Whitening essence lotion and preparation method thereof

Abstract

The invention relates to the technical field of whitening lotion, and particularly discloses whitening essence lotion and a preparation method thereof.The whitening essence lotion is prepared from, by mass, 67.6% of deionized water, 1% of glycerin, 0.2% of carbomer, 0.2% of xanthan gum, 7% of 1-3 butanediol, 2% of D-panthenol, 2% of polysorbate-60, 0.2% of ethylhexylglycerin, 17.8% of olive oil and 2% of traditional Chinese medicine extract; the traditional Chinese medicine extract is a mixed extracting solution of radix paeoniae alba, rhizoma atractylodis macrocephalae, white poria cocos and liquorice, and the ratio of the radix paeoniae alba to the rhizoma atractylodis macrocephalae to the white poria cocos to the liquorice is 2: 2: 2: 1. According to the whitening essence lotion, the theory of traditional Chinese medicine is used as a foundation stone, natural Chinese herbal medicines such as the radix paeoniae alba, the rhizoma atractylodis macrocephalae, the white poria cocos and the liquorice are selected as raw materials, active ingredients of the raw materials are extracted, and melanin generation can be effectively inhibited; the traditional Chinese medicine composition has the effects of whitening skin, fading spots and brightening skin color, realizes natural and healthy whitening effects, can provide lasting moisturizing and nourishing for skin, effectively improves the dry state of the skin, and enhances the elasticity and luster of the skin.

Description

Technical Field

[0001] The invention belongs to the technical field of whitening lotions, and in particular relates to a whitening essence lotion and a preparation method thereof. Background Art

[0002] With the continuous progress of society and the improvement of people's living standards, people's pursuit of beauty is no longer limited to external appearance, but has turned more to internal health and external skin care. Whitening essence is a skin care product specially designed to improve skin color, brighten skin tone and reduce spots. In the classification of cosmetics, essence generally refers to products with a higher concentration of active ingredients. During use, it can enhance the special purpose of care due to the high proportion of effective ingredients, so that the skin can achieve a more obvious skin care effect.

[0003] However, although there are a wide variety of whitening products on the market, there are some common problems that cannot be ignored. On the one hand, in order to achieve rapid whitening effects, many products rely too much on artificially synthesized chemical whitening ingredients, such as hydroquinone and vitamin C derivatives. Although these ingredients can inhibit melanin production to a certain extent, long-term use may cause adverse reactions such as skin irritation and allergies, and even damage the skin barrier. On the other hand, some whitening products have poor stability and are easily affected by environmental factors and deteriorate, affecting the effect and safety of use. In addition, insufficient consideration of individual differences and skin tolerance also makes it difficult for some consumers to choose when using whitening products. Summary of the invention

[0004] The object of the present invention is to provide a whitening essence lotion and a preparation method thereof, so as to solve the problems raised in the above background technology.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] A whitening essence lotion and a preparation method thereof. The essence lotion comprises the following raw materials in percentage by mass: 67.6% of deionized water, 1% of glycerol, 0.2% of carbomer, 0.2% of xanthan gum, 7% of 1-3 butylene glycol, 2% of D-panthenol, 2% of polysorbate-60, 0.2% of ethylhexylglycerol, 17.8% of olive oil and 2% of traditional Chinese medicine extract; the traditional Chinese medicine extract is a mixed extract of white peony root, atractylodes macrocephala, white poria cocos and liquorice, and the ratio of the white peony root, atractylodes macrocephala, white poria cocos and liquorice is 2:2:2:1.

[0007] A preparation method of a whitening essence milk comprises the following steps:

[0008] S1. Preparation of Chinese herbal medicine extracts: 500 g each of white peony root, white atractylodes, white poria and licorice were weighed using an electronic scale, crushed using a grinder, passed through a 40-mesh sieve, and white peony root, white atractylodes, white poria and licorice were mixed evenly in a ratio of 2:2:2:1;

[0009] Weigh 14g of mixed medicinal powder and place it in a stoppered conical flask, add 56mL of 50% ethanol, and extract by ultrasonic at 40℃ for 30min. After filtering, take the supernatant as the Chinese medicine extract;

[0010] S2, mixing: glycerin, carbomer, xanthan gum, 1-3 butylene glycol and D-panthenol are added to deionized water, heated to 90°C, maintained for 15 min for sterilization, and cooled to 80°C for emulsification, wherein xanthan gum and carbomer are thickeners, which are added slowly to prevent agglomeration;

[0011] S3, mixing olive oil and polysorbate 60 evenly, heating to 80°C to dissolve, then adding ethylhexylglycerol to dissolve, and stirring continuously to obtain a mixed solution, and then adding it to the solution in S2 to mix evenly;

[0012] S4. Finally, slowly add the Chinese medicine extract in S1 to the mixed solution in S3, put it into a warm water bath oscillator, oscillate for 30 min at 37°C and 120 r / min, and then take it out to obtain a whitening essence lotion.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] The whitening essence milk of the present invention is based on the theory of traditional Chinese medicine, and selects natural Chinese herbal medicines such as white peony root, white atractylodes, white poria, and liquorice as raw materials to extract their active ingredients, which can effectively inhibit the production of melanin, fade spots, brighten the skin tone, and achieve a natural and healthy whitening effect. At the same time, its formula can provide lasting moisture and nourishment for the skin, effectively improve the dry state of the skin, and enhance the elasticity and luster of the skin. It is non-irritating to the skin and has excellent mildness. It can be used safely even for people who are prone to allergies, greatly reducing the risk of allergies and redness caused by traditional whitening products.

[0015] The principle of not adding chemical whitening ingredients avoids the potential safety hazards caused by artificial synthetic ingredients, ensuring the safety of the product. At the same time, it has moisturizing and spreadability, can be quickly absorbed by the skin without leaving a sticky feeling, and avoids the possibility that fragrance ingredients may become potential allergens for some people who are prone to allergies, ensuring the wide applicability and safety of the product. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 is the measurement result of the pH value of the whitening essence milk of the present invention;

[0017] Figure 2It is a schematic diagram of the sample state before and after the heat resistance test of the present invention;

[0018] Figure 3 It is a schematic diagram of the sample status before and after the cold resistance test of the present invention;

[0019] Figure 4 This is a picture of the whitening essence milk under a microscope of the present invention;

[0020] Figure 5 The whitening essence milk of the present invention under a microscope at different storage times;

[0021] Figure 6 The visual appearance (a) and microscopic morphology (b) of the whitening essence milk with different NaCl concentrations of the present invention are shown;

[0022] Figure 7 This is a graph showing the results of a skin irritation experiment for four consecutive weeks of the present invention;

[0023] Figure 8 It is a schematic diagram of the usage experience of the whitening essence lotion of the present invention. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] Embodiment 1:

[0026] See also Figures 1 to 7 As shown,

[0027] A whitening essence milk comprises the following raw materials in percentage by mass: 67.6% of deionized water, 1% of glycerol, 0.2% of carbomer, 0.2% of xanthan gum, 7% of 1-3 butylene glycol, 2% of D-panthenol, 2% of polysorbate 60, 0.2% of ethylhexylglycerol, 17.8% of olive oil and 2% of traditional Chinese medicine extract; the traditional Chinese medicine extract is a mixed extract of white peony root, atractylodes macrocephala, white poria cocos and liquorice, and the ratio of the white peony root, atractylodes macrocephala, white poria cocos and liquorice is 2:2:2:1.

[0028] A preparation method of a whitening essence milk, characterized in that it comprises the following steps:

[0029] S1. Preparation of Chinese herbal medicine extracts: 500 g each of white peony root, white atractylodes, white poria and licorice were weighed using an electronic scale, crushed using a grinder, passed through a 40-mesh sieve, and white peony root, white atractylodes, white poria and licorice were mixed evenly in a ratio of 2:2:2:1;

[0030] Weigh 14g of mixed medicinal powder and place it in a stoppered conical flask, add 56mL of 50% ethanol, and extract by ultrasonic at 40℃ for 30min. After filtering, take the supernatant as the Chinese medicine extract;

[0031] S2, mixing: glycerin, carbomer, xanthan gum, 1-3 butylene glycol and D-panthenol are added to deionized water, heated to 90°C, maintained for 15 min for sterilization, and cooled to 80°C for emulsification, wherein xanthan gum and carbomer are thickeners, which are added slowly to prevent agglomeration;

[0032] S3, mixing olive oil and polysorbate 60 evenly, heating to 80°C to dissolve, then adding ethylhexylglycerol to dissolve, and stirring continuously to obtain a mixed solution, and then adding it to the solution in S2 to mix evenly;

[0033] S4. Finally, slowly add the Chinese medicine extract in S1 to the mixed solution in S3, put it into a warm water bath oscillator, oscillate for 30 min at 37°C and 120 r / min, and then take it out to obtain a whitening essence lotion.

[0034] Specific;

[0035] Table 1 Whitening Essence Milk Formula

[0036]

[0037]

[0038] Experimental series, this experiment set the volume fraction of "Three Whites" Chinese herbal extracts to 2%, 4%, 6%, 8%, and 10% (as shown in Table 2), and prepared the corresponding essence milk according to the preparation process of the above-mentioned whitening essence milk, and then carried out DPPH free radical scavenging test and ABTS+ free radical scavenging test to detect its antioxidant effect. Through comparison, it was found that the whitening essence milk had the strongest antioxidant activity when the Three Whites extract was 2%. Therefore, the optimal addition amount of the "Three Whites" extract in the sample group in the whitening essence milk is 2%. According to this addition amount, a whitening essence milk was made with phases A and B, which was used in this experiment.

[0039] Table 2 Design and results of single factor experiment

[0040]

[0041] Stability evaluation of whitening essence lotion:

[0042] Appearance evaluation:

[0043] A small amount of the whitening essence milk sample of the present invention was taken for visual inspection at room temperature and without direct sunlight, and it was observed that the essence milk had a fine texture and uniform color, and the smell was pure.

[0044] pH determination:

[0045] Take an appropriate amount of whitening essence milk sample. Use pH test paper to measure its pH at room temperature to be 5.5 (such as Figure 1 ). Current research shows that the pH value of human skin surface ranges from 4.0 to 7.0, but most of it is acidic, between 5.4 and 5.9. Therefore, the pH value of general skin care products is best maintained between 4.0 and 8.5. The pH value of this product is within this range. Therefore, this product is qualified and can be used with confidence.

[0046] Heat resistance test:

[0047] Adjust the constant temperature incubator to 40℃ in advance and put the complete packaged whitening essence milk sample (such as Figure 2 Before) put it in a constant temperature incubator and take it out after 16 hours (such as Figure 2 After returning to room temperature, visual observation showed no abnormality compared with the original sample.

[0048] Cold resistance test:

[0049] Adjust the refrigerator to 2℃ in advance and put the complete package of whitening essence milk sample (such as Figure 3 Before) put it in the refrigerator and take it out after 24 hours (if Figure 3 After returning to room temperature, visual observation showed no abnormality compared with the original sample.

[0050] Centrifugation test

[0051] Inject the whitening essence sample into the centrifuge tube to about 2 / 3 of its height and cover it tightly. Then put it into an electric constant temperature incubator pre-adjusted to 38°C for 1 hour, and immediately move it into the centrifuge and adjust the centrifuge speed to 2000r / min. After rotating for 5min, take it out and observe whether there is any stratification.

[0052] Microscope observation

[0053] Place the whitening essence milk sample on a microscope slide, press it into a thin layer with a cover glass, expel the bubbles, fix the slide, magnify it 60 times, observe each sample and take pictures (such as Figure 4 ). It was found that the dispersed phase had uniform particle size, no obvious aggregation occurred between the droplets, and the emulsion was fine.

[0054] Storage stability

[0055] The newly prepared whitening essence milk samples were stored at room temperature for 3 months, and the average droplet size and visual appearance of the "Jiaohao" whitening essence milk samples under a microscope were recorded on the first day, at the end of the first month, and at the end of the third month. Figure 5As shown, through observation, it was found that the emulsion did not undergo phase separation after three months, the fluidity was good, and the droplet size did not change significantly, indicating that the emulsion has good storage stability and can be stored for a long time.

[0056] Ionic Strength Stability:

[0057] An appropriate amount of NaCl solution was added to the whitening essence milk, so that the NaCl concentration in the aqueous phase was 0M, 0.1M, 0.2M, 0.3M, and 0.4M, respectively. Then, the "Jiaohua" whitening essence milk samples with different ionic strengths were prepared according to the preparation method of the emulsion in 1.2.4, and the visual appearance of the samples under a microscope and the change in the average droplet size were observed after storage at room temperature for 24 hours. The visual appearance of the samples is as follows Figure 6 As shown in (a), it can be seen that there is no obvious phase separation and de-oiling phenomenon in the appearance of the emulsion under different ion concentrations, indicating that the emulsion can exist stably under different ionic strengths. Figure 6 As shown in (b), with the increase of NaCl concentration, the average droplet size of the emulsion did not change significantly, from which it can be concluded that the emulsion can maintain strong stability under different ion concentrations.

[0058] Safety evaluation of whitening essence milk:

[0059] Skin irritation test and sensory evaluation

[0060] 17 volunteers with healthy skin were randomly selected and applied whitening essence lotion on their left forearms for 4 weeks. Figure 7 As shown, the skin was smooth, delicate, supple and shiny, with no adverse reactions such as redness, itching and rash, and the skin reaction was grade 0. The volunteers also rated the essence milk in eight aspects: smell, mildness, greasiness, viscosity, spreadability, absorption, moisturizing and smoothness. The evaluation criteria were 10 points for each item, 1-3 points for poor, 4-6 points for average, and 7-10 points for excellent. The overall evaluation was conducted by counting the scores of the volunteers and calculating the average value of each item. The results are shown in Table 3 and Figure 8 shown.

[0061] Table 3 Subjective evaluation table of whitening essence milk trial

[0062]

[0063]

[0064] The evaluation results show that the whitening essence developed by this institute has a good overall effect. It is non-irritating to the skin in long-term trials, relatively mild, of excellent quality, and has good moisturizing and spreadability. However, this product also has problems such as unpleasant smell and greasy feeling after application. These problems reflected by the volunteers were also considered by our team during the development process. However, due to the original intention of this product to allow more people, including those prone to allergies, to use whitening products, and considering that a certain group of people are prone to allergies and redness and swelling to fragrance ingredients, this product does not contain any fragrance flavor enhancers.

[0065] Evaluation of the efficacy of whitening essence lotion

[0066] Determination of antioxidant properties

[0067] (1) DPPH free radical scavenging test

[0068] The body's oxidative reactions produce active free radicals such as ·OH and O2-. ·OH reacts with components such as nucleic acids and proteins in living cells to produce lipid peroxides that are deposited on the cell membrane, causing loss of membrane function and reduced cell viability. O2- can react with a variety of active substances in the cell membrane and blood in the body, causing cell apoptosis and aging. Therefore, the clearance rate of ·OH and O2- can be used as one of the important indicators to measure antioxidant capacity.

[0069] The sample group and the control group (as shown in Table 4) were reacted with the DPPH solution for 10 min under dark conditions, and the absorbance was measured at 517 nm to calculate the DPPH free radical scavenging rate. The DPPH free radical scavenging rate of the sample was calculated according to the following formula.

[0070] DPPH free radical scavenging rate = [1-Ai / Ac] × 100%

[0071] Wherein: Ai is the absorbance of the mixture of DPPH solution and essence milk test solution; Ac is the absorbance of DPPH solution.

[0072] ABTS+ free radical scavenging experiment

[0073] The sample group and the control group (as shown in Table 4) were reacted with ABTS+ solution for 10 min under light-proof conditions, and the absorbance was measured at 734 nm to calculate the ABTS+ free radical scavenging rate. The ABTS+ free radical scavenging rate was calculated according to the following formula.

[0074] ABTS+ free radical scavenging rate (%) = [1-(T-T0) / (C-C0)] × 100%

[0075] Where: T—absorbance of sample tube, i.e. absorbance of solution after sample reacts with ABTS

[0076] To—Sample background absorbance

[0077] C—ABTS tube absorbance value

[0078] Co—Solvent background absorbance

[0079] Control group setting

[0080] According to the 2% optimal addition amount obtained from the single factor experiment, the extracts of each component and the two phases A and B in the essence milk formula were taken to prepare the essence milk corresponding to each component, which was used as three groups of controls (as shown in Table 4). The antioxidant capacity was determined by DPPH free radical scavenging test and ABTS+ free radical scavenging test (as shown in Table 5). The comparison showed that the "three white" extract had the strongest antioxidant performance, that is, the whitening effect was the most obvious.

[0081] Table 4. Control group settings

[0082]

[0083] Table 5 Antioxidant test results

[0084]

[0085] In summary, this project is guided by the theory of traditional Chinese medicine, and uses the medicinal materials white peony, white atractylodes, white poria, and licorice in the ancient recipe "Sanbai Tang" that has been passed down for hundreds of years as raw materials. The active ingredients are extracted and added to the lotion to develop a multi-effect essence lotion with whitening, moisturizing, and antioxidant effects. The "Jiaohua" whitening essence lotion adopts the method of adding natural Chinese herbal medicine to truly achieve zero addition of artificially synthesized chemical whitening ingredients. It is gentle and non-irritating, plays a whitening role, greatly reduces the symptoms of human allergies, and is available for more people. The stability of the product is evaluated by evaluating its appearance, pH value, heat resistance, cold resistance test, centrifugation test, electron microscope observation of microstructure, storage stability, and ionic strength stability; the safety is evaluated by the skin feeling after direct use; and the whitening and antioxidant effects are evaluated from the perspective of DPPH antioxidant performance and ABTS+ antioxidant performance by designing a control test. This product has a mild effect, low irritation, and high safety. Consumers can feel the charm of traditional Chinese medicine while using this product for whitening and skin care. In summary, this project inherits the skin care inspiration from ancient books, explains the mechanism of action of traditional Chinese medicine from a modern perspective, gives full play to the advantages of our country's traditional projects, and expands the application of characteristic Chinese medicine resources in the field of whitening cosmetics.

[0086] It will be appreciated that in the development of any actual implementation, as in any engineering or design project, numerous implementation-specific decisions may be made. Such a development effort may be complex and time-consuming, but will be a routine task of design, fabrication, and production for those of ordinary skill having the benefit of this disclosure without undue experimentation.

[0087] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.

Claims

1. A whitening essence lotion and a preparation method thereof, characterized in that: The essence milk comprises the following raw materials in percentage by mass: 67.6% of deionized water, 1% of glycerol, 0.2% of carbomer, 0.2% of xanthan gum, 7% of 1-3 butylene glycol, 2% of D-panthenol, 2% of polysorbate 60, 0.2% of ethylhexylglycerol, 17.8% of olive oil and 2% of traditional Chinese medicine extract; the traditional Chinese medicine extract is a mixed extract of white peony root, atractylodes macrocephala, white poria cocos and licorice, and the ratio of the white peony root, atractylodes macrocephala, white poria cocos and licorice is 2:2:2:

1.

2. The preparation method of a whitening essence lotion according to claim 1, characterized in that: The following steps are involved: S1. Preparation of Chinese herbal medicine extracts: 500 g each of white peony root, white atractylodes, white poria and licorice were weighed using an electronic scale, crushed using a grinder, passed through a 40-mesh sieve, and white peony root, white atractylodes, white poria and licorice were mixed evenly in a ratio of 2:2:2:1; Weigh 14g of mixed medicinal powder and place it in a stoppered conical flask, add 56mL of 50% ethanol, and extract by ultrasonic at 40℃ for 30min. After filtering, take the supernatant as the Chinese medicine extract; S2, mixing: glycerol, carbomer, xanthan gum, 1-3 butylene glycol and D-panthenol are added to deionized water, heated to 90°C, maintained for 15 minutes for sterilization, and cooled to 80°C for emulsification, wherein xanthan gum and carbomer are thickeners, which are added slowly to prevent agglomeration; S3, mixing olive oil and polysorbate 60 evenly, heating to 80°C to dissolve, then adding ethylhexylglycerol to dissolve, and stirring continuously to obtain a mixed solution, and then adding it to the solution in S2 to mix evenly; S4. Finally, slowly add the Chinese medicine extract in S1 to the mixed solution in S3, put it into a warm water bath oscillator, oscillate at 37°C and 120 r / min for 30 minutes, then take it out to obtain the whitening essence lotion.

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