Traditional Chinese medicine no-wash hand sanitizer and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine no-wash hand sanitizer and a preparation method thereof. The traditional Chinese medicine no-wash hand sanitizer is prepared from 0.5% of fructus forsythiae essential oil, 0.5% of herba schizonepetae essential oil, 0.5% of herba elsholtziae essential oil, 0.7% of cassia twig essential oil, 0.7% of hopleaf essential oil, 0.7% of bergamot essential oil, 0.4% of gel, 3% of emollient, 0.4% of humectant, 0.2%-0.6% of pH regulator, an emulsifier and deionized water. The main components of the traditional Chinese medicine no-wash hand sanitizer are traditional Chinese medicine extracts, so that the traditional Chinese medicine no-wash hand sanitizer can better permeate skin and quickly kill pathogenic bacteria, and has no damage or irritation to normal skin and mucosal tissues.

Description

Technical Field

[0001] The invention relates to the technical field of hand sanitizer, and in particular to a traditional Chinese medicine free-rinse hand sanitizer and a preparation method thereof. Background Art

[0002] Hand sanitizer is a skin care cleaning liquid used to clean hands. It removes dirt and attached bacteria on hands through mechanical friction and surfactants, with or without water. In my country, hand washing products have also gone through kerosene, gasoline, washing powder, soap, perfumed soap and hand sanitizer. Compared with traditional absorption products, hand sanitizer has the advantages of strong practicality, more diversified ingredients, full utilization, less waste, and avoidance of cross contamination. With the maturity of production technology, hand sanitizer is no longer a simple cleaning product, it also plays a role in skin care, antibacterial, sterilization and moisturizing.

[0003] With the progress of society, people's requirements for hand sanitizers are increasing day by day, and wash-free hand sanitizers are born. Wash-free hand sanitizers are not limited by water sources and can be used for water-free hand disinfection in environments that do not require water and soap, such as hospitals, banks, supermarkets, government agencies, enterprises and institutions, theaters, troops, entertainment venues, universities, primary and secondary schools, kindergartens, families, hotels, restaurants, airports, docks, railway stations and tourism. In the prior art, the main component of wash-free hand sanitizers is alcohol. Scientists have conducted experiments and found that people who like to use hand sanitizers have a 6-fold risk of contracting diseases than those who use soap. In addition, alcohol will accelerate the loss of moisture from the skin, making it dry and tight. Summary of the invention

[0004] The invention aims to provide a traditional Chinese medicine disposable hand sanitizer to solve the problems existing in the existing disposable hand sanitizers.

[0005] The invention provides a traditional Chinese medicine wash-free hand sanitizer, which comprises 0.5% of forsythia essential oil, 0.5% of schizonepeta essential oil, 0.5% of elsholtzia essential oil, 0.7% of cassia twig essential oil, 0.7% of galangal essential oil, 0.7% of bergamot essential oil, 0.4% of gelling agent, 3% of emollient, 0.4% of moisturizing agent, 0.2%-0.6% of pH adjusting agent, 1-2 drops of emulsifier and 92%-92.4% of deionized water.

[0006] The above-mentioned Chinese medicine-free hand sanitizer has Chinese medicine extracts as its main ingredients, which can better penetrate the skin, quickly kill pathogens, and has no damage or irritation to normal skin and mucous membrane tissues.

[0007] Furthermore, the gel is Carbomer 490.

[0008] Furthermore, the emollient is glycerin.

[0009] Furthermore, the moisturizing agent is hyaluronic acid.

[0010] Furthermore, the pH regulator is sodium bicarbonate.

[0011] Furthermore, the emulsifier is Tween 80.

[0012] The present invention also provides a method for preparing a traditional Chinese medicine hand sanitizer, the method comprising:

[0013] Take 0.4% gelling agent and 3% emollient and mix with 60ml deionized water in a 200ml beaker, stir until fully swollen by stirring equipment to form a gel matrix;

[0014] Adding moisturizer to the gel matrix and continuing to stir until uniform;

[0015] Continue to add 0.5% Forsythia suspensa essential oil and 0.5% Nepeta tenuifolia essential oil and stir evenly;

[0016] Add 1-2 drops of emulsifier;

[0017] Add pH regulator to adjust the pH to 6.5-7;

[0018] Add the deionized water to 100 ml, stir evenly, let it stand until the bubbles disappear, and then fill it.

[0019] Furthermore, the stirring device is a magnetic stirrer. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 The present invention is a flowchart of a method for preparing a traditional Chinese medicine hand sanitizer according to an embodiment of the present invention.

[0021] The following specific implementation manner will further illustrate the present invention in conjunction with the above-mentioned drawings. DETAILED DESCRIPTION

[0022] In order to facilitate understanding of the present invention, the present invention will be described more fully below with reference to the relevant drawings. Several embodiments of the present invention are provided in the drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.

[0023] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.

[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items.

[0025] The invention provides a traditional Chinese medicine wash-free hand sanitizer, which comprises 0.5% of forsythia essential oil, 0.5% of schizonepeta essential oil, 0.5% of elsholtzia essential oil, 0.7% of cassia twig essential oil, 0.7% of galangal essential oil, 0.7% of bergamot essential oil, 0.4% of gelling agent, 3% of emollient, 0.4% of moisturizing agent, 0.2%-0.6% of pH adjusting agent, 1-2 drops of emulsifier and 92%-92.4% of deionized water.

[0026] The above-mentioned Chinese medicine-free hand sanitizer has Chinese medicine extracts as its main ingredients, which can better penetrate the skin, quickly kill pathogens, and has no damage or irritation to normal skin and mucous membrane tissues.

[0027] Specifically, Forsythia has the effects of clearing away heat and detoxifying, reducing swelling and dispersing nodules. Its essential oil is rich in a variety of volatile compounds, such as forsythia phenol and forsythia glycosides, which have significant antibacterial activity and have inhibitory and killing effects on a variety of common pathogens such as Staphylococcus aureus and Escherichia coli, and can effectively prevent and control hand infections. Nepeta has the effects of dispelling wind and clearing rashes. The main ingredients in Nepeta essential oil, such as menthone and pulegone, give it good antibacterial and anti-inflammatory properties, which can relieve the inflammatory response of the hand skin, and at the same time inhibit the growth of microorganisms on the surface of the skin, which helps to maintain the health of the hand skin. Elsholtzia can sweat and relieve the surface, eliminate dampness and harmonize the middle. Elsholtzia essential oil contains ingredients such as linalool and limonene, which not only have antibacterial ability, but also can regulate the oil secretion of the skin to a certain extent, keep the skin of the hands fresh, and avoid problems such as dryness and roughness of the skin caused by excessive cleaning or imbalance of oil secretion. Cinnamon twig can sweat and relieve muscles, warm and dredge the meridians. Compounds such as cinnamaldehyde in cassia twig essential oil have strong antibacterial and antiviral activity, which can effectively resist the invasion of various viruses and bacteria, provide a comprehensive protective barrier for the hands, and significantly reduce the risk of hand infection, especially in the high-incidence season of influenza or in an environment with frequent contact with public items. Patchouli has the effects of aromatic turbidity and stopping vomiting. Patchouli essential oil is rich in volatile oil components, such as patchouli alcohol and patchouli ketone. Its unique smell can not only refresh the air, but also has a strong antibacterial and antifungal effect. It has a good inhibitory effect on fungi such as Candida albicans that cause hand skin infections, and can effectively prevent and treat hand fungal infections. Bergamot essential oil has the effects of soothing emotions, antibacterial and anti-inflammatory. Its main ingredients such as limonene and bergamot lactone, in addition to having certain antibacterial activity, can also promote the regeneration and repair of skin cells, improve the texture of hand skin, and make the hand skin more delicate and smooth. At the same time, its pleasant aroma helps to relieve the user's tension and enhance the user experience.

[0028] In the embodiment of the present invention, deionized water is used as a solvent to dissolve and disperse other ingredients to ensure that the ingredients can be fully mixed and function. Deionized water is specially treated to remove impurity ions in the water, thereby avoiding the influence of impurities in the water on product quality and stability, and ensuring the purity and safety of the hand sanitizer.

[0029] In one embodiment of the present invention, the gelling agent is Carbomer 490. Carbomer 490 is a commonly used water-soluble high molecular polymer, and is used as a gelling agent in the present invention. It can form a stable gel matrix, endow the hand sanitizer with good rheological properties, and make it have appropriate viscosity and stability, which is convenient for application and use, and can evenly disperse other ingredients in the system to ensure the quality consistency of the product.

[0030] In one embodiment of the present invention, the emollient is glycerin. Glycerin is an excellent emollient with strong moisturizing properties. It can absorb moisture in the air and keep it on the skin surface, preventing the hand skin from losing water and drying due to cleaning, and keeping the skin soft, smooth and elastic. In addition, glycerin can also promote the skin's absorption of other active ingredients to a certain extent, enhancing the skin care effect of hand sanitizer.

[0031] In one embodiment of the present invention, the moisturizing agent is hyaluronic acid. Hyaluronic acid is a natural moisturizing factor that can form a moisturizing film on the skin surface, lock in moisture, penetrate into the bottom layer of the skin to replenish moisture, increase the water content of the skin, and make the hand skin more hydrated and plump. At the same time, hyaluronic acid also has a certain repair and anti-wrinkle effect, which helps to improve the overall condition of the hand skin.

[0032] In one embodiment of the present invention, the pH adjusting agent is sodium bicarbonate. Sodium bicarbonate is used to adjust the pH value of the hand sanitizer to a weakly acidic range of 6.5-7. This pH range is similar to the pH value of human skin, which can maintain a weakly acidic environment on the surface of the skin and is beneficial to the health of the skin. A weakly acidic environment can inhibit the growth and reproduction of harmful microorganisms, while avoiding irritation and damage to the skin due to excessively high or low pH values, thereby protecting the natural barrier function of the skin.

[0033] In one embodiment of the present invention, the emulsifier is Tween 80. As an emulsifier, Tween 80 can increase the viscosity of the hand sanitizer, making it easier to adhere to the hand surface during use, prolonging the contact time with the skin, thereby improving the sterilization and disinfection effect. At the same time, Tween 80 also has a certain emulsification effect, which helps to evenly disperse oil-soluble traditional Chinese medicine essential oils and other ingredients in the water phase to form a stable emulsion system, thereby ensuring the uniformity and stability of the product.

[0034] The above-mentioned Chinese medicine hand sanitizer also has the following beneficial effects:

[0035] Highly efficient sterilization and disinfection: The various Chinese herbal essential oil ingredients in this Chinese herbal hand sanitizer work synergistically and can quickly penetrate the skin surface. It has a powerful killing effect on common pathogens such as Staphylococcus aureus, Escherichia coli, Candida albicans, etc., and effectively prevents and controls the spread of infectious diseases on the hands.

[0036] Gentle and non-irritating: The main ingredients are all Chinese herbal extracts, which do not cause any damage or irritation to normal skin and mucous membrane tissues. Compared with traditional chemical synthetic antibacterial hand sanitizers, this product is more suitable for long-term use, especially for people with sensitive skin, children, medical staff and other groups who wash their hands frequently. It can protect the health of the hand skin to the greatest extent while ensuring the cleaning effect.

[0037] Moisturizing skin care: The added moisturizing ingredients such as glycerin and hyaluronic acid can provide sufficient moisture and nutrition to the skin while cleaning the hands, prevent the skin from drying and roughness, keep the skin of the hands soft, smooth and elastic, and have good skin care effects.

[0038] Suitable pH value: The pH value is adjusted to the weakly acidic range of 6.5-7 by sodium bicarbonate, which matches the physiological pH value of human skin. It helps to maintain the microecological balance on the skin surface, reduce skin problems caused by pH discomfort, and further enhance the mildness and safety of the product.

[0039] Easy to use: The hand sanitizer does not require water for rinsing, and can be used to clean hands conveniently even when there is no water source. It is suitable for use in various occasions such as going out, traveling, and working, protecting hand hygiene anytime and anywhere.

[0040] See also Figure 1 The present invention also provides a method for preparing a traditional Chinese medicine hand sanitizer, the method comprising:

[0041] Take 0.4% gelling agent and 3% emollient and mix with 60ml deionized water in a 200ml beaker, stir until fully swollen by stirring equipment to form a gel matrix;

[0042] Adding moisturizer to the gel matrix and continuing to stir until uniform;

[0043] Continue to add 0.5% Forsythia suspensa essential oil and 0.5% Nepeta tenuifolia essential oil and stir evenly;

[0044] Add 1-2 drops of emulsifier;

[0045] Add pH regulator to adjust the pH to 6.5-7;

[0046] Add the deionized water to 100 ml, stir evenly, let it stand until the bubbles disappear, and then fill it.

[0047] The above-mentioned method for preparing a Chinese medicine-free hand sanitizer uses Chinese medicine extracts as the main ingredients, which can better penetrate the skin, quickly kill pathogens, and have no damage or irritation to normal skin and mucous membrane tissues. At the same time, the prepared Chinese medicine-free hand sanitizer can maintain good bactericidal and moisturizing effects.

[0048] Specifically, 0.4% of Carbomer 490 and 3% of glycerol and 60ml of deionized water are added to a 200ml beaker and stirred using a magnetic stirrer. Carbomer 490 gradually swells during stirring to form a gel matrix with a certain viscosity. The stirring time is generally controlled at 15-20 minutes to ensure that Carbomer 490 is fully swollen to form a uniform and stable gel structure, providing a good basis for the addition of subsequent components. 0.4% hyaluronic acid is added to the formed gel matrix and continued to be stirred using a magnetic stirrer. The stirring speed is kept moderate, usually 300-500 rpm, and the stirring time is about 10-15 minutes, so that the hyaluronic acid is evenly dispersed in the gel matrix, fully mixed with ingredients such as glycerol, exerts its moisturizing effect, and improves the moisturizing performance of the gel system. Then 0.5% Forsythia suspensa essential oil and 0.5% Nepeta tenuifolia essential oil are added to the above system in sequence and stirred evenly. Since Chinese herbal essential oils have certain volatility and hydrophobicity, attention should be paid to controlling the stirring speed and time during stirring to avoid excessive loss of essential oils due to volatilization. The stirring speed can be controlled at 200-400 rpm, and the stirring time is about 8-12 minutes to ensure that the essential oils are evenly dispersed in the gel system and fully integrated with other ingredients, so that the hand sanitizer has good antibacterial activity. Then add 1-2 drops of Tween 80 as an emulsifier. Tween 80 can increase the viscosity of the system, making it easier to adhere to the surface of the hand when used. The addition should be slow and stirred continuously, with a stirring speed of about 100-300 rpm and a stirring time of about 5-8 minutes to evenly disperse Tween 80 and form a stable emulsion system to ensure the uniformity and stability of the product. Then add sodium bicarbonate to adjust the pH value to 6.5-7. During the addition process, the solution should be added while stirring, and a pH meter should be used to monitor the changes in pH in real time. The stirring speed is maintained at 100-200 rpm. According to the change of pH value, the dripping speed and amount of sodium bicarbonate are carefully controlled to ensure that the pH value is accurately adjusted within the target range, so that the product meets the physiological pH value requirements of human skin and ensures the mildness and safety of the product. Finally, add deionized water to 100ml, continue to stir evenly, and let the solution stand. The stirring time is about 5-10 minutes to further mix the ingredients. The standing time is generally 30-60 minutes. The purpose is to allow the bubbles in the solution to disappear naturally, so as to obtain a Chinese medicine hand sanitizer product with uniform appearance and no bubbles. Then the filling operation can be carried out, and the finished product can be packaged into suitable containers, such as bottles, tubes, etc., for the convenience of consumers.

[0049] It should be noted that the content of various reagents in the above corrections is only the amount used to prepare a batch of Chinese herbal hand sanitizer. During the mass production process, the various sufficient amounts can be adjusted according to the proportion of various ingredients to achieve mass production.

[0050] In order to prove that the Chinese medicine hand sanitizer provided by this application has the corresponding effect, this application also completes the following experiments:

[0051] Antibacterial effect evaluation experiment

[0052] Dilution plate method

[0053] (I) Specific operation steps

[0054] Grouping and preparation: The control group is a bacterial suspension without antibacterial products, and the experimental group is a bacterial suspension containing antibacterial products. Pick a single colony from the standard strain and inoculate it into a liquid culture medium for bacterial enrichment. After reaching an appropriate concentration, use physiological saline to dilute to the required concentration for the experiment. Add 1% of the antibacterial product to the experimental group and mix well.

[0055] Apply bacterial suspension: Take an appropriate amount of bacterial suspension, dip it with a sterile cotton swab, and rotate and press it on the inner wall of the test tube to remove excess bacterial liquid. Apply the cotton swab evenly on the surface of the plate, repeat three times, and rotate the plate about 60° each time to ensure that the bacterial liquid is evenly distributed. Finally, apply it along the edge of the plate to prevent the bacterial liquid from flowing.

[0056] Cultivation and observation: Place the coated plate upside down in a constant temperature incubator and culture at a suitable temperature (such as 37°C) for 24-48 hours until colonies are formed. After the culture is completed, observe and record the growth of the colonies in an ultra-clean workbench or sterile environment.

[0057] (II) Data processing steps

[0058] 1. Colony count: Count the colonies on each plate, and be careful to exclude the interference of contaminating colonies, and only count the colonies of the target microorganisms. When counting, select plates with colony counts between 30 and 300 to improve the counting accuracy.

[0059] 2. Calculate the average colony count: For multiple parallel plates at each dilution, calculate the average colony count to reduce errors.

[0060] 3. Calculate the inhibition rate: Calculate the inhibition rate based on the average colony counts of the control group and the experimental group: Inhibition rate = [(average colony count of the control group - average colony count of the experimental group) / average colony count of the control group] × 100%.

[0061] 4. Result analysis:

[0062] Analyze the calculation results to determine the inhibitory effect of the antibacterial agent on microorganisms.

[0063]

[0064] 3. Skin irritation test

[0065] 1. Drug testing and experimental animals

[0066] 1.1 Drug testing

[0067] Chinese herbal hand sanitizer, blank matrix

[0068] 1.2 Experimental animals

[0069] 12 mice, half male and half female

[0070] 2 Experimental methods

[0071] 2.1 Skin irritation test

[0072] The mice were depilated 24 hours before administration using the mouse skin autologous control method, with the depilation range of 1 cm × 1 cm on each side. The mice were divided into group A and group B, with 6 mice in each group. The left spinal area of ​​group A was the intact skin stimulation experimental area, and the right spinal area was used as the blank control area for intact skin. The left spinal area of ​​group B was the damaged skin stimulation experimental area, and the right spinal area was used as the blank control area for damaged skin.

[0073] Table 1 Rating criteria for skin irritation reactions

[0074]

[0075] 2.1.1 Single-dose skin irritation test

[0076] Three mice were taken from each of the A and B groups, a total of six mice, and treated according to the method in "2.1". 1g of Chinese medicine hand sanitizer was applied to the left test area of ​​the spine, and 1g of blank matrix was applied to the right test area as a control. After the hand sanitizer was completely evaporated, the drug was removed, and the erythema and swelling of the skin, as well as the recovery of these changes, were observed at 1 hour, 24 hours, 48 ​​hours, and 72 hours.

[0077] Table 2 Single skin irritation test results

[0078]

[0079]

[0080] 2.1.2 Repeated administration skin irritation test

[0081] Three mice were taken from each of the A and B groups, for a total of six mice, and the drugs were administered once a day for one week according to the application method in "2.1.1". After each administration, observations were made after the wash-free gel was completely evaporated. After the administration, the drug was removed, and the erythema and swelling at the application site, as well as the recovery of these changes, were observed after 1 hour, 24 hours, 48 ​​hours, and 72 hours.

[0082] Table 3 Results of multiple skin irritation tests

[0083]

[0084] From the above experimental structure, it can be seen that the traditional Chinese medicine hand sanitizer provided by this application does have the following effects:

[0085] Highly efficient sterilization and disinfection: The various Chinese herbal essential oil ingredients in this Chinese herbal hand sanitizer work synergistically and can quickly penetrate the skin surface. It has a powerful killing effect on common pathogens such as Staphylococcus aureus, Escherichia coli, Candida albicans, etc., and effectively prevents and controls the spread of infectious diseases on the hands.

[0086] Gentle and non-irritating: The main ingredients are all Chinese herbal extracts, which do not cause any damage or irritation to normal skin and mucous membrane tissues. Compared with traditional chemical synthetic antibacterial hand sanitizers, this product is more suitable for long-term use, especially for people with sensitive skin, children, medical staff and other groups who wash their hands frequently. It can protect the health of the hand skin to the greatest extent while ensuring the cleaning effect.

[0087] Moisturizing skin care: The added moisturizing ingredients such as glycerin and hyaluronic acid can provide sufficient moisture and nutrition to the skin while cleaning the hands, prevent the skin from drying and roughness, keep the skin of the hands soft, smooth and elastic, and have good skin care effects.

[0088] Suitable pH value: The pH value is adjusted to the weakly acidic range of 6.5-7 by sodium bicarbonate, which matches the physiological pH value of human skin. It helps to maintain the microecological balance on the skin surface, reduce skin problems caused by pH discomfort, and further enhance the mildness and safety of the product.

[0089] Easy to use: The hand sanitizer does not require water for rinsing, and can be used to clean hands conveniently even when there is no water source. It is suitable for use in various occasions such as going out, traveling, and working, protecting hand hygiene anytime and anywhere.

[0090] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A Chinese medicine hand sanitizer, characterized in that: It includes 0.5% Forsythia suspensa essential oil, 0.5% Nepeta tenuifolia essential oil, 0.5% Elsholtzia ciliata essential oil, 0.7% Cassia twig essential oil, 0.7% Hovenia grandiflora essential oil, 0.7% bergamot essential oil, 0.4% gel, 3% emollient, 0.4% moisturizer, 0.2%-0.6% pH adjuster, 1-2 drops of emulsifier, and 92%-92.4% deionized water.

2. The Chinese medicine hand sanitizer according to claim 1, characterized in that: The gel is Carbomer 490.

3. The Chinese medicine hand sanitizer according to claim 1, characterized in that: The emollient is glycerin.

4. The Chinese medicine hand sanitizer according to claim 1, characterized in that: The moisturizing agent is hyaluronic acid.

5. The Chinese medicine hand sanitizer according to claim 1, characterized in that: The pH regulator is sodium bicarbonate.

6. The Chinese medicine hand sanitizer according to claim 1, characterized in that: The emulsifier is Tween 80.

7. A method for preparing a Chinese medicine hand sanitizer, characterized in that: The method comprises: Take 0.4% gelling agent and 3% emollient and mix with 60ml deionized water in a 200ml beaker, stir until fully swollen by stirring equipment to form a gel matrix; Adding moisturizer to the gel matrix and continuing to stir until uniform; Continue to add 0.5% Forsythia suspensa essential oil and 0.5% Nepeta tenuifolia essential oil and stir evenly; Add 1-2 drops of emulsifier; Add pH regulator to adjust the pH to 6.5-7; Add the deionized water to 100 ml, stir evenly, let it stand until the bubbles disappear, and then fill it.

8. The method for preparing the Chinese medicine hand sanitizer according to claim 7, characterized in that: The stirring device is a magnetic stirrer.

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