Cosmetic film dosage form analysis method based on PDMS

Abstract

The present specification discloses a cosmetic film coated on a polymer substrate having physical properties similar to those of the skin, for the degree of deformation of the substrate by coating the cosmetic composition, by means of X-ray CT (computed tomography), X-ray CT (computed tomography), X-ray CT, X-ray CT, X-ray CT, X-ray CT, X-ray CT, X-ray CT, X-ray CT, X-ray CT, X-ray CT, X-ray CT, and X-ray CT. According to the present invention, a technique for quantifying the characteristics of a cosmetic film dosage form by using a non-destructive analysis technique is provided, and the degree of tension of a cosmetic film can be objectively quantified by using the technique described above.

Description

Technical Field

[0001] The present specification relates to a cosmetic film dosage form analysis method, which utilizes a polymer substrate having physical properties similar to those of the skin, and quantifies the degree of substrate deformation of a cosmetic film coated on the polymer substrate using X-ray CT (computed tomography) and non-destructive analysis technology. Background Art

[0002] Conventionally, there is no technology for quantifying the degree of skin deformation or skin tightening caused by cosmetic masks based on existing dosage forms, and professional panels or customers have subjectively judged the degree of tightening or quantified it.

[0003] For this kind of subjective evaluation, even if systematic training is conducted with groups or customers, there will be individual differences because each user has a different reference point for the degree of tension they feel, and the result value will be affected by environmental factors (fatigue, weather, etc.). Therefore, although it is possible to compare products relatively, it is difficult to rely on absolute values.

[0004] Therefore, it is required to develop a technology that can quantify the changes in the physical properties of cosmetic film dosage forms. Summary of the invention

[0005] Technical issues to be solved

[0006] One aspect of the present invention is to provide an objective cosmetic film formulation evaluation method using a PDMS substrate having a strength (or elasticity, stiffness) similar to that of actual skin.

[0007] One aspect of the present invention is to provide a method for quantifying the properties of a cosmetic film dosage form by non-destructively analyzing a sample using X-ray CT.

[0008] Solution to the problem

[0009] On the one hand, the present specification provides a method for analyzing a cosmetic film dosage form based on PDMS (polydimethylsiloxane), the method comprising: a step of preparing a PDMS substrate; a step of applying a cosmetic composition to the PDMS substrate to form a cosmetic film; and a step of analyzing the degree of deformation of the PDMS substrate on which the cosmetic film is formed using X-ray CT.

[0010] Effects of the Invention

[0011] According to the method of one aspect of the present invention, the degree of tension of the cosmetic film can be objectively quantified.

[0012] According to the method of one aspect of the present invention, a cosmetic film dosage form can be analyzed non-destructively. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 As a schematic diagram of an implementation example according to the present invention, a cosmetic film is applied to a PDMS substrate to which a micropillar array is applied.

[0014] Figure 2a is a schematic diagram of Formula 1 (Poisson's ratio) according to an implementation example of the present invention, Figure 2b is an X-ray tomography image of PDMS with a micropillar array according to an embodiment of the present invention.

[0015] Figure 3 It is an X-ray CT imaging cross section (side view) of samples (#01, #04, #10, #11) according to one embodiment of the present invention.

[0016] Figure 4a is a result of measuring the cosmetic film coverage obtained by cross-sectional slicing of an X-ray CT image according to an embodiment of the present invention, Figure 4b 1 is a result of measuring the deformation rate of PDMS obtained by slicing a cross section of an X-ray CT image according to an embodiment of the present invention.

[0017] Figure 5a is a schematic diagram showing the pressure (strain) generated on the pillars by coating a micro-pillar pattern PDMS artificial skin model and a cosmetic film (foundation liquid) according to an implementation example of the present invention, Figure 5b is a schematic diagram of an image collection process of an X-ray CT imaging technique according to an embodiment of the present invention, Figure 5c 1 is a diagram showing an example of a cross section of a microcolumn covered with a cosmetic film (liquid foundation) according to an embodiment of the present invention and a three-dimensional reconstruction of the sample.

[0018] Figure 6a Optical microscope photos of the microcolumn artificial skin before and after spin coating of liquid foundation according to an embodiment of the present invention show that a makeup film is deposited on the microcolumn structure. Figure 6b As a case of showing the imaging position of the sample according to an embodiment of the present invention, the center C and the edge E of the makeup film are shown. DETAILED DESCRIPTION

[0019] The present invention is further described below by the following examples. However, the following examples are provided only for the purpose of helping to understand the present invention and are provided only as examples, and the category and scope of the present invention are not limited thereto.

[0020] In the present specification, when it is mentioned that a certain part “includes” certain constituent elements, unless there is a particular description to the contrary, it does not exclude other constituent elements, but means that other constituent elements may also be included.

[0021] Hereinafter, the present invention will be described in detail.

[0022] In an exemplary implementation of the present invention, a method for analyzing a cosmetic film dosage form based on PDMS (polydimethylsiloxane) is provided, the method comprising: a step of preparing a PDMS substrate; a step of applying a cosmetic composition to the PDMS substrate to form a cosmetic film; and a step of analyzing the degree of deformation of the PDMS substrate on which the cosmetic film is formed using X-ray CT.

[0023] According to the present disclosure, the degree of substrate deformation of a cosmetic film coated on a polymer substrate (PDMS (poly(dimethyl siloxane)) having physical properties similar to those of the skin can be quantified by using non-destructive analysis technology using X-ray CT, and the degree of tension of the cosmetic film can be quantified by measuring the coverage of the cosmetic film or the degree of PDMS deformation (refer to Figure 1 and Figure 5a ).

[0024] In one implementation example, a micropillar pattern may be formed on the upper portion of the PDMS substrate.

[0025] According to the present disclosure, by forming a micropillar array pattern that can replace the role of wrinkles and pores on a PDMS substrate having strength (or stiffness) similar to that of actual skin, it is possible to evaluate the characteristics of a cosmetic film formulation similar to the case of evaluating a cosmetic film on actual skin.

[0026] In one implementation example, the micro-pillars may be in the form of grooves (valleys) between the pillars, but the shape of each pillar is not particularly limited. Each pillar may be arranged radially at a certain interval from each other, for example, the intervals between the pillars may be the same.

[0027] In one implementation example, the micro-pillar pattern is a pattern of cylindrical pillars arranged in a hexagonal pattern. The height of each pillar may be 20 to 200 μm and the diameter may be 20 to 200 μm.

[0028] In one implementation example, the interval between pillars of the micro-pillar pattern may be 50 to 500 μm.

[0029] For example, the height may be greater than or equal to 20 μm, greater than or equal to 50 μm, greater than or equal to 100 μm, or greater than or equal to 150 μm, or less than or equal to 200 μm, less than or equal to 150 μm, less than or equal to 100 μm, or less than or equal to 50 μm.

[0030] For example, the diameter may be greater than or equal to 20 μm, greater than or equal to 50 μm, greater than or equal to 100 μm, or greater than or equal to 150 μm, and may be less than or equal to 200 μm, less than or equal to 150 μm, less than or equal to 100 μm, or less than or equal to 50 μm.

[0031] For example, the interval may be greater than or equal to 50 μm, greater than or equal to 100 μm, greater than or equal to 200 μm, or less than or equal to 300 μm, or less than or equal to 500 μm, less than or equal to 400 μm, less than or equal to 300 μm, or less than or equal to 200 μm.

[0032] For example, the height*diameter*pitch of the pillars may be 100 μm*100 μm*100 μm.

[0033] In one implementation example, the cosmetic composition may be in the form of any one or more of liquid, powder and solid.

[0034] In one implementation example, in the step of analyzing the deformation degree of the PDMS substrate, the tension degree of the cosmetic film can be quantified.

[0035] In one implementation example, in the step of analyzing the deformation degree of the PDMS substrate, X-rays with a power of 10 KeV or above may be transmitted for analysis.

[0036] For example, in the present disclosure, X-rays above 10 KeV or above 300 KeV may be transmitted to analyze the deformation degree of the PDMS substrate.

[0037] When less than 10 KeV X-rays are transmitted, the resolution may be reduced. That is, when the intensity is reduced, the ability to transmit PDMS may be reduced, and only the top portion of PDMS may be measured, and the valley region may not be measured.

[0038] However, it is possible to measure by transmitting various ranges of X-rays by changing the PDMS thickness or adjusting the sample size.

[0039] For example, a cosmetic composition sample can be coated on a PDMS substrate formed with a micro-column pattern having properties similar to those of actual skin, and then rotated 180 degrees, and X-rays having an energy of 30 KeV or more (or 10 KeV or more) are transmitted, and after taking two-dimensional vertical images at each certain angle, the images are combined through a computer program to produce a three-dimensional image.

[0040] Then, a desired portion of the obtained three-dimensional image can be intercepted by a program, and the cross section can be observed, and the degree or thickness of the sample coating can be confirmed with the naked eye.

[0041] In one implementation example, in the step of analyzing the deformation degree of the PDMS substrate, the thickness of the cosmetic composition coated on the top of the pillars and the thickness of the cosmetic composition coated in the valleys between the pillars can be measured.

[0042] In one implementation example, in the step of analyzing the deformation degree of the PDMS substrate, the deformation rate value v (reference Figure 1 and Figure 2a-2b ):

[0043] [Formula 1]

[0044] v=-ε lateral / ε longitudinal

[0045] In the above formula 1, ε longitudinal =(H d -H0) / H0,ε lateral =(D d -D0) / D0,

[0046] D0 is the diameter of the column before the cosmetic film is formed.

[0047] H0 is the height of the column before the cosmetic film is formed.

[0048] D d is the diameter of the column after the cosmetic film is formed,

[0049] H d It is the height of the column after the cosmetic film is formed.

[0050] In the above formula, the values ​​D0 and H0 of the pillars before the cosmetic film is formed are almost the same with no error. This is because the pillars are printed by patterning, so the heights or diameters of the pillars are almost the same at the initial stage.

[0051] However, the value D after the cosmetic film is formed d , H dSince the amount of cosmetic film applied is different, considering that the deformation rate value is different at each position, all the values ​​of the column can be digitized and inserted as data.

[0052] For example, the D d or H d The values ​​can be quantified using the custom imaging analysis program present in the accelerator and Avizo Software.

[0053] In yet another exemplary implementation of the present invention, an artificial skin for analyzing cosmetic film dosage forms is provided, which includes a PDMS (polydimethylsiloxane) substrate having a microcolumn pattern formed on the upper portion.

[0054] In one implementation example, the micro-pillar pattern is a pattern of cylindrical pillars arranged in a hexagonal pattern. The height of each pillar may be 20 to 200 μm and the diameter may be 20 to 200 μm.

[0055] In one implementation example, the cosmetic film dosage form analysis may be to analyze the deformation degree of the PDMS substrate on which the cosmetic film is formed by using X-ray CT after the cosmetic composition is applied on the artificial skin.

[0056] In one implementation example, the cosmetic composition may be in the form of any one or more of liquid, powder and solid.

[0057] In one implementation example, the cosmetic film dosage form analysis may be to quantify the degree of tension of the cosmetic film.

[0058] In one implementation example, the cosmetic film dosage form analysis may be performed by transmitting X-rays of 10 KeV or more.

[0059] In one implementation example, the cosmetic film dosage form analysis may be performed by measuring the thickness of the cosmetic composition coated on the top of a column; and analyzing the thickness of the cosmetic composition coated in the valley between columns.

[0060] In one implementation example, the cosmetic film dosage form analysis may be performed by calculating the deformation rate value v according to the following formula 1:

[0061] [Formula 1]

[0062] v=-ε lateral / ε longitudinal

[0063] In the above formula 1, ε longitudinal =(H d -H0) / H0,ε lateral =(Dd -D0) / D0,

[0064] D0 is the diameter of the column before the cosmetic film is formed.

[0065] H0 is the height of the column before the cosmetic film is formed.

[0066] D d is the diameter of the column after the cosmetic film is formed,

[0067] H d It is the height of the column after the cosmetic film is formed.

[0068] The present invention is further described in detail below by way of examples. These examples are only used to illustrate the present invention, and the scope of the present invention is not limited by these examples, which is self-evident to those with ordinary knowledge in the art.

[0069] Example

[0070] (1) Experimental Materials and Methods

[0071] Artificial skin substrate

[0072] For this study, micro-pillar (micro-column) patterned substrates were made to simulate the skin surface. The substrates were made of polydimethylsiloxane (PDMS) using the SYLGARDTM 184 silicone elastomer kit (Dow, USA). The polymer base and curing agent were mixed in a ratio of 20:1 to obtain a rigidity in the same range as the actual skin strength (about 210 kPa). The polymer mixture was poured into a silicone master mold designed with cylindrical pillars (diameter D = 100 μm, height H = 100 μm, spacing P = 100 μm) arranged in a hexagonal pattern. After curing the polymer in a convection oven at 75°C for 4 hours, it was gently released from the master mold. The resulting substrate has hydrophobic properties, which is a necessary feature because mammalian skin is also hydrophobic. The micro-pillars (micro-columns) help to create a roughness similar to the natural wrinkles and pores of the skin.

[0073] Application of cosmetic samples

[0074] In this study, various liquid foundation formulations were analyzed for quantitative comparison of makeup film deposition. In the study, product samples 1, 4, 10, and 11 were tested. Micropillar artificial skin was sheared in a 1 cm x 1 cm regular quadrilateral, and the base material was applied using a spin coater at 1750 RPM for 60 seconds. Spin coating is a standard method for obtaining thin film deposition similar to the coverage predicted when the liquid foundation is applied to the actual skin surface ( Figure 6a ).

[0075] No. 1 and No. 4 are commercially available products, and No. 10 and No. 11 are trial products made of the same raw materials as the commercially available product No. 1.

[0076] X-ray microtomography

[0077] In order to characterize and differentiate various foundation samples, we present a quantitative analysis of cosmetic coatings using X-ray computed tomography. Synchrotron source X-ray imaging experiments were performed using the 6C BMI (BioMedical Imaging) beamline at the Pohang Light Source II (PLS-II). The machine has equipment capable of achieving phase difference imaging using hard X-rays (λ ~ 0.1 nm), which have the characteristic of being advantageous for the visualization of thick opaque media. For complete imaging of the microcolumn structure and the deposited cosmetic film, the beam used was characterized by monochromatic X-rays set at a high energy of 37 keV.

[0078] As in Figure 5b As shown schematically in Figure 1, the sample in the rotation step configuration is transmitted by X-rays converted into visible light by a scintillator (LuAG:Ce 50μm) and then received by a scientific complementary metal-oxide-semiconductor (sCMOS) camera (pco.edge). All experiments were performed at 10x magnification of 1.70x1.40mm2 (pixel size: 0.65μm) to provide a wide field of view.

[0079] For the three-dimensional analysis of the sample, X-ray computed tomography (CT) was performed. During the rotation of the sample from 0 to 180 degrees, 2D projection images were recorded using the Octopus Reconstruction program (Octopus, Belgium) and converted into two-dimensional tomographic slices. Then, using these 2D slices, the three-dimensional sample was reconstructed using Avizo visualization software (Thermo Fisher Scientific, USA), and the 3D reconstruction and 2D cross-sections were observed from multiple directions ( Figure 5c ).

[0080] The sample was imaged at two locations. One at the center of the makeup film deposition and one at the edge of the makeup film ( Figure 6b ). For the parameters analyzed in the 3D reconstruction for each sample, Figure 1 Schematize the central and edge positions of the image.

[0081] To analyze the cosmetic foundation film, two parameters were measured: the thickness Tt of the cosmetic material deposited on the top of the pillars and the thickness Tv of the cosmetic material deposited in the valleys between the pillars.

[0082] In order to confirm the stress applied to the artificial skin due to the deposition of the cosmetic film, the diameter D of the deformed pillars was also measured. d and the height H of the deformed column d The size of the deformed micropillars. Each parameter was measured 15 times in total at each location and sample. The 3D microtomographic analysis allows the precise measurement of sample dimensions and confirmation of the film thickness and deformation that occurred.

[0083] (2) Side view of the sample after cosmetic film coating

[0084] refer to Figure 3 , it can be confirmed that the cross-section (center side view) of the samples (#01, #04, #10, #11) manufactured in (1) was photographed by X-ray CT.

[0085] By referring to these figures, a two-dimensional or three-dimensional image showing the internal structure or density of the cosmetic film of each manufactured sample can be obtained. From the cross-sectional view, it can be confirmed that formulations #01, #10, and #11 containing the same ingredients show similar coverage morphology of the cosmetic film, and #04, which is our company's representative formulation and contains other ingredients, has a coverage morphology different from the remaining three samples.

[0086] (3) Cosmetic film coverage

[0087] like Figure 4a As shown, by measuring the thickness Tt of the cosmetic material deposited on the top of the pillars (Pillar Top) of the samples (#01, #04, #10, #11) manufactured in (1) and the thickness Tv (Valley) of the cosmetic material deposited in the valleys between the pillars, the coverage of the cosmetic film after coating is estimated.

[0088] With reference to these, it can be confirmed that the degree of deposition on the top of the column (Tt) and the degree of deposition in the valley (Tv) are the highest in #04, and the remaining samples #01, #10, and #11 containing the same components are formed to similar thicknesses. The difference is 10um, which shows that a considerable difference has occurred. At the same time, it is a result that can be confirmed that the degree of deposition is different depending on the components contained in the sample. In addition, by comparing #01, #10, and #11, it is confirmed that although they contain the same components, there is still a slight difference in thickness depending on the content.

[0089] (4) PDMS deformation rate after cosmetic film coating

[0090] The PDMS deformation rate of the samples (#01, #04, #10, #11) manufactured in (1) was calculated according to the following formula 1, so that Figure 4b As shown, illustrated by a diagram.

[0091] [Formula 1]

[0092] v=-ε lateral / ε longitudinal

[0093] In the above formula 1, ε longitudinal =(H d -H0) / H0,ε lateral =(D d -D0) / D0,

[0094] D0 is the diameter of the column before the cosmetic film is formed.

[0095] H0 is the height of the column before the cosmetic film is formed.

[0096] D d is the diameter of the column after the cosmetic film is formed,

[0097] H d It is the height of the column after the cosmetic film is formed.

[0098] In the above formula 1, the calculation is performed with D0 being 100 um and H0 being 100 um.

[0099] refer to Figure 4b , the PDMS basic Poisson's ratio (value of Formula 1) has a value between 0.4 and 0.5 (red dashed box). The values ​​shown here all represent the Poisson's ratio values ​​of each PDMS column, and the chart lists 9 to 10 values ​​for each sample.

[0100] In the case of #04, the Poisson's ratio is lower than the value of the Poisson's ratio of the base PDMS. This means that even if the cosmetic film is applied, the PDMS is not deformed. In particular, when confirming the previous coverage data, #04 did not cause PDMS deformation even when the thickest coating was applied at the top of the column and the valley. From this, it can be predicted that when actually applied to the skin, even if the dosage form is applied with a sense of thickness, the user may not feel the tightening feeling. However, when the applied coverage image is fully observed, it is confirmed that the surface roughness is uneven compared to other dosage forms, and it is predicted that from the user's standpoint, the applied dosage form may feel lack of smoothness.

[0101] In contrast, as observed in the coverage image, #01, #10, and #11 were all smooth and evenly coated. However, #01 was observed to have a higher PDMS Poisson's ratio than the other samples, so it was predicted that the user would feel a strong sense of tension. In order to overcome this, the formulations of #10 and #11 were designed in a direction of alleviating the tension by adjusting the content of the component that causes the tension.

[0102] Finally, it was confirmed that #11 was the appropriate formulation that caused the least deformation of PDMS while making the cosmetic film uniformly distributed. In addition, it was confirmed that a certain degree of tension was required in order to apply it evenly on the skin.

[0103] Specific example

[0104] Specific example 1: A cosmetic film formulation analysis method based on PDMS (poly(dimethyl siloxane)), the method comprising:

[0105] Steps for preparing PDMS substrates;

[0106] A step of applying a cosmetic composition onto the PDMS substrate to form a cosmetic film; and

[0107] A step of analyzing the degree of deformation of the PDMS substrate on which the cosmetic film is formed using X-ray CT.

[0108] Specific example 2: A method according to specific example 1, wherein a micropillar pattern is formed on the upper portion of the PDMS substrate.

[0109] Specific example 3: A method, according to specific example 1 or 2, wherein the micro-pillar pattern is a cylindrical pillar arranged in a hexagonal regular pattern,

[0110] Each of the pillars has a height of 20 to 200 μm and a diameter of 20 to 200 μm.

[0111] Specific example 4: A method, according to any one of specific examples 1 to 3, wherein the cosmetic composition includes any one or more forms of liquid, powder and solid.

[0112] Specific example 5: A method, according to any one of specific examples 1 to 4, in the step of analyzing the degree of deformation of the PDMS substrate, the degree of tension of the cosmetic film is quantified.

[0113] Specific example 6: A method, according to any one of specific examples 1 to 5, in the step of analyzing the deformation degree of the PDMS substrate, the analysis is performed by transmitting X-rays above 10KeV.

[0114] Specific example 7: A method, according to any one of specific examples 1 to 6, in the step of analyzing the degree of deformation of the PDMS substrate, measuring the thickness of the cosmetic composition coated on the top of the pillar; and the thickness of the cosmetic composition coated in the valley between the pillars.

[0115] Specific example 8: A method, according to any one of specific examples 1 to 7, in the step of analyzing the deformation degree of the PDMS substrate, the deformation rate value v is calculated according to the following formula 1:

[0116] [Formula 1]

[0117] v=-ε lateral / ε longitudinal

[0118] In the above formula 1, ε longitudinal =(H d -H0) / H0,ε lateral =(D d -D0) / D0,

[0119] D0 is the diameter of the column before the cosmetic film is formed.

[0120] H0 is the height of the column before the cosmetic film is formed.

[0121] D d is the diameter of the column after the cosmetic film is formed,

[0122] H d It is the height of the column after the cosmetic film is formed.

[0123] Specific example 9: A use as an artificial skin for cosmetic film dosage form analysis, wherein the artificial skin comprises PDMS (polydimethylsiloxane) having a micro-column pattern formed on the upper portion;

[0124] poly(dimethyl siloxane)) substrate.

[0125] Specific example 10: A use, according to specific example 9, the micro-pillar pattern is cylindrical pillars arranged in a hexagonal regular pattern,

[0126] Each of the pillars has a height of 20 to 200 μm and a diameter of 20 to 200 μm.

[0127] Specific example 11: A use according to specific example 9 or 10, wherein the cosmetic film dosage form analysis is to analyze the deformation degree of the PDMS substrate on which the cosmetic film is formed by using X-ray CT after applying the cosmetic composition onto the artificial skin.

[0128] Specific example 12: A use, according to any one of specific examples 9 to 11, the cosmetic composition includes any one or more forms of liquid, liquid foundation and solid.

[0129] Specific example 13: A use according to any one of specific examples 9 to 12, wherein the cosmetic film dosage form analysis is to quantify the degree of tension of the cosmetic film.

[0130] Specific example 14: A use according to any one of specific examples 9 to 13, wherein the cosmetic film dosage form analysis is performed by transmitting X-rays of 10 KeV or above.

[0131] Specific example 15: A use, according to any one of specific examples 9 to 14, the cosmetic film dosage form analysis is to measure the thickness of the cosmetic composition coated on the top of the column; and analyze the thickness of the cosmetic composition coated in the valley between the columns.

[0132] Specific example 16: A use, according to any one of specific examples 9 to 15, the cosmetic film dosage form analysis is performed by calculating the deformation rate value v according to the following formula 1:

[0133] [Formula 1]

[0134] v=-ε lateral / ε longitudinal

[0135] In the above formula 1, ε longitudinal =(H d -H0) / H0,ε lateral =(D d -D0) / D0,

[0136] D0 is the diameter of the column before the cosmetic film is formed.

[0137] H0 is the height of the column before the cosmetic film is formed.

[0138] D d is the diameter of the column after the cosmetic film is formed,

[0139] H d It is the height of the column after the cosmetic film is formed.

Claims

1. A cosmetic film formulation analysis method based on PDMS, the method comprising: Steps for preparing PDMS substrates; A step of applying a cosmetic composition onto the PDMS substrate to form a cosmetic film; as well as A step of analyzing the degree of deformation of the PDMS substrate on which the cosmetic film is formed using X-ray CT.

2. The method according to claim 1, wherein: The PDMS substrate has a micro-column pattern formed on the upper portion.

3. The method according to claim 2, wherein: The micro-pillar pattern is composed of cylindrical pillars arranged in a hexagonal pattern. Each of the pillars has a height of 20 to 200 μm and a diameter of 20 to 200 μm.

4. The method according to claim 1, wherein: The cosmetic composition includes any one or more forms of liquid, powder and solid.

5. The method according to claim 1, wherein: In the step of analyzing the deformation degree of the PDMS substrate, the tension degree of the cosmetic film is quantified.

6. The method according to claim 1, wherein: In the step of analyzing the deformation degree of the PDMS substrate, X-rays with a voltage of 10 KeV or above are transmitted for analysis.

7. The method according to claim 2, wherein: In the step of analyzing the degree of deformation of the PDMS substrate, The thickness of the cosmetic composition coated on the upper part of the pillars and the thickness of the cosmetic composition coated in the valleys between the pillars are measured.

8. The method according to claim 2, wherein: In the step of analyzing the deformation degree of the PDMS substrate, the deformation rate value (v) is calculated according to the following formula 1: [Formula 1] v=-e lateral / e longitudinal In the above formula 1, ε longitudinal =(H d -H0) / H0,ε lateral =(D d -D0) / D0, D0 is the diameter of the column before the cosmetic film is formed. H0 is the height of the column before the cosmetic film is formed. D d is the diameter of the column after the cosmetic film is formed, H d It is the height of the column after the cosmetic film is formed.

9. A use as an artificial skin for cosmetic film dosage form analysis, the artificial skin comprising a PDMS substrate with a micro-pillar pattern formed on the upper portion.

10. The use according to claim 9, wherein The micro-pillar pattern is composed of cylindrical pillars arranged in a hexagonal pattern. Each of the pillars has a height of 20 to 200 μm and a diameter of 20 to 200 μm.

11. The use according to claim 9, wherein The cosmetic film formulation analysis is to analyze the deformation degree of the PDMS substrate on which the cosmetic film is formed by using X-ray CT after applying the cosmetic composition on the artificial skin.

12. The use according to claim 11, wherein The cosmetic composition may be in any one or more forms of liquid, powder and solid.

13. The use according to claim 9, wherein The cosmetic film dosage form analysis is to quantify the degree of tightening of the cosmetic film.

14. The use according to claim 9, wherein The cosmetic film dosage form analysis is performed by transmitting X-rays above 10 KeV.

15. The use according to claim 10, wherein The cosmetic film formulation analysis is performed by measuring the thickness of the cosmetic composition applied on the upper part of the pillars; and the thickness of the cosmetic composition applied in the valleys between the pillars.

16. The use according to claim 10, wherein The cosmetic film formulation analysis is performed by calculating the deformation rate value (v) according to the following formula 1: [Formula 1] v=-e lateral / e longitudinal In the above formula 1, ε longitudinal =(H d -H0) / H0,ε lateral =(D d -D0) / D0, D0 is the diameter of the column before the cosmetic film is formed. H0 is the height of the column before the cosmetic film is formed. D d is the diameter of the column after the cosmetic film is formed, H d This is the height of the column after the cosmetic film is formed.

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