodiment, at least one first reference position 711 includes at least two first horizontal reference positions 7112; based on the distance information of the positioning unit 121 moving from the first preset position to the first horizontal reference position 7112, the horizontal position information of the first ultrasonic working position 712 is obtained, including: based on the distance information of the positioning unit 121 moving from the first preset position to each first horizontal reference position 7112, the horizontal position information of the first ultrasonic working position 712 is obtained.

[0131] As an embodiment, the first solid reference piece 710 includes a mixing seat, which is formed with a receiving hole for supporting the reaction container 30. The ultrasonic vibrator 120 is used to ultrasonically mix the target liquid 20 in the reaction container 30 at the first ultrasonic working position 712. The target liquid 20 is one of a sample, a reagent, and a mixed liquid containing at least a sample and a reagent.

[0132] As an embodiment, the position debugging method of the ultrasonic vibrator 120 also includes the following steps: controlling the driving mechanism 130 to drive the positioning part 121 to move from the first preset position toward the second reference position 1051 of the second fixed reference part, and obtaining the working parameters of the ultrasonic device 100 during the movement of the positioning part 121 toward the second reference position 1051. When the working parameters of the ultrasonic device 100 obtained meet the preset conditions, the position information of the second ultrasonic working position 1053 is obtained based on the distance information of the positioning part 121 moving from the second preset position to the second reference position 1051, wherein the second solid reference part 105 includes a cleaning tank, which is used to contain cleaning liquid to clean the ultrasonic vibrator 120 located at the second ultrasonic working position 1053, and the position information of the second preset position is the same as or different from the position information of the first preset position.

[0133] The specific principles and implementations of the control method provided in this embodiment are similar to those described in the above-mentioned sample analyzer 10 and will not be described in detail here.

[0134] This embodiment also provides a computer-readable storage medium, which stores a computer program. When the computer program is executed by a processor (such as the processor in the control device 200 described above), the processor implements the steps of the position adjustment method of the ultrasonic vibrator 120 in the sample analyzer 10 described above. The computer-readable storage medium may be an internal storage unit of the sample analyzer 10 described above, such as a hard disk or memory of the sample analyzer 10; or, the computer-readable storage medium may also be an external storage device of the sample analyzer 10, such as a plug-in hard disk, a smart memory card (Smart Media Card, SMC), a secure digital (Secure Digital, SD) card, a flash card (Flash Card), etc. equipped on the sample analyzer 10.

[0135] In the above scheme, the ultrasonic device 100 is used to transmit ultrasonic waves to the target liquid 20 to achieve ultrasonic mixing. Of course, in specific applications, the position adjustment principle of the ultrasonic vibrator 120 can also be used in ultrasonic cleaning. Specifically, when the ultrasonic device 100 is used for ultrasonic cleaning, the target liquid 20 is a cleaning liquid, and the cleaning liquid is used to clean the parts to be cleaned. The parts to be cleaned are one of the sample needle, the reagent needle, the reaction container 30, and the stirring rod.

[0136] In this embodiment, the adjustment of the position of the ultrasonic vibrator 120 is divided into horizontal position adjustment and vertical position adjustment. The basic method and process rely on the instantaneous signal change when the ultrasonic vibrator 120 contacts the solid to identify the solid position. The following takes the vertical position debugging of an ultrasonic working position of the ultrasonic vibrator 120 as an example to illustrate its debugging method and process: when the position of the ultrasonic vibration rod tip relative to the ultrasonic working position (a certain position in the reaction container 30) is unknown, the ultrasonic vibrator 120 is driven at a low speed to start horizontal and vertical movement from the starting point (i.e., the initial position 104 of the positioning part 121, which can also be used as the coordinate origin), and the ultrasonic transducer 110 is turned on at a low power. At this time, the load of the ultrasonic device 100 is air, and the ultrasonic device 100 will return the voltage and current at this time. When the tip of the ultrasonic vibration rod touches the solid reference position, the load changes from air to solid, and the working voltage and working current signals returned by the ultrasonic device 100 will change significantly. By recording the distance traveled by the driving mechanism 130 driving the ultrasonic vibrator 120 at this time, the distance of this reference position relative to the starting point of the movement (the coordinate origin) can be calculated, and then the coordinates of the ultrasonic working position are obtained based on the relationship between the reference position and the ultrasonic working position, that is, the vertical position debugging of the ultrasonic working position is completed.

[0137] The above description is only a preferred embodiment of the present invention, and does not limit the patent scope of the present invention. All equivalent structural changes made by using the contents of the present invention specification and drawings under the inventive concept of the present invention, or directly / indirectly applied in other related technical fields are included in the patent protection scope of the present invention.

Claims

1. A sample analyzer, characterized in that: include: a sample dispensing device, the sample dispensing device being used to dispense at least a portion of the sample in the sample container to a reaction container; a reagent dispensing device, the reagent dispensing device being used to dispense at least part of the reagent in the reagent container into the reaction container; a measuring device for performing a sample measurement on a reaction solution made of at least a mixture of a sample and a reagent in the reaction container; An ultrasonic device, comprising an ultrasonic transducer, an ultrasonic vibrator and a driving mechanism, wherein the ultrasonic vibrator is connected to the ultrasonic transducer to generate ultrasonic vibration under the drive of the ultrasonic transducer, the driving mechanism is connected to the ultrasonic transducer and / or the ultrasonic vibrator to at least drive the ultrasonic vibrator to move to a first ultrasonic working position to perform ultrasonic work, and the ultrasonic vibrator has a positioning portion for calibration and positioning; a first solid reference piece, wherein the first solid reference piece forms at least one first reference position, and position information of the first reference position is different from position information of the first ultrasonic working position, and when the ultrasonic device moves to the first reference position, the working parameters of the ultrasonic device meet a preset condition; a control device, the control device being configured to: control the driving mechanism to drive the positioning part to move from a first preset position toward the first reference position, obtain working parameters of the ultrasonic device during the movement of the positioning part toward the first reference position, and when the working parameters of the ultrasonic device obtained meet preset conditions, obtain position information of the first ultrasonic working position based on distance information of the positioning part moving from the first preset position to the first reference position; The position information of the first ultrasonic working position includes at least one of the following information: distance information of the positioning unit moving from the first preset position to the first ultrasonic working position, and coordinate information of the first ultrasonic working position in a preset coordinate system.

2. The sample analyzer according to claim 1, wherein: The first preset position includes one of the following positions: an initial position of the positioning unit, a position having determined coordinate information in a preset coordinate system, and a position having determined distance information relative to the initial position of the positioning unit.

3. The sample analyzer according to claim 1, wherein: The operating parameter includes at least one of a phase difference between current and voltage, an amplitude of current, an amplitude of voltage, an amplitude of power, and an amplitude of impedance.

4. The sample analyzer according to claim 1, wherein: The at least one first reference position comprises at least one first vertical reference position and / or at least one first horizontal reference position; The obtaining the position information of the first ultrasonic working position based on the distance information of the positioning part moving from the first preset position to the first reference position includes: Based on the distance information of the positioning unit moving from the first preset position to the first vertical reference position, the vertical position information of the first ultrasonic working position is obtained; and / or based on the distance information of the positioning unit moving from the first preset position to the first horizontal reference position, the horizontal position information of the first ultrasonic working position is obtained; The position information of the first ultrasonic working position is obtained based on the vertical position information of the first ultrasonic working position and / or the horizontal position information of the first ultrasonic working position.

5. The sample analyzer according to claim 4, characterized in that: said at least one first reference position comprises at least two of said first horizontal reference positions; The method of obtaining the horizontal position information of the first ultrasonic working position based on the distance information of the positioning part moving from the first preset position to the first horizontal reference position includes: obtaining the horizontal position information of the first ultrasonic working position based on the distance information of the positioning part moving from the first preset position to each of the first horizontal reference positions.

6. The sample analyzer according to claim 5, characterized in that: The first reference position includes two first horizontal reference positions, and the horizontal position of the first ultrasonic working position is located on a line connecting the two first horizontal reference positions; The obtaining the horizontal position information of the first ultrasonic working position based on the distance information of the positioning unit moving from the first preset position to each of the first horizontal reference positions includes: First, controlling the driving mechanism to drive the positioning portion to move between the two first horizontal reference positions; Then controlling the driving mechanism to drive the positioning portion to move toward the first horizontal reference position, and obtaining the working parameters of the ultrasonic device during the movement of the ultrasonic vibrator toward the first horizontal reference position; When the working parameters of the ultrasonic transducer are obtained to meet preset conditions, the driving mechanism is controlled to drive the positioning part to move toward another first horizontal reference position, and the working parameters of the ultrasonic device are obtained during the movement of the positioning part toward the first horizontal reference position. When the working parameters of the ultrasonic device are obtained to meet the preset conditions, the horizontal position information of the first ultrasonic working position is obtained based on the distance information of the positioning part moving to the two first horizontal reference positions.

7. The sample analyzer according to claim 4, characterized in that: The at least one first reference position includes at least one first vertical reference position and at least one first horizontal reference position, and the controller is further configured to: first obtain vertical position information of the first ultrasonic working position, and then obtain horizontal position information of the first ultrasonic working position; Before controlling the driving mechanism to drive the positioning portion to move toward the first horizontal reference position, controlling the driving mechanism to drive the positioning portion to move to a target position, at which the vertical distance from the positioning portion to the first preset position is greater than the vertical distance from the first vertical reference position to the first preset position.

8. The sample analyzer according to any one of claims 1 to 7, characterized in that: The first solid reference member comprises a mixing seat, wherein the mixing seat is formed with a receiving hole for carrying the reaction container; The ultrasonic vibrator is used to ultrasonically mix the target liquid in the reaction container at the first ultrasonic working position, and the target liquid is one of a sample, a reagent, and a mixed liquid containing at least the sample and the reagent.

9. The sample analyzer according to claim 8, wherein: The first reference position includes a first vertical reference position and two first horizontal reference positions; The first vertical reference position is located on the top surface of the mixing seat; The two first horizontal reference positions are both located on the inner side wall of the accommodating hole, and the two first horizontal reference positions are located on the same diameter of the accommodating hole.

10. The sample analyzer according to any one of claims 1 to 7, characterized in that: The driving mechanism is also used to drive the ultrasonic vibrator to move to a second ultrasonic working position for operation, and the position information of the second ultrasonic working position is different from the position information of the first ultrasonic working position; The sample analyzer further includes a second solid reference member, the second solid reference member is formed with at least one second reference position, and position information of the second reference position is different from position information of the second ultrasonic working position; The controller is further configured to: control the driving mechanism to drive the positioning part to move from the second preset position toward the second reference position, obtain the working parameters of the ultrasonic device during the movement of the positioning part toward the second reference position, and when the working parameters of the ultrasonic device obtained meet the preset conditions, obtain the position information of the second ultrasonic working position based on the distance information of the positioning part moving from the first preset position to the second reference position; Wherein, the second solid reference member comprises a cleaning pool, and the cleaning pool is used to contain a cleaning liquid to clean the ultrasonic vibrating member located at the second ultrasonic working position; The location information of the second preset location is the same as or different from the location information of the first preset location.

11. The sample analyzer according to claim 10, characterized in that: The second preset position is the initial position of the positioning portion; The initial position is located directly above the second ultrasonic working position; The second reference position includes a second vertical reference position formed on the top surface of the cleaning tank; The obtaining the position information of the second ultrasonic working position based on the distance information of the positioning part moving from the second preset position to the second reference position includes: obtaining the position information of the second ultrasonic working position based on the distance information of the positioning part moving from the second preset position to the second vertical reference position.

12. The sample analyzer according to any one of claims 1 to 7, characterized in that: The driving mechanism is also used to drive the ultrasonic vibrator to move to the third ultrasonic working position for operation, and the position information of the third ultrasonic working position is different from the position information of the first ultrasonic working position; The sample analyzer further includes a third solid reference piece, the third solid reference piece is formed with at least one third reference position, the third reference position is arranged corresponding to the third ultrasonic working position, and the position information of the third reference position is different from the position information of the third ultrasonic working position; The controller is further configured to: control the driving mechanism to drive the positioning part to move from a third preset position toward the third reference position, obtain working parameters of the ultrasonic device during the movement of the positioning part toward the third reference position, and when the working parameters of the ultrasonic device obtained meet preset conditions, obtain position information of the third ultrasonic working position based on distance information of the positioning part moving from the first preset position to the third reference position; The third solid reference piece includes a reagent loading device, the reagent loading device is formed with a receiving groove for receiving the reagent container, and the ultrasonic vibrator is used to ultrasonically mix the reagent in the reagent container at the third ultrasonic working position; The location information of the third preset location is the same as or different from the location information of the first preset location.

13. A method for adjusting the position of an ultrasonic vibrator in a sample analyzer, characterized in that: The steps include: Controlling the driving mechanism of the ultrasonic device to drive the positioning portion of the ultrasonic vibrator to move from a first preset position toward a first reference position of the first solid reference member; acquiring working parameters of the ultrasonic device during the process of the positioning portion moving toward the first reference position; When it is obtained that the working parameters of the ultrasonic device meet the preset conditions, the position information of the first ultrasonic working position is obtained based on the distance information of the positioning part moving from the first preset position to the first reference position; The position information of the first ultrasonic working position includes at least one of the following information: distance information of the positioning unit moving from the first preset position to the first ultrasonic working position, and coordinate information of the first ultrasonic working position in a preset coordinate system.

14. The method for adjusting the position of an ultrasonic vibrator in a sample analyzer according to claim 13, wherein: The first preset position includes one of the following positions: an initial position of the positioning unit, a position having determined coordinate information in a preset coordinate system, a position having determined distance information relative to the initial position; and / or, The operating parameter includes at least one of a phase difference between current and voltage, an amplitude of current, an amplitude of voltage, an amplitude of power, and an amplitude of impedance.

15. The method for adjusting the position of an ultrasonic vibrator in a sample analyzer according to claim 13, wherein: The at least one first reference position comprises at least one first vertical reference position and / or at least one first horizontal reference position; The obtaining the position information of the first ultrasonic working position based on the distance information of the positioning part moving from the first preset position to the first reference position includes: Based on the distance information of the positioning unit moving from the first preset position to the first vertical reference position, the vertical position information of the first ultrasonic working position is obtained; and / or based on the distance information of the positioning unit moving from the first preset position to the first horizontal reference position, the horizontal position information of the first ultrasonic working position is obtained; The position information of the first ultrasonic working position is obtained based on the vertical position information of the first ultrasonic working position and / or the horizontal position information of the first ultrasonic working position.

16. The method for adjusting the position of an ultrasonic vibrator in a sample analyzer according to claim 15, wherein: said at least one first reference position comprises at least two of said first horizontal reference positions; The method of obtaining the horizontal position information of the first ultrasonic working position based on the distance information of the positioning part moving from the first preset position to the first horizontal reference position includes: obtaining the horizontal position information of the first ultrasonic working position based on the distance information of the positioning part moving from the first preset position to each of the first horizontal reference positions.

17. The method for adjusting the position of an ultrasonic vibrator in a sample analyzer according to any one of claims 13 to 16, characterized in that: The first solid reference piece includes a mixing seat, the mixing seat is formed with a receiving hole for carrying the reaction container, the ultrasonic vibrator is used to ultrasonically mix the target liquid in the reaction container at the first ultrasonic working position, and the target liquid is one of a sample, a reagent, and a mixed liquid containing at least the sample and the reagent; and / or, The position debugging method of the ultrasonic vibrator also includes the following steps: controlling the driving mechanism to drive the positioning part to move from the first preset position toward the second reference position of the second fixed reference part, obtaining the working parameters of the ultrasonic device during the movement of the positioning part toward the second reference position, and when the obtained working parameters of the ultrasonic device meet the preset conditions, based on the distance information of the positioning part moving from the second preset position to the second reference position, obtaining the position information of the second ultrasonic working position, wherein the second solid reference part includes a cleaning tank, and the cleaning tank is used to contain cleaning liquid to clean the ultrasonic vibrator located at the second ultrasonic working position, and the position information of the second preset position is the same as or different from the position information of the first preset position.

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