Agilawood vagina cleaning care solution and preparation method thereof

Abstract

The invention provides an agilawood vagina cleaning care solution and a preparation method thereof. The care solution is prepared from the following raw materials: 20 to 35 parts of agilawood hydrolat, 15 to 20 parts of radix sophorae flavescentis, 15 to 20 parts of fructus cnidii, 15 to 20 parts of honeysuckle flower, 12 to 15 parts of a surfactant, 5 to 8 parts of a thickening agent, 0.01 to 0.1 part of a preservative, 0.5 to 1 part of a pH regulator and the balance of water. The preparation method comprises the following steps: S1, freeze-drying radix sophorae flavescentis, fructus cnidii and honeysuckle, crushing, adding water, performing high-pressure extraction, performing ultrasonic extraction, filtering, and performing vacuum concentration to obtain a mixed extract; s2, adding water into a reaction kettle, adding the surfactant and the thickening agent, uniformly mixing, adding the agilawood hydrolat, the mixed extract and the preservative, uniformly mixing again, and adjusting the pH value to obtain the agilawood vagina cleaning care solution. The care solution disclosed by the invention is reasonable in raw material matching, can play a synergistic effect, can effectively inhibit escherichia coli, staphylococcus aureus, candida albicans and the like, has a good cleaning effect on private parts and anus, is good in itching relieving effect, can also remove unpleasant odor, and is good in acting effect.

Description

Technical Field

[0001] The invention relates to the technical field of care solutions, and in particular to an agarwood vaginal cleaning care solution and a preparation method thereof. Background Art

[0002] The genitals or anus of men and women are easily infected by pathogenic bacteria such as Escherichia coli, Staphylococcus aureus and Candida albicans due to local uncleanliness, changes in environmental conditions or decreased resistance, causing itching and inflammation. Itching attacks one after another can cause emotional ups and downs. When it is unbearable, it is often necessary to scratch the skin to relieve itching. Frequent scratching of the skin can easily lead to skin damage, erosion, scab, hypertrophy and lichenification, which is not conducive to the health of the skin and body and mind. At present, although some genital care liquids have appeared on the market, the effects are not ideal due to unreasonable raw material composition or poor preparation process, and they are more irritating to the genitals or anus. Frequent use will affect the microenvironment of the genitals or anus, causing the itching to become more and more serious.

[0003] Agarwood is the resin-containing wood of the Thymelaeaceae plant Aquilaria sinensis (Lour.) Gilg. It has multiple biological activities such as antibacterial, anti-inflammatory, and anti-tumor. Combining it with other raw materials to make a care solution can provide a reference for the further development and utilization of agarwood. Summary of the invention

[0004] In view of this, the present invention proposes an agarwood vaginal cleaning care liquid and a preparation method thereof. The care liquid of the present invention has reasonable raw material matching, can play a synergistic role, can effectively inhibit Escherichia coli, Staphylococcus aureus and Candida albicans, etc., has a good cleaning effect on the vagina and anus, has a good antipruritic effect, and can also remove bad odors, with a good effect.

[0005] The technical solution of the present invention is achieved in this way:

[0006] A method for preparing an agarwood vaginal cleaning care solution comprises the following steps:

[0007] S1. Freeze-drying and crushing Sophora flavescens, Cnidium monnieri and Honeysuckle to obtain a mixture, adding water to the mixture and soaking it at a temperature of 30-45° C. for 3-4 hours to obtain a mixed liquid, first increasing the pressure of the mixed liquid to 100-200 MPa at a rate of 20-30 MPa / min and maintaining the pressure for 5-6 minutes, then reducing the pressure to 50-100 MPa at a rate of 40-50 MPa / min and maintaining the pressure for 3-4 minutes, then increasing the pressure to 300-400 MPa at a rate of 80-100 MPa and maintaining the pressure for 6-8 minutes, finally performing high-pressure extraction at a rate of 40-50 MPa / min, then performing ultrasonic extraction, filtering to obtain a filtrate, and concentrating the filtrate under reduced pressure to obtain a mixed extract;

[0008] S2. Add water to the reaction kettle, then add surfactant and thickener while stirring, stir and mix, then add agarwood hydrosol, mixed extract and preservative and stir and mix again, use pH adjuster to adjust pH value to 5-6, and obtain agarwood vaginal care solution.

[0009] Furthermore, the freeze-drying is carried out at a temperature of -20 to -30°C and a vacuum degree of 30 to 40 Pa for 60 to 90 minutes.

[0010] Furthermore, the material-liquid ratio of the mixture to water is 1:12-18 in mg / mL.

[0011] Furthermore, the ultrasonic extraction is performed at an ultrasonic power of 500-600W and a temperature of 30-50°C for 10-12 minutes.

[0012] The agarwood vagina cleaning care liquid is prepared by the preparation method of the invention.

[0013] Furthermore, the agarwood vaginal cleaning care liquid comprises the following raw materials in parts by weight: 20-35 parts of agarwood pure water, 15-20 parts of Sophora flavescens, 15-20 parts of Cnidium monnieri, 15-20 parts of honeysuckle, 12-15 parts of surfactant, 5-8 parts of thickener, 0.01-0.1 parts of preservative, 0.5-1 parts of pH adjuster, and the remainder of water.

[0014] Furthermore, the surfactant is selected from one or more of cocamide, cocamidopropyl betaine, and sodium lauroyl glutamate.

[0015] Furthermore, the thickener is selected from one or more of glycerol, polyethylene glycol, and hydroxyethyl cellulose.

[0016] Furthermore, the preservative is selected from one or more of sodium benzoate, methylparaben, and propylparaben.

[0017] Furthermore, the pH regulator is sodium hydroxide or triethanolamine.

[0018] Furthermore, the preparation process of the agarwood hydrosol of the present invention is: the agarwood is crushed into 60 mesh and then added into a distillation extraction tank, purified water is added according to a solid-liquid ratio of 1:6 mg / mL, steam is used to heat to boiling, and then refluxed for 4 hours, the distillate after distillation is collected, oil-water separation is performed, and the aqueous solution is collected to obtain the agarwood hydrosol.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] Through a reasonable preparation process, the present invention can make the various active ingredients in the agarwood hydrosol, sophora flavescens, cnidium monnieri, honeysuckle and the like in the care solution play a synergistic role, improve the inhibitory effect on pathogenic bacteria such as Escherichia coli, Staphylococcus aureus and Candida albicans, maintain the cleanliness of the genitals and anus, effectively relieve itching, and also remove bad odors.

[0021] In the preparation process of the present invention, firstly, lyophilize Sophora flavescens, Cnidium monnieri and honeysuckle and combine with suitable high pressure and ultrasonic extraction process, so as to effectively extract the active substances in Sophora flavescens, Cnidium monnieri and honeysuckle, and extract at a lower temperature at the same time, so as to avoid the destruction of the active ingredients and improve the antibacterial effect. In particular, the integrity of the plant cell wall can be fully destroyed under different high pressure conditions, so as to improve the release of the active ingredients, and the extraction efficiency of the active ingredients can be improved by ultrasonic extraction after the high pressure. DETAILED DESCRIPTION

[0022] In order to better understand the technical content of the present invention, specific embodiments are provided below to further illustrate the present invention.

[0023] Unless otherwise specified, the experimental methods used in the embodiments of the present invention are all conventional methods.

[0024] Unless otherwise specified, the materials, reagents, etc. used in the embodiments of the present invention can be obtained from commercial sources.

[0025] Example 1

[0026] The agarwood vaginal cleaning care solution of this embodiment includes the following raw materials in parts by weight: 26 parts of agarwood hydrosol, 18 parts of sophora flavescens, 20 parts of cnidium monnieri, 17 parts of honeysuckle, 13 parts of surfactant, 6 parts of thickener, 0.05 parts of preservative, 0.5 parts of pH regulator, and 120 parts of water;

[0027] The surfactant is composed of cocamidopropyl betaine and sodium lauroyl glutamate in a mass ratio of 2:1; the thickener is composed of glycerol and polyethylene glycol in a mass ratio of 3:2; the preservative is sodium benzoate; and the pH adjuster is sodium hydroxide or triethanolamine;

[0028] The preparation method of the agarwood vaginal cleaning care liquid implemented in this embodiment comprises the following steps:

[0029] S1. Freeze-dry Sophora flavescens, Cnidium monnieri and Lonicera japonica at -30°C and vacuum at 40Pa for 80min, then grind and mix to obtain a mixture; according to the material-liquid ratio of the mixture to water of 1:15 in mg / mL, add water to the mixture and soak it at 40°C for 4h to obtain a mixed liquid, first increase the pressure of the mixed liquid to 200MPa at a rate of 25MPa / min and maintain the pressure for 6min, then reduce the pressure to 80MPa at a rate of 50MPa / min and maintain the pressure for 3min, then increase the pressure to 350MPa at a rate of 80MPa and maintain the pressure for 6min, finally reduce the pressure to normal pressure at a rate of 40MPa / min, then perform ultrasonic extraction at an ultrasonic power of 600W and a temperature of 40°C for 10min, filter to obtain a filtrate, and concentrate the filtrate under reduced pressure to obtain a mixed extract; the volume of the mixed extract is 50% of the volume of the filtrate;

[0030] S2. Add water to the reactor, then add surfactant and thickener while stirring, then add agarwood hydrosol, mixed extract and preservative and stir again, and use pH adjuster to adjust pH value to 5.5 to obtain agarwood vaginal care solution.

[0031] Example 2

[0032] The agarwood vaginal cleaning care solution of this embodiment includes the following raw materials in parts by weight: 25 parts of agarwood hydrosol, 15 parts of sophora flavescens, 18 parts of cnidium monnieri, 20 parts of honeysuckle, 15 parts of surfactant, 5 parts of thickener, 0.08 parts of preservative, 0.5 parts of pH regulator, and 130 parts of water;

[0033] The surfactant is cocamide; the thickener is hydroxyethyl cellulose; the preservative is methyl paraben; the pH adjuster is sodium hydroxide or triethanolamine;

[0034] The preparation method of the agarwood vaginal cleaning care liquid implemented in this embodiment comprises the following steps:

[0035] S1. Freeze-dry Sophora flavescens, Cnidium monnieri and Lonicera japonica at -25°C and vacuum at 30Pa for 90min, then grind and mix to obtain a mixture; according to the material-liquid ratio of the mixture to water (mg / mL) of 1:12, add water to the mixture and soak it at 45°C for 3h to obtain a mixed liquid, first increase the pressure of the mixed liquid to 150MPa at a rate of 30MPa / min and maintain the pressure for 6min, then reduce the pressure to 100MPa at a rate of 40MPa / min and maintain the pressure for 4min, then increase the pressure to 300MPa at a rate of 100MPa and maintain the pressure for 7min, finally reduce the pressure to normal pressure at a rate of 50MPa / min, then perform ultrasonic extraction at an ultrasonic power of 500W and a temperature of 50°C for 12min, filter to obtain a filtrate, and concentrate the filtrate under reduced pressure to obtain a mixed extract; the volume of the mixed extract is 50% of the volume of the filtrate;

[0036] S2. Add water to the reactor, then add surfactant and thickener while stirring, then add agarwood hydrosol, mixed extract and preservative and stir again, and use pH adjuster to adjust pH value to 6 to obtain agarwood vaginal care solution.

[0037] Example 3

[0038] The agarwood vaginal cleaning care solution of this embodiment includes the following raw materials in parts by weight: 20 parts of agarwood hydrosol, 20 parts of sophora flavescens, 15 parts of cnidium monnieri, 18 parts of honeysuckle, 14 parts of surfactant, 7 parts of thickener, 0.06 parts of preservative, 0.6 parts of pH regulator, and 120 parts of water;

[0039] The surfactant is composed of cocamide and sodium lauroyl glutamate in a mass ratio of 3:1; the thickener is polyethylene glycol; the preservative is propylparaben; and the pH adjuster is sodium hydroxide or triethanolamine;

[0040] The preparation method of the agarwood vaginal cleaning care liquid implemented in this embodiment comprises the following steps:

[0041] S1. Freeze-dry Sophora flavescens, Cnidium monnieri and Flos Lonicerae at -20°C and vacuum degree of 35Pa for 60min, then grind and mix to obtain a mixture; according to the material-liquid ratio of the mixture to water of 1:18 in mg / mL, add water to the mixture and soak it at 30°C for 3.5h to obtain a mixed liquid, first increase the pressure of the mixed liquid to 100MPa at a rate of 20MPa / min and maintain the pressure for 5min, then reduce the pressure to 50MPa at a rate of 45MPa / min and maintain the pressure for 3min, then increase the pressure to 350MPa at a rate of 80MPa and maintain the pressure for 8min, finally reduce the pressure to normal pressure at a rate of 40MPa / min, then perform ultrasonic extraction at an ultrasonic power of 500W and a temperature of 45°C for 11min, filter to obtain a filtrate, and concentrate the filtrate under reduced pressure to obtain a mixed extract; the volume of the mixed extract is 50% of the volume of the filtrate;

[0042] S2. Add water to the reactor, then add surfactant and thickener while stirring to mix, then add agarwood hydrosol, mixed extract and preservative and stir again to mix, use pH adjuster to adjust pH value to 5 to obtain agarwood vaginal care solution.

[0043] Comparative Example 1

[0044] In this comparative example, the process conditions of high pressure extraction were changed, and the rest were the same as those in Example 1.

[0045] The preparation method of the agarwood vaginal cleaning care liquid of this comparative example comprises the following steps:

[0046] S1. Freeze-dry Sophora flavescens, Cnidium monnieri and Lonicera japonica at -30°C and vacuum degree of 40Pa for 80min, then grind and mix to obtain a mixture; according to the material-liquid ratio of the mixture to water of 1:15 in mg / mL, add water to the mixture and soak it at 40°C for 4h to obtain a mixed liquid, increase the pressure of the mixed liquid from 60MPa / min to 500MPa and maintain the pressure for 15min, then reduce the pressure to normal pressure at a rate of 100MPa / min, and then perform ultrasonic extraction at an ultrasonic power of 600W and a temperature of 40°C for 10min, filter to obtain a filtrate, and concentrate the filtrate under reduced pressure to obtain a mixed extract; the volume of the mixed extract is 50% of the volume of the filtrate;

[0047] S2. Add water to the reactor, then add surfactant and thickener while stirring, then add agarwood hydrosol, mixed extract and preservative and stir again, and use pH adjuster to adjust pH value to 5.5 to obtain agarwood vaginal care solution.

[0048] Comparative Example 2

[0049] In this comparative example, freeze drying is replaced by drying, and the rest is the same as in Example 1.

[0050] The preparation method of the agarwood vaginal cleaning care liquid of this comparative example comprises the following steps:

[0051] S1. Dry Sophora flavescens, Cnidium monnieri and Lonicera japonica at 70°C to constant weight, then crush and mix to obtain a mixture; according to the material-liquid ratio of the mixture to water of 1:15 in mg / mL, add water to the mixture and soak it at 40°C for 4 hours to obtain a mixed liquid, first increase the pressure of the mixed liquid to 200MPa at a rate of 25MPa / min and maintain the pressure for 6min, then reduce the pressure to 80MPa at a rate of 50MPa / min and maintain the pressure for 3min, then increase the pressure to 350MPa at a rate of 80MPa and maintain the pressure for 6min, finally reduce the pressure to normal pressure at a rate of 40MPa / min, and then perform ultrasonic extraction at an ultrasonic power of 600W and a temperature of 40°C for 10min, filter to obtain a filtrate, and reduce the pressure and concentrate the filtrate to obtain a mixed extract; the volume of the mixed extract is 50% of the volume of the filtrate;

[0052] S2. Add water to the reactor, then add surfactant and thickener while stirring, then add agarwood hydrosol, mixed extract and preservative and stir again, and use pH adjuster to adjust pH value to 5.5 to obtain agarwood vaginal care solution.

[0053] Comparative Example 3

[0054] This comparative example lacks the step of ultrasonic extraction, and the rest is the same as Example 1.

[0055] The preparation method of the agarwood vaginal cleaning care liquid of this comparative example comprises the following steps:

[0056] S1. Freeze-dry Sophora flavescens, Cnidium monnieri and Lonicera japonica at -30°C and vacuum at 40Pa for 80min, then grind and mix to obtain a mixture; according to the ratio of the mixture to water in mg / mL of 1:15, add water to the mixture and soak it at 40°C for 4h to obtain a mixed liquid, first increase the pressure of the mixed liquid to 200MPa at a rate of 25MPa / min and maintain the pressure for 6min, then reduce the pressure to 80MPa at a rate of 50MPa / min and maintain the pressure for 3min, then increase the pressure to 350MPa at a rate of 80MPa and maintain the pressure for 6min, finally reduce the pressure to normal pressure at a rate of 40MPa / min, filter to obtain a filtrate, and concentrate the filtrate under reduced pressure to obtain a mixed extract; the volume of the mixed extract is 50% of the volume of the filtrate;

[0057] S2. Add water to the reactor, then add surfactant and thickener while stirring, then add agarwood hydrosol, mixed extract and preservative and stir again, and use pH adjuster to adjust pH value to 5.5 to obtain agarwood vaginal care solution.

[0058] Comparative Example 4

[0059] This comparative example changes the raw material composition and ratio of the agarwood vaginal cleaning care liquid, and the rest is the same as Example 1.

[0060] The agarwood vaginal cleaning care liquid of this comparative example comprises the following raw materials in parts by weight: 8 parts of agarwood pure water, 10 parts of Sophora flavescens, 10 parts of Cnidium monnieri, 53 parts of honeysuckle, 13 parts of surfactant, 10 parts of thickener, 0.05 parts of preservative, 0.5 parts of pH adjuster and 120 parts of water.

[0061] The agarwood vaginal cleaning care solution prepared in the above Examples 1-3 and Comparative Examples 1-4 was tested for antibacterial performance, and the test bacteria were Escherichia coli (ATCC 8739), Staphylococcus aureus (ATCC 6538), and Candida albicans (ATCC10231).

[0062] First, the test strains were inoculated and activated (cultured at 37°C for 24 h), and then the activated strains were selected and diluted with sterile saline to a concentration of 10 6 CFU / mL of bacterial suspension; under sterile conditions, use a pipette to take 0.1mL of the bacterial suspension of each bacterial species onto a solidified flat plate containing beef extract peptone agar medium; then use sterile tweezers to place the sterilized small round filter paper with a diameter of 6mm into the corresponding embodiment and comparative example of the agarwood cleaning yin care solution, soak for 30s, take it out and stick it on the flat plate culture dish, and then place it in an incubator and culture it at 37°C for 24h as the experimental group and measure the diameter of the antibacterial circle. For each bacterial species experiment in each embodiment and comparative example, 3 flat plate samples were made in parallel, and the antibacterial circle diameter measurement value was taken as the average of 5 measurements, and the measurement result was taken as the average value. The antibacterial diameter of the filter paper method is ≥10mm for effective, and the antibacterial diameter is ≤10mm for invalid.

[0063] Table 1 Antibacterial effect of agarwood vaginal cleaning care solution

[0064]

[0065]

[0066] The above results show that the preparation methods of Examples 1-3 of the present invention can improve the antibacterial effect of the agarwood vaginal care solution, especially have a good inhibitory effect on pathogenic bacteria such as Escherichia coli, Staphylococcus aureus and Candida albicans, and can prevent these pathogenic bacteria from infecting the vagina or anus and causing inflammation. Compared with Example 1, Comparative Examples 1-4 changed the high-pressure extraction process conditions, freeze-drying process, ultrasonic extraction process and raw material composition ratio of the agarwood vaginal care solution, resulting in changes in the active ingredients, and weakening the synergistic antibacterial effect.

[0067] The agarwood vagina cleaning care solution of the above-mentioned embodiments 1-3 and comparative examples 1-4 of the present invention was used in the experiment of cleaning the vulva itching of patients. The patients were 140 women aged 18 to 45 years old, who had not used antifungal drugs in the past 3 months and felt vulvar itching. Gynecological examination showed that the vulvar skin and vaginal mucosa were red and congested, and the secretions were large, yellow and smelly. The 140 female patients were randomly divided into 7 groups, 20 in each group, corresponding to the groups of embodiments 1-3 and comparative examples 1-4 respectively. After each group of patients used clean water to clean the vulva every night, they used the agarwood vagina cleaning care of the above-mentioned embodiments and comparative examples to dilute 5 times with water and heat to 30°C, and then cleaned the vulva, once a day for 5 minutes each time, for 14 consecutive days. After 14 days, the use effect of each patient was counted and recorded.

[0068] Cured: Itching symptoms disappear, vulvar skin returns to normal, vaginal mucosa is no longer congested, secretions are reduced, there is no odor, and the color is normal.

[0069] Improvement: Itching symptoms are alleviated, vaginal mucosa is no longer congested, secretions are reduced, and the color is basically normal.

[0070] Ineffective: No change in pruritus symptoms, no change in vulvar skin and vaginal mucosa during vaginal examination.

[0071] Total effective rate (%) = (number of cured cases + number of improved cases) / total number of cases in each group

[0072] The results are shown in Table 2 below.

[0073] Table 2 Effect of using agarwood vaginal cleaning care solution

[0074]

[0075]

[0076] The above results show that, by using a reasonable preparation method and a suitable raw material ratio of agarwood hydrosol to Sophora flavescens, Cnidium monnieri, and honeysuckle, the agarwood vaginal cleaning care solution can achieve a good antipruritic effect, improve the odor of the vagina, keep the vagina clean, and have a good effect. Comparative Examples 1-4 reduce the active ingredients and reduce the synergistic effect of each active ingredient due to the change in the preparation process or raw material ratio, and the use effect is reduced.

[0077] In addition, the agarwood vaginal cleaning care liquid according to the embodiment of the present invention is used for cleaning the male vulva and the male and female anus to achieve good antibacterial and antipruritic effects as well as the removal of bad odors.

[0078] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A method for preparing an agarwood vaginal cleaning care solution, characterized in that: The following steps are involved: S1. Freeze-drying and crushing Sophora flavescens, Cnidium monnieri and Honeysuckle to obtain a mixture, adding water to the mixture and soaking it at a temperature of 30-45° C. for 3-4 hours to obtain a mixed liquid, first increasing the pressure of the mixed liquid to 100-200 MPa at a rate of 20-30 MPa / min and maintaining the pressure for 5-6 minutes, then reducing the pressure to 50-100 MPa at a rate of 40-50 MPa / min and maintaining the pressure for 3-4 minutes, then increasing the pressure to 300-400 MPa at a rate of 80-100 MPa and maintaining the pressure for 6-8 minutes, finally performing high-pressure extraction at a rate of 40-50 MPa / min, then performing ultrasonic extraction, filtering to obtain a filtrate, and concentrating the filtrate under reduced pressure to obtain a mixed extract; S2. Add water to the reaction kettle, then add surfactant and thickener while stirring, stir and mix, then add agarwood hydrosol, mixed extract and preservative and stir and mix again, use pH adjuster to adjust pH value to 5-6, and obtain agarwood vaginal care solution.

2. The method for preparing the agarwood vaginal cleaning care solution according to claim 1, characterized in that: The freeze drying is carried out for 60 to 90 minutes under the conditions of -20 to -30°C and 30 to 40 Pa vacuum.

3. The method for preparing the agarwood vaginal cleaning care solution according to claim 1, characterized in that: The material-liquid ratio of the mixture to water is 1:12-18 in mg / mL.

4. The method for preparing the agarwood vaginal cleaning care solution according to claim 1, characterized in that: The ultrasonic extraction is performed for 10 to 12 minutes under the conditions of ultrasonic power of 500 to 600 W and temperature of 30 to 50° C.

5. Agarwood vaginal cleaning care liquid prepared by the preparation method described in any one of claims 1 to 4.

6. The agarwood vaginal cleaning care liquid according to claim 5, characterized in that: The invention comprises the following raw materials in parts by weight: 20-35 parts of agarwood hydrosol, 15-20 parts of sophora flavescens, 15-20 parts of cnidium monnieri, 15-20 parts of honeysuckle, 12-15 parts of surfactant, 5-8 parts of thickener, 0.01-0.1 parts of preservative, 0.5-1 parts of pH adjuster and the balance of water.

7. The agarwood vaginal cleaning care liquid according to claim 6, characterized in that: The surfactant is selected from one or more of cocamide, cocamidopropyl betaine, and sodium lauroyl glutamate.

8. The agarwood vaginal cleaning care liquid according to claim 6, characterized in that: The thickener is selected from one or more of glycerol, polyethylene glycol, and hydroxyethyl cellulose.

9. The agarwood vaginal cleaning care liquid according to claim 6, characterized in that: The preservative is selected from one or more of sodium benzoate, methylparaben and propylparaben.

10. The agarwood vaginal cleaning care liquid according to claim 6, characterized in that: The pH regulator is sodium hydroxide or triethanolamine.

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