Operation evaluation system suitable for glaucoma

Abstract

The embodiment of the invention discloses an operation evaluation system suitable for glaucoma. According to one specific embodiment, the system comprises a scanning device, a storage server, a main control chip and a display device, and the scanning device is used for scanning the eye structure of a user; the main control chip is configured to receive an eye image of a user and generate a three-dimensional eye model with a drainage valve; the main control chip is configured to obtain an initial aqueous humor flow finite element model, aqueous humor attribute information and aqueous humor inlet condition information from the storage server; the main control chip is configured to generate a finite element model to be solved according to the aqueous humor attribute information, the aqueous humor inlet condition information and the initial aqueous humor flow finite element model; the main control chip is configured to solve the finite element model to be solved; the main control chip is configured to generate operation evaluation information according to the simulation result information; and the main control chip is configured to control the display equipment to display the operation evaluation information. According to the embodiment, the safety of glaucoma treatment operation can be improved.

Description

Technical Field

[0001] Embodiments of the present disclosure relate to the technical field of glaucoma, and in particular to a surgical evaluation system suitable for glaucoma. Background Art

[0002] Intraocular pressure is the only modifiable factor in glaucoma treatment, and the study of simulating aqueous humor flow is of great significance for balancing intraocular pressure. At present, the surgical evaluation system can simulate the outflow pathway of aqueous humor (including trabecular meshwork and collecting duct) through a three-dimensional model, but it does not take into account the effect of aqueous humor production on aqueous humor flow. As a result, when evaluating the effects of surgical interventions and related complications on intraocular pressure, the accuracy of the surgical effect evaluated by the surgical evaluation system is low, resulting in low safety of glaucoma treatment surgery.

[0003] The above information disclosed in this Background section is only for enhancement of understanding of the background of the present disclosure concept and therefore it may contain information that does not form the prior art that is already known in this country to a person of ordinary skill in the art. Summary of the invention

[0004] The content of this disclosure is used to introduce concepts in a brief form, which will be described in detail in the detailed implementation section below. The content of this disclosure is not intended to identify the key features or essential features of the technical solution claimed for protection, nor is it intended to limit the scope of the technical solution claimed for protection.

[0005] Some embodiments of the present disclosure provide a surgical evaluation system suitable for glaucoma to solve the technical problems mentioned in the above background technology section.

[0006] Some embodiments of the present disclosure provide a surgical evaluation system suitable for glaucoma, the system comprising: a scanning device, a storage server, a main control chip and a display device, wherein the scanning device is used to scan the user's eye structure, obtain the user's eye image, and send the user's eye image to the main control chip; the main control chip is configured to receive the user's eye image sent by the scanning device, and generate a three-dimensional eye model with a drainage valve according to the user's eye image; the main control chip is configured to obtain an initial aqueous humor flow finite element model, aqueous humor property information and aqueous humor inlet condition information from the storage server, wherein the initial aqueous humor The flow finite element model characterizes the nonlinear relationship among the aqueous humor outlet pressure, the aqueous humor outflow volume and the aqueous humor outflow rate; the main control chip is configured to generate a finite element model to be solved according to the aqueous humor property information, the aqueous humor inlet condition information and the initial aqueous humor flow finite element model; the main control chip is configured to perform aqueous humor flow simulation operations on the three-dimensional eye model with a drainage valve, and to solve the finite element model to be solved to obtain simulation result information; the main control chip is configured to generate surgical evaluation information according to the simulation result information; the main control chip is configured to control the display device to display the surgical evaluation information.

[0007] Optionally, the surgical evaluation system further comprises an input device, the input device is used to detect the input operation of the user acting on the display device, and send the input operation information corresponding to the detected input operation to the main control chip, the main control chip is further configured to: perform three-dimensional model construction processing on the user's eye image to obtain a three-dimensional eye model, and control the display device to display the three-dimensional eye model on a finite element simulation interface, wherein the finite element simulation interface further comprises each glaucoma-related parameter input box and a parameter confirmation control corresponding to each glaucoma-related parameter identifier, and the glaucoma in each glaucoma-related parameter input box The associated parameter input box is used for the user to input glaucoma associated parameter information; in response to receiving the input operation information sent by the above-mentioned input device, and determining that the received input operation information represents the above-mentioned input operation as an operation acting on the above-mentioned parameter confirmation control, each glaucoma associated parameter information corresponding to the above-mentioned each glaucoma associated parameter input box is obtained from the above-mentioned storage server, and the above-mentioned each glaucoma associated parameter information is determined as a glaucoma associated parameter information group; according to the above-mentioned glaucoma associated parameter information group, the above-mentioned three-dimensional eye model is updated to obtain a glaucoma three-dimensional model; according to the above-mentioned three-dimensional glaucoma model, a three-dimensional eye model with a drainage valve is generated.

[0008] Optionally, the main control chip is further configured to: control the display device to display the glaucoma three-dimensional model on the finite element simulation interface, wherein the finite element simulation interface also includes a drainage valve implantation control and an implantation completion control; in response to receiving input operation information sent by the input device, and determining that the received input operation information represents that the input operation is an operation acting on the drainage valve implantation control, control the display device to display the glaucoma three-dimensional model in a three-dimensional modeling module, wherein the three-dimensional modeling module is displayed in the finite element simulation interface; in response to receiving input operation information sent by the input device, and Determine that the received input operation information represents that the input operation is an operation acting on the above-mentioned glaucoma three-dimensional model, update the above-mentioned glaucoma three-dimensional model according to the received input operation information to obtain an updated glaucoma three-dimensional model, and control the above-mentioned display device to display the updated glaucoma three-dimensional model as the glaucoma three-dimensional model in the three-dimensional modeling module; in response to receiving the input operation information sent by the above-mentioned input device, and determining that the received input operation information represents that the input operation is an operation acting on the above-mentioned implant completion control, determine the updated glaucoma three-dimensional model currently displayed in the three-dimensional modeling module as a three-dimensional eye model with a drainage valve.

[0009] Optionally, the finite element simulation interface further includes an aqueous humor outlet pressure input box and an outlet pressure confirmation control, wherein the aqueous humor outlet pressure input box is used for a user to input the aqueous humor outlet pressure, and the main control chip is further configured to: in response to receiving input operation information sent by the input device, and determining that the received input operation information represents that the input operation is an operation acting on the outlet pressure confirmation control, obtain the aqueous humor outlet pressure corresponding to the aqueous humor outlet pressure input box from the storage server, and determine the aqueous humor outlet pressure as the initial aqueous humor outlet pressure information; perform an aqueous humor flow simulation operation on the three-dimensional eye model with a drainage valve according to the initial aqueous humor outlet pressure information, and solve the finite element model to be solved to obtain simulation result information.

[0010] Optionally, the main control chip is further configured to: obtain the eyeball radius and initial resistance coefficient model corresponding to the three-dimensional eye structure with drainage valve from the storage server; input the eyeball radius into the initial resistance coefficient model to obtain the resistance coefficient model to be solved; solve the finite element model to be solved and the resistance coefficient model to be solved to obtain simulation result information.

[0011] Optionally, the aqueous humor property information includes aqueous humor density, and the main control chip is further configured to: generate aqueous humor gravity information according to the aqueous humor density; and generate a finite element model to be solved according to the aqueous humor gravity information, the aqueous humor property information, the aqueous humor inlet condition information and the initial aqueous humor flow finite element model.

[0012] Optionally, the main control chip is also configured to send the surgical evaluation information to the storage server; the storage server is configured to receive the surgical evaluation information sent by the main control chip, and add the surgical evaluation information as historical surgical evaluation information to a historical surgical evaluation information set.

[0013] The above-mentioned embodiments of the present disclosure have the following beneficial effects: through the surgical evaluation system applicable to glaucoma of some embodiments of the present disclosure, the safety of glaucoma treatment surgery can be improved. Specifically, the reason for the low safety of glaucoma treatment surgery is that the surgical evaluation system can simulate the aqueous humor outflow pathway (including trabecular meshwork and collecting duct) through a three-dimensional model, but does not take into account the influence of the production of aqueous humor on the flow of aqueous humor, resulting in the evaluation of the surgical effect evaluated by the surgical evaluation system when evaluating the influence of surgical interventions and related complications on intraocular pressure. The accuracy is low, resulting in the low safety of glaucoma treatment surgery. Based on this, the surgical evaluation system applicable to glaucoma of some embodiments of the present disclosure includes: a scanning device, a storage server, a main control chip and a display device, wherein the scanning device is used to scan the user's eye structure, obtain the user's eye image, and send the user's eye image to the main control chip. Thus, the user's eye image can be obtained, thereby improving the accuracy of the simulation. Secondly, the main control chip is configured to receive the user's eye image sent by the scanning device, and generate a three-dimensional eye model with a drainage valve according to the user's eye image. Thus, a three-dimensional structural model of the user's eye after simulating the drainage valve implantation surgery can be obtained, which can be used to simulate the aqueous humor dynamics after the drainage valve implantation surgery, and then the surgical effect of the corresponding drainage valve implantation surgery can be determined. Afterwards, the above-mentioned main control chip is configured to obtain the initial aqueous humor flow finite element model, aqueous humor property information and aqueous humor inlet condition information from the above-mentioned storage server. Among them, the above-mentioned initial aqueous humor flow finite element model represents the nonlinear relationship between the aqueous humor outlet pressure, the aqueous humor outflow and the aqueous humor outflow rate. Thus, the relationship between the aqueous humor outlet pressure and the aqueous humor outflow and the aqueous humor outflow rate can be established, which can be used to simulate the aqueous humor flow. Next, the above-mentioned main control chip is configured to generate a finite element model to be solved according to the above-mentioned aqueous humor property information, the above-mentioned aqueous humor inlet condition information and the above-mentioned initial aqueous humor flow finite element model; the above-mentioned main control chip is configured to perform aqueous humor flow simulation operations on the above-mentioned three-dimensional eye model with drainage valve, and solve the above-mentioned finite element model to be solved to obtain simulation result information. Thus, the flow of aqueous humor after the drainage valve is implanted can be obtained by simulating the dynamics of aqueous humor. Finally, the main control chip is configured to generate surgical evaluation information according to the simulation result information; the main control chip is configured to control the display device to display the surgical evaluation information. Thus, the surgical effect of the drainage valve implantation surgery can be judged by the simulation results. Also, during the simulation process, the surgical evaluation system establishes the relationship between the aqueous humor outlet pressure and the aqueous humor outflow volume and the aqueous humor outflow rate, and takes into account the influence of the production of aqueous humor on the dynamics of aqueous humor, thereby improving the accuracy of the simulation result information, thereby improving the accuracy of the evaluated surgical effect, and further improving the safety of glaucoma treatment surgery. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] The above and other features, advantages and aspects of the embodiments of the present disclosure will become more apparent with reference to the following detailed description in conjunction with the accompanying drawings. Throughout the accompanying drawings, the same or similar reference numerals represent the same or similar elements. It should be understood that the drawings are schematic and that components and elements are not necessarily drawn to scale.

[0015] Figure 1 is a schematic diagram of the system structure of some embodiments of the surgical evaluation system applicable to glaucoma according to the present disclosure;

[0016] Figure 2 is a communication interaction diagram of some embodiments of a surgical evaluation system applicable to glaucoma according to the present disclosure;

[0017] Figure 3 is an internal test image of a glaucoma three-dimensional model generated by a surgical evaluation system applicable to glaucoma according to some embodiments of the present disclosure;

[0018] Figure 4 is an internal test diagram of aqueous humor flow simulated by a surgical evaluation system for glaucoma according to some embodiments of the present disclosure;

[0019] Figure 5 It is an internal test comparison diagram of a surgical evaluation system for glaucoma according to some embodiments of the present disclosure, which simulates different chamber angle closure angles to verify the effect of drainage valve implantation surgery;

[0020] Figure 6 It is an internal test linear comparison diagram of a surgical evaluation system for glaucoma according to some embodiments of the present disclosure, which simulates different chamber angle closure angles to verify the effect of drainage valve implantation surgery;

[0021] Figure 7 This is an internal test linear comparison diagram of a surgical evaluation system for glaucoma according to some embodiments of the present disclosure, which simulates different chamber angle closure angles to explore the changes in aqueous humor flow rate caused by different drainage valve implantation surgical schemes. DETAILED DESCRIPTION

[0022] Embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although certain embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be construed as being limited to the embodiments set forth herein. On the contrary, these embodiments are provided to provide a more thorough and complete understanding of the present disclosure. It should be understood that the drawings and embodiments of the present disclosure are only for exemplary purposes and are not intended to limit the scope of protection of the present disclosure.

[0023] It should also be noted that, for ease of description, only the parts related to the invention are shown in the drawings. In the absence of conflict, the embodiments and features in the embodiments of the present disclosure can be combined with each other.

[0024] It should be noted that the concepts such as "first" and "second" mentioned in the present disclosure are only used to distinguish different devices, modules or units, and are not used to limit the order or interdependence of the functions performed by these devices, modules or units.

[0025] It should be noted that the modifications of "one" and "plurality" mentioned in the present disclosure are illustrative rather than restrictive, and those skilled in the art should understand that unless otherwise clearly indicated in the context, it should be understood as "one or more".

[0026] The names of the messages or information exchanged between multiple devices in the embodiments of the present disclosure are only used for illustrative purposes and are not used to limit the scope of these messages or information.

[0027] The present disclosure will be described in detail below with reference to the accompanying drawings and in conjunction with embodiments.

[0028] Figure 1 A schematic diagram of the system structure of some embodiments of a surgical evaluation system suitable for glaucoma according to the present disclosure is shown.

[0029] In some embodiments, the surgical evaluation system may include: a scanning device 1, a storage server 2, a main control chip 3 and a display device 4. The scanning device 1 may be a device for scanning the eye structure of a user. For example, the scanning device 1 may be an optical coherence tomography scanner. The storage server 2 may be a server for storage. The main control chip 3 may be a microcontroller. The display device 4 may be a display screen. It should be noted that the display screen 4 may be a touch screen. The main control chip 3 may be connected to the scanning device 1, the storage server 2 and the display device 4 in a communication manner. The communication connection may be a wired connection or a wireless connection. It should be noted that the wireless connection may include but is not limited to 3G / 4G connection, WiFi connection, Bluetooth connection, WiMAX connection, Zigbee connection, UWB (ultrawideband) connection, and other wireless connection methods known now or developed in the future. In practice, the scanning device 1 may be used to scan the eye structure of a user, obtain an eye image of the user, and send the eye image of the user to the main control chip 3. The eye image of the user may represent the structure of the eye of the user.

[0030] In some embodiments, the main control chip 3 may be configured to receive the user's eye image sent by the scanning device 1, and generate a three-dimensional eye model with a drainage valve according to the user's eye image. The three-dimensional eye model with a drainage valve may be a three-dimensional structure model of the user's eye with a drainage valve added to the user's eye structure. The drainage valve may be a drainage valve for treating glaucoma.

[0031] Optionally, the surgical evaluation system may further include an input device. The input device may be a device for a simulated user to interact with the display device 4. The input device may include a mouse and a keyboard. The simulated user may be a user who needs to perform a glaucoma surgery simulation. The input device may be used to detect the input operation of the user on the display device 4, and send the input operation information corresponding to the detected input operation to the main control chip 3. The input operation may include but is not limited to at least one of the following: text input operation, click, slide, hover. The input operation information may include but is not limited to the input operation position and the input operation type. The input operation position may be the position on the display device 4 where the input operation is used. The input operation position may be the coordinates of the input operation on the display device 4.

[0032] Optionally, the main control chip 3 may be further configured as follows:

[0033] The first step is to perform a three-dimensional model construction process on the above-mentioned user's eye image to obtain an eye three-dimensional model, and control the above-mentioned display device 4 to display the above-mentioned eye three-dimensional model in a finite element simulation interface. Among them, the above-mentioned finite element simulation interface can be an interface for performing finite element simulation software. For example, the above-mentioned finite element simulation software can be COMSOL Multiphysics software. The above-mentioned finite element simulation interface can also include each glaucoma-related parameter input box and a parameter confirmation control corresponding to each glaucoma-related parameter identifier. The glaucoma-related parameter identifier can be a unique identifier of the glaucoma-related parameter. The glaucoma-related parameter can be a parameter associated with glaucoma. Each glaucoma-related parameter identifier can include but is not limited to a closed angle angle and a trabecular meshwork width. The above-mentioned closed angle angle can be an angle of angle closure. The above-mentioned trabecular meshwork width can be the width of the trabecular meshwork. The glaucoma-related parameter identifiers in each glaucoma-related parameter identifier can correspond one-to-one to the glaucoma-related parameter input boxes in each glaucoma-related parameter input box. The glaucoma-associated parameter input boxes in the above-mentioned glaucoma-associated parameter input boxes can be used for the user to input the glaucoma-associated parameter information corresponding to the glaucoma-associated parameter identifier. The glaucoma-associated parameter information may include but is not limited to the glaucoma-associated parameter value. The glaucoma-associated parameter value may be a numerical value corresponding to the glaucoma-associated parameter identifier. The above-mentioned parameter confirmation control may be a control for the user to confirm each glaucoma-associated parameter information. In practice, first, the user's eye two-dimensional model can be constructed according to the above-mentioned user's eye image through the preset model construction software. Among them, the above-mentioned preset model construction software can be a software that constructs a two-dimensional model or a three-dimensional model through an image. For example, the above-mentioned preset model construction software can be SOLIDWORKS software. The above-mentioned user eye two-dimensional model can be a model of the plane structure of the eye of the above-mentioned target user. Then, the above-mentioned user eye two-dimensional model can be input into the above-mentioned finite element simulation software for three-dimensional conversion processing to obtain the eye three-dimensional model, and control the above-mentioned display device 4 to display the above-mentioned eye three-dimensional model in the finite element simulation interface. It should be noted that the eye three-dimensional model corresponds to the eye model information. The above-mentioned eye model information can characterize the eye three-dimensional model. The above-mentioned eye model information may include but is not limited to an eye structure information set corresponding to each eye structure identifier of the three-dimensional eye model. The eye structure identifiers in the above-mentioned each eye structure identifier may correspond one to one with the eye structure information in the above-mentioned eye structure information set. The eye structure identifier may be a unique identifier of the eye structure. The above-mentioned each eye structure identifier may include but is not limited to the posterior chamber ciliary process, trabecular meshwork, chamber angle, scleral process and iris. The eye structure information may include but is not limited to a structure parameter set of each parameter type. The above-mentioned parameter types may include but are not limited to size and position. The structure parameters may be parameters of the corresponding parameter types.

[0034] The second step, in response to receiving the input operation information sent by the above-mentioned input device, and determining that the received input operation information represents the above-mentioned input operation as an operation acting on the above-mentioned parameter confirmation control, obtains each glaucoma-related parameter information corresponding to the above-mentioned each glaucoma-related parameter input box from the above-mentioned storage server 2, and determines the above-mentioned each glaucoma-related parameter information as a glaucoma-related parameter information group.

[0035] The third step is to update the above three-dimensional eye model according to the above glaucoma-related parameter information group to obtain a glaucoma three-dimensional model. Figure 3 As shown, the above-mentioned glaucoma three-dimensional model can be a three-dimensional eye model that characterizes an eye as glaucoma. In practice, the structural parameters corresponding to the above-mentioned glaucoma-related parameter information in the above-mentioned eye structure information set can be updated to the above-mentioned glaucoma-related parameter information, and according to the above-mentioned glaucoma-related parameter information, the above-mentioned eye three-dimensional model is updated by the above-mentioned finite element software to obtain the glaucoma three-dimensional model. Among them, the above-mentioned parameters corresponding to the above-mentioned glaucoma-related parameter information can be: the corresponding eye structure identifier is the same as the structural parameter of the eye structure identifier corresponding to the glaucoma-related parameter information.

[0036] The fourth step is to generate a three-dimensional eye model with a drainage valve based on the above three-dimensional glaucoma model.

[0037] Therefore, a three-dimensional glaucoma model with different glaucoma angle closure angles can be constructed through the surgical evaluation system, thereby simulating the aqueous humor flow of different glaucoma types.

[0038] Optionally, the main control chip 3 may be further configured as follows:

[0039] Step 1, control the display device 4 to display the glaucoma three-dimensional model on the finite element simulation interface. The finite element simulation interface may further include a drainage valve implantation control and an implantation completion control. The drainage valve implantation control may be a control for a user to implant a drainage valve to simulate a drainage valve implantation operation. The implantation completion control may be a control for a user to confirm whether the drainage valve structure has been implanted. The drainage valve structure may be a structure of a drainage valve for treating glaucoma.

[0040] Step 2, in response to receiving the input operation information sent by the above-mentioned input device, and determining that the received input operation information represents that the above-mentioned input operation is an operation acting on the above-mentioned drainage valve implant control, control the above-mentioned display device 4 to display the above-mentioned glaucoma three-dimensional model in the three-dimensional modeling module. Among them, the above-mentioned three-dimensional modeling module can be a module for constructing a three-dimensional model. The above-mentioned three-dimensional modeling module can include but is not limited to various modeling controls corresponding to various modeling tool types. The modeling tool type can be but is not limited to one of the following: line segment, curve, rectangle, mirror. The modeling control can be a control for the user to select the corresponding modeling tool type. The above-mentioned three-dimensional modeling module can be displayed in the above-mentioned finite element simulation interface.

[0041] Step 3: in response to receiving the input operation information sent by the input device, and determining that the received input operation information indicates that the input operation is an operation acting on the glaucoma three-dimensional model, the glaucoma three-dimensional model is updated according to the received input operation information to obtain an updated glaucoma three-dimensional model, and the display device 4 is controlled to display the updated glaucoma three-dimensional model in the three-dimensional modeling module as the glaucoma three-dimensional model. In practice, the finite element simulation software can be used to update the glaucoma three-dimensional model according to the received input operation information to obtain an updated glaucoma three-dimensional model.

[0042] Step 4, in response to receiving the input operation information sent by the above-mentioned input device, and determining that the received input operation information represents the above-mentioned input operation as an operation acting on the above-mentioned implant completion control, the updated glaucoma three-dimensional model currently displayed in the three-dimensional modeling module is determined to be a three-dimensional eye model with a drainage valve.

[0043] Therefore, the simulation user can freely set the drainage valve implantation plan through the surgical evaluation system, thereby simulating the impact of different drainage valve implantation surgeries on the flow of aqueous humor.

[0044] In some embodiments, the main control chip 3 may be configured to obtain the initial aqueous humor flow finite element model, aqueous humor property information and aqueous humor inlet condition information from the storage server 2. The initial aqueous humor flow finite element model may characterize the nonlinear relationship between the aqueous humor outlet pressure, the aqueous humor outflow and the aqueous humor outflow rate. The aqueous humor property information may characterize the properties of the simulated aqueous humor set in the finite element simulation software. The aqueous humor property information may include but is not limited to aqueous humor density and aqueous humor dynamic viscosity. The aqueous humor density may be the density of the aqueous humor when the finite element simulation software simulates the flow of aqueous humor. For example, the aqueous humor density may be 997 kg / m3. The aqueous humor dynamic viscosity may be the dynamic viscosity of the aqueous humor when the finite element simulation software simulates the flow of aqueous humor. For example, the aqueous humor dynamic viscosity may be 0.004 Pa·s (Pa·second). The aqueous humor inlet condition information may be the inlet condition of the aqueous humor when the finite element simulation software simulates the flow of aqueous humor. The aqueous humor inlet condition information may include but is not limited to aqueous humor temperature, aqueous humor inlet information and aqueous humor production rate. The aqueous humor temperature may be the temperature of the aqueous humor. For example, the aqueous humor temperature may be 37 degrees Celsius. The aqueous humor production rate may be the rate at which the aqueous humor is produced. For example, the aqueous humor production rate may be 5×10 -8 Kilograms per second. The aqueous humor inlet information may be the location of the aqueous humor inlet. The aqueous humor inlet information may be the location of the posterior chamber ciliary process in the three-dimensional eye model with a drainage valve. For example, the aqueous humor inlet information may include but is not limited to the coordinates of the center of the posterior chamber ciliary process. The coordinates of the center point of the posterior chamber ciliary process in the three-dimensional coordinate system of the model. The three-dimensional coordinate system of the model may be the three-dimensional coordinate system where the three-dimensional eye model with a drainage valve is located. The initial aqueous humor flow finite element model may be represented by the following formula:

[0045]

[0046] Wherein, ρ may represent the density of aqueous humor. u may represent the average flow rate of aqueous humor. K may represent the preset trabecular meshwork permeability. The preset trabecular meshwork permeability may be a preset trabecular meshwork permeability. For example, the preset trabecular meshwork permeability may be 2.3×10 -15 square meters. μ can represent the dynamic viscosity of aqueous humor. p can represent the outlet pressure of aqueous humor. The outlet pressure of aqueous humor can be the pressure at the outlet of aqueous humor. Q can represent the outflow of aqueous humor. It can represent the Nabla operator. It should be noted that in the present disclosure, the aqueous humor outlet pressure can be the intraocular pressure.

[0047] In some embodiments, the main control chip 3 may be configured to generate a finite element model to be solved according to the aqueous humor property information, the aqueous humor inlet condition information and the initial aqueous humor flow finite element model. In practice, the aqueous humor density, the aqueous humor dynamic viscosity and the preset trabecular meshwork permeability may be input into the initial aqueous humor flow finite element model to obtain the finite element model to be solved.

[0048] Optionally, the initial aqueous humor flow finite element model can also be expressed by the following formula:

[0049]

[0050] Among them, G can represent the aqueous humor gravity information.

[0051] The main control chip 3 can be further configured as follows:

[0052] The first step is to generate aqueous humor gravity information according to the aqueous humor density. In practice, the aqueous humor gravity information can be determined as the product of the aqueous humor density and the gravitational acceleration.

[0053] The second step is to generate a finite element model to be solved based on the aqueous humor gravity information, the aqueous humor property information, the aqueous humor inlet condition information and the initial aqueous humor flow finite element model. In practice, the aqueous humor gravity information, the aqueous humor density, the aqueous humor dynamic viscosity and the preset trabecular meshwork permeability can be input into the initial aqueous humor flow finite element model to obtain the finite element model to be solved.

[0054] Therefore, in the process of simulating the flow of aqueous humor, the influence of the gravity of the aqueous humor itself on the flow of aqueous humor is taken into account, thereby improving the accuracy of the simulation results.

[0055] In some embodiments, the main control chip 3 can be configured to perform aqueous humor flow simulation operations on the three-dimensional eye model with drainage valve, and to solve the finite element model to be solved to obtain simulation result information. The aqueous humor flow simulation operation can be an operation of simulating the flow of aqueous humor in the three-dimensional eye model with drainage valve through the finite element simulation software. During the simulation process, aqueous humor will flow in the three-dimensional eye model with drainage valve, such as Figure 4As shown. In practice, the finite element simulation software can be used to perform aqueous humor flow simulation operations on the three-dimensional eye model with a drainage valve according to the aqueous humor property information, the preset aqueous humor initial outlet pressure information and the aqueous humor inlet condition information, and the preset solver can be used to solve the finite element model to be solved to obtain simulation result information. The preset aqueous humor initial outlet pressure information can be the initial pressure of the aqueous humor outlet during the preset aqueous humor flow simulation. For example, the preset aqueous humor initial outlet pressure information can be 15 mmHg (millimeters of mercury). The preset solver can be a preset direct solver. For example, the solver can be a MUMPS solver (Multifrontal Massively Parallel Solver), and the corresponding memory allocation factor can be 1.2. The preset solver can also be a preset iterative solver. For example, the solver can also be a GMRES (Generalized Minimal Residual Method) solver, and the corresponding number of iterations can be 50. The above-mentioned simulation result information may include but is not limited to the average flow rate of aqueous humor, the outflow volume of aqueous humor and the outlet pressure of aqueous humor (ie, intraocular pressure).

[0056] Optionally, the finite element simulation interface may further include an aqueous humor outlet pressure input box and an outlet pressure confirmation control. The aqueous humor outlet pressure input box may be an input box for a user to input the aqueous humor outlet pressure. The aqueous humor outlet pressure may be the pressure at the aqueous humor outlet. The outlet pressure confirmation control may be a control for a user to confirm the aqueous humor outlet pressure.

[0057] Optionally, the main control chip 3 may be further configured as follows:

[0058] The first step is to respond to receiving input operation information sent by the input device and determining that the received input operation information represents the input operation as an operation acting on the outlet pressure confirmation control, obtain the aqueous humor outlet pressure corresponding to the aqueous humor outlet pressure input box from the storage server 2, and determine the aqueous humor outlet pressure as the initial aqueous humor outlet pressure information.

[0059] The second step is to perform an aqueous humor flow simulation operation on the three-dimensional eye model with a drainage valve according to the aqueous humor initial outlet pressure information, and to solve the finite element model to be solved to obtain simulation result information. The finite element simulation software can be used to perform an aqueous humor flow simulation operation on the three-dimensional eye model with a drainage valve according to the aqueous humor property information, the aqueous humor initial outlet pressure information and the aqueous humor inlet condition information, and the preset solver can be used to solve the finite element model to be solved to obtain simulation result information.

[0060] Therefore, simulation users can set the initial outlet pressure of aqueous humor to simulate the complications of different glaucoma surgeries - the effect of bleb scarring on aqueous humor dynamics.

[0061] Optionally, the main control chip 3 may be further configured as follows:

[0062] The first step is to obtain the eyeball radius and initial resistance coefficient model corresponding to the three-dimensional eye structure with drainage valve from the storage server 2. The eyeball radius can be the radius of the eyeball in the three-dimensional eye structure with drainage valve. The initial resistance coefficient model can be expressed by the following formula:

[0063]

[0064] Wherein, Δp may represent the pressure gradient, i.e., the difference between the maximum value of each aqueous humor outlet pressure at different times and the initial aqueous humor outlet pressure represented by the aqueous humor initial outlet pressure information. R may represent the radius of the eyeball. u may represent the average flow velocity of the aqueous humor. a may represent the viscous resistance coefficient. b may represent the inertial resistance coefficient.

[0065] The second step is to input the eyeball radius into the initial resistance coefficient model to obtain the resistance coefficient model to be solved.

[0066] The third step is to solve the above-mentioned finite element model to be solved and the above-mentioned resistance coefficient model to be solved to obtain simulation result information. In practice, the above-mentioned solver can be used to solve the above-mentioned finite element model to be solved and the above-mentioned resistance coefficient model to be solved to obtain the average aqueous humor flow rate, aqueous humor outflow, aqueous humor outlet pressure (i.e., intraocular pressure), viscous resistance coefficient and inertial resistance coefficient. Then, the average aqueous humor flow rate, aqueous humor outflow, aqueous humor outlet pressure (i.e., intraocular pressure), viscous resistance coefficient and inertial resistance coefficient are combined to obtain simulation result information. Among them, the above-mentioned combination method can be character splicing.

[0067] Therefore, the relationship between the viscous drag coefficient and the inertial drag coefficient can be determined and used to evaluate the surgical effect.

[0068] In some embodiments, the main control chip 3 can be configured to generate surgical evaluation information based on the simulation result information. In practice, the main control chip 3 can be configured to combine the preset surgical feasibility information, the simulation result information, the initial aqueous humor outlet pressure information and the three-dimensional eye model with drainage valve in response to determining that the aqueous humor outlet pressure in the simulation result information is less than or equal to the preset aqueous humor outlet pressure to obtain surgical evaluation information. Among them, the preset aqueous humor outlet pressure can be a preset pressure of the aqueous humor outlet. For example, the preset aqueous humor outlet pressure can be 21 mmHg. The preset surgical feasibility information can be information that is preset to characterize that the simulated surgical plan is effective and can be implemented. For example, the preset surgical feasibility information can be "feasible".

[0069] In some embodiments, the main control chip 3 may be configured to control the display device 4 to display the surgical evaluation information.

[0070] Optionally, the main control chip 3 may also be configured to send the surgery evaluation information to the storage server 2 .

[0071] The storage server 2 may be configured to receive the surgical evaluation information sent by the main control chip 3, and add the surgical evaluation information as historical surgical evaluation information to the historical surgical evaluation information set. The historical surgical evaluation information in the historical surgical evaluation information set may be surgical evaluation information completed at a historical time point.

[0072] Therefore, through the surgical evaluation system for glaucoma, the simulation user can simulate different drainage valve implantation schemes, introduce the generation and flow of aqueous humor during the simulation process to improve the authenticity of the simulated aqueous humor flow, and thus evaluate the therapeutic effect of the surgical scheme. The simulation user can also simulate different angle closure angles or different degrees of scarring of the filtering bleb to simulate the effects of drainage valve implantation surgery on different patients. Figure 5 , Figure 6 and Figure 7 As shown, Figure 5 This is an internal test comparison chart of a surgical evaluation system for glaucoma according to some embodiments of the present disclosure, which simulates different chamber angle closure angles to verify the effect of drainage valve implantation surgery. Figure 6 This is an internal test linear comparison diagram of a surgical evaluation system for glaucoma according to some embodiments of the present disclosure, which simulates different angle closure angles to verify the effect of drainage valve implantation surgery. The three broken lines correspond to drainage valve surgical plans from top to bottom: no drainage valve implantation, drainage valve implantation position is the coordinates of the position where the boundary between angle closure and opening is offset 15 degrees from the closed position, and the drainage valve implantation position is the coordinates of the middle point of the angle closure area. Figure 7This is an internal test linear comparison diagram of a surgical evaluation system for glaucoma according to some embodiments of the present disclosure, which simulates different chamber angle closure angles to explore the changes in aqueous humor flow rate caused by different drainage valve implantation surgical schemes.

[0073] In the process of adopting technical solutions to solve the technical problems in the background technology, the following technical problem 2 is often accompanied: after the actual surgical treatment, the target user's emotions will also affect the intraocular pressure, resulting in a low accuracy of the surgical evaluation obtained through simulation. In response to the above technical problem 2, the conventional solution is generally: after the actual surgical treatment, psychological guidance is provided to the target user to improve the effect of the surgical treatment. However, the above conventional solution still has the following problems: different users have different emotions, which have different effects on intraocular pressure. The same surgical plan has different effects on different users. The impact of user emotions on intraocular pressure changes is not considered during the simulation process, resulting in a low accuracy of the surgical evaluation.

[0074] Considering the problems of the above conventional solutions, in the face of the above technical problem 2, in conjunction with AI researchers from universities and combining their own AI algorithms, the following solutions can be adopted:

[0075] Optionally, the above simulation result may also include a simulated intraocular pressure value. The simulated intraocular pressure value may be an aqueous humor outlet pressure. The above main control chip 3 may be further configured as follows:

[0076] The first step is to obtain the eye model information corresponding to the three-dimensional eye model with drainage valve from the storage server 2. The eye model information may include but is not limited to an eye structure information set.

[0077] In the second step, the eye structure information corresponding to the preset chamber angle mark in the above eye structure information set is determined as the first eye structure information. The above preset chamber angle mark can be a unique mark of the pre-set eye chamber angle. The eye structure information in the above corresponding preset chamber angle mark can include the eye angle closure angle. For example, the eye angle closure angle can be 180 degrees.

[0078] The third step is to determine the eye structure information corresponding to the preset drainage valve identifier in the above-mentioned eye structure information set as the second eye structure information. Among them, the above-mentioned preset drainage valve identifier can be an identifier of a drainage valve implanted by a user in advance. The above-mentioned eye structure information corresponding to the preset drainage valve identifier can include drainage valve implantation coordinates and drainage valve diameter. The above-mentioned drainage valve implantation coordinates can characterize the position of the drainage valve in the drainage valve three-dimensional eye model. For example, the above-mentioned drainage valve implantation position can be the coordinates of the middle point of the chamber angle closure area, or it can be the coordinates of the position where the boundary between the chamber angle closure and the open is offset 15 degrees from the closed position. The above-mentioned drainage valve diameter can be the diameter of the drainage valve. The unit of the above-mentioned drainage valve diameter can be micrometers.

[0079] The fourth step is to input the above-mentioned first ocular structure information and the above-mentioned second ocular structure information into a preset postoperative infection probability generation model to obtain the postoperative infection probability. Among them, the above-mentioned preset postoperative infection probability generation model can be a linear function with the above-mentioned first ocular structure information and the above-mentioned second ocular structure information as input and the postoperative infection probability as output. The above-mentioned linear function can be fitted through a postoperative infection sample set. The above-mentioned postoperative infection sample set includes sample first ocular structure information, sample second ocular structure information and corresponding sample postoperative infection probability. The above-mentioned postoperative infection probability can be the probability of wound infection after the operation is performed according to the surgical plan corresponding to the surgical evaluation information. In practice, the eye angle closure angle included in the above-mentioned first ocular structure information and the drainage valve implantation coordinates and drainage valve diameter included in the above-mentioned second ocular structure information can be input into the preset postoperative infection probability generation model to obtain the postoperative infection probability.

[0080] Step 5: Obtain basic user information of the target user from the storage server 2. The target user may be the user of the eye image of the user. The basic user information may include but is not limited to the user's age, gender, and duration of illness.

[0081] Step 6: Perform feature extraction on the postoperative infection probability and the user basic information to obtain a user feature vector. In practice, the postoperative infection probability and the user basic information can be subjected to feature extraction by a preset feature extraction algorithm to obtain a user feature vector. The preset feature extraction algorithm can be a pre-set algorithm for feature vector conversion. For example, the preset feature extraction algorithm can be a principal component analysis method.

[0082] In the seventh step, the user feature vector is input into a preset postoperative emotion classification model to obtain a postoperative emotion type. The preset postoperative emotion classification model may be a pre-set mapping relationship table with the user feature vector as input and the postoperative emotion type as output. The postoperative emotion type may characterize the predicted postoperative emotion of the target user. The postoperative emotion type may be, but is not limited to, one of the following: stable, anxious, depressed.

[0083] In the eighth step, the preset intraocular pressure additional value corresponding to the above-mentioned postoperative emotional type in the preset intraocular pressure additional value set is determined as the intraocular pressure additional value. Among them, each preset intraocular pressure additional value in the above-mentioned preset intraocular pressure additional value set corresponds to a preset emotional type. The above-mentioned preset emotional type may be a preset postoperative emotional type. The above-mentioned preset intraocular pressure additional value may characterize the change in intraocular pressure caused by the preset corresponding emotional type. For example, when the postoperative emotional type is stable, the corresponding preset intraocular pressure additional value may be 0 mmHg. When the postoperative emotional type is anxiety, the corresponding preset intraocular pressure additional value may be 1 mmHg. When the postoperative emotional type is depression, the corresponding preset intraocular pressure additional value may be 3 mmHg.

[0084] The ninth step is to determine the sum of the simulated intraocular pressure value included in the above simulation results and the above intraocular pressure additional value as the assessed intraocular pressure value.

[0085] Step 10: Generate surgical evaluation information based on the above-mentioned assessed intraocular pressure value. In practice, in response to determining that the above-mentioned assessed intraocular pressure value is less than or equal to the preset aqueous humor outlet pressure, the preset surgical feasibility information, the above-mentioned simulation result information, the aqueous humor initial outlet pressure information and the above-mentioned three-dimensional eye model with drainage valve are combined to obtain the surgical evaluation information.

[0086] The above technical solution and its related contents, as an inventive point of the embodiments of the present disclosure, solve the technical problem that "different users have different emotions, which have different effects on intraocular pressure, the same surgical plan has different effects on different users, and the influence of user emotions on intraocular pressure changes is not considered during the simulation process, resulting in low accuracy of surgical evaluation". The factors that lead to low accuracy of surgical evaluation are often as follows: different users have different emotions, which have different effects on intraocular pressure, the same surgical plan has different effects on different users, and the influence of user emotions on intraocular pressure changes is not considered during the simulation process, resulting in low accuracy of surgical evaluation. If the above factors are solved, the effect of improving the accuracy of surgical evaluation can be achieved. In order to achieve this effect, some embodiments of the present disclosure are suitable for glaucoma surgical evaluation systems. After performing aqueous humor dynamics simulation, the user's postoperative emotions are predicted by obtaining user portraits, and the postoperative intraocular pressure is estimated based on the user's postoperative emotions and the results of the simulation, so as to be used to judge the surgical effect of the corresponding surgical plan, thereby improving the accuracy of surgical evaluation. As a result, the safety of glaucoma treatment surgery can be further improved.

[0087] The above-mentioned embodiments of the present disclosure have the following beneficial effects: through the surgical evaluation system applicable to glaucoma of some embodiments of the present disclosure, the safety of glaucoma treatment surgery can be improved. Specifically, the reason for the low safety of glaucoma treatment surgery is that the surgical evaluation system can simulate the aqueous humor outflow pathway (including trabecular meshwork and collecting duct) through a three-dimensional model, but does not take into account the influence of the production of aqueous humor on the flow of aqueous humor, resulting in the evaluation of the surgical effect evaluated by the surgical evaluation system when evaluating the influence of surgical interventions and related complications on intraocular pressure. The accuracy is low, resulting in the low safety of glaucoma treatment surgery. Based on this, the surgical evaluation system applicable to glaucoma of some embodiments of the present disclosure includes: a scanning device, a storage server, a main control chip and a display device, wherein the scanning device is used to scan the user's eye structure, obtain the user's eye image, and send the user's eye image to the main control chip. Thus, the user's eye image can be obtained, thereby improving the accuracy of the simulation. Secondly, the main control chip is configured to receive the user's eye image sent by the scanning device, and generate a three-dimensional eye model with a drainage valve according to the user's eye image. Thus, a three-dimensional structural model of the user's eye after simulating the drainage valve implantation surgery can be obtained, which can be used to simulate the aqueous humor dynamics after the drainage valve implantation surgery, and then the surgical effect of the corresponding drainage valve implantation surgery can be determined. Afterwards, the above-mentioned main control chip is configured to obtain the initial aqueous humor flow finite element model, aqueous humor property information and aqueous humor inlet condition information from the above-mentioned storage server. Among them, the above-mentioned initial aqueous humor flow finite element model represents the nonlinear relationship between the aqueous humor outlet pressure, the aqueous humor outflow and the aqueous humor outflow rate. Thus, the relationship between the aqueous humor outlet pressure and the aqueous humor outflow and the aqueous humor outflow rate can be established, which can be used to simulate the aqueous humor flow. Next, the above-mentioned main control chip is configured to generate a finite element model to be solved according to the above-mentioned aqueous humor property information, the above-mentioned aqueous humor inlet condition information and the above-mentioned initial aqueous humor flow finite element model; the above-mentioned main control chip is configured to perform aqueous humor flow simulation operations on the above-mentioned three-dimensional eye model with drainage valve, and solve the above-mentioned finite element model to be solved to obtain simulation result information. Thus, the flow of aqueous humor after the drainage valve is implanted can be obtained by simulating the dynamics of aqueous humor. Finally, the main control chip is configured to generate surgical evaluation information according to the simulation result information; the main control chip is configured to control the display device to display the surgical evaluation information. Thus, the surgical effect of the drainage valve implantation surgery can be judged by the simulation results. Also, during the simulation process, the surgical evaluation system establishes the relationship between the aqueous humor outlet pressure and the aqueous humor outflow volume and the aqueous humor outflow rate, and takes into account the influence of the production of aqueous humor on the dynamics of aqueous humor, thereby improving the accuracy of the simulation result information, thereby improving the accuracy of the evaluated surgical effect, and further improving the safety of glaucoma treatment surgery.

[0088] The above descriptions are only some preferred embodiments of the present disclosure and an explanation of the technical principles used. Those skilled in the art should understand that the scope of the invention involved in the embodiments of the present disclosure is not limited to the technical solutions formed by a specific combination of the above-mentioned technical features, but should also cover other technical solutions formed by any combination of the above-mentioned technical features or their equivalent features without departing from the above-mentioned inventive concept. For example, the above-mentioned features are replaced with the technical features with similar functions disclosed in the embodiments of the present disclosure (but not limited to) and the technical solutions formed.

Claims

1. A surgical evaluation system for glaucoma, the surgical evaluation system comprising: Scanning device, storage server, main control chip and display device, wherein: A scanning device, used for scanning the eye structure of the user, obtaining an eye image of the user, and sending the eye image of the user to the main control chip; The main control chip is configured to receive the user's eye image sent by the scanning device, and generate a three-dimensional eye model with a drainage valve according to the user's eye image; The main control chip is configured to obtain an initial aqueous humor flow finite element model, aqueous humor property information, and aqueous humor inlet condition information from the storage server, wherein the initial aqueous humor flow finite element model represents a nonlinear relationship among aqueous humor outlet pressure, aqueous humor outflow volume, and aqueous humor outflow rate; The main control chip is configured to generate a finite element model to be solved according to the aqueous humor property information, the aqueous humor inlet condition information and the initial aqueous humor flow finite element model; The main control chip is configured to perform aqueous humor flow simulation operation on the three-dimensional eye model with drainage valve, and solve the finite element model to be solved to obtain simulation result information; The main control chip is configured to generate surgery evaluation information according to the simulation result information; The main control chip is configured to control the display device to display the surgery evaluation information.

2. The surgical evaluation system for glaucoma according to claim 1, wherein: The surgical evaluation system further includes an input device, the input device being used to detect an input operation of a user acting on the display device, and to send input operation information corresponding to the detected input operation to the main control chip, wherein the main control chip is further configured to: Performing a three-dimensional model construction process on the user's eye image to obtain a three-dimensional eye model, and controlling the display device to display the three-dimensional eye model on a finite element simulation interface, wherein the finite element simulation interface further includes various glaucoma-related parameter input boxes and parameter confirmation controls corresponding to various glaucoma-related parameter identifiers, and the glaucoma-related parameter input boxes in the various glaucoma-related parameter input boxes are used for the user to input glaucoma-related parameter information; In response to receiving input operation information sent by the input device and determining that the received input operation information represents that the input operation is an operation acting on the parameter confirmation control, acquiring each glaucoma-associated parameter information corresponding to each glaucoma-associated parameter input box from the storage server, and determining each glaucoma-associated parameter information as a glaucoma-associated parameter information group; According to the glaucoma-related parameter information group, the three-dimensional eye model is updated to obtain a three-dimensional glaucoma model; A three-dimensional eye model with a drainage valve is generated according to the three-dimensional glaucoma model.

3. The surgical evaluation system for glaucoma according to claim 2, wherein: The main control chip is further configured as follows: Controlling the display device to display the three-dimensional glaucoma model on the finite element simulation interface, wherein the finite element simulation interface further includes a drainage valve implantation control and an implantation completion control; In response to receiving input operation information sent by the input device and determining that the received input operation information represents that the input operation is an operation acting on the drainage valve implant control, controlling the display device to display the glaucoma three-dimensional model in a three-dimensional modeling module, wherein the three-dimensional modeling module is displayed in the finite element simulation interface; In response to receiving input operation information sent by the input device, and determining that the received input operation information represents that the input operation is an operation acting on the glaucoma three-dimensional model, updating the glaucoma three-dimensional model according to the received input operation information to obtain an updated glaucoma three-dimensional model, and controlling the display device to display the updated glaucoma three-dimensional model as the glaucoma three-dimensional model in the three-dimensional modeling module; In response to receiving input operation information sent by the input device and determining that the received input operation information represents that the input operation is an operation acting on the implant completion control, the updated glaucoma three-dimensional model currently displayed in the three-dimensional modeling module is determined to be a three-dimensional eye model with a drainage valve.

4. The surgical evaluation system for glaucoma according to claim 2, wherein: The finite element simulation interface also includes an aqueous humor outlet pressure input box and an outlet pressure confirmation control, wherein the aqueous humor outlet pressure input box is used for a user to input the aqueous humor outlet pressure, and the main control chip is further configured as follows: In response to receiving input operation information sent by the input device and determining that the received input operation information represents that the input operation is an operation acting on the outlet pressure confirmation control, acquiring the aqueous humor outlet pressure corresponding to the aqueous humor outlet pressure input box from the storage server, and determining the aqueous humor outlet pressure as the aqueous humor initial outlet pressure information; According to the initial outlet pressure information of the aqueous humor, an aqueous humor flow simulation operation is performed on the three-dimensional eye model with a drainage valve, and the finite element model to be solved is solved to obtain simulation result information.

5. The surgical evaluation system for glaucoma according to claim 2, wherein: The main control chip is further configured as: Acquire the eyeball radius and initial resistance coefficient model corresponding to the three-dimensional eye structure with drainage valve from the storage server; Inputting the eyeball radius into the initial resistance coefficient model to obtain the resistance coefficient model to be solved; The finite element model to be solved and the drag coefficient model to be solved are solved to obtain simulation result information.

6. The surgical evaluation system for glaucoma according to claim 1, wherein: The aqueous humor property information includes aqueous humor density, and the main control chip is further configured to: generating aqueous humor gravity information according to the aqueous humor density; A finite element model to be solved is generated according to the aqueous humor gravity information, the aqueous humor property information, the aqueous humor inlet condition information and the initial aqueous humor flow finite element model.

7. The surgical evaluation system for glaucoma according to claim 1, wherein: The main control chip is also configured to send the surgery evaluation information to the storage server; The storage server is configured to receive the surgery evaluation information sent by the main control chip, and add the surgery evaluation information as historical surgery evaluation information to a historical surgery evaluation information set.

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