Gas mixing equipment and method

Abstract

The invention discloses gas mixing equipment and method, and relates to the technical field of instrument detection analysis, the gas mixing equipment comprises an equipment shell, a diffusion assembly is arranged on the equipment shell, the gas diffusion assembly comprises a bottom sealing cover fixedly installed at the bottom of the equipment shell in a sealed mode, and the bottom of the bottom sealing cover is fixedly connected with the bottom sealing cover in a penetrating mode; a second air inlet pipe is fixedly connected to the bottom of the bottom sealing cover, a top sealing cover is fixedly installed at the top of the equipment shell in a sealed mode, an air outlet pipe penetrates through the top of the top sealing cover and is fixedly connected with the top of the top sealing cover, and a diffusion cavity and a preliminary mixing cavity are formed in the bottom end of the equipment shell; through the arrangement of the arc-shaped plate, when gas passes through the arc-shaped plate, turbulent flow is generated due to the change of the flowing direction and the speed, when the gas passes through the arc-shaped plate, due to the change of the flowing path, local pressure intensity changes can be caused, and the pressure intensity changes are beneficial to breaking the equilibrium state among gas molecules and further promoting gas mixing.

Description

Technical Field

[0001] The present invention relates to the technical field of instrument detection and analysis, and in particular to a gas mixture device and method. Background Art

[0002] In the prior art, when analyzing the molecular weight of macromolecular protein samples, it is necessary to use electrospray ionization technology to ionize the molecules of the sample to be detected. Specifically, the sample to be detected is driven into the ion source by the mobile phase, atomized by the atomizer needle and the electric field, and then dry nitrogen is introduced as a carrier gas at the other end of the device. After a certain reaction time, the sample to be detected is converted into gaseous molecular ions and introduced into the mass spectrometer heating capillary. Normally, the ionization efficiency of electrospray mass spectrometry is low, and only a few ten-thousandths of a substance can be ionized; In addition, in order to facilitate the ionization of molecules, the prior art usually needs to add some acidic substances as additives to the mobile phase to react with the sample to be detected to produce an effect. However, in this case, the content of the acidic additive is relatively small, resulting in a limited acid concentration in the mobile phase. After nitrogen is introduced as a carrier gas, it will be greatly diluted by nitrogen. In the dilution process, if the acidic position in the mobile phase is not fully mixed with nitrogen; Therefore, when the sample amount is low and the ionized substance to be detected is unevenly distributed in the mobile phase, the unevenly distributed sample amount will cause the mass spectrometry signal to be low or even no mass spectrometry signal, thus causing the mass spectrometry analysis of the sample to be detected to fail; To solve the above problems, we propose a gas mixing device and method. Summary of the invention

[0003] Technical issues solved In view of this, and in view of the deficiencies in the prior art, the present invention provides a gas mixing device and method to solve the problems raised in the above background technology.

[0004] Technical Solution To achieve the above-mentioned object, the present invention provides the following technical solutions: A gas mixture device, comprising a device housing, on which a diffusion component is arranged; The gas diffusion assembly includes a bottom sealing cover which is sealed and fixedly installed at the bottom of the equipment shell, a bottom sealing cover is fixedly connected through the bottom of the bottom sealing cover, an air inlet pipe 2 is fixedly connected to the bottom of the bottom sealing cover, a top sealing cover is sealed and fixedly installed on the top of the equipment shell, an air outlet pipe is fixedly connected through the top of the top sealing cover, a diffusion chamber is opened inside the bottom end of the equipment shell, a preliminary mixing chamber is opened inside the bottom end of the equipment shell, and an arc plate is fixedly connected to the bottom wall of the preliminary mixing chamber.

[0005] Preferably, the diffusion chamber is symmetrically opened at the bottom of the equipment shell, and the cross-section of the diffusion chamber consists of a rectangle and trapezoids symmetrically arranged at both ends of the rectangle. One end of the air intake pipe 1 and the air intake pipe 2 penetrates and extends to the inside of the bottom sealing cover, and the ends of the air intake pipe 1 and the air intake pipe 2 extending to the inside of the bottom sealing cover are respectively connected with the two diffusion chambers, the preliminary mixing chamber is arranged above the diffusion chamber, the preliminary mixing chamber is connected with the diffusion chamber, and the arc plate is arranged inside the preliminary mixing chamber.

[0006] Preferably, it also includes a dispersion component disposed inside the device housing; The dispersion component includes a dispersion chamber opened inside the device shell, a diffusion plate is arranged above the dispersion chamber, acceleration chambers are opened in a circular shape and equidistantly inside the diffusion plate, a column is arranged on the top of the diffusion plate, and a spiral chamber is opened through the center of the column.

[0007] Preferably, three dispersion chambers are provided, the dispersion chamber is arranged above the preliminary mixing chamber, and the dispersion chambers are connected to the preliminary mixing chamber, two diffusion plates are arranged in the vertical direction inside the equipment shell, and the outer walls of the diffusion plates are fixedly connected to the inner walls of the equipment shell, the acceleration chambers on the two diffusion plates are staggered, and a mixing chamber is formed between the dispersion chamber and the acceleration chamber.

[0008] Preferably, it also includes a stirring component disposed inside the device housing; The stirring component includes a stirring chamber opened inside the top of the equipment shell, a main shaft is fixedly connected to the cavity wall at the top of the stirring chamber, a rotating shaft is rotatably connected to the bottom end of the main shaft, a stirring blade 1 is fixedly connected to the outer wall of the middle part of the rotating shaft, a limiting spring is fixedly connected to the bottom end of the limiting spring away from the stirring blade 1, the limiting spring is sleeved on the outer wall of the rotating shaft, the stirring blade 2 is fixedly connected to the bottom end of the rotating shaft, and the spiral directions of the stirring blades 1 and 2 are opposite.

[0009] Preferably, it also includes an extrusion component arranged on the stirring blade; The extrusion assembly includes a connecting rod fixedly connected to the top of a stirring blade, the connecting rod is arranged around the axis of the rotating shaft, the top of the connecting rod is fixedly connected to a positioning block, the top of the positioning block is fixedly connected to a wedge block, the outer wall of the main shaft is fixedly connected to a limiting block, the inside of the limiting block is slidably connected to an extrusion rod, and the outer wall of the extrusion rod is sleeved with a return spring.

[0010] Preferably, the wedge block fits the outer wall of the main shaft, the extrusion rod is axially symmetrically arranged with reference to the central axis of the main shaft, the bottom end of the extrusion rod is located on the movement trajectory of the wedge block, and the return spring is arranged between the extrusion rod and the bottom of the limit block.

[0011] Preferably, it also includes a cleaning component arranged on the outer wall of the main shaft; The cleaning assembly includes an arc plate slidably connected to the outer wall of the main shaft, a support spring is symmetrically fixedly connected to the bottom of the arc plate, a connecting rod is rotatably connected to the top of the arc plate, and a friction block is rotatably connected to the end of the connecting rod away from the arc plate.

[0012] Preferably, the arc plate is symmetrically arranged on the outer wall of the main shaft, the bottom of the arc plate is in contact with the top of the two extrusion rods respectively, the connecting rod is arranged around the center of the main shaft, and the top of the friction block is in contact with the top inner wall of the equipment shell.

[0013] Preferably, a gas mixing method comprises the following steps: Step 1: A certain amount of acidic substance is injected into the pipeline through a syringe pump, and sprayed out through the atomizing nozzle set at the outlet of the pipeline. The liquid molecules of the acidic substance undergo Coulomb explosion when sprayed out of the atomizing nozzle to form ionized acidic gas. Then, the ionized acidic gas is injected into the gas to be detected again through another syringe pump, and after being fully mixed, an acidic atomized mixed gas is formed, wherein the mass ratio of the ionized acidic gas to the gas to be detected is 1:10-15, and the ionized acidic gas syringe pump controller controls the syringe pump pressure to be 0.3-0.5Mpa; Step 2: introducing the acidic atomized mixed gas obtained in step 1 into the interior of the device through the first air inlet pipe, and introducing the inert gas into the interior of the device through the second air inlet pipe; Wherein, a heating device is arranged outside the air inlet pipe 1 and the air inlet pipe 2, and the temperature set by the heating device is higher than the boiling point of the liquid molecules of the acidic substance, so as to maintain the gas phase state of the acidic substance inside the gas to be detected in the air inlet pipe 1; The inert gas is nitrogen. A heating device is synchronously arranged in the inlet pipe 2 for the inert gas to maintain the temperature balance between the acid atomized mixed gas and the inert gas in the inlet pipe 1 and the inlet pipe 2. A gas flow controller is connected to the inlet pipe 2 to control the amount of the inert gas. The gas flow controller controls the inert gas pressure to 3-5Mpa. Step 3: In the process of introducing the acidic atomized mixed gas and the inert gas into the device through the inlet pipe 1 and the inlet pipe 2 in step 2, the mass ratio of the molecules of the acidic atomized mixed gas and the inert gas needs to be controlled by the injection pump and the gas flow controller, and the ratio is 1:5; Step 4: After the acidic atomized mixed gas and the inert gas are introduced into the device through the inlet pipe 1 and the inlet pipe 2, the acidic atomized mixed gas and the inert gas are uniformly mixed in the stirring chamber, and then the mixed gas is introduced into the mass spectrometer through the outlet pipe and the mass spectrometer heating capillary, and the protein molecule content in the gas sample to be detected is analyzed by the mass spectrometer; Step 5: In step 4, the chromatographic conditions of the sample to be detected are: mobile phase A is the gas to be detected, mobile phase B is the ionized acidic gas; flow rate is 3.0 mL / min; the column temperature is 85°C; Mass spectrometry conditions: ESI ion source, positive ion mode, mass spectrometer heating capillary voltage 3.0 kV, sample cone voltage 200 V, ion source temperature 200 °C.

[0014] Beneficial Effects Compared with the prior art, the present invention provides a gas mixing device and method, which has the following beneficial effects: By setting the curved plate, when the gas passes through the curved plate, turbulence is generated due to the change in flow direction and speed. When the gas passes through the curved plate, the change in flow path will cause a change in local pressure. This pressure change helps to break the equilibrium state between gas molecules and further promote gas mixing. Through the setting of three dispersion chambers, when the gas flow rate of the middle dispersion chamber is larger, the gas flow rate is faster, which will produce stronger turbulence in the mixing chamber. Turbulence can increase the collision frequency between gas molecules, thereby promoting gas mixing. The higher gas flow rate in the middle position can reduce the dead zone in the mixing chamber, that is, those areas where the gas flows slowly or stagnates. The dead zone will lead to insufficient gas mixing, and the larger flow rate can effectively flush these areas; The spiral shape of the spiral cavity can continuously strengthen the gas swirl, thin the boundary layer, gradually increase the disturbance caused by the eddy current, and strengthen the radial mixing of the fluid in the tube. The design of the spiral pattern makes the flow path of the gas in the pipeline more complicated, increases the collision opportunities between gas molecules, and thus improves the uniformity of mixing. At the same time, the swirl effect generated by the spiral pattern is conducive to enhancing the heat and mass transfer between the fluids, facilitating the full mixing of the gas to be detected and the carrier gas, as well as the heat transfer between the two gases. The stirring blades 1 and 2 in opposite directions can form more eddies and turbulences inside the mixer, which help to break the laminar flow state between gas molecules and enhance the mixing effect between gases. The friction blocks arranged in a circular array are equally divided into two groups. During the movement of the friction blocks, they will rub against the top inner wall of the equipment shell, i.e., the top wall of the stirring chamber, to scrape off the condensed water attached to the top inner wall of the equipment shell during the gas mixing process, thereby preventing the condensed water from affecting the gas to be detected and the carrier gas after the mixing is completed, and at the same time preventing the accumulation of condensed water from affecting the use of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a schematic diagram of the overall appearance structure of the present invention; Figure 2 It is a schematic diagram of the cross-sectional structure of the bottom of the housing of the device of the present invention; Figure 3 It is a schematic diagram of the top cross-sectional structure of the housing of the device of the present invention; Figure 4It is a schematic diagram of the position relationship of the columnar body of the present invention; Figure 5 For the present invention Figure 4 A schematic diagram of the structure enlargement in the middle; Figure 6 It is a schematic diagram of the position relationship of the arc plate of the present invention; Figure 7 This is a schematic diagram of the position relationship of the friction block of the present invention; Figure 8 It is a schematic diagram of the internal planar structure of the housing of the device of the present invention; Fig. 9 For the present invention Figure 8 Enlarged schematic diagram of the structure at point B in the middle.

[0016] In the figure: 11, equipment housing; 12, bottom sealing cover; 13, air inlet pipe 1; 14, air inlet pipe 2; 15, top sealing cover; 16, air outlet pipe; 17, diffusion chamber; 18, preliminary mixing chamber; 19, curved plate; 21. dispersion chamber; 22. diffusion plate; 23. acceleration chamber; 24. columnar body; 25. spiral chamber; 31. stirring chamber; 32. main shaft; 33. rotating shaft; 34. stirring blade 1; 35. limit spring; 36. stirring blade 2; 41. connecting rod; 42. positioning block; 43. wedge block; 44. extrusion rod; 45. return spring; 46. limit block; 51. Arc plate; 52. Support spring; 53. Connecting rod; 54. Friction block. DETAILED DESCRIPTION

[0017] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0018] Embodiments of the present invention Embodiment 1 See also Figures 1 to 3 and Figure 6 , a gas mixture device, comprising a device housing 11, on which a diffusion component is arranged; The gas diffusion assembly includes a bottom sealing cover 12 which is sealed and fixedly installed at the bottom of the equipment shell 11, the bottom of the bottom sealing cover 12 is penetrated and fixedly connected with the bottom of the bottom sealing cover 12, the bottom of the bottom sealing cover 12 is fixedly connected with an air inlet pipe 14, the top of the equipment shell 11 is sealed and fixedly installed with a top sealing cover 15, the top of the top sealing cover 15 is penetrated and fixedly connected with an air outlet pipe 16, a diffusion chamber 17 is opened inside the bottom end of the equipment shell 11, a preliminary mixing chamber 18 is opened inside the bottom end of the equipment shell 11, and an arc plate 19 is fixedly connected to the bottom wall of the preliminary mixing chamber 18.

[0019] Among them, the diffusion chamber 17 is symmetrically opened at the bottom of the equipment shell 11, and the cross-section of the diffusion chamber 17 is composed of a rectangle and a trapezoid symmetrically arranged at both ends of the rectangle. One end of the intake pipe 13 and the intake pipe 2 14 penetrates and extends to the bottom sealing cover 12, and the ends of the intake pipe 13 and the intake pipe 2 14 extending to the bottom sealing cover 12 are respectively connected with the two diffusion chambers 17, and the preliminary mixing chamber 18 is arranged above the diffusion chamber 17, and the preliminary mixing chamber 18 is connected with the diffusion chamber 17, and the arc plate 19 is arranged inside the preliminary mixing chamber 18.

[0020] Among them, the air inlet pipe 13 is connected to the output port of the gas storage tank to be detected, and the air inlet pipe 2 14 is connected to the output port of the carrier gas storage tank used to mix the gas to be detected (the carrier gas is preferably dry nitrogen), and gas heating devices are provided on the air inlet pipe 1 13 and the air inlet pipe 2 14.

[0021] Further embodiments See also Figure 1 , Figure 4 , Figure 6 , the gas mixture device also includes a dispersion component arranged inside the device housing 11; The dispersion component includes a dispersion chamber 21 opened inside the device housing 11, a diffusion plate 22 is arranged above the dispersion chamber 21, and acceleration chambers 23 are opened in a circular shape and equidistantly inside the diffusion plate 22. A columnar body 24 is arranged on the top of the diffusion plate 22, and a spiral chamber 25 is opened through the center of the columnar body 24.

[0022] Among them, there are three dispersion chambers 21, which are arranged above the preliminary mixing chamber 18, and the dispersion chambers 21 are connected to the preliminary mixing chamber 18. Two diffusion plates 22 are arranged in the vertical direction inside the equipment shell 11, and the outer walls of the diffusion plates 22 are fixedly connected to the inner walls of the equipment shell 11. The acceleration chambers 23 on the two diffusion plates 22 are staggered, and a mixing chamber is formed between the dispersion chamber 21 and the acceleration chamber 23.

[0023] Among them, there are three dispersion chambers 21, and the three dispersion chambers 21 are arranged in parallel in the horizontal direction, and the cross-section of the dispersion chamber 21 is composed of a rectangle and a trapezoid symmetrically arranged at the upper and lower ends of the rectangle, and the inner diameter of the dispersion chamber 21 located in the center is larger than the dispersion chambers 21 located on both sides.

[0024] Further Embodiments See also Figures 3 to 5 and Figure 8 , the gas mixture device also includes a stirring component arranged inside the device housing 11; The stirring component includes a stirring chamber 31 opened inside the top of the equipment shell 11, a main shaft 32 is fixedly connected to the top cavity wall of the stirring chamber 31, a rotating shaft 33 is rotatably connected to the bottom end of the main shaft 32, a stirring blade 34 is fixedly connected to the outer wall of the middle part of the rotating shaft 33, a limiting spring 35 is fixedly connected to the bottom end of the stirring blade 34, a stirring blade 2 36 is fixedly connected to the end of the limiting spring 35 away from the stirring blade 1 34, the limiting spring 35 is sleeved on the outer wall of the rotating shaft 33, the stirring blade 2 36 is fixedly connected to the bottom end of the rotating shaft 33, and the spiral directions of the stirring blades 1 34 and 2 36 are opposite.

[0025] Further Embodiments See also Figures 3 to 5 , Figure 7 and Figure 8 The gas mixing device also includes an extrusion assembly disposed on the stirring blade 34; The extrusion assembly includes a connecting rod 41 fixedly connected to the top of the stirring blade 34, the connecting rod 41 is arranged around the axis of the rotating shaft 33, the top of the connecting rod 41 is fixedly connected to a positioning block 42, the top of the positioning block 42 is fixedly connected to a wedge block 43, the outer wall of the main shaft 32 is fixedly connected to a limit block 46, the inside of the limit block 46 is slidably connected to an extrusion rod 44, and the outer wall of the extrusion rod 44 is sleeved with a return spring 45.

[0026] Among them, the wedge block 43 fits the outer wall of the main shaft 32, the extrusion rod 44 is axially symmetrically arranged with the central axis of the main shaft 32 as a reference, the bottom end of the extrusion rod 44 is located on the movement trajectory of the wedge block 43, and the return spring 45 is arranged between the extrusion rod 44 and the bottom of the limit block 46.

[0027] Further Embodiments See also Figures 7 to 9 , the gas mixture device also includes a cleaning component arranged on the outer wall of the main shaft 32; The cleaning assembly includes an arc plate 51 slidably connected to the outer wall of the main shaft 32, a support spring 52 is symmetrically fixedly connected to the bottom of the arc plate 51, a connecting rod 53 is rotatably connected to the top of the arc plate 51, and a friction block 54 is rotatably connected to the end of the connecting rod 53 away from the arc plate 51.

[0028] The arc plate 51 is symmetrically arranged on the outer wall of the main shaft 32 , the bottom of the arc plate 51 contacts the top of the two extrusion rods 44 respectively, the connecting rod 53 is arranged around the center of the main shaft 32 , and the top of the friction block 54 is in contact with the top inner wall of the equipment housing 11 .

[0029] The friction block 54 is made of a magnetic material, the device housing 11 is made of a metal material that can be attracted by magnetism, and the friction block 54 is adsorbed inside the device housing 11 .

[0030] Embodiment 2 A gas mixing method comprises the following steps: Step 1: A certain amount of acidic substance is injected into the pipeline through a syringe pump, and sprayed out through the atomizing nozzle set at the outlet of the pipeline. The liquid molecules of the acidic substance undergo Coulomb explosion when sprayed out of the atomizing nozzle to form ionized acidic gas. Then, the ionized acidic gas is injected into the gas to be detected again through another syringe pump, and after being fully mixed, an acidic atomized mixed gas is formed, wherein the mass ratio of the ionized acidic gas to the gas to be detected is 1:10, and the ionized acidic gas syringe pump controller controls the syringe pump pressure to be 0.3Mpa; Step 2: The acidic atomized mixed gas obtained in step 1 is introduced into the interior of the device through the first air inlet pipe 13, and the inert gas is introduced into the interior of the device through the second air inlet pipe 14; Wherein, a heating device is disposed outside the air inlet pipe 13 and the air inlet pipe 2 14, and the temperature set by the heating device is higher than the boiling point of the acidic substance liquid molecule, so as to maintain the gas phase state of the acidic substance inside the gas to be detected in the air inlet pipe 1 13; Among them, the inert gas is nitrogen, and a heating device is synchronously arranged in the inlet pipe 14 for the inert gas to maintain the temperature balance of the acid atomized mixed gas and the inert gas in the inlet pipe 13 and the inlet pipe 2 14. A gas flow controller is connected to the inlet pipe 14 to control the gas dosage of the inert gas. The gas flow controller controls the inert gas pressure to 3Mpa; Step 3: In the process of introducing the acidic atomized mixed gas and the inert gas into the device through the inlet pipe 1 13 and the inlet pipe 2 14 in step 2, the mass ratio of the molecules of the acidic atomized mixed gas and the inert gas needs to be controlled by the injection pump and the gas flow controller, and the ratio is 1:5; Step 4: After the acidic atomized mixed gas and the inert gas are introduced into the device through the inlet pipe 1 13 and the inlet pipe 2 14, the acidic atomized mixed gas and the inert gas are uniformly mixed in the stirring chamber 31, and then the mixed gas is introduced into the mass spectrometer through the outlet pipe 16 and the mass spectrometer heating capillary, and the protein molecule content in the gas sample to be detected is analyzed by the mass spectrometer; Step 5: In Step 4, the chromatographic conditions for the sample to be detected are as follows: mobile phase A is the gas to be detected, and mobile phase B is the ionized acidic gas; the flow rate is 3.0 mL / min; the column temperature is 85 °C; The mass spectrometry conditions are as follows: ESI ion source, positive ion mode, the capillary voltage for mass spectrometry heating is 3.0 kV, the sample cone voltage is 200 V, and the ion source temperature is 200 °C.

[0031] The working process and principle of the overall content of the above embodiments are as follows: Introduction of the gas to be mixed: The staff connects the first inlet pipe 13 to the output port of the gas storage tank to be detected, and connects the second inlet pipe 14 to the output port of the carrier gas storage tank for mixing the gas to be detected (the carrier gas is preferably dry nitrogen). Gas heating devices are provided on both the first inlet pipe 13 and the second inlet pipe 14 to facilitate heating the gas to be detected and the carrier gas, accelerating the gas mixing process. Since the first inlet pipe 13 and the second inlet pipe 14 are respectively connected to two diffusion chambers 17 opened inside the equipment housing 11, and the cross-section of the diffusion chamber 17 consists of a rectangle and trapezoids symmetrically arranged at both ends of the rectangle, the gas to be detected and the carrier gas will respectively enter the inside of the equipment housing 11 through the two diffusion chambers 17; It should be noted that in the above process, the gas to be detected and the carrier gas enter the two diffusion chambers 17 in the same way, so only one of the gases will be described; When the gas to be detected enters the inside of the diffusion chamber 17 through the first inlet pipe 13, since the cross-section at the bottom of the diffusion chamber 17 is trapezoidal and the bottom dimension of the trapezoid is larger than the top dimension, and the two trapezoids of the cross-section of the diffusion chamber 17 are symmetrically arranged, when the gas to be detected enters the inside of the equipment housing 11, it will enter the inside of the diffusion chamber 17 through the bottom of the diffusion chamber 17, and the inner diameter of the diffusion chamber 17 into which the gas enters gradually decreases. The flow rate of the gas to be detected gradually increases during the above process, and when it enters the preliminary mixing chamber 18 connected to the diffusion chamber 17 from the inside of the diffusion chamber 17, the ejection speed of the gas to be detected gradually decreases; In the above process, in fluid dynamics, the continuity equation describes the principle of mass conservation of fluids (such as ideal gases when the flow rate is not very fast). For the flow in a pipe, the continuity equation can be expressed as: A1V1 = A2V2 Where A1 and A2 are the cross-sectional areas at two different cross-sections of the diffusion chamber 17, and V1 and V2 are the fluid velocities at the corresponding cross-sections. Since the inner diameter of the diffusion chamber 17 decreases, A2 < A1. To maintain mass conservation (i.e., the mass flowing in is equal to the mass flowing out), V2 must be greater than V1; Similarly, when the gas to be detected flows out from the diffusion chamber 17, the gas to be detected will change from an accelerated state to a slow or normal speed (the normal speed is the gas diffusion speed under standard atmospheric pressure, and the slow or accelerated state is the gas diffusion speed compared to the normal speed); Based on the above description, the carrier gas entering the interior of the device housing 11 from the other diffusion chamber 17 also enters the interior of the device housing 11 according to the same principle.

[0032] Mixture of the gas to be detected and the carrier gas: After the carrier gas and the gas to be detected flow out from the two diffusion chambers 17 respectively, they enter the preliminary mixing chamber 18 connected to the diffusion chamber 17 and contact the arc plate 19 disposed inside the preliminary mixing chamber 18; In the above process, the carrier gas and the gas to be detected begin to mix inside the preliminary mixing chamber 18, and first contact the curved surface at the bottom of the curved plate 19, and diffuse along the curved surface, increasing the chance of collision between gas molecules. When the gas passes through the curved plate 19, turbulence is generated due to the change in flow direction and speed. When the gas passes through the curved plate 19, the change in flow path will cause a change in local pressure. This pressure change helps to break the equilibrium state between gas molecules and further promote gas mixing.

[0033] After the gas to be detected and the carrier gas are mixed in the preliminary mixing chamber 18, they will enter the mixing chamber formed between the dispersion chamber 21 and the diffusion plate 22 through the dispersion chamber 21 connected to the preliminary mixing chamber 18; In the above process, since there are three dispersion chambers 21, and the three dispersion chambers 21 are arranged in parallel in the horizontal direction, and the cross-section of the dispersion chamber 21 is composed of a rectangle and a trapezoid symmetrically arranged at the upper and lower ends of the rectangle, and the inner diameter of the dispersion chamber 21 located in the center is larger than the dispersion chambers 21 located on both sides, when the gas after preliminary mixing enters the dispersion chamber 21, the gas will enter in three parts, among which the gas flow rate inside the dispersion chamber 21 located in the middle position will be larger than the gas flow rate inside the dispersion chambers 21 on both sides, and the flowing gas in the dispersion chamber 21 in the middle position will impact the diffusion plate 22 at a faster speed, and under the action of the diffusion plate 22, a reflux is formed inside the mixing chamber, and collides with the gas passing through the dispersion chambers 21 on both sides, so as to further mix the gas flowing out of the three dispersion chambers 21; When the gas flow rate of the dispersion chamber 21 in the middle is large, the gas flow rate is fast, which will generate stronger turbulence in the mixing chamber. Turbulence can increase the collision frequency between gas molecules, thereby promoting gas mixing. The higher gas flow rate in the middle position can reduce the dead zone in the mixing chamber, that is, those areas where the gas flows slowly or stagnates. The dead zone will cause insufficient gas mixing, and the larger flow rate can effectively flush these areas. The gas to be detected and the carrier gas further mixed in the mixing chamber will then pass through two diffusion plates 22, and enter the stirring chamber 31 through the acceleration chamber 23 opened on the diffusion plate 22 and the spiral chamber 25 opened in the columnar body 24 set above the diffusion plate 22; In the above process, since two diffuser plates 22 are provided, and the diffuser plates 22 are provided with acceleration chambers 23 in a ring array, the cross section of the acceleration chambers 23 is trapezoidal, and the two diffuser plates 22 are staggered in the vertical direction, when the mixed gas flows through the acceleration chambers 23, the acceleration chambers 23 can accelerate the mixed gas twice; After the mixed gas passes through the spiral cavity 25, the spiral shape of the spiral cavity 25 can continuously strengthen the gas swirl, thin the boundary layer, and gradually strengthen the disturbance caused by the eddy current, and strengthen the radial mixing of the fluid in the tube. The design of the spiral pattern makes the flow path of the gas in the pipeline more complicated, increases the collision opportunities between gas molecules, and thus improves the uniformity of mixing. At the same time, the swirl effect generated by the spiral pattern is conducive to enhancing the heat and mass transfer between the fluids, and facilitates the full mixing of the gas to be detected and the carrier gas and the heat transfer between the two gases. Further mixing of the gas to be detected and the carrier gas: Then, the mixed gas entering the stirring chamber 31 contacts the second stirring blade 36. The mixed gas flows in contact with the inclined surface of the second stirring blade 36, and generates a lateral driving force on the second stirring blade 36 through the inclined plane of the second stirring blade 36, so that the second stirring blade 36 is rotated. The second stirring blade 36 is slidably connected to the rotating shaft 33, so that the second stirring blade 36 passes through the rotating shaft 33, thereby driving the first stirring blade 34 fixedly connected to the rotating shaft 33 to rotate. In the above process, the stirring blade 1 34 is connected to the stirring blade 2 36 by the limit spring 35. Therefore, when the stirring blade 2 36 is blown by the airflow and rotates, the inclined blades of the stirring blade 2 36 are simultaneously blown by the vertical mixed airflow, generating an upward driving force, and compressing the limit spring 35 through the vertical movement of the stirring blade 2 36. After the limit spring 35 is compressed to a certain extent (in this state, the vertical force of the mixed airflow on the stirring blade 2 36 is less than the elastic force of the limit spring 35), the limit spring 35 is compressed to a certain extent. The elastic force of the spring 35 acts in the opposite direction on the stirring blade 36, causing the stirring blade 36 to move downward, and under the continuous blowing of the mixed airflow, the stirring blade 36 is caused to reciprocate in the vertical direction under the combined action of the airflow blowing and the limit spring 35, and then the periodic stretching and compression of the limit spring 35 causes the stirring blade 34 and the stirring blade 36 to vibrate periodically, thereby preventing the formation of cooling water on the outer surface of the stirring blade 34 and the stirring blade 36, which affects the use of the stirring blade 34 and the stirring blade 36; It should be noted that, since the gas to be detected and the carrier gas will be heated by the heating device when passing into the device, the mixing speed of the two gases will be accelerated, and in order to facilitate the detection of molecules in the prior art, some acidic substances must be added to the mobile phase as additives to react with the sample to be detected to produce an effect. Therefore, after the two gases enter the interior of the device, the gaseous gas to be detected and the carrier gas will contain certain water molecules. After the gaseous water molecules come into contact with the surface of the internal structure of the device, condensed water will gradually form and adhere to the surface of the structure as the temperature decreases, affecting the operation of the structure; The spiral directions of the stirring blade 1 34 and the stirring blade 2 36 are set to be opposite to each other. The stirring blade 1 34 and the stirring blade 2 36 in opposite directions can form more eddies and turbulences inside the mixer. These eddies and turbulences help to break the laminar flow state between gas molecules and enhance the mixing effect between gases. As the stirring blade 1 34 rotates under the action of the stirring blade 2 36, the positioning block 42 will rotate around the outer surface of the main shaft 32 under the action of the stirring blade 1 34 through the fixed connection between the connecting rod 41, the positioning block 42 and the stirring blade 1 34. At this time, the wedge block 43 fixedly connected to the upper surface of the positioning block 42 will rotate accordingly. Since the two symmetrically arranged extrusion rods 44 are located on the movement trajectory of the wedge block 43, the movement of the wedge block 43 will cause the extrusion rod 44 to move vertically inside the limit block 46, and the return spring 45 arranged between the extrusion rod 44 and the limit block 46 will be compressed during the movement. It should be noted that, in the above process, when one of the two extrusion rods 44 moves upward, the other extrusion rod 44 is in a state of being in contact with the top surface of the positioning block 42; Cleaning the top of the device: During the movement of the extrusion rods 44, since the top surfaces of the extrusion rods 44 are fitted with arc plates 51, and the arc plates 51 slide in contact with the outer surface of the main shaft 32, when one of the extrusion rods 44 moves upward, the arc plate 51 in contact with the top of the extrusion rod 44 moves vertically upward on the surface of the main shaft 32, and the friction block 54 connected to the other end of the connecting rod 53 is rotated to slide on the top wall of the stirring chamber 31 by rotating the connecting rod 53 connected to the arc plate 51. It should be noted that, in the initial state, the friction block 54 is set to be a magnetic material, the device housing 11 is set to be a magnetically attracted metal material, and the friction block 54 is adsorbed inside the device housing 11; In the above process, when the two arc plates 51 move up and down alternately, the support springs 52 fixedly connected at the corresponding bottom ends will be in a reciprocating stretching and contracting state, which is convenient for limiting the position of the arc plates 51 and assisting the arc plates 51 to return to the initial position; The friction blocks 54 arranged in a circular array are equally divided into two groups. During the movement of the friction blocks 54, they will rub against the top inner wall of the device housing 11, i.e., the top cavity wall of the stirring chamber 31, to scrape off the condensed water attached to the top inner wall of the device housing 11 during the gas mixing process, thereby preventing the condensed water from affecting the gas to be detected and the carrier gas after the mixing is completed, and at the same time preventing the accumulation of condensed water from affecting the use of the device; Finally, the uniformly mixed gas to be detected and carrier gas will flow into the detection mass spectrometer heating capillary through the gas outlet pipe 16 at the top of the device housing 11, and the gas mixing is completed.

[0034] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "including one..." do not exclude the presence of other identical elements in the process, method, article or device including the elements.

[0035] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A gas mixing device, comprising a device housing (11), characterized in that: A diffusion component is provided on the device housing (11); The gas diffusion assembly comprises a bottom sealing cover (12) which is sealed and fixedly mounted on the bottom of the device housing (11); the bottom of the bottom sealing cover (12) is penetrated and fixedly connected with the bottom sealing cover (12); the bottom of the bottom sealing cover (12) is fixedly connected with an air inlet pipe 2 (14); the top of the device housing (11) is sealed and fixedly mounted with a top sealing cover (15); the top of the top sealing cover (15) is penetrated and fixedly connected with an air outlet pipe (16); a diffusion chamber (17) is provided inside the bottom end of the device housing (11); a preliminary mixing chamber (18) is provided inside the bottom end of the device housing (11); and a curved plate (19) is fixedly connected to the bottom wall of the preliminary mixing chamber (18).

2. A gas mixture device according to claim 1, characterized in that: The diffusion chamber (17) is symmetrically opened at the bottom of the device housing (11); the cross section of the diffusion chamber (17) is composed of a rectangle and trapezoids symmetrically arranged at both ends of the rectangle; one end of the air intake pipe (13) and the air intake pipe (14) penetrate and extend into the bottom sealing cover (12); and one end of the air intake pipe (13) and the air intake pipe (14) extending into the bottom sealing cover (12) are respectively connected to the two diffusion chambers (17); the preliminary mixing chamber (18) is arranged above the diffusion chamber (17); the preliminary mixing chamber (18) is connected to the diffusion chamber (17); and the arc plate (19) is arranged inside the preliminary mixing chamber (18).

3. The gas mixture device according to claim 1, characterized in that: Also included is a dispersion component disposed inside the device housing (11); The dispersion component comprises a dispersion chamber (21) opened inside the device housing (11), a diffusion plate (22) is arranged above the dispersion chamber (21), acceleration chambers (23) are opened in a circular shape and at equal intervals inside the diffusion plate (22), a columnar body (24) is arranged on the top of the diffusion plate (22), and a spiral chamber (25) is opened through the center of the columnar body (24).

4. A gas mixture device according to claim 3, characterized in that: Three dispersion chambers (21) are provided, the dispersion chambers (21) are arranged above the preliminary mixing chamber (18), and the dispersion chambers (21) are communicated with the preliminary mixing chamber (18), two diffusion plates (22) are arranged in a vertical direction inside the device housing (11), and the outer walls of the diffusion plates (22) are fixedly connected to the inner walls of the device housing (11), the acceleration chambers (23) on the two diffusion plates (22) are arranged in an alternating manner, and a mixing chamber is formed between the dispersion chamber (21) and the acceleration chamber (23).

5. The gas mixture device according to claim 1, characterized in that: Also included is a stirring component disposed inside the device housing (11); The stirring assembly comprises a stirring chamber (31) opened inside the top end of the device housing (11); a main shaft (32) is fixedly connected to the top wall of the stirring chamber (31); a rotating shaft (33) is rotatably connected to the bottom end of the main shaft (32); a stirring blade (34) is fixedly connected to the outer wall of the middle part of the rotating shaft (33); a limiting spring (35) is fixedly connected to the bottom end of the stirring blade (34); a stirring blade (36) is fixedly connected to the end of the limiting spring (35) away from the stirring blade (34); the limiting spring (35) is sleeved on the outer wall of the rotating shaft (33); the stirring blade (36) is fixedly connected to the bottom end of the rotating shaft (33); and the spiral directions of the stirring blades (34) and (36) are opposite.

6. A gas mixture device according to claim 5, characterized in that: Also included is an extrusion assembly disposed on the stirring blade (34); The extrusion assembly comprises a connecting rod (41) fixedly connected to the top of the stirring blade (34), the connecting rod (41) being arranged around the axis of the rotating shaft (33), the top of the connecting rod (41) being fixedly connected to a positioning block (42), the top of the positioning block (42) being fixedly connected to a wedge block (43), the outer wall of the main shaft (32) being fixedly connected to a limiting block (46), the inside of the limiting block (46) being slidably connected to an extrusion rod (44), and the outer wall of the extrusion rod (44) being sleeved with a return spring (45).

7. A gas mixture device according to claim 6, characterized in that: The wedge block (43) fits the outer wall of the main shaft (32), the extrusion rod (44) is axially symmetrically arranged with the central axis of the main shaft (32) as a reference, the bottom end of the extrusion rod (44) is located on the movement track of the wedge block (43), and the return spring (45) is arranged between the extrusion rod (44) and the bottom of the limit block (46).

8. The gas mixture device according to claim 6, characterized in that: Also included is a cleaning assembly disposed on the outer wall of the main shaft (32); The cleaning assembly comprises an arc plate (51) slidably connected to the outer wall of the main shaft (32); a support spring (52) is symmetrically fixedly connected to the bottom of the arc plate (51); a connecting rod (53) is rotatably connected to the top of the arc plate (51); and a friction block (54) is rotatably connected to one end of the connecting rod (53) away from the arc plate (51).

9. A gas mixture device according to claim 8, characterized in that: The arc plate (51) is symmetrically arranged on the outer wall of the main shaft (32), the bottom of the arc plate (51) is in contact with the top ends of the two extrusion rods (44) respectively, the connecting rod (53) is arranged around the center of the main shaft (32), and the top of the friction block (54) is in contact with the top inner wall of the device housing (11).

10. A gas mixing method, applied to a gas mixing device according to any one of claims 1 to 9, characterized in that: The following steps are involved: Step 1: A certain amount of acidic substance is injected into the pipeline through a syringe pump, and sprayed out through the atomizing nozzle set at the outlet of the pipeline. The liquid molecules of the acidic substance undergo Coulomb explosion when sprayed out of the atomizing nozzle to form ionized acidic gas. Then, the ionized acidic gas is injected into the gas to be detected again through another syringe pump, and after being fully mixed, an acidic atomized mixed gas is formed, wherein the mass ratio of the ionized acidic gas to the gas to be detected is 1:10-15, and the ionized acidic gas syringe pump controller controls the syringe pump pressure to be 0.3-0.5Mpa; Step 2: The acidic atomized mixed gas obtained in step 1 is introduced into the interior of the device through the first air inlet pipe (13), and the inert gas is introduced into the interior of the device through the second air inlet pipe (14); Wherein, a heating device is provided outside the air inlet pipe 1 (13) and the air inlet pipe 2 (14), and the temperature set by the heating device is higher than the boiling point of the acidic substance liquid molecules, so as to maintain the gas phase state of the acidic substance inside the gas to be detected in the air inlet pipe 1 (13); The inert gas is nitrogen. A heating device is synchronously arranged in the second air inlet pipe (14) through which the inert gas is introduced, for maintaining the temperature balance between the acid atomized mixed gas and the inert gas in the first air inlet pipe (13) and the second air inlet pipe (14). The second air inlet pipe (14) is connected with a gas flow controller for controlling the amount of the inert gas. The gas flow controller controls the pressure of the inert gas to be 3-5Mpa. Step 3: In the process of introducing the acidic atomized mixed gas and the inert gas into the device through the inlet pipe 1 (13) and the inlet pipe 2 (14) in step 2, the mass ratio of the molecules of the acidic atomized mixed gas and the inert gas needs to be controlled by the injection pump and the gas flow controller, and the ratio is 1:5; Step 4: After the acidic atomized mixed gas and the inert gas are introduced into the device through the inlet pipe 1 (13) and the inlet pipe 2 (14), the acidic atomized mixed gas and the inert gas are uniformly mixed in the stirring chamber (31), and then the mixed gas is introduced into the mass spectrometer through the outlet pipe (16) and the mass spectrometer heating capillary, and the protein molecule content in the gas sample to be detected is analyzed by the mass spectrometer; Step 5: In step 4, the chromatographic conditions of the sample to be detected are: mobile phase A is the gas to be detected, mobile phase B is the ionized acidic gas; flow rate is 3.0 mL / min; the column temperature is 85°C; Mass spectrometry conditions: ESI ion source, positive ion mode, mass spectrometer heating capillary voltage 3.0 kV, sample cone voltage 200 V, ion source temperature 200 °C.

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