Gel for dredging nasal cavity and preparation method thereof

Abstract

The invention belongs to the technical field of medicine, and particularly relates to a nasal cavity dredging gel and a preparation method thereof.The nasal cavity dredging gel is prepared from, by weight, 1-2 parts of flos magnoliae, 1-2 parts of fructus xanthii, 1-2 parts of platycodon grandiflorum, 1-2 parts of mint, 2-3 parts of centipeda minima, 2-3 parts of schizonepeta, 1-2 parts of notopterygium roots, 1-2 parts of asarum, 1-2 parts of borneol, 2-3 parts of auxiliary materials and 20-30 parts of water. The traditional Chinese medicine composition has the advantages that the medicines are combined and matched with one another, the effects of eliminating phlegm, diminishing inflammation, relieving symptoms of patients, dispelling wind, relieving exterior syndrome, clearing away lung heat, dispelling wind-cold, enhancing the curative effect and avoiding relapse are achieved, the effects of treating both symptoms and root causes are achieved, the compatibility is strict, the formula is reasonable, the treatment effect is remarkable, the clinical treatment cycle is short, and the cure rate is high.

Description

Technical Field

[0001] The invention relates to the technical field of medicine, and in particular to a gel for clearing the nasal cavity and a preparation method thereof. Background Art

[0002] Rhinitis is a very common chronic inflammatory disease of the nasal mucosa, and its prevention and treatment are urgent. Due to environmental pollution, the number of patients with rhinitis is still increasing. Rhinitis is mainly characterized by persistent inflammation and microbial infection. Although it is not a serious disease, it has many complications involving nasal airway hyperresponsiveness, disorders of the nervous system and the release of neuropeptides, and is characterized by the appearance of certain symptoms, including itching, sneezing, runny nose, nasal congestion and daily changes in smell. Frequent onset of allergic rhinitis symptoms can seriously affect the patient's quality of life and work, and impose a huge burden on individuals and society. Therefore, research on the treatment of this disease has important clinical value.

[0003] There are many kinds of drugs commonly used in the clinical treatment of this disease, including hormones, antihistamines, mast cell stabilizers, decongestants and various Chinese medicines. Although these drugs have certain curative effects, most of them are single-ingredient preparations with single curative effects and are prone to drug resistance. In addition, the dosage forms are mostly solid oral preparations and liquid nasal drops. Although the prescription volume of oral Chinese medicine preparations is large, after the drug is absorbed in the body, it must first be metabolized by the liver and circulated through the blood to reach the nasal cavity. Most of the drugs have expired or cannot reach their effective concentrations. Moreover, the nasal cavity is filled with blood and the circulation is poor, resulting in unclear curative effects. Liquid nasal drops stay in the nasal cavity for too short a time. The best way is to quickly remove them from the mucociliary membrane of the nasal cavity. Repeated administration is very inconvenient for patients, and the compliance of clinical use is not satisfactory. In addition, this treatment method has a long cycle and is prone to relapse. In summary, the existing products for the treatment of rhinitis have the problem of long treatment cycles. Summary of the invention

[0004] In order to solve the above technical problems, the present invention provides a gel for clearing the nasal cavity and a preparation method thereof.

[0005] A gel for clearing the nasal cavity is prepared from the following raw materials in parts by weight: 1-2 parts of magnolia, 1-2 parts of Xanthium sibiricum, 1-2 parts of platycodon, 1-2 parts of mint, 2-3 parts of ophiopogon, 2-3 parts of schizonepeta, 1-2 parts of notopterygium, 1-2 parts of asarum, 1-2 parts of borneol, 2-3 parts of auxiliary materials and 20-30 parts of water.

[0006] Preferably, the auxiliary material is a mixture of an emulsifier, a thickener, a preservative, and an antibacterial agent;

[0007] The mass ratio of the emulsifier: thickener: preservative: antibacterial agent is 1-2:1-2:1-2:1-2.

[0008] Preferably, the emulsifier is any one of Poloxamer 188, Tween 20 and Tween 80.

[0009] Preferably, the thickener is any one of cationic guar gum, methylcellulose, hydroxypropyl methylcellulose and hyaluronic acid.

[0010] Preferably, the preservative is any one of parabens, benzalkonium chloride and chlorobutanol.

[0011] Preferably, the antibacterial agent is nanosilver.

[0012] A method for preparing a gel for clearing the nasal cavity comprises the following steps:

[0013] Weigh the emulsifier, thickener, preservative and antibacterial agent in a mass ratio of 1-2:1-2:1-2:1-2 to obtain an auxiliary material;

[0014] Weigh 1-2 parts of magnolia, 1-2 parts of Xanthium sibiricum, 1-2 parts of platycodon, 1-2 parts of mint, 2-3 parts of schefflera, 2-3 parts of schizonepeta, 1-2 parts of notopterygium, 1-2 parts of asarum, 1-2 parts of borneol, 2-3 parts of auxiliary materials, and 20-30 parts of water;

[0015] The weighed Angelica dahurica, Magnolia officinalis, Xanthium sibiricum, Platycodon grandiflorum, Mentha arvense, Herba Schisandrae Chinensis, Nepeta tenuifolia, Notopterygium wilfordii, Asarum sieboldii and water are mixed and heated for the first time to obtain a Chinese herbal medicine mixture;

[0016] The weighed borneol and auxiliary materials are mixed evenly, and heated for a second time to obtain an auxiliary material mixture;

[0017] The Chinese herbal medicine mixture and the auxiliary material mixture are mixed evenly, and heated for a third time to obtain the nasal cavity clearing gel;

[0018] Among them, the temperature of the first heating is higher than the temperature of the third heating, and the temperature of the third heating is higher than the temperature of the second heating.

[0019] Preferably, the temperature of the first heating is 80°C to 95°C.

[0020] Preferably, the temperature of the second heating is 40°C to 50°C.

[0021] Preferably, the temperature of the third heating is 60°C to 80°C.

[0022] Traditional Chinese medicine treats rhinitis by making overall diagnosis and regulating the functions of internal organs. It makes diagnosis and treatment based on clinical symptoms, i.e. itchy nose, sneezing, runny nose, nasal congestion, chills, heat intolerance, etc., combined with local examination, i.e. pale edema, congestion, blood stasis of nasal mucosa, clear or thick mucus, etc., as well as individual differences of patients and different seasons.

[0023] Magnolia has the effect of dispersing wind and cold and clearing the nasal orifices. It is suitable for symptoms such as wind-cold headache and nasal congestion.

[0024] Xanthium sibiricum is mainly used to dispel rheumatism and clear the nasal passages. It has a good effect on wind-cold headaches and runny nose caused by sinusitis.

[0025] Platycodon grandiflorum can clear the lungs, relieve sore throat, and eliminate phlegm, which helps to clear the nasal cavity.

[0026] Mint has the effects of dispelling wind and heat, clearing the head and throat, and can relieve symptoms such as wind-heat colds and sore throats.

[0027] Goose does not eat grass, it can dispel wind, open the orifices, detoxify and reduce swelling, and has a significant effect on nasal discomfort. It has the effects of dispersing wind and cold, opening the nasal orifices, relieving cough and detoxifying.

[0028] Schizonepeta can dispel wind and relieve exterior symptoms, clear rashes and relieve itching. It is suitable for various nasal inflammations and itching symptoms, and treat colds, fever, headaches, and sore throats.

[0029] Qianghuo can dispel wind and dampness, open up joints, and has a good effect on rheumatic nasal congestion.

[0030] Asarum, which is pungent and warm, can dispel wind and relieve pain, and helps relieve nasal pain.

[0031] Borneol has a cooling effect, invigorates the senses, relieves pain, and enhances the cooling feeling and comfort of the gel.

[0032] The invention adopts natural Chinese medicine, and according to the formula of monarch, minister, assistant and envoy in traditional Chinese medicine theory, goose grass and platycodon are monarch medicines, platycodon is used to clear the lung and eliminate phlegm, goose grass is used to eliminate inflammation and detoxify, and mainly eliminates phlegm and eliminates inflammation. The combination of the two is helpful to clear nasal secretions and relieve nasal inflammation; schizonepeta, angelica root and asarum are minister medicines, and all three have the effects of dispelling wind and relieving exterior symptoms, clearing nasal passages, dispelling wind and relieving itching, dispelling wind and removing dampness, and relieving exterior symptoms with pungent and warm properties, focusing on clearing visceral heat. Rhinitis and sinusitis are mostly caused by exogenous wind-cold in the early stage, which then turns into internal heat. Therefore, while eliminating phlegm and eliminating inflammation, the internal heat is cleared, and the monarch medicine is used to clear nasal secretions and relieve nasal inflammation. Combined use further enhances the overall therapeutic effect and the effect of unblocking the nasal cavity; magnolia and Xanthium sibiricum are adjuvants, which can dispel wind-cold and have good therapeutic effects on symptoms such as wind-cold headache and nasal congestion. Combined use can consolidate the effect of unblocking the nasal cavity; mint and borneol are guiding drugs, and the cooling sensation of mint and the invigorating effect of borneol complement each other, which can quickly relieve nasal congestion and nasal discomfort and improve the patient's comfort. At the same time, some patients may also have wind-heat attacking the surface, so adding mint to assist the adjuvant in dispersing wind-cold while dispersing wind-heat, and the formulas cooperate with each other and promote each other synergistically.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] The invention provides a gel for clearing the nasal cavity. The drugs of the invention are used in combination and cooperate with each other to eliminate phlegm, reduce inflammation and relieve the symptoms of patients, while dispelling wind and relieving exterior symptoms, clearing lung heat and dispersing wind and cold from the inside, thereby enhancing the therapeutic effect and avoiding recurrence, achieving the effect of treating both the symptoms and the root causes, strictly matching and reasonably formulating, achieving remarkable therapeutic effect, short clinical treatment cycle and high cure rate. DETAILED DESCRIPTION

[0035] The specific embodiments of the present invention are described in detail below, but it should be understood that the protection scope of the present invention is not limited by the specific embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work belong to the protection scope of the present invention. The experimental methods described in the embodiments of the present invention are conventional methods unless otherwise specified.

[0036] Example 1

[0037] A gel for clearing the nasal cavity is composed of the following raw materials in parts by weight: 1 part of magnolia, 1 part of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 2 parts of aconite, 2 parts of schizonepeta, 1 part of notopterygium wilfordii, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 20 parts of water.

[0038] A method for preparing a gel for clearing the nasal cavity comprises the following steps:

[0039] (1) Weighing an emulsifier, a thickener, a preservative, and an antimicrobial agent in a mass ratio of 1:1:1:1 and mixing them to obtain an auxiliary material;

[0040] (2) Weigh 1 part of magnolia, 1 part of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 2 parts of aconite, 2 parts of schizonepeta, 1 part of notopterygium, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 20 parts of water.

[0041] (3) The weighed Angelica dahurica, Magnolia officinalis, Xanthium sibiricum, Platycodon grandiflorum, Mentha arvense, Herba Capillaris, Schizonepeta tenuifolia, Notopterygium wilfordii, Asarum sieboldii and water were mixed and heated at 95° C. to obtain a Chinese herbal medicine mixture.

[0042] (4) Mix the weighed borneol, emulsifier, thickener, preservative, and antibacterial agent, and heat at 40° C. to obtain an auxiliary material mixture.

[0043] (5) The Chinese herbal medicine mixture obtained in step (3) and the auxiliary material mixture obtained in step (4) are mixed and heated at 65° C. to obtain the nasal cavity clearing gel.

[0044] Example 2

[0045] A gel for clearing the nasal cavity is composed of the following raw materials in parts by weight: 1 part of magnolia, 2 parts of Xanthium sibiricum, 2 parts of platycodon, 2 parts of mint, 3 parts of aconite, 3 parts of schizonepeta, 1 part of notopterygium, 1 part of asarum, 1 part of borneol, 3 parts of auxiliary materials and 30 parts of water.

[0046] A method for preparing a gel for clearing the nasal cavity comprises the following steps:

[0047] (1) Weighing an emulsifier, a thickener, a preservative, and an antimicrobial agent in a mass ratio of 1:1:1:1 and mixing them to obtain an auxiliary material;

[0048] (2) Weigh 1 part of magnolia, 2 parts of Xanthium sibiricum, 2 parts of platycodon, 2 parts of mint, 3 parts of aconite, 3 parts of schizonepeta, 1 part of notopterygium, 1 part of asarum, 1 part of borneol, 3 parts of auxiliary materials, and 30 parts of water.

[0049] (3) The weighed Angelica dahurica, Magnolia officinalis, Xanthium sibiricum, Platycodon grandiflorum, Mentha arvense, Herba Capillaris, Schizonepeta tenuifolia, Notopterygium wilfordii, Asarum sieboldii and water were mixed and heated at 80° C. to obtain a Chinese herbal medicine mixture.

[0050] (4) Mix the weighed borneol, emulsifier, thickener, preservative and antibacterial agent, and heat at 45° C. to obtain an auxiliary material mixture.

[0051] (5) The Chinese herbal medicine mixture obtained in step (3) and the auxiliary material mixture obtained in step (4) are mixed and heated at 80° C. to obtain the nasal cavity clearing gel.

[0052] Example 3

[0053] A gel for clearing the nasal cavity is composed of the following raw materials in parts by weight: 2 parts of magnolia, 1 part of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 3 parts of aconite, 3 parts of schizonepeta, 2 parts of notopterygium, 2 parts of asarum, 2 parts of borneol, 3 parts of auxiliary materials, and 30 parts of water.

[0054] A method for preparing a gel for clearing the nasal cavity comprises the following steps:

[0055] (1) Weighing an emulsifier, a thickener, a preservative, and an antimicrobial agent in a mass ratio of 1:1:1:1 and mixing them to obtain an auxiliary material;

[0056] (2) Weigh 2 parts of magnolia, 1 part of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 3 parts of aconite, 3 parts of schizonepeta, 2 parts of notopterygium, 2 parts of asarum, 2 parts of borneol, 3 parts of auxiliary materials, and 30 parts of water.

[0057] (3) Mix the weighed angelica dahurica, magnolia, Xanthium sibiricum, Platycodon grandiflorum, mint, Herba Capillaris, Schizonepeta tenuifolia, Notopterygium wilfordii, Asarum sieboldii and water, and heat at 85° C. to obtain a Chinese herbal medicine mixture.

[0058] (4) Mix the weighed borneol, emulsifier, thickener, preservative, and antibacterial agent, and heat at 50° C. to obtain an auxiliary material mixture.

[0059] (5) The Chinese herbal medicine mixture obtained in step (3) and the auxiliary material mixture obtained in step (4) are mixed and heated at 60° C. to obtain the nasal cavity clearing gel.

[0060] Example 4

[0061] A gel for clearing the nasal cavity is composed of the following raw materials in parts by weight: 1 part of magnolia, 1 part of Xanthium sibiricum, 1 part of platycodon, 1 part of mint, 3 parts of aconite, 2 parts of schizonepeta, 1 part of notopterygium wilfordii, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 30 parts of water.

[0062] A method for preparing a gel for clearing the nasal cavity comprises the following steps:

[0063] (1) Weighing an emulsifier, a thickener, a preservative, and an antimicrobial agent in a mass ratio of 1:1:1:1 and mixing them to obtain an auxiliary material;

[0064] (2) Weigh 1 part of magnolia, 1 part of Xanthium sibiricum, 1 part of platycodon, 1 part of mint, 3 parts of aconite, 2 parts of schizonepeta, 1 part of notopterygium, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 30 parts of water.

[0065] (3) Mix the weighed angelica dahurica, magnolia, Xanthium sibiricum, Platycodon grandiflorum, mint, Herba Capillaris, Schizonepeta tenuifolia, Notopterygium wilfordii, Asarum sieboldii and water, and heat at 90° C. to obtain a Chinese herbal medicine mixture.

[0066] (4) Mix the weighed borneol, emulsifier, thickener, preservative, and antibacterial agent, and heat at 40° C. to obtain an auxiliary material mixture.

[0067] (5) The Chinese herbal medicine mixture obtained in step (3) and the auxiliary material mixture obtained in step (4) are mixed and heated at 70° C. to obtain the nasal cavity clearing gel.

[0068] Comparative Example 1

[0069] The difference between Comparative Example 1 and Example 1 is that the weight portion of goose grass is 1 part, specifically as follows:

[0070] A gel for clearing the nasal cavity is composed of the following raw materials in parts by weight: 1 part of magnolia, 1 part of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 1 part of aconite, 2 parts of schizonepeta, 1 part of notopterygium wilfordii, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 20 parts of water.

[0071] A method for preparing a gel for clearing the nasal cavity comprises the following steps:

[0072] (1) Weighing an emulsifier, a thickener, a preservative, and an antimicrobial agent in a mass ratio of 1:1:1:1 and mixing them to obtain an auxiliary material;

[0073] (2) Weigh 1 part of magnolia, 1 part of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 1 part of ophiopogon, 2 parts of schizonepeta, 1 part of notopterygium, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 20 parts of water.

[0074] (3) The weighed Angelica dahurica, Magnolia officinalis, Xanthium sibiricum, Platycodon grandiflorum, Mentha arvense, Herba Capillaris, Schizonepeta tenuifolia, Notopterygium wilfordii, Asarum sieboldii and water were mixed and heated at 95° C. to obtain a Chinese herbal medicine mixture.

[0075] (4) Mix the weighed borneol, emulsifier, thickener, preservative, and antibacterial agent, and heat at 40° C. to obtain an auxiliary material mixture.

[0076] (5) The Chinese herbal medicine mixture obtained in step (3) and the auxiliary material mixture obtained in step (4) are mixed and heated at 65° C. to obtain the nasal cavity clearing gel.

[0077] Comparative Example 2

[0078] The difference between Comparative Example 2 and Example 1 is that the weight portion of goose grass is 4 parts, specifically as follows:

[0079] A gel for clearing the nasal cavity is composed of the following raw materials in parts by weight: 1 part of magnolia, 1 part of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 4 parts of ophiopogon, 2 parts of schizonepeta, 1 part of notopterygium wilfordii, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials and 20 parts of water.

[0080] A method for preparing a gel for clearing the nasal cavity comprises the following steps:

[0081] (1) Weighing an emulsifier, a thickener, a preservative, and an antimicrobial agent in a mass ratio of 1:1:1:1 and mixing them to obtain an auxiliary material;

[0082] (2) Weigh 1 part of magnolia, 1 part of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 4 parts of ophiopogon, 2 parts of schizonepeta, 1 part of notopterygium, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 20 parts of water.

[0083] (3) The weighed Angelica dahurica, Magnolia officinalis, Xanthium sibiricum, Platycodon grandiflorum, Mentha arvense, Herba Capillaris, Schizonepeta tenuifolia, Notopterygium wilfordii, Asarum sieboldii and water were mixed and heated at 95° C. to obtain a Chinese herbal medicine mixture.

[0084] (4) Mix the weighed borneol, emulsifier, thickener, preservative, and antibacterial agent, and heat at 40° C. to obtain an auxiliary material mixture.

[0085] (5) The Chinese herbal medicine mixture obtained in step (3) and the auxiliary material mixture obtained in step (4) are mixed and heated at 65° C. to obtain the nasal cavity clearing gel.

[0086] Comparative Example 3

[0087] The difference between Comparative Example 3 and Example 1 is that the weight portion of Nepeta tenuifolia is 1 part, specifically as follows:

[0088] A gel for clearing the nasal cavity is composed of the following raw materials in parts by weight: 1 part of magnolia, 1 part of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 1 part of schefflera, 1 part of schizonepeta, 1 part of notopterygium wilfordii, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 20 parts of water.

[0089] A method for preparing a gel for clearing the nasal cavity comprises the following steps:

[0090] (1) Weighing an emulsifier, a thickener, a preservative, and an antimicrobial agent in a mass ratio of 1:1:1:1 and mixing them to obtain an auxiliary material;

[0091] (2) Weigh 1 part of magnolia, 1 part of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 1 part of aconite, 1 part of schizonepeta, 1 part of notopterygium, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 20 parts of water.

[0092] (3) The weighed Angelica dahurica, Magnolia officinalis, Xanthium sibiricum, Platycodon grandiflorum, Mentha arvense, Herba Capillaris, Schizonepeta tenuifolia, Notopterygium wilfordii, Asarum sieboldii and water were mixed and heated at 95° C. to obtain a Chinese herbal medicine mixture.

[0093] (4) Mix the weighed borneol, emulsifier, thickener, preservative, and antibacterial agent, and heat at 40° C. to obtain an auxiliary material mixture.

[0094] (5) The Chinese herbal medicine mixture obtained in step (3) and the auxiliary material mixture obtained in step (4) are mixed and heated at 65° C. to obtain the nasal cavity clearing gel.

[0095] Comparative Example 4

[0096] The difference between Comparative Example 4 and Example 1 is that the weight parts of Nepeta tenuifolia are 4 parts, specifically as follows:

[0097] A gel for clearing the nasal cavity is composed of the following raw materials in parts by weight: 1 part of magnolia, 1 part of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 1 part of schefflera, 4 parts of schizonepeta, 1 part of notopterygium wilfordii, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 20 parts of water.

[0098] A method for preparing a gel for clearing the nasal cavity comprises the following steps:

[0099] (1) Weighing an emulsifier, a thickener, a preservative, and an antimicrobial agent in a mass ratio of 1:1:1:1 and mixing them to obtain an auxiliary material;

[0100] (2) Weigh 1 part of magnolia, 1 part of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 1 part of schefflera, 4 parts of schizonepeta, 1 part of notopterygium, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 20 parts of water.

[0101] (3) The weighed Angelica dahurica, Magnolia officinalis, Xanthium sibiricum, Platycodon grandiflorum, Mentha arvense, Herba Capillaris, Schizonepeta tenuifolia, Notopterygium wilfordii, Asarum sieboldii and water were mixed and heated at 95° C. to obtain a Chinese herbal medicine mixture.

[0102] (4) Mix the weighed borneol, emulsifier, thickener, preservative, and antibacterial agent, and heat at 40° C. to obtain an auxiliary material mixture.

[0103] (5) The Chinese herbal medicine mixture obtained in step (3) and the auxiliary material mixture obtained in step (4) are mixed and heated at 65° C. to obtain the nasal cavity clearing gel.

[0104] Comparative Example 5

[0105] The difference between Comparative Example 5 and Example 1 is that the weight portion of magnolia is 0.5 parts, and the weight portion of Xanthium sibiricum is 0.5 parts, specifically as follows:

[0106] A gel for clearing the nasal cavity is composed of the following raw materials in parts by weight: 0.5 parts of magnolia, 0.5 parts of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 1 part of schefflera, 2 parts of schizonepeta, 1 part of notopterygium wilfordii, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 20 parts of water.

[0107] A method for preparing a gel for clearing the nasal cavity comprises the following steps:

[0108] (1) Weighing an emulsifier, a thickener, a preservative, and an antimicrobial agent in a mass ratio of 1:1:1:1 and mixing them to obtain an auxiliary material;

[0109] (2) Weigh 0.5 parts of magnolia, 0.5 parts of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 1 part of ophiopogon, 2 parts of schizonepeta, 1 part of notopterygium, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 20 parts of water.

[0110] (3) The weighed Angelica dahurica, Magnolia officinalis, Xanthium sibiricum, Platycodon grandiflorum, Mentha arvense, Herba Capillaris, Schizonepeta tenuifolia, Notopterygium wilfordii, Asarum sieboldii and water were mixed and heated at 95° C. to obtain a Chinese herbal medicine mixture.

[0111] (4) Mix the weighed borneol, emulsifier, thickener, preservative, and antibacterial agent, and heat at 40° C. to obtain an auxiliary material mixture.

[0112] (5) The Chinese herbal medicine mixture obtained in step (3) and the auxiliary material mixture obtained in step (4) are mixed and heated at 65° C. to obtain the nasal cavity clearing gel.

[0113] Comparative Example 6

[0114] The difference between Comparative Example 6 and Example 1 is that the weight parts of magnolia floret are 3 parts, and the weight parts of Xanthium sibiricum are 3 parts, specifically as follows:

[0115] A gel for clearing the nasal cavity is composed of the following raw materials in parts by weight: 3 parts of magnolia, 3 parts of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 1 part of ophiopogon, 2 parts of schizonepeta, 1 part of notopterygium wilfordii, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 20 parts of water.

[0116] A method for preparing a gel for clearing the nasal cavity comprises the following steps:

[0117] (1) Weighing an emulsifier, a thickener, a preservative, and an antimicrobial agent in a mass ratio of 1:1:1:1 and mixing them to obtain an auxiliary material;

[0118] (2) Weigh 3 parts of magnolia, 3 parts of Xanthium sibiricum, 2 parts of platycodon, 1 part of mint, 1 part of aconite, 2 parts of schizonepeta, 1 part of notopterygium, 1 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 20 parts of water.

[0119] (3) The weighed Angelica dahurica, Magnolia officinalis, Xanthium sibiricum, Platycodon grandiflorum, Mentha arvense, Herba Capillaris, Schizonepeta tenuifolia, Notopterygium wilfordii, Asarum sieboldii and water were mixed and heated at 95° C. to obtain a Chinese herbal medicine mixture.

[0120] (4) Mix the weighed borneol, emulsifier, thickener, preservative and antibacterial agent, and heat at 40° C. to obtain an auxiliary material mixture.

[0121] (5) The Chinese herbal medicine mixture obtained in step (3) and the auxiliary material mixture obtained in step (4) are mixed and heated at 65° C. to obtain the nasal cavity clearing gel.

[0122] Comparative Example 7

[0123] The difference between Comparative Example 7 and Example 1 is that the weight portion of Platycodon grandiflorum is 3 parts, the weight portion of mint is 3 parts, the weight portion of Notopterygium wilfordii is 0.5 parts, and the weight portion of Asarum is 0.5 parts, as follows:

[0124] A gel for clearing the nasal cavity is composed of the following raw materials in parts by weight: 1 part of magnolia, 1 part of Xanthium sibiricum, 3 parts of platycodon, 3 parts of mint, 1 part of schefflera, 2 parts of schizonepeta, 0.5 part of notopterygium wilfordii, 0.5 part of asarum, 1 part of borneol, 2 parts of auxiliary materials and 20 parts of water.

[0125] A method for preparing a gel for clearing the nasal cavity comprises the following steps:

[0126] (1) Weighing an emulsifier, a thickener, a preservative, and an antimicrobial agent in a mass ratio of 1:1:1:1 and mixing them to obtain an auxiliary material;

[0127] (2) Weigh 1 part of magnolia, 1 part of Xanthium sibiricum, 3 parts of platycodon, 3 parts of mint, 1 part of ophiopogon, 2 parts of schizonepeta, 0.5 part of notopterygium, 0.5 part of asarum, 1 part of borneol, 2 parts of auxiliary materials, and 20 parts of water.

[0128] (3) The weighed Angelica dahurica, Magnolia officinalis, Xanthium sibiricum, Platycodon grandiflorum, Mentha arvense, Herba Capillaris, Schizonepeta tenuifolia, Notopterygium wilfordii, Asarum sieboldii and water were mixed and heated at 95° C. to obtain a Chinese herbal medicine mixture.

[0129] (4) Mix the weighed borneol, emulsifier, thickener, preservative, and antibacterial agent, and heat at 40° C. to obtain an auxiliary material mixture.

[0130] (5) The Chinese herbal medicine mixture obtained in step (3) and the auxiliary material mixture obtained in step (4) are mixed and heated at 65° C. to obtain the nasal cavity clearing gel.

[0131] Clinical efficacy trial

[0132] 1. Comparison of the effects of the gels of the embodiment and the comparative example

[0133] 1. General clinical data

[0134] There were 52 cases in this group, 24 in the treatment group and 28 in the control group. There were 22 males: 11 in the treatment group and 11 in the control group, and 30 females: 15 in the treatment group and 15 in the control group. The ages ranged from 21 to 52 years old, with an average age of 35 years old. The disease course ranged from 6 months to 10 years.

[0135] According to the classification of disease conditions: 24 cases of chronic rhinitis, 12 cases in the treatment group and 12 cases in the control group, 28 cases of allergic rhinitis, 14 cases in the treatment group and 14 cases in the control group. The main symptoms were nasal congestion, runny nose, sneezing, labored breathing, and some patients had headaches and confusion. No other treatment was done before treatment.

[0136] The treatment group was divided into 4 groups, each with 3 males and 3 females, for a total of 6 cases.

[0137] The control group was divided into 7 groups, each group had 2 males and 2 females, a total of 4 cases.

[0138] The effect statistics are the average effect of each group. The treatment effect is judged by the diagnostic symptoms in Table 2. The comparison results are shown in Table 1:

[0139] Table 1 Effect comparison

[0140]

[0141]

[0142]

[0143] 2. The nasal dredging gel prepared by the present invention was used to treat 50 cases of rhinitis, including 25 cases in the control group, and the efficacy and side effects were observed. The observation results are summarized as follows:

[0144] 1. General clinical data

[0145] There were 50 cases in this group, 25 in the treatment group and 25 in the control group. There were 20 males: 10 in the treatment group and 10 in the control group, and 30 females: 15 in the treatment group and 15 in the control group. The patients were aged 21 to 52 years old, with an average age of 35 years old. The disease course ranged from 6 months to 10 years.

[0146] According to the classification of disease conditions: 22 cases of chronic rhinitis, 11 cases in the treatment group and 11 cases in the control group, 28 cases of allergic rhinitis, 14 cases in the treatment group and 14 cases in the control group. The main symptoms were nasal congestion, runny nose, sneezing, labored breathing, and some patients had headaches and confusion. No other treatment was done before treatment.

[0147] 2. Selection of observation objects

[0148] (1) Disease diagnostic criteria: Chronic rhinitis and allergic rhinitis with clinical manifestations of nasal congestion, sneezing, and runny nose.

[0149] (2) Disease diagnosis symptom classification: see Table 2.

[0150] Table 2 Disease diagnosis symptom classification

[0151]

[0152] 3. Treatment options

[0153] (1) Number of cases observed and grouped: 25 cases in the treatment group and 25 cases in the control group, a total of 50 cases.

[0154] (2) Grouping: While respecting the patients' right to know, the patients were grouped according to the random number table.

[0155] (3) Experimental drug: the gel of Example 1. Control drug: Dibijing.

[0156] (4) Dosage: The treatment group used the product of the present invention, applying the gel to the nasal cavity with a cotton swab every 4 hours, 3 times a day. The control group used Dibijing.

[0157] (5) Treatment course: 3 to 20 days for both the treatment and control groups.

[0158] (6) Case source: All patients in the treatment group and the control group received outpatient treatment, but variable factors were controlled to ensure that patients could only use the product of the present invention and the control drug.

[0159] 4. Efficacy evaluation criteria

[0160] (1) Clinical control: A. Grade I: cured within 5 days; B. Grade II: cured within 10-15 days; C. Grade III: cured within 16-20 days without any symptoms; D. More than 90% of the disease symptoms disappear.

[0161] (2) Markedly effective: Subjective symptoms basically disappeared, with no clinical manifestations such as nasal congestion, sneezing, and runny nose, and no recurrence was observed for more than 2 months after the end of treatment.

[0162] (3) Effective: The patient's subjective symptoms were alleviated, with occasional clinical manifestations such as nasal congestion, sneezing, and runny nose, but the disease did not recur 2 months after the end of treatment.

[0163] (4) Ineffective: Symptoms and disease conditions remain unchanged from before treatment.

[0164] 5. Observation indicators

[0165] Efficacy observation: A. Changes in nasal mucosal symptoms: relief, disappearance, aggravation, etc.; B. Changes in nasal mucosal swelling: relief, disappearance, aggravation, etc.; C. Nasal mucosal healing: complete healing, partial healing, non-healing.

[0166] 6. Treatment results

[0167] (1) Comparison of clinical efficacy between the two groups is shown in Table 3.

[0168] Table 3 Clinical efficacy results of the two groups

[0169] Grouping Number of cases Clinical control Significant effect efficient invalid Effectiveness (%) Treatment Group 25 19 2 3 1 96 Control group 25 15 1 2 7 72

[0170] The total effective rate was 96% in the treatment group and 72% in the control group, and the difference was statistically significant (P<0.01).

[0171] (2) Comparison of the main symptoms and the number of cases in which nasal mucosal swelling disappeared before and after treatment between the two groups is shown in Table 4.

[0172] Table 4 Comparison of symptoms and disappearance of nasal mucosal swelling before and after treatment

[0173]

[0174] There were significant differences in all other aspects except headache between the two groups, indicating that the treatment group was significantly better than the control group.

[0175] The results show that the product of the present invention is significantly better than the control group's nose drops in the treatment of simple rhinitis and allergic rhinitis, mainly in terms of the improvement of various symptoms of rhinitis. It has a definite effect, no toxic side effects, and is suitable for all patients.

[0176] It should be noted that when the claims of the present invention involve numerical ranges, it should be understood that the two endpoints of each numerical range and any numerical value between the two endpoints can be selected. In order to avoid redundancy, the present invention describes a preferred embodiment.

[0177] Although the preferred embodiments of the present invention have been described, those skilled in the art may make other changes and modifications to these embodiments once they have learned the basic creative concept. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications that fall within the scope of the present invention.

[0178] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. A gel for clearing the nasal cavity, characterized in that: The invention is prepared from the following raw materials in parts by weight: 1-2 parts of magnolia, 1-2 parts of Xanthium sibiricum, 1-2 parts of platycodon, 1-2 parts of mint, 2-3 parts of ophiopogon, 2-3 parts of schizonepeta, 1-2 parts of notopterygium wilfordii, 1-2 parts of asarum, 1-2 parts of borneol, 2-3 parts of auxiliary materials and 20-30 parts of water.

2. A gel for clearing the nasal cavity according to claim 1, characterized in that: The auxiliary material is a mixture of emulsifier, thickener, preservative and antibacterial agent; The mass ratio of the emulsifier, thickener, preservative and antibacterial agent is 1-2:1-2:1-2:1-2.

3. A gel for clearing the nasal cavity according to claim 2, characterized in that: The emulsifier is any one of Poloxamer 188, Tween 20 and Tween 80.

4. The gel for clearing the nasal cavity according to claim 2, characterized in that: The thickener is any one of cationic guar gum, methyl cellulose, hydroxypropyl methyl cellulose and hyaluronic acid.

5. The gel for clearing the nasal cavity according to claim 2, characterized in that: The preservative is any one of p-hydroxybenzoic acid esters, benzalkonium chloride and chlorobutanol.

6. The gel for clearing the nasal cavity according to claim 2, characterized in that: The antibacterial agent is nano silver.

7. A method for preparing the gel for clearing the nasal cavity according to claim 1, characterized in that: The following steps are involved: Weigh the emulsifier, thickener, preservative and antibacterial agent in a mass ratio of 1-2:1-2:1-2:1-2 to obtain an auxiliary material; Weigh 1-2 parts of magnolia, 1-2 parts of Xanthium sibiricum, 1-2 parts of platycodon, 1-2 parts of mint, 2-3 parts of schefflera, 2-3 parts of schizonepeta, 1-2 parts of notopterygium, 1-2 parts of asarum, 1-2 parts of borneol, 2-3 parts of auxiliary materials, and 20-30 parts of water; The weighed Angelica dahurica, Magnolia officinalis, Xanthium sibiricum, Platycodon grandiflorum, Mentha arvense, Herba Schisandrae Chinensis, Nepeta tenuifolia, Notopterygium wilfordii, Asarum sieboldii and water are mixed and heated for the first time to obtain a Chinese herbal medicine mixture; The weighed borneol and auxiliary materials are mixed evenly, and heated for a second time to obtain an auxiliary material mixture; The Chinese herbal medicine mixture and the auxiliary material mixture are mixed evenly, and heated for a third time to obtain the nasal cavity clearing gel; Among them, the temperature of the first heating is higher than the temperature of the third heating, and the temperature of the third heating is higher than the temperature of the second heating.

8. The method for preparing the gel for clearing the nasal cavity according to claim 7, characterized in that: The temperature of the first heating is 80°C to 95°C.

9. The method for preparing the gel for clearing the nasal cavity according to claim 7, characterized in that: The temperature of the second heating is 40°C to 50°C.

10. The method for preparing the gel for clearing the nasal cavity according to claim 7, characterized in that: The temperature of the third heating is 60°C to 80°C.

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