Traditional Chinese medicine ointment for treating diabetic ulcer and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine ointment for treating diabetic ulcer and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines and ointment preparation. According to the traditional Chinese medicine ointment, effective components in the traditional Chinese medicine raw materials are extracted and blended into an ointment form through a specific preparation process, and the traditional Chinese medicine ointment is prepared by carefully selecting the traditional Chinese medicine raw materials with the effects of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials, removing slough and promoting tissue regeneration and the like according to the pathological characteristics of diabetic ulcer. The traditional Chinese medicine composition has the effects of resisting inflammation, resisting bacteria and promoting blood circulation and cell regeneration, can directly treat an ulcer surface, and effectively promotes ulcer healing.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine and ointment preparation, in particular to a traditional Chinese medicine ointment for treating diabetic ulcer and a preparation method thereof. Background Art

[0002] Diabetic ulcer is one of the common complications of diabetic patients, and its treatment process is complicated and long. Traditional Chinese medicine has unique advantages in the treatment of diabetic ulcer, but the existing Chinese medicine preparations still need to be improved in terms of preparation process, efficacy stability and patient acceptance. Therefore, it is of great significance to develop a Chinese medicine ointment for the treatment of diabetic ulcer with simple preparation process, stable efficacy and easy patient acceptance. Summary of the invention

[0003] The object of the present invention is to provide a Chinese medicinal ointment for treating diabetic ulcer and a preparation method thereof, so as to solve the problems raised in the above-mentioned background technology.

[0004] To achieve the above object, the present invention provides the following technical solution: a Chinese medicine ointment for treating diabetic ulcer and a preparation method thereof, comprising the following steps:

[0005] S1. Raw material preparation: Select raw materials such as Prunus mume seeds, Atractylodes lancea, rice sprouts, Magnolia officinalis, etc. that meet the medicinal standards, and wash and dry them;

[0006] S2, pretreatment: crushing or slicing the raw material obtained in step S1 to improve the subsequent extraction efficiency;

[0007] S3, soaking extraction: crush the raw material pretreated in step S2, sieve it and put it into an extraction container, add an appropriate amount of solvent, and soak it in water for 2-4 days;

[0008] S4, decoction and separation of juice: put the raw materials soaked in step S3 together with the solvent into a decoction container, boil over high heat until boiling, then change to low heat, boil until the volume of the decoction is 150-350mL, cool, and separate the residue and juice in the decoction by filtering or centrifugation;

[0009] S5, preparation: the juice obtained in step S4 is added to the auxiliary materials, and the container should be continuously stirred or shaken during the preparation process to ensure the uniformity and stability of the ointment, sterilized by high-pressure steam, cooled, and after the preparation is completed, necessary quality inspection and testing can be carried out to ensure that the ointment meets the relevant standards and requirements;

[0010] S6. Packaging: Fill the prepared ointment. The filling container should be selected to meet the pharmaceutical standards and be cleaned and disinfected. After filling, the ointment is sealed to ensure its sealing and hygienic quality. Finally, the ointment is labeled and necessary product information and instructions are provided;

[0011] As a further preferred embodiment of the present technical solution: the ratio of the raw materials in S1 is 10-30 parts of Prunus mume seeds, 5-20 parts of Atractylodes lancea, 5-15 parts of rice sprouts, and 5-15 parts of Magnolia officinalis.

[0012] As a further preferred embodiment of the present technical solution: the crushing or slicing process in step S2 is performed by mechanical crushing or manual slicing to ensure that the particle size of the raw material is uniform and easy to extract;

[0013] As a further preferred embodiment of the present technical solution: the soaking extraction in step S3 adopts water extraction or alcohol extraction, and the selection and dosage of the solvent shall be determined according to the properties of the raw materials and the extraction efficiency;

[0014] As a further preferred embodiment of the present technical solution: the decoction time in step S4 should be adjusted according to the properties of the raw materials and the extraction efficiency, generally 1 to 3 hours, and the decoction process in step S4 needs to control the heat and time to avoid the effective ingredients in the medicinal materials from being destroyed or lost;

[0015] As a further preferred embodiment of the present technical solution: the auxiliary materials in step S4 include a matrix material, a moisturizing agent, and a preservative, wherein the matrix material may be vaseline, beeswax, etc., the moisturizing agent may be glycerin, hyaluronic acid, etc., and the preservative may be sodium benzoate, potassium sorbate, etc.;

[0016] As a further preferred embodiment of the present technical solution: the selection of auxiliary materials in step S5 needs to take into account the stability, ease of use and patient acceptance of the ointment;

[0017] As a further preferred embodiment of the present technical solution: the packaging process in step S6 needs to follow the principle of aseptic operation to ensure the sanitary quality of the ointment during the packaging process.

[0018] Compared with the prior art, the beneficial effects of the present invention are as follows: the present invention extracts the effective ingredients in the Chinese medicinal raw materials and formulates them into the form of ointment through a specific preparation process; the Chinese medicinal ointment is prepared according to the pathological characteristics of diabetic ulcers, using selected Chinese medicinal raw materials with the effects of promoting blood circulation and removing blood stasis, clearing away heat and detoxifying, removing dead tissue and promoting tissue regeneration; the Chinese medicinal ointment penetrates into the ulcer surface through the skin, exerts anti-inflammatory, antibacterial, blood circulation promoting and cell regeneration effects, can directly treat the ulcer surface, and effectively promote ulcer healing. DETAILED DESCRIPTION

[0019] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0020] Example

[0021] The present invention provides a technical solution: a Chinese medicine ointment for treating diabetic ulcer and a preparation method thereof, comprising the following steps:

[0022] S1. Raw material preparation: Select raw materials such as Prunus mume seeds, Atractylodes lancea, rice sprouts, Magnolia officinalis, etc. that meet the medicinal standards, and wash and dry them;

[0023] S2, pretreatment: crushing or slicing the raw material obtained in step S1 to improve the subsequent extraction efficiency;

[0024] S3, soaking extraction: crush the raw material pretreated in step S2, sieve it and put it into an extraction container, add an appropriate amount of solvent, and soak it in water for 2-4 days;

[0025] S4, decoction and separation of juice: put the raw materials soaked in step S3 together with the solvent into a decoction container, boil over high heat until boiling, then change to low heat, boil until the volume of the decoction is 150-350mL, cool, and separate the residue and juice in the decoction by filtering or centrifugation;

[0026] S5, preparation: the juice obtained in step S4 is added to the auxiliary materials, and the container should be continuously stirred or shaken during the preparation process to ensure the uniformity and stability of the ointment, sterilized by high-pressure steam, cooled, and after the preparation is completed, necessary quality inspection and testing can be carried out to ensure that the ointment meets the relevant standards and requirements;

[0027] S6. Packaging: The prepared ointment is filled in containers that meet pharmaceutical standards and are cleaned and sterilized. After filling, the ointment is sealed to ensure its sealing and hygienic quality. Finally, the ointment is labeled and necessary product information and instructions are provided.

[0028] In this embodiment, specifically, the ratio of the raw materials in S1 is 10-30 parts of Prunus mume seeds, 5-20 parts of Atractylodes lancea, 5-15 parts of rice sprouts, and 5-15 parts of Magnolia officinalis.

[0029] In this embodiment, specifically: the crushing or slicing process in step S2 adopts mechanical crushing or manual slicing to ensure that the particle size of the raw material is uniform and easy to extract.

[0030] In this embodiment, specifically: the soaking extraction in step S3 adopts water extraction or alcohol extraction, and the selection and dosage of the solvent need to be determined according to the properties of the raw materials and the extraction efficiency.

[0031] In this embodiment, specifically: the decoction time in step S4 should be adjusted according to the properties of the raw materials and the extraction efficiency, generally 1 to 3 hours. The decoction process in step S4 needs to control the heat and time to avoid the effective ingredients in the medicinal materials from being destroyed or lost.

[0032] In this embodiment, specifically: the auxiliary materials in step S4 include a matrix material, a moisturizing agent, and a preservative. The matrix material can be selected from vaseline, beeswax, etc., the moisturizing agent can be selected from glycerin, hyaluronic acid, etc., and the preservative can be selected from sodium benzoate, potassium sorbate, etc.

[0033] In this embodiment, specifically: the selection of excipients in step S5 needs to take into account the stability, ease of use and patient acceptance of the ointment.

[0034] In this embodiment, specifically: the packaging process in step S6 must follow the principle of aseptic operation to ensure the sanitary quality of the ointment during the packaging process.

[0035] Working principle or structural principle: firstly, 20 parts of Prunus mume seeds, 10 parts of Atractylodes lancea, 10 parts of rice sprouts and 10 parts of Magnolia officinalis are used, and the raw materials are pretreated, soaked, extracted, decocted to separate the juice, formulated and packaged through steps S1 to S6 to ensure the content and stability of the active ingredients in the ointment. The active ingredients in the ointment penetrate into the ulcer surface through the skin, play anti-inflammatory, antibacterial, blood circulation and cell regeneration effects, thereby accelerating the healing process. Alternatively, 15 parts of Prunus mume seeds, 15 parts of Atractylodes lancea, 8 parts of rice sprouts and 12 parts of Magnolia officinalis are used, and the raw materials are pretreated, soaked, extracted, decocted to separate the juice, formulated and packaged through steps S1 to S6 to ensure the content and stability of the active ingredients in the ointment. The ointment focuses more on regulating moisture in the body, improving microcirculation and promoting cell regeneration, thereby accelerating the healing process of the ulcer.

[0036] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicinal ointment for treating diabetic ulcer and a preparation method thereof, characterized in that: The following steps are involved: S1. Raw material preparation: Select raw materials such as Prunus mume seeds, Atractylodes lancea, rice sprouts, Magnolia officinalis, etc. that meet the medicinal standards, and wash and dry them; S2, pretreatment: crushing or slicing the raw material obtained in step S1 to improve the subsequent extraction efficiency; S3, soaking extraction: crush the raw material pretreated in step S2, sieve it and put it into an extraction container, add an appropriate amount of solvent, and soak it in water for 2-4 days; S4, decoction and separation of juice: put the raw materials soaked in step S3 together with the solvent into a decoction container, boil over high heat until boiling, then change to low heat, boil until the volume of the decoction is 150-350mL, cool, and separate the residue and juice in the decoction by filtering or centrifugation; S5, preparation: the juice obtained in step S4 is added to the auxiliary materials, and the container should be continuously stirred or shaken during the preparation process to ensure the uniformity and stability of the ointment, sterilized by high-pressure steam, cooled, and after the preparation is completed, necessary quality inspection and testing can be carried out to ensure that the ointment meets the relevant standards and requirements; S6. Packaging: The prepared ointment is filled in containers that meet pharmaceutical standards and are cleaned and sterilized. After filling, the ointment is sealed to ensure its sealing and hygienic quality. Finally, the ointment is labeled and necessary product information and instructions are provided.

2. A Chinese medicinal ointment for treating diabetic ulcer and a preparation method according to claim 1, characterized in that: The proportion of the raw materials in S1 is 10-30 parts of Prunus mume seeds, 5-20 parts of Atractylodes lancea, 5-15 parts of rice sprouts, and 5-15 parts of Magnolia officinalis.

3. A Chinese medicinal ointment for treating diabetic ulcer and a preparation method according to claim 1, characterized in that: The crushing or slicing process in step S2 is performed by mechanical crushing or manual slicing to ensure that the particle size of the raw materials is uniform and easy to extract.

4. A Chinese medicinal ointment for treating diabetic ulcer and a preparation method according to claim 1, characterized in that: The soaking extraction in step S3 adopts water extraction or alcohol extraction, and the selection and dosage of the solvent need to be determined according to the properties of the raw materials and the extraction efficiency.

5. A Chinese medicinal ointment for treating diabetic ulcer and a preparation method according to claim 1, characterized in that: The decoction time in step S4 should be adjusted according to the properties of the raw materials and the extraction efficiency, and is generally 1 to 3 hours. The decoction process in step S4 needs to control the heat and time to avoid the effective ingredients in the medicinal materials from being destroyed or lost.

6. A Chinese medicinal ointment for treating diabetic ulcer and a preparation method according to claim 1, characterized in that: The auxiliary materials in step S4 include a matrix material, a moisturizing agent, and a preservative. The matrix material may be vaseline, beeswax, etc., the moisturizing agent may be glycerin, hyaluronic acid, etc., and the preservative may be sodium benzoate, potassium sorbate, etc.

7. A Chinese medicinal ointment for treating diabetic ulcer and a preparation method according to claim 1, characterized in that: The selection of auxiliary materials in step S5 needs to take into account the stability, ease of use and patient acceptance of the ointment.

8. A Chinese medicinal ointment for treating diabetic ulcer and a preparation method according to claim 1, characterized in that: The packaging process in step S6 must follow the principle of aseptic operation to ensure the sanitary quality of the ointment during the packaging process.