Transcranial light adjusting method and system based on energy transmission of laser light source through optical fiber bundle

Abstract

The invention provides a transcranial light adjusting method and system based on a laser light source and transmitting energy through an optical fiber bundle, relates to the technical field of physiotherapy, and mainly comprises a power supply, a controller, a laser, an optical fiber coupler, the optical fiber bundle, a lens group and the like. The optical fiber coupler couples laser output by the laser into the incident end of the optical fiber bundle; the emergent end of the optical fiber bundle is set as one or more sub optical fiber bundles, and the tail end of each sub optical fiber bundle is selectively butted with one lens group; when the emergent end of the optical fiber bundle is provided with a plurality of sub optical fiber bundles, the plurality of sub optical fiber bundles are respectively and correspondingly arranged at the back of the prefrontal lobe, the belly of the prefrontal lobe, the temporal lobe, the apical lobe and other physiotherapy positions which are effective for light; and when the tail ends of the plurality of sub-optical fiber bundles are not butted with the lens group, the emergent end of each sub-optical fiber bundle is set as an optical fiber array, and the optical fiber array is embedded into the light supply effective head position and is in contact with the scalp, so that the absorption rate and the reflectivity of the hair to near-infrared light are reduced.

Description

Technical Field

[0001] The present invention relates to physical therapy technology, and in particular to a transcranial light regulation method and system based on energy transmission of a laser light source through an optical fiber bundle. Background Art

[0002] Currently, all photobiomodulation therapy (PBMT) devices used for cognitive impairment use LED light sources. Since LED has a wide spectrum and is a spherical wave, its energy transmission rate through the cranial optical window is low, the energy density of the target surface is low, and the therapeutic efficiency is poor. For nasal passage therapy, due to the size limitations of LED, it is not convenient to arrange it in the nasal cavity, which makes it difficult to finely design and layout the optical system of the nasal passage. As a heat source, LED is prone to heat accumulation in the narrow nasal space, resulting in poor comfort of treatment. Summary of the invention

[0003] The embodiments of the present invention provide a transcranial light regulation method and system based on energy transmission of a laser light source through an optical fiber bundle, which can solve the problems in the prior art.

[0004] According to a first aspect of the embodiments of the present invention,

[0005] Provided is a transcranial light regulation method based on energy transmission of a laser light source through an optical fiber bundle, the method being applied to a physical therapy instrument, the physical therapy instrument mainly comprising a power supply, a controller, a laser, an optical fiber coupler, an optical fiber bundle and a lens group; the power supply is used to power electrical components of the physical therapy instrument; the controller is used to control the optical power, working time and flash frequency of the laser; the peak wavelength range of the laser output light is between 600-1080nm;

[0006] The fiber coupler couples the laser output by the laser into the incident end of the fiber bundle; the output end of the fiber bundle is set to one or more sub-fiber bundles, and the end of each sub-fiber bundle can be selectively connected to one of the lens groups; wherein, for the nasal physiotherapy channel, the output end of the fiber bundle corresponding to the light output end face of the sub-fiber bundle is designed to be an ellipse that fits the shape of the nasal cross-sectional interface, and the light output direction of the sub-fiber bundle points to the ventral prefrontal lobe and the hippocampus, so as to irradiate the ventral prefrontal lobe and the hippocampus respectively through the nasal passage;

[0007] For the transcranial therapy channel, the multiple sub-fiber bundles at the output end of the fiber bundle are respectively arranged at effective therapy positions such as the back of the frontal lobe, the temporal lobe and the parietal lobe, and are fixed by a head-mounted frame so that the light output axis of each sub-fiber bundle is perpendicular to the skull section plane at the corresponding irradiation point;

[0008] When the ends of the plurality of sub-fiber bundles are not connected to the lens group, the output end of each sub-fiber bundle is set as a fiber array, and the fiber array is embedded in the hair and contacts the scalp to reduce the absorption rate and reflectivity of the hair to near-infrared light.

[0009] In an optional embodiment,

[0010] When one of the sub-fiber bundles is used for nasal physiotherapy, the sub-fiber bundle can be split into two sub-fiber bundles for a second time, and the light-emitting end face of the sub-fiber bundle is designed to be an ellipse that fits the cross section of the nasal cavity. The light-emitting directions of the sub-fiber bundles are respectively directed to the belly of the prefrontal lobe and the hippocampus, and are used to irradiate the belly of the prefrontal lobe and the hippocampus through the nasal passage, respectively, including:

[0011] The optical fiber coupler couples the output of the laser light source to the light input end of the optical fiber bundle; the optical fiber bundle is made of quartz material, and the light end face of the sub-optical fiber bundle corresponding to the nasal physiotherapy channel at the light output end is an ellipse fitted according to the cross-sectional interface of the nasal cavity;

[0012] The ends of the sub-fiber bundles are each connected to a group of intranasal optical lens groups, which convert the approximately parallel light output by the modulated fiber bundle into a spherical beam with a small divergence angle, and guide the light output directions of the two sub-fiber bundles to the ventral prefrontal lobe and the hippocampus area respectively;

[0013] Through the coordinated work of the optical fiber bundle and the optical lens group in the nasal cavity, the near-infrared laser forms two focused light spots in the nasal cavity, which are accurately irradiated to the ventral prefrontal lobe and the hippocampus area respectively, thereby achieving precise photobiomodulation of specific brain areas.

[0014] In an optional embodiment,

[0015] The method further comprises:

[0016] The peak wavelength of the laser light source is within the range of 600-1080nm, and the output frequency is 10Hz or 40Hz; the optical fiber coupler couples the laser output of the light source to the light input end of the optical fiber bundle; the optical fiber bundle is made of quartz material, and its light output end is divided into N sub-optical fiber bundles;

[0017] The light input end and the light output end of the optical fiber bundle are processed by end face polishing, coating and tapering to improve the light energy coupling and transmission efficiency; the end of each sub-optical fiber bundle is connected to a lens group, which is composed of a series of spherical or aspherical lenses, and modulates the approximately parallel light output by the sub-optical fiber bundle into a light spot whose size and shape match the anatomical characteristics of the target brain area; the head-mounted frame is firmly fitted to the head by an adjustable elastic band or Velcro, and a fiber bundle fixing groove and a precision adjustment mechanism are reserved on the frame to fix the light output end of the optical fiber bundle and make the light output axis of each sub-optical fiber bundle perpendicular to the skull section plane of the corresponding brain area.

[0018] In an optional embodiment,

[0019] Modulating the nearly parallel light output from the sub-fiber bundle into a light spot whose size and shape match the anatomical features of the target brain area includes:

[0020] The three-dimensional structural data of the target brain area is acquired through magnetic resonance imaging or computer tomography, and the morphological parameters of the target brain area are extracted using image segmentation and reconstruction algorithms. The spatial range and depth requirements of light irradiation are determined in combination with the functional distribution and connectivity characteristics of the brain area, thereby determining the optimal range of the spot diameter and shape. The optical energy density distribution under different spot parameters is calculated in combination with the optical parameter model of brain tissue. The approximately parallel light output by the sub-fiber bundle is modulated into a spot whose size and shape match the anatomical characteristics of the target brain area.

[0021] In an optional embodiment,

[0022] When the ends of the plurality of sub-fiber bundles are not connected to the lens group, the output end of each sub-fiber bundle is set as a fiber array, and the fiber array is embedded in the hair and contacts the scalp to reduce the absorption rate and reflectivity of the hair to the near-infrared light, including:

[0023] The laser is connected to the light input end of the fiber bundle through a fiber coupler, and the light output end is divided into multiple sub-fiber bundles, each of which contains one or more single optical fibers; according to the anatomical structure of the head and the distribution of the illuminated area, the output end of the sub-fiber bundle is designed as a fiber array with a specific arrangement; the sub-fiber bundle array is installed at the corresponding position of the head-mounted frame; taking advantage of the small diameter of the optical fiber, the sub-fiber bundle array is embedded in the hair and in close contact with the scalp through fine embedding technology, and a micro-catheter or embedding needle is used to guide the optical fiber to contact the scalp and fix it with a biocompatible material; the optical performance of the sub-fiber bundle array is optimized, and optical fiber materials with high numerical aperture and low attenuation are selected. The optical fiber end face is polished and coated, and the fiber array arrangement and spacing are optimized through optical simulation and measurement.

[0024] In an optional embodiment,

[0025] Optimizing fiber array layout and spacing through optical simulation and measurement includes:

[0026] Establish an optical model of the optical fiber array and tissues such as the scalp and skull, input the geometric structure and optical parameter information of the optical fiber array and tissues such as the scalp and skull into the simulation software, and generate a three-dimensional optical model of the optical fiber array-tissues such as the scalp and skull by setting boundary conditions and meshing;

[0027] The migration process of photons in tissues such as the scalp and skull is simulated by the Monte Carlo method or the finite element method to obtain the light flux distribution, light intensity distribution and light transmission distribution of the optical fiber array in tissues such as the scalp and skull. By comparing the light distribution results under different arrangements and spacings, the optimized parameter range of the optical fiber array is preliminarily screened out.

[0028] Build a fiber array-scalp, skull and other tissue measurement platform, fix the fiber array on a precise three-dimensional mobile platform, select bionic materials with optical properties similar to those of scalp, skull and other tissues and place them under the platform, and place optical sensors inside or at the bottom of the bionic materials to measure the parameters of the optical flux, spectrum and light intensity distribution of the fiber array in the bionic materials;

[0029] By controlling the movement and rotation of the platform, the position and angle of the optical fiber array relative to the bionic material are changed, different arrangements and spacings are simulated, the optical parameters of the optical fiber array in the bionic material are measured, and compared with the simulation results. Through repeated experiments and statistical analysis, the optimization range and optimal value of the arrangement and spacing of the optical fiber array are obtained; based on the indicators of light uniformity, light penetration depth and light energy utilization efficiency, the optimal arrangement of the optical fiber array is determined.

[0030] According to a second aspect of the embodiments of the present invention,

[0031] Provided is a transcranial light regulation system based on energy transmission of a laser light source through an optical fiber bundle, which mainly includes: a power supply, a controller, a laser, an optical fiber coupler, an optical fiber bundle and a lens group; the power supply supplies power to the controller and the laser; the controller is used to control the output frequency of the laser to be 10Hz or 40Hz; the peak wavelength range of the laser is between 600-1080nm;

[0032] The first unit is used for the optical fiber coupler to couple the laser output by the laser into the incident end of the optical fiber bundle; the output end of the optical fiber bundle is set to one or more sub-optical fiber bundles, and the end of each sub-optical fiber bundle can be selectively connected to one of the lens groups; wherein, when one of the sub-optical fiber bundles is used for nasal physiotherapy, the sub-optical fiber bundle can be split into two sub-optical fiber bundles for a second time, and the light output end face of the sub-optical fiber bundle is designed to be an ellipse that fits the cross-section of the nasal cavity, and the light output directions of the two sub-optical fiber bundles are respectively directed to the ventral part of the prefrontal lobe and the hippocampus, so as to irradiate the ventral part of the prefrontal lobe and the hippocampus through the nasal passage respectively;

[0033] The second unit is used for, when the output end of the optical fiber bundle is set to a plurality of sub-optical fiber bundles, the plurality of sub-optical fiber bundles are respectively arranged at the effective brain therapy positions of the back of the frontal lobe, the temporal lobe and the parietal lobe, and fixed by a head-mounted frame, so that the light output axis of each sub-optical fiber bundle is perpendicular to the skull section plane at the corresponding irradiation point;

[0034] The third unit is used for setting the output end of each sub-fiber bundle as a fiber array when the ends of the plurality of sub-fiber bundles are not connected to the lens group, and embedding the fiber array into the hair at the effective brain treatment position and contacting the scalp to reduce the hair's absorption rate and reflectivity of near-infrared light.

[0035] According to a third aspect of the embodiments of the present invention,

[0036] An electronic device is provided, comprising:

[0037] processor;

[0038] a memory for storing processor-executable instructions;

[0039] The processor is configured to call the instructions stored in the memory to execute the aforementioned method.

[0040] A fourth aspect of the embodiments of the present invention is:

[0041] A computer-readable storage medium is provided, on which computer program instructions are stored. When the computer program instructions are executed by a processor, the aforementioned method is implemented.

[0042] The present application can achieve precise irradiation of different brain regions by setting the output end of the optical fiber bundle to one or more sub-optical fiber bundles, thereby improving the pertinence and effectiveness of physical therapy. For the transnasal physical therapy channel, when the output end of the optical fiber bundle corresponds to the sub-optical fiber bundle of the transnasal channel, an ellipse is fitted according to the cross-sectional shape of the nasal cavity, and the light output end irradiates the ventral part of the prefrontal lobe and the hippocampus respectively. The combination of the ellipse light output surface fitted according to the cross-sectional shape of the nasal cavity and the rear-end optical system can improve the penetration depth and energy utilization rate of light irradiation.

[0043] For the transcranial therapy channel, the output end of the optical fiber bundle is set to multiple sub-optical fiber bundles. By fixing the head-mounted frame and vertically setting the light output axis of the sub-optical fiber bundles, the position accuracy and angle consistency of the light irradiation can be ensured, and the repeatability and stability of the therapy can be improved. When the ends of the multiple sub-optical fiber bundles are not connected to the lens group, by embedding the optical fiber array into the hair and contacting the scalp, the absorption rate and reflectivity of the hair to near-infrared light can be reduced, the transmission efficiency of light energy and the scalp coupling can be improved, and the light loss and thermal effect can be reduced.

[0044] By adjusting the output frequency of the laser to 10Hz or 40Hz through the controller, the EEG rhythm can be regulated and brain function can be improved, thereby improving the biological effect and clinical efficacy of physical therapy. By selecting the peak wavelength of the laser in the range of 600-1080nm, the wavelength range of light can be matched according to the needs of physical therapy. For example, for the treatment of Alzheimer's disease, a laser with a peak wavelength of 810nm is selected to achieve the best transmittance of near-infrared light in brain tissue, improve the penetration depth and energy absorption rate of light in brain tissue, and enhance the photobiological effect and physical therapy. By coupling the laser output of the laser into the optical fiber bundle through the optical fiber coupler, low-loss transmission and uniform distribution of light energy can be achieved, the stability and consistency of light irradiation can be improved, and thermal effects and safety hazards can be reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] Figure 1 It is a flow chart of a transcranial light regulation method based on energy transmission of a laser light source through an optical fiber bundle according to an embodiment of the present invention;

[0046] Figure 2 It is a schematic diagram of the structure of a transcranial light modulation system based on energy transmission of a laser light source through an optical fiber bundle according to an embodiment of the present invention. DETAILED DESCRIPTION

[0047] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0048] The technical solution of the present invention is described in detail with specific embodiments below. The following specific embodiments can be combined with each other, and the same or similar concepts or processes may not be described in detail in some embodiments.

[0049] Figure 1 FIG. 1 is a flow chart of a transcranial light regulation method based on a laser light source transmitting energy through an optical fiber bundle according to an embodiment of the present invention. Figure 1 As shown, the method is applied to a physical therapy instrument, which mainly includes a power supply, a controller, a laser, a fiber coupler, a fiber bundle and a lens group; the power supply supplies power to electrical devices such as the controller and the laser; the controller is used to control the output frequency of the laser to be 10Hz or 40Hz; the peak wavelength range of the laser is between 600-1080nm;

[0050] S101. The fiber coupler couples the laser output by the laser into the incident end of the fiber bundle; the output end of the fiber bundle is set to one or more sub-fiber bundles, and the end of each sub-fiber bundle can be selectively connected to one of the lens groups; wherein, for the transnasal physiotherapy channel, when the output end of the fiber bundle corresponds to the sub-fiber bundle of the transnasal passage, an ellipse is fitted according to the cross-sectional shape of the nasal cavity, and the light output end irradiates the ventral part of the prefrontal lobe and the hippocampus respectively, the elliptical light output surface combined with the rear-end optical system fitted according to the cross-sectional shape of the nasal cavity can improve the penetration depth of light irradiation and energy utilization.

[0051] S102. For the transcranial therapy channel, multiple sub-fiber bundles corresponding to the transcranial channel are respectively arranged at effective therapy positions such as the back of the frontal lobe, the temporal lobe and the parietal lobe, and fixed by a head-mounted frame so that the light emitting axis of each sub-fiber bundle is perpendicular to the skull section plane at the corresponding irradiation point;

[0052] S103. When the ends of the plurality of sub-fiber bundles are not connected to the lens group, the output end of each sub-fiber bundle is set as a fiber array, and the fiber array is embedded in the hair and contacts the scalp to reduce the hair's absorption rate and reflectivity of near-infrared light.

[0053] In an optional embodiment,

[0054] When one of the sub-fiber bundles is used for nasal physiotherapy, the sub-fiber bundle can be split into two sub-fiber bundles for a second time, and the light-emitting end face of the sub-fiber bundle is designed to be an ellipse that fits the cross section of the nasal cavity. The light-emitting directions of the two sub-fiber bundles are respectively directed to the belly of the prefrontal lobe and the hippocampus, and are used to irradiate the belly of the prefrontal lobe and the hippocampus through the nasal passage, respectively, including:

[0055] The optical fiber coupler couples the output of the laser light source to the light input end of the optical fiber bundle; the optical fiber bundle is made of quartz material, and the light output end is designed as two sub-optical fiber bundles, and the light output end faces of the two sub-optical fiber bundles are elliptical;

[0056] The ends of the two sub-fiber bundles are respectively connected to a group of intranasal optical lens groups, which convert the approximately parallel light output by the modulated fiber bundle into a spherical beam with a small divergence angle, and guide the light output directions of the two sub-fiber bundles to the ventral prefrontal lobe and the hippocampus area respectively;

[0057] Through the coordinated work of the optical fiber bundle and the optical lens group in the nasal cavity, the near-infrared laser forms two focused light spots in the nasal cavity, which are accurately irradiated to the ventral prefrontal lobe and the hippocampus area respectively, thereby achieving precise photobiomodulation of specific brain areas.

[0058] Exemplarily, the light-emitting end of the optical fiber bundle is designed as two sub-bundles, and the ends of the two sub-bundles are respectively connected to a modulated optical lens group, and the light-emitting directions of the two sub-bundles are respectively directed to the ventral part of the prefrontal lobe and the hippocampus. The near-infrared laser passes through the optical fiber bundle and the lens group through the nasal passage to irradiate the ventral part of the prefrontal lobe and the hippocampus respectively. According to the structural characteristics of the nasal cavity and the nasal bone, the geometric end face of the light-emitting end of the optical fiber bundle is designed as an elliptical docking optical system. The laser irradiation frequency is adjustable to 10Hz or 40Hz.

[0059] Furthermore, this paper proposes a transnasal phototherapy system that uses the flexibility and splittable characteristics of the optical fiber bundle to efficiently transmit laser energy to the nasal cavity, and through a carefully designed optical system, guides the light energy to the ventral prefrontal lobe and hippocampus area, respectively, to achieve precise light irradiation of specific brain areas. The system is mainly composed of a laser light source, an optical fiber bundle, and an optical lens group.

[0060] The transnasal phototherapy system uses a laser operating in the near-infrared band as the light source, and its peak wavelength is selected in the range of 600-1080nm to ensure a high penetration depth and optical window energy transmission efficiency. The output power and frequency of the laser can be adjusted according to actual treatment needs, and the output frequency is usually set to 10Hz or 40Hz.

[0061] The fiber bundle adopts a unique 1 to 2 splitting structure design. The light input end of the bundle is connected to the laser light source through a fiber coupler, and the light output end is divided into two sub-fiber bundles (sub-bundles) for transmitting light energy to different brain regions in the nasal cavity. The fiber bundle is made of quartz fiber material to ensure good near-infrared light transmission characteristics and mechanical properties. The numerical aperture, core diameter, and cladding diameter of the fiber are optimized according to the characteristics of the incident laser and the anatomical structure of the nasal cavity to achieve efficient light energy coupling and transmission.

[0062] According to the internal structural characteristics of the nasal cavity and the spatial position relationship of the targeted brain area, this system optimizes the geometric shape of the optical fiber bundle light-emitting end. Through simulation analysis and experimental verification, it is determined that the optical fiber bundle light-emitting end face is designed to be elliptical and connected to the elliptical optical lens group to match the anatomical characteristics of the nasal cross section, improve the fit between the light spot and the nasal tissue, and reduce light energy loss.

[0063] At the end of each sub-beam, a group of carefully modulated optical lens groups are connected. By optimizing the curvature, thickness, material and other parameters of the lens group, the nearly parallel light output by the fiber optic bundle is modulated and converted into a spherical beam with a small divergence angle. The light output directions of the two sub-beams are guided to the ventral prefrontal lobe and hippocampus regions respectively. The lens group not only expands the spot size, but also effectively reduces the diffraction loss of light during transmission. Through the coordinated work of the fiber optic bundle and the lens group in the nasal cavity, the near-infrared laser forms two highly focused spots in the nasal cavity and accurately irradiates the ventral prefrontal lobe and hippocampus regions.

[0064] In an optional embodiment,

[0065] The method further comprises:

[0066] The peak wavelength of the laser light source is within the range of 600-1080nm, and the output frequency is 10Hz or 40Hz; the optical fiber coupler couples the output of the laser light source to the light input end of the optical fiber bundle; the optical fiber bundle is made of quartz material, and its light output end adopts a 1-to-N beam splitting structure design, which is divided into N sub-optical fiber bundles;

[0067] The light input end and the light output end of the optical fiber bundle are processed by end face polishing, coating and tapering to improve the light energy coupling and transmission efficiency; the end of each sub-optical fiber bundle is connected to a lens group, which is composed of a series of spherical or aspherical lenses, and modulates the approximately parallel light output by the sub-optical fiber bundle into a light spot whose size and shape match the anatomical characteristics of the target brain area; the head-mounted frame is firmly fitted to the head by an adjustable elastic band or Velcro, and a fiber bundle fixing groove and a precision adjustment mechanism are reserved on the frame to fix the light output end of the optical fiber bundle and make the light output axis of each sub-optical fiber bundle perpendicular to the skull section plane of the corresponding brain area.

[0068] For example, by utilizing the flexible, bendable and splittable characteristics of the optical fiber bundle, the light input end and the light output end of the optical fiber bundle can be designed as a 1-to-N mapping method, that is, a light input end and a laser are connected through a fiber coupler, and the light output end is divided into N sub-fiber bundles, and each sub-fiber bundle is connected to a lens group. A physical therapy plan can be designed according to physical therapy needs. For example, 6 illumination points are arranged at the physical therapy positions corresponding to the nasal passages of the dorsal frontal lobe, temporal lobe, and parietal lobe, and the light output end of the optical fiber bundle is fixed to the corresponding illumination area of ​​the head through a head-mounted frame, and the axis of the light beam is perpendicular to the skull section plane at the irradiation point. The laser irradiation frequency is adjustable to 10Hz or 40Hz.

[0069] Furthermore, this paper proposes a transcranial phototherapy system based on fiber beam splitting and energy transmission, which uses the flexible, bendable and splittable characteristics of the fiber beam to distribute the energy of a single laser light source to multiple brain regions of the head, thereby achieving multi-point and precise light irradiation of the brain. The transcranial phototherapy system uses a laser working in the near-infrared band as a light source, and its peak wavelength is selected in the range of 600-1080nm to ensure a high penetration depth and optical window energy transmission efficiency. The output power and frequency of the laser can be adjusted according to actual treatment needs, and the output frequency is usually set to 10Hz or 40Hz.

[0070] The fiber bundle adopts a 1 to N beam splitting structure design. The light input end of the bundle is connected to the laser light source through a fiber coupler, and the light output end is divided into N sub-fiber bundles (sub-bundles) to transmit light energy to different brain areas of the head. The number and arrangement of sub-bundles can be flexibly configured according to the needs of the physical therapy plan.

[0071] According to the functional location of the brain area and the treatment goal, select the appropriate light irradiation point position on the head. Taking the phototherapy program with the frontal lobe, temporal lobe and parietal lobe as the target brain area as an example, 6 light points can be arranged in the corresponding area. The specific location of the light point can be calibrated by referring to the brain function division map and the head anatomical landmarks.

[0072] A lens group is docked at the end of each sub-beam. By rationally designing the optical parameters of the lens group, the nearly parallel light output by the fiber bundle is modulated into a suitable light spot, and the size and shape of the light spot are matched with the anatomical features of the target brain area. The lens group can not only optimize the spatial distribution of light irradiation, but also reduce the energy loss of light during transmission.

[0073] In order to ensure the position stability and repeatability of the light irradiation point, a head-mounted frame is designed to fix the light-emitting end of the optical fiber bundle. The head-mounted frame is made of lightweight and breathable materials, and is firmly fitted to the head through adjustable elastic bands or Velcro. A fiber optic bundle fixing groove is reserved on the frame, and the light-emitting axis of each sub-beam is made perpendicular to the skull section plane at the irradiation point through a precision adjustment mechanism to improve the penetration efficiency and targeting of light energy. The output power, frequency, pulse width and other parameters of the laser are precisely adjusted through an integrated control system, and dynamic control is achieved according to the needs of the physical therapy plan. At the same time, a photoelectric sensor is integrated on the head-mounted frame to monitor key parameters such as the position, energy density and temperature of the light spot in real time to ensure the safety and effectiveness of the light irradiation process.

[0074] In an optional embodiment,

[0075] Modulating the nearly parallel light output from the sub-fiber bundle into a light spot whose size and shape match the anatomical features of the target brain area includes:

[0076] The three-dimensional structural data of the target brain area is acquired through magnetic resonance imaging or computer tomography, and the morphological parameters of the target brain area are extracted using image segmentation and reconstruction algorithms. The spatial range and depth requirements of light irradiation are determined in combination with the functional distribution and connectivity characteristics of the brain area, thereby determining the optimal range of the spot diameter and shape. The optical energy density distribution under different spot parameters is calculated in combination with the optical parameter model of brain tissue. The approximately parallel light output by the sub-fiber bundle is modulated into a spot whose size and shape match the anatomical characteristics of the target brain area.

[0077] For example, the 1-to-N splitting design of the fiber bundle utilizes the principle of light energy distribution in fiber optics. Through a special fiber arrangement and inter-beam coupling technology, the laser energy incident on the light input end of the fiber bundle is distributed to N sub-fiber bundles to achieve split transmission of light energy. The splitting ratio of the fiber bundle can be optimized by adjusting parameters such as the number of fibers in each sub-bundle, the arrangement method, and the distance between bundles.

[0078] In the cross section of the optical fiber bundle, N sub-bundles are usually arranged in a regular geometric pattern, such as a ring, rectangle or honeycomb, to ensure the uniformity and stability of light energy distribution. The arrangement of the sub-bundles is also adapted to the spatial distribution of the light irradiation points on the head, which facilitates the precise matching of the light spot with the brain area. The total diameter of the optical fiber bundle and the distance between the sub-bundles are optimized according to the characteristics of the optical fiber material, the wearable size design requirements and the manufacturing process to take into account both the light energy transmission efficiency and the mechanical flexibility.

[0079] In order to reduce the reflection loss of light energy at the end face of the optical fiber bundle and improve the coupling efficiency between the optical fiber and the light source and lens group, the light input and output ends of the optical fiber bundle need to be specially processed. Common methods include end face polishing, coating and tapered processing. Among them, end face polishing can make the optical fiber end face reach optical level flatness; coating treatment can prepare an anti-reflection film layer on the end face to reduce Fresnel reflection loss; tapered processing can achieve the transformation of the numerical aperture of the optical fiber and the regulation of the spot size by changing the geometric shape of the optical fiber end face.

[0080] The lens group is composed of a series of spherical or aspherical lenses. By reasonably selecting the material, curvature, spacing, aperture and other parameters of the lens, the light beam output by the optical fiber bundle is shaped and converged to form an ideal light irradiation spot. The lens group generally includes a collimating lens, a converging lens and a field lens, etc., which respectively realize the collimation, focusing and homogenization of the light beam. According to the light output characteristics and light spot requirements of the optical fiber bundle, the lens group can adopt different optical design schemes, such as a spherical lens combination, an aspherical lens combination or a diffractive optical element.

[0081] Use optical design software such as Zemax, CodeV or LightTools to model and simulate the lens group. Through ray tracing and wavefront calculation, evaluate the imaging quality, aberration characteristics and energy distribution of the lens group, and optimize the parameters. When optimizing the design, it is necessary to comprehensively consider factors such as the exit pupil characteristics, working wavelength, and incident angle of the fiber bundle, and take into account the processing difficulty and cost of the lens group. The optimized lens group can effectively suppress aberrations, improve the uniformity of the light spot, and reduce light energy loss.

[0082] By adjusting the focal length and magnification of the lens group, the size and shape of the light spot can be controlled to match the anatomical features of the target brain area. The selection of the light spot size must take into account the spatial selectivity and energy density requirements of light irradiation. Smaller light spots are conducive to precise brain stimulation, but may cause excessive local energy density and produce thermal effects; larger light spots are conducive to increasing the coverage and penetration depth of light irradiation, but may reduce spatial resolution. Therefore, it is necessary to select appropriate light spot parameters based on the functional characteristics of different brain areas and the photobiomodulation mechanism to achieve a balance between light irradiation effect and safety.

[0083] The lens group is precisely docked and fixed to the light-emitting end of the optical fiber bundle to form a stable optical system. In order to ensure the quality of the light spot and the accuracy of irradiation, the optical system needs to be calibrated in space and tested for optical performance. A high-precision optical platform and electric adjustment mechanism are used to achieve coaxial alignment and angle adjustment of the optical fiber bundle and the lens group. At the same time, optical detection instruments such as spectrometers, power meters, and light spot analyzers are used to measure and evaluate the spectrum, energy, and spatial distribution of the light spot, and feedback adjustments are made based on the results to ensure that the working performance of the optical system meets the requirements of light irradiation.

[0084] In an optional embodiment,

[0085] When the ends of the plurality of sub-fiber bundles are not connected to the lens group, the output end of each sub-fiber bundle is set as a fiber array, and the fiber array is embedded in the hair and contacts the scalp to reduce the absorption rate and reflectivity of the hair to the near-infrared light, including:

[0086] The laser is connected through a fiber coupler, and the light output end is divided into multiple sub-fiber bundles, each of which contains one or more single optical fibers; according to the anatomical structure of the head and the distribution of the illuminated area, the output end of the sub-fiber bundle is designed as a fiber array with a specific arrangement; the sub-fiber bundle array is installed at the corresponding position of the head-mounted frame; taking advantage of the small diameter of the optical fiber, the sub-fiber bundle array is embedded in the hair and in close contact with the scalp through fine embedding technology, and a micro-catheter or embedding needle is used to guide the optical fiber into the scalp and fix it with a biocompatible material; the optical performance of the sub-fiber bundle array is optimized, and optical fiber materials with high numerical aperture and low attenuation are selected. The optical fiber end face is polished and coated, and the fiber array arrangement and spacing are optimized through optical simulation and measurement.

[0087] Exemplarily, by utilizing the flexible, bendable, and splittable characteristics of the optical fiber bundle, the light input end and the light output end of the optical fiber bundle can be designed as a 1-to-N mapping method, that is, a light input end is connected to the laser through a fiber coupler, and the light output end is divided into N sub-fiber bundles. The output end of the sub-fiber bundle is a fiber array, and the characteristics of the small diameter of the optical fiber that can easily penetrate the hair and contact the scalp are utilized to reduce the hair's absorption rate and reflectivity of near-infrared light. For example, 6 illumination points are arranged at the physiotherapy positions corresponding to the nasal passages of the dorsal frontal lobe, temporal lobe, and parietal lobe. The light output end of each sub-bundle is fixed to the corresponding illumination area of ​​the head through a head-mounted frame. The sub-bundles are not connected to the lens group, but are dispersed into sub-fiber monomers or a group of several fiber monomers to be embedded in the hair and contact the scalp. The fiber array covers the corresponding illumination area of ​​the nasal passage. The laser irradiation frequency is adjustable to 10Hz or 40Hz.

[0088] In an optional embodiment,

[0089] Optimizing fiber array layout and spacing through optical simulation and measurement includes:

[0090] Establish an optical model of the optical fiber array and tissues such as the scalp and skull, input the geometric structure and optical parameter information of the optical fiber array and tissues such as the scalp and skull into the simulation software, and generate a three-dimensional optical model of the optical fiber array-tissues such as the scalp and skull by setting boundary conditions and meshing;

[0091] The migration process of photons in tissues such as the scalp and skull is simulated by the Monte Carlo method or the finite element method to obtain the light flux distribution, light intensity distribution and light transmission distribution of the optical fiber array in tissues such as the scalp and skull. By comparing the light distribution results under different arrangements and spacings, the optimized parameter range of the optical fiber array is preliminarily screened out.

[0092] Build a fiber array-scalp, skull and other tissue measurement platform, fix the fiber array on a precise three-dimensional mobile platform, select bionic materials with optical properties similar to those of scalp, skull and other tissues and place them under the platform, and place optical sensors inside or at the bottom of the bionic materials to measure the parameters of the optical flux, spectrum and light intensity distribution of the fiber array in the bionic materials;

[0093] By controlling the movement and rotation of the platform, the position and angle of the optical fiber array relative to the bionic material are changed, different arrangements and spacings are simulated, the optical parameters of the optical fiber array in the bionic material are measured, and compared with the simulation results. Through repeated experiments and statistical analysis, the optimization range and optimal value of the arrangement and spacing of the optical fiber array are obtained; based on the indicators of light uniformity, light penetration depth and light energy utilization efficiency, the optimal arrangement of the optical fiber array is determined.

[0094] For example, in order to optimize the arrangement and spacing of the optical fiber array, it is first necessary to establish an optical model of the optical fiber array and tissues such as the scalp and skull. Using the Monte Carlo method or the finite element method, the geometric structure, optical parameters and other information of the optical fiber array and tissues such as the scalp and skull are input into the simulation software, such as MCML, Zemax or COMSOL. Among them, the parameters of the optical fiber array include the optical fiber diameter, numerical aperture, refractive index, arrangement mode and spacing, etc.; the parameters of tissues such as the scalp and skull include the thickness, absorption coefficient, scattering coefficient and anisotropy factor of the epidermis, dermis, hair follicles, blood vessels, etc. By reasonably setting the boundary conditions and meshing, a three-dimensional optical model of the optical fiber array-scalp, skull and other tissues is generated.

[0095] The established optical model is used to simulate the light propagation of the fiber array in the scalp, skull and other tissues. The Monte Carlo method or the finite element method is used to simulate the migration process of photons in the scalp, skull and other tissues, including the emission, absorption, scattering and transmission of photons. By statistically analyzing the spatial distribution and energy distribution of photons, the light flux distribution, illuminance distribution and light transmission distribution of the fiber array in the scalp, skull and other tissues are obtained. Focus on the influence of the arrangement and spacing of the fiber array on the light distribution, such as the difference in light uniformity and light penetration depth under different arrangements such as linear arrangement, rectangular arrangement or circular arrangement. By comparing the light distribution results under different arrangements and spacings, the optimized fiber array parameter range is preliminarily screened out.

[0096] In order to verify the simulation results and further optimize the parameters of the fiber array, it is necessary to build a measurement platform for fiber array-scalp, skull and other tissues. A precise three-dimensional mobile platform is used to fix the fiber array on the platform, and the position and angle of the fiber array are precisely controlled by an electric or manual adjustment mechanism. Bionic materials with optical properties similar to those of tissues such as scalp and skull, such as silicone, agarose gel or animal scalp, skull, etc., are selected and placed under the platform to simulate the contact state between the fiber array and the scalp. Optical sensors such as optical power meters, spectrometers or CCD cameras are placed inside or at the bottom of the bionic material to measure parameters such as the light flux, spectrum and light intensity distribution of the fiber array in the bionic material.

[0097] Using the built measurement platform, we carried out the measurement experiment of fiber array-scalp, skull and other tissues. By controlling the movement and rotation of the platform, we changed the position and angle of the fiber array relative to the bionic material to simulate different arrangements and spacings. At each position and angle, we measured the parameters such as the light flux, spectrum and light intensity distribution of the fiber array in the bionic material, and compared and analyzed them with the simulation results. We focused on indicators such as light uniformity, light penetration depth and light energy utilization efficiency under different arrangements and spacings to evaluate the optical performance of the fiber array. Through repeated experiments and statistical analysis, we obtained the optimization range and optimal value of the arrangement and spacing of the fiber array.

[0098] The arrangement and spacing of the fiber array are optimized based on the results of comprehensive optical simulation and measurement experiments. According to indicators such as light uniformity, light penetration depth, and light energy utilization efficiency, the optimal arrangement of the fiber array is determined, such as linear arrangement, rectangular arrangement, or circular arrangement. Under the optimal arrangement, the balance point between light uniformity and light penetration depth is found by finely adjusting the fiber spacing, ensuring both the uniformity of the illumination area and sufficient light penetration depth. At the same time, considering the preparation process of the fiber array and the convenience of clinical application, the tolerance range of the fiber spacing is appropriately relaxed to improve the manufacturability and operability of the fiber array. Finally, the optimized fiber array arrangement and spacing parameters are obtained, which provide guidance for the subsequent preparation and clinical application of the fiber array.

[0099] In order to verify the performance of the optimized fiber array, actual samples need to be prepared and tested. According to the optimized arrangement and spacing parameters, the fiber array samples are prepared using precise fiber arrangement and fixation technology. The same conditions and methods as the simulation and measurement experiments are used to test the optical performance of the optimized fiber array in bionic materials or actual scalp, skull and other tissues, including light flux, spectrum, light intensity distribution and light penetration depth. The test results are compared with the performance of the fiber array before optimization to quantitatively evaluate the optimization effect. At the same time, through animal experiments or clinical trials, the therapeutic effect and safety of the optimized fiber array in actual transcranial phototherapy are evaluated to verify the contribution of optical optimization to improving the effect of phototherapy.

[0100] Based on the results of optical simulation, measurement experiments and verification tests, guidelines and specifications for the optimization design of fiber arrays are established. The general principles and specific methods for optimizing the arrangement and spacing of fiber arrays are summarized, including the establishment of optical models, the process of simulation analysis, the construction of measurement platforms, the design of experimental schemes, and the selection of optimization parameters. At the same time, according to the different tissue characteristics of scalp, skull and other tissues and phototherapy needs, reference ranges and recommended values ​​for the optimization design of fiber arrays are given, such as the selection basis and optimization strategy of fiber diameter, numerical aperture, arrangement mode and spacing. A standardized fiber array optimization design process and specification is formed to provide operational guidance for subsequent research and applications, and to improve the reliability and consistency of fiber array transcranial phototherapy.

[0101] Figure 2 FIG. 1 is a schematic diagram of the structure of a transcranial light modulation system based on a laser light source transmitting energy through an optical fiber bundle according to an embodiment of the present invention. Figure 2 As shown, the system includes a power supply, a controller, a laser, a fiber coupler, a fiber bundle and a lens group; the power supply supplies power to the controller and the laser; the controller is used to control the output frequency of the laser to be 10 Hz or 40 Hz; the peak wavelength range of the laser is 600-1080 nm;

[0102] The first unit is used for the optical fiber coupler to couple the laser output by the laser into the incident end of the optical fiber bundle; the output end of the optical fiber bundle is set to one or more sub-optical fiber bundles, and the end of each sub-optical fiber bundle can be selectively connected to one of the lens groups; wherein, when one of the sub-optical fiber bundles is used for nasal physiotherapy, the sub-optical fiber bundle can be split into two sub-optical fiber bundles for a second time, and the light output end face of the sub-optical fiber bundle is designed to be an ellipse that fits the cross-section of the nasal cavity, and the light output directions of the two sub-optical fiber bundles are respectively directed to the ventral part of the prefrontal lobe and the hippocampus, so as to irradiate the ventral part of the prefrontal lobe and the hippocampus through the nasal passage respectively;

[0103] The second unit is used for, when the output end of the optical fiber bundle is set to a plurality of sub-optical fiber bundles, the plurality of sub-optical fiber bundles are respectively arranged at the effective brain therapy positions of the back of the frontal lobe, the temporal lobe and the parietal lobe, and fixed by a head-mounted frame, so that the light output axis of each sub-optical fiber bundle is perpendicular to the skull section plane at the corresponding irradiation point;

[0104] The third unit is used for setting the output end of each sub-fiber bundle as a fiber array when the ends of the plurality of sub-fiber bundles are not connected to the lens group, and embedding the fiber array into the hair at the effective brain treatment position and contacting the scalp to reduce the hair's absorption rate and reflectivity of near-infrared light.

[0105] According to a third aspect of the embodiments of the present invention,

[0106] An electronic device is provided, comprising:

[0107] processor;

[0108] a memory for storing processor-executable instructions;

[0109] The processor is configured to call the instructions stored in the memory to execute the aforementioned method.

[0110] A fourth aspect of the embodiments of the present invention is:

[0111] A computer-readable storage medium is provided, on which computer program instructions are stored. When the computer program instructions are executed by a processor, the aforementioned method is implemented.

[0112] The present invention may be a method, an apparatus, a system and / or a computer program product. The computer program product may include a computer-readable storage medium carrying computer-readable program instructions for executing various aspects of the present invention.

[0113] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A transcranial photobiomodulation method based on energy transfer from a laser light source through an optical fiber bundle, characterized in that: The method is applied to a physical therapy device, which mainly includes a power supply, a controller, a laser, a fiber coupler, a fiber bundle and a lens group; the power supply supplies power to the controller and the laser; the controller is used to control the optical power, working time and flash frequency of the laser; the peak wavelength range of the laser is between 600-1080nm; The fiber coupler couples the laser output by the laser into the incident end of the fiber bundle; the output end of the fiber bundle is set to one or more sub-fiber bundles, and the end of each sub-fiber bundle can be selectively connected to one of the lens groups; wherein, when one of the sub-fiber bundles is used for nasal physiotherapy, the sub-fiber bundle can be split into two sub-fiber bundles for a second time, and the light output end face of the sub-fiber bundle is designed to be an ellipse that fits the cross section of the nasal cavity, and the light output directions of the two sub-fiber bundles are respectively directed to the ventral part of the prefrontal lobe and the hippocampus, so as to irradiate the ventral part of the prefrontal lobe and the hippocampus through the nasal passage respectively; When the output end of the optical fiber bundle is configured as a plurality of sub-optical fiber bundles, the plurality of sub-optical fiber bundles are respectively configured at the effective brain therapy positions of the back of the frontal lobe, the temporal lobe and the parietal lobe, and are fixed by a head-mounted frame so that the light output axis of each sub-optical fiber bundle is perpendicular to the skull section plane at the corresponding irradiation point; When the ends of the multiple sub-fiber bundles are not connected to the lens group, the output end of each sub-fiber bundle is set as a fiber array, and the fiber array is embedded in the hair at the effective brain treatment position and contacts the scalp to reduce the hair's absorption rate and reflectivity of near-infrared light.

2. The method according to claim 1, characterized in that When one of the sub-fiber bundles is used for nasal physiotherapy, the sub-fiber bundle can be split into two sub-fiber bundles for a second time, and the light-emitting end face of the sub-fiber bundle is designed to be an ellipse that fits the cross section of the nasal cavity. The light-emitting directions of the two sub-fiber bundles are respectively directed to the belly of the prefrontal lobe and the hippocampus, and are used to irradiate the belly of the prefrontal lobe and the hippocampus through the nasal passage, respectively, including: The optical fiber coupler couples the output of the laser light source to the light input end of the optical fiber bundle; the optical fiber bundle is made of quartz material. The ends of the two secondary-split sub-fiber bundles are respectively connected to a group of intranasal optical lens groups, which convert the approximately parallel light output by the modulated optical fiber bundle into a spherical beam with a small divergence angle, and guide the light output directions of the two sub-fiber bundles to the ventral prefrontal lobe and the hippocampus area respectively; Through the coordinated work of the optical fiber bundle and the optical lens group in the nasal cavity, the near-infrared laser forms two focused light spots in the nasal cavity, which are accurately irradiated to the ventral prefrontal lobe and the hippocampus area respectively, thereby achieving precise photobiomodulation of specific brain areas.

3. The method according to claim 1, characterized in that The method further comprises: The peak wavelength of the laser light source is within the range of 600-1080nm, and the output frequency is 10Hz or 40Hz; the optical fiber coupler couples the laser light source to the light input end of the optical fiber bundle; the optical fiber bundle is made of quartz material, and its light output end adopts a 1-to-N beam splitting structure design, which is divided into N sub-optical fiber bundles; The light input end and the light output end of the optical fiber bundle are processed by any one or more methods of end face polishing, coating and tapering to improve the light energy coupling and transmission efficiency; the end of each sub-optical fiber bundle is connected to a group of lens groups, which are composed of a series of spherical or aspherical lenses, and modulate the approximately parallel light output by the sub-optical fiber bundle into a light spot whose size and shape match the anatomical characteristics of the target brain area; the head-mounted frame is firmly fitted to the head by an adjustable elastic band or Velcro, and a fiber bundle fixing groove and a precision adjustment mechanism are reserved on the frame to fix the light output end of the optical fiber bundle and make the light output axis of each sub-optical fiber bundle perpendicular to the skull section plane of the corresponding brain area.

4. The method according to claim 3, characterized in that Modulating the nearly parallel light output from the sub-fiber bundle into a light spot whose size and shape match the anatomical features of the target brain area includes: The three-dimensional structural data of the target brain area is acquired through magnetic resonance imaging or computer tomography, and the morphological parameters of the target brain area are extracted using image segmentation and reconstruction algorithms. The spatial range and depth requirements of light irradiation are determined in combination with the functional distribution and connectivity characteristics of the brain area, thereby determining the optimal range of the spot diameter and shape. The optical energy density distribution under different spot parameters is calculated in combination with the optical parameter model of brain tissue. The approximately parallel light output by the sub-fiber bundle is modulated into a spot whose size and shape match the anatomical characteristics of the target brain area.

5. The method according to claim 1, characterized in that: When the ends of the plurality of sub-fiber bundles are not connected to the lens group, the output end of each sub-fiber bundle is configured as a fiber array, and the fiber array is embedded in the hair and contacts the scalp to reduce the absorption rate and reflectivity of the hair to the near-infrared light, including: The laser is connected through a fiber coupler, and the light output end is divided into multiple sub-fiber bundles, each of which contains one or more single optical fibers; according to the anatomical structure of the head and the distribution of the illuminated area, the output end of the sub-fiber bundle is designed as a fiber array with a specific arrangement; the sub-fiber bundle array is installed at the corresponding position of the head-mounted frame; taking advantage of the small diameter of the optical fiber, the sub-fiber bundle array is embedded in the hair and in close contact with the scalp through fine embedding technology, and a micro-catheter or embedding needle is used to guide the optical fiber into the scalp and fix it with a biocompatible material; the optical performance of the sub-fiber bundle array is optimized, and optical fiber materials with high numerical aperture and low attenuation are selected. The optical fiber end face is polished and coated, and the fiber array arrangement and spacing are optimized through optical simulation and measurement.

6. The method according to claim 5, characterized in that Optimizing fiber array layout and spacing through optical simulation and measurement includes: Establish an optical model of the optical fiber array and tissues such as the scalp and skull, input the geometric structure and optical parameter information of the optical fiber array and tissues such as the scalp and skull into the simulation software, and generate a three-dimensional optical model of the optical fiber array-tissues such as the scalp and skull by setting boundary conditions and meshing; The migration process of photons in tissues such as the scalp and skull is simulated by the Monte Carlo method or the finite element method to obtain the light flux distribution, light intensity distribution and light transmission distribution of the optical fiber array in tissues such as the scalp and skull. By comparing the light distribution results under different arrangements and spacings, the optimized parameter range of the optical fiber array is preliminarily screened out. Build a fiber array-scalp, skull and other tissue measurement platform, fix the fiber array on a precise three-dimensional mobile platform, select bionic materials with optical properties similar to those of scalp, skull and other tissues and place them under the platform, and place optical sensors inside or at the bottom of the bionic materials to measure the parameters of the optical flux, spectrum and light intensity distribution of the fiber array in the bionic materials; By controlling the movement and rotation of the platform, the position and angle of the optical fiber array relative to the bionic material are changed, different arrangements and spacings are simulated, the optical parameters of the optical fiber array in the bionic material are measured, and compared with the simulation results. Through repeated experiments and statistical analysis, the optimization range and optimal value of the arrangement and spacing of the optical fiber array are obtained; based on the indicators of light uniformity, light penetration depth and light energy utilization efficiency, the optimal arrangement of the optical fiber array is determined.

7. A transcranial light modulation system based on energy transmission of a laser light source through an optical fiber bundle, used to implement the method described in any one of claims 1 to 6, characterized in that: include: A power supply, a controller, a laser, a fiber coupler, a fiber bundle and a lens group; the power supply supplies power to the controller and the laser; the controller is used to control the output frequency of the laser to be 10Hz or 40Hz; the peak wavelength range of the laser is 600-1080nm; The first unit is used for the optical fiber coupler to couple the laser output by the laser into the incident end of the optical fiber bundle; the output end of the optical fiber bundle is set to one or more sub-optical fiber bundles, and the end of each sub-optical fiber bundle can be selectively connected to one of the lens groups; wherein, when one of the sub-optical fiber bundles is used for nasal physiotherapy, the sub-optical fiber bundle can be split into two sub-optical fiber bundles for a second time, and the light output end face of the sub-optical fiber bundle is designed to be an ellipse that fits the cross-section of the nasal cavity, and the light output directions of the two sub-optical fiber bundles are respectively directed to the ventral part of the prefrontal lobe and the hippocampus, so as to irradiate the ventral part of the prefrontal lobe and the hippocampus through the nasal passage respectively; The second unit, for transcranial channel therapy, the output end of the optical fiber bundle is set to a plurality of sub-optical fiber bundles, and the plurality of sub-optical fiber bundles are respectively arranged at the effective brain therapy positions of the back of the frontal lobe, the temporal lobe and the parietal lobe, and fixed by a head-mounted frame so that the light output axis of each sub-optical fiber bundle is perpendicular to the skull section plane at the corresponding irradiation point; The third unit is used for setting the output end of each sub-fiber bundle as a fiber array when the ends of the plurality of sub-fiber bundles are not connected to the lens group, and embedding the fiber array into the hair at the effective brain treatment position and contacting the scalp to reduce the hair's absorption rate and reflectivity of near-infrared light.

8. An electronic device, characterized in that: include: processor; a memory for storing processor-executable instructions; The processor is configured to call the instructions stored in the memory to execute the method according to any one of claims 1 to 6.

9. A computer-readable storage medium having computer program instructions stored thereon, characterized in that: When the computer program instructions are executed by a processor, the method according to any one of claims 1 to 6 is implemented.

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