Full-automatic solid-phase extraction alarm device

Abstract

According to the full-automatic solid-phase extraction alarm device, a first space is formed in a shell, a plurality of solvent bottles which are sequentially distributed in the first direction are arranged in the first space, solvent guide pipes are inserted into the tops of the solvent bottles, one ends of the solvent guide pipes extend and penetrate out of the first space, and the other ends of the solvent guide pipes extend to the bottoms in the solvent bottles; the alarm mechanism comprises a sensing assembly arranged outside each solvent bottle, and each sensing assembly is used for monitoring the liquid level change of the solvent in the corresponding solvent bottle in real time and triggering an alarm signal indicating that the liquid level in the corresponding solvent bottle is low when the liquid level is lower than a set sensing area. Through the sensing assembly arranged outside each solvent bottle, the liquid level change of the solvent can be accurately monitored in real time. Once the liquid level is lower than a set sensing area, an alarm signal is triggered immediately to inform an operator to add a solvent in time, so that experiment interruption caused by insufficient solvent is avoided, the continuity and success rate of an experiment are greatly improved, and the manpower monitoring cost and the error risk are reduced.

Description

Technical Field

[0001] The present application relates to the technical field of fully automatic solid phase extraction, and in particular to a fully automatic solid phase extraction alarm device. Background Art

[0002] In the existing field of fully automatic solid phase extraction technology, traditional devices have the following defects. Liquid level monitoring of solvent bottles mostly relies on manual observation, and operators need to frequently check the remaining solvent in the solvent bottle, which is not only labor-intensive, but also easy to cause experimental interruption or failure due to negligence. For example, in a long-term, multi-batch solid phase extraction experiment, the operator may forget to pay attention to the remaining solvent due to being busy with other operations, making the extraction process unable to proceed normally due to insufficient solvent. Summary of the invention

[0003] In view of the above defects or deficiencies in the prior art, the present application aims to provide a fully automatic solid phase extraction alarm device, comprising: A shell, wherein the shell has a first space, wherein the first space is provided with a plurality of solvent bottles distributed in sequence along a first direction, wherein the solvent bottles are filled with solvents, wherein a solvent conduit is inserted into the top of the solvent bottle, wherein one end of the solvent conduit extends and passes through the outside of the first space, and the other end extends to the bottom of the solvent bottle; The alarm mechanism includes a sensor component arranged outside each solvent bottle, each of the sensor components is used to monitor the liquid level changes of the solvent in the corresponding solvent bottle in real time, and trigger an alarm signal indicating low liquid level in the corresponding solvent bottle when the liquid level is lower than a set sensing area.

[0004] According to the technical solution provided in the embodiment of the present application, each of the sensor components is electrically connected to a corresponding display component, and the display component is arranged on the outer wall of the shell, and the display component is used to display the alarm signal with indicator lights of different colors or flashing frequencies.

[0005] According to the technical solution provided in the embodiment of the present application, the shell is made of light-proof material.

[0006] According to the technical solution provided in the embodiment of the present application, the sensing component is a U-shaped photoelectric liquid level sensor, the U-shaped photoelectric liquid level sensor is mounted outside the solvent bottle, and the projection area of ​​the U-shaped structure on the solvent bottle is the set sensing area.

[0007] According to the technical solution provided in the embodiment of the present application, a support adjustment component corresponding to each of the solvent bottles is also provided in the first space, and the support adjustment component is used to adjust the relative height between the sensor component and the solvent bottle along the second direction; the second direction is perpendicular to the first direction.

[0008] According to the technical solution provided in the embodiment of the present application, the solvent bottle is placed on the bottom plate of the shell, and the support and adjustment component is a sensor support frame arranged on one side of the solvent bottle, and the sensor support frame is used to support or adjust the height of the sensor component along the second direction.

[0009] According to the technical solution provided in the embodiment of the present application, the sensor component is arranged on a support platform of a fixed height, the support platform is arranged on the bottom plate of the shell, the support adjustment component is an adjustment support frame arranged at the bottom of the solvent bottle, the adjustment support frame is arranged on the bottom plate of the shell, and the adjustment support frame is used to support or adjust the height of the solvent bottle along the second direction.

[0010] According to the technical solution provided in the embodiment of the present application, the shell includes a bottom plate, the edge of the bottom plate extends along the second direction to form a plurality of interconnected side plates, one of the side plates is hinged to a top plate, the direction of the hinge axis is the first direction, and the top plate is provided with a plurality of through holes for passing through the solvent duct.

[0011] According to the technical solution provided in the embodiment of the present application, an anti-slip pad is provided at the bottom of the shell.

[0012] According to the technical solution provided in the embodiment of the present application, an observation window made of a dark transparent material is provided on the side panel.

[0013] In summary, the present application proposes a fully automatic solid phase extraction alarm device, comprising: a first space is provided in a shell, a plurality of solvent bottles are arranged in the first space and are distributed in sequence along a first direction, the solvent bottles are filled with solvent, a solvent conduit is inserted into the top of the solvent bottle, one end of the solvent conduit extends and passes through the outside of the first space, and the other end extends to the bottom of the solvent bottle; the alarm mechanism includes a sensor component arranged outside each solvent bottle, each sensor component is used to monitor the liquid level change of the solvent in the corresponding solvent bottle in real time, and trigger an alarm signal indicating the low liquid level in the corresponding solvent bottle when the liquid level is lower than the set sensing area.

[0014] Compared with the prior art, the beneficial effect of the present application is that the sensor components arranged outside each solvent bottle can monitor the change of solvent level in real time and accurately. Once the liquid level is lower than the set sensing area, an alarm signal is immediately triggered to inform the operator to add solvent in time, thus avoiding interruption of the experiment due to insufficient solvent, greatly improving the continuity and success rate of the experiment, and reducing the cost of human monitoring and the risk of errors. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 A schematic diagram of the structure of a fully automatic solid phase extraction alarm device provided in an embodiment of the present application; Figure 2A cross-sectional schematic diagram of a pneumatic turbine motor device provided in an embodiment of the present application.

[0016] The text annotations in the figure represent: 11. Shell; 12. Solvent conduit; 13. Display assembly; 21. Solvent bottle; 22. Sensor assembly; 23. Sensor support frame. DETAILED DESCRIPTION

[0017] The present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It is to be understood that the specific embodiments described herein are only used to explain the relevant invention, rather than to limit the invention. It is also necessary to explain that, for ease of description, only the parts related to the invention are shown in the accompanying drawings.

[0018] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application can be combined with each other. The present application will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0019] Example 1 As mentioned in the background technology, in response to the problems in the prior art, this application proposes a fully automatic solid phase extraction alarm device, please refer to Figure 1 As shown, including: A housing 11, wherein the housing 11 has a first space, wherein the first space is provided with a plurality of solvent bottles 21 sequentially distributed along a first direction, wherein the solvent bottles 21 are filled with solvent, wherein a solvent conduit 12 is inserted into the top of the solvent bottle 21, wherein one end of the solvent conduit 12 extends and passes through the outside of the first space, and the other end extends to the bottom of the solvent bottle 21; Furthermore, the housing 11 is made of light-proof material.

[0020] Specifically, the shell 11 has an internal space, namely the first space, which is shaped like a cuboid and provides accommodation and protection for the internal components. The material is a light-proof material that can block external light from entering. Several first spaces arranged in sequence in the shell 11 along a first direction (such as horizontally) are cylindrical in shape and are used to hold the solvent required for solid phase extraction. The bottle mouth is at the top, and the inside of the bottle body is hollow to store the solvent. The solvent conduit 12 is a slender tubular structure, one end of which is inserted from the top opening of the solvent bottle 21 to the bottom of the bottle to ensure that the solvent at the bottom of the bottle can be extracted, and the other end passes through the outer wall of the first space of the shell 11 and is connected to an external solid phase extraction device for transporting the solvent. The solvent bottle 21 is placed in the shell 11, and the solvent conduit 12 connects the solvent bottle 21 with the outside. The storage and transportation of the solvent is realized, and a stable solvent supply is provided for the solid phase extraction process. At the same time, the shell 11 is used to protect the solvent from light and prevent the solvent from deteriorating.

[0021] Specifically, the shell 11 is made of light-proof material, such as black plastic, metal-coated plate, etc. The material is tight and light-proof, creating a light-free environment for light-sensitive solvents, preventing the solvents from decomposing and deteriorating due to light, and ensuring the accuracy of the extraction experiment.

[0022] The alarm mechanism includes a sensor component 22 arranged outside each of the solvent bottles 21, and each of the sensor components 22 is used to monitor the liquid level changes of the solvent in the corresponding solvent bottle 21 in real time, and trigger an alarm signal indicating that the liquid level in the corresponding solvent bottle 21 is low when the liquid level is lower than a set sensing area.

[0023] In a preferred embodiment, each of the sensor components 22 is electrically connected to a corresponding display component 13, and the display component 13 is disposed on the outer wall of the shell 11. The display component 13 is used to display the alarm signal with indicator lights of different colors or flashing frequencies.

[0024] Specifically, the display component 13 is an indicator light, which is arranged on the outer wall of the housing 11, and is usually a circular or square light-emitting diode module, which is connected to the sensor component 22 through a circuit. The sensor component 22 is electrically connected to the corresponding display component 13, and the signal transmission is linked. The liquid level information can be visualized, and the operator can intuitively know the liquid level status of the solvent bottle 21 without opening the housing 11, thereby improving the convenience of operation and monitoring efficiency. After the sensor component 22 detects the low liquid level signal, it is transmitted to the display component 13, and the indicator light lights up with a specific color or flashing frequency.

[0025] In a preferred embodiment, the sensing component 22 is a U-shaped photoelectric liquid level sensor, which is mounted outside the solvent bottle 21 , and the projection area of ​​the U-shaped structure on the solvent bottle 21 is the set sensing area.

[0026] Specifically, the sensing component 22 is a U-shaped photoelectric liquid level sensor. The photoelectric liquid level sensor is independent of other characteristics of the medium, including temperature, pressure, density, and electrical parameters. Therefore, the liquid level detection is accurate, the repeatability is high, the response speed is fast, and the liquid level control is very precise. The U-shaped opening surrounds the solvent bottle 21, and the internal "U-shaped" area is an effective sensing area. A light source device (such as a light-emitting diode) and a light receiving device (such as a photoresistor) are respectively provided at both ends. When the liquid level is higher than the set sensing area, the light emitted by the light source device is refracted into the liquid, and the light receiving device receives a small amount or no light; when the liquid level is lower than the set sensing area, the light is directly reflected back to the light receiving device, which triggers an alarm signal.

[0027] In a preferred embodiment, a support adjustment component corresponding to each of the solvent bottles 21 is further provided in the first space, and the support adjustment component is used to adjust the relative height between the sensor component 22 and the solvent bottle 21 along a second direction; the second direction is perpendicular to the first direction.

[0028] In a preferred embodiment, the solvent bottle 21 is placed on the bottom plate of the shell 11, and the support and adjustment component is a sensor support frame 23 arranged on one side of the solvent bottle 21, and the sensor support frame 23 is used to support or adjust the height of the sensor component 22 along the second direction.

[0029] Specifically, Figure 2 As shown, the sensor support frame 23 is similar to a three-dimensional structure combining a column and a plate, and its bottom is firmly fixed to the bottom plate of the shell 11 by welding or screwing to ensure that there will be no displacement during the operation and movement of the device. On the side close to the solvent bottle 21, it extends a bearing plate with an adjustment structure, and this bearing plate is used as a support surface to carry the sensor component 22. The adjustment structure part, for example, is provided with a vertical slide rail, and a slider is matched and installed on the slide rail. The sensor component 22 is fixed on the slider. By pushing the slider up and down along the slide rail, the height of the sensor component 22 along the second direction (the height direction of the shell 11) can be conveniently adjusted; or a screw adjustment method is adopted, a vertical long hole is opened on the bearing plate, and the screw passes through the long hole to connect with the sensor component 22. Rotating the screw can drive the sensor component 22 to rise or fall.

[0030] When it is necessary to adapt to solvent bottles 21 of different height specifications, or when there are special requirements for the liquid level detection height according to different solid phase extraction experiments, the operator only needs to simply operate the adjustment structure of the sensor support frame 23 to quickly and accurately adjust the height position of the sensor component 22, ensuring that the "U-shaped" sensing area of ​​the photoelectric liquid level sensor and the liquid level in the solvent bottle 21 are in the best detection corresponding state, thereby reliably realizing real-time monitoring of solvent level changes and providing accurate and stable solvent residual early warning protection for the fully automatic solid phase extraction process.

[0031] At the same time, multiple photoelectric liquid level sensors can be connected in parallel and multiple sensing areas can be set to match different solid phase extraction requirements. No complex algorithms are required. It is only necessary to observe the triggering state of the photoelectric sensor to determine whether liquid addition and other operations are required.

[0032] In a preferred embodiment, the sensor component 22 is arranged on a support platform of a fixed height, and the support platform is arranged on the bottom plate of the shell 11. The support and adjustment component is an adjustment support frame arranged at the bottom of the solvent bottle 21, and the adjustment support frame is arranged on the bottom plate of the shell 11. The adjustment support frame is used to support or adjust the height of the solvent bottle 21 along the second direction.

[0033] Specifically, the support adjustment component is located at the bottom of the solvent bottle 21, and is a frame structure with an adjustment foot or gasket, which can change the height of the solvent bottle 21. The support frame is adjusted to support the solvent bottle 21, and the solvent bottle 21 and the sensor component 22 are adapted by changing the relative height, and the support table is fixed. The relative height adjustment between the sensor component 22 and the solvent bottle 21 is achieved to ensure the accuracy of liquid level detection and the structure is stable. By adjusting the support frame to change the height of the solvent bottle 21, the liquid level matches the set sensing area of ​​the sensor component 22.

[0034] In a preferred embodiment, the shell 11 includes a bottom plate, the edge of the bottom plate extends along the second direction to form a plurality of interconnected side plates, one of the side plates is hinged to a top plate, the direction of the hinge axis is the first direction, and the top plate is provided with a plurality of through holes for passing through the solvent conduit 12.

[0035] Specifically, the shell 11 is a rectangular structure consisting of a bottom plate, four side plates, and a top plate. The bottom plate is flat, and the side plates extend vertically upward along the edge of the bottom plate to form the side of the rectangular parallelepiped. One of the side plates is connected to the top plate by a hinge or other hinge structure, and the hinge axis is along the first direction. The top plate is also flat, and has a number of circular through holes on it, corresponding to the position of the solvent duct 12. The various components are connected into a whole by welding, hinges, etc., and the solvent duct 12 passes through the through hole of the top plate. The shell 11 facilitates the installation and maintenance of internal components such as the solvent bottle 21 and the sensor component 22, and the top plate can be opened and closed to improve the openness of the device. When the top plate is opened, the operator can operate the interior, and it remains closed and light-proof after closing.

[0036] In a preferred embodiment, an anti-slip pad is provided at the bottom of the housing 11 .

[0037] Specifically, an anti-skid pad is provided at the bottom, which is generally made of rubber, in sheet form, with raised textures or particles on the surface. The anti-skid pad is pasted or embedded on the lower surface of the bottom plate of the housing 11. The friction between the device and the placement plane is increased to prevent sliding during operation and vibration, thereby improving stability.

[0038] In a preferred embodiment, the side panel is provided with an observation window made of dark transparent material.

[0039] Specifically, an observation window is provided on the side panel of the housing 11. The observation window is made of a dark transparent material such as brown organic glass, is in the shape of a square or round sheet, is embedded in a hole reserved in the side panel, is sealed and embedded in the side panel, and is integrated with the side panel. Without destroying the light-proof performance of the housing 11, the operator can be allowed to check the appearance of the solvent bottle 21 to assist in monitoring. When the indicator light indicates that a solvent bottle 21 has a low liquid level, the top plate of the housing 11 can be left open first, and the solvent bottle 21 can be observed from the observation window first, and then the liquid adding operation can be performed after confirming that the liquid level is indeed low.

[0040] Specifically, the present application can improve the automation of solid phase extraction. It does not require manual observation of the remaining liquid in the solvent bottle 21. It only needs to judge the indication of the photoelectric liquid level sensor to determine whether liquid needs to be added. The risk of solid phase extraction experiments can be reduced. The device can effectively indicate the reagent inventory and avoid experimental failures due to insufficient reagents. Within the required width range of the photoelectric liquid level sensor detection slot, the diameter of the solvent bottle 21 can be replaced at will without adjusting the algorithm or hardware of the device.

[0041] Example 2 On the basis of Example 1, this embodiment proposes a control method for a fully automatic solid phase extraction alarm device. During the operation of the solid phase extraction experiment, each sensor component continuously monitors the liquid level change of the solvent in the corresponding solvent bottle at a set frequency (for example, once every 5 seconds), and transmits the liquid level data to the controller in real time. The controller synchronously collects other relevant operating parameters, such as the current stage information of the solid phase extraction process (such as the initial, middle and late stages of extraction, the solvent consumption rate is different in different stages), ambient temperature (because the temperature may slightly affect the solvent volatilization rate and thus affect the liquid level), experimental operation time, etc. Based on the collected multi-dimensional data, the intelligent algorithm built into the controller starts to run. The algorithm matches the corresponding liquid level change trend model in the preset empirical model library according to other relevant operating parameters (solvent bottle specifications, solid phase extraction process stage and ambient temperature and other factors). For example, for a large-capacity solvent bottle in the early stage of extraction and low temperature environment, the solvent consumption is relatively slow and the liquid level decline slope is small; while for a small-capacity solvent bottle in the late stage of extraction, high temperature environment and high-concentration sample processing, the solvent consumption is accelerated and the liquid level drops rapidly. According to the matched liquid level change trend model, the liquid level threshold corresponding to the solvent bottle is dynamically adjusted. If the rate of liquid level drop exceeds the model prediction range, for example, if the liquid level drops abnormally due to a solvent pipeline leak, the controller will not only immediately trigger an alarm signal, but also suspend the solid phase extraction process. At the same time, a specific flashing pattern (such as rapid double flashes) will be displayed on the display component (indicator light on the outer wall of the shell) to prompt the operator to check the pipeline.

[0042] Alarm and feedback stage: When the liquid level is lower than the adjusted threshold, the controller immediately sends instructions to the corresponding display component to make its indicator light display the low liquid level alarm signal with a preset color (such as red) and flashing frequency (such as always on). At the same time, it sends an alarm message to the host computer connected to the device (such as a laboratory management system computer), records the alarm time, solvent bottle number and other detailed data, to facilitate subsequent traceability analysis.

[0043] If the operator does not respond to the alarm and add solvent within a certain period of time (such as 5 minutes), the controller will trigger the buzzer again to sound a continuous alarm and send an emergency notification to more related devices (such as the laboratory broadcasting system and the person in charge’s mobile phone APP push notification) to ensure that the problem is handled in a timely manner and the experiment proceeds smoothly.

[0044] Through this adaptive liquid level threshold adjustment control method, the technical problem that the existing solid phase extraction alarm device cannot flexibly adjust the liquid level alarm threshold according to actual working conditions is solved, the intelligence and reliability of the device are improved, and the misjudgment or missed judgment of solvent shortage due to improper setting of fixed threshold is avoided, providing more accurate and efficient solvent residual monitoring guarantee for the fully automatic solid phase extraction process.

[0045] This article uses specific examples to illustrate the principles and implementation methods of this application. The description of the above embodiments is only used to help understand the method and its core ideas of this application. The above is only the preferred implementation method of this application. It should be pointed out that due to the limitations of textual expression and the objective existence of infinite specific structures, ordinary technicians in this technical field can make several improvements, modifications or changes without departing from the principles of the present invention, and can also combine the above technical features in an appropriate manner; these improvements, modifications, changes or combinations, or the direct application of the inventive concept and technical solution to other occasions without improvement, should be regarded as the scope of protection of this application.

Claims

1. A fully automatic solid phase extraction alarm device, characterized in that: include: A shell (11), wherein the shell (11) has a first space therein, wherein a plurality of solvent bottles (21) are arranged in sequence along a first direction, wherein the solvent bottles (21) are filled with solvent, wherein a solvent conduit (12) is inserted into the top of the solvent bottle (21), wherein one end of the solvent conduit (12) extends and penetrates outside the first space, and the other end extends to the bottom of the solvent bottle (21); An alarm mechanism, the alarm mechanism comprising a sensor component (22) arranged outside each of the solvent bottles (21), each of the sensor components (22) being used to monitor in real time the change in the liquid level of the solvent in the corresponding solvent bottle (21), and triggering an alarm signal indicating a low liquid level in the corresponding solvent bottle (21) when the liquid level is lower than a set sensing area.

2. The fully automatic solid phase extraction alarm device according to claim 1, characterized in that: Each of the sensor components (22) is electrically connected to a corresponding display component (13), wherein the display component (13) is arranged on the outer wall of the housing (11), and the display component (13) is used to display the alarm signal with indicator lights of different colors or flashing frequencies.

3. The fully automatic solid phase extraction alarm device according to claim 1, characterized in that: The housing (11) is made of light-proof material.

4. The fully automatic solid phase extraction alarm device according to claim 1, characterized in that: The sensing component (22) is a photoelectric liquid level sensor with a U-shaped structure. The photoelectric liquid level sensor with the U-shaped structure is sleeved outside the solvent bottle (21), and the projection area of ​​the U-shaped structure on the solvent bottle (21) is the set sensing area.

5. The fully automatic solid phase extraction alarm device according to claim 1, characterized in that: A support adjustment component corresponding to each of the solvent bottles (21) is also provided in the first space, and the support adjustment component is used to adjust the relative height between the sensor component (22) and the solvent bottle (21) along a second direction; the second direction is perpendicular to the first direction.

6. The fully automatic solid phase extraction alarm device according to claim 5, characterized in that: The solvent bottle (21) is placed on the bottom plate of the housing (11); the support and adjustment component is a sensor support frame (23) provided on one side of the solvent bottle (21); the sensor support frame (23) is used to support or adjust the height of the sensor component (22) along the second direction.

7. The fully automatic solid phase extraction alarm device according to claim 5, characterized in that: The sensor component (22) is arranged on a support platform of a fixed height, and the support platform is arranged on the bottom plate of the shell (11). The support adjustment component is an adjustment support frame arranged on the bottom of the solvent bottle (21), and the adjustment support frame is arranged on the bottom plate of the shell (11). The adjustment support frame is used to support or adjust the height of the solvent bottle (21) along the second direction.

8. The fully automatic solid phase extraction alarm device according to claim 1, characterized in that: The shell (11) comprises a bottom plate, the edge of the bottom plate extending along the second direction to form a plurality of mutually connected side plates, one of the side plates being hinged to a top plate, the direction of the hinge axis being the first direction, and the top plate being provided with a plurality of through holes for penetrating the solvent conduit (12).

9. The fully automatic solid phase extraction alarm device according to claim 1, characterized in that: An anti-slip pad is provided at the bottom of the housing (11).

10. The fully automatic solid phase extraction alarm device according to claim 8, characterized in that: The side panel is provided with an observation window made of dark transparent material.

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