Preparation process of croton seed cream

Abstract

The invention discloses a preparation technology of croton seed cream, and belongs to the technical field of traditional Chinese medicine decoction piece processing. Comprising the following steps: (1) squeezing croton seed kernels to remove oil, and crushing to obtain croton powder; and (2) detecting the content of fatty oil in croton bean powder, adding starch according to the content of the fatty oil, and uniformly mixing to obtain the croton cream, the addition amount of the starch is equal to the sum of the weight of the croton powder and the content of the fatty oil / 19%-the weight of the croton powder. According to the preparation technology of the croton seed cream, the good extraction effect is achieved, the preparation process of the croton seed cream is accelerated, byproducts are not generated, the whole technological process is safe and non-toxic, the toxicity of the raw materials is reduced, the final product is inspected, the content of fatty oil is 18%-20%, the content of crotonin is 0.89%-0.9%, and the content of the crotonin is 0.89%-0.9%. Various data specified by pharmacopoeia are met, and due effects of the medicine are obtained while the safety of the medicine is ensured.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine preparation, in particular to a preparation process of croton frost. Background Art

[0002] Croton frost, a processed product of croton, is a kind of Chinese medicinal preparation. Croton is distributed in Southwest China, Fujian, Hunan, Hubei, Guangxi, Guangdong and other places. Croton frost is a processed product prepared from croton. The commonly used preparation methods include pressing, extraction, dilution and other methods. The purpose of the processing is to remove the toxicity of croton. The pressing method or dilution method cannot effectively control the removal of croton toxicity during the processing process. The pressing method removes the toxicity through micro-heating and pressing, and the production cycle is long and the oil output is difficult to control. The dilution method directly adds starch, which is easy to produce insufficient crotonin content in the croton frost. Dealing with croton toxicity is the key point in the production of croton frost. Therefore, an effective method is needed to effectively reduce the toxicity of croton frost while retaining the crotonin content and fatty oil content. Summary of the invention

[0003] The purpose of the present invention is to provide a preparation process of croton frost to solve the problems existing in the above-mentioned prior art.

[0004] To achieve the above object, the present invention provides the following solutions:

[0005] One of the technical solutions of the present invention is a process for preparing croton frost, characterized in that it comprises the following steps:

[0006] (1) taking croton seeds, pressing and removing oil, and crushing to obtain croton powder;

[0007] (2) Detect the fatty oil content in croton powder, add starch according to the fatty oil content and mix well to obtain the croton frost; the amount of starch added is:

[0008] The amount of starch added = the weight of croton powder × the content of fatty oil / 19% - the weight of croton powder.

[0009] The second technical solution of the present invention is the croton frost prepared by the preparation process.

[0010] Based on the above technical solution, the present invention has the following technical effects:

[0011] The invention provides a preparation process of croton frost. The method not only has good extraction effect, accelerates the preparation process of croton frost and does not produce by-products, but also the whole process is safe and non-toxic, and the toxicity of the raw materials themselves is reduced. The final product passes the test, and the fatty oil content is 18%-20%, and the croton glycoside content is 0.89%-0.9%, which meets the various data specified in the pharmacopoeia, ensures the safety of the medicine, and obtains the desired effect of the medicine itself. DETAILED DESCRIPTION

[0012] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0013] It should be understood that the terms described in the present invention are only for describing special embodiments and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. Each smaller range between the intermediate value in any stated value or stated range and any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0014] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0015] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention description without departing from the scope or spirit of the present invention. Other embodiments derived from the present invention description will be apparent to those skilled in the art. The present application description and examples are exemplary only.

[0016] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0017] The technical solutions described in the present invention, unless otherwise specified, are all conventional solutions in the art, and the reagents or raw materials used, unless otherwise specified, are purchased from commercial channels or have been disclosed.

[0018] The embodiment of the present invention provides a preparation process of croton frost, comprising the following steps:

[0019] (1) taking croton seeds, pressing and removing oil, and crushing to obtain croton powder;

[0020] (2) Detect the fatty oil content in croton powder, add starch according to the fatty oil content and mix well to obtain the croton frost; the amount of starch added is:

[0021] The amount of starch added = the weight of croton powder × the content of fatty oil / 19% - the weight of croton powder.

[0022] In some specific embodiments, the method of deoiling by pressing is: the method of deoiling by pressing is: deoiling at 100-150°C and 2-3 pressures for 1-3 minutes. The 2-3 are the pressure values ​​of the equipment. The oil press used in the present invention was purchased from Nanjing Kangshan Pharmaceutical Equipment Co., Ltd., with the number SB-DC019.

[0023] In some specific embodiments, the pulverizing time is 40 to 60 seconds.

[0024] The embodiment of the present invention also provides croton cream prepared by the preparation process.

[0025] In some specific embodiments, the fatty oil content in the croton frost is 18% to 20%, and the crotonin content is 0.89% to 0.9%.

[0026] Example 1

[0027] 1. Take the raw materials of croton that have passed the raw material inspection to prepare croton cream.

[0028] 2. Place the raw croton medicinal materials on the sorting table in the cleaning room to remove impurities. After removing the impurities, place them in the peeling machine to remove the skin and take out the clean kernels. The remaining skin residue in the croton kernels is placed on the picking table for manual selection and removal again to obtain the seed kernels (the seed kernels are white or milky white kernels).

[0029] 3. Start the oil press and set the temperature to 100℃. When the temperature reaches the set temperature, put the cleaned croton kernels into the oil press and adjust the pressure appropriately. Press at 100℃ and 2 pressure for 2 minutes to extract the oil. (It is best to press the croton into flakes). Use a clean container to hold the de-oiled croton.

[0030] 4. Load the deoiled croton into a powder grinder in batches (control the amount not to exceed 2 kg each time) and grind it at a speed of 1860 rpm and a grinding time of 40 seconds. Grind it into loose powder with oiliness. Put the croton powder into a clean container and seal it for storage.

[0031] 5. Determine whether to add starch based on the test results of the intermediate product. When the fat oil content is greater than 20%, an appropriate amount of starch needs to be added. When the fat oil content is 18% to 20%, no starch needs to be added.

[0032] The amount of starch added = the weight of croton powder × the content of fatty oil / 19% - the weight of croton powder.

[0033] 6. Put the croton powder and the calculated starch into the mixer in turn and mix them.

[0034] 7. Take the mixed croton cream and conduct a full inspection.

[0035] The test standards are: fatty oil content 18%-20%, crotonin content (C 10 H 13 N5O5) is not less than 0.080%.

[0036] 8. After passing the inspection, the products will be repacked and put into storage.

[0037] Production batch number: D24072601, after production, the test data is: fatty oil 18.9% (standard 18.0%-20.0%); crotonin 0.89% (standard content C 10 H 13 N5O5 not less than 0.080%).

[0038] Example 2

[0039] 1. Take the raw materials of croton that have passed the raw material inspection to prepare croton cream.

[0040] 2. Place the raw croton medicinal materials on the sorting table in the cleaning room to remove impurities. After removing the impurities, place them in the peeling machine to remove the skin and take out the clean kernels. The remaining skin residue in the croton kernels is placed on the picking table for manual selection and removal again to obtain the seed kernels (the seed kernels are white or milky white kernels).

[0041] 3. Start the oil press and set the temperature to 150℃. When the temperature reaches the set temperature, put the cleaned croton kernels into the oil press and adjust the pressure appropriately. Press at 150℃ and 3 pressures for 1 minute to extract the oil. (It is best to press the croton into flakes). Use a clean container to hold the de-oiled croton.

[0042] 4. Load the deoiled croton into a powder grinder in batches (the amount each time should not exceed 2 kg) and grind it at a speed of 1860 rpm and a grinding time of 60 seconds. Grind it into loose powder that meets the requirements and has oiliness. Put the croton powder into a clean container and seal it for storage.

[0043] 5. Determine whether to add starch based on the test results of the intermediate product. When the fat oil content is greater than 20%, an appropriate amount of starch needs to be added. When the fat oil content is 18% to 20%, no starch needs to be added.

[0044] The amount of starch added = the weight of croton powder × the content of fatty oil / 19% - the weight of croton powder.

[0045] 6. Put the croton powder and the calculated starch into the mixer in turn and mix them.

[0046] 7. Take the mixed croton cream and conduct a full inspection.

[0047] The test standards are: fatty oil content 18%-20%, crotonin content (C 10 H 13 N5O5) is not less than 0.080%.

[0048] 8. After passing the inspection, the products will be repacked and put into storage.

[0049] Production batch number: D24072602, after production, the test data is: fatty oil 19.0% (standard 18.0%-20.0%); crotonin 0.90% (standard content C 10 H 13 N5O5 not less than 0.080%).

[0050] Example 3

[0051] 1. Take the raw materials of croton that have passed the raw material inspection to prepare croton cream.

[0052] 2. Place the raw croton medicinal materials on the sorting table in the cleaning room to remove impurities. After removing the impurities, place them in the peeling machine to remove the skin and take out the clean kernels. The remaining skin residue in the croton kernels is placed on the picking table for manual selection and removal again to obtain the seed kernels (the seed kernels are white or milky white kernels).

[0053] 3. Start the oil press and set the temperature to 120℃. When the temperature reaches the set temperature, put the cleaned croton kernels into the oil press and adjust the pressure appropriately. Press at 120℃ and 2 pressure for 3 minutes to extract oil. (It is best to press the croton into flakes). Use a clean container to hold the de-oiled croton.

[0054] 4. Load the deoiled croton into a powder grinder in batches (the amount each time should not exceed 2 kg) and grind it at a speed of 1860 rpm and a grinding time of 50 seconds. Grind it into loose powder that meets the requirements and has oiliness. Put the croton powder into a clean container and seal it for storage.

[0055] 5. Determine whether to add starch based on the test results of the intermediate product. When the fat oil content is greater than 20%, an appropriate amount of starch needs to be added. When the fat oil content is 18% to 20%, no starch needs to be added.

[0056] The amount of starch added = the weight of croton powder × the content of fatty oil / 19% - the weight of croton powder.

[0057] 6. Put the croton powder and the calculated starch into the mixer in turn and mix them.

[0058] 7. Take the mixed croton cream and conduct a full inspection.

[0059] The test standards are: fatty oil content 18%-20%, crotonin content (C 10 H 13 N5O5) is not less than 0.080%.

[0060] 8. After passing the inspection, the products will be repacked and put into storage.

[0061] Raw material fatty oil 23.2%; crotonin 1.06% After workshop processing (frost making), finished product batch number: 24072603, inspection data After production, inspection data fatty oil 18.9% (standard 18.0%-20.0%); crotonin 0.89% (standard content C 10 H 13 N5O5 not less than 0.080%)

[0062] The frosting process reduces the content of fatty oil and crotonin to meet the data requirements of the 2020 edition of the Pharmacopoeia of the People's Republic of China for croton cream, and can be directly used for drug treatment.

[0063] In summary, the present invention provides a croton frost preparation process, by peeling the croton raw medicinal material and squeezing out oil, powdering and mixing, and adding starch to make frost, taking the cleaned croton and putting it into a peeling machine to remove the outer skin to obtain a smooth seed kernel, putting the seed kernel into an oil press to extract oil, taking the powder formed into a cake-shaped thin slice after squeezing and loading it into a powder machine for crushing, taking the crushed coarse powder for detection, adding starch ratio according to the data calculation of the test results (croton glycosides, fatty oil), putting starch and the crushed coarse powder into a mixer and mixing them evenly to form frost, taking the mixed croton frost for full inspection, and packaging it into small packages for storage after passing the inspection. The method of the present invention not only has a good extraction effect, but also speeds up the croton frost preparation process, does not produce by-products, and the entire process is safe and non-toxic, reduces the toxicity of the raw material itself, and the final product passes the inspection, meets the various data specified in the pharmacopoeia, and ensures that the drug safety is obtained while the drug itself should have the effect.

[0064] Obviously, the above embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the implementation methods of the present invention. For ordinary technical users in the relevant field, other different forms of changes or modifications can be made on the basis of the above description. It is not necessary and impossible to list all the implementation methods here. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the claims of the present invention.

Claims

1. A process for preparing croton frost, characterized in that: The following steps are involved: (1) taking croton seeds, pressing and removing oil, and crushing to obtain croton powder; (2) Detect the fatty oil content in croton powder, add starch according to the fatty oil content and mix well to obtain the croton frost; the amount of starch added is: The amount of starch added = the weight of croton powder × the content of fatty oil / 19% - the weight of croton powder.

2. The preparation process according to claim 1, characterized in that: The method for deoiling by squeezing is: deoiling by squeezing at 100-150°C and 2-3 pressures for 1-3 minutes.

3. The preparation process according to claim 1, characterized in that: The duration of the pulverization is 40 to 60 seconds.

4. Croton frost prepared by the preparation process according to any one of claims 1 to 3.

5. The croton cream according to claim 4, characterized in that The fat oil content in the croton frost is 18% to 20%, and the croton glycoside content is 0.89% to 0.9%.