A dynamic grinding device and control method for pharmaceutical intermediates

Abstract

The present invention discloses a dynamic grinding device and control method for pharmaceutical intermediates, and relates to the technical field of pharmaceutical raw material grinding. In the present invention: the lower grinding surface has a central cone, a blocking raised ring, and ventilation and return air vertical holes, and the upper grinding surface has corresponding grooves. The air guide component includes an annular air guide shell, etc., which has a photoelectric turbidity and temperature sensor inside. The air inlet cooperates with the return air vertical hole, and the bottom has a return air pipeline and related electric control valves. The bottom frame is fixedly installed with a cooling mechanism, and the return air pipeline runs through it, and there is also an air intake pipe and an air supply mechanism, and the two ends of the air supply mechanism are respectively connected to the return air pipeline and the air supply end box. The present invention avoids the extra operations of stopping grinding or increasing the cooling power at irregular intervals in the prior art, thereby ensuring the process efficiency; compared with the method of directly increasing the cooling power, the present invention effectively reduces energy consumption through reasonable airflow recycling and intelligent regulation, and solves the contradiction between the heat dissipation degree and the cooling cost.

Description

Technical Field

[0001] The invention relates to the fields of pharmaceutical intermediate processing technology and grinding technology, and in particular to a pharmaceutical intermediate dynamic grinding device and a control method. Background Art

[0002] In the process of processing and producing pharmaceutical intermediates, a powder grinder is used to grind and crush the pharmaceutical intermediates. The powder grinder usually grinds at high speed, which will generate heat during the grinding process and destroy the medicinal properties of the pharmaceutical intermediates.

[0003] The prior art generally uses a cooling device to set a condenser in the lower mold to cool the lower mold during grinding, or uses a blowing device to directly blow air to cool the upper and lower molds. However, this method will cool the mold and cannot directly cool the powder. When in use, cooling cannot be completely avoided, and a large amount of heat will still remain in the pharmaceutical intermediate powder during grinding.

[0004] The existing treatment methods are to use a cooling device to cool the mold during grinding. During grinding, some methods use irregular grinding stops to cool the powder, but this undoubtedly increases the time consumption of the process and reduces the production efficiency of the process; some methods directly increase the cooling power and force the mold to be cooled at a low temperature, which undoubtedly greatly increases the energy consumption of the process.

[0005] In the face of the above situation, how to effectively solve the contradiction between the heat dissipation of pharmaceutical intermediate powder during grinding and the time-consuming process and cooling cost has become a problem that needs to be solved. Summary of the invention

[0006] In order to solve the above technical problems, the present invention provides a dynamic grinding device and control method for pharmaceutical intermediates, thereby ensuring the grinding process efficiency of pharmaceutical intermediate raw materials, effectively reducing energy consumption, and solving the contradiction between heat dissipation and cooling cost.

[0007] In order to solve the above technical problems, the present invention is achieved through the following technical solutions:

[0008] The present invention provides a dynamic grinding device for pharmaceutical intermediates, including a base frame, a support frame fixedly installed on the upper side of the base frame, a lower grinding disc limitedly installed on the inner periphery of the support frame, and an upper grinding disc located directly above the lower grinding disc. The upper driving component includes a driving motor and a lifting mechanism. The lifting mechanism is used to drive the upper grinding disc to vertically lift and lower, and the driving motor drives the upper grinding disc to rotate. The lower grinding disc includes an upward lower grinding surface, and the upper grinding disc includes a downward upper grinding surface. The lower grinding surface is provided with a central cone and a blocking protrusion ring. The central cone is provided with a ventilation vertical hole that passes through the lower grinding disc. The blocking protrusion ring is evenly provided with a plurality of return air vertical holes that pass through the lower grinding disc. The upper grinding surface is provided with a central cone groove that matches the central cone and an annular groove that matches the blocking protrusion ring.

[0009] An air guide assembly for supporting the lower grinding disc is arranged inside the support frame, and the air guide assembly includes an annular air guide shell, an air guide cavity located inside the annular air guide shell, and multiple air inlets located on the top plate of the annular air guide shell. A photoelectric turbidity sensor and a temperature sensor are arranged inside the annular air guide shell. The photoelectric turbidity sensor is used to detect the turbidity of the gas in the air guide cavity, and the temperature sensor is used to detect the temperature of the gas in the air guide cavity. Among them, the air inlet is connected to the air guide cavity, and the air inlet is aligned with the bottom opening of the return air vertical hole. The bottom of the annular air guide shell is connected to a return air pipeline equipped with a return air electric control valve, and the return air pipeline is connected to an exhaust pipe located on the upstream side of the return air electric control valve, and the exhaust pipe is equipped with an exhaust electric control valve.

[0010] A cooling mechanism is fixedly installed on the chassis, and the return air pipeline runs through the cooling mechanism in a circuitous manner. The cooling mechanism is used to cool the super-temperature airflow in the return air pipeline. The return air pipeline is connected to an air suction pipe located on the downstream side of the cooling mechanism, and the air suction pipe is equipped with an air suction electric control valve. An air supply mechanism is fixedly installed on the chassis, and the air inlet end of the air supply mechanism is connected to the downstream end of the return air pipeline, and the air outlet end of the air supply mechanism is connected to the air supply end box.

[0011] As a preferred technical solution of the grinding device of the present invention: the edge of the lower grinding surface is provided with an outer blocking inclined ring surface located outside the blocking protrusion ring. The edge of the upper grinding surface is provided with an outer matching inclined ring surface matching with the outer blocking inclined ring surface.

[0012] As a preferred technical solution of the grinding device of the present invention: the inner cone wall surface of the central cone groove is evenly provided with a plurality of airflow dispersion notches distributed along its generatrix, so as to evenly disperse the airflow entering the ventilation vertical hole.

[0013] As a preferred technical solution of the grinding device of the present invention: a first rubber gasket is arranged at the air inlet position on the top of the annular air guide shell, which is in compression contact with the bottom side of the lower grinding disc. An external connecting pipe is arranged at the bottom of the annular air guide shell, and the external connecting pipe is connected to the return air pipeline through a flange structure.

[0014] As a preferred technical solution of the grinding device of the present invention: a filter is arranged at the connection position between the air intake pipe and the external opening.

[0015] As a preferred technical solution of the grinding device of the present invention: an inner ring side frame is fixedly installed inside the support frame, and the air guide assembly is installed at the position of the inner ring side frame. An inner center frame is fixedly installed on the upper side of the base frame, and the air supply end box is fixedly installed at the top position of the inner center frame.

[0016] As a preferred technical solution of the grinding device of the present invention: the air supply mechanism outlet end is connected to the air supply pipe, and the air supply end box is connected to the downstream end of the air supply pipe. The air supply end box is provided with an open cavity, the open cavity is connected to the air supply pipe, the open cavity is aligned with the ventilation vertical hole, and the airflow of the open cavity enters the ventilation vertical hole upward. A second rubber gasket is arranged at the upper opening position of the open cavity to be in compression contact with the bottom side of the lower grinding disc.

[0017] The present invention provides a control method for a dynamic grinding device for a pharmaceutical intermediate, comprising the following contents:

[0018] S1. The intermediate raw materials are evenly dispersed on the lower grinding surface, and then the intermediate raw materials are ground using the upper grinding disc.

[0019] S2. The air suction electric control valve opens, the air supply mechanism starts, sucks in the external air flow and injects air into the air supply terminal box and the ventilation vertical hole.

[0020] S3. After the airflow overflows from the upper opening of the ventilation vertical hole, it is evenly diffused to the grinding area along the airflow gap between the central cone and the central cone groove. The airflow takes away the heat generated by the grinding of the raw material and gathers toward the upper opening of the return air vertical hole. The blocking protrusion ring blocks the raw material particles moving with the airflow, and the outer blocking inclined ring surface blocks the raw material particles passing the blocking protrusion ring from the outside.

[0021] S4. The airflow in the vertical air return hole enters the air guide cavity downward, the photoelectric turbidity sensor detects the turbidity parameters caused by the raw material particle components in the airflow, and the temperature sensor detects the temperature parameters of the airflow.

[0022] S5. If the turbidity parameter is within the standard and the temperature parameter is within the standard, the return air electric control valve is closed and the exhaust electric control valve is opened to discharge the air directly from the exhaust pipe. At this time, the air supply mechanism still inhales the air from the suction pipe.

[0023] S6. If the temperature parameter is within the standard, regardless of whether the turbidity parameter is exceeded, close the exhaust electric control valve and the suction electric control valve, open the return air electric control valve, and the air flow in the air guide cavity directly enters the air supply mechanism along the return air pipeline. Because regardless of whether the turbidity parameter is exceeded, the air flow will contain intermediate raw materials. As long as the cooling mechanism is not required for cooling treatment, the air flow will be recirculated to reduce the loss of raw materials in the grinding area.

[0024] S7. If the turbidity parameter exceeds the standard, the temperature parameter exceeds the standard, close the exhaust electric control valve and the intake electric control valve, open the return air electric control valve, start the cooling mechanism, and the air flow in the air guide cavity will enter the air supply mechanism after being cooled by the cooling mechanism along the return air pipeline.

[0025] S8. Repeat the above airflow control steps until the intermediate raw material grinding is completed.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] 1. The present invention injects air into the ventilation vertical holes through the air supply mechanism. The air flow overflows from the ventilation vertical holes and diffuses to the grinding area to take away the heat, which effectively solves the heat dissipation problem of the pharmaceutical intermediate powder during grinding and avoids the destruction of the medicinal properties due to overheating. In addition, the design of the air return vertical holes and air guide components can make the air flow containing the raw material particles reflux, reduce the loss of raw materials in the grinding area, and improve the utilization rate of raw materials.

[0028] 2. The present invention utilizes a photoelectric turbidity sensor and a temperature sensor to detect airflow parameters. Depending on whether the turbidity and temperature exceed the standard, the discharge, reflux or reflux after cooling of the airflow is intelligently controlled by an electric control valve, thereby realizing dynamic airflow regulation and ensuring the heat dissipation effect and raw material recovery during the grinding process.

[0029] 3. The present invention avoids the extra operations such as stopping grinding or increasing cooling power at irregular intervals in the prior art, thereby ensuring process efficiency; compared with the method of directly increasing cooling power, the present invention effectively reduces energy consumption through reasonable airflow recycling and intelligent regulation, and solves the contradiction between heat dissipation and cooling cost. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 It is an overall schematic diagram of the grinding device of the present invention.

[0031] Figure 2 It is a schematic diagram of the coordination of the lower grinding disc and the gas pipeline in the present invention.

[0032] Figure 3 Schematic diagram of the gas pipeline in the present invention.

[0033] Figure 4 Schematic diagram of the gas guide assembly in the present invention.

[0034] Figure 5 Schematic diagram of the lower grinding disc in the present invention.

[0035] Figure 6 Schematic diagram of the upper grinding disc in the present invention.

[0036] Figure 7 for Figure 2 Schematic diagram of the partial enlargement of point A in the middle.

[0037] Among them: 1- bottom frame; 2- support frame, 201- inner ring side frame, 202- inner center frame; 3- lower grinding disc, 301- lower grinding surface, 302- center cone, 303- ventilation vertical hole, 304- blocking raised ring, 305- air return vertical hole, 306- outer blocking inclined ring surface; 4- upper grinding disc, 401- upper grinding surface, 402- center cone groove, 403- air flow dispersion notch, 404- annular groove, 405- outer matching inclined ring surface; 5- air guide assembly, 501- annular air guide shell, 502- air guide cavity, 503-air inlet, 504-first rubber gasket, 505-photoelectric turbidity sensor, 506-temperature sensor, 507-external connecting pipe; 6-upper drive assembly, 601-drive motor, 602-lifting mechanism; 7-air supply mechanism; 8-air supply pipe; 9-air supply end box, 901-opening mouth, 902-second rubber gasket; 10-return air pipeline; 11-exhaust pipe; 12-exhaust electric control valve; 13-return air electric control valve; 14-cooling mechanism; 15-intake pipe; 16-intake electric control valve; 17-filter. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0039] Embodiment 1: The present invention designs a dynamic grinding device for pharmaceutical intermediates, and the main structure configuration is as follows:

[0040] like Figure 1 , Figure 2 , Figure 3 , Chassis 1: As the basic supporting structure of the entire device, it is made of solid metal materials such as steel, with sufficient strength and stability to bear the weight of other components and the forces generated during the grinding process. Its shape is designed as a rectangular frame structure, and rubber pads can be installed at the four corners of the bottom to reduce vibration and noise during operation of the device and prevent sliding on the ground.

[0041] like Figure 1 , Figure 2 , Figure 3 , Support frame 2: fixedly installed on the upper side of the base frame 1, also made of metal, firmly fixed to the base frame 1 by welding or bolting. Its height design must meet the reasonable working spacing requirements between the upper grinding disc 4 and the lower grinding disc 3, and at the same time take into account the convenience of operation and maintenance. The inner ring side frame 201 inside the support frame 2 is annular in structure, providing a precise installation position and stable support for the air guide component 5, ensuring that the air guide component 5 will not be displaced or shaken during operation.

[0042] like Figure 1 , Figure 2 , Figure 5 , Figure 6 , Figure 7 , lower grinding disc 3: limitedly installed on the inner periphery of the support frame 2, the lower grinding surface 301 is made of high-hardness, wear-resistant alloy material to ensure the grinding effect and service life. The central cone 302 is integrally formed with the lower grinding surface 301, and its taper design should match the central cone groove 402 of the upper grinding disc 4 to ensure that the airflow gap between the two is uniform and stable during the grinding process. The ventilation vertical hole 303 runs through the lower grinding disc 3, and its aperture size is designed according to the required air flow rate, and the inner wall is smooth to reduce the airflow resistance. The blocking protrusion ring 304 surrounds the periphery of the central cone 302, with a moderate height, which can effectively block the raw material particles from entering the return air vertical hole 305, and will not affect the normal operation of the grinding area. The return air vertical holes 305 are evenly distributed on the blocking protrusion ring 304, and their number and aperture are determined according to the overall size and working requirements of the grinding device to ensure that the airflow in the grinding area can be discharged in a timely and effective manner. The outer blocking inclined annular surface 306 is located at the edge of the lower grinding surface 301, and cooperates with the outer matching inclined annular surface 405 of the upper grinding surface 401 to form a good blocking slope structure. Even if a small amount of raw material escapes from the blocking protrusion ring 304, it will be blocked again, and the accompanying air flow will enter the return air vertical hole 305 again to prevent the raw material particles from overflowing from the edge of the grinding area.

[0043] like Figure 1 , Figure 2 , Figure 5 , Figure 6 , Upper grinding disc 4: Located directly above the lower grinding disc 3, it realizes rotation and lifting movement through the upper drive assembly 6. The material of the upper grinding surface 401 is the same as that of the lower grinding surface 301, and the depth and taper of the central cone groove 402 are precisely matched with the central cone 302. The airflow dispersion notches 403 are evenly distributed on the inner cone wall of the central cone groove 402, and their shape and size are designed to enable the airflow entering from the ventilation vertical hole 303 to be evenly dispersed to the grinding area. The annular groove 404 cooperates with the blocking protrusion ring 304 of the lower grinding disc 3. The outer matching inclined annular surface 405 cooperates with the outer blocking inclined annular surface 306 of the lower grinding disc 3 to form a complete matching structure.

[0044] like Figure 3 , Figure 4 , Figure 7, air guide component 5: the annular air guide shell 501 is made of metal material and has good air tightness. The air inlet 503 is located on the top plate of the annular air guide shell 501. The number and distribution of the air inlet 503 should be completely aligned with the bottom opening of the return air vertical hole 305 of the lower grinding disc 3 to ensure that the airflow discharged from the return air vertical hole 305 can enter the air guide cavity 502. The first rubber gasket 504 is installed at the air inlet 503. The material is a high temperature resistant and wear-resistant rubber material. Its thickness and elasticity should be able to ensure close extrusion contact with the bottom side of the lower grinding disc 3 to form a good seal to prevent airflow leakage. The photoelectric turbidity sensor 505 and the temperature sensor 506 are installed at appropriate positions in the air guide cavity 502, which can accurately detect the turbidity and temperature parameters in the airflow. The photoelectric turbidity sensor 505 adopts a high-precision optical detection principle and has a high sensitivity to detect the turbidity changes caused by the raw material particle composition. The temperature sensor 506 uses a fast-response, high-precision thermocouple or thermistor sensor to monitor the airflow temperature in real time. The external connecting pipe 507 is located at the bottom of the annular air guide shell 501 and is reliably connected to the return air pipeline 10 through a flange structure to ensure the air tightness and stability of the connection.

[0045] like Figure 1 , upper drive assembly 6: includes a drive motor 601 and a lifting mechanism 602. The drive motor 601 is a three-phase asynchronous motor with suitable power, good speed regulation performance and torque output, connected to the upper grinding disc 4 by belt drive or gear drive, and drives the upper grinding disc 4 to rotate at a stable speed. The lifting mechanism 602 can adopt a screw nut mechanism or a hydraulic lifting device, which can accurately control the vertical lifting movement of the upper grinding disc 4, and realize the gap adjustment between the upper grinding disc 4 and the lower grinding disc 3 to meet different grinding requirements.

[0046] like Figure 1 , Figure 2 , Figure 3 , Air supply mechanism 7: fixedly mounted on the base frame 1, its air inlet end is connected to the downstream end of the return air pipeline 10 through a pipeline, and the connection adopts pipe fittings and seals with good sealing performance. The air supply mechanism 7 can use an air compressor or a blower, and the selection is made according to the required air flow pressure and flow. Its air outlet is connected to the air supply terminal box 9 through the air supply pipe 8, and the air supply pipe 8 is made of pressure-resistant and corrosion-resistant pipes to ensure the stability and safety of the air flow during the transportation process.

[0047] like Figure 1 , Figure 2 , Figure 3, Air supply end box 9: fixedly installed at the top position of the inner center frame 202, its opening cavity 901 is precisely aligned with the air supply pipe 8 and the ventilation vertical hole 303, ensuring that the airflow output by the air supply mechanism 7 can smoothly enter the ventilation vertical hole 303. The shape and size of the opening cavity 901 should be compatible with the ventilation vertical hole 303 to reduce airflow loss. The second rubber gasket 902 is installed at the upper opening position of the opening cavity 901, and is tightly pressed and contacted with the bottom side of the lower grinding disc 3 to form a reliable seal to prevent airflow leakage.

[0048] like Figure 1 , Figure 2 , Figure 3 , Figure 7 , return air pipeline 10, exhaust pipe 11, and air intake pipe 15: the return air pipeline 10 is made of metal pipes, and its diameter is designed according to the air flow and pressure requirements. It runs through the cooling mechanism 14 in a circuitous manner and is in close contact with the heat exchange components of the cooling mechanism 14 to ensure that the air flow can be fully cooled. The exhaust pipe 11 is connected to the return air pipeline 10 and is located on the upstream side of the return air electric control valve 13. Its outlet can lead to the outdoors or be connected to the exhaust gas treatment equipment. The air intake pipe 15 is connected to the external opening, and a filter 17 is installed at the connection position. The filter 17 adopts a high-efficiency air filter, which can effectively filter dust, impurities, etc. in the air to prevent them from entering the interior of the device and affecting the work. The exhaust pipe 11 is installed with the exhaust electric control valve 12, the return air pipeline 10 is installed with the return air electric control valve 13, and the air intake pipe 15 is installed with the air intake electric control valve 16. The exhaust electric control valve 12, the return air electric control valve 13, and the air intake electric control valve 16 are all electromagnetic valves, which have the characteristics of fast response and precise control. They are connected to the photoelectric turbidity sensor 505 and the temperature sensor 506 through an electrical control system, and automatically control the opening and closing of the valve according to the parameters detected by the sensor, thereby achieving precise control of the airflow.

[0049] like Figure 1 , Figure 2 , Figure 3 , Cooling mechanism 14: It is fixedly mounted on the base frame 1 and can be cooled by air or water. The air-cooled cooling mechanism 14 includes a cooling fan and cooling fins. The fan forces convection air to take away the heat of the airflow in the return air duct 10. The water-cooled cooling mechanism 14 includes a cooling water tank, a water pump and a heat exchange coil. The circulating water exchanges heat with the airflow in the return air duct 10 to achieve a cooling effect. The cooling capacity of the cooling mechanism 14 should be designed according to the workload and heat dissipation requirements of the grinding device to ensure that the airflow temperature can be effectively reduced.

[0050] Embodiment 2: The present invention designs a control method for a dynamic grinding device for pharmaceutical intermediates, which specifically includes the following steps:

[0051] 1. Grinding preparation stage

[0052] The pharmaceutical intermediate raw materials are evenly dispersed on the lower grinding surface 301 to ensure that the raw materials are evenly distributed and of moderate thickness. Then the drive motor 601 of the upper drive assembly 6 is started, and the upper grinding disc 4 is adjusted to a suitable initial grinding gap position through the lifting mechanism 602, and the upper grinding disc 4 is started to rotate to prepare for grinding.

[0053] 2. Air flow injection and circulation start-up phase

[0054] Open the air suction electric control valve 16 and start the air supply mechanism 7 at the same time. The outside air enters through the air suction pipe 15, and after the impurities are filtered out by the filter 17, it is pressurized by the air supply mechanism 7, transported to the air supply end box 9 through the air supply pipe 8, and then injected into the grinding area from the ventilation vertical hole 303. After the injected airflow overflows from the upper opening of the ventilation vertical hole 303, it is evenly diffused to the entire grinding area along the airflow gap between the central cone 302 and the central cone groove 402. During the diffusion process, the airflow fully contacts the raw material being ground, takes away the heat generated by the grinding of the raw material, and then the airflow gathers toward the upper opening of the return air vertical hole 305.

[0055] ㈢Airflow parameter detection stage

[0056] The airflow in the vertical return air hole 305 enters the air guide cavity 502 of the air guide assembly 5 downward. At this time, the photoelectric turbidity sensor 505 installed in the air guide cavity 502 detects the turbidity parameters caused by the raw material particle components in the airflow in real time, and the temperature sensor 506 detects the airflow temperature parameters at the same time. The photoelectric turbidity sensor 505 converts the detected turbidity signal into an electrical signal, and the temperature sensor 506 converts the temperature signal into an electrical signal, and transmits these signals to the electrical control system.

[0057] ㈣ Airflow control stage

[0058] The electrical control system makes judgments and decisions based on the received turbidity and temperature parameter signals.

[0059] If the turbidity parameter is within the standard and the temperature parameter is beyond the standard, it means that the raw material particle content in the air flow is within the acceptable range, but the temperature is too high. At this time, the electrical control system issues a command to close the return air electric control valve 13 and open the exhaust electric control valve 12, so that the air flow in the air guide cavity 502 is directly discharged from the exhaust pipe 11 to reduce the temperature of the grinding area. At the same time, the air supply mechanism 7 continues to inhale the external air flow from the suction pipe 15 to maintain the air flow circulation in the grinding area.

[0060] If the temperature parameter is within the standard, it means that the air flow temperature is within the normal range. Regardless of whether the turbidity parameter is within the standard, the exhaust electric control valve 12 and the suction electric control valve 16 are closed, and the return air electric control valve 13 is opened. The air flow in the air guide cavity 502 directly enters the air supply mechanism 7 along the return air pipeline 10, so as to realize the recycling of the air flow and reduce the loss of raw materials. Because even if the turbidity parameter is within the standard, the raw material particles contained in the air flow may still be recycled in the subsequent circulation process without being discharged immediately.

[0061] If both the turbidity parameter and the temperature parameter exceed the standard, it indicates that the raw material particle content in the airflow is too high and the temperature is too high. At this time, the electrical control system closes the exhaust electric control valve 12 and the suction electric control valve 16, opens the return air electric control valve 13, and starts the cooling mechanism 14. The airflow in the air guide cavity 502 is cooled by the cooling mechanism 14 along the return air pipeline 10, and then enters the air supply mechanism 7 for circulation, which not only reduces the airflow temperature, but also recovers the raw material particles.

[0062] ㈤ Repeated adjustment and grinding end stage

[0063] The above-mentioned airflow detection and control steps are continuously repeated, and the flow direction and state of the airflow are continuously adjusted according to the airflow parameters during the entire grinding process. As the grinding proceeds, the raw material is gradually ground into the required particle size. When the predetermined grinding time is reached or the particle size detection device determines that the raw material has been ground to a qualified particle size, the rotation of the upper grinding disc 4 is stopped, the air supply mechanism 7 and the related electric control valves are closed, and the grinding process of the pharmaceutical intermediate raw material is completed.

[0064] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A dynamic grinding device for pharmaceutical intermediates, comprising a base frame (1), a support frame (2) fixedly mounted on the upper side of the base frame (1), a lower grinding disc (3) limitedly mounted on the inner periphery of the support frame (2), and an upper grinding disc (4) located directly above the lower grinding disc (3), wherein the lower grinding disc (3) comprises an upwardly facing lower grinding surface (301), and the upper grinding disc (4) comprises a downwardly facing upper grinding surface (401), characterized in that: The lower grinding surface (301) is provided with a central cone (302) and a blocking raised ring (304); the central cone (302) is provided with a ventilation vertical hole (303) penetrating the lower grinding disc (3); the blocking raised ring (304) is evenly provided with a plurality of return air vertical holes (305) penetrating the lower grinding disc (3); the upper grinding surface (401) is provided with a central cone groove (402) matching with the central cone (302) and an annular groove (404) matching with the blocking raised ring (304); An air guide assembly (5) for supporting the lower grinding disc (3) is arranged inside the support frame (2), the air guide assembly (5) comprising an annular air guide shell (501), an air guide cavity (502) located inside the annular air guide shell (501), and a plurality of air inlets (503) located on the top plate of the annular air guide shell (501), a photoelectric turbidity sensor (505) and a temperature sensor (506) are arranged inside the annular air guide shell (501), wherein the air inlet (503) is communicated with the air guide cavity (502), and the air inlet (503) is aligned with the bottom opening of the air return vertical hole (305); The bottom of the annular air guide housing (501) is connected to an air return pipeline (10) equipped with an air return electric control valve (13); the air return pipeline (10) is connected to an exhaust pipe (11) located upstream of the air return electric control valve (13); the exhaust pipe (11) is equipped with an exhaust electric control valve (12); The base frame (1) is fixedly mounted with a cooling mechanism (14); the air return pipeline (10) meanders through the cooling mechanism (14); the air return pipeline (10) is connected to an air intake pipe (15) located at a downstream side of the cooling mechanism (14); the air intake pipe (15) is provided with an air intake electric control valve (16); An air supply mechanism (7) is fixedly mounted on the base frame, an air inlet end of the air supply mechanism (7) is connected to a downstream end of an air return pipeline (10), and an air outlet end of the air supply mechanism (7) is connected to an air supply end box (9).

2. The dynamic grinding device for pharmaceutical intermediates according to claim 1, characterized in that: The edge of the lower grinding surface (301) is provided with an outer blocking inclined ring surface (306) located at the periphery of the blocking protruding ring (304); An outer matching inclined annular surface (405) matching with the outer blocking inclined annular surface (306) is provided on the edge of the upper grinding surface (401).

3. The dynamic grinding device for pharmaceutical intermediates according to claim 1, characterized in that: The inner conical wall surface of the central conical groove (402) is evenly provided with a plurality of airflow dispersion notches (403) distributed along its generatrix.

4. The dynamic grinding device for pharmaceutical intermediates according to claim 1, characterized in that: A first rubber gasket (504) is arranged at the air inlet (503) on the top of the annular air guide housing (501) and is in compression contact with the bottom side of the lower grinding disc (3); An external connecting pipe (507) is provided at the bottom of the annular air guide housing (501), and the external connecting pipe (507) is connected to the air return pipeline (10) via a flange structure.

5. The dynamic grinding device for pharmaceutical intermediates according to claim 1, characterized in that: A filter (17) is arranged at the connection position between the air intake pipe (15) and the external opening.

6. The dynamic grinding device for pharmaceutical intermediates according to claim 1, characterized in that: An inner enclosure ring side frame (201) is fixedly mounted on the inner side of the support frame (2), and the air guide assembly is cooperatively mounted at the position of the inner enclosure ring side frame (201); An inner center frame (202) is fixedly mounted on the upper side of the base frame (1), and the air supply end box (9) is fixedly mounted at the top end of the inner center frame (202).

7. The dynamic grinding device for pharmaceutical intermediates according to claim 1, characterized in that: The air outlet end of the air supply mechanism (7) is connected to an air supply pipe (8), and the air supply end box (9) is connected to the downstream end of the air supply pipe (8); The air supply end box (9) is provided with an open cavity (901), the open cavity (901) is in communication with the air supply pipe (8), and the open cavity (901) is aligned with the ventilation vertical hole (303); A second rubber gasket (902) is arranged at the upper opening position of the opening cavity (901) and is in compression contact with the bottom side of the lower grinding disc (3).

8. A control method for a dynamic grinding device for pharmaceutical intermediates, characterized in that: A dynamic grinding device for pharmaceutical intermediates according to any one of claims 1 to 7, comprising the following contents: S1. The intermediate raw material is evenly dispersed on the lower grinding surface (301), and then the intermediate raw material is ground using the upper grinding disc (4); S2. The air suction electric control valve (16) is opened, the air supply mechanism (7) is started, the external air flow is sucked in and the air flow is injected into the air supply terminal box (9) and the ventilation vertical hole (303); S3. After the airflow overflows from the upper opening of the ventilation vertical hole (303), it is evenly diffused to the grinding area along the airflow gap between the central cone (302) and the central cone groove (402), and gathers toward the upper opening of the return air vertical hole (305); S4. The airflow in the return air vertical hole (305) enters the air guide cavity (502) downward, the photoelectric turbidity sensor (505) detects the turbidity parameters caused by the raw material particle components in the airflow, and the temperature sensor (506) detects the airflow temperature parameters; S5. If the turbidity parameter does not exceed the standard and the temperature parameter exceeds the standard, close the return air electric control valve (13), open the exhaust electric control valve (12), and discharge the air directly from the exhaust pipe (11); S6. If the temperature parameter is within the standard, regardless of whether the turbidity parameter is within the standard, the exhaust electric control valve (12) and the intake electric control valve (16) are closed, and the return air electric control valve (13) is opened, so that the air flow in the air guide cavity (502) directly enters the air supply mechanism (7) along the return air pipeline (10); S7. If the turbidity parameter exceeds the standard and the temperature parameter exceeds the standard, the exhaust electric control valve (12) and the intake electric control valve (16) are closed, the return air electric control valve (13) is opened, and the cooling mechanism (14) is started. The airflow in the air guide cavity (502) flows along the return air pipeline (10) and is cooled by the cooling mechanism (14) before entering the air supply mechanism (7); S8. Repeat the above airflow control steps until the intermediate raw material grinding is completed.

Images