A method for constructing a characteristic map of a traditional Chinese medicine and the characteristic map thereof
The characteristic chromatogram of Zhikang capsules was constructed by high performance liquid chromatography, and 10 characteristic peaks were identified. This solved the problem that the existing quality standards could not fully reflect the overall quality of Zhikang capsules, and enabled strict control and stability assurance of product quality.
CN119510622BActive Publication Date: 2026-04-28XIAN CHIHO PHARMA
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Patent Information
- Application Number
- CN202411634629.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-15
- Publication Date
- 2026-04-28
- Estimated Expiration
- 2044-11-15
AI Technical Summary
Technical Problem
Existing quality standards cannot fully reflect the overall quality of Zhikang capsules, resulting in insufficient product quality control and affecting efficacy.
Method used
High performance liquid chromatography was used to construct the characteristic chromatogram of Zhikang capsules. Ten characteristic peaks were identified by gradient elution, gradient elution program and ultraviolet detection, including characteristic peaks of components such as dragon's blood, rhubarb and angelica, and a comprehensive quality control system was established.
Benefits of technology
This achieves high precision, repeatability, and solution stability in the quality control of Zhikang capsules, ensuring the consistency and stability of the product's intrinsic quality.
✦ Generated by Eureka AI based on patent content.
Abstract
The application discloses a method for constructing a characteristic map of a traditional Chinese medicine and the characteristic map, wherein the method adopts an HPLC method to determine the content of an effective component, imperatorin, in Zhikang capsules, and constructs a high performance liquid chromatography characteristic map of the Zhikang capsules; 10 characteristic peaks are determined as the characteristic map, which are respectively from dragon's blood, rhubarb and Bai Zhi; the components from the dragon's blood are dracorhodin B (peak 2) and pterostilbene (peak 4); the components from the rhubarb are peak 1 (aloe-emodin), peak 3, peak 6 (emodin), peak 9 and peak 10; and the components from the Bai Zhi are imperatorin (peak 5), peak 7 and peak 8; the method covers polyphenols, anthraquinones and furanocoumarins and other main components, and constructs a quality evaluation system of the Zhikang capsules; the method has good specificity, precision, repeatability and solution stability, and can be used for standardizing the production of the Zhikang capsules and guaranteeing the uniformity and stability of the internal quality of products to provide comprehensive quality control.
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