Preparation method of vitamin d and pqq anti-aging compound
By preparing a vitamin D and PQQ anti-aging compound, the problem of insufficient coverage of immune regulation and bone health in existing products has been solved, achieving a multi-effect anti-aging effect and improving the product's performance.
Patent Information
- Application Number
- CN202411782332.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-05
- Publication Date
- 2025-03-11
AI Technical Summary
Existing anti-aging products struggle to balance immune regulation and bone health maintenance, resulting in poor effectiveness.
A vitamin D and PQQ anti-aging compound was prepared, containing calcium, nicotinamide, zinc, magnesium, PQQ, phosphopeptide, hop flavonoids, selenium, vitamin K, vitamin D, and other ingredients. Specific mixing and granulation processes were used to form dosage forms such as tablets and powders.
It enhances the immune system, promotes mineral absorption, prevents chronic diseases, improves sleep quality, and effectively solves the problems of slow onset and insufficient efficacy of traditional products, while being harmless to the human body.
Smart Images
Figure CN119586769A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of health food, and in particular to a method for preparing a vitamin D and PQQ anti-aging combination. Background Art
[0002] Aging, as an inevitable stage in the life course, has always accompanied the development of human civilization. Entering the 21st century, people have conducted more in-depth research on aging, and people's understanding of aging has gradually changed. At present, anything that is beneficial to human health and improves the quality of life can be defined as delaying aging. The main ways to delay aging are non-drug and drug. Among them, the non-drug method is to adhere to scientific life rules and maintain good living habits. There are many classifications of drug methods, most of which are taking health care drugs or foods, and their effects are also the most significant. Most of the anti-aging products on the market currently do not take into account the two aspects of immune regulation anti-aging and maintaining bone health, which reduces the effectiveness of anti-aging products. Summary of the invention
[0003] Purpose of the invention: The purpose of the present invention is to provide a method for preparing a vitamin D and PQQ anti-aging combination; it can solve the problem that most of the anti-aging products on the market currently do not take into account both immune regulation and anti-aging and the maintenance of bone health, thereby reducing the use effect of the anti-aging products.
[0004] Technical solution: To solve the above technical problems, according to one aspect of the present invention, more specifically, a method for preparing an anti-aging combination of vitamin D and PQQ, comprising: calcium, niacinamide, zinc, magnesium, PQQ, complex protein phosphopeptide, hop flavonoids, selenium, vitamin K, vitamin D, auxiliary materials and adhesives.
[0005] Furthermore, the auxiliary material is one or more of gum arabic, maltodextrin, microcrystalline cellulose, sodium starch octenylsuccinate, hydroxypropyl methylcellulose, sodium ascorbate, magnesium stearate, sodium carboxymethyl starch, and sunflower oil.
[0006] Furthermore, the anti-aging compound includes the following components by weight: 350-1100 parts of calcium, 50-1000 parts of niacinamide, 100-1500 parts of zinc, 80-370 parts of magnesium, 10-35 parts of PQQ, 10-45 parts of complex protein phosphopeptide, 15-35 parts of hop flavonoids, 0.1-0.5 parts of selenium, 0.017-0.22 parts of vitamin K, 0.0018-0.023 parts of vitamin D, 600-3500 parts of auxiliary materials, and 240-1400 parts of adhesives.
[0007] According to another aspect of the present invention, a method for preparing a vitamin D and PQQ anti-aging combination is provided. The method is based on the components in the vitamin D and PQQ anti-aging combination described above, and specifically comprises the following steps:
[0008] S1. Preparation of hop flavonoids;
[0009] S2, the raw materials except the adhesive are sieved through a 60-mesh sieve to prepare a dry mixed mixture;
[0010] S3, mixing the dry mix with the adhesive to form a wet mix;
[0011] S4, wet mixing the mixture into granules;
[0012] S5, particle selection and drying;
[0013] S6. Select the dried particles to make an anti-aging combination.
[0014] Furthermore, in S1, the preparation of hop flavonoids specifically comprises the following steps:
[0015] ①, boil and extract hops twice with ethanol or methanol aqueous solution with a weight concentration of 50-75% of 4-7 times the dry weight of the raw material, each time for 0.5-1.5 hours, combine the extracts, filter, and vacuum concentrate the filtrate until it is alcohol-free to obtain an extract;
[0016] ②, the extract is directly adsorbed into the macroporous adsorption resin to be saturated, first eluted with 50-65% ethanol aqueous solution by weight, and the eluate is collected until the effluent is clear; then eluted with 75-95% ethanol aqueous solution by weight, and the eluate is collected, and the eluate is collected until the effluent is clear;
[0017] ③. Combine the eluates, concentrate until there is no alcohol, and dry them.
[0018] Furthermore, in S3, the method of mixing the dry mixed mixture with the adhesive is: wet mixing for 40 minutes, and the temperature detected by the thermostat is set between 20°C and 45°C.
[0019] Furthermore, in S4, the method of preparing granules from the wet mixed mixture is: passing the wet mixed mixture through an 18-mesh sieve, and granulating the mixture under the monitoring of a particle size detector to prepare granulated particles.
[0020] Furthermore, in S5, the particle selection and drying method is: the granulated particles are selected by an automatic sorter, the temperature detected by the thermostat is set between 47-53° C., and the drying time is set to 2 hours to prepare dry particles.
[0021] Furthermore, in S6, the method for preparing the anti-aging combination is: passing the dried granules through a 16-mesh sieve, performing uniform granulation and weighing to prepare granulated granules, inputting the prepared granules into a tablet press, pressing them into a specified weight to prepare a bare flake granular combination, and after testing and weighing, preparing the combination into any one of tablets, powders, pills, granules, syrups, suspensions, capsules, mixtures, powders and pellets as needed.
[0022] Beneficial effects: The hop flavonoids contained in it are a powerful antioxidant. The polyphenol compounds it contains can remove free radicals in the body and neutralize the damage to cells caused by oxidative stress. This antioxidant effect not only helps to delay aging and keep the skin young, but also enhances the function of the immune system and prevents the occurrence of various chronic diseases. The antioxidant effect not only helps to delay aging and keep the skin young, but also enhances the function of the immune system and prevents the occurrence of various chronic diseases, such as cardiovascular disease, cancer, etc. Hop flavonoids also have a significant calming and sleeping effect, can relieve mental stress, help people relax their body and mind, enter a deep sleep state, thereby improving sleep quality, and can effectively solve the problem of combining the functions of promoting mineral absorption and treating dental caries with traditional anti-osteoporosis drugs such as phosphopeptides, niacinamide, vitamin D, vitamin K, etc., and overcomes the technical defects of similar products that are usually slow in onset, insufficient in efficacy, and cannot take into account multiple effects. It is harmless to the human body and has stable product quality. BRIEF DESCRIPTION OF THE DRAWINGS
[0023] Figure 1 is a schematic diagram of the method flow chart. DETAILED DESCRIPTION
[0024] In order to make the technical solution of the present invention clearer, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.
[0025] Example 1
[0026] The first step is the preparation of hop flavonoids: ①, hops are boiled and extracted twice with 50% ethanol or methanol aqueous solution with a weight concentration of 4 times the dry weight of the raw material, each time for 0.5 hour, the extracts are combined, filtered, and the filtrate is vacuum concentrated to be alcohol-free to obtain an extract; ②, the extract is directly adsorbed to saturation by a macroporous adsorption resin, first eluted with a 50% ethanol aqueous solution by weight, and the eluate is collected until the effluent is clear; then eluted with a 75% ethanol aqueous solution by weight, the eluate is collected, and the eluate is collected until the effluent is clear; ③, the eluate is combined, concentrated to be alcohol-free, and dried.
[0027] In the second step, 350 parts of calcium, 50 parts of niacinamide, 100 parts of zinc, 80 parts of magnesium, 10 parts of PQQ, 10 parts of complex protein phosphopeptide, 15 parts of hop flavonoids, 0.1 parts of selenium, 0.017 parts of vitamin K, 0.0018 parts of vitamin D, arabic gum, maltodextrin, microcrystalline cellulose, sodium starch glycolate, hydroxypropyl methylcellulose, sodium ascorbate, magnesium stearate, sodium carboxymethyl starch, and 600 parts of one or more of sunflower oil are sieved through a 60-mesh sieve to prepare a dry mixed mixture.
[0028] In the third step, the dry mixed mixture is wet mixed with 240 parts of adhesive for 40 minutes, and the temperature detected by the thermostat is set at 20° C. to obtain a wet mixed mixture.
[0029] In the fourth step, the wet mixed mixture is passed through an 18-mesh sieve and granulated under the monitoring of a particle size detector to prepare granulated particles.
[0030] In the fifth step, the granulated particles are selected by an automatic sorter, the temperature of the thermostat is set at 47° C., and the drying time is set at 2 hours to prepare dry particles.
[0031] The sixth step is to pass the dried granules through a 16-mesh sieve, perform uniform granulation, weigh them, and make granules. The granules are input into a tablet press and pressed into a specified weight to make a bare sheet granular combination. After testing and weighing, the granules are made into any one of tablets, powders, pills, granules, syrups, suspensions, capsules, mixtures, powders, and pellets as needed.
[0032] Example 2
[0033] The first step is the preparation of hop flavonoids: ①, hops are boiled and extracted twice with ethanol or methanol aqueous solution with a weight concentration of 60% of 5 times the dry weight of the raw material, each time for 1 hour, the extracts are combined, filtered, and the filtrate is vacuum concentrated to be alcohol-free to obtain an extract; ②, the extract is directly adsorbed to saturation by a macroporous adsorption resin, first eluted with an ethanol aqueous solution with a weight concentration of 60%, and the eluate is collected until the effluent is clear; then eluted with an ethanol aqueous solution with a weight concentration of 80%, the eluate is collected, and the eluate is collected until the effluent is clear; ③, the eluates are combined, concentrated to be alcohol-free, and dried.
[0034] In the second step, 500 parts of calcium, 400 parts of niacinamide, 500 parts of zinc, 150 parts of magnesium, 20 parts of PQQ, 20 parts of complex protein phosphopeptide, 20 parts of hop flavonoids, 0.2 parts of selenium, 0.019 parts of vitamin K, 0.002 parts of vitamin D, arabic gum, maltodextrin, microcrystalline cellulose, sodium starch glycolate, hydroxypropyl methylcellulose, sodium ascorbate, magnesium stearate, sodium carboxymethyl starch, and 1500 parts of one or more of sunflower oil are sieved through a 60-mesh sieve to prepare a dry mixed mixture.
[0035] In the third step, the dry mixed mixture is wet mixed with 650 parts of adhesive for 40 minutes, and the temperature detected by the thermostat is set at 30° C. to obtain a wet mixed mixture.
[0036] In the fourth step, the wet mixed mixture is passed through an 18-mesh sieve and granulated under the monitoring of a particle size detector to prepare granulated particles.
[0037] In the fifth step, the granulated particles are selected by an automatic sorter, the temperature of the thermostat is set at 49° C., and the drying time is set at 2 hours to prepare dry particles.
[0038] In the sixth step, the dried granules are passed through a 16-mesh sieve, uniformly sized and weighed to form sized granules, and the granules are fed into a tablet press and pressed into a specified weight to form a bare granular combination. After testing and weighing, the combination is formed into any one of tablets, powders, pills, granules, syrups, suspensions, capsules, mixtures, powders and dripping pills as needed. Example 3
[0039] The first step is the preparation of hop flavonoids: ①, hops are boiled and extracted twice with 70% ethanol or methanol aqueous solution with a weight concentration of 6 times the dry weight of the raw material, each time for 1 hour, the extracts are combined, filtered, and the filtrate is vacuum concentrated to be alcohol-free to obtain an extract; ②, the extract is directly adsorbed to saturation by a macroporous adsorption resin, first eluted with a 60% ethanol aqueous solution by weight, and the eluate is collected until the effluent is clear; then eluted with an 85% ethanol aqueous solution by weight, the eluate is collected, and the eluate is collected until the effluent is clear; ③, the eluates are combined, concentrated to be alcohol-free, and dried.
[0040] In the second step, 800 parts of calcium, 700 parts of niacinamide, 800 parts of zinc, 260 parts of magnesium, 30 parts of PQQ, 35 parts of complex protein phosphopeptide, 30 parts of hop flavonoids, 0.3 parts of selenium, 0.021 parts of vitamin K, 0.0021 parts of vitamin D, gum arabic, maltodextrin, microcrystalline cellulose, sodium starch glycolate, hydroxypropyl methylcellulose, sodium ascorbate, magnesium stearate, sodium carboxymethyl starch, and 2500 parts of one or more of sunflower oil are sieved through a 60-mesh sieve to prepare a dry mixed mixture.
[0041] In the third step, the dry mixed mixture is wet mixed with 1000 parts of the adhesive for 40 minutes, and the temperature detected by the thermostat is set at 35° C. to obtain a wet mixed mixture.
[0042] In the fourth step, the wet mixed mixture is passed through an 18-mesh sieve and granulated under the monitoring of a particle size detector to prepare granulated particles.
[0043] In the fifth step, the granulated particles are selected by an automatic sorter, the temperature of the thermostat is set at 51° C., and the drying time is set at 2 hours to prepare dry particles.
[0044] The sixth step is to pass the dried granules through a 16-mesh sieve, perform uniform granulation, weigh them, and make granules. The granules are input into a tablet press and pressed into a specified weight to make a bare sheet granular combination. After testing and weighing, the granules are made into any one of tablets, powders, pills, granules, syrups, suspensions, capsules, mixtures, powders, and pellets as needed.
[0045] Example 4
[0046] The first step is the preparation of hop flavonoids: ①, hops are boiled and extracted twice with 75% ethanol or methanol aqueous solution with a weight concentration of 7 times the dry weight of the raw material, each time for 1.5 hours, the extracts are combined, filtered, and the filtrate is vacuum concentrated to be alcohol-free to obtain an extract; ②, the extract is directly adsorbed to saturation by a macroporous adsorption resin, first eluted with a 65% ethanol aqueous solution by weight, and the eluate is collected until the effluent is clear; then eluted with a 95% ethanol aqueous solution by weight, the eluate is collected, and the eluate is collected until the effluent is clear; ③, the eluates are combined, concentrated to be alcohol-free, and dried.
[0047] In the second step, 1100 parts of calcium, 1000 parts of niacinamide, 1500 parts of zinc, 370 parts of magnesium, 35 parts of PQQ, 45 parts of complex protein phosphopeptide, 35 parts of hop flavonoids, 0.5 parts of selenium, 0.22 parts of vitamin K, 0.0023 parts of vitamin D, arabic gum, maltodextrin, microcrystalline cellulose, sodium starch glycolate, hydroxypropyl methylcellulose, sodium ascorbate, magnesium stearate, sodium carboxymethyl starch, and 3500 parts of one or more of sunflower oil are sieved through a 60-mesh sieve to prepare a dry mixed mixture.
[0048] In the third step, the dry mixed mixture is wet mixed with 1400 parts of the adhesive for 40 minutes, and the temperature detected by the thermostat is set at 45° C. to obtain a wet mixed mixture.
[0049] In the fourth step, the wet mixed mixture is passed through an 18-mesh sieve and granulated under the monitoring of a particle size detector to prepare granulated particles.
[0050] In the fifth step, the granulated particles are selected by an automatic sorter, the temperature of the thermostat is set at 53°C, and the drying time is set at 2 hours to prepare dry particles.
[0051] The sixth step is to pass the dried granules through a 16-mesh sieve, perform uniform granulation, weigh them, and make granules. The granules are input into a tablet press and pressed into a specified weight to make a bare sheet granular combination. After testing and weighing, the granules are made into any one of tablets, powders, pills, granules, syrups, suspensions, capsules, mixtures, powders, and pellets as needed.
[0052] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.
Claims
1. A vitamin D and PQQ anti-aging combination, characterized in that: include: Calcium, niacinamide, zinc, magnesium, PQQ, complex protein phosphopeptide, hop flavonoids, selenium, vitamin K, vitamin D, excipients and adhesives.
2. The anti-aging combination of vitamin D and PQQ according to claim 1, characterized in that: The auxiliary materials are one or more of gum arabic, maltodextrin, microcrystalline cellulose, sodium starch octenylsuccinate, hydroxypropyl methylcellulose, sodium ascorbate, magnesium stearate, sodium carboxymethyl starch, and sunflower oil.
3. The anti-aging combination of vitamin D and PQQ according to claim 1, characterized in that: The anti-aging compound includes the following components by weight: 350-1100 parts of calcium, 50-1000 parts of niacinamide, 100-1500 parts of zinc, 80-370 parts of magnesium, 10-35 parts of PQQ, 10-45 parts of complex protein phosphopeptide, 15-35 parts of hop flavonoids, 0.1-0.5 parts of selenium, 0.017-0.22 parts of vitamin K, 0.0018-0.023 parts of vitamin D, 600-3500 parts of auxiliary materials, and 240-1400 parts of adhesives.
4. A method for preparing an anti-aging combination of vitamin D and PQQ, characterized in that: The method is implemented based on the components in the vitamin D and PQQ anti-aging combination described in claims 1-3, and specifically comprises the following steps: S1. Preparation of hop flavonoids; S2, the raw materials except the adhesive are sieved through a 60-mesh sieve to prepare a dry mixed mixture; S3, mixing the dry mix with the adhesive to form a wet mix; S4, wet mixing the mixture into granules; S5, particle selection and drying; S6. Select the dried particles to make an anti-aging combination.
5. The method for preparing a vitamin D and PQQ anti-aging combination according to claim 4, characterized in that: In S1, the preparation of hop flavonoids specifically comprises the following steps: ①, boil and extract hops twice with ethanol or methanol aqueous solution with a weight concentration of 50-75% of 4-7 times the dry weight of the raw material, each time for 0.5-1.5 hours, combine the extracts, filter, and vacuum concentrate the filtrate until it is alcohol-free to obtain an extract; ②, the extract is directly adsorbed into the macroporous adsorption resin to be saturated, first eluted with 50-65% ethanol aqueous solution by weight, and the eluate is collected until the effluent is clear; then eluted with 75-95% ethanol aqueous solution by weight, and the eluate is collected, and the eluate is collected until the effluent is clear; ③. Combine the eluates, concentrate until there is no alcohol, and dry them.
6. The method for preparing a vitamin D and PQQ anti-aging combination according to claim 5, characterized in that: In S3, the dry mixed mixture and the adhesive are mixed by wet mixing for 40 minutes, and the temperature detected by the thermostat is set between 20°C and 45°C.
7. The method for preparing a vitamin D and PQQ anti-aging combination according to claim 6, characterized in that: In S4, the method for preparing granules from the wet mixed mixture is: passing the wet mixed mixture through an 18-mesh sieve, and granulating the mixture under the monitoring of a particle size detector to prepare granulated particles.
8. The method for preparing a vitamin D and PQQ anti-aging combination according to claim 7, characterized in that: In S5, the particle selection and drying method is: the granulated particles are selected by an automatic sorter, the temperature detected by the thermostat is set between 47-53° C., and the drying time is set to 2 hours to prepare dry particles.
9. The method for preparing a vitamin D and PQQ anti-aging combination according to claim 8, characterized in that: In S6, the method for preparing the anti-aging combination is: passing the dried granules through a 16-mesh sieve, uniformly granulating and weighing to prepare granulated granules, inputting the prepared granules into a tablet press, pressing them into a specified weight to prepare a bare flake granular combination, and after testing and weighing, preparing the combination into any one of tablets, powders, pills, granules, syrups, suspensions, capsules, mixtures, powders and pellets as needed.