A mechanically reinforced integrated three-dimensional micro / nanofiber scaffold and its fabrication method

Mechanically reinforced integrated three-dimensional micro/nanofiber scaffolds were prepared by electrospinning, foaming, and freeze-drying, which solved the problems of low mechanical properties and delamination of gas-foamed scaffolds, and realized the preparation and application of efficient and low-cost three-dimensional micro/nanofiber scaffolds.

CN119499446BActive Publication Date: 2025-10-28DONGHUA UNIV
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Patent Information

Application Number
CN202411651864.X
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-11-19
Publication Date
2025-10-28
Estimated Expiration
2044-11-19

AI Technical Summary

Technical Problem

Existing three-dimensional micro-nanofiber scaffolds obtained from gas-foamed micro-nanofiber membranes suffer from low mechanical properties, easy delamination, loose fiber stacking, and poor shape retention. Furthermore, they are difficult to process after post-processing, which limits their application scope.

Method used

After preparing micro/nanofiber membranes using electrospinning, foaming was performed using a foaming solution. Then, mechanically reinforced integrated three-dimensional micro/nanofiber scaffolds were formed by injection filling with sol B and freeze-drying. The foaming medium was optimized using sol A and sodium borohydride to form a continuous integrated interpenetrating network structure.

Benefits of technology

It significantly enhances the mechanical properties and overall stability of three-dimensional micro/nanofiber scaffolds, solves the delamination problem, provides multifunctionality and controllable surface treatment characteristics, expands the application range, and is simple to operate, low in cost, and suitable for mass production.

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Abstract

This invention belongs to the field of biomedical materials technology and discloses a mechanically reinforced integrated three-dimensional micro / nanofiber scaffold and its preparation method. The invention involves electrospinning hydrophilic and hydrophobic polymer materials to obtain micro / nanofiber membranes, then foaming them using a sol-containing foaming solution to obtain a three-dimensional micro / nanofiber scaffold. The scaffold is then filled with sol and freeze-dried to obtain a mechanically reinforced integrated three-dimensional micro / nanofiber scaffold. The three-dimensional micro / nanofiber material and the freeze-dried scaffold form a continuous, integrated interpenetrating network structure with good integrity, resistance to delamination, and significantly enhanced mechanical properties. It also exhibits superior and controllable surface post-processing characteristics, especially the bifacial anisotropic treatment, which allows for convenient and quick at imparting multifunctionality to the scaffold. Furthermore, the thickness can be flexibly and conveniently adjusted through pressing during application to meet different medical needs.
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