An ultrasonic atomization dye solution dispersion device and a slide staining system

Abstract

This application discloses an ultrasonic atomizing dye dispersion device and a slide staining system. The ultrasonic atomizing dye dispersion device includes an operating table and a spraying device. The operating table is provided with a spraying area, which has multiple slide platforms. The spraying device includes an injection unit and an atomizing unit. The atomizing unit includes a first adjusting part and an atomizer. The atomizer is movably disposed on the operating table. The first adjusting part drives the atomizer to move closer to or away from the injection unit. The injection unit can store and inject dye. The injection unit and the atomizer are connected. The atomizer atomizes the dye and sprays it onto the slides on the slide platforms.

Description

Technical Field

[0001] This application relates to the field of slide staining technology, and more specifically, to an ultrasonic atomizing dye dispersion device and a slide staining system. Background Technology

[0002] Slide staining is usually performed by injection or dropping. However, injection staining requires a large amount of staining solution, basically immersing the entire slide. Dropping, on the other hand, involves drawing up the staining solution with a needle and dropping it directly onto the slide. Due to surface tension, this results in a large droplet that is difficult to disperse.

[0003] Staining methods such as injection staining or drop staining often result in incomplete or uneven coverage of the specimen by the staining solution, which in turn affects the accuracy of the staining results or makes the results unrecognizable, leading to the direct disposal of the slide specimen.

[0004] Therefore, a new technical solution is needed to solve the problem of uneven staining of glass slides. Summary of the Invention

[0005] One objective of this application is to provide a new technical solution for an ultrasonic atomizing dye dispersion device.

[0006] According to a first aspect of this application, an ultrasonic atomizing dye dispersion device is provided, comprising an operating table and a spraying device; the operating table is provided with a spraying area having multiple glass slide stages; the spraying device includes an injection unit and an atomizing unit, the atomizing unit including a first adjusting part and an atomizer, the atomizer being disposed on the first adjusting part, the first adjusting part being movably disposed on the operating table, the first adjusting part driving the atomizer closer to or further away from the injection unit, the injection unit being capable of storing and injecting dye, the injection unit being connected to the atomizer, and the atomizer atomizing and spraying the dye onto the glass slides on the glass slide stages.

[0007] Optionally, the atomizer includes a liquid storage cylinder with openings at both ends, an atomizing plate inside the liquid storage cylinder, and an opening at the end of the liquid storage cylinder furthest from the glass slide for injecting the dye solution.

[0008] Optionally, the atomizing unit further includes a cleaning device disposed on the first adjusting part. The cleaning device includes a first driver, a first transmission assembly, and a connector. The first driver is disposed on the first adjusting part. The first transmission assembly is connected to the rotating end of the first driver, and the first driver drives the first transmission assembly to rotate. The connector is rotatably disposed on the first transmission assembly, and the first driver drives the connector to rotate through the first transmission assembly. The atomizer is disposed on the connector. When the first driver drives the first transmission assembly to rotate the connector, the connector drives the atomizer to rotate, causing the airflow direction ejected by the atomizer to switch between being perpendicular to the spraying area and parallel to the spraying area.

[0009] Optionally, the cleaning device further includes a limiting member, one end of which is connected to the connecting member. When the connecting member drives the limiting member to rotate to a preset angle, the other end of the limiting member forms a limiting engagement with the first transmission component.

[0010] Optionally, the first adjustment unit includes a bracket, a first X-axis assembly, a first Y-axis assembly, and a first Z-axis assembly. The bracket is disposed on the operating table, the first X-axis assembly is disposed on the bracket and located above the spraying area, the first Y-axis assembly is movably disposed on the first X-axis assembly and moves along a first direction, the first Z-axis assembly is movably disposed on the first Y-axis assembly and moves along a second direction, the atomizer is disposed on the first Z-axis assembly and moves along a third direction, wherein the first direction, the second direction, and the third direction are mutually perpendicular to each other, forming a three-dimensional space.

[0011] Optionally, the injection unit includes a second adjustment section, a sampling needle, and a dyeing solution area; the second adjustment section is disposed on the support and is located above the dyeing spray area; the sampling needle has a first end and a second end disposed opposite to each other, the first end being a sampling end, and the second end being connected to the second adjustment section, the second adjustment section being able to drive the sampling needle to move closer to or away from the nebulizer; the dyeing solution area is detachably disposed on the operating table, the dyeing solution area having multiple dyeing solution boxes, the second adjustment section being able to drive the sampling needle to draw dyeing solution from the dyeing solution boxes and inject the dyeing solution into the nebulizer.

[0012] Optionally, the second adjustment part has a collision avoidance device and a light sensor. The collision avoidance device contains a shielding member and an elastic member. The opposite ends of the elastic member abut against the shielding member and the inner wall of the collision avoidance device, respectively. The second end of the sampling needle passes through the collision avoidance device, and the elastic member is sleeved on the sampling needle. The shielding member is connected to the sampling needle. When the elastic member is in a first state, the shielding end of the shielding member is connected to the light sensor, and the light sensor is in a normal state. When the elastic member is in a second state, the shielding end of the shielding member is disengaged from the light sensor, and the light sensor is in a warning state. The compression amount of the elastic member in the first state is less than the compression amount of the elastic member in the second state.

[0013] Optionally, the injection unit includes a second adjustment section, which includes a second X-axis assembly, a second Y-axis assembly, and a second Z-axis assembly. The second X-axis assembly is disposed on the support and located above the spraying area. The second Y-axis assembly is movably disposed on the second X-axis assembly and moves along a first direction. The second Y-axis assembly is movably disposed on the second Z-axis assembly and moves along a second direction. The sampling needle is disposed on the second Z-axis assembly and moves along a third direction. The first direction, the second direction, and the third direction are mutually perpendicular to each other, forming a three-dimensional space.

[0014] According to a second aspect of this application, a slide staining system is provided, the slide staining system including a slide holder and an ultrasonic atomizing staining solution dispersion device as described above, the slide holder being disposed in the first adjustment section.

[0015] Optionally, the slide gripper and the atomizer are disposed on opposite sides of the first adjustment section, and the slide gripper is capable of loading or unloading the slide on the slide stage.

[0016] In this embodiment, the dye solution is extracted by the injection unit and injected into the atomization unit, which then atomizes the dye solution and sprays it onto the slide to be dyed. The atomized dye solution can evenly cover the slide, resulting in uniform dyeing and reducing inaccurate or unrecognizable dyeing results caused by uneven dyeing. Furthermore, atomizing the dye solution effectively reduces waste. Moreover, by providing a first adjustment unit, the atomizer can be moved above the designated slide to be dyed, thereby improving dyeing efficiency.

[0017] In addition, by setting up multiple slide stages in the dyeing area, multiple slides of the same batch can be dyed, improving dyeing efficiency. Furthermore, by setting up the dyeing area, it is easier to collect the waste liquid from the dyeing process, reducing cross-contamination and improving cleaning efficiency.

[0018] Other features and advantages of this application will become clear from the following detailed description of exemplary embodiments with reference to the accompanying drawings. Attached Figure Description

[0019] The accompanying drawings, which are incorporated in and form part of this specification, illustrate embodiments of the present application and, together with their description, serve to explain the principles of the present application.

[0020] Figure 1 This is a schematic diagram of the slide staining system in the embodiments of this application;

[0021] Figure 2 This is a schematic diagram of the slide staining system in the embodiments of this application from another angle;

[0022] Figure 3 This is a schematic diagram of the atomizing unit in the embodiments of this application;

[0023] Figure 4 yes Figure 3 Enlarged schematic diagram of the cleaning device in section A;

[0024] Figure 5 This is a schematic diagram of the slide holder in the embodiments of this application;

[0025] Figure 6 This is a schematic diagram of the liquid injection unit in the embodiments of this application;

[0026] Figure 7 This is a schematic diagram of the liquid injection unit from another angle in an embodiment of this application;

[0027] Figure 8 yes Figure 1 A partially enlarged schematic diagram of the anti-collision device in section B;

[0028] Figure 9 This is a schematic diagram of the operation table in an embodiment of this application;

[0029] Figure 10 This is a schematic diagram of the operating console from another angle in an embodiment of this application;

[0030] Figure 11 This is a schematic diagram of the structure of the spraying zone in an embodiment of this application.

[0031] Explanation of reference numerals in the attached figures:

[0032] 1-Operating table; 11-Dyeing area; 111-Slide stage;

[0033] 2-Dyeing device;

[0034] 21-Injection unit;

[0035] 211 Second adjustment unit; 2111 Second X-axis assembly; 2112 Second Y-axis assembly; 2113 Second Y-axis assembly;

[0036] 212 - Sample insertion needle; 2121 - First end; 2122 - Second end;

[0037] 213 - Dye solution area;

[0038] 214 - Collision Avoidance Device;

[0039] 215 - Light sensor;

[0040] 216 - Covering parts;

[0041] 217 - Elastic component;

[0042] 22-Atomizing unit;

[0043] 221-First adjustment part; 2211-Bracket; 2212-First X-axis assembly; 2213-First Y-axis assembly; 2214-First Z-axis assembly;

[0044] 222-Atomizer; 2221-Liquid reservoir; 2222-Atomizing plate;

[0045] 223-Cleaning device; 2231-First driver; 2232-First transmission assembly; 2233-Connector; 2234-Limiting element;

[0046] 3-Slide holder. Detailed Implementation

[0047] Various exemplary embodiments of the present application will now be described in detail with reference to the accompanying drawings. It should be noted that, unless otherwise specifically stated, the relative arrangement, numerical expressions, and values ​​of the components and steps set forth in these embodiments do not limit the scope of the present application.

[0048] The following description of at least one exemplary embodiment is merely illustrative and is in no way intended to limit the scope of this application and its application or use.

[0049] Techniques, methods, and equipment known to those skilled in the art may not be discussed in detail, but where appropriate, they should be considered part of the specification.

[0050] In all the examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values.

[0051] It should be noted that similar labels and letters in the following figures indicate similar items; therefore, once an item is defined in one figure, it does not need to be discussed further in subsequent figures.

[0052] According to one embodiment of this application, an ultrasonic atomizing dye dispersion device is provided. The ultrasonic atomizing dye dispersion device includes an operating table 1 and a spraying device 2; the operating table 1 is provided with a spraying area 11, the spraying area 11 having multiple glass slide stages 111; the spraying device 2 includes a liquid injection unit 21 and an atomizing unit 22, the atomizing unit 22 including a first adjusting part 221 and an atomizer 222, the atomizer 222 being disposed on the first adjusting part 221, the first adjusting part 221 being movably disposed on the operating table 1, the atomizer 222 of the first adjusting part 221 being close to or away from the liquid injection unit 21, the liquid injection unit 21 being capable of storing and injecting dye, the liquid injection unit 21 being connected to the atomizer 222, and the dye being atomized and sprayed onto the glass slides on the glass slide stages 111 through the atomizer 222.

[0053] like Figures 1 to 11 As shown, the operating table 1 is rectangular and has multiple legs at the bottom.

[0054] Of course, the operating table 1 in this embodiment is not limited to the structure described above, and those skilled in the art can configure it according to actual needs. For example, the operating table 1 may also be a box structure.

[0055] The dyeing zone 11 is a rectangular groove formed on the operating table 1. The dyeing zone 11 can be either a groove on the operating table 1 or a receiving pool set on the operating table 1. A slide stage 111 is provided within the dyeing zone 11 for placing slides. The slides to be dyed are fixed to the dyeing zone 11 by the slide stage 111. The dyeing device 2 dyes the slides with the dyeing solution. Waste liquid generated during the dyeing process is collected in the receiving pool. The bottom of the receiving pool has a drain outlet, through which the waste liquid can be discharged from the dyeing zone 11. This not only facilitates waste liquid cleaning but also effectively reduces cross-contamination of the slides to be dyed.

[0056] The dyeing device 2 includes a liquid injection unit 21 and an atomization unit 22. The liquid injection unit 21 is used to extract the dye liquid and inject it into the atomization unit 22, and the atomization unit 22 sprays the dye liquid onto the glass slide to be dyed.

[0057] The atomizing unit 22 includes a first adjusting section 221 and an atomizer 222. The atomizer 222 is disposed on the first adjusting section 221. The first adjusting section 221 drives the atomizer 222 to move above the dyeing area 11. The control system adjusts the first adjusting section 221 to move the atomizer 222 above the designated slide position. The dye solution is injected into the atomizer 222 by activating the liquid injection unit 21, and the activated atomizer 222 atomizes the dye solution to uniformly dye the slide to be stained.

[0058] Of course, the atomizer 222 in this embodiment is not limited to the structure described above, and those skilled in the art can configure it according to actual needs. For example, the atomizer 222 may be an atomizing nozzle or an atomizing plate 2222 or other atomizing device.

[0059] Compared to methods such as immersion and dripping, atomized spraying not only allows for uniform spraying of the slides to be stained, reducing inaccurate or unrecognizable staining results due to uneven staining, but also effectively reduces waste of dye solution.

[0060] In this embodiment, the dye solution is drawn by the injection unit 21 and injected into the atomization unit 22, so that the dye solution is atomized by the atomization unit 22 and sprayed onto the glass slide to be dyed. The atomized dye solution can evenly cover the glass slide to be dyed, so that the glass slide is dyed evenly, reducing the situation where the dyeing result is inaccurate or cannot be judged due to uneven dyeing of the glass slide. Moreover, by spraying the glass slide with the dye solution atomized, the waste of dye solution can also be effectively reduced. Furthermore, by setting the first adjustment part 221, the atomizer 222 can be moved above the designated glass slide to be dyed, so as to dye the designated glass slide, effectively improving the dyeing efficiency.

[0061] In addition, by setting multiple slide stages 111 in the dyeing zone 11, multiple slides of the same batch can be dyed, improving dyeing efficiency. Furthermore, by setting up the dyeing zone 11, it is convenient to collect the waste liquid from the dyeing process, reducing cross-contamination and improving cleaning efficiency.

[0062] In one example, the atomizer 222 includes a liquid reservoir 2221 with openings at both ends. An atomizing plate 2222 is disposed inside the liquid reservoir 2221, and the opening at the end of the liquid reservoir 2221 away from the glass slide is used to inject the dye solution.

[0063] like Figures 1 to 5 As shown, the atomizer 222 includes a conical liquid storage cylinder 2221. The liquid storage cylinder 2221 is a conical cylinder with a smaller bottom and a larger top. An opening is provided at the top of the liquid storage cylinder 2221 to facilitate the injection unit 21 to inject dye liquid into the liquid storage cylinder 2221 through the top opening, and also to facilitate the cleaning of the liquid storage cylinder 2221, reducing the chance of cross-contamination.

[0064] An atomizing plate 2222 is installed inside the liquid storage cylinder 2221. The atomizing plate 2222 is located inside the liquid storage cylinder 2221 and close to one end of the glass slide to facilitate the storage of dye solution above the atomizing plate 2222 inside the liquid storage cylinder 2221. Dye solution is injected into the liquid storage cylinder 2221 through the injection unit 21. When it is necessary to spray dye onto the glass slide, the atomizing plate 2222 is energized, and the atomizing plate 2222 is activated to atomize the dye solution and spray the atomized dye solution onto the glass slide to be dyed. When dyeing is not required, the atomizing plate 2222 is de-energized, and the atomizing plate 2222 stops operating, so the dye solution cannot be sprayed onto the glass slide through the atomizing plate 2222.

[0065] By setting an atomizing plate 2222 inside the liquid storage cylinder 2221, the atomization state can be controlled, and the waste of dye liquor can be reduced.

[0066] In one example, the atomizing unit 22 further includes a cleaning device 223, which is disposed on the first adjusting part 221. The cleaning device 223 includes a first driver 2231, a first transmission assembly 2232, and a connector 2233. The first driver 2231 is disposed on the first adjusting part 221. The first transmission assembly 2232 is connected to the rotating end of the first driver 2231, and the first driver 2231 drives the first transmission assembly 2232 to rotate. The connector 2233 is rotatably disposed on the first transmission assembly 2232, and the first driver 2231 drives the connector 2233 to rotate through the first transmission assembly 2232. The atomizer 222 is disposed on the connector 2233. When the first driver 2231 drives the first transmission assembly 2232 to rotate the connector 2233, the connector 2233 drives the atomizer 222 to rotate, causing the airflow direction ejected by the atomizer 222 to switch between perpendicular to the spraying area 11 and parallel to the spraying area 11.

[0067] like Figures 1 to 5 As shown, the atomizer 222 is connected to the cleaning device 223, which is located in the first adjustment section 221. The first adjustment section 221 drives the cleaning device 223 to move to the cleaning area, and the cleaning device 223 causes the atomizer 222 to rotate, so that the atomizer 222 can be cleaned in the cleaning area. Cleaning the atomizer 222 can effectively reduce cross-contamination of dyeing liquid.

[0068] The cleaning device 223 includes a first driver 2231, which is a rotary motor. The first transmission assembly 2232 includes a drive gear, a conveyor belt, and a driven gear. The drive gear is located at the rotating end of the rotary motor and is connected to the driven gear via the conveyor belt. The connecting member 2233 is L-shaped, with the top of its long plate connected to the driven wheel, and the atomizer 222 is mounted on the short plate of the connecting member 2233. When the atomizer 222 needs cleaning, the cleaning device 223 and the atomizer 222 are moved to a cleaning area via a first adjusting part 221. The cleaning area has a first cleaning pool, where clean water is used to rinse away any residual dye in the atomizer 222.

[0069] When the first driver 2231 is started, the driving gear drives the driven gear to rotate through the conveyor belt, which causes the connector 2233 to drive the atomizer 222 to rotate. The rotation of the conical liquid storage tank 2221 causes the clean water in the cleaning area to rinse the inside of the liquid storage tank 2221, thereby cleaning the liquid storage tank 2221 and reducing the chance of cross-contamination of dye liquid.

[0070] Both the dyeing zone 11 and the cleaning zone are located on the operating table 1. The airflow from the atomizer 222 is perpendicular to the dyeing zone 11, meaning the nozzle of the atomizer 222 is vertical. The clean water in the cleaning zone is stored in the liquid storage tank 2221. The airflow from the atomizer 222 is parallel to the dyeing zone 11, meaning the nozzle of the atomizer 222 is horizontal. The water or dye solution stored in the liquid storage tank 2221 is poured out. Setting the liquid storage tank 2221 in a conical shape also facilitates the removal of residual liquid from the tank, effectively reducing the chance of cross-contamination.

[0071] In one example, the cleaning device 223 further includes a limiting member 2234, one end of which is connected to the connecting member 2233. When the connecting member 2233 drives the limiting member 2234 to rotate to a preset angle, the other end of the limiting member 2234 forms a limiting engagement with the first transmission component 2232.

[0072] like Figures 1 to 5 As shown, the rotating end of the first driver 2231 is connected to the drive gear via a connecting rod. A baffle is provided on the connecting rod. The baffles are arranged radially around the axis of the connecting rod.

[0073] The cleaning device 223 also includes a limiting member 2234, which limits the rotation angle of the connecting member 2233. One end of the limiting member 2234 is connected to the connecting member 2233 and is located near the driven gear. The limiting member 2234 has a notch that fits into a baffle. The limiting member 2234 and the connecting member 2233 are detachably connected. For example, if the rotation angle of the atomizer 222 is set to 90°, when the connecting member 2233 drives the atomizer 222 and the limiting member 2234 to rotate to 90°, the notch of the limiting member 2234 and the baffle form a limiting engagement to lock the connecting rod. Alternatively, the rotation angle of the atomizer 222 can be set to 180°, and the position of the limiting member 2234 on the connector 2233 can be adjusted. When the connector 2233 drives the atomizer 222 and the limiting member 2234 to rotate to 180°, the notch of the limiting member 2234 and the baffle form a limiting engagement to lock the connecting rod.

[0074] By limiting the rotation angle of the connector 2233, the rotation angle of the atomizer 222 is also limited, preventing the uncleaned waste liquid from re-entering the storage tank 2221 due to excessive rotation angle, thus avoiding secondary pollution.

[0075] In one example, the atomizing unit 22 further includes a first cleaning tank disposed on the operating table 1. The atomizer 222 is moved to the first cleaning tank by the first adjusting part 221 and driven to rotate by the first driver 2231, so that the direction of the airflow ejected by the atomizer 222 switches between perpendicular to the first cleaning tank and parallel to the first cleaning tank.

[0076] like Figure 1 , Figure 2 , Figures 9 to 10 As shown, the operating table 1 has a cleaning area, and the cleaning area has a first cleaning tank. The clean water in the first cleaning tank is used to clean the residual dye liquid in the atomizer 222.

[0077] The atomizing unit 22 also includes a first cleaning tank, which is installed on the operating table 1 and located on one side of the spraying area 11 to facilitate cleaning of the atomizer 222.

[0078] The atomizer 222 is moved to the first cleaning tank via the first adjustment unit 221. The cleaning device 223 drives the atomizer 222 to rotate, so as to use the clean water in the first cleaning tank to rinse the residual liquid in the atomizer 222. When the atomizer 222 is in a vertical position, it is filled with clean water from the first cleaning tank. The first driver 2231 rotates the atomizer 222 to be parallel to the first cleaning tank, that is, the atomizer 222 is in a horizontal position. The water and residual liquid in the liquid storage cylinder 2221 are poured out. The above steps are repeated to rinse and clean the residual liquid in the atomizer 222, reducing cross-contamination.

[0079] In one example, the first adjustment unit 221 includes a bracket 2211, a first X-axis assembly 2212, a first Y-axis assembly 2213, and a first Z-axis assembly 2214. The bracket 2211 is disposed on the operating table 1, the first X-axis assembly 2212 is disposed on the bracket 2211 and is located above the spraying area 11, the first Y-axis assembly 2213 is movably disposed on the first X-axis assembly 2212 and moves along a first direction, the first Z-axis assembly 2214 is movably disposed on the first Y-axis assembly 2213 and moves along a second direction, and the atomizer 222 is disposed on the first Z-axis assembly 2214 and moves along a third direction. The first direction, the second direction, and the third direction are mutually perpendicular to each other, forming a three-dimensional space.

[0080] like Figures 1 to 8 As shown, bracket 2211 is a gantry frame installed on the operating table 1. The crossbeam of the gantry frame is located above the dyeing area 11. The first direction is the length direction of the operating table 1, the second direction is the width direction of the operating table 1, and the third direction is the height direction of the operating table 1.

[0081] The first X-axis assembly 2212 includes a second driver, a first drive wheel, and a first conveyor belt mounted on a gantry. The second driver is a rotary motor. The second driver and the first drive wheel are positioned relative to each other on the gantry, and the first conveyor belt is connected to the rotating end of the second driver and the first drive wheel, respectively. The first conveyor belt is arranged along the length of the rectangular operating table 1.

[0082] The first Y-axis assembly 2213 includes a mounting plate, a third driver, a second drive wheel, and a second conveyor belt. The third driver is a rotary motor. The third driver and the second drive wheel are positioned relative to each other on the mounting plate, and the second conveyor belt is connected to the rotating end of the third driver and the second drive wheel, respectively.

[0083] The top of the mounting plate is connected to the first conveyor belt, and the second driver drives the first conveyor belt to move along the length of the rectangular operating table 1.

[0084] The first Z-axis assembly 2214 includes a first slider, a first lead screw assembly, and a first mounting block. The first slider is connected to the second conveyor belt, the first lead screw assembly is mounted on the first slider, the first mounting block is connected to the first lead screw assembly, and the cleaning device 223 is mounted on the first mounting block.

[0085] The second conveyor belt is driven by the third driver to move the first Z-axis assembly 2214 along the width direction of the rectangular operating table 1. The position of the first mounting block is adjusted by the first lead screw assembly to move the atomizer 222 along the height direction of the rectangular operating table 1.

[0086] The position of the atomizer 222 along the length of the operating table 1 can be adjusted by the first X-axis assembly 2212, the position of the atomizer 222 along the width of the operating table 1 can be adjusted by the first Y-axis assembly 2213, and the height of the atomizer 222 from the slide on the operating table 1 can be adjusted by the first Z-axis assembly 2214. The first adjustment unit 221 can not only adjust the position of the atomizer 222 relative to the slide to effectively spray dye onto a designated slide and reduce dye waste, but also adjust the position of the atomizer 222 relative to the injection unit 21. For example, when the injection unit 21 is in a fixed position on the operating table 1, the first adjustment unit 221 can move the atomizer 222 closer to the injection unit 21 to facilitate the injection of dye into the atomizer 222.

[0087] Of course, the first adjustment part 221 in this application embodiment is not limited to the above structure, and those skilled in the art can make settings according to actual needs.

[0088] In one example, the injection unit 21 includes a second adjustment section 211, a sampling needle 212, and a dyeing solution area 213; the second adjustment section 211 is disposed on the support 2211 and is located above the spray dyeing area 11; the sampling needle 212 has a first end 2121 and a second end 2122 disposed opposite to each other, the first end 2121 is a sampling end, and the second end 2122 is connected to the second adjustment section 211, the second adjustment section 211 can drive the sampling needle 212 to move closer to or away from the nebulizer 222; the dyeing solution area 213 is detachably disposed on the operating table 1, the dyeing solution area 213 has multiple dyeing solution boxes, the second adjustment section 211 can drive the sampling needle 212 to draw dyeing solution from the dyeing solution boxes and inject the dyeing solution into the nebulizer 222.

[0089] like Figures 1 to 8 As shown, the second adjustment section 211 is disposed on the support 2211 and is movable along the length of the rectangular operating table 1. The second adjustment section 211 is located above the operating table 1 and above the dyeing area 11. The dye solution area 213 is disposed on the operating table 1 and located on one side of the dyeing area 11. The sampling needle 212 is disposed on the second adjustment section 211. The second adjustment section 211 drives the sampling needle 212 to move, draw the dye solution in the dye solution area 213, bring the drawn dye solution close to the atomizing unit 22, and inject the dye solution into the atomizer 222 so as to stain the slide to be stained through the atomizer 222.

[0090] The sampling needle 212 is tubular, with its bottom end 2121, the sampling end, and its top end 2122. The second end 2122 is connected to the second adjustment unit 211. The second adjustment unit 211 moves the sampling needle 212 to extract dye from the dye solution area 213 or inject the extracted dye into the nebulizer 222.

[0091] like Figures 9 to 10 As shown, the dyeing solution area 213 includes a dispensing hole and a dyeing solution tank on the operating table 1. The dyeing solution tank is a pull-out type and embedded in the operating table 1, and the dispensing hole on the upper surface of the operating table 1 is to facilitate the insertion of the sampling needle 212 into the dyeing solution area 213 to extract the dyeing solution.

[0092] The liquid dispensing box has multiple liquid storage chambers. By setting multiple liquid storage chambers, different dye solutions can be stored to adapt to different needs of the glass slides to be stained.

[0093] The liquid dispensing box has a handle for easy pushing, pulling or pulling out, pushing the liquid dispensing box into the operating table 1, or pulling out the liquid dispensing box when it is necessary to add dye solution.

[0094] A positioning device is provided at the end of the liquid collection box opposite to the handle. The positioning device is magnetically embedded in the operating table 1 to facilitate the installation of the liquid collection box in place, so that the liquid storage chamber can be accurately positioned, improve the sampling accuracy of the sampling needle 212, and reduce the occurrence of damage to the sampling needle 212 due to misalignment.

[0095] Of course, the liquid collection box in this embodiment is not limited to the structure described above, and those skilled in the art can configure it according to actual needs. For example, the positioning device can also be an interlocking device.

[0096] In one example, the second adjustment unit 211 has a collision avoidance device 214 and a light sensor 215. The collision avoidance device 214 is provided with a shielding member 216 and an elastic member 217. The opposite ends of the elastic member 217 abut against the shielding member 216 and the inner wall of the collision avoidance device 214, respectively. The second end 2122 of the sampling needle 212 passes through the collision avoidance device 214, and the elastic member 217 is sleeved on the sampling needle 212. The shielding member 216 is connected to the sampling needle 212. When the elastic member 217 is in a first state, the shielding end of the shielding member 216 is connected to the light sensor 215, and the light sensor 215 is in a normal state. When the elastic member 217 is in a second state, the shielding end of the shielding member 216 is disengaged from the light sensor 215, and the light sensor 215 is in a warning state. In the first state, the compression of the elastic member 217 is less than the compression of the elastic member 217 in the second state.

[0097] like Figures 6 to 8 As shown, the second adjuster is equipped with a bumper 214 and a light sensor 215. The bumper 214 is block-shaped and has a notch, at which a removable retaining plate is installed. The retaining plate, the bumper 214, and the second adjuster 211 are connected so that the notch forms a buffer space.

[0098] A blocking element 216 and an elastic element 217 are provided within the notch. The elastic element 217 is a spring. The blocking element 216 is L-shaped. The top of the blocking element 216 is connected to the bottom of the spring, and the top of the spring is connected to the lower surface of the retaining plate.

[0099] The top of the sampling needle 212 passes through the opening and sequentially through the shield 216, the spring, and the retaining plate. The shield 216 is connected to the sampling needle 212, and the spring and retaining plate are movably connected to the sampling needle 212.

[0100] For example, when the second adjusting part 211 moves the sampling needle 212 to the dye solution area 213 to draw dye solution, if there is insufficient dye solution in the storage chamber, or if the sampling end of the sampling needle 212 is misaligned with the dye solution area 213, causing the sampling needle 212 to puncture a hard object, or if the descent position is too low, the second adjusting part 211 continues to press down, and the sampling needle 212 moves upward. At this time, the blocking member 216 moves upward with the sampling needle 212, the spring is gradually compressed, and the short plate of the blocking member 216 gradually disengages from the light sensor 215. When the short plate of the blocking member 216 disengages from the light sensor 215, the light sensor 215 activates to issue a warning, reminding the user to add dye solution, and simultaneously sends a signal to the control system, causing the second adjusting part 211 to stop moving downward to protect the sampling needle 212. As the second adjustment section 211 rises, the spring gradually returns to its original state, supporting the shield 216 downwards, and simultaneously driving the sample needle 212 downwards to return to its original state, until the short plate of the shield 216 is connected to the light sensor 215, and the light sensor 215 stops issuing warnings.

[0101] The sampling needle 212 draws up the dye solution: The control system moves the second adjustment unit 211 above the dye solution area 213, and the sampling needle 212 moves down to the bottom of the storage chamber, aligned with the through hole. The sampling needle 212 has a liquid level detection function. If the sampling needle 212 does not contact the liquid surface, it means that the dye solution in this storage chamber has been used up and needs to be replaced. The software will issue an alarm prompt to replace or add dye solution. If the sampling needle 212 detects that there is enough dye solution, it will start the plunger pump, draw up a quantitative amount of dye solution through the sampling needle 212, and move it upward out of the dye solution area 213.

[0102] The dye solution is transferred to the nebulizer 222: The first adjustment unit 221 of the control system moves the nebulizer 222 above the set glass slide, and the second adjustment unit 211 moves the sampling needle 212 above the designated liquid storage chamber and takes liquid. The sampling needle 212 moves to the top of the nebulizer 222. By reversing the stopper pump, the dye solution stored in the sampling needle 212 is injected into the nebulizer 222. The second adjustment unit 211 moves the sampling needle 212 back to the original position.

[0103] In one example, the second cleaning tank is located on the operating table 1, and the second adjustment unit 211 can drive the sampling needle 212 to be cleaned in the second cleaning tank.

[0104] like Figure 1 , Figure 2 , Figure 9 and Figure 10 As shown, the operating table 1 also has a second cleaning tank. The second cleaning tank is arranged opposite to the first cleaning tank and is located on the side closer to the dye solution area 213.

[0105] The second cleaning tank is the cleaning tank of the liquid injection unit 21. The second adjustment unit 211 drives the sampling needle 212 to move to the second cleaning tank, and the sampling needle 212 draws clean water in the second cleaning tank for cleaning to reduce cross-contamination.

[0106] In one example, the injection unit 21 includes a second adjustment section 211, which includes a second X-axis assembly 2111, a second Y-axis assembly 2112, and a second Z-axis assembly 2113. The second X-axis assembly 2111 is disposed on the support and located above the spraying area 11. The second Y-axis assembly 2112 is movably disposed on the second X-axis assembly 2111 and moves along a first direction. The second Z-axis assembly 2113 is movably disposed on the second Y-axis assembly 2112 and moves along a second direction. The sampling needle 212 is disposed on the second Z-axis assembly 2113 and moves along a third direction. The first direction, the second direction, and the third direction are mutually perpendicular, forming a three-dimensional space.

[0107] like Figures 1 to 2 As shown, bracket 2211 is a gantry frame installed on the operating table 1. The crossbeam of the gantry frame is located above the dyeing area 11. The first direction is the length direction of the operating table 1, the second direction is the width direction of the operating table 1, and the third direction is the height direction of the operating table 1.

[0108] like Figures 1 to 7As shown, the second X-axis assembly 2111 includes a fourth driver, a third drive wheel, and a third conveyor belt mounted on the gantry. The fourth driver is a rotary motor. The fourth driver and the third drive wheel are positioned relative to each other on the gantry, and the third conveyor belt is connected to the rotating end of the fourth driver and the third drive wheel respectively. The third conveyor belt is arranged along the length of the rectangular operating table 1.

[0109] The second Y-axis assembly 2112 includes a mounting plate, a fifth driver, a fourth drive wheel, and a fourth conveyor belt. The fifth driver is a rotary motor. The fifth driver and the fourth drive wheel are positioned relative to each other on the mounting plate, and the fourth conveyor belt is connected to the rotating end of the fifth driver and the fourth drive wheel, respectively.

[0110] The top of the mounting plate is connected to the third conveyor belt, and the fourth driver drives the third conveyor belt to move the mounting plate along the length of the rectangular operating table 1.

[0111] The second Z-axis assembly 2113 includes a second slider, a second lead screw assembly, and a second mounting block. The second slider is connected to the fourth conveyor belt, the second lead screw assembly is mounted on the second slider, the second mounting block is connected to the second lead screw assembly, and a collision avoidance device 214 and a light sensor 215 are mounted on the second mounting block.

[0112] The fourth conveyor belt is driven by the fifth driver to move the second Z-axis assembly 2113 along the width direction of the rectangular operating table 1. The position of the second mounting block is adjusted by the second lead screw assembly to move the atomizer 222 along the height direction of the rectangular operating table 1.

[0113] The position of the dispensing needle 212 along the length of the operating table 1 can be adjusted by the second X-axis assembly 2111, the position of the dispensing needle 212 along the width of the operating table 1 can be adjusted by the second Y-axis assembly 2112, and the height of the dispensing needle 212 from the slide on the operating table 1 can be adjusted by the second Z-axis assembly 2113. The second adjustment unit 211 not only adjusts the position of the dispensing needle 212 relative to the slide to ensure precise dispensing of the nebulizer 222 and reduce waste of dye solution and slide contamination, but also adjusts the position of the dispensing needle 212 relative to the nebulizer 222. For example, the position between the nebulizer 222 and the slide can be adjusted first, and then the second adjustment unit 211 can be used to move the dispensing needle 212 to draw dye solution and move it to the position of the nebulizer 222 for dispensing.

[0114] Of course, the second adjustment unit 211 in this embodiment is not limited to the above structure, and those skilled in the art can make it according to actual needs.

[0115] According to another embodiment of this application, a slide staining system is provided, which includes a slide holder 3 and an ultrasonic atomizing staining solution dispersion device as described above, wherein the slide holder 3 is disposed in the first adjustment part 221.

[0116] like Figures 1 to 11 As shown, this ultrasonic atomizing dye dispersion device is suitable for slide staining systems. The slide to be stained is placed on the slide stage 111 by the slide holder 3. The stained slide can also be removed and sealed by the slide holder 3. This not only effectively reduces the intensity of manual labor, but also protects the unsealed stained slide, reducing contamination of the stained slide and affecting the accuracy of the staining results.

[0117] In one example, the slide holder 3 and the atomizer 222 are disposed on opposite sides of the first adjustment part 221, and the slide holder 3 is capable of loading or unloading the slide on the slide stage 111.

[0118] like Figures 1 to 5 As shown, the slide holder 3 and the atomizer 222 are respectively disposed on opposite sides of the first adjustment section 221. By placing the slide holder 3 in the first adjustment section 221, the first adjustment section 221 can be fully utilized, reducing the number of system components and lowering the difficulty of operation. Moreover, the slide holder 3 can be used to load or unload the slides on the slide stage 111, improving the automation level of the slide staining system.

[0119] like Figure 11 As shown, the slide stage 111 is provided with a locking part, which limits the position of the slide on the slide stage 111 to prevent the slide from moving during the staining process and affecting the staining effect.

[0120] This application uses a sampling needle 212 to draw a quantitative amount of dye solution, which is then added to an ultrasonic nebulizer 222 (maximum 3 ml). The dye solution is atomized by the ultrasonic nebulizing plate 2222 at the bottom of the nebulizer 222, and the control system evenly sprays the dye solution onto the entire glass slide.

[0121] Ultrasonic atomization process: In the programmed staining procedure, the control system causes the second adjustment unit 211 to drive the sampling needle 212 to the designated storage chamber to draw up the amount of staining solution. Then, the second adjustment unit 211 drives the sampling needle 212 back to the position docked with the first adjustment unit 221. The first adjustment unit 221 drives the nebulizer 222 to the position docked with the second adjustment unit 211. With the sampling needle 212 above the nebulizer 222, the staining solution in the sampling needle 212 is transferred to the nebulizer 222. Then, the ultrasonic atomizing plate 2222 converts the staining solution into a mist, which is evenly sprayed to cover the specimen on the glass slide.

[0122] This application has a simple structure and is easy to operate, enabling rapid and uniform atomization and spraying of dye onto the entire glass slide.

[0123] While specific embodiments of this application have been described in detail by way of examples, those skilled in the art should understand that the above examples are for illustrative purposes only and are not intended to limit the scope of this application. Those skilled in the art should understand that modifications can be made to the above embodiments without departing from the scope and spirit of this application. The scope of this application is defined by the appended claims.

Claims

1. An ultrasonic atomizing dye liquor dispersion device, characterized in that, include: An operating table (1) is provided with a spraying area (11), and the spraying area (11) has multiple glass slide stages (111). The spray dyeing device (2) includes a liquid injection unit (21) and an atomizing unit (22). The atomizing unit (22) includes a first adjustment part (221) and an atomizer (222). The atomizer (222) is disposed on the first adjustment part (221). The first adjustment part (221) is movably disposed on the operating table (1). The first adjustment part (221) drives the atomizer (222) to move closer to or away from the liquid injection unit (21). The liquid injection unit (21) can store and inject dye liquid. The liquid injection unit (21) is connected to the atomizer (222). The atomizer (222) atomizes the dye liquid and sprays it onto the glass slide on the slide stage (111). The atomizer (222) includes a liquid storage cylinder (2221), with openings at both ends of the liquid storage cylinder (2221). An atomizing plate (2222) is disposed inside the liquid storage cylinder (2221), and the opening at the end of the liquid storage cylinder (2221) away from the glass slide is used to inject the dye solution. The atomizing unit (22) further includes a cleaning device (223), which is disposed on the first adjusting part (221). The cleaning device (223) includes: The first driver (2231) is disposed on the first adjustment unit (221); The first transmission component (2232) is connected to the rotating end of the first driver (2231), and the first driver (2231) drives the first transmission component (2232) to rotate. A connector (2233) is rotatably mounted on the first transmission assembly (2232). The first driver (2231) drives the connector (2233) to rotate through the first transmission assembly (2232). The atomizer (222) is mounted on the connector (2233). When the first driver (2231) drives the first transmission assembly (2232) to rotate the connector (2233), the connector (2233) drives the atomizer (222) to rotate, so that the direction of the airflow ejected by the atomizer (222) switches between perpendicular to the dyeing area (11) and parallel to the dyeing area (11); The first adjustment unit (221) includes a bracket (2211), a first X-axis assembly (2212), a first Y-axis assembly (2213), and a first Z-axis assembly (2214). The bracket (2211) is disposed on the operating table (1). The first X-axis assembly (2212) is disposed on the bracket (2211) and is located above the spraying area (11). The first Y-axis assembly (2213) is movably disposed on the first X-axis assembly (2212) and moves along a first direction. The first Z-axis assembly (2214) is movably disposed on the first Y-axis assembly (2213) and moves along a second direction. The atomizer (222) is disposed on the first Z-axis assembly (2214) and moves along a third direction. Wherein, the first direction, the second direction, and the third direction are mutually perpendicular to each other, forming a three-dimensional space; The injection unit (21) includes: The second adjustment part (211) is disposed on the bracket (2211) and is located above the dyeing area (11); The sample dispensing needle (212) has a first end (2121) and a second end (2122) arranged opposite to each other. The first end (2121) is the sampling end, and the second end (2122) is connected to the second adjustment part (211). The second adjustment part (211) can drive the sample dispensing needle (212) to move closer to or away from the nebulizer (222). The dyeing solution area (213) is detachably mounted on the operating table (1). The dyeing solution area (213) has multiple dyeing solution boxes. The second adjustment unit (211) can drive the sampling needle (212) to draw dyeing solution from the dyeing solution box and inject the dyeing solution into the nebulizer (222).

2. The ultrasonic atomizing dye dispersion device according to claim 1, characterized in that, The cleaning device (223) also includes a limiting member (2234), one end of which is connected to the connecting member (2233). When the connecting member (2233) drives the limiting member (2234) to rotate to a preset angle, the other end of the limiting member (2234) forms a limiting engagement with the first transmission assembly (2232).

3. The ultrasonic atomizing dye dispersion device according to claim 1, characterized in that, The second adjustment part (211) has a collision avoidance device (214) and a light sensor (215). The collision avoidance device (214) is provided with a shield (216) and an elastic member (217). The opposite ends of the elastic member (217) abut against the shield (216) and the inner wall of the collision avoidance device (214) respectively. The second end (2122) of the sampling needle (212) passes through the collision avoidance device (214), and the elastic member (217) is sleeved on the sampling needle (212). The shield (216) is connected to the sampling needle (212). When the elastic member (217) is in the first state, the blocking end of the blocking member (216) is connected to the light sensor (215), and the light sensor (215) is in a normal state. When the elastic member (217) is in the second state, the blocking end of the blocking member (216) is disconnected from the light sensor (215), and the light sensor (215) is in an alarm state. Wherein, the compression amount of the first state elastic element (217) is less than the compression amount of the second state elastic element (217).

4. The ultrasonic atomizing dye dispersion device according to claim 3, characterized in that, The injection unit (21) includes a second adjustment section (211), which includes a second X-axis assembly (2111), a second Y-axis assembly (2112), and a second Z-axis assembly (2113). The second X-axis assembly (2111) is disposed on the support (2211) and is located above the spraying area (11). The second Y-axis assembly (2112) is movably disposed on the second X-axis assembly (2111) and moves along a first direction. The second Z-axis assembly (2113) is movably disposed on the second Y-axis assembly (2112) and moves along a second direction. The sampling needle (212) is disposed on the second Z-axis assembly (2113) and moves along a third direction. The first direction, the second direction, and the third direction are all perpendicular to each other, forming a three-dimensional space.

5. A slide staining system, characterized in that, Includes a slide holder (3) and an ultrasonic atomizing dye dispersion device as described in any one of claims 1-4, wherein the slide holder (3) is disposed in the first adjustment unit (221).

6. The slide staining system according to claim 5, characterized in that, The slide picker (3) and the atomizer (222) are located on opposite sides of the first adjustment part (221). The slide picker (3) can load or unload the slides on the slide stage (111).

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