Brain electrode

Abstract

The invention relates to the technical field of medical instruments, in particular to a brain electrode which comprises an electrode body, a signal receiving circuit, a signal processing circuit, a signal processing circuit and a signal processing circuit, and is characterized in that the electrode body comprises a signal acquisition end and a conduction part; the electrode tray wraps the side surface of the conduction part; the flexible shell wraps the electrode body and the electrode tray and is provided with an opening for exposing the signal acquisition end; the electrode tray is used for fixing the position of the electrode body in the flexible shell; the brain electrode can effectively solve the problem that due to the fact that the mechanical property difference between the brain electrode and the brain tissue is too large, the brain tissue is prone to being damaged when the brain electrode is inserted into the brain.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to a brain electrode. Background Art

[0002] Brain electrodes are widely used in the fields of neuroscience, brain-computer interface, epilepsy treatment and deep brain stimulation for Parkinson's disease. The materials of related brain electrodes are metal materials or carbon-based materials. Since metal materials and carbon-based materials have too large a difference in mechanical properties with brain tissue, the related technology has the problem of easily causing damage to brain tissue when inserting brain electrodes into the brain.

[0003] There is no effective technical solution to the above problems. It should be noted that the above information disclosed in this section is only used to understand the background of the present invention, and therefore may contain information that does not constitute prior art. Summary of the invention

[0004] The purpose of the present application is to provide a brain electrode that can effectively solve the problem that the brain tissue is easily damaged when the brain electrode is inserted into the brain due to the large difference in mechanical properties between the brain electrode and the brain tissue.

[0005] The present application provides a brain electrode, which includes: The electrode body comprises a signal collection end and a conducting part, wherein one end of the conducting part away from the signal collection end is connected to a signal receiving circuit; An electrode tray, wrapping the side of the conductive part; A flexible housing, which wraps the electrode body and the electrode tray and has an opening for exposing the signal collection end; The electrode tray is used to fix the position of the electrode body in the flexible housing.

[0006] The present application provides a brain electrode that can reduce the difference in mechanical properties between the brain electrode and brain tissue by disposing a flexible shell outside the electrode body. Therefore, the present application can effectively solve the problem that the brain tissue is easily damaged when the brain electrode is inserted into the brain due to the large difference in mechanical properties between the brain electrode and the brain tissue.

[0007] Optionally, the cross-section of the flexible housing is circular, and a plurality of barb groups are arranged in a circumferential array on the outer circumference of the flexible housing, and each barb group includes a plurality of barb structures inclined away from the signal collection end.

[0008] This technical solution is equivalent to making the flexible shell have a mosquito-like mouthpart structure by means of a plurality of barb groups arranged in a circular array on the outer circumference of the flexible shell. Since the mosquito-like mouthpart structure has the characteristic of reducing the friction during insertion, that is, this technical solution can make the flexible shell have a friction-reducing effect, so this technical solution can effectively reduce the puncture force and interface friction when the brain electrode is inserted into the brain, thereby effectively reducing the mechanical damage to the brain tissue when the brain electrode is inserted into the brain and avoiding the occurrence of inflammatory reactions and scar formation as much as possible, that is, this technical solution provides a better working environment for the brain electrode, thereby effectively improving the stability of the brain electrode.

[0009] Optionally, an angle between an extension direction of the barb structure and an extension direction of the flexible shell is 25°-50°.

[0010] This technical solution sets the angle between the extension direction of the barb structure and the extension direction of the flexible shell to 25°-50°, thereby avoiding the situations where the friction-reducing effect of the flexible shell is reduced due to the angle between the extension direction of the barb structure and the extension direction of the flexible shell is too large, the resistance to the brain electrodes when inserted into the brain is increased, and the risk of mechanical damage to the brain tissue is increased, and the processing difficulty of the flexible shell is too great and the friction-reducing effect of the flexible shell is reduced due to the angle between the extension direction of the barb structure and the extension direction of the flexible shell is too small.

[0011] Optionally, a ratio of the sum of the root lengths of the barb structures in the same barb group to the length of the flexible shell is greater than 0.5.

[0012] This technical solution is equivalent to making the same barb group contain sufficient barb structures by making the ratio of the sum of the root lengths of the barb structures in the same barb group to the length of the flexible shell greater than 0.5. Therefore, this technical solution can effectively avoid the situation where the friction reduction effect of the flexible shell is not obvious due to the fact that the same barb group contains too few barb structures.

[0013] Optionally, a micro-nano array structure is provided on the outer surface of the flexible shell.

[0014] The technical solution makes the flexible shell super-hydrophobic by arranging a micro-nano array structure on the outer surface of the flexible shell. Therefore, the technical solution can reduce the occurrence of protein adsorption or biological contamination, as well as the oxidation, degradation or cross-linking reaction of the flexible shell caused by long-term exposure of the flexible shell to the complex biochemical environment in the brain, thereby avoiding as much as possible the inflammatory reaction caused by protein adsorption or biological contamination and the decrease in the mechanical properties and chemical stability of the flexible shell due to oxidation, degradation or cross-linking reaction of the flexible shell. Since the flexible shell of the technical solution has super-hydrophobicity, the super-hydrophobicity can make a stable air film exist on the surface of the flexible shell when the brain electrode is inserted into the brain. The air film can prevent the flexible shell from directly contacting the brain tissue, that is, the technical solution can produce a slip effect between the flexible shell and the brain tissue when the brain electrode is inserted into the brain. Therefore, the technical solution can also effectively reduce the friction between the brain electrode and the brain tissue when the brain electrode is inserted into the brain, thereby effectively avoiding the excessive damage to the brain electrode due to excessive friction between the brain electrode and the brain tissue when the brain electrode is inserted into the brain.

[0015] Optionally, the barbed structure retracts away from the flexible housing.

[0016] Optionally, the brain electrode further includes a vibration module, which is connected to an end of the conduction part away from the signal collection end, and the vibration module is used to make the flexible shell vibrate periodically through the electrode body when the brain electrode is inserted into the brain tissue.

[0017] Since this technical solution can utilize the vibration module to make the flexible shell vibrate periodically when the brain electrode is inserted into the brain tissue, and the inertial force generated by the periodic vibration can increase the rigidity of the flexible shell and cause changes in the gap between the flexible shell and the brain tissue, this technical solution can effectively reduce the difficulty and penetration force of the flexible shell piercing the brain tissue.

[0018] Optionally, the vibration frequency of the vibration module is 5-15 Hz, and the amplitude of the vibration module is 2-8 μm.

[0019] Optionally, the vibration module includes a vibration element, a signal amplifier and a signal generator, the signal generator is connected to the input end of the signal amplifier, the output end of the signal amplifier is connected to the vibration element, the vibration element is connected to an end of the electrode body away from the signal collection end, the signal generator is used to output a vibration waveform, the signal amplifier is used to amplify the vibration waveform, and the vibration element is used to generate corresponding vibration according to the amplified vibration waveform.

[0020] Optionally, the electrode tray is made of ABS plastic.

[0021] From the above, it can be seen that the brain electrode provided by the present application can reduce the difference in mechanical properties between the brain electrode and the brain tissue by disposing a flexible shell outside the electrode body. Therefore, the present application can effectively solve the problem that the brain electrode is easily damaged when inserted into the brain due to the large difference in mechanical properties between the brain electrode and the brain tissue. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 A cross-sectional schematic diagram of a brain electrode provided in an embodiment of the present application.

[0023] Figure 2 A schematic diagram of the structure of a flexible housing provided in an embodiment of the present application.

[0024] Figure numerals: 1. electrode body; 101. signal acquisition end; 102. conduction part; 2. signal receiving circuit; 3. electrode tray; 4. flexible shell; 5. opening; 6. barb structure; 7. micro-nano array structure; 8. vibration module; 81. vibration element; 82. signal amplifier; 83. signal generator; 9. terminal; 10. puncture part. DETAILED DESCRIPTION

[0025] The technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all of the embodiments. The components of the embodiments of the present application described and shown in the drawings here can be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the application claimed for protection, but merely represents the selected embodiments of the present application. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without making creative work belong to the scope of protection of the present application.

[0026] It should be noted that similar reference numerals and letters represent similar items in the following drawings, so once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings. At the same time, in the description of this application, the terms "first", "second", etc. are only used to distinguish the description and cannot be understood as indicating or implying relative importance.

[0027] like Figure 1-Figure 2 As shown, the present application provides a brain electrode, which includes: The electrode body 1 includes a signal collection end 101 and a conducting part 102, wherein one end of the conducting part 102 away from the signal collection end 101 is connected to a signal receiving circuit 2; The electrode tray 3 wraps the side of the conductive part 102; A flexible shell 4, which wraps the electrode body 1 and the electrode tray 3, and has an opening 5 for exposing the signal collection end 101; The electrode tray 3 is used to fix the position of the electrode body 1 in the flexible shell 4 .

[0028] The electrode body 1 of this embodiment can be an existing brain electrode, and the material of the electrode body 1 can be a metal material or a carbon-based material. The electrode body 1 includes a signal acquisition terminal 101 for collecting signals (such as EEG signals) and a conductive part 102 for transmitting the collected signals. The signal receiving circuit 2 of this embodiment can be an existing circuit, and the signal receiving circuit 2 is connected to the end of the conductive part 102 away from the signal acquisition terminal 101. The signal receiving circuit 2 can collect the signal collected by the signal acquisition terminal 101 to facilitate the subsequent analysis and processing of the collected signal. Preferably, the signal receiving circuit 2 of this embodiment is connected to the end of the conductive part 102 away from the signal acquisition terminal 101 through the wiring terminal 9. The electrode tray 3 of this embodiment wraps the side of the conductive part 102, and the electrode tray 3 is used to fix the position of the electrode body 1 in the flexible shell 4. Therefore, this embodiment effectively avoids the situation where the exposed area of ​​the signal acquisition terminal 101 changes due to the accidental displacement of the electrode body 1 in the flexible shell 4, and the signal acquisition of the brain electrode is affected. The flexible shell 4 of this embodiment wraps the electrode body 1 and the electrode tray 3, and the flexible shell 4 has an opening 5 for exposing the signal acquisition end 101. The material of the flexible shell 4 is preferably a flexible polymer (preferably PDMS, polydimethylsiloxane). The difference in mechanical properties between the flexible shell 4 of this embodiment and the brain tissue is smaller than the difference in mechanical properties between metal materials and carbon-based materials and the brain tissue, that is, the mechanical matching between the flexible shell 4 and the brain tissue is better than the mechanical matching between metal materials and carbon-based materials and the brain tissue. Therefore, this embodiment can effectively avoid the damage to the brain tissue when the brain electrode is inserted into the brain and reduce the accumulation of interface stress when the brain electrode is implanted in the brain for a long time by disposing the flexible shell 4 outside the electrode body 1, thereby effectively improving the comfort of the brain electrode implanter and the reliability of the brain electrode. It should be understood that since the exposed area of ​​the signal acquisition terminal 101 of this embodiment is related to the size of the opening 5, the signal acquisition range and signal detail richness of the signal acquisition terminal 101 are positively correlated with the exposed area of ​​the signal acquisition terminal 101, and under the influence of interference factors (such as electrical signals generated by peripheral nerve tissue and muscle activity, cell metabolism and ion concentration inside the brain), the signal acquisition quality of the signal acquisition terminal 101 is negatively correlated with the exposed area of ​​the signal acquisition terminal 101. Therefore, technical personnel in this field can change the size of the opening 5 according to actual needs for the signal acquisition range, signal detail richness and signal acquisition quality.

[0029] The present application provides a brain electrode that can reduce the difference in mechanical properties between the brain electrode and brain tissue by disposing a flexible shell 4 outside the electrode body 1. Therefore, the present application can effectively solve the problem that the brain tissue is easily damaged when the brain electrode is inserted into the brain due to the large difference in mechanical properties between the brain electrode and the brain tissue.

[0030] In some preferred embodiments, the cross-sectional shape of the flexible shell 4 is circular, and the outer circumferential array of the flexible shell 4 has multiple barb groups, and each barb group includes multiple barb structures 6 that are tilted away from the signal acquisition end 101. The number of barb groups in this embodiment is preferably two, and this embodiment is equivalent to making the flexible shell 4 imitate the structure of mosquito mouthparts by means of multiple barb groups in the outer circumferential array of the flexible shell 4. Since the structure of imitating mosquito mouthparts has the characteristic of reducing the friction force during insertion, that is, this embodiment can make the flexible shell 4 have a friction reduction effect, so this embodiment can effectively reduce the puncture force and interface friction when the brain electrode is inserted into the brain, thereby effectively reducing the mechanical damage to the brain tissue when the brain electrode is inserted into the brain and avoiding the occurrence of inflammatory reactions and scar formation as much as possible, that is, this embodiment provides a better working environment for the work of the brain electrode, thereby effectively improving the stability of the brain electrode.

[0031] In some preferred embodiments, the angle between the extension direction of the barb structure 6 and the extension direction of the flexible shell 4 is 25°-50°. This embodiment avoids the situation that the friction reduction effect of the flexible shell 4 is reduced due to the excessively large angle between the extension direction of the barb structure 6 and the extension direction of the flexible shell 4, the resistance to the brain electrode is increased when the brain electrode is inserted into the brain, and the risk of mechanical damage to the brain tissue is increased, and the processing difficulty of the flexible shell 4 is too large and the friction reduction effect of the flexible shell 4 is reduced due to the excessively small angle between the extension direction of the barb structure 6 and the extension direction of the flexible shell 4.

[0032] In some preferred embodiments, the ratio of the sum of the root lengths of the barb structures 6 in the same barb group to the length of the flexible shell 4 is greater than 0.5. This embodiment is equivalent to making the same barb group contain enough barb structures 6 by making the ratio of the sum of the root lengths of the barb structures 6 in the same barb group to the length of the flexible shell 4 greater than 0.5. Therefore, this embodiment can effectively avoid the situation where the friction reduction effect of the flexible shell 4 is not obvious due to too few barb structures 6 included in the same barb group.

[0033] Since the existing brain electrodes are made of metal materials or carbon-based materials, and both metal materials and carbon-based materials are hydrophilic, and under the effect of hydrophilicity, the brain electrodes inserted into the brain may be adsorbed by proteins or contaminated by organisms, the prior art also has the problem of inducing inflammatory reactions due to protein adsorption or biocontamination of the brain electrodes inserted into the brain. In order to solve this technical problem, in some preferred embodiments, the outer surface of the flexible shell 4 is provided with a micro-nano array structure 7. The micro-nano array structure 7 of this embodiment can be a micro-nano temperature adjustment array structure, a micro-nano grid array structure, or a micro-nano lattice structure. In this embodiment, the flexible shell 4 is made super-hydrophobic by arranging a micro-nano array structure 7 on the outer surface of the flexible shell 4. Therefore, this embodiment can reduce the occurrence of protein adsorption or biological contamination, as well as the oxidation, degradation or cross-linking reaction of the flexible shell 4 caused by long-term exposure of the flexible shell 4 to the complex biochemical environment in the brain, thereby avoiding as much as possible the occurrence of inflammatory reactions caused by protein adsorption or biological contamination, and the decrease in the mechanical properties and chemical stability of the flexible shell 4 caused by oxidation, degradation or cross-linking reactions of the flexible shell 4. Since the flexible shell 4 of this embodiment has super-hydrophobicity, the super-hydrophobicity can make a stable air film exist on the surface of the flexible shell 4 when the brain electrode is inserted into the brain, and the air film can prevent the flexible shell 4 from directly contacting the brain tissue, that is, this embodiment can generate a slip effect between the flexible shell 4 and the brain tissue when the brain electrode is inserted into the brain. Therefore, this embodiment can also effectively reduce the friction between the brain electrode and the brain tissue when the brain electrode is inserted into the brain, thereby effectively avoiding the excessive damage to the brain electrode caused by excessive friction between the brain electrode and the brain tissue when the brain electrode is inserted into the brain. It should be understood that the principle of making the flexible shell 4 super-hydrophobic by arranging the micro-nano array structure 7 on the outer surface of the flexible shell 4 in this embodiment is: the wetting state equation is: , wherein θ represents the contact angle of the droplet on the solid surface, f1 represents the area fraction of the droplet in contact with the solid surface, θ1 represents the intrinsic contact angle of the smooth surface, and f2 represents the area fraction of the droplet in contact with the air. Specifically, the intrinsic contact angle of the smooth surface of this embodiment is associated with the hydrophobicity of the material of the present application. Since the material of the flexible shell 4 of this embodiment is a flexible polymer, the flexible polymer is hydrophobic, that is, the flexible shell 4 of this embodiment is hydrophobic, so θ1 of this embodiment is greater than 90° and less than 180°, that is, cosθ1 is less than 0 and greater than -1. After the micro-nano array structure 7 is provided on the outer surface of the flexible shell 4, the micro-nano array structure 7 will reduce the direct contact area between the droplet and the solid surface and increase the contact area between the droplet and the air, that is, the f1 corresponding to the flexible shell 4 without the micro-nano array structure 7 is greater than the flexible shell 4 with the micro-nano array structure 7. The f1 corresponding to the flexible shell 4, the f2 corresponding to the flexible shell 4 without the micro-nano array structure 7 is greater than the f2 corresponding to the flexible shell 4 with the micro-nano array structure 7, and because f1 needs to be multiplied by cosθ1, and cosθ1 is less than 0 and greater than -1, the absolute value of the change in f1cosθ1 is less than the absolute value of the change in f2. Therefore, after the micro-nano array structure 7 is provided on the outer surface of the flexible shell 4, the value of f1cosθ1-f2 is negative and the value will become smaller, that is, after the micro-nano array structure 7 is provided on the outer surface of the flexible shell 4, the contact angle of the droplet on the solid surface will increase, thereby achieving super-hydrophobicity of the flexible shell 4 by providing the micro-nano array structure 7 on the outer surface of the flexible shell 4. Specifically, in this embodiment, the contact angle of the droplet on the surface of the flexible shell 4 is greater than 150° by providing the micro-nano array structure 7 on the outer surface of the flexible shell 4. Preferably, this embodiment uses femtosecond laser technology to form a micro-nano array structure 7 on the outer surface of the flexible shell 4. Specifically, the working parameters of the femtosecond laser technology of this embodiment include a wavelength of 800nm, a repetition frequency of 1kHz, a pulse width of 50fs, a spot width of 15μm, a laser scanning interval of 20μm and a laser scanning speed of 10mm / s.

[0034] In some preferred embodiments, the barb structure 6 is retracted away from the flexible housing 4. This embodiment increases the sharpness of the barb structure 6 by retracting the barb structure 6 away from the flexible housing 4, so this embodiment can effectively reduce the difficulty of inserting the brain electrode into the brain and increase the insertion depth of the brain electrode.

[0035] In some preferred embodiments, the brain electrode further comprises a vibration module 8, the vibration module 8 is connected to the end of the conduction part 102 away from the signal acquisition end 101, and the vibration module 8 is used to make the flexible shell 4 vibrate periodically through the electrode body 1 when the brain electrode is inserted into the brain tissue. Since this embodiment can use the vibration module 8 to make the flexible shell 4 vibrate periodically when the brain electrode is inserted into the brain tissue, and the inertial force generated by the periodic vibration can increase the rigidity of the flexible shell 4 and cause the gap between the flexible shell 4 and the brain tissue to change, this embodiment can effectively reduce the difficulty and penetration force of the flexible shell 4 piercing the brain tissue.

[0036] In some preferred embodiments, the vibration frequency of the vibration module 8 is 5-15 Hz, and the amplitude of the vibration module 8 is 2-8 μm. This embodiment enables the flexible shell 4 to have an excellent piercing effect by setting the vibration frequency of the vibration module 8 to 5-15 Hz and the amplitude of the vibration module 8 to 2-8 μm.

[0037] In some preferred embodiments, the vibration module 8 includes a vibration element 81, a signal amplifier 82 and a signal generator 83, the signal generator 83 is connected to the input end of the signal amplifier 82, the output end of the signal amplifier 82 is connected to the vibration element 81, the vibration element 81 is connected to the end of the electrode body 1 away from the signal acquisition end 101, the signal generator 83 is used to output a vibration waveform, the signal amplifier 82 is used to amplify the vibration waveform, and the vibration element 81 is used to generate corresponding vibrations according to the amplified vibration waveform. The vibration waveform of this embodiment can be a sine wave or a square wave, the signal amplifier 82 of this embodiment preferably amplifies the vibration waveform output by the signal generator 83 by 10 times, and the input voltage allowable range of the vibration terminal of this embodiment is preferably -2V~+12V.

[0038] In some preferred embodiments, the electrode tray 3 is made of ABS plastic. The electrode tray 3 of this embodiment is made of ABS plastic. Since ABS plastic has the advantages of excellent mechanical properties and good chemical stability, this embodiment can effectively improve the mechanical properties and chemical stability of the electrode tray 3, thereby effectively improving the mechanical properties and chemical stability of the brain electrode.

[0039] In some preferred embodiments, the end of the flexible housing 4 close to the signal collection end 101 has a puncture portion 10. This embodiment can further reduce the difficulty and puncture force of the flexible housing 4 puncturing brain tissue by providing the puncture portion 10 at the end of the flexible housing 4 close to the signal collection end 101.

[0040] In some preferred embodiments, the ratio of the extension length of the barb structure 6 to the root length of the barb structure 6 is 3:1-5:1. This embodiment enhances the structural strength of the barb structure 6 by setting the ratio of the extension length of the barb structure 6 to the root length of the barb structure 6 to 3:1-5:1, and this embodiment can effectively avoid the situation where the barb structure 6 is easily deformed or broken due to the barb structure 6 being too long and the barb structure 6 has insufficient friction reduction effect due to the barb structure 6 being too short.

[0041] In some preferred embodiments, the frontmost barb structure 6 smoothly transitions with the pricking portion 10. This embodiment can avoid the situation where the insertion of the flexible housing 4 is affected due to the unsmooth transition between the frontmost barb structure 6 and the pricking portion 10 and improve the structural stability of the brain electrode by making the frontmost barb structure 6 and the pricking portion 10 smoothly transition.

[0042] In some preferred embodiments, the barb structure 6 smoothly transitions with the flexible shell 4. This embodiment can further improve the structural strength of the barb structure 6 and the friction reduction effect of the flexible shell 4 by making the barb structure 6 smoothly transition with the flexible shell 4.

[0043] In some preferred embodiments, the number of barb groups is two, and the included angle of the extension surfaces of the two barb groups is 45°-120°. The extension surface of the barb group of this embodiment is the plane where the axis of all barb structures 6 in the same barb group is located. This embodiment can improve the similarity between the flexible shell 4 and the mosquito mouthparts by setting the included angle of the extension surfaces of the two barb groups to 45°-120°, so as to further enhance the friction reduction effect of the flexible shell 4. The opening 5 of this embodiment can be located at the top or bottom of the flexible shell 4. Preferably, the opening 5 of this embodiment is located at the top of the flexible shell 4.

[0044] From the above, it can be seen that the brain electrode provided by the present application can reduce the difference in mechanical properties between the brain electrode and the brain tissue by disposing a flexible shell 4 outside the electrode body 1. Therefore, the present application can effectively solve the problem that the brain tissue is easily damaged when the brain electrode is inserted into the brain due to the large difference in mechanical properties between the brain electrode and the brain tissue.

[0045] In the embodiments provided in the present application, it should be understood that, herein, relational terms such as first and second, etc. are merely used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations.

[0046] The above description is only an embodiment of the present application and is not intended to limit the protection scope of the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A brain electrode, characterized in that The brain electrodes include: The electrode body comprises a signal collection end and a conducting part, wherein one end of the conducting part away from the signal collection end is connected to a signal receiving circuit; An electrode tray, wrapping the side of the conductive part; A flexible shell, which wraps the electrode body and the electrode tray and has an opening for exposing the signal collection end; The electrode tray is used to fix the position of the electrode body in the flexible shell.

2. The brain electrode according to claim 1, characterized in that The cross-section of the flexible shell is circular, and a plurality of barb groups are arranged in a circumferential array on the outer circumference of the flexible shell. Each of the barb groups includes a plurality of barb structures inclined away from the signal collection end.

3. The brain electrode according to claim 2, characterized in that The included angle between the extension direction of the barb structure and the extension direction of the flexible shell is 25°-50°.

4. The brain electrode according to claim 2, characterized in that The ratio of the sum of the root lengths of the barb structures in the same barb group to the length of the flexible shell is greater than 0.

5.

5. The brain electrode according to claim 2, characterized in that: The outer surface of the flexible shell is provided with a micro-nano array structure.

6. The brain electrode according to claim 2, characterized in that: The barbed structure retracts away from the flexible housing.

7. The brain electrode according to claim 1, characterized in that The brain electrode also includes a vibration module, which is connected to an end of the conductive part away from the signal collection end. The vibration module is used to make the flexible shell vibrate periodically through the electrode body when the brain electrode is inserted into brain tissue.

8. The brain electrode according to claim 7, characterized in that The vibration frequency of the vibration module is 5-15 Hz, and the amplitude of the vibration module is 2-8 μm.

9. The brain electrode according to claim 7, characterized in that: The vibration module includes a vibration element, a signal amplifier and a signal generator. The signal generator is connected to the input end of the signal amplifier, the output end of the signal amplifier is connected to the vibration element, the vibration element is connected to an end of the electrode body away from the signal collection end, the signal generator is used to output a vibration waveform, the signal amplifier is used to amplify the vibration waveform, and the vibration element is used to generate corresponding vibration according to the amplified vibration waveform.

10. The brain electrode according to claim 1, characterized in that The electrode tray is made of ABS plastic.

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