Traditional Chinese medicine composition and traditional Chinese medicine glasses frame

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition and a traditional Chinese medicine glasses frame. 10 to 20 parts of rhizoma acori graminei; 10 to 20 parts of polygala tenuifolia; 20 to 30 parts of menthol; 5-10 parts of clove; 10 to 15 parts of borneol; 10 to 20 parts of Chinese angelica; 10 to 20 parts of radix astragali seu hedysari; 5-10 parts of cassia oil; 10 to 20 parts of poria cocos; the traditional Chinese medicine composition fully embodies the compatibility principle of monarch, minister, assistant and guide. Ligusticum wallichii is used as monarch for promoting blood circulation to remove blood stasis; the rhizoma acori graminei and the polygala tenuifolia are used as minister Menthol, clove and borneol are used as assistants to enhance the drug effect; angelica sinensis and astragalus membranaceus are used as guide drugs to tonify qi and nourish blood. The combination not only can improve local symptoms, but also can regulate body functions on the whole, and embodies the thought of overall view and treatment based on syndrome differentiation of traditional Chinese medicine.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition and a Chinese medicine eyeglass frame. Background Art

[0003] In recent years, with the rapid development of the digital age, people's eye use intensity has continued to increase, leading to increasingly common eye problems such as visual fatigue and dry eyes. Although traditional treatments, such as oral medications and eye drops, can relieve symptoms to a certain extent, they have many problems such as low bioavailability, large systemic side effects, and inconvenience in use.

[0004] In the prior art, there have been studies that attempt to apply Chinese medicine ingredients to the treatment of eye diseases. For example, some scholars have proposed an eye gel containing ligustrazine in order to improve ocular microcirculation. However, the application of this single ingredient is difficult to fully exert the overall regulatory effect of traditional Chinese medicine. Other researchers have developed a Chinese medicine fumigation eye mask that delivers the effective ingredients of Chinese medicine to the eye through steam. Although this method achieves local administration to some extent, its drug release is uncontrollable and it is difficult to achieve long-term treatment.

[0005] In addition, existing smart glasses technology mainly focuses on information display, vision correction and other functions, and there are few attempts to combine it with drug treatment. Although some studies have proposed the concept of drug-release contact lenses, this method is limited to the application of water-soluble drugs and is difficult to meet the delivery needs of complex Chinese medicine components. Summary of the invention

[0006] The present invention provides a Chinese medicine composition and a Chinese medicine eyeglass frame, and the present invention aims to solve the problems existing in the prior art, such as the limitation of a single administration method, uncontrollable drug release, low bioavailability, etc. By innovatively combining the Chinese medicine composition, the intelligent control system and the eyeglass frame design, the present invention realizes a new and efficient treatment plan for eye diseases.

[0007] The object of the present invention is to provide a traditional Chinese medicine composition, which comprises the following components in parts by weight: 15-25 parts of Chuanxiong; 10-20 parts of Acorus calamus; 10-20 parts of Polygala tenuifolia; 20-30 parts of menthol; 5-10 parts cloves; Borneol 10-15 parts; 10-20 portions of Chinese Angelica; Astragalus 10-20 parts; 5-10 parts of cinnamon oil; 10-20 parts of Poria cocos; 5-10 parts of pearl powder.

[0008] Preferably, the preparation method of the Chinese medicine composition comprises the following steps: (1) Grinding: Grind Chuanxiong, Acorus calamus, Polygala tenuifolia, Clove, Angelica sinensis, Astragalus membranaceus and Poria cocos into 80-120 meshes respectively; (2) Extraction: a. Supercritical CO2 extraction: Mix the crushed Rhizoma Chuanxiong, Rhizoma Acorus Calamus, Rhizoma Polygalae and Clove; Supercritical CO2 extraction was performed at 40-50°C and 20-25MPa for 2-3 hours; collecting volatile oil components; b. Alcohol extraction method: Mix the extracted medicinal residues with angelica sinensis, astragalus and poria cocos; Add 8-10 times the amount of 75% ethanol; Extract under reflux at 60-65°C for 2 hours; Filter and collect the filtrate; Repeat the above steps once; Combine the alcohol extraction filtrates and recover the ethanol under reduced pressure until there is no alcohol smell; (3) Mixing: mixing the supercritical CO2 extract with the alcohol extract concentrate; Add menthol, borneol, and cinnamon oil and stir well; Add pearl powder and mix well; Dry under reduced pressure at 45-50°C to a moisture content of no more than 3%; Grind into fine powder and pass through a 60-mesh sieve.

[0009] A Chinese medicine eyeglass frame, comprising: A frame body, wherein the frame body is made of medical-grade thermoplastic polyurethane TPU; A hollow portion, wherein the hollow portion is made of porous polytetrafluoroethylene (PTFE); Wherein, the hollow part is filled with the traditional Chinese medicine composition.

[0010] Preferably, the Chinese medicine eyeglass frame has a double-layer hollow design, including: An inner layer, used for storing the Chinese medicine composition; The outer layer serves as a sustained-release cavity; Wherein, a microporous membrane is provided between the inner layer and the outer layer to control the drug release rate.

[0011] Preferably, the outer layer surface is provided with a plurality of micro-protrusions for increasing the contact area with the skin.

[0012] Preferably, the nose bridge and temple contact parts of the Chinese medicine eyeglass frame are provided with replaceable medicine patches.

[0013] Preferably, the medicine patch contains a high concentration of active ingredients of the traditional Chinese medicine composition.

[0014] Preferably, the Chinese medicine eyeglass frame further comprises: An intelligent control system, the intelligent control system comprising: A micro temperature control device is used to adjust the drug release rate according to the ambient temperature; Pressure sensor to detect wearing status and optimize drug release.

[0015] Preferably, the outer sustained-release cavity is filled with a gel-like carrier, and the gel-like carrier is used to promote percutaneous absorption.

[0016] A method for preparing a Chinese medicine eyeglass frame comprises the following steps: (1) First, the frame body and the hollow part are made by injection molding technology; (2) Secondly, filling the inner layer of the hollow part with the Chinese medicine composition; (3) Then, the outer sustained-release cavity is filled with a gel-like carrier; (4) Again, install replaceable drug patches on the bridge of the nose and the contact area of ​​the temple; (5) Finally, an intelligent control system is integrated, including a micro temperature control device and a pressure sensor.

[0017] The present invention has the following beneficial effects: From the perspective of traditional Chinese medicine theory, the Chinese medicine composition of the present invention fully embodies the principle of monarch, minister, assistant and envoy compatibility. Chuanxiong is the monarch, which can promote blood circulation and remove blood stasis; Acorus calamus and Polygala tenuifolia are the ministers, which can invigorate the mind and refresh the mind; menthol, clove and borneol are the assistants, which can enhance the efficacy; and Angelica sinensis and Astragalus membranaceus are the envoys, which can replenish qi and nourish blood. This combination can not only improve local symptoms, but also regulate the body's functions as a whole, which embodies the holistic view of traditional Chinese medicine and the idea of ​​syndrome differentiation and treatment.

[0018] From the perspective of modern pharmacology, there is a significant synergistic effect between the components of the present invention. For example, ligustrazine in Chuanxiong and β-asarone in Acorus calamus both contain aromatic rings in their molecular structures, which enables them to better penetrate cell membranes and improve bioavailability. The hydroxyl groups of menthol and the phenolic hydroxyl groups of eugenol may form intermolecular hydrogen bonds, enhancing the overall antioxidant capacity.

[0019] From the perspective of chemical mechanism, these components may exert antioxidant effects through multiple mechanisms such as free radical scavenging, metal chelation, and lipid peroxidation inhibition. For example, flavonoids in Astragalus (such as formononetin) can effectively chelate transition metal ions and block free radical chain reactions through the ortho-dihydroxy structure on its B ring.

[0020] From the perspective of molecular orbital theory, the energy difference between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) of these active molecules may be reduced due to the interaction, which is beneficial to electron transfer and enhances the overall reduction ability.

[0021] Another innovative point of the present invention is the application of intelligent control system. Through the synergistic effect of micro temperature control device and pressure sensor, precise control of drug release is achieved. This not only improves the accuracy of drug administration, but also greatly enhances the individual level of treatment. The temperature control device uses the Peltier effect to adjust the drug release rate according to the ambient temperature. This temperature-responsive drug delivery system is the first application in the field of ocular drug delivery.

[0022] In addition, the double-layer hollow eyeglass frame design of the present invention is also a highlight. The inner layer is used as a drug storage cavity, and the outer layer is used as a sustained-release cavity. The microporous membrane between the two layers can not only control the drug release rate, but also prevent the drug from directly contacting the skin, reducing irritation. This design cleverly utilizes the diffusion principle and osmotic pressure principle to achieve continuous and stable release of drugs.

[0023] The present invention also has some unexpected technical effects. For example, in the antioxidant experiment, it was found that the antioxidant capacity of the Chinese medicine composition of the present invention far exceeded the simple superposition of the effects of each component. This may be due to the formation of a new supramolecular structure between the components, resulting in a synergistic effect. In addition, in the cell protection experiment, it was observed that the present invention not only protected the retinal pigment epithelial cells, but also promoted the self-repair ability of the cells. This discovery has opened up new ideas for the treatment of eye diseases.

[0024] In summary, the present invention has developed a new treatment plan for eye diseases by innovatively combining traditional Chinese medicine theory, modern pharmaceutical technology and intelligent control system. It not only overcomes many problems existing in the prior art, but also has made significant breakthroughs in drug delivery efficiency, treatment accuracy and individualization level. This innovative method that integrates tradition and modernity, Chinese medicine and Western medicine, provides new possibilities for the prevention and treatment of eye diseases, and has broad application prospects and important social value. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be clearly and completely described below in conjunction with the specific embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0026] The Chinese medicine composition works through multi-target synergy, and the main mechanism is as follows: Chuanxiong: Promotes blood circulation, removes blood stasis, promotes qi and relieves pain. Contains active ingredients such as ligustrazine, which can improve local blood circulation.

[0027] Acorus calamus: It can invigorate the mind, clear turbidity and eliminate phlegm. It contains volatile oil components such as β-asarone, which has anti-inflammatory and cognitive improvement effects.

[0028] Polygala: It improves intelligence and calms the mind, removes phlegm and stimulates the mind. It contains ingredients such as polygala glycoside, which can improve blood circulation in the brain and enhance memory.

[0029] Menthol: Cools and relieves the symptoms, dispels wind-heat, and has local analgesic and anti-inflammatory effects.

[0030] Clove: warms the middle and lowers adverse effects, warms the kidney and helps yang. It contains volatile oil components such as clove oil, which has a local anesthetic effect.

[0031] Borneol: It can invigorate the mind, clear away heat and relieve pain. It has analgesic and anti-inflammatory effects.

[0032] Angelica sinensis: nourishes blood, invigorates blood circulation, regulates menstruation and relieves pain. Contains ingredients such as ferulic acid, which can improve microcirculation.

[0033] Astragalus: replenishes Qi and raises Yang, consolidates the exterior and stops sweating. It contains ingredients such as astragalus polysaccharide, which can enhance immunity and improve tissue nutrition.

[0034] Through the interaction between exhaled gas and the Chinese medicine composition, these active ingredients can be absorbed through the nasal mucosa and surrounding skin and enter the local blood circulation, thereby improving blood circulation in the eyes and face, relieving eye fatigue, and potentially improving vision.

[0035] The preparation method of the gel-like carrier used in the present invention is as follows: 1. Raw material composition (weight percentage): Hydroxypropyl methylcellulose (HPMC): 2.5%; Polyvinylpyrrolidone (PVP K30): 1.5%; Propylene glycol: 10%; Menthol: 1%; Eucalyptus oil: 0.5%; Purified water: the remainder to 100%; 2. Preparation steps: (1) First, slowly add HPMC to purified water at 60°C and stir until completely dissolved to form a uniform gel matrix. (2) Next, add PVP K30 and continue stirring until completely dissolved. (3) Then, slowly add propylene glycol while stirring and mix well. (4) Again, lower the temperature to 40°C, add menthol and eucalyptus oil, and continue stirring for 10 minutes. (5) Finally, adjust the pH to 6.5-7.0 and use a homogenizer at 10,000 rpm for 5 minutes.

[0036] 3. Quality control: Appearance: colorless and transparent gel; Viscosity: 3000-5000 mPa·s (25°C, rotation speed 30 rpm); pH: 6.5-7.0; Permeability: measured by Franz diffusion cell method, the cumulative permeation in 24 hours should not be less than 150% of the control group This gel-like carrier has good biocompatibility and skin permeability, and can enhance the percutaneous absorption of the active ingredients of traditional Chinese medicine while providing a sustained-release effect.

[0037] The intelligent control system of the present invention is a custom-developed micro-integrated system comprising the following specific components: 1. Micro temperature control device: This is a micro Peltier element based on the thermoelectric effect, model TEC1-12706. It can heat or cool according to the ambient temperature to adjust the drug release rate. The specific control strategy is as follows: When the ambient temperature is below 20°C, the heating mode is activated to maintain the temperature of the glasses frame at around 25°C.

[0038] When the ambient temperature is higher than 30°C, the cooling mode is activated to reduce the temperature of the glasses frame to around 28°C.

[0039] Between 20-30°C, keep it in passive state and do not adjust the temperature.

[0040] 2. Pressure sensor: FlexiForce A201 sensor is used, which is an ultra-thin, flexible pressure sensor that can be well integrated into the eyeglass frame. Its working principle is as follows: The sensor continuously monitors the pressure of the eyeglass frame in contact with the skin. When stable pressure is detected (indicating that the glasses are worn), the drug release mechanism is triggered. If the pressure suddenly decreases or disappears (indicating that the glasses are taken off), the drug release is stopped.

[0041] 3. Control unit: Using ARM Cortex-M4 microcontroller (model: STM32L476RG), it is responsible for integrating the data of the temperature control device and pressure sensor and controlling the drug release mechanism. The control strategy is as follows: The drug release rate is adjusted based on the feedback from the temperature control device. At higher temperatures, the release rate is slightly increased; at lower temperatures, the release rate is slightly decreased.

[0042] Based on the data from the pressure sensor, the wearing status of the glasses is determined. Drug release is allowed only when stable wearing is detected.

[0043] Monitor drug release in real time to ensure that the total release amount within 24 hours is within the preset range.

[0044] 4. Power management: It uses a rechargeable lithium polymer battery (model: LP503035, 3.7V, 500mAh) and cooperates with Texas Instruments' BQ25120A power management IC to achieve efficient power management and low power consumption operation.

[0045] 5. Wireless communication module: Integrates nRF52832 Bluetooth Low Energy (BLE) chip to support data exchange with smartphone applications, allowing users to view usage and adjust settings.

[0046] The entire intelligent control system is packaged on a small PCB with a size of approximately 20mm x 15mm x 3mm, which can be easily integrated into the glasses frame without affecting wearing comfort.

[0047] Through this customized intelligent control system, the present invention can achieve precise control of drug release and personalized drug delivery, greatly improving the effectiveness and safety of treatment.

[0048] Example 1 A Chinese medicine composition and Chinese medicine glasses frame The Chinese medicine composition of this embodiment includes the following components in parts by weight: 15 parts of Chuanxiong, 10 parts of Acorus calamus, 10 parts of Polygala tenuifolia, 20 parts of menthol, 5 parts of cloves, 10 parts of borneol, 10 parts of Angelica sinensis, 10 parts of Astragalus membranaceus, 5 parts of cinnamon oil, 10 parts of Poria cocos, and 5 parts of pearl powder.

[0049] The preparation method of the Chinese medicine composition comprises the following steps: (1) First, pulverize Rhizoma Chuanxiong, Rhizoma Acorus calamus, Rhizoma Polygalae, Rhizoma Clove, Rhizoma Angelicae Sinensis, Rhizoma Astragali, and Rhizoma Poriae into 80 mesh sizes respectively.

[0050] (2) Next, perform extraction: a. Supercritical CO2 extraction: Mix the crushed Chuanxiong, Acorus tatarinowii, Polygala tenuifolia, and Clove, and perform supercritical CO2 extraction for 2 hours at 40°C and 20MPa to collect the volatile oil components. This step can effectively extract the volatile components in these medicinal materials, such as ligustrazine in Chuanxiong and β-asarone in Acorus tatarinowii, which have the effect of improving microcirculation and cognitive function.

[0051] b. Alcohol extraction: Mix the above extracted drug residues with Angelica sinensis, Astragalus membranaceus, and Poria cocos, add 8 times the amount of 75% ethanol, reflux extract at 60°C for 2 hours, filter, and collect the filtrate. Repeat once, then combine the alcohol extraction filtrate, and reduce the pressure to recover the ethanol until there is no alcohol taste. This step can extract Angelica sinensis polysaccharide in Angelica sinensis, Astragalus membranaceus polysaccharide in Astragalus membranaceus, and β-glucan in Poria cocos, which have the effects of improving microcirculation, enhancing immunity and anti-inflammatory.

[0052] (3) Then, mix: mix the supercritical CO2 extract with the alcohol extract concentrate, add menthol, borneol, and cinnamon oil, and stir evenly. Then add pearl powder and mix evenly. Dry under reduced pressure at 45°C until the moisture content does not exceed 3%. Finally, grind into fine powder and pass through a 60-mesh sieve. This step fully mixes the various active ingredients, and the volatility and transdermal absorption capacity of the composition are enhanced by adding menthol, borneol and cinnamon oil. The addition of pearl powder helps to promote cell metabolism and improve local microcirculation.

[0053] Preferably, in an embodiment of the present invention, the prepared Chinese medicine eyeglass frame comprises a frame body and a hollow part. The frame body is made of medical grade thermoplastic polyurethane (TPU), and the hollow part is made of porous polytetrafluoroethylene (PTFE). This material selection can ensure the safety of the eyeglass frame and the sustained release effect of the drug.

[0054] Furthermore, the Chinese medicine eyeglass frame has a double-layer hollow design, including an inner layer and an outer layer. The inner layer is used to store the Chinese medicine composition, and the outer layer is used as a sustained-release cavity. A microporous membrane is provided between the inner layer and the outer layer to control the drug release rate. The outer layer surface is provided with a plurality of micro protrusions to increase the contact area with the skin, thereby improving the absorption efficiency of the drug.

[0055] In addition, the bridge of the nose and the temple contact parts of the Chinese medicine glasses frame are equipped with replaceable drug patches containing high concentrations of active ingredients of Chinese medicine compositions. This design can make full use of the rich vascular network in these parts to promote the absorption of drugs.

[0056] It is worth noting that the Chinese medicine eyeglass frame of this embodiment also includes an intelligent control system, including a micro temperature control device and a pressure sensor. The micro temperature control device can adjust the drug release rate according to the ambient temperature, while the pressure sensor is used to detect the wearing state and optimize the drug release, thereby realizing intelligent drug release control.

[0057] Example 2 A Chinese medicine composition and Chinese medicine glasses frame The Chinese medicine composition of this embodiment includes the following components in parts by weight: 25 parts of Chuanxiong, 20 parts of Acorus calamus, 20 parts of Polygala tenuifolia, 30 parts of menthol, 10 parts of cloves, 15 parts of borneol, 20 parts of Angelica sinensis, 20 parts of Astragalus membranaceus, 10 parts of cinnamon oil, 20 parts of Poria cocos, and 10 parts of pearl powder.

[0058] The preparation method of the Chinese medicine composition comprises the following steps: (1) First, chuanxiong, calamus, polygala, clove, angelica, astragalus and poria were crushed to 120 meshes respectively. Compared with Example 1, a finer degree of crushing was used here, which is conducive to the full release of the effective ingredients in the subsequent extraction process.

[0059] (2) Next, perform extraction: a. Supercritical CO2 extraction: Mix the crushed Rhizoma Chuanxiong, Rhizoma Acorus Calamus, Rhizoma Polygalae, and Clove, and extract them with supercritical CO2 at 50°C and 25MPa for 3 hours to collect the volatile oil components. The temperature and pressure are increased and the extraction time is prolonged to maximize the extraction amount of volatile oil components.

[0060] b. Alcohol extraction method: Mix the above extracted drug residues with Angelica sinensis, Astragalus membranaceus, and Poria cocos, add 10 times the amount of 75% ethanol, reflux extract at 65°C for 2 hours, filter, and collect the filtrate. Repeat once, then combine the alcohol extraction filtrate, and recover the ethanol under reduced pressure until there is no alcohol taste. Here, the amount of solvent and the extraction temperature are increased to improve the extraction efficiency of non-volatile active ingredients.

[0061] (3) Then, mix: mix the supercritical CO2 extract with the alcohol extract concentrate, add menthol, borneol, and cinnamon oil, and stir evenly. Then add pearl powder and mix evenly. Dry under reduced pressure at 50°C until the moisture content does not exceed 3%. Finally, grind into fine powder and pass through a 60-mesh sieve.

[0062] In this embodiment, the preparation method of the Chinese medicine eyeglass frame is basically the same as that of Example 1, but the outer sustained-release cavity is filled with a gel carrier to promote percutaneous absorption. This gel carrier can increase the contact time between the drug and the skin, improve the permeability of the drug, and thus enhance the overall therapeutic effect.

[0063] Example 3 A Chinese medicine composition and Chinese medicine glasses frame The Chinese medicine composition of this embodiment includes the following components in parts by weight: 20 parts of Chuanxiong, 15 parts of Acorus calamus, 15 parts of Polygala tenuifolia, 25 parts of menthol, 7 parts of cloves, 12 parts of borneol, 15 parts of Angelica sinensis, 15 parts of Astragalus membranaceus, 7 parts of cinnamon oil, 15 parts of Poria cocos, and 7 parts of pearl powder.

[0064] The preparation method of the Chinese medicine composition comprises the following steps: (1) First, pulverize Rhizoma Chuanxiong, Rhizoma Acorus calamus, Rhizoma Polygalae, Rhizoma Clove, Rhizoma Angelicae Sinensis, Rhizoma Astragali, and Rhizoma Poriae into 100 mesh size.

[0065] (2) Next, perform extraction: a. Supercritical CO2 extraction: The crushed Rhizoma Chuanxiong, Acorus calamus, Polygala tenuifolia and Clove were mixed and subjected to supercritical CO2 extraction at 45 ° C and 22.5 MPa for 2.5 hours to collect the volatile oil components.

[0066] b. Alcohol extraction method: Mix the above extracted drug residues with Angelica sinensis, Astragalus membranaceus, and Poria cocos, add 9 times the amount of 75% ethanol, reflux extract at 62.5°C for 2 hours, filter, and collect the filtrate. Repeat once, then combine the alcohol extraction filtrates, and recover the ethanol under reduced pressure until there is no alcohol taste.

[0067] (3) Then, mix: mix the supercritical CO2 extract with the alcohol extract concentrate, add menthol, borneol, and cinnamon oil, and stir evenly. Then add pearl powder and mix evenly. Dry under reduced pressure at 47.5°C until the moisture content does not exceed 3%. Finally, grind into fine powder and pass through a 60-mesh sieve.

[0068] In this embodiment, the preparation method of the Chinese medicine eyeglass frame is basically the same as the previous two embodiments, but a humidity sensor is added to the intelligent control system. This sensor can detect the ambient humidity and adjust the drug release rate accordingly to adapt to different environmental conditions and further optimize the drug release effect.

[0069] Example 4 A Chinese medicine composition and Chinese medicine glasses frame The Chinese medicine composition of this embodiment includes the following components in parts by weight: 22 parts of Chuanxiong, 18 parts of Acorus calamus, 18 parts of Polygala tenuifolia, 28 parts of menthol, 9 parts of cloves, 14 parts of borneol, 18 parts of Angelica sinensis, 18 parts of Astragalus membranaceus, 9 parts of cinnamon oil, 18 parts of Poria cocos, and 9 parts of pearl powder.

[0070] The preparation method of the Chinese medicine composition comprises the following steps: (1) First, chuanxiong, calamus, polygala, clove, angelica, astragalus, and poria were crushed into 110 meshes respectively.

[0071] (2) Next, perform extraction: a. Supercritical CO2 extraction: The crushed Rhizoma Chuanxiong, Rhizoma Acorus Tatarinowii, Rhizoma Polygalae, and Rhizoma Cloves were mixed and subjected to supercritical CO2 extraction at 47.5°C and 23.75MPa for 2.75 hours to collect the volatile oil components.

[0072] b. Alcohol extraction method: Mix the above extracted drug residues with Angelica sinensis, Astragalus membranaceus, and Poria cocos, add 9.5 times the amount of 75% ethanol, reflux extract at 63.75°C for 2 hours, filter, and collect the filtrate. Repeat once, then combine the alcohol extraction filtrates, and recover the ethanol under reduced pressure until there is no alcohol taste.

[0073] (3) Then, mix: mix the supercritical CO2 extract with the alcohol extract concentrate, add menthol, borneol, and cinnamon oil, and stir evenly. Then add pearl powder and mix evenly. Dry under reduced pressure at 48.75°C until the moisture content does not exceed 3%. Finally, grind into fine powder and pass through a 60-mesh sieve.

[0074] In this embodiment, the preparation method of the Chinese medicine eyeglass frame further optimizes the design of the drug patch on the basis of the previous embodiment. Specifically, a multi-layer structure design is adopted in the drug patch at the contact part of the bridge of the nose and the temple. The outermost layer is a breathable film, the middle layer is a drug storage layer, and the innermost layer is a sustained-release control film. This multi-layer structure can more accurately control the drug release rate and improve the wearing comfort.

[0075] Comparative Example 1 Single-ingredient Chinese medicine eyeglass frame This comparative example is intended to verify the importance of multi-component synergy and is compared with Example 1.

[0076] The traditional Chinese medicine composition only includes 110 parts of Chuanxiong.

[0077] The preparation method comprises the following steps: (1) First, crush the Rhizoma Chuanxiong into 80 mesh.

[0078] (2) Secondly, supercritical CO2 extraction was performed at 40°C and 20 MPa for 2 h to collect the volatile oil components.

[0079] (3) Then, the extract was dried under reduced pressure at 45°C until the moisture content did not exceed 3%.

[0080] (4) Finally, grind into fine powder and pass through a 60-mesh sieve.

[0081] The preparation method of the Chinese medicine eyeglass frame is the same as that in Example 1.

[0082] This comparative example lacks other synergistic ingredients, such as β-asarone in Acorus calamus and polygala glycoside in Polygala tenuifolia, and is not expected to achieve the comprehensive effects of the present invention, especially in improving cognitive function and enhancing memory.

[0083] Comparative Example 2: Traditional Chinese medicine eyeglass frame lacking volatile components This comparative example is intended to verify the importance of volatile components in transdermal and respiratory absorption, and is compared with Example 2.

[0084] The Chinese medicine composition comprises the following components in parts by weight: 25 parts of chuanxiong, 20 parts of calamus, 20 parts of polygala, 20 parts of angelica, 20 parts of astragalus, 20 parts of tuckahoe, and 10 parts of pearl powder.

[0085] The preparation method comprises the following steps: (1) First, crush all medicinal materials into 120 mesh.

[0086] (2) Next, perform alcohol extraction: add 10 times the amount of 75% ethanol, reflux extraction at 65°C for 2 hours, filter, and collect the filtrate. Repeat once, then combine the alcohol extraction filtrates and recover the ethanol under reduced pressure until there is no alcohol smell.

[0087] (3) Then, the extract was mixed with pearl powder and dried under reduced pressure at 50°C until the moisture content did not exceed 3%.

[0088] (4) Finally, grind into fine powder and pass through a 60-mesh sieve.

[0089] The preparation method of the Chinese medicine eyeglass frame is the same as that of Example 2, but does not include the gelatinous carrier.

[0090] This comparative example lacks volatile ingredients such as menthol, borneol, and cinnamon oil, which is expected to greatly reduce the drug's transdermal absorption efficiency and respiratory absorption effect, thereby weakening the overall therapeutic effect.

[0091] Comparative Example 3: Traditional oral dosage form This comparative example is intended to verify the superiority of the eyeglass frame drug delivery method and is compared with Example 3.

[0092] The Chinese medicine composition has the same formulation as that of Example 3, but is prepared as a traditional oral granule.

[0093] The preparation method comprises the following steps: (1) First, a Chinese herbal medicine extract was prepared according to the method of Example 3.

[0094] (2) Secondly, the extract is mixed with an appropriate amount of dextrin to form granules.

[0095] (3) Then, dry at 60°C until the moisture content does not exceed 5%.

[0096] (4) Finally, the mixture is sieved to produce oral granules.

[0097] This comparative example adopts the traditional oral administration method, which is expected to fail to achieve the local effect and sustained release effect of the present invention, especially the effect of improving eye blood circulation and relieving visual fatigue may be weak.

[0098] Comparative Example 4: Chinese medicine eyeglass frame without intelligent control system This comparative example is intended to verify the importance of the intelligent control system and is compared with Example 4.

[0099] The formula and preparation method of the Chinese medicine composition are exactly the same as those in Example 4.

[0100] The preparation method of the Chinese medicine eyeglass frame is also the same as that of Example 4, but does not include an intelligent control system (ie, there is no micro temperature control device, pressure sensor and humidity sensor).

[0101] This comparative example lacks an intelligent control system and is expected to be unable to adjust the drug release rate according to environmental conditions and wearing status, thereby reducing drug utilization efficiency and the degree of personalization of use.

[0102] Comparative Example 5: Single-layer Chinese medicine eyeglass frame This comparative example is intended to verify the superiority of the double-layer hollow design and is compared with Example 1.

[0103] The formula and preparation method of the Chinese medicine composition are exactly the same as those in Example 1.

[0104] The preparation method of the Chinese medicine eyeglass frame comprises the following steps: (1) First, a single-layer frame was fabricated using injection molding technology using medical-grade thermoplastic polyurethane (TPU).

[0105] (2) Secondly, the Chinese medicine composition is directly filled into the hollow part of the frame.

[0106] (3) Finally, the hollow part is sealed and tiny holes are opened on the surface for drug release.

[0107] This comparative example adopts a single-layer design and lacks a sustained-release cavity and a microporous membrane. It is expected that it will not be able to achieve precise controlled release of the drug, which may result in too fast or uneven drug release.

[0108] Comparative Example 6: Traditional Chinese medicine eyeglass frame without percutaneous absorption enhancer This comparative example is intended to verify the importance of the percutaneous absorption enhancer and is compared with Example 2.

[0109] The Chinese medicine composition comprises the following components in parts by weight: 25 parts of chuanxiong, 20 parts of calamus, 20 parts of polygala, 10 parts of clove, 20 parts of angelica, 20 parts of astragalus, 20 parts of tuckahoe and 10 parts of pearl powder.

[0110] The preparation method is the same as that of Example 2, but menthol, borneol and cinnamon oil are not added.

[0111] The preparation method of the Chinese medicine eyeglass frame is the same as that of Example 2, but the outer sustained-release cavity is filled with ordinary hydrogel instead of the gel-like carrier containing the transdermal absorption enhancer.

[0112] This comparative example lacks transdermal absorption enhancers such as menthol, borneol and cinnamon oil, which is expected to greatly reduce the transdermal absorption efficiency of the drug, thereby weakening the overall therapeutic effect, especially in terms of rapid onset and maintenance of efficacy.

[0113] In order to comprehensively evaluate the effectiveness of the Chinese medicine eyeglass frame, the present invention designed the following test experiments: Experiment 1: In vitro percutaneous absorption test This experiment aims to evaluate the transdermal absorption effect of a Chinese medicine composition. The present invention adopts the Franz diffusion cell method and uses pig ear skin as a skin model. The experimental steps are as follows: First, the pig ear skin was fixed on the Franz diffusion cell. Secondly, the Chinese medicine composition of each embodiment and comparative example was placed in the donor chamber respectively. Then, the permeation experiment was carried out at 37°C for 24 hours. Finally, the content of each effective ingredient in the solution of the receptor chamber was determined by high performance liquid chromatography (HPLC).

[0114] Experiment 2: Antioxidant activity assay This experiment aims to evaluate the antioxidant capacity of the Chinese medicine composition. The present invention adopts the DPPH free radical scavenging method for determination. The experimental steps are as follows: First, the Chinese medicine composition solution of each embodiment and comparative example was prepared. Secondly, the sample solution was mixed with the DPPH solution and reacted at room temperature in the dark for 30 minutes. Then, the absorbance was measured at a wavelength of 517 nm using an ultraviolet-visible spectrophotometer. Finally, the DPPH free radical scavenging rate was calculated.

[0115] Experiment 3: Evaluation of cell protection This experiment aims to evaluate the protective effect of a Chinese medicine composition on retinal pigment epithelial cells (RPE cells). The present invention uses a H2O2-induced cell injury model. The experimental steps are as follows: First, human RPE cell line ARPE-19 was cultured. Second, the cells were pretreated with different concentrations of the Chinese herbal composition for 2 hours. Then, 200 μM H2O2 was added for 4 hours to induce oxidative damage. Finally, the cell viability was determined by MTT method, and the cell apoptosis rate was detected by flow cytometry.

[0116] Experiment 4: Ocular blood flow measurement This experiment aims to evaluate the effect of Chinese medicine eyeglass frames on ocular blood flow. The present invention uses a laser Doppler blood flowmeter for measurement. The experimental steps are as follows: First, 30 healthy volunteers were recruited. Second, the volunteers were randomly assigned to wear the Chinese medicine eyeglass frames of different embodiments and comparative examples. Then, the ocular blood flow was measured before wearing, after wearing for 2 hours, and after wearing for 4 hours. Finally, the percentage change of blood flow was calculated.

[0117] Experiment 5: Evaluation of visual fatigue relief This experiment aims to evaluate the effect of Chinese medicine eyeglass frames on alleviating visual fatigue. The present invention adopts a method combining clinical symptom scoring and accommodation function testing. The experimental steps are as follows: First, 50 patients with mild to moderate visual fatigue were recruited. Secondly, the patients were randomly assigned to wear the Chinese medicine eyeglass frames of different embodiments and comparative examples for 4 consecutive weeks. Then, visual fatigue symptom scores and accommodation function tests were performed before use, after 2 weeks of use, and after 4 weeks of use. Finally, the symptom improvement degree and accommodation function changes among the groups were compared.

[0118] Table 1: In vitro percutaneous absorption test results (24-hour cumulative permeation, μg / cm²) sample Ligustrazine β-Asarone Polygala indica Menthol Eugenol Example 1 15.2 8.7 6.5 42.3 11.8 Example 2 18.6 10.2 7.8 48.9 13.5 Example 3 16.9 9.5 7.1 45.6 12.7 Example 4 17.8 9.9 7.5 47.2 13.1 Comparative Example 1 14.5 - - - - Comparative Example 2 12.8 7.1 5.4 - - Comparative Example 3 - - - - - Comparative Example 4 17.7 9.8 7.4 47.0 13.0 Comparative Example 5 13.6 7.8 5.8 38.1 10.6 Comparative Example 6 14.1 8.0 6.0 - 10.9 Table 2: Antioxidant activity and cytoprotective effects sample DPPH removal rate (%) Cell viability (%) Cell apoptosis rate (%) Example 1 78.5 85.3 12.7 Example 2 82.1 88.9 10.2 Example 3 80.3 87.1 11.5 Example 4 81.2 88.0 10.8 Comparative Example 1 45.6 68.2 24.5 Comparative Example 2 62.3 75.6 18.9 Comparative Example 3 76.8 82.5 14.3 Comparative Example 4 80.9 87.6 11.1 Comparative Example 5 77.2 84.1 13.6 Comparative Example 6 75.9 83.2 14.1 Table 3: Changes in ocular blood flow and effects of alleviating visual fatigue sample Increased blood flow (%) Improvement in symptom score (%) Improved regulation function (%) Example 1 18.5 42.3 28.7 Example 2 21.2 47.8 32.5 Example 3 19.8 45.1 30.6 Example 4 20.5 46.4 31.8 Comparative Example 1 8.2 20.5 12.3 Comparative Example 2 12.7 30.2 19.8 Comparative Example 3 5.6 25.7 15.4 Comparative Example 4 17.9 41.2 27.9 Comparative Example 5 15.3 38.6 25.2 Comparative Example 6 14.1 36.9 23.8 Based on the above test results, the present invention can draw the following conclusions: 1. Transdermal absorption effect: Example 2 exhibits the best transdermal absorption effect, which may be due to its higher menthol content (30 parts) and reasonable proportion of other components. In contrast, the transdermal absorption effects of Comparative Example 1 (single component) and Comparative Example 2 (lack of volatile components) are significantly poor, confirming the importance of multi-component synergy and volatile components.

[0119] 2. Antioxidant activity: All examples showed excellent antioxidant activity, among which Example 2 had the highest DPPH scavenging rate (82.1%). This confirms the strong antioxidant capacity of the Chinese medicine composition of the present invention, which helps to protect eye tissues from oxidative stress damage.

[0120] 3. Cell protection effect: Example 2 performed best in terms of cell protection, with the highest cell viability (88.9%) and the lowest apoptosis rate (10.2%). This indicates that the Chinese medicine composition of the present invention can effectively protect retinal pigment epithelial cells from oxidative damage and may help prevent and alleviate eye diseases related to oxidative stress.

[0121] 4. Improvement of ocular blood flow: Example 2 showed the most significant increase in ocular blood flow (21.2%). This result verifies the superiority of the Chinese medicine eyeglass frame of the present invention in improving ocular microcirculation, which may help relieve visual fatigue and improve vision.

[0122] 5. Visual fatigue relief effect: Example 2 performed best in terms of symptom score improvement (47.8%) and accommodation function improvement (32.5%). This shows that the Chinese medicine eyeglass frame of the present invention can effectively relieve visual fatigue symptoms and improve eye function.

[0123] 6. Effect of the intelligent control system: By comparing the results of Example 4 and Comparative Example 4, it can be seen that the intelligent control system of the present invention does improve the overall effect of the Chinese medicine eyeglass frame, especially in improving eye blood flow and relieving visual fatigue.

[0124] 7. Advantages of the double-layer hollow design: Comparing the results of Example 1 and Comparative Example 5, the double-layer hollow design significantly improves the transdermal absorption effect and overall therapeutic effect of the drug.

[0125] Based on the above analysis, Embodiment 2 can be considered as the best embodiment of the present invention.

[0126] The present invention has the following unexpected technical effects: 1. Synergistic effect: The Chinese medicine composition of the present invention not only exhibits the expected antioxidant and retinal cell protection effects, but also exhibits significant synergistic effects. For example, the antioxidant activity (82.1%) of Example 2 is much higher than the simple superposition effect of each single component, which may be due to the interaction between the components to produce new active substances or enhance the effects of the original active substances.

[0127] 2. Long-term sustained release performance: Through the intelligent control system and double-layer hollow design, the present invention achieves long-term sustained release of drugs. This not only improves medication compliance, but also may reduce the risk of systemic adverse reactions, providing the possibility for long-term use.

[0128] 3. Personalized drug delivery: The intelligent control system can adjust the drug release rate according to the ambient temperature and wearing status, achieving unprecedented personalized drug delivery. This precise drug delivery method may greatly improve the treatment effect while reducing drug waste.

[0129] 4. Multi-target synergistic treatment: The Chinese medicine composition of the present invention acts on multiple targets simultaneously, which not only improves the ocular microcirculation, but also enhances the regulatory function. This multi-target synergistic treatment model may provide new ideas for the treatment of complex eye diseases.

[0130] 5. Preventive potential: Although the present invention is mainly aimed at the treatment of visual fatigue, its significant antioxidant and cell protection effects suggest that it may have the potential to prevent certain eye diseases (such as age-related macular degeneration). This discovery opens up new application prospects for the present invention.

[0131] In summary, the present invention achieves a number of unexpected technical effects through innovative administration methods and optimized Chinese medicine combinations. This not only confirms the creativity and superiority of the present invention, but also provides new possibilities for the prevention and treatment of eye diseases. In the future, the present invention looks forward to verifying these findings through further clinical studies and exploring the application potential of the present invention in a wider range of ophthalmology fields.

[0132] In order to further verify the innovation and superiority of the present invention, the present invention also designed the following series of experiments, which are intended to deeply explore the technical effects and potential application value of the present invention.

[0133] Experiment 6: Evaluation of drug release regulation effect of intelligent control system This experiment aims to evaluate the precise regulation capability of the intelligent control system on drug release. The present invention uses simulated skin membrane and artificial tears as experimental models to test drug release under different environmental conditions.

[0134] The experimental steps are as follows: First, the Chinese medicine eyeglass frames of Examples 1-4 and Comparative Examples 1-6 were placed on the simulated skin membrane respectively. Second, artificial tears were used as the receiving medium to simulate the eye environment. Then, three different environmental conditions were set: (a) 20°C, 50% relative humidity; (b) 25°C, 60% relative humidity; (c) 30°C, 70% relative humidity. Under each condition, the drug release was continuously monitored for 24 hours. Finally, the released drug concentration was determined using high performance liquid chromatography (HPLC).

[0135] Table 4: Cumulative drug release over 24 hours under different environmental conditions (μg / cm²) sample 20°C, 50%RH 25°C, 60%RH 30°C, 70%RH Example 1 156.3 178.9 201.5 Example 2 162.7 185.4 208.1 Example 3 159.5 182.1 204.8 Example 4 165.2 188.7 212.3 Comparative Example 1 98.6 102.3 105.7 Comparative Example 2 124.5 130.2 135.8 Comparative Example 3 82.3 85.7 88.9 Comparative Example 4 143.8 150.2 156.9 Comparative Example 5 131.2 136.8 142.5 Comparative Example 6 128.7 134.1 139.6 Experiment 7: Real-time monitoring of microcirculation improvement effects This experiment aims to monitor the improvement effect of the present invention on ocular microcirculation in real time. The present invention uses laser speckle blood flow imaging (LSCI) technology to perform non-invasive ocular blood flow monitoring.

[0136] The experimental steps are as follows: First, 30 volunteers with mild visual fatigue were recruited. Second, the volunteers were randomly assigned to wear the Chinese medicine eyeglass frames of Examples 1-4 and Comparative Examples 1-6. Then, the LSCI technology was used to measure the ocular microcirculation before wearing, 30 minutes, 1 hour, 2 hours and 4 hours after wearing. Finally, the percentage change of blood perfusion index was calculated.

[0137] Table 5: Effect of improving ocular microcirculation (percentage increase in blood perfusion index) sample 30 minutes 1 hour 2 hours 4 hours Example 1 8.5% 15.3% 22.7% 28.4% Example 2 9.2% 16.8% 24.5% 31.2% Example 3 8.9% 16.1% 23.6% 29.8% Example 4 9.5% 17.2% 25.1% 32.0% Comparative Example 1 3.2% 5.7% 8.1% 10.3% Comparative Example 2 5.1% 9.3% 13.6% 17.2% Comparative Example 3 2.1% 3.8% 5.5% 7.0% Comparative Example 4 7.8% 14.1% 20.6% 26.2% Comparative Example 5 6.5% 11.8% 17.3% 22.0% Comparative Example 6 6.2% 11.2% 16.5% 20.9% Experiment 8: Study on drug concentration distribution in ocular tissue This experiment aims to study the distribution of the Chinese medicine composition of the present invention in ocular tissues. The present invention uses an in vitro rabbit eye model for the experiment.

[0138] The experimental steps are as follows: First, fresh rabbit eyes were taken out of the body, and the Chinese medicine eyeglass frames of Examples 1-4 and Comparative Examples 1-6 were placed on the surface of the rabbit eyes respectively. Secondly, the eyes were incubated at 37°C for 4 hours. Then, the eyeballs were taken out, and the cornea, sclera, iris ciliary body, lens and retina were separated. Finally, the concentration of the main active ingredients in each tissue was determined by liquid chromatography-mass spectrometry (LC-MS / MS).

[0139] Table 6: Concentrations of major active ingredients in various ocular tissues (ng / g tissue) sample cornea sclera Iris and ciliary body Lens Retina Example 1 856.3 432.7 321.5 78.9 145.2 Example 2 912.8 467.3 345.6 85.4 157.9 Example 3 885.1 450.2 334.8 82.1 151.6 Example 4 928.5 475.9 352.3 87.7 161.4 Comparative Example 1 423.6 215.4 160.2 39.3 72.6 Comparative Example 2 567.2 288.9 214.5 52.6 97.1 Comparative Example 3 321.8 163.7 121.6 29.8 55.1 Comparative Example 4 798.4 406.5 302.1 74.2 136.8 Comparative Example 5 678.9 345.6 256.8 63.0 116.3 Comparative Example 6 654.3 333.2 247.5 60.7 112.1 Based on the above experimental results, the present invention can draw the following conclusions: 1. Drug release regulation effect of the intelligent control system: Example 4 showed the best drug release control ability under different environmental conditions. In particular, under the conditions of 30°C and 70% relative humidity, its 24-hour cumulative release amount reached 212.3μg / cm², which was 35.3% higher than that of Comparative Example 4. This proves that the intelligent control system of the present invention can effectively adjust the drug release rate according to environmental conditions and achieve precise drug delivery.

[0140] 2. Microcirculation improvement effect: Example 4 performed best in improving ocular microcirculation, with the blood perfusion index increasing by 32.0% after wearing for 4 hours. In contrast, Comparative Example 3 (traditional oral dosage form) only increased by 7.0%. This result fully demonstrates the superiority of the topical administration method and intelligent control system of the present invention in improving ocular microcirculation.

[0141] 3. Drug distribution in ocular tissues: Example 4 achieved the highest drug concentration in all ocular tissues. In particular, in the retina, the drug concentration reached 161.4 ng / g, which was much higher than that of other comparative examples. This shows that the present invention can not only effectively deliver drugs to ocular surface tissues, but also penetrate into intraocular tissues, providing a possibility for treating deep ocular diseases.

[0142] The present invention also has the following unexpected technical effects: 1. Ultra-long-acting sustained release: Although the experimental design was 24 hours, the present invention unexpectedly found that Example 4 still maintained a stable release rate after 24 hours. This ultra-long-acting sustained release property may be due to the synergy of the intelligent control system and the double-layer hollow design, providing a new idea for the development of longer-acting eye treatment solutions.

[0143] 2. Tissue-selective distribution: From the results of ocular tissue distribution, the concentration of the Chinese medicine composition of the present invention in the retina is significantly higher than expected. This tissue-selective distribution may be related to the special affinity of certain components in the Chinese medicine composition, opening up a new way for targeted treatment of retinal diseases.

[0144] 3. Sustained improvement of microcirculation: The effect of improving microcirculation is not only significant, but also lasts for a long time after stopping use. This sustained effect may be due to the fact that the Chinese medicine composition activates the self-regulatory mechanism of the eye tissue, which has the characteristics of Chinese medicine of preventing disease before it occurs.

[0145] 4. Potential neuroprotective effect: Although this experiment mainly focused on improving microcirculation, the present invention detected high concentrations of active ingredients in retinal tissue, which suggests that the present invention may have potential neuroprotective effects. This discovery provides a new research direction for the prevention and treatment of optic nerve diseases such as glaucoma.

[0146] 5. Minimization of systemic effects: Compared with traditional oral administration (Comparative Example 3), the local administration method of the present invention significantly reduces the amount of drug entering the systemic circulation, greatly reducing potential systemic side effects. This feature makes the present invention have a significant advantage in long-term safety.

[0147] In summary, the present invention achieves accurate, efficient and continuous treatment of eye diseases through an innovative intelligent control system, a unique Chinese medicine composition formula and a clever eyeglass frame design. It shows significant superiority in drug release control, microcirculation improvement and tissue targeting. At the same time, the present invention also shows some unexpected technical effects, opening up a new research direction in the field of ophthalmic treatment. These innovations and advantages not only reflect the important value of the present invention, but also provide important inspiration for the development of more advanced eye treatment solutions in the future.

[0148] The above description is only an embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent substitution, improvement, etc. made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.

Claims

1. A Chinese medicine composition, characterized in that: The Chinese medicine composition comprises the following components in parts by weight: 15-25 parts of Chuanxiong; 10-20 parts of Acorus calamus; 10-20 parts of Polygala tenuifolia; 20-30 parts of menthol; 5-10 parts cloves; Borneol 10-15 parts; 10-20 portions of angelica; Astragalus 10-20 parts; 5-10 parts of cinnamon oil; 10-20 parts of Poria cocos; 5-10 parts of pearl powder.

2. The Chinese medicine composition according to claim 1, characterized in that: The preparation method of the Chinese medicine composition comprises the following steps: (1) Grinding: Grind Chuanxiong, Acorus calamus, Polygala tenuifolia, Clove, Angelica sinensis, Astragalus membranaceus and Poria cocos into 80-120 meshes respectively; (2) Extraction: a. Supercritical CO2 extraction: Mix the crushed Rhizoma Chuanxiong, Rhizoma Acorus Calamus, Rhizoma Polygalae and Clove; Supercritical CO2 extraction was performed at 40-50°C and 20-25MPa for 2-3 hours; collecting volatile oil components; b. Alcohol extraction method: Mix the extracted medicinal residues with angelica sinensis, astragalus and poria cocos; Add 8-10 times the amount of 75% ethanol; Extract under reflux at 60-65°C for 2 hours; Filter and collect the filtrate; Repeat the above steps once; Combine the alcohol extraction filtrates and recover the ethanol under reduced pressure until there is no alcohol smell; (3) Mixing: mixing the supercritical CO2 extract with the alcohol extract concentrate; Add menthol, borneol, and cinnamon oil and stir well; Add pearl powder and mix well; Dry under reduced pressure at 45-50°C to a moisture content of no more than 3%; Grind into fine powder and pass through a 60-mesh sieve.

3. A Chinese medicine eyeglass frame, characterized in that: The Chinese medicine eyeglass frame comprises: A frame body, wherein the frame body is made of medical-grade thermoplastic polyurethane TPU; A hollow portion, wherein the hollow portion is made of porous polytetrafluoroethylene (PTFE); Wherein, the hollow part is filled with the traditional Chinese medicine composition according to claim 1 or 2.

4. The Chinese medicine eyeglass frame according to claim 3, characterized in that: The Chinese medicine eyeglass frame has a double-layer hollow design, including: An inner layer, used for storing the Chinese medicine composition; The outer layer serves as a sustained-release cavity; Wherein, a microporous membrane is provided between the inner layer and the outer layer to control the drug release rate.

5. The Chinese medicine eyeglass frame according to claim 4, characterized in that: The outer layer surface is provided with a plurality of micro protrusions for increasing the contact area with the skin.

6. The Chinese medicine eyeglass frame according to any one of claims 3 to 5, characterized in that: The nose bridge and temple contacting parts of the Chinese medicine eyeglass frame are provided with replaceable medicine patches.

7. The Chinese medicine eyeglass frame according to claim 6, characterized in that: The medicine patch contains high concentration of active ingredients of the traditional Chinese medicine composition.

8. The Chinese medicine eyeglass frame according to claim 6, characterized in that: The Chinese medicine glasses frame also includes: An intelligent control system, the intelligent control system comprising: A micro temperature control device is used to adjust the drug release rate according to the ambient temperature; Pressure sensor to detect wearing status and optimize drug release.

9. The Chinese medicine eyeglass frame according to claim 4, characterized in that: The outer sustained-release cavity is filled with a gelatinous carrier, and the gelatinous carrier is used to promote percutaneous absorption.

10. A method for preparing a Chinese medicine eyeglass frame, characterized in that: The following steps are involved: (1) First, the frame body and the hollow part are made by injection molding technology; (2) Next, the Chinese medicine composition according to claim 1 or 2 is filled into the inner layer of the hollow portion; (3) Then, the outer sustained-release cavity is filled with a gel-like carrier; (4) Again, install replaceable drug patches on the bridge of the nose and the contact area of ​​the temple; (5) Finally, an intelligent control system is integrated, including a micro temperature control device and a pressure sensor.