Outer space biological loading device

By designing an outer space bioloading device that adopts microfluidic chip technology and multi-channel design, the problem that existing devices are difficult to adapt to customized tasks in the space environment is solved, and efficient automated full-process operation and real-time monitoring are achieved to ensure the smooth progress and reliability of the experiment.

CN119530007APending Publication Date: 2025-02-28上海邦先医疗科技有限公司
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Patent Information

Application Number
CN202411743715.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-30
Publication Date
2025-02-28

AI Technical Summary

Technical Problem

The existing bioloading devices are difficult to adapt to customized tasks such as bacterial culture, cell culture and protein crystallization in space environments. They lack special designs for the space environment and cannot effectively simulate space environment conditions such as microgravity, cosmic rays, heavy particles and weak magnetic fields. The automation process operation is not accurate and efficient enough, and the remote control and real-time monitoring functions are not perfect.

Method used

An outer space bioloading device is designed, adopting microfluidic chip technology and multi-channel design, combined with temperature control modules, automated operating systems and remote control mechanisms, which can simulate and adapt to microgravity, cosmic rays and other conditions in the space environment, and realize efficient automated full-process operation and real-time monitoring.

Benefits of technology

The device can effectively adapt to customized tasks such as bacterial culture, cell culture and protein crystallization in space, ensure the smooth progress of the experiment, and through remote control and real-time monitoring functions, it can timely adjust and intervene in the experimental process to improve the reliability and efficiency of the experiment.

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Abstract

The invention discloses an outer space biological loading device, which relates to the technical field of biological loading, and comprises a bottom plate, a chip mounting base, a piston push plate assembly and an optical module array assembly which are mounted on a three-motor driving module to form a middleware, the whole middleware is placed on the upper surfaces of the left supporting frame and the right supporting frame, the base, the left supporting frame and the right supporting frame are locked through four inner hexagonal two-combination screws, in the pressing block assembly, two guide shafts are installed in corresponding holes of a first pressing block in a pressed mode, and a trapezoidal lead screw and a trapezoidal nut are assembled into a set to be placed on the upper surface of the first pressing block. A through hole in the trapezoidal nut is aligned with a threaded hole in the pressing block I and is fastened through four inner hexagonal two-combination screws V. According to the device, a micro-fluidic chip technology is applied, a multi-channel design is adopted, and customized detection services including cell culture, bacterial culture, organoid culture, protein crystallization and the like can be realized according to user requirements.
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Description

Technical Field

[0001] The present invention relates to the field of biological payload technology, and in particular to an outer space biological payload device. Background Art

[0002] The function of the biological payload device is to serve biological samples and organisms. Biological samples or organisms are all active. The role of the biological payload device is to ensure that biological samples or organisms can still survive normally in the microgravity environment of space and provide them with the environment they need, such as suitable temperature, pressure and corresponding nutrient supply and waste disposal. The space biological payload device mainly provides automated full-process operations for the cultivation of cells and microorganisms and protein crystallization after the satellite is launched. It uses the space biological payload device and utilizes space environments such as microgravity, cosmic rays, heavy particles and weak magnetic fields to study the growth of cells and bacteria and their effects on protein crystallization.

[0003] However, during the implementation of the above technical solution, it was found that there were at least the following technical problems:

[0004] Existing devices may have the following problems that make them unsuitable for customized tasks such as bacterial culture, cell culture, and protein crystallization in space: they may lack special designs for the space environment and be unable to effectively simulate space environmental conditions such as microgravity, cosmic rays, heavy particles, and weak magnetic fields; they may not be able to meet the strict requirements of these tasks in terms of temperature, pressure, nutrient supply, and waste disposal; automated full-process operations may not be precise and efficient enough to ensure the smooth progress of the experiment; remote control and real-time monitoring functions may be imperfect, making it impossible to adjust and intervene in the experimental process in a timely manner. Summary of the invention

[0005] 1. Technical issues to be solved

[0006] In view of the shortcomings of the prior art, the present invention provides an outer space biological payload device, which solves the following problems that the existing devices may have and cannot adapt to customized tasks such as bacterial culture, cell culture, protein crystallization, etc. in space: they may lack special design for the space environment and cannot effectively simulate space environmental conditions such as microgravity, cosmic rays, heavy particles and weak magnetic fields; they may not be able to meet the strict requirements of these tasks in terms of temperature, pressure, nutrient supply and waste disposal; the automated full-process operation may not be accurate and efficient enough to ensure the smooth progress of the experiment; the remote control and real-time monitoring functions may be imperfect, and it is difficult to adjust and intervene in the experimental process in time.

[0007] (II) Technical solution

[0008] To achieve the above objectives, the present invention is implemented through the following technical solutions:

[0009] An outer space biological payload device comprises a bottom plate, a chip mounting base, and the outer space biological payload device is also provided with a remote control mechanism, a side pressure plate, a three-combination screw of an inner hexagon socket, a microfluidic chip, a polyurethane cushion, a temperature control module, a left support frame, a two-combination screw of an inner hexagon socket, a two-combination screw of an inner hexagon socket, a chip upper pressure plate, a three-combination screw of an inner hexagon socket, a right support frame, a four-combination screw of an inner hexagon socket, a two-combination screw of an inner hexagon socket, a two-combination screw of an inner hexagon socket, a screw nut motion assembly, a piston push plate assembly, an optical module array assembly, a three-motor drive module, a pressure block, a trapezoidal screw, a trapezoidal copper nut, a guide shaft, a five-combination screw of an inner hexagon socket, a pressure block, a guide shaft, a screw nut, a three-combination screw of an inner hexagon socket Thread 3, optical bracket, optical module, self-lubricating sleeve 1, two hexagon socket screws 6, adapter, two hexagon socket screws 7, light baffle, base, self-lubricating sleeve 2, stepper motor, coupling 1, two hexagon socket screws 8, encoder bracket 1, countersunk screw, two hexagon socket screws 9, encoder, encoder bracket 2, coupling 2, two hexagon socket screws 10, stepper motor, coupling 3, two hexagon socket screws 11, end cover, deep groove ball bearing, encoder bracket 3, three hexagon socket screws 4, photoelectric sensor, two hexagon socket screws 12, guide shaft 3, chip piston, chip vent cover, thermal block, temperature sensor, heating film 1, thermal insulation foam 1 , insulation foam 2, heating film 2, side pressure plate, microfluidic chip, connected to the chip mounting base through the chip upper pressure plate and polyurethane cushion, the side pressure plate supports the side of the microfluidic chip, temperature control module, arranged on the chip mounting base, left support frame and right support frame, respectively arranged on both sides of the bottom plate, pressure block assembly, including pressure block 1, trapezoidal screw, trapezoidal copper nut, guide shaft 1 and two hexagon socket combination screws 5, piston push plate assembly, including pressure block 2, guide shaft 2, screw nut and three hexagon socket combination screws 3, optical module array assembly, including optical bracket, optical module, self-lubricating sleeve 1, two hexagon socket combination screws 6, adapter, two hexagon socket combination screws 7 and light baffle, three motor drive modules, It includes a base, a self-lubricating sleeve 2, a stepper motor, a coupling 1, two hexagon socket screws 8, an encoder bracket 1, a countersunk screw, two hexagon socket screws 9, an encoder, an encoder bracket 2, a coupling 2, two hexagon socket screws 10, a stepper motor, a coupling 3, two hexagon socket screws 11, an end cover, a deep groove ball bearing, an encoder bracket 3, three hexagon socket screws 4, a photoelectric sensor and two hexagon socket screws 12. The pressure block assembly, the piston push plate assembly and the optical module array assembly are installed on the three-motor drive module to form a middle piece. The middle piece is placed on the upper surface of the left support frame and the right support frame as a whole, and the base is locked to the left support frame and the right support frame by two hexagon socket screws 4.

[0010] Preferably: the temperature control module includes a heat conducting block, a temperature sensor, a heating film 1, a thermal insulation foam 1, a thermal insulation foam 2 and a heating film 2.

[0011] Preferably: in the pressing block assembly, two guide shafts are pressed into corresponding holes of the pressing block, a set of trapezoidal screw rods and trapezoidal nuts are assembled and placed on the upper surface of the pressing block, the through hole on the trapezoidal nut is aligned with the threaded hole on the pressing block, and fastened by four hexagon socket combination screws.

[0012] Preferably, the two guide shafts are pressed into the corresponding holes of the pressing block, the screw nuts are inserted into the corresponding holes of the pressing block and the screw holes of the two are aligned, and the two are fixed by three hexagon socket combination screws.

[0013] Preferably: the three optical modules are mounted on the optical bracket by two hexagon socket combination screws, a self-lubricating sleeve is pressed into the corresponding hole of the adapter, the light baffle is fixed to the adapter by two hexagon socket combination screws, the screw nut is installed in the corresponding hole of the adapter and the two screw holes are aligned, and the two are assembled together by three hexagon socket combination screws.

[0014] Preferably: guide shaft three, all self-lubricating sleeves two and two deep groove ball bearings are pressed into the corresponding holes of the base, the end cover is installed on one side of the deep groove ball bearing, the bearing is pressed by four hexagon socket two combination screws eleven, coupling one is connected to the stepper motor to form an intermediate piece, coupling two and coupling three are assembled on the two shaft ends of the stepper motor to form an intermediate piece, the intermediate pieces are respectively installed at, fastened by hexagon socket two combination screws twelve, the intermediate piece is installed at the corresponding position of the base, fastened by four hexagon socket two combination screws ten, encoder bracket one is installed at the corresponding position of the base by countersunk screws, encoder bracket two and encoder bracket three are installed at the corresponding position of the base by hexagon socket two combination screws nine, the encoder is respectively installed at the corresponding positions of encoder bracket one, encoder bracket two and encoder bracket three, the encoder is connected to each bracket by hexagon socket two combination screws eight, the encoder shaft is respectively inserted into the coupling one and coupling two holes, the screws on the coupling are tightened, the encoder shaft is clamped, and the photoelectric sensor is installed on the base by hexagon socket three combination screws four.

[0015] Preferably: the chip mounting base is connected to the temperature control module by two hexagon socket combination screws, the microfluidic chip is placed in the corresponding groove of the heat conductive block, the other end of the bottom of the chip is tightly attached to the chip mounting base, a polyurethane cushion and a chip upper pressure plate are placed on the upper surface of the microfluidic chip in sequence, the through holes of the chip upper pressure plate are aligned with the corresponding screw holes of the chip mounting base and the bottom plate, and are fastened by two hexagon socket combination screws, and the side pressure plate is fastened by one hexagon socket combination screw.

[0016] Preferably, the left support frame and the right support frame are connected to the bottom plate by two hexagon socket combination screws.

[0017] (III) Beneficial effects

[0018] 1. The device of the present invention applies microfluidic chip technology and adopts a multi-channel design, which can realize customized detection services according to user needs, including cell culture, bacterial culture, organoid culture and protein crystallization.

[0019] 2. The device of the present invention has a compact structure, adopts the company's mature platform, has high reliability, can remotely control the operation of the device, can monitor the operating status of the instrument in real time, and can adapt to customized tasks such as bacterial culture, cell culture, protein crystallization, etc. in space. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The above description is only an overview of the technical solution of the present invention. In order to more clearly understand the technical means of the present invention and implement it according to the contents of the specification, the following is a detailed description of the preferred embodiments of the present invention in conjunction with the accompanying drawings.

[0021] Figure 1 Schematic diagram of the explosion of the internal device of the whole machine;

[0022] Figure 2 Schematic diagram of the explosion of the briquette assembly;

[0023] Figure 3 Explosion diagram of the piston push plate assembly;

[0024] Figure 4 Exploded diagram of optical module array assembly;

[0025] Figure 5 Explosion diagram of the three-motor drive module;

[0026] Figure 6 Perspective view of the internal device of the whole machine Figure 1 ;

[0027] Figure 7 Perspective view of the internal device of the whole machine Figure 2 ;

[0028] Figure 8 Schematic diagram of the working principle of chip filling reagents;

[0029] Fig. 9 Schematic diagram of the temperature control module explosion.

[0030] Legend: 1. Bottom plate; 2. Chip mounting base; 3. Side pressure plate; 4. Hexagon socket three-combination screw 1; 5. Microfluidic chip; 6. Polyurethane cushion; 700. Temperature control module; 8. Left support frame; 9. Hexagon socket two-combination screw 1; 10. Hexagon socket two-combination screw 2; 11. Chip upper pressure plate; 12. Hexagon socket two-combination screw 3; 13. Right support frame; 14. Hexagon socket two-combination screw 4; 15. Hexagon socket three-combination screw 2; 100. Screw nut motion assembly; 200. Piston Push plate assembly; 300, optical module array assembly; 400, three-motor drive module; 101, pressure block 1; 102, trapezoidal screw; 103, trapezoidal copper nut; 104, guide shaft 1; 105, hexagon socket two combination screws 5; 201, pressure block 2; 202, guide shaft 2; 203, screw nut; 204, hexagon socket three combination screws 3; 301, optical bracket; 302, optical module; 303, self-lubricating bushing 1; 304, hexagon socket two combination screws 6; 305, adapter ; 306, hexagon socket screw combination seven; 307, light baffle; 401, base; 402, self-lubricating bushing two; 403, 42 stepper motor; 404, coupling one; 405, hexagon socket screw combination eight; 406, encoder bracket one; 407, countersunk screw; 408, hexagon socket screw combination nine; 409, encoder; 410, encoder bracket two; 411, coupling two; 412, hexagon socket screw combination ten; 413, 57 stepper motor; 414, coupling 3; 415, two hexagon socket screws eleven; 416, end cover; 417, deep groove ball bearing; 418, encoder bracket three; 419, three hexagon socket screws four; 420, photoelectric sensor; 421, two hexagon socket screws twelve; 422, guide shaft three; 501, chip piston; 502, chip air hole cover; 701, heat transfer block; 702, temperature sensor; 703, heating film one; 704, thermal insulation foam one; 705, thermal insulation foam two; 706, heating film two. DETAILED DESCRIPTION

[0031] The embodiments of the present application provide an outer space biological payload device, which effectively solves the following problems that may exist in existing devices and make them unable to adapt to customized tasks such as bacterial culture, cell culture, protein crystallization, etc. in space: they may lack special designs for the space environment and cannot effectively simulate space environmental conditions such as microgravity, cosmic rays, heavy particles, and weak magnetic fields; they may not be able to meet the strict requirements of these tasks in terms of temperature, pressure, nutrient supply, and waste disposal; the automated full-process operation may not be accurate and efficient enough to ensure the smooth progress of the experiment; the remote control and real-time monitoring functions may be imperfect, and technical problems such as the inability to adjust and intervene in the experimental process in a timely manner may occur.

[0032] Example

[0033] like Figure 1-Figure 9 As shown, the technical solution in the embodiment of the present application effectively solves the following problems that the existing devices may have, which may lead to the inability to adapt to customized tasks such as bacterial culture, cell culture, protein crystallization, etc. in space: they may lack special designs for the space environment and cannot effectively simulate space environmental conditions such as microgravity, cosmic rays, heavy particles, and weak magnetic fields; they may not be able to meet the strict requirements of these tasks in terms of temperature, pressure, nutrient supply, and waste disposal; the automated full-process operation may not be accurate and efficient enough to ensure the smooth progress of the experiment; the remote control and real-time monitoring functions may be imperfect, and the experimental process cannot be adjusted and intervened in time. The overall idea is as follows:

[0034] In view of the problems existing in the prior art, the present invention provides an outer space biological payload device, including a bottom plate 1, a chip mounting base 2, and the outer space biological payload device is also provided with a remote control mechanism, a side pressure plate 3, a three-combination screw of an inner hexagon socket 4, a microfluidic chip 5, a polyurethane cushion 6, a temperature control module 700, a left support frame 8, a two-combination screw of an inner hexagon socket 9, a two-combination screw of an inner hexagon socket 10, a chip upper pressure plate 11, a two-combination screw of an inner hexagon socket 12, a right support frame 13, a two-combination screw of an inner hexagon socket 14, a three-combination screw of an inner hexagon socket 15, a screw nut motion assembly 100, a piston push plate assembly 200, an optical module array assembly 300, a three-motor drive module 400, a pressure block 101, and a ladder Screw rod 102, trapezoidal copper nut 103, guide shaft 104, hexagon socket two combination screws 5 105, pressure block 201, guide shaft 202, screw nut 203, hexagon socket three combination screws 3 204, optical bracket 301, optical module 302, self-lubricating sleeve 1 303, hexagon socket two combination screws 6 304, adapter 305, hexagon socket two combination screws 7 306, light baffle 307, base 401, self-lubricating sleeve 2 402, 42 stepper motor 403, coupling 1 404, hexagon socket two combination screws 8 405, encoder bracket 1 406, countersunk screw 407, hexagon socket two combination screws 9 408, encoder 409, encoder bracket 2 410, coupling 2 4 11. Two hexagon socket screws 10 412, 57 stepper motor 413, coupling 3 414, two hexagon socket screws 11 415, end cover 416, deep groove ball bearing 417, encoder bracket 3 418, three hexagon socket screws 4 419, photoelectric sensor 420, two hexagon socket screws 12 421, guide shaft 3 422, chip piston 501, chip vent cover 502, heat conduction block 701, temperature sensor 702, heating film 1 703, insulation foam 1 704, insulation foam 2 705, heating film 2 706, side pressure plate 3, microfluidic chip 5, connected to chip mounting base 2 through chip upper pressure plate 11 and polyurethane cushion 6, side pressure plate 3 supports the side of microfluidic chip 5 , the temperature control module 700 is arranged on the chip mounting base 2, the left support frame 8 and the right support frame 13 are respectively arranged on both sides of the bottom plate 1, the pressing block assembly 100 includes a pressing block 101, a trapezoidal screw 102, a trapezoidal copper nut 103, a guide shaft 104 and a hexagon socket two combination screw 5 105, the piston push plate assembly 200 includes a pressing block 201, a guide shaft 202, a screw nut 203 and a hexagon socket three combination screw 3 204, the optical module array assembly 300 includes an optical bracket 301, an optical module 302, a self-lubricating sleeve 1 303, a hexagon socket two combination screw 6 304, an adapter 305, a hexagon socket two combination screw 7 306 and a light baffle 307, and a three-motor drive module 400,It includes a base 401, a self-lubricating sleeve 2 402, a 42 stepper motor 403, a coupling 1 404, two hexagon socket screws 8 405, an encoder bracket 1 406, a countersunk screw 407, two hexagon socket screws 9 408, an encoder 409, an encoder bracket 2 410, a coupling 2 411, two hexagon socket screws 10 412, a 57 stepper motor 413, a coupling 3 414, two hexagon socket screws 11 415, an end cover 416, a deep groove ball bearing 417, an encoder bracket 3 418, three hexagon socket screws 419, a photoelectric sensor 420 and two hexagon socket screws 12 422, a pressing block assembly 100, a piston push plate assembly 200 and an optical module array assembly 300 are installed on the three-motor drive module 400. The middle piece 6 is formed on the upper surface of the left support frame 8 and the right support frame 13. The base 401 is locked with the left support frame 8 and the right support frame 13 by two hexagon socket combination screws 14. The two guide shafts 104 are pressed into the corresponding holes of the pressing block 101 on the press and put in place. Then the trapezoidal screw 102 and the trapezoidal nut 103 are assembled and placed on the upper surface of the pressing block 101. The through hole on the trapezoidal nut 103 is aligned with the threaded hole on the pressing block 101, and it is fastened with four hexagon socket combination screws 105. After the assembly is completed, the pressing block assembly 100 is formed. The device of the present invention uses microfluidic chip technology and adopts a multi-channel design. It can realize customized detection services according to user needs, including cell culture, bacterial culture, organoid culture and protein crystallization.

[0035] The temperature control module 700 includes a heat conductive block 701, a temperature sensor 702, a heating film 1 703, an insulating foam 1 704, an insulating foam 2 705 and a heating film 2 706. On a press, two guide shafts 202 are pressed into the corresponding holes of the pressing block 201 and are in place. The screw nut 203 is inserted into the corresponding hole of the pressing block 201 and the screw holes of the two are aligned. The two are fixed with three hexagon socket three-combination screws 204. After assembly, the piston pressure plate assembly 200 is formed. In the pressing block assembly 100, two guide shafts 104 are pressed into the corresponding holes of the pressing block 101, and a set of trapezoidal screws 102 and trapezoidal nuts 103 are assembled and placed on the upper surface of the pressing block 101. The through hole on the trapezoidal nut 103 is aligned with the threaded hole on the pressing block 101, and is fastened with four hexagon socket two-combination screws 5 105. Install the three optical modules 302 onto the optical bracket 301 with two hexagon socket screws 304 as shown in the figure, and complete the assembly to form the intermediate piece 1; use a press to press the self-lubricating sleeve 303 into the corresponding hole of the adapter 305, and then fix the light baffle 307 to the adapter 305 with two hexagon socket screws 304, install the screw nut 203 into the corresponding hole of the adapter 305 and align the screw holes of the two, and assemble the two together with three hexagon socket screws 204 to form the intermediate piece 2; and press the intermediate piece 1 and the intermediate piece 2 together. As shown in the figure, the fixing holes are aligned, and the two are assembled together with the hexagon socket combination screw 7 306 to form the optical module array assembly 300; the two guide shafts 202 are pressed into the corresponding holes of the pressing block 201, the screw nut 203 is inserted into the corresponding hole of the pressing block 201 and the screw holes of the two are aligned, and the two are fixed by three hexagon socket combination screws 3 204, and the temperature sensor 702 is inserted into the corresponding groove of the heat conductive block 701, and the groove is filled with thermal conductive silicone. After standing for a period of time, the thermal conductive silicone solidifies to fix the temperature sensor at the corresponding position in the groove.Tear off the adhesive protective films of heating film 1 703 and heating film 2 706, and install them flatly in the corresponding grooves; tear off the adhesive protective films of thermal insulation foam 1 704 and thermal insulation foam 2 705, stick thermal insulation foam 1 704 to the back of heating film 1 703, and stick thermal insulation foam 2 705 to the back of heating film 2 706. After assembly, the temperature control module 700 is formed. Use a press to press the guide shaft 3 422, all self-lubricating sleeves 2 402 and two deep groove ball bearings 417 into the corresponding holes of the base 401, and press As shown in the figure, the end cover 416 is installed on one side of the deep groove ball bearing 417, and the bearing is pressed with four hexagon socket two-piece combination screws 11 415 to complete the assembly of the middle piece 3; the coupling 1 404 is connected to the 42 stepper motor 403 to form the middle piece 4, and the coupling 2 411 and the coupling 3 414 are assembled on the two shaft ends of the 57 stepper motor 413 as shown in the figure to form the middle piece 5; the middle piece 4 is installed at 2 places as shown in the figure, and fastened with two hexagon socket two-piece combination screws 12 421; the middle piece 5 Install it at the corresponding position of the base 401 as shown in the figure, and fasten it with four hexagon socket two-combination screws 412; install the encoder bracket 1 406 at the corresponding position of the base 401 with countersunk screws 407, install the encoder bracket 2 410 at the corresponding position of the base 401 with two hexagon socket two-combination screws 408, and install the encoder bracket 3 418 at the corresponding position of the base 401 with two hexagon socket two-combination screws 408; install the encoder 409 at the corresponding positions of the encoder bracket 1 406, the encoder bracket 2 410 and the encoder bracket 3 418 respectively, and connect the encoder to each bracket with two hexagon socket two-combination screws 405; insert the encoder shaft into the coupling 1 404 and the coupling 2 411 holes respectively, tighten the screws on the above couplings, and clamp the encoder shaft; install the photoelectric sensor 420 on the base 401 with three hexagon socket three-combination screws 419, and the assembly is completed to form a three-motor drive module 400. The device of the present invention has a compact structure, adopts the company's mature platform, and has high reliability.

[0036] The guide shaft 3 422, all the self-lubricating sleeves 2 402 and two deep groove ball bearings 417 are pressed into the corresponding holes of the base 401, the end cover 416 is installed on one side of the deep groove ball bearing 417, and the bearing is pressed by four hexagon socket combination screws 11 415. The coupling 1 404 is connected with the 42 stepper motor 403 to form the middle piece 4, the coupling 2 411 and the coupling 3 414 are assembled on the two shaft ends of the 57 stepper motor 413 to form the middle piece 5, and the middle piece 4 is installed at 2 places respectively, through The middle piece 5 is fastened by two hexagon socket combination screws 12 421, and is installed at the corresponding position of the base 401. It is fastened by four hexagon socket combination screws 10 412. The encoder bracket 1 406 is installed at the corresponding position of the base 401 by countersunk screws 407. The encoder bracket 2 410 and the encoder bracket 3 418 are installed at the corresponding position of the base 401 by two hexagon socket combination screws 9 408. The encoder 409 is respectively installed at the corresponding positions of the encoder bracket 1 406, the encoder bracket 2 410 and the encoder bracket 3 418. The encoder is connected to each bracket by two hexagon socket combination screws 8 405. The rotating shaft of the encoder is respectively inserted into the holes of the coupling 1 404 and the coupling 2 411. The screws on the coupling are tightened to clamp the rotating shaft of the encoder. The photoelectric sensor 420 is installed on the base 401 by three hexagon socket combination screws 419. The chip mounting base 2 is placed at the corresponding position of the bottom plate 1 as shown in the figure, and the temperature control module 700 is placed at the corresponding position of the chip mounting base 2 , fasten with two hexagon socket combination screws 10; place three sets of microfluidic chips 5 in the corresponding grooves of the heat conductive block 701 respectively, and the other end of the bottom of the chip is close to the chip mounting base 2, and the polyurethane cushion 6 and the chip upper pressure plate 11 are placed on the upper surface of the microfluidic chip 5 in sequence, and the through holes of the chip upper pressure plate 11 are aligned with the corresponding screw holes of the chip mounting base 2 and the bottom plate 1, and fastened with two hexagon socket combination screws 12; the side pressure plate 3 supports the side of the microfluidic chip 5 and is fastened with three hexagon socket combination screws 4;The left support frame 8 and the right support frame 13 are respectively placed on both sides of the bottom plate 1 as shown in the figure, and then fastened with two hexagon socket combination screws 9. The chip mounting base 2 is connected to the temperature control module 700 through two hexagon socket combination screws 10. The three sets of microfluidic chips 5 are placed in the corresponding grooves of the heat conductive block 701. The other end of the bottom of the chip is tightly attached to the chip mounting base 2. The polyurethane cushion 6 and the chip upper pressure plate 11 are placed on the upper surface of the microfluidic chip 5 in sequence. The through holes of the chip upper pressure plate 11 are aligned with the corresponding screw holes of the chip mounting base 2 and the bottom plate 1, and are fastened with two hexagon socket combination screws 12. The side pressure plate 3 is fastened with three hexagon socket combination screws 4. Fasten, install the pressing block assembly 100, the piston pressure plate assembly 200 and the optical module array assembly 300 on the three-motor drive module 400 to form the middle piece 6, the left support frame 8 and the right support frame 13 are connected to the bottom plate 1 through two hexagon socket combination screws 9, and the middle piece 6 is placed on the upper surface of the left support frame 8 and the right support frame 13. The base 401 is aligned with the screw holes of the left support frame 8 and the right support frame 13, and locked with two hexagon socket combination screws 14. The device can be remotely controlled to run, the instrument operation status can be monitored in real time, and it can adapt to customized tasks such as bacterial culture, cell culture, protein crystallization, etc. in space. ;

[0037] Working principle:

[0038] There are three cylinders arranged at equal intervals on the pressure block 201, and the lower surface of the cylinder is a distance away from the chip piston 501. The remote control system drives the screw of the stepping motor 403 through the control board 42 to rotate and drive the screw nut 203 to move up and down. The screw nut 203 drives the pressure block 201 to move downward and push the chip piston 501 to squeeze the reagent in the piston cylinder. The reagent enters the reaction chamber of the microfluidic chip 5 through the microchannel. When the chip piston 501 is pressed down to the set position, its position is measured by the encoder 409 and measured by the remote control. The satellite network transmits the information back to the ground station, the embedded reagents completely enter the reaction chamber, the chip vent cover 502 of the microfluidic chip 5 is initially open, the remote control system controls the 57 stepper motor 413 to operate through the control panel, the protruding shaft at one end is connected to the trapezoidal screw 102 through the coupling 3 414, the trapezoidal screw 102 drives the trapezoidal nut 103 to move with the pressing block 101, the lower pressing surface of the pressing block 101 presses the three chip vent cover plates 502 at the same time and completely presses them, the 57 stepper motor 413 is actually The position is measured by the encoder 409 and transmitted back to the ground station through the remote satellite network. The control board controls the heating film 1 703 and the heating film 2 706 to energize to uniformly heat the heat conductive block 701. The reagent reacts or cultures at the set temperature. The 42 stepper motor 403 drives the optical module array assembly 300 to move horizontally. The optical module 302 reads the fluorescence value after the reaction in the reaction chamber of the microfluidic chip 5 in real time, analyzes and processes the fluorescence value through the light control board, and transmits the processing result back to the ground station through the remote satellite network. The growth status of the culture in the chip is transmitted back to the ground monitoring station in real time through the camera of the remote monitoring system. The device of the present invention applies microfluidic chip technology and adopts a multi-channel design. It can realize customized detection services according to user needs, including cell culture, bacterial culture, organoid culture and protein crystallization. The device of the present invention has a compact structure, adopts the company's mature platform, has high reliability, can remotely control the operation of the device, can monitor the operation status of the instrument in real time, and can adapt to customized tasks such as bacterial culture, cell culture, protein crystallization, etc. in space.

[0039] Finally, it should be noted that: Obviously, the above embodiments are only examples for clearly explaining the present invention, and are not intended to limit the implementation methods. For ordinary technicians in the relevant field, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived from this are still within the scope of protection of the present invention.

Claims

1. An outer space biological payload device, comprising a base plate (1) and a chip mounting base (2), characterized in that: The outer space biological payload device is also provided with a remote control mechanism, a side pressure plate (3), a hexagon socket three-combination screw one (4), a microfluidic chip (5), a polyurethane soft pad (6), a temperature control module (700), a left support frame (8), a hexagon socket two-combination screw one (9), a hexagon socket two-combination screw two (10), a chip upper pressure plate (11), a hexagon socket two-combination screw three (12), a right support frame (13), a hexagon socket two-combination screw four (14), a hexagon socket three-combination screw two (15), a screw nut motion assembly (100), and a piston push plate assembly Part (200), optical module array assembly (300), three-motor drive module (400), pressing block one (101), trapezoidal screw (102), trapezoidal copper nut (103), guide shaft one (104), hexagon socket two combination screw five (105), pressing block two (201), guide shaft two (202), screw nut (203), hexagon socket three combination screw three (204), optical bracket (301), optical module (302), self-lubricating sleeve one (303), hexagon socket two combination screw six (304), adapter (30 5), hexagon socket screw combination seven (306), light baffle (307), base (401), self-lubricating sleeve two (402), 42 stepper motor (403), coupling one (404), hexagon socket screw combination eight (405), encoder bracket one (406), countersunk screw (407), hexagon socket screw combination nine (408), encoder (409), encoder bracket two (410), coupling two (411), hexagon socket screw combination ten (412), 57 stepper motor (413), coupling three (41 4), two hexagon socket screws eleven (415), end cover (416), deep groove ball bearing (417), encoder bracket three (418), three hexagon socket screws four (419), photoelectric sensor (420), two hexagon socket screws twelve (421), guide shaft three (422), chip piston (501), chip vent cover (502), heat conduction block (701), temperature sensor (702), heating film one (703), thermal insulation foam one (704), thermal insulation foam two (705), heating film two (706); The side pressure plate (3) and the microfluidic chip (5) are connected to the chip mounting base (2) through the chip upper pressure plate (11) and the polyurethane cushion (6); the side pressure plate (3) supports the side of the microfluidic chip (5); the temperature control module (700) is arranged on the chip mounting base (2); the left support frame (8) and the right support frame (13) are respectively arranged on both sides of the bottom plate (1); the pressure block assembly (100) includes a pressure block (101), a trapezoidal screw rod (102), a trapezoidal copper nut (103), a guide shaft (104) and a hexagon socket Two combination screws five (105), a piston push plate assembly (200), including a pressure block two (201), a guide shaft two (202), a screw nut (203) and a hexagon socket three combination screw three (204), an optical module array assembly (300), including an optical bracket (301), an optical module (302), a self-lubricating sleeve one (303), a hexagon socket two combination screw six (304), an adapter (305), a hexagon socket two combination screw seven (306) and a light baffle (307), a three-motor drive module (400), including a base (401), a self Lubricating sleeve 2 (402), 42 stepper motor (403), coupling 1 (404), hexagon socket screw 8 (405), encoder bracket 1 (406), countersunk screw (407), hexagon socket screw 9 (408), encoder (409), encoder bracket 2 (410), coupling 2 (411), hexagon socket screw 10 (412), 57 stepper motor (413), coupling 3 (414), hexagon socket screw 11 (415), end cover (416), deep groove ball bearing (417), encoder The device bracket three (418), the hexagon socket three combination screw four (419), the photoelectric sensor (420) and the hexagon socket two combination screw twelve (422), the pressure block assembly (100), the piston push plate assembly (200) and the optical module array assembly (300) are installed on the three-motor drive module (400) to form an intermediate component 6, and the intermediate component 6 is placed as a whole on the upper surface of the left support frame (8) and the right support frame (13), and the base (401) and the left support frame (8) and the right support frame (13) are locked by the hexagon socket two combination screw four (14).

2. The outer space biological payload device according to claim 1, characterized in that: The temperature control module (700) comprises a heat conducting block (701), a temperature sensor (702), a heating film 1 (703), a thermal insulation foam 1 (704), a thermal insulation foam 2 (705) and a heating film 2 (706).

3. The outer space biological payload device according to claim 2, characterized in that: In the pressing block assembly (100), the two guide shafts (104) are pressed into the corresponding holes of the pressing block one (101), the trapezoidal screw rod (102) and the trapezoidal nut (103) are assembled and placed on the upper surface of the pressing block one (101), the through hole on the trapezoidal nut (103) is aligned with the threaded hole on the pressing block one (101), and are fastened by four hexagon socket combination screws five (105).

4. The outer space biological payload device according to claim 3, characterized in that: The two guide shafts (202) are pressed into the corresponding holes of the second pressing block (201), and the screw nut (203) is inserted into the corresponding hole of the second pressing block (201) and the screw holes of the two are aligned, and the two are fixed by three hexagon socket three combination screws (204).

5. The outer space biological payload device according to claim 4, characterized in that: The three optical modules (302) are mounted on the optical bracket (301) by means of the six hexagon socket combination screws (304), the self-lubricating sleeve (303) is pressed into the corresponding hole of the adapter (305), the light baffle (307) is fixed to the adapter (305) by means of the six hexagon socket combination screws (304), the screw nut (203) is installed in the corresponding hole of the adapter (305) and the screw holes of the two are aligned, and the two are assembled together by means of the three hexagon socket combination screws (204).

6. The outer space biological payload device according to claim 5, characterized in that: The guide shaft three (422), all the self-lubricating sleeves two (402) and the two deep groove ball bearings (417) are pressed into the corresponding holes of the base (401), the end cover (416) is installed on one side of the deep groove ball bearing (417), and the bearing is pressed by four hexagon socket combination screws eleven (415). The coupling one (404) is connected with the 42 stepping motor (403) to form an intermediate piece 4. The coupling two (411) and the coupling three (414) are assembled on the two shaft ends of the 57 stepping motor (413) to form an intermediate piece 5. The intermediate piece 4 is installed at 2 places respectively and fastened by the hexagon socket combination screws twelve (421). The intermediate piece 5 is installed at the corresponding position of the base (401) and fastened by four hexagon socket combination screws ten (412). The encoder bracket one ( The encoder bracket 406 is installed at the corresponding position of the base (401) through the countersunk screw (407), the encoder bracket 2 (410) and the encoder bracket 3 (418) are installed at the corresponding position of the base (401) through the two hexagon socket combination screws (408), the encoder (409) is respectively installed at the corresponding positions of the encoder bracket 1 (406), the encoder bracket 2 (410) and the encoder bracket 3 (418), the encoder is connected to each bracket through the two hexagon socket combination screws (405), the encoder shaft is respectively inserted into the coupling 1 (404) and the coupling 2 (411) holes, the screws on the coupling are tightened, and the encoder shaft is clamped, and the photoelectric sensor (420) is installed on the base (401) through the three hexagon socket combination screws (419).

7. The outer space biological payload device according to claim 6, characterized in that: The chip mounting base (2) is connected to the temperature control module (700) by means of two hexagon socket combination screws (10), three sets of the microfluidic chips (5) are placed in corresponding grooves of the heat conductive block (701), the other end of the bottom of the chip is in close contact with the chip mounting base (2), the polyurethane cushion (6) and the chip upper pressure plate (11) are placed on the upper surface of the microfluidic chip (5) in sequence, the through holes of the chip upper pressure plate (11) are aligned with the corresponding screw holes of the chip mounting base (2) and the bottom plate (1), and are fastened by two hexagon socket combination screws (12), and the side pressure plate (3) is fastened by three hexagon socket combination screws (4).

8. The outer space biological payload device according to claim 7, characterized in that: The left support frame (8) and the right support frame (13) are connected to the bottom plate (1) via two hexagon socket combination screws (9).