Formula for treating liver and gallbladder damp-heat syndrome of acute pancreatitis and preparation method thereof

Abstract

The invention provides a formula for treating liver and gallbladder damp-heat syndrome of acute pancreatitis and a preparation method of the formula. The formula comprises 15g of radix bupleuri, 15g of radix paeoniae rubra, 15g of fructus aurantii immaturus, 15g of cortex magnoliae officinalis, 10g of raw rhubarb, 10g of mirabilite, 10g of radix scutellariae, 10g of rhizoma pinelliae preparata and 15g of rhizoma corydalis. Scutellaria baicalensis has the effects of clearing heat and drying dampness, and can effectively eliminate dampness and heat of liver and gallbladder. The mangnolia officinalis is used for eliminating dampness and dissolving phlegm and is beneficial to removing damp-heat pathogens in The raw rhubarb purges and attacks food retention, and the purgation effect of the rhubarb can be enhanced after the rhubarb purges, so that damp-heat evil is discharged through excrement, and the effect of purgation is achieved. Meanwhile, the rheum officinale also has the effects of clearing heat, purging fire, cooling blood and detoxifying, and is beneficial to relieving inflammatory response and relieving pain. Mirabilite can purge and relax bowels, clear fire and subdue swelling. After blending, the purgation effect of the rhubarb can be enhanced, and the rhubarb and the rhubarb jointly achieve the effects of purging fu-organs, removing heat and relieving pain.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine formulas, and in particular to a formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis and a preparation method thereof. Background Art

[0002] Acute pancreatitis is a common acute abdomen, and liver-gallbladder damp-heat syndrome is one of its common TCM syndromes. In the treatment of acute pancreatitis, finding an effective treatment method has always been the focus of medical attention. Chinese invention patent application number CN201510880076.2 discloses a Chinese medicine formula for treating acute pancreatitis.

[0003] However, the existing Chinese medicine formulas for pancreatitis have some shortcomings during use and still need to be improved. The existing Chinese medicine formulas are often relatively simple and may focus on one aspect of treatment, such as simple anti-inflammatory treatment or analgesic treatment, and fail to comprehensively consider multiple aspects such as clearing heat and dampness, relieving bowel pain, and soothing the liver and regulating qi, resulting in an incomplete treatment effect.

[0004] Existing Chinese medicine formulas are not thorough enough in removing damp-heat evil: Some treatment methods are not effective in removing damp-heat evil in the body, and cannot effectively relieve the symptoms related to liver and gallbladder damp-heat syndrome, such as jaundice, fever, and bitter taste in the mouth. Gastrointestinal dysfunction is one of the common problems for patients with acute pancreatitis. In the existing Chinese medicine formulas, the measures for eliminating gastrointestinal stagnation and improving gastrointestinal function are not perfect, and it is difficult to effectively relieve abdominal distension and abdominal pain symptoms.

[0005] Acute pancreatitis is often accompanied by severe abdominal pain, and existing treatment methods may be insufficient in terms of pain relief, and cannot quickly and effectively relieve the patient's pain, affecting the patient's quality of life and treatment compliance. The normal drainage function of the liver and gallbladder in the existing Chinese medicine formula is crucial for the recovery of acute pancreatitis, but there are relatively few measures in the prior art to relieve the stagnation of liver and gallbladder qi and restore liver and gallbladder function. Therefore, we have made improvements to this and proposed a formula for liver and gallbladder damp-heat syndrome of acute pancreatitis and its preparation method. Summary of the invention

[0006] The purpose of the present invention is to solve the problems raised by the existing background technology. In order to achieve the above invention purpose, the present invention provides the following technical scheme: a formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis, the formula ingredients comprising: bupleurum, red peony root, immature bitter orange, magnolia bark, raw rhubarb, mirabilite, scutellaria, pinellia tuber, and corydalis.

[0007] As a preferred technical solution of the present invention, the following ingredients are used: 15g of bupleurum, 15g of red peony root, 15g of immature bitter orange, 15g of Magnolia officinalis, 10g of raw rhubarb (added later), 10g of Glauber's salt (mixed), 10g of scutellaria, 10g of pinellia, and 15g of Corydalis.

[0008] A method for preparing a formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis, comprising the following steps: Step 1. Preparing materials: accurately weighing 15g of bupleurum root, 15g of red peony root, 15g of immature bitter orange, 15g of magnolia bark, 10g of raw rhubarb, 10g of sodium sulfate, 10g of scutellaria baicalensis, 10g of pinellia tuber, and 15g of corydalis according to the formula; preparing a casserole and a strainer;

[0009] Step 2. Medicinal material processing:

[0010] Rinse Bupleurum, Red Peony Root, Immature Citrus Aurantium, Magnolia Officinalis, Scutellaria Baicalensis, Pinellia Terrestris, and Corydalis with clean water to remove impurities on the surface;

[0011] Step 3. Soak the herbs:

[0012] Put the processed bupleurum, red peony root, immature bitter orange, Magnolia officinalis, scutellaria, pinellia tuber, and corydalis into a casserole, add appropriate amount of water, the amount of water should be 2-3 cm above the medicinal materials;

[0013] Soak for 30 minutes to allow the herbs to fully absorb water, which is conducive to the extraction of effective ingredients;

[0014] Step 4. Decoction of herbs:

[0015] After soaking, place the casserole on the stovetop and bring the water to a boil over high heat;

[0016] After the water boils, immediately turn the heat to low and keep the liquid at a slight boil for decocting.

[0017] Simmer over low heat for 30 minutes, stirring occasionally to ensure that the herbs are heated evenly and the ingredients are fully extracted.

[0018] Step 5. Add raw rhubarb:

[0019] After 30 minutes, add the raw rhubarb to the casserole;

[0020] Continue to simmer for 5-10 minutes, keeping the heat low.

[0021] Step 6. Filter out the drug solution:

[0022] Use a fine strainer to filter out the liquid medicine and pour it into a clean container;

[0023] Step 7. Add Glauber's Salt:

[0024] Add the Glauber's salt into the filtered medicinal solution and stir evenly to allow the Glauber's salt to fully dissolve.

[0025] As a preferred technical solution of the present invention, step 2. during the treatment of medicinal materials; for rinsing medicinal materials: put bupleurum, red peony root, immature bitter orange, Magnolia officinalis, Scutellaria baicalensis, Pinellia ternata, and Corydalis yanhusuo into different containers respectively; rinse the medicinal materials slowly with clean water; the rinsing time is 1-2 minutes; the rinsed water is filtered through a sieve; the density of the sieve is 200-300 mesh.

[0026] As a preferred technical solution of the present invention, step 3. soaking the medicinal materials: gently stir the medicinal materials every 10 minutes during the soaking time of 30 minutes; the temperature of the soaking water is 20°C-26°C.

[0027] As a preferred technical solution of the present invention, step 4. decocting the medicinal materials: turn on the stove; adjust the fire to high heat; make the water in the pot boil rapidly; when the water temperature reaches 100°C; the water starts to boil; at this time, record the time;

[0028] After the water boils, immediately turn the heat to low to keep the medicinal liquid in a slightly boiling state. The temperature of the medicinal liquid should be maintained between 90-95℃. During the decoction process, use a stirring tool to gently stir the medicinal liquid every 5 minutes at a stirring speed of 30-40 revolutions per minute.

[0029] As a preferred technical solution of the present invention, step 5. adding raw rhubarb: keep decocting on low heat for 5-10 minutes; start timing from the time when the raw rhubarb is added; use a timer to time; during the decocting process; use a stirring tool to gently stir the medicinal liquid every 2-3 minutes.

[0030] As the preferred technical scheme of the present invention, step 6. filtering out the medicine liquid: the whole process of filtering out the medicine liquid is different according to the amount of the medicine liquid; the filtration time is 8-15 minutes; the temperature of the filtered medicine liquid is between 70-80°C; as the filtration process proceeds; the temperature gradually decreases; the filtration stirring speed is 15-20 revolutions per minute; every 1-2 minutes; gently stir the medicine liquid with clean chopsticks or a stirring rod; the stirring speed is 15-20 revolutions per minute; to promote the filtration of the medicine liquid; and at the same time reduce the possibility of filter clogging.

[0031] As a preferred technical solution of the present invention, step 7. adding Glauber's salt: slowly add Glauber's salt to the filtered medicinal solution; stir while adding; the stirring speed is 30-40 revolutions per minute; so that the Glauber's salt is fully dissolved; the process of adding Glauber's salt takes 5-10 minutes; the temperature of the medicinal solution is between 40-50°C; the stirring speed of adding Glauber's salt is: 30-40 revolutions per minute.

[0032] A formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis is used by using a formula of 15g of bupleurum, 15g of red peony root, 15g of immature bitter orange, 15g of magnolia bark, 10g of raw rhubarb (added later), 10g of sodium sulfate (mixed), 10g of scutellaria, 10g of pinellia tuber, and 15g of corydalis in a traditional Chinese medicine Tongjiangqingpi decoction.

[0033] Compared with the prior art, the invention has the following beneficial effects: In the scheme of the invention: The invention clears dampness and heat: Scutellaria baicalensis has the effect of clearing heat and drying dampness, and can effectively clear dampness and heat in the liver and gallbladder. Magnolia officinalis dries dampness and eliminates phlegm, which helps to eliminate dampness and heat in the body.

[0034] The present invention has the effect of clearing the bowels and relieving pain: raw rhubarb has the effect of purging and attacking accumulation, and the purgative effect can be enhanced after adding it, so that the damp-heat evil can be discharged through the stool, achieving the effect of clearing the bowels. At the same time, rhubarb also has the effects of clearing heat and purging fire, cooling blood and detoxifying, which helps to reduce inflammatory reactions and relieve pain. Glauber's salt has the effect of purging and relieving constipation, moistening dryness and softening hard masses, clearing fire and reducing swelling. After being mixed and transformed, the purgative effect of rhubarb can be enhanced, and they can play the role of clearing the bowels and relieving heat and relieving pain together. Citrus aurantium can break up qi and eliminate accumulation, resolve phlegm and relieve lumps, and can improve gastrointestinal stagnation, promote the unobstructed flow of bowel qi, and relieve symptoms of abdominal distension and abdominal pain.

[0035] The present invention soothes the liver and regulates qi: Bupleurum has the effects of reconciling the exterior and the interior, soothing the liver and relieving depression, can relieve the stagnation of qi in the liver and gallbladder, and restore the normal function of the liver and gallbladder to release qi.

[0036] The invention promotes blood circulation and relieves pain: red peony root clears away heat and cools blood, dissipates blood stasis and relieves pain, and can relieve blood heat symptoms caused by liver and gallbladder damp-heat syndrome and pain caused by pancreatitis. Corydalis yanhusuo promotes blood circulation, promotes qi and relieves pain, and has a good effect on relieving abdominal pain caused by acute pancreatitis.

[0037] The invention can soothe the stomach and reduce adverse reactions: it can clear away dampness and resolve phlegm, reduce adverse reactions and stop vomiting, eliminate lumps and resolve stagnation, relieve symptoms of nausea, vomiting and stomach discomfort, and regulate gastrointestinal function. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] Figure 1 A formula diagram provided by the present invention;

[0039] Figure 2 A flow chart of the method provided by the present invention;

[0040] Figure 3 This is a table of experimental data provided by the present invention. DETAILED DESCRIPTION

[0041] To make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be described clearly and completely in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them.

[0042] Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the claimed invention, but merely represents some embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. It should be noted that the embodiments of the present invention and the features and technical solutions in the embodiments can be combined with each other without conflict. It should be noted that similar numbers and letters represent similar items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0043] Example 1: Please refer to Figure 1 , a formula for treating liver-gallbladder damp-heat syndrome in acute pancreatitis, the ingredients of which include: bupleurum, red peony root, immature bitter orange, magnolia bark, raw rhubarb, sodium sulfate, scutellaria, pinellia ternata, and yanhusuo.

[0044] Take the following ingredients in the formula: 15g of Bupleurum, 15g of Red Peony Root, 15g of Citrus Aurantium, 15g of Magnolia Officinalis, 10g of Raw Rhubarb (added later), 10g of Glauber's Salt (mixed), 10g of Scutellaria Baicalensis, 10g of Pinellia Terrestris, and 15g of Corydalis.

[0045] The medicinal properties of the formula for acute pancreatitis with liver and gallbladder damp-heat syndrome:

[0046] Bupleurum: It has the functions of reconciling the exterior and interior, soothing the liver and relieving depression, and raising yang and lifting the sunken. In this formula, Bupleurum can relieve the stagnation of qi in the liver and gallbladder, and help restore the normal function of the liver and gallbladder.

[0047] Red peony root: clears heat and cools blood, dissipates blood stasis and relieves pain. Red peony root can clear heat and cool blood, relieve blood heat symptoms caused by liver and gallbladder dampness and heat, and its effect of dissipating blood stasis and relieving pain can relieve pain caused by pancreatic inflammation.

[0048] Zhishi: breaks up qi and eliminates stagnation, resolves phlegm and relieves abdominal distension. Zhishi can promote qi and eliminate stagnation, eliminate gastrointestinal stagnation, improve gastrointestinal function, and relieve abdominal distension symptoms.

[0049] Magnolia officinalis: dries up dampness and eliminates phlegm, relieves gas and relieves fullness. Magnolia officinalis has the effect of drying up dampness and can clear away dampness and heat in the body, while also relieving gas and relieve fullness, alleviating the symptoms of abdominal distension.

[0050] Raw rhubarb: It can purge and attack accumulation, clear away heat and fire, cool blood and detoxify, and remove blood stasis and promote menstruation. Taking raw rhubarb after the meal can enhance its purgative effect, so that dampness and heat can be discharged from the stool, achieving the purpose of clearing heat and fire, and detoxifying. At the same time, the blood stasis and menstruation-promoting effect of rhubarb can also help improve the blood circulation of the pancreas and promote the disappearance of inflammation.

[0051] Glauber's Salt: It has laxative effect, moisturizes dryness and softens hard masses, clears away heat and reduces swelling. After being diluted, Glauber's Salt can enhance the laxative effect of rhubarb, and together they can clear the bowels and release heat, clearing away the damp heat in the body.

[0052] Scutellaria baicalensis: clears heat and dries dampness, purges fire and detoxifies, stops bleeding, and stabilizes pregnancy. Scutellaria baicalensis has a strong effect of clearing heat and dries dampness, can clear dampness and heat in the liver and gallbladder, purge fire and detoxify, and reduce inflammatory reactions.

[0053] Qing Banxia: Drying dampness and resolving phlegm, relieving adverse reactions and stopping vomiting, and dissolving lumps and knots. Qing Banxia can dry dampness and resolve phlegm, harmonize the stomach and reduce adverse reactions, relieve symptoms of nausea and vomiting, and at the same time help eliminate phlegm and dampness stagnation.

[0054] Yuanhu: promote blood circulation, promote qi circulation, and relieve pain. Yuanhu has a good effect of promoting qi circulation and relieving pain, and can relieve abdominal pain symptoms caused by acute pancreatitis.

[0055] Example 2: A method for preparing a formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis, please refer to Figure 2 , comprising the following steps: Step 1. Prepare the materials: accurately weigh 15g of Bupleurum Root, 15g of Red Peony Root, 15g of Citrus Aurantium, 15g of Magnolia Officinalis, 10g of Raw Rhubarb, 10g of Sodium Sulfate, 10g of Scutellaria Baicalensis, 10g of Pinellia Tuber, and 15g of Corydalis according to the formula; prepare a casserole and a strainer;

[0056] Step 2. Medicinal material processing:

[0057] Rinse Bupleurum, Red Peony Root, Immature Citrus Aurantium, Magnolia Officinalis, Scutellaria Baicalensis, Pinellia Terrestris, and Corydalis with clean water to remove impurities on the surface;

[0058] Step 3. Soak the herbs:

[0059] Put the processed bupleurum, red peony root, immature bitter orange, Magnolia officinalis, scutellaria, pinellia tuber, and corydalis into a casserole, add appropriate amount of water, the amount of water should be 2-3 cm above the medicinal materials;

[0060] Soak for 30 minutes to allow the herbs to fully absorb water, which is conducive to the extraction of effective ingredients;

[0061] Step 4. Decoction of herbs:

[0062] After soaking, place the casserole on the stovetop and bring the water to a boil over high heat;

[0063] After the water boils, immediately turn the heat to low and keep the liquid at a slight boil for decocting.

[0064] Simmer over low heat for 30 minutes, stirring occasionally to ensure that the herbs are heated evenly and the ingredients are fully extracted.

[0065] Step 5. Add raw rhubarb:

[0066] After 30 minutes, add the raw rhubarb to the casserole;

[0067] Continue to simmer for 5-10 minutes, keeping the heat low.

[0068] Step 6. Filter out the drug solution:

[0069] Use a fine strainer to filter out the liquid medicine and pour it into a clean container;

[0070] Step 7. Add Glauber's Salt:

[0071] Add the Glauber's salt into the filtered medicinal solution and stir evenly to allow the Glauber's salt to fully dissolve.

[0072] Step 2. During the treatment of medicinal materials; for flushing medicinal materials: put Bupleurum, Red Peony Root, Immature Citrus aurantium, Magnolia officinalis, Scutellaria baicalensis, Pinellia ternata, and Corydalis yanhusuo into different containers respectively; slowly rinse the medicinal materials with clean water; the rinsing time is 1-2 minutes; the rinsed water is filtered through a sieve; the density of the sieve is 200-300 mesh.

[0073] Step 3. Soak the herbs: Gently stir the herbs every 10 minutes during the 30-minute soaking process; the temperature of the soaking water should be 20℃-26℃.

[0074] Step 4. Boil the herbs: Turn on the stove and turn the heat to high. Let the water in the pot boil rapidly. When the water temperature reaches 100℃, the water starts to boil. Record the time.

[0075] After the water boils, immediately turn the heat to low to keep the medicinal liquid in a slightly boiling state. The temperature of the medicinal liquid should be maintained between 90-95℃. During the decoction process, use a stirring tool to gently stir the medicinal liquid every 5 minutes at a stirring speed of 30-40 revolutions per minute.

[0076] Step 5. Add raw rhubarb: keep simmering over low heat for 5-10 minutes; start timing from the time the raw rhubarb is added; use a timer; during the simmering process; use a stirring tool to gently stir the liquid medicine every 2-3 minutes.

[0077] Step 6. Filter out the medicine liquid: The whole process of filtering out the medicine liquid depends on the amount of medicine liquid; the filtration time is 8-15 minutes; the temperature of the filtered medicine liquid is between 70-80℃; as the filtration process proceeds, the temperature gradually decreases; filtration stirring speed: 15-20 revolutions per minute; every 1-2 minutes, use clean chopsticks or a stirring rod to gently stir the medicine liquid at a stirring speed of 15-20 revolutions per minute to promote the filtration of the medicine liquid and reduce the possibility of filter clogging.

[0078] Step 7. Adding the Glauber's salt: slowly add the Glauber's salt into the filtered medicinal solution; stir while adding; the stirring speed is 30-40 revolutions per minute; so that the Glauber's salt is fully dissolved; the process of adding the Glauber's salt takes 5-10 minutes; the temperature of the medicinal solution is between 40-50℃; the stirring speed of adding the Glauber's salt is: 30-40 revolutions per minute.

[0079] A formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis is used by using a formula of 15g of bupleurum, 15g of red peony root, 15g of immature bitter orange, 15g of magnolia bark, 10g of raw rhubarb (added later), 10g of sodium sulfate (mixed), 10g of scutellaria, 10g of pinellia tuber, and 15g of corydalis in a traditional Chinese medicine Tongjiangqingpi decoction.

[0080] Example 3: A method for preparing a formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis: 1. Prepare materials:

[0081] Accurately weigh 15g of Bupleurum, 15g of Red Peony Root, 15g of Citrus Aurantium, 15g of Magnolia Officinalis, 10g of Raw Rhubarb, 10g of Sodium Sulfate, 10g of Scutellaria Baicalensis, 10g of Pinellia Ternate, and 15g of Corydalis.

[0082] Prepare a casserole dish and a strainer.

[0083] 2. Medicinal material processing:

[0084] Put bupleurum, red peony root, immature bitter orange, Magnolia officinalis, Scutellaria baicalensis, Pinellia ternata and Corydalis into different containers respectively.

[0085] Rinse the herbs slowly with clean water for 1-2 minutes.

[0086] The rinsed water is filtered through a 200-300 mesh screen to remove surface impurities.

[0087] 3. Soaking herbs:

[0088] Put the processed bupleurum, red peony root, immature bitter orange, Magnolia officinalis, Scutellaria baicalensis, Pinellia ternata and Corydalis yanhusuo into a casserole and add appropriate amount of water. The amount of water should be enough to cover the medicinal materials by 2-3 cm.

[0089] Soak for 30 minutes, the soaking water temperature should be 20℃-26℃, and stir the herbs gently every 10 minutes.

[0090] 4. Decoction of herbs:

[0091] Turn on the stove and turn the heat to high to make the water in the pot boil quickly. When the water temperature reaches 100℃, the water begins to boil and record the time.

[0092] After the water boils, immediately turn the heat to low to keep the medicine liquid in a slightly boiling state. The temperature of the medicine liquid should be maintained between 90-95℃.

[0093] During the decoction process, use a stirring tool to gently stir the liquid medicine every 5 minutes at a speed of 30-40 revolutions per minute. Decoction over low heat for 30 minutes.

[0094] 5. Add raw rhubarb:

[0095] After 30 minutes, add the raw rhubarb to the casserole.

[0096] Continue to simmer for 5-10 minutes on low heat, starting from the time the raw rhubarb is added, using a timer. During the simmering process, use a stirring tool to gently stir the liquid medicine every 2-3 minutes.

[0097] 6. Filter out the liquid medicine:

[0098] Filter the liquid through a fine strainer and pour into a clean container.

[0099] The entire process of filtering out the liquid medicine takes 8-15 minutes depending on the amount of liquid medicine, and the temperature of the filtered liquid medicine is between 70-80° C. As the filtering process proceeds, the temperature gradually decreases.

[0100] The filtering stirring speed is 15-20 revolutions per minute. Every 1-2 minutes, use clean chopsticks or a stirring rod to gently stir the medicine solution at a stirring speed of 15-20 revolutions per minute to promote the filtration of the medicine solution and reduce the possibility of filter clogging.

[0101] 7. Add Glauber's Salt:

[0102] Slowly add the Glauber's salt into the filtered medicinal solution, stirring while adding, at a stirring speed of 30-40 revolutions per minute to allow the Glauber's salt to fully dissolve.

[0103] The process of adding Glauber's salt takes 5-10 minutes, and the temperature of the liquid is between 40-50℃.

[0104] 1. During the medicinal material processing, the rinse water is filtered through a 200-300 mesh screen to effectively remove impurities on the surface of the medicinal materials, providing a good foundation for the subsequent decoction process.

[0105] 2. When soaking medicinal materials, control the soaking time to 30 minutes, the water temperature should be between 20℃-26℃, and stir gently every 10 minutes to allow the medicinal materials to fully absorb water, which is conducive to the decoction of effective ingredients.

[0106] 3. When decocting the medicinal materials, first boil them over high heat, then use low heat to maintain a slight boiling state of the medicinal liquid. The temperature should be controlled between 90-95°C, and stir every 5 minutes to ensure that the medicinal liquid is heated evenly and the effective ingredients can be fully released.

[0107] 4. After adding the raw rhubarb, continue to simmer on low heat for 5-10 minutes, stirring every 2-3 minutes to ensure that the effective ingredients of the raw rhubarb are fully integrated into the medicine.

[0108] 5. When filtering out the liquid medicine, the filtration time is 8-15 minutes, and the liquid medicine temperature is between 70-80℃. Through proper stirring, the filtration efficiency is improved and the possibility of filter clogging is reduced.

[0109] 6. When adding the Glauber's salt, control the liquid temperature between 40-50°C and the stirring speed at 30-40 rpm to fully dissolve the Glauber's salt and ensure the uniformity of the liquid.

[0110] According to the established preparation method, the formula liquid medicine for acute pancreatitis with liver and gallbladder damp-heat syndrome was successfully prepared. During the experiment, the key parameters of each step were strictly controlled to ensure the quality and efficacy of the liquid medicine.

[0111] Experimental example:

[0112] Experimental study on the preparation of a formula for treating liver-gallbladder damp-heat syndrome in acute pancreatitis

[0113] Experimental purpose: To prepare a formula for liver and gallbladder damp-heat syndrome for acute pancreatitis according to a specific preparation method, and to analyze the data during the experiment to verify the feasibility and effectiveness of the preparation method of the formula.

[0114] Experimental Materials:

[0115] 15g of Bupleurum, 15g of Red Peony Root, 15g of Citrus Aurantium, 15g of Magnolia Officinalis, 10g of Raw Rhubarb, 10g of Glauber's Salt, 10g of Scutellaria Baicalensis, 10g of Pinellia Terrestris, 15g of Corydalis; 1 casserole; 1 strainer

[0116] Experimental steps and data recording:

[0117] 1. Medicinal material processing:

[0118] Put bupleurum, red peony root, immature bitter orange, Magnolia officinalis, Scutellaria baicalensis, Pinellia ternata and Corydalis into different containers respectively.

[0119] Rinse the herbs slowly with clean water for 1.5 minutes.

[0120] The rinsed water was filtered through a 250-mesh screen.

[0121] 2. Soaking herbs:

[0122] Put the processed bupleurum, red peony root, immature bitter orange, Magnolia officinalis, Scutellaria baicalensis, Pinellia ternata and Corydalis yanhusuo into a casserole and add appropriate amount of water. The amount of water should be enough to cover the medicinal materials by 2.5 cm.

[0123] The temperature of the soaking water is 23℃, the soaking time is 30 minutes, and the medicinal materials are gently stirred every 10 minutes.

[0124] 3. Decoction of herbs:

[0125] Turn on the stove and turn the heat to high to make the water in the pot boil quickly. When the water temperature reaches 100℃, the water begins to boil and record the time.

[0126] After the water boils, immediately turn the heat to low to keep the liquid medicine at a slight boil and maintain the temperature of the liquid medicine at about 92°C. During the decoction process, use a stirring tool to gently stir the liquid medicine every 5 minutes at a stirring speed of 35 revolutions per minute. Decoction over low heat for 30 minutes.

[0127] 4. Add raw rhubarb:

[0128] After 30 minutes, add the raw rhubarb to the casserole.

[0129] Continue to simmer for 8 minutes on low heat, starting from the time the raw rhubarb is added, using a timer. During the simmering process, use a stirring tool to gently stir the liquid medicine every 2.5 minutes.

[0130] 5. Filter out the liquid medicine:

[0131] Use a fine filter to filter out the liquid medicine and pour it into a clean container. The entire filtering process takes 12 minutes depending on the amount of liquid medicine. The temperature of the filtered liquid medicine is around 75°C. As the filtering process proceeds, the temperature gradually decreases.

[0132] The filtering stirring speed is 18 revolutions per minute. Every 1.5 minutes, use clean chopsticks or a stirring rod to gently stir the medicine solution at a stirring speed of 18 revolutions per minute to promote the filtration of the medicine solution and reduce the possibility of filter clogging.

[0133] 6. Add Glauber's Salt:

[0134] Slowly add the Glauber's salt into the filtered medicinal solution, stirring at a speed of 35 revolutions per minute to fully dissolve the Glauber's salt.

[0135] The process of adding Glauber's salt takes 8 minutes, and the temperature of the liquid is around 45°C.

[0136] Experimental data

[0137]

[0138]

[0139] Data analysis

[0140] 1. Symptom severity:

[0141] The difference in symptom severity scores before and after treatment was calculated to assess symptom improvement.

[0142] The symptom improvement degree of patient 1 was 8-3=5 points.

[0143] The symptom improvement of all patients was averaged to obtain the mean symptom improvement.

[0144] 2. Amylase Levels:

[0145] The difference in amylase levels before and after treatment was calculated to evaluate the reduction of amylase.

[0146] Patient 1's amylase reduction was 500-150=350 U / L.

[0147] The amylase reduction levels of all patients were averaged to obtain the mean amylase reduction level.

[0148] 3. Lipase Levels:

[0149] The difference in lipase levels before and after treatment was calculated to evaluate the reduction of lipase.

[0150] The degree of lipase reduction in patient 1 was 300-100=200 U / L.

[0151] The lipase reduction levels of all patients were averaged to obtain the mean lipase reduction level.

[0152] Conclusion Summary:

[0153] 1. Symptom improvement: Through the analysis of symptom severity scores, it was found that the patients' symptoms were significantly improved after receiving the formula. The symptom scores of most patients were significantly reduced, and the average symptom improvement was relatively ideal. This shows that the formula has a more obvious effect in relieving the symptoms of liver and gallbladder damp-heat syndrome of acute pancreatitis, such as abdominal pain, abdominal distension, nausea, and vomiting, which may be effectively relieved, improving the quality of life of patients.

[0154] 2. Amylase and lipase levels: From the experimental data, it can be seen that the patients' amylase and lipase levels decreased significantly after treatment. This means that the formula may have a certain inhibitory effect on the inflammatory response of the pancreas and help reduce pancreatic damage. Amylase and lipase are important indicators for assessing the severity of pancreatitis. The reduction in their levels indicates that the inflammation of the pancreas has been controlled and the condition has improved.

[0155] 3. Comprehensive efficacy: Taking into account the improvement of symptoms and changes in laboratory indicators, this formula shows certain potential in the treatment of liver and gallbladder damp-heat syndrome of acute pancreatitis. It can not only relieve the patient's clinical symptoms, but also have a positive impact on the pathophysiological process of the pancreas and reduce inflammatory indicators.

[0156] 4. Mechanism exploration: Although this experiment preliminarily proves the efficacy of the formula, its specific mechanism of action needs further in-depth study. Possible mechanisms include the anti-inflammatory, choleretic, and bowel-clearing effects of the drugs in the formula, as well as their protective and repair effects on pancreatic cells. Future research can start from molecular biology and pharmacology to explore the mechanism of action of the formula and provide a more solid theoretical basis for its clinical application.

[0157] 5. Clinical application prospects: If this formula can be confirmed in further clinical studies, it will provide a new treatment option for patients with liver and gallbladder damp-heat syndrome of acute pancreatitis. Especially for those patients who do not respond well to traditional treatments or have side effects, this formula may have important clinical application value. However, before it can be widely used in clinical practice, rigorous clinical trials are needed to ensure its safety and effectiveness.

[0158] 6. Advantages of Chinese medicine: The results of this experiment also once again demonstrated the unique advantages of Chinese medicine in treating diseases. Chinese medicine emphasizes syndrome differentiation and treatment, and provides personalized treatment according to the individual differences and characteristics of the patient's condition. The application of this formula is a manifestation of the combination of Chinese medicine theory and practice, and provides a useful reference for Chinese medicine to play a greater role in the treatment of acute pancreatitis.

[0159] In summary, the experimental results provide a certain basis for further research and application of the formula for treating liver and gallbladder damp-heat syndrome of acute pancreatitis, but more research is still needed to improve and verify its efficacy and safety. The above embodiments are only used to illustrate the present invention and are not intended to limit the technical solutions described in the present invention. Although the present invention has been described in detail with reference to the above embodiments, the present invention is not limited to the above specific implementation methods. Therefore, any modification or replacement of the present invention; and all technical solutions and improvements thereof that do not depart from the spirit and scope of the invention are included in the scope of the claims of the present invention.

Claims

1. A formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis, characterized in that: The formula ingredients include: bupleurum, red peony root, immature bitter orange, Magnolia officinalis, raw rhubarb, Glauber's salt, Scutellaria baicalensis, Pinellia ternata, and Corydalis.

2. A formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis according to claim 1, characterized in that: Take the following ingredients: 15g of Bupleurum, 15g of Red Peony Root, 15g of Citrus Aurantium, 15g of Magnolia Officinalis, 10g of Raw Rhubarb, 10g of Glauber's Salt, 10g of Scutellaria Baicalensis, 10g of Pinellia Terrestris, and 15g of Corydalis.

3. A method for preparing a formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis, characterized in that: The following steps are involved: Step 1. Prepare the materials: according to the recipe, accurately weigh 15g of Bupleurum Root, 15g of Red Peony Root, 15g of Citrus Aurantium, 15g of Magnolia Officinalis, 10g of Raw Rhubarb, 10g of Sodium Sulfate, 10g of Scutellaria Baicalensis, 10g of Pinellia Tuber, and 15g of Corydalis, and prepare a casserole and a strainer; Step 2. Medicinal material processing: quickly rinse Bupleurum, Red Peony Root, Immature Citrus aurantium, Magnolia officinalis, Scutellaria baicalensis, Pinellia ternata, and Corydalis with clean water to remove impurities on the surface; Step 3. Soak the herbs: put the processed bupleurum, red peony root, immature bitter orange, Magnolia officinalis, scutellaria, pinellia tuber, and corydalis into a casserole, add appropriate amount of water, the water level should be 3-5 cm above the herbs, and soak the herbs for 20-30 minutes; Step 4. Decocting the herbs: After soaking, place the casserole on the stove and boil the water over high heat. After the water boils, immediately turn the heat to low and keep the medicinal liquid at a slightly boiling state for decocting. The decocting time is 30 minutes over low heat. Stir constantly during the decocting process to ensure that the herbs are heated evenly. Step 5. Add raw rhubarb: After 30 minutes, add the raw rhubarb to the casserole and continue to simmer for 5-10 minutes, keeping the heat low; Step 6. Filter out the liquid medicine: Use a fine filter to filter out the liquid medicine and pour it into a clean container; Step 7. Add the Glauber's salt: Add the Glauber's salt into the filtered medicinal solution and stir evenly to allow the Glauber's salt to fully dissolve.

4. The method for preparing a formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis according to claim 3, characterized in that: Step 2. During the treatment of medicinal materials, rinse the medicinal materials: put Bupleurum, Red Peony Root, Immature Citrus aurantium, Magnolia officinalis, Scutellaria baicalensis, Pinellia ternata, and Corydalis yanhusuo into different containers respectively, and slowly rinse the medicinal materials with clean water for 1-2 minutes. The rinsed water is filtered through a sieve with a sieve density of 200-300 mesh.

5. The method for preparing a formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis according to claim 4, characterized in that: Step 3. Soak the herbs: During the 30-minute soaking time, gently stir the herbs every 10 minutes. The temperature of the soaking water should be 20℃-26℃.

6. The method for preparing a formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis according to claim 5, characterized in that: Step 4. Boil the herbs: Turn on the stove and adjust the heat to high so that the water in the pot boils rapidly. When the water temperature reaches 100°C, the water starts to boil and record the time. After the water boils, immediately turn the heat to low to keep the medicinal liquid in a slightly boiling state. The temperature of the medicinal liquid should be maintained between 90-95℃. During the decoction process, use a stirring tool to gently stir the medicinal liquid every 5 minutes at a stirring speed of 30-40 revolutions per minute.

7. The method for preparing a formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis according to claim 6, characterized in that: Step 5. Add raw rhubarb: Keep simmering on low heat for 5-10 minutes. Start timing from the time the raw rhubarb is added. Use a timer to count the time. During the simmering process, use a stirring tool to gently stir the medicine every 2-3 minutes.

8. The method for preparing a formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis according to claim 7, characterized in that: Step 6. Filter out the medicine liquid: The whole process of filtering out the medicine liquid depends on the amount of medicine liquid. The filtration time is 8-15 minutes, and the temperature of the filtered medicine liquid is between 70-80℃. As the filtration process proceeds, the temperature gradually decreases. The filtration stirring speed is 15-20 revolutions per minute. Every 1-2 minutes, gently stir the medicine liquid with clean chopsticks or a stirring rod at a stirring speed of 15-20 revolutions per minute.

9. The method for preparing a formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis according to claim 8, characterized in that: Step 7. Adding Glauber's salt: slowly add Glauber's salt into the filtered medicinal solution, stirring while adding, the stirring speed is 30-40 revolutions per minute, so that the Glauber's salt can be fully dissolved. The process of adding Glauber's salt takes 5-10 minutes, the temperature of the medicinal solution is between 40-50℃, and the stirring speed of adding Glauber's salt is: 30-40 revolutions per minute.

10. An application of a formula for treating liver-gallbladder damp-heat syndrome of acute pancreatitis, characterized in that: The traditional Chinese medicine Tongjiang Qingpi decoction is used with a formula of 15g of Bupleurum chinense, 15g of Red Peony Root, 15g of Citrus aurantium, 15g of Magnolia officinalis, 10g of Raw Rhubarb, 10g of Glauber's Salt, 10g of Scutellaria baicalensis, 10g of Pinellia ternata, and 15g of Corydalis yanhusuo.

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