Composition for inhibiting color change of whitening agent as well as preparation method and application of composition

Abstract

The invention belongs to the technical field of cosmetics, and discloses a composition for inhibiting color change of a whitening agent as well as a preparation method and application of the composition. The composition disclosed by the invention comprises the following components: pentaerythritol tetra (bis-tert-butyl hydroxy hydrocinnamic acid) ester, sodium pyrosulfite and astaxanthin. According to the invention, pentaerythritol tetra (bis-tert-butylhydroxyhydrocinnamate) ester, sodium pyrosulfite and astaxanthin are reasonably compounded, the three components play a synergistic role, and discoloration of the whitening agent is inhibited by interrupting free radicals, inhibiting electron transition, absorbing ultraviolet rays, inhibiting free radical reaction and the like.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and particularly relates to a composition for inhibiting discoloration of a whitening agent, and a preparation method and application thereof. Background Art

[0002] The discoloration of cosmetics mainly includes the oxidation of oils and fats, discoloration of polysaccharides, discoloration of polyphenols, and discoloration of flavors. Cosmetics are prone to discoloration due to the influence of many factors, including temperature, active water content, oxygen content, light, ions and other related factors. Oxygen free radicals, ions, and light energy will affect the structure of active ingredients, causing the active ingredients to change color. For example, phenolic compounds in spices, such as ethyl maltol and eugenol, will produce red or brown substances when they meet with flavors containing iron ions. This is mainly because phenolic hydroxyl groups can react with ferric chloride to develop colors, which can be used as a method to judge phenol or iron ions. For another example, under sunlight, the color of raw materials containing indole, methyl anthranilate, and eugenol will deepen. In addition, chemical reactions will also occur between active ingredients under certain conditions. For example, tranexamic acid and polyhydroxy sugar derivatives will turn brown when used in high-temperature compounding. This is mainly because the interaction between the two will produce a Maillard reaction similar to that of the Maillard reaction. The Maillard reaction is a non-enzymatic browning reaction that produces brown-black macromolecules. Studies have found that when tranexamic acid and polyhydroxy sugar derivatives exist alone in an aqueous system, there is no color change at high temperatures, but when the two are used together, the browning phenomenon will be aggravated.

[0003] At present, the discoloration problem of whitening cosmetics is a major issue that plagues product development. Traditionally, most people add antioxidants to whitening cosmetics to avoid discoloration of whitening agents. For example, commonly used antioxidants include vitamin C and vitamin E, but vitamin C itself is highly active and has discoloration problems. As an antioxidant, vitamin E has limited antioxidant capacity and feels sticky on the skin.

[0004] Therefore, it is necessary to develop a product that can effectively inhibit the discoloration of whitening agents. Summary of the invention

[0005] The present invention aims to solve at least one of the technical problems existing in the above-mentioned prior art. To this end, the present invention provides a composition for inhibiting discoloration of whitening agents, a preparation method and application thereof, and the composition can effectively solve the problem of darkening and discoloration of whitening products caused by light and high temperature.

[0006] In a first aspect of the present invention, a composition is provided, comprising the following components: pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), sodium pyrosulfite and astaxanthin.

[0007] In some embodiments of the present invention, the composition comprises the following components in parts by weight: 30-70 parts of pentaerythritol tetrakis(di-tert-butylhydroxyhydrocinnamate), 30-70 parts of sodium pyrosulfite and 0.1-10 parts of astaxanthin.

[0008] In some embodiments of the present invention, the composition comprises the following components, measured in parts by weight: 35-65 parts of pentaerythritol tetrakis(di-tert-butylhydroxyhydrocinnamate), 35-65 parts of sodium pyrosulfite and 0.1-5 parts of astaxanthin.

[0009] In some embodiments of the present invention, the composition comprises the following components in parts by weight: 40-60 parts of pentaerythritol tetrakis(di-tert-butylhydroxyhydrocinnamate), 40-60 parts of sodium pyrosulfite and 0.1-1 part of astaxanthin.

[0010] The second aspect of the present invention provides a method for preparing the composition according to the first aspect of the present invention, comprising the following steps:

[0011] The pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), sodium pyrosulfite and astaxanthin are mixed to obtain the composition.

[0012] The third aspect of the present invention provides a cosmetic comprising the composition according to the first aspect of the present invention.

[0013] In some embodiments of the present invention, the cosmetic further comprises a whitening agent.

[0014] In some embodiments of the present invention, the whitening agent includes at least one of phenylethylresorcinol, ascorbic acid and tranexamic acid.

[0015] In some embodiments of the present invention, the content of the composition in the cosmetic is 0.1-5 wt %.

[0016] In some embodiments of the present invention, the content of the composition in the cosmetic is 0.1-1 wt %.

[0017] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0018] The present invention rationally compounds pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate), sodium pyrosulfite and astaxanthin, and the three components play a synergistic role, and inhibit the discoloration of the whitening agent in multiple dimensions by interrupting free radicals, inhibiting electron transitions, absorbing ultraviolet rays, inhibiting free radical reactions, etc.; when the composition of the present invention is used in whitening cosmetics, the components in the composition themselves will not aggravate the darkening of the color of the product, and the discoloration of the product under light and high temperature conditions can be significantly improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 The pictures are of the creams of Application Examples 1-3 and Comparative Example 4 before and after being placed for 2 weeks;

[0020] Figure 2 The pictures are of the facial creams of Application Example 4 and Comparative Example 5 before and after being placed for 2 weeks;

[0021] Figure 3 The pictures are of the facial creams of Application Example 5 and Comparative Example 6 before and after being placed for 2 weeks;

[0022] Figure 4 The pictures are of the creams of Application Example 1 and Comparative Examples 1-4, 8-10 before and after being placed for 2 weeks;

[0023] Figure 5 The pictures are of the facial creams of Application Example 2 and Comparative Example 7 before and after being placed for 2 weeks;

[0024] Figure 6 These are pictures of the facial creams of Application Examples 3-5 and Comparative Examples 4-6 after being exposed to high temperature for 2 months. DETAILED DESCRIPTION

[0025] In order to make the technical scheme of the present invention more clearly understood by those skilled in the art, the following embodiments are listed for illustration. It should be pointed out that the following embodiments do not limit the protection scope of the present invention.

[0026] Unless otherwise specified, the raw materials, reagents or devices used in the present invention can be obtained from conventional commercial channels or by existing known methods.

[0027] In the examples of the present invention, pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate) ester was purchased from BASF (China) Co., Ltd., sodium metabisulfite and astaxanthin were purchased from Guangzhou Nova Biotechnology Co., Ltd., and phenethyl resorcinol was purchased from Dezhixin Flavors & Fragrances (Shanghai) Co., Ltd.

[0028] Examples 1-3

[0029] Examples 1-3 provide a composition respectively, and the specific formula of the composition is shown in Table 1; the unit is part by weight.

[0030] Table 1

[0031]

[0032]

[0033] The composition in Table 1 is prepared by mixing pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), sodium pyrosulfite and astaxanthin.

[0034] Application Examples 1-5

[0035] Application Examples 1-5 provide a facial cream respectively, and the specific formula is shown in Table 2; the unit is wt%.

[0036] Table 2

[0037]

[0038]

[0039] The preparation method of the facial cream of Application Examples 1-5 comprises the following steps:

[0040] Mix the ingredients in phase A evenly according to the proportions in Table 2, dissolve and stir evenly at 80°C, mix the ingredients in phase B evenly, heat to 80°C, add the phase B mixture to phase A, homogenize for 10 minutes, then cool to 40°C, add phase C and phase D, and homogenize for 2 minutes.

[0041] Application Comparative Examples 1-10

[0042] Comparative Examples 1-10 provide a facial cream respectively, and the specific formula is shown in Table 3; the unit is wt%.

[0043] Table 3

[0044]

[0045]

[0046] The preparation method of the facial cream of Application Comparative Examples 1-10 is the same as that of the Application Examples.

[0047] Light discoloration effect test

[0048] Test samples: facial creams prepared according to Application Examples 1-5 and Comparative Examples 1-10.

[0049] Test method: Place each group of test samples indoors under sunlight for 2 weeks, and compare the color change of each group of creams.

[0050] Discoloration of Application Examples 1-5 and Comparative Examples 4-6

[0051] like Figure 1 As shown, Figure 1 (a) is a picture before irradiation, and the samples from left to right correspond to application comparative example 4, application example 1, application example 2, and application example 3; Figure 1 (b) is the picture after 2 weeks of irradiation. The order of sample arrangement is the same as Figure 1 (a) The same.

[0052] like Figure 2 As shown, Figure 2 (a) is a picture before irradiation, and the samples from left to right correspond to application comparative example 5 and application example 4; Figure 2 (b) is the picture after 2 weeks of irradiation. The order of sample arrangement is the same as Figure 2 (a) The same.

[0053] like Figure 3 As shown, Figure 3 (a) is a picture before irradiation, and the samples from left to right correspond to application comparative example 6 and application example 5; Figure 3 (b) is the picture after 2 weeks of irradiation. The order of sample arrangement is the same as Figure 3 (a) The same.

[0054] Comparing the application examples 1-3 and the application comparative example 4 without adding any color-inhibiting component, Figure 1 It can be seen that after adding the composition of Examples 1-3, the discoloration of the paste is alleviated. Figure 2 , Figure 3 It can be seen that when the whitening agent is replaced by ascorbic acid and tranexamic acid, the discoloration is also suppressed. It is confirmed that the composition of the present invention has the effect of suppressing the discoloration of structural analogs such as phenylethylresorcinol, ascorbic acid, and tranexamic acid.

[0055] Discoloration of Application Example 1, Application Comparative Examples 1-4, and Application Comparative Examples 8-10

[0056] like Figure 4 As shown, Figure 4 (a) is a picture before irradiation, and the samples from left to right correspond to Application Example 1, Application Comparative Example 1, Application Comparative Example 2, Application Comparative Example 3, Application Comparative Example 4, Application Comparative Example 8, Application Comparative Example 9, and Application Comparative Example 10; Figure 4 (b) is the picture after 2 weeks of irradiation. The order of sample arrangement is the same as Figure 4 (a) The same.

[0057] from Figure 4It can be seen that 0.1% of the composition is added in Application Example 1, and 0.1% of pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamic acid) ester, sodium pyrosulfite, and astaxanthin are added in the comparative example, as well as 0.05% pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamic acid) ester + 0.05% sodium pyrosulfite, 0.05% pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamic acid) ester + 0.05% astaxanthin, and 0.05% sodium pyrosulfite + 0.05% astaxanthin. It can be seen that Application Example 1 has a stronger discoloration inhibition effect. That is, it is explained that under the condition of the same amount of discoloration inhibition component added, the composition in the application example has a stronger discoloration effect; the discoloration of Comparative Examples 8-10 is significantly more serious than that of Application Example 1, which confirms that there is a synergistic effect of inhibiting discoloration between pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamic acid) ester, sodium pyrosulfite, and astaxanthin in the composition of the present invention.

[0058] This study believes that the discoloration of phenethyl resorcinol is due to the fact that the component contains phenolic hydroxyl groups, which can form a p-π conjugated structure with the benzene ring. The larger the conjugated group, the darker the color. It is easier to form a free radical structure after ultraviolet irradiation, thereby reacting. In the application example, pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate), sodium pyrosulfite, astaxanthin and other components are included. Pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamic acid) ester, sodium pyrosulfite, and astaxanthin are all antioxidants. It is speculated that the reason why the ingredients in the composition of the present invention can synergistically inhibit the discoloration of the whitening agent is that the conjugated double bond of astaxanthin is longer than the conjugated structure of phenethyl resorcinol, and it can provide electrons to free radicals or attract unpaired electrons of free radicals, which may affect the electron cloud structure of the P-π bond of phenethyl resorcinol, thereby affecting its reactivity with free radicals, and preferentially providing electrons to free radicals; sodium pyrosulfite will produce reducing components under light, destroy unsaturated bonds, and inhibit the color deepening of active ingredients caused by red shift of chromophores; pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamic acid) ester can capture oxygen free radicals, reduce their attack on active ingredients, and thus reduce the discoloration of the efficacy component. Therefore, the composition of the present invention synergistically inhibits the color change of active ingredients in multiple dimensions by changing the electronic structure of phenethyl resorcinol, destroying the unsaturated bonds of active ingredients, and capturing active oxygen free radicals. The composition of the present invention also has a certain discoloration inhibition effect on ascorbic acid and tranexamic acid.

[0059] Discoloration of Application Example 2 and Comparative Example 7

[0060] like Figure 5 As shown, Figure 5 (a) is a picture before irradiation, and the samples from left to right correspond to Application Example 2 and Application Comparative Example 7; Figure 5 (b) is a picture after irradiation for 2 weeks, and the samples from left to right correspond to Application Comparative Example 7 and Application Example 2.

[0061] from Figure 5 It can be seen that compared with the commonly used antioxidant tocopherol acetate, the application example 2 added with the composition of the present invention has a stronger anti-discoloration ability than the application comparison example 7 added with tocopherol acetate, thus proving that the anti-discoloration ability of the composition of the present invention is better than the antioxidants commonly used in the cosmetics field.

[0062] High temperature discoloration effect test

[0063] Test samples: facial creams prepared in Application Examples 3-5 and Comparative Examples 4-6.

[0064] Test method: After placing each group of test samples at a high temperature of 48°C for 2 months, compare the color change of each group of creams.

[0065] like Figure 6 As shown, Figure 6 The results are after 2 months; Figure 6 The samples in (a) correspond to Application Example 3 and Application Comparative Example 4 from left to right; Figure 6 The samples in (b) correspond to Application Example 4 and Application Comparative Example 5 from left to right; Figure 6 The samples in (c) correspond to Application Example 5 and Application Comparative Example 6 from left to right.

[0066] from Figure 6 It can be seen that the composition of the present invention also has an inhibitory effect on the discoloration of phenylethylresorcinol, ascorbic acid and tranexamic acid at high temperatures.

[0067] The preferred embodiments of the present invention are specifically described above, but the invention is not limited to the embodiments. Those skilled in the art may make various equivalent modifications or substitutions without violating the spirit of the invention. These equivalent modifications or substitutions are all included in the scope defined by the claims of this application.

Claims

1. A composition, characterized in that The composition comprises the following components: pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), sodium pyrosulfite and astaxanthin.

2. The composition according to claim 1, characterized in that The composition comprises the following components in parts by weight: 30-70 parts of pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), 30-70 parts of sodium pyrosulfite and 0.1-10 parts of astaxanthin.

3. The composition according to claim 2, characterized in that The composition comprises the following components in parts by weight: 35-65 parts of pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), 35-65 parts of sodium pyrosulfite and 0.1-5 parts of astaxanthin.

4. The composition according to claim 3, characterized in that The composition comprises the following components in parts by weight: 40-60 parts of pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), 40-60 parts of sodium pyrosulfite and 0.1-1 part of astaxanthin.

5. The method for preparing the composition according to any one of claims 1 to 4, characterized in that: The following steps are involved: The pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), sodium pyrosulfite and astaxanthin are mixed to obtain the composition.

6. A cosmetic, characterized in that: The cosmetic comprises the composition according to any one of claims 1 to 4.

7. The cosmetic according to claim 6, characterized in that: The cosmetic also includes a whitening agent.

8. The cosmetic according to claim 7, characterized in that: The whitening agent includes at least one of phenylethylresorcinol, ascorbic acid and tranexamic acid.

9. The cosmetic according to claim 6, characterized in that: The content of the composition is 0.1-5wt%.

10. The cosmetic according to claim 9, characterized in that: The content of the composition is 0.1-1 wt%.

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