ECMO loop blood recovery assembly and ECMO loop blood transfusion system

Abstract

The invention relates to the field of medical instruments, in particular to an ECMO loop blood recovery assembly and an ECMO loop blood transfusion system. The ECMO loop blood recovery assembly comprises a liquid inlet pipeline, a first pump body, a liquid collector, a filtering pipeline, a filter, a liquid outlet pipeline, a filtrate leading-out pipeline and a second pump body; the liquid inlet pipeline, the first pump body, the liquid collector, the filtering pipeline, the filter and the liquid outlet pipeline are communicated in sequence; the filtrate leading-out pipeline is communicated with the filter, the second pump body is arranged on the filtrate leading-out pipeline, and the end, communicated with the filter, of the filtrate leading-out pipeline is provided with an on-off valve; wherein the liquid inlet pipeline is used for being communicated with an ECMO pipeline; the liquid outlet pipeline is used for leading out blood filtered by the liquid collector and the filter; and the filtrate leading-out pipeline is used for leading out the filtrate filtered by the filter. The ECMO loop blood recovery assembly is applied to an ECMO loop blood transfusion system, infection can be avoided, and the probability of thrombus and blood coagulation dysfunction is reduced.

Description

Technical Field

[0001] The present invention relates to the field of medical devices, and in particular to an ECMO loop blood recovery component and an ECMO loop blood transfusion system. Background Art

[0002] Extracorporeal membrane oxygenation (ECMO) is one of the common means of circulatory support for patients. The application of VA ECMO has been increasing in recent years, especially in patients after cardiac surgery and cardiac arrest, and has become the most mainstream means of circulatory support. During ECMO treatment, blood circulates in the extracorporeal circuit. When the ECMO circuit is removed, there is still about 800mL of whole blood in the circuit. Because the extracorporeal circuit is thick, if the blood is directly pumped into the blood vessels using a centrifugal pump, the centrifugal pump may cause volume overload or air to enter the blood vessels due to the fast blood flow rate, causing serious adverse consequences.

[0003] At present, blood transfusion in the ECMO circuit mainly uses a blood recovery device to pump blood into a blood storage bag, and then wash the blood before transfusing the red blood cells into the patient's body. This method is difficult to operate and prone to infection. It is also difficult and takes a long time to vent, and it is easy to fail due to thrombosis. In addition, there is also the problem of being unable to transfuse platelets and plasma, which may cause coagulation dysfunction. Summary of the invention

[0004] The purpose of the present invention includes providing an ECMO loop blood recovery component and an ECMO loop blood transfusion system, which have a simple structure, are easy to operate, can be operated in a sterile area, thereby avoiding infection; and can quickly filter gases and transfuse blood cells and plasma, thereby ensuring the utilization and recovery of blood to the greatest extent.

[0005] The embodiments of the present invention can be implemented as follows: In a first aspect, the present invention provides an ECMO loop blood recovery assembly, the ECMO loop blood recovery assembly comprising a liquid inlet pipeline, a first pump body, a liquid collector, a filter pipeline, a filter, a liquid outlet pipeline, a filtrate outlet pipeline and a second pump body; The liquid inlet pipeline, the first pump body, the liquid collector, the filter pipeline, the filter and the liquid outlet pipeline are connected in sequence; The filtrate outlet pipeline is connected to the filter, the second pump body is arranged on the filtrate outlet pipeline, and an on-off valve is arranged at one end of the filtrate outlet pipeline connected to the filter; Among them, the liquid inlet pipeline is used to connect with the ECMO pipeline; the liquid outlet pipeline is used to export the blood filtered by the liquid collector and the filter; the filtrate export pipeline is used to export the filtrate filtered by the filter.

[0006] In an optional embodiment, the liquid inlet pipeline is configured with a liquid medicine inlet port.

[0007] In an optional embodiment, the liquid collector includes a body and a filter screen, the body is configured with an inner cavity and an exhaust control member communicated with the inner cavity; The filter screen is arranged in the inner cavity, and the inner cavity is communicated with the liquid inlet pipeline and the filter pipeline.

[0008] In an optional embodiment, a first pressure detector is configured at one end of the filtration pipeline close to the filter; a second pressure detector is configured at one end of the liquid outlet pipeline close to the filter; and a third pressure detector is configured at one end of the filtrate outlet pipeline close to the filter.

[0009] In an optional embodiment, the ECMO circuit blood recovery assembly further includes a filtrate collection member connected to the filtrate outlet pipeline.

[0010] In an optional embodiment, the inner diameters of the liquid inlet pipeline, the filtration pipeline and the liquid outlet pipeline are 4-10 mm.

[0011] In an optional embodiment, the volume of the liquid collector is 30-80 ml, and the volume of the filter is 50-150 ml.

[0012] In an optional embodiment, the total volume of the ECMO circuit blood recovery assembly is 400-900 ml.

[0013] In a second aspect, the present invention provides an ECMO loop blood retransfusion system, the ECMO loop blood retransfusion system comprising a blood retransfusion component and the ECMO loop blood recovery assembly described above; The blood return part is communicated with the liquid discharge port of the liquid discharge pipeline.

[0014] In an alternative embodiment, the blood return device includes a sterile blood storage bag or a central venous catheter.

[0015] The ECMO loop blood recovery assembly and ECMO loop blood return system provided by the embodiments of the present invention have the following beneficial effects: The ECMO loop blood recovery component includes an inlet pipeline, a first pump body, a liquid collector, a filter pipeline, a filter, an outlet pipeline, a filtrate outlet pipeline and a second pump body; the inlet pipeline, the first pump body, the liquid collector, the filter pipeline, the filter and the outlet pipeline are connected in sequence; the filtrate outlet pipeline is connected to the filter, the second pump body is arranged on the filtrate outlet pipeline, and an on-off valve is arranged at one end of the filtrate outlet pipeline connected to the filter; wherein, the inlet pipeline is used to be connected to the ECMO pipeline; the outlet pipeline is used to outlet blood filtered by the liquid collector and the filter; the filtrate outlet pipeline is used to outlet filtrate filtered by the filter.

[0016] The ECMO loop blood recovery component is used in the ECMO loop blood transfusion system. It has a simple structure and is easy to operate. It can be operated in a sterile area to avoid infection. It can also quickly filter gas thrombi and transfuse blood cells and plasma, thereby ensuring the utilization and recovery of blood to the greatest extent. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0018] Figure 1 A schematic diagram of the structure of the ECMO loop blood return system provided in this embodiment; Figure 2 A schematic diagram of the structure of the 100-ECMO loop blood recovery assembly provided in this embodiment; Figure 3 A schematic diagram of the use of the ECMO loop blood transfusion system provided in this embodiment.

[0019] Icons: 100-ECMO loop blood recovery component; 110-inlet pipeline; 111-inlet port; 120-first pump body; 130-liquid collector; 140-filter pipeline; 150-filter; 160-outlet pipeline; 161-outlet port; 170-filtrate outlet pipeline; 171-on-off valve; 180-second pump body; 112-medicine liquid inlet port; 131-body; 132-filter; 133-exhaust Control part; 101-first pressure detector; 102-second pressure detector; 103-third pressure detector; 104-filtrate collection part; 200-ECMO loop blood return system; 210-central venous catheter; 211-first pipeline; 212-second pipeline; 300-target object; 400-ECMO pipeline; 410-arterial catheter side port; 420-venous catheter side port; 430-centrifugal pump. DETAILED DESCRIPTION

[0020] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings here can be arranged and designed in various different configurations.

[0021] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0023] In the description of the present invention, it should be noted that if the terms "upper", "lower", "inside", "outside", etc. appear to indicate an orientation or position relationship, they are based on the orientation or position relationship shown in the accompanying drawings, or are the orientation or position relationship in which the product of the invention is usually placed when used. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0024] In addition, the terms “first”, “second”, etc., if used, are merely used to distinguish between the descriptions and should not be understood as indicating or implying relative importance.

[0025] It should be noted that, in the absence of conflict, the features in the embodiments of the present invention may be combined with each other.

[0026] Please refer to Figure 1-Figure 3 , this embodiment provides an ECMO loop blood transfusion system 200, the ECMO loop blood transfusion system 200 includes a blood transfusion component and an ECMO loop blood recovery component 100; The ECMO circuit blood recovery assembly 100 includes a liquid inlet pipeline 110, a first pump body 120, a liquid collector 130, a filter pipeline 140, a filter 150, a liquid outlet pipeline 160, a filtrate outlet pipeline 170 and a second pump body 180; The liquid inlet pipeline 110, the first pump body 120, the liquid collector 130, the filter pipeline 140, the filter 150 and the liquid outlet pipeline 160 are connected in sequence; The filtrate outlet pipeline 170 is connected to the filter 150, the second pump body 180 is arranged on the filtrate outlet pipeline 170, and an on-off valve 171 is arranged at one end of the filtrate outlet pipeline 170 connected to the filter 150; Among them, the liquid inlet pipeline 110 is used to connect with the ECMO pipeline 400; the liquid outlet pipeline 160 is used to export the blood filtered by the liquid collector 130 and the filter 150; the filtrate outlet pipeline 170 is used to export the filtrate filtered by the filter 150.

[0027] The blood return part is connected to the discharge port of the liquid outlet pipeline 160.

[0028] It should be noted that the end of the liquid inlet pipeline 110 that is connected to the ECMO pipeline 400 is the liquid inlet 111, and the end of the liquid outlet pipeline 160 that is used to discharge the blood filtered by the liquid collector 130 and the filter 150 is the liquid outlet 161.

[0029] Please refer to Figure 1-Figure 3 The working principle of the ECMO loop blood return system 200 using the ECMO loop blood recovery assembly 100 is: The ECMO loop blood return system 200 can connect the liquid inlet 111 of the liquid inlet pipeline 110 with the ECMO pipeline 400, and then can introduce the blood in the ECMO pipeline 400 into the liquid inlet pipeline 110 through the first pump body 120, and then pump it into the liquid collector 130, and perform exhaust treatment and primary filtration through the liquid collector 130; The blood after the exhaust treatment and the primary filtration in the liquid collector 130 is introduced into the filter 150. The filter 150 can filter the blood to concentrate the blood and remove excess water. The blood cells and plasma components cannot be filtered, so that the effective components in the blood can be retained. The filtered filtrate can be discharged through the filtrate outlet pipeline 170 under the action of the second pump body 180. The processed blood can retain blood cells and plasma components, and after being processed by the exhaust filtration of the liquid collector 130, it can be led out through the liquid outlet 161 of the liquid outlet pipeline 160 to the blood return infusion device for reuse; It should be noted that, under the action of the first pump body 120 , the blood can flow unidirectionally in the liquid collector 130 , the filter pipeline 140 , the filter 150 and the liquid outlet pipeline 160 after being introduced into the liquid inlet pipeline 110 .

[0030] In summary, from the above content, it can be known that during the use of the ECMO loop blood transfusion system 200, through the setting of the pump body, the blood can flow quickly in the pipeline after being introduced, and then quickly filter and exhaust, while retaining the effective components in the blood, and the overall structure is simple and convenient to operate, and the structure size is small, which can meet the conditions for operation and use in a sterile area. Therefore, its operation and use can avoid infection; and because it is equipped with an exhaust and filtration process, it can quickly filter the gas and reinfuse the blood cells and plasma, thereby ensuring the utilization and recovery of blood to the greatest extent.

[0031] For further information, please refer to Figure 1-Figure 3In this embodiment, when configuring the blood return part, the blood return part may include a sterile blood storage bag or a central venous catheter 210. The sterile blood storage bag can be used to store the filtered blood for subsequent use; and the central venous catheter 210 can return the filtered blood after being connected to the target object 300, thereby improving efficiency.

[0032] It should be noted that the target object 300 can be a simulation model, the purpose of which is to facilitate relevant teaching demonstrations or relevant operation exercises; in addition, when conducting teaching demonstrations or relevant operation exercises, the blood in the full text can also use a substitute fluid in the prior art, and its specific type can be selected according to the teaching purpose or operation requirements, so it will not be repeated here.

[0033] For further information, please refer to Figure 1-Figure 3 In this embodiment, when configuring the inlet pipeline 110, the inlet pipeline 110 is configured with a liquid medicine inlet port 112. That is, during use, on the basis that the inlet pipeline 110 can be connected with the ECMO pipeline 400, relevant liquid medicine can be added to the inlet pipeline 110 through the liquid medicine inlet port 112. In this embodiment, the addition of anticoagulant drugs is used as an example for explanation, and after the anticoagulant drugs are added to the inlet pipeline 110 through the liquid medicine inlet port 112, the flow path of the anticoagulant drugs in the system is the same as the flow path of blood.

[0034] When the liquid collector 130 is configured, its function is to filter and exhaust the liquid at the first stage. Based on this, the liquid collector 130 includes a body 131 and a filter screen 132. The body 131 is provided with an inner cavity and an exhaust control member 133 connected to the inner cavity. The filter screen 132 is placed in the inner cavity, and the inner cavity is connected to the liquid inlet pipeline 110 and the filter pipeline 140. The exhaust control member 133 can be controlled independently to facilitate exhaust. When the body 131 is configured, the opening for communicating with the liquid inlet pipeline 110 is arranged on the side thereof, and the opening for communicating with the filter pipeline 140 is arranged on the bottom thereof, in order to improve the efficiency of liquid inlet and liquid discharge.

[0035] For further information, please refer to Figure 1-Figure 3 In this embodiment, in order to control the flow rate of blood or filtrate in the system, a first pressure detector 101 is disposed at one end of the filtration pipeline 140 close to the filter 150, a second pressure detector 102 is disposed at one end of the liquid outlet pipeline 160 close to the filter 150, and a third pressure detector 103 is disposed at one end of the filtrate outlet pipeline 170 close to the filter 150; Such a setting can adjust the working state of the first pump body 120 and the second pump body 180 based on the pressure data of the filter pipeline 140, the pressure data of the liquid outlet pipeline 160 and the pressure data of the filtrate outlet pipeline 170 detected by the first pressure detector 101, the second pressure detector 102 and the third pressure detector 103, respectively, so as to adjust the outlet speed of the filtrate. It should be noted that the outlet speed of the liquid outlet pipeline 160 can also be adjusted based on the aforementioned pressure data, and it can also be precisely adjusted on the basis of the pump body configured on the liquid outlet pipeline 160; in addition, in order to facilitate the adjustment of the maximum flow of the inlet pipeline 110, the filter pipeline 140, the filtrate outlet pipeline 170 and the liquid outlet pipeline 160, a flow valve can also be set at the interface or port position of the inlet pipeline 110, the filter pipeline 140, the filtrate outlet pipeline 170 and the liquid outlet pipeline 160.

[0036] In order to facilitate the collection of the derived filtrate so as to aseptically process it, the ECMO loop blood recovery component 100 also includes a filtrate collection component 104 connected to the filtrate derivation pipeline 170.

[0037] For further information, please refer to Figure 1-Figure 3 On the basis of the above structure, when configuring the inlet pipeline 110, the filter pipeline 140 and the outlet pipeline 160, the inner diameter of the inlet pipeline 110, the filter pipeline 140 and the outlet pipeline 160 can be set to 4-10mm; in addition, when configuring the liquid collector 130 and the filter 150, since the blood inside needs to be processed, a certain amount of blood or other liquid medicine is temporarily stored therein. Based on this, the volume of the liquid collector 130 can be set to 30-80ml, and the volume of the filter 150 can be set to 50-150ml. In addition, since after the ECMO pipeline 400 is removed, the ECMO pipeline 400 has about 800mL of whole blood, the total volume of the ECMO loop blood recovery component 100 is 400-900ml. It should be noted that, in order to simplify the overall structure of the system, when configuring the various pipelines of the system, the total length of the pipelines of the system can be set within 500 cm, including 500 cm. In addition, since after the ECMO pipeline 400 is removed, the ECMO pipeline 400 has about 800 mL of whole blood, the total volume of the ECMO loop blood recovery component 100 is 400-900 ml.

[0038] Specifically, in the present embodiment, when configuring the liquid inlet pipeline 110, the filter pipeline 140 and the liquid outlet pipeline 160, their inner diameters are set to 8 mm, and when configuring the liquid collector 130 and the filter 150, the volume of the liquid collector 130 is set to 50 ml, and the volume of the filter 150 is set to 100 ml; in addition, when the total length of the system pipeline is set to about 500 cm, the total volume of the system is about 600 ml. The purpose of such a setting is to keep the system in a continuous operation state during use, that is, after the system is exhausted, blood can be continuously introduced, filtered and discharged, so that the total volume of the system can be less than 800 mL of blood remaining in the ECMO pipeline 400.

[0039] From the above content, please refer to Figure 1-Figure 3 The blood return component of the ECMO loop blood return system 200 may include a sterile blood storage bag or a central venous catheter 210. Based on this, the following will take the blood return component as the central venous catheter 210 as an example to specifically describe the workflow of the ECMO loop blood return system 200: After the ECMO loop blood recovery component 100 of the ECMO loop blood return system 200 is docked, the on-off valve 171 is closed to block the filtrate outlet pipeline 170 and the filter 150; then, 1000 ml of balanced salt solution is added to the liquid inlet pipeline 110; then the liquid outlet 161 of the liquid outlet pipeline 160 begins to exhaust gas, and then the ECMO loop blood recovery component 100 is pre-filled to completely remove the gas in the pipeline of the ECMO loop blood recovery component 100; The inlet for adding the balanced salt solution to the inlet pipeline 110 may be the interface of the inlet pipeline 110 for communicating with the ECMO pipeline 400, i.e., the inlet 111, or may be the drug solution introduction port 112; Then, when the ECMO circuit 400 connected to the target object 300 is removed from the machine, the arteriovenous circuit connected to the target object 300 is clamped, the centrifugal pump 430 stops working, and the arterial catheter side port 410 is connected to the liquid inlet port 111 of the liquid inlet circuit 110 of the ECMO loop blood recovery component 100, that is, the liquid inlet circuit 110 is connected to the ECMO circuit 400; and the venous catheter side port 420 is connected to the infusion set for continuous infusion; A sterile bag is connected to the liquid outlet 161 of the liquid outlet pipeline 160; As the system operates, the introduced balanced salt solution will flow along the pipeline toward the liquid outlet pipeline 160 , and then the sterile bag will begin to receive the liquid first discharged from the liquid outlet pipeline 160 ; When the blood in the ECMO circuit 400 enters the blood inlet circuit 110, anticoagulant drugs are added through the drug inlet port 112; When the blood in the ECMO circuit 400 completely enters the ECMO loop blood recovery assembly 100, the liquid inlet 111 of the liquid inlet circuit 110 and the liquid outlet 161 of the liquid outlet circuit 160 are respectively connected to the central venous catheter 210 connected to the target object 300; the central venous catheter 210 is connected to the blood vessel of the target object 300, and the central venous catheter 210 has two lumens, one lumen at the side port is the first pipeline 211, and the other lumen at the tip is the second pipeline 212; further, when the liquid inlet 111 of the liquid inlet circuit 110 and the liquid outlet 161 of the liquid outlet circuit 160 are connected to the central venous catheter 210, the liquid inlet 111 of the liquid inlet circuit 110 is connected to the first pipeline 211 of the central venous catheter 210, and the liquid outlet 161 of the liquid outlet circuit 160 is connected to the second pipeline 212 of the central venous catheter 210; The shut-off valve 171 is opened to connect the filtrate outlet pipeline 170 with the filter 150, and then the filtrate outlet speed is adjusted by adjusting the second pump body 180 according to the condition of the target object 300 and the actual operating state of the system, that is, the pressure data detected by the first pressure detector 101, the second pressure detector 102 and the third pressure detector 103. In addition, in this process, the flow rate can be adjusted by adjusting the opening of the valve body at each pump body or pipeline port; In addition, after filtering out excess water, the blood discharged through the filter 150 is slowly returned to the target object 300 through the liquid outlet pipe 160 and the second pipe 212 .

[0040] It should be noted that, during the reinfusion process, the inlet pipeline 110 is disconnected from the first pipeline 211, and the inlet pipeline 110 is connected to 1000 ml of normal saline, and the speed of the first pump body 120 is adjusted to 50-80 ml / min. After the blood is completely reinfused into the target object 300, the outlet pipeline 160 is disconnected from the second pipeline 212, and the system stops running.

[0041] The above are only specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily conceived by a technician familiar with the technical field within the technical scope disclosed by the present invention should be covered within the protection scope of the present invention.

Claims

1. An ECMO circuit blood recovery assembly, characterized in that: The ECMO loop blood recovery assembly includes a liquid inlet pipeline, a first pump body, a liquid collector, a filter pipeline, a filter, a liquid outlet pipeline, a filtrate outlet pipeline and a second pump body; The liquid inlet pipeline, the first pump body, the liquid collector, the filter pipeline, the filter and the liquid outlet pipeline are connected in sequence; The filtrate outlet pipeline is in communication with the filter, the second pump body is arranged on the filtrate outlet pipeline, and an on-off valve is arranged at one end of the filtrate outlet pipeline in communication with the filter; Among them, the liquid inlet pipeline is used to communicate with the ECMO pipeline; the liquid outlet pipeline is used to export the blood filtered by the liquid collector and the filter; the filtrate export pipeline is used to export the filtrate filtered by the filter.

2. The ECMO circuit blood recovery assembly according to claim 1, characterized in that: The liquid inlet pipeline is provided with a liquid medicine inlet.

3. The ECMO circuit blood recovery assembly according to claim 1, characterized in that: The liquid collector comprises a body and a filter screen, wherein the body is provided with an inner cavity and an exhaust control member communicating with the inner cavity; The filter screen is placed in the inner cavity, and the inner cavity is communicated with the liquid inlet pipeline and the filter pipeline.

4. The ECMO circuit blood recovery assembly according to claim 1, characterized in that: A first pressure detector is arranged at one end of the filtration pipeline close to the filter; a second pressure detector is arranged at one end of the liquid outlet pipeline close to the filter; and a third pressure detector is arranged at one end of the filtrate outlet pipeline close to the filter.

5. The ECMO circuit blood recovery assembly according to claim 1, characterized in that: The ECMO loop blood recovery component also includes a filtrate collection piece connected to the filtrate outlet pipeline.

6. The ECMO circuit blood recovery assembly according to any one of claims 1 to 5, characterized in that: The inner diameters of the liquid inlet pipeline, the filter pipeline and the liquid outlet pipeline are 4-10 mm.

7. The ECMO circuit blood recovery assembly according to claim 6, characterized in that: The volume of the liquid collector is 30-80 ml, and the volume of the filter is 50-150 ml.

8. The ECMO circuit blood recovery assembly according to claim 6, characterized in that: The total volume of the ECMO loop blood recovery component is 400-900ml.

9. An ECMO loop blood transfusion system, characterized in that: The ECMO circuit blood return system comprises a blood return component and an ECMO circuit blood recovery component as described in any one of claims 1 to 8; The blood return component is communicated with the liquid discharge port of the liquid outlet pipeline.

10. The ECMO loop blood transfusion system according to claim 9, characterized in that: The blood return part includes a sterile blood storage bag or a central venous catheter.

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