Traditional Chinese medicine composition and application of traditional Chinese medicine composition in preparation of products with antihypertensive effect

Abstract

The invention provides a traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of a product with an antihypertensive effect. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-32 parts of veratrum nigrum, 15-20 parts of pseudo-ginseng, 12-18 parts of corn stigma, 2-5 parts of gastrodia elata, 10-15 parts of folium apocyni veneti, 4-8 parts of aloe, 5-10 parts of American ginseng, 3-12 parts of polygonum multiflorum, 15-22 parts of coreopsis tinctoria, 10-14 parts of tartary buckwheat, 2-7 parts of laver, 1-7 parts of coreopsis tinctoria, 3-6 parts of ginkgo leaves, 5-12 parts of radix achyranthis bidentatae, 8-14 parts of gastrodia elata, 6-11 parts of uncaria, 2-8 parts of fructus evodiae and 10-14 parts of cinnamon. The traditional Chinese medicine composition is good in blood pressure lowering effect, free of side effects and wide in application prospect.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition and an application thereof in preparing a product with a blood pressure lowering effect. Background Art

[0002] Hypertension, also known as high blood pressure, is a chronic disease in which blood pressure in the arteries is abnormally high for a long time. It is a major public health problem worldwide and is closely related to a variety of serious health problems such as heart disease, stroke, and kidney disease. The following is some core information about hypertension. Hypertension is defined as systolic blood pressure ≥140mmHg or diastolic blood pressure ≥90mmHg measured three times on different days without the use of antihypertensive drugs. Classification: Including by age (such as children, adolescents, pregnancy, young and middle-aged, elderly), cause (primary hypertension and secondary hypertension), blood pressure elevation level (grade 1, grade 2, grade 3), etc. Symptoms: Hypertension is sometimes called the "silent killer" because it may have no obvious symptoms, but some people may experience symptoms such as dizziness, headache, fatigue, palpitations, blurred vision, etc. The causes of hypertension are complex, including but not limited to genetic factors, high-salt diet, overweight, lack of exercise, excessive drinking, smoking, long-term stress, kidney disease, certain endocrine diseases, etc. Long-term hypertension can lead to atherosclerosis, especially coronary artery sclerosis, and increase the risk of coronary heart disease. Causes left ventricular hypertrophy, which may develop into heart failure in the long term. Increases the risk of arrhythmia.

[0003] More and more people are suffering from high blood pressure. There are multiple factors behind this phenomenon, mainly including the following aspects: Unhealthy lifestyle: With the development of economy and the improvement of living standards, people's dietary structure has changed, and high-salt, high-fat and high-sugar dietary habits have become common. These unhealthy dietary habits are important factors leading to high blood pressure. At the same time, modern people generally lack sufficient physical exercise, and sedentary lifestyles have led to an increase in overweight and obesity rates, which are all risk factors for high blood pressure. Increased life pressure: Modern society is highly competitive, with high pressure in work and life. Long-term mental tension and stress can lead to endocrine disorders, which in turn affect blood pressure regulation and increase the risk of high blood pressure. Bad living habits: Smoking, excessive drinking and other bad living habits are also causes of high blood pressure. Nicotine and alcohol in tobacco can both cause high blood pressure. Insufficient sleep and irregular work and rest: Staying up late, insomnia, and irregular work and rest time will interfere with normal physiological rhythms and affect the blood pressure regulation mechanism, which may lead to high blood pressure in the long run. Environmental factors: Environmental factors such as environmental pollution and noise may also have an adverse effect on blood pressure. Genetic factors: Although not a direct lifestyle factor, genetic background is also an important risk factor for high blood pressure. People with a family history of hypertension have a relatively higher risk of developing the disease. Younger age trend: The age of onset of hypertension is showing a trend of getting younger, partly because young people ignore health management and do not pay attention to prevention, and the unhealthy lifestyles mentioned above are also common among young people.

[0004] The advantages of Chinese medicine compositions in lowering blood pressure are: Comprehensive conditioning: Chinese medicine compositions often contain a variety of herbal ingredients, which can work synergistically to comprehensively regulate the various pathological links of hypertension, not only lowering blood pressure, but also improving blood circulation, regulating blood lipids, protecting vascular endothelium, and protecting target organs such as the heart and kidneys. Less side effects: Compared with Western medicine, many Chinese medicines have relatively fewer side effects due to their natural sources and multi-target mechanisms of action. In particular, Chinese medicines taken by decoction, brewing, etc. have a more obvious mild conditioning effect on the body and are suitable for long-term use. Improve symptoms: Chinese medicine can not only control blood pressure, but also improve some symptoms associated with hypertension, such as dizziness, headache, insomnia, palpitations, etc., and improve the quality of life of patients. Promote self-recovery ability: Chinese medicine compositions often focus on harmonizing yin and yang, replenishing qi and blood, helping the body to restore its own regulatory function, and improving the body's self-repair ability, thereby achieving the purpose of treating both the symptoms and the root causes. Prevention of complications: Long-term and reasonable use of Chinese medicine compositions can effectively control blood pressure fluctuations and reduce the risk of complications such as cardiovascular and cerebrovascular diseases caused by hypertension. However, the Chinese medicine compositions currently available on the market are not ideal in terms of lowering blood pressure. Summary of the invention

[0005] The purpose of the present invention is to provide a traditional Chinese medicine composition and its application in preparing a product with blood pressure lowering effect.

[0006] In order to achieve the above object, the present invention provides the following technical solutions: A traditional Chinese medicine composition, which is prepared from the following raw materials in parts by weight: 25-32 parts of Veratrum, 15-20 parts of Panax notoginseng, 12-18 parts of Corn Silk, 2-5 parts of Gastrodia elata, 10-15 parts of Apocynum venetum leaves, 4-8 parts of Aloe, 5-10 parts of American ginseng, 3-12 parts of Polygonum multiflorum, 15-22 parts of Snow Chrysanthemum, 10-14 parts of Tartary Buckwheat, 2-7 parts of Laver, 1-7 parts of Ginkgo biloba leaves, 3-6 parts of Ginkgo biloba leaves, 5-12 parts of Achyranthes bidentata, 8-14 parts of Gastrodia elata, 6-11 parts of Uncaria rhynchophylla, 2-8 parts of Evodia rutaecarpa, and 10-14 parts of cinnamon bark.

[0007] Furthermore, the preparation method of the Chinese medicine composition comprises the following steps: (1) Veratrum, Panax notoginseng, corn silk, Gastrodia elata, Apocynum venetum leaf and aloe are mixed, crushed and sieved, 12-15 times the amount of the raw drug in a 65%-70% ethanol aqueous solution are added, reflux extraction is performed for 150-180 minutes, extraction is performed 2-3 times, filtration is performed, and the filtrate is combined to obtain an extract A, which is filtered through a microfiltration membrane, concentrated under reduced pressure, and dried to obtain a Chinese medicine extract A; (2) Mix American ginseng, Polygonum multiflorum, snow chrysanthemum, buckwheat, laver, and blue stone ginseng, and grind them into ultrafine powder to obtain powder B, add saccharomyces cerevisiae to powder B, and continue to add pure water in an amount of 12-15 times the volume of powder B, and aerobically ferment at 30-35° C. for 15-20 hours to obtain a fermentation product; add the fermentation product to a 50-55wt% ethanol aqueous solution in an amount of 10-15 times the volume of the fermentation product, reflux extract 2-4 times, each extraction for 30-40 minutes, and combine to obtain an extract; concentrate the extract, and freeze-dry to obtain a Chinese medicine extract B; (3) Ginkgo biloba leaves, Achyranthes bidentata, Gastrodia elata, Uncaria rhynchophylla, Evodia rutaecarpa and Cinnamomum cassia are mixed, crushed and sieved to obtain powder C, and powder C is subjected to supercritical extraction, firstly extracted at 40-45°C and 30-35MPa for 50-70min to obtain fraction A, and then further extracted at 30-35°C and 20-25MPa for 40-50min to obtain fraction B; then extracted at 20-25°C and 10-15MPa for 10-20min to obtain fraction C; fraction A, fraction B and fraction C are mixed in a mass ratio of 1:1.1-1.5:0.3-0.6 to obtain Chinese medicine extract C; (4) Mix the Chinese herbal extract A, the Chinese herbal extract B, and the Chinese herbal extract C to obtain a Chinese herbal composition.

[0008] Furthermore, Saccharomyces cerevisiae accounts for 2-4% of the mass of powder B.

[0009] Furthermore, the microfiltration membrane is a 0.22 μm microfiltration membrane.

[0010] Furthermore, the powder in step (1) is sieved through a 60-80 mesh sieve.

[0011] Furthermore, in step (2), the ultrafine grinding is performed to a size of 15-20 μm.

[0012] Furthermore, after the pulverization in step (3), the product is sieved through a 30-50 mesh screen.

[0013] Further, the CO2 flow rate of fraction A is prepared at 15-17 L / h.

[0014] Furthermore, the CO2 flow rate of fraction B is prepared at 12-14 L / h.

[0015] Furthermore, the CO2 flow rate of fraction B is prepared at 13-15 L / h.

[0016] The invention provides application of a traditional Chinese medicine composition in preparing a product with blood pressure lowering effect.

[0017] Compared with the prior art, the advantages and beneficial effects of the present invention are as follows: the present invention selects a variety of Chinese medicinal raw materials, divides the Chinese medicinal raw materials into three groups for extraction by different methods, and then mixes the obtained extracts, so that the effective components can be fully extracted, and the various components work synergistically, so that the prepared Chinese medicinal composition has a significant blood pressure lowering effect. DETAILED DESCRIPTION

[0018] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0019] Example 1 The present embodiment provides a traditional Chinese medicine composition, which is prepared from the following raw materials in parts by weight: 28 parts of Veratrum, 18 parts of Panax notoginseng, 15 parts of Corn Silk, 3 parts of Gastrodia elata, 12 parts of Apocynum venetum leaves, 6 parts of Aloe, 8 parts of American ginseng, 9 parts of Polygonum multiflorum, 18 parts of Snow Chrysanthemum, 12 parts of Tartary Buckwheat, 4 parts of Laver, 3 parts of Ginkgo biloba leaves, 5 parts of Ginkgo biloba leaves, 9 parts of Achyranthes bidentata, 10 parts of Gastrodia elata, 9 parts of Uncaria rhynchophylla, 6 parts of Evodia rutaecarpa, and 12 parts of cinnamon.

[0020] The preparation method of the Chinese medicine composition comprises the following steps: (1) Veratrum, Panax notoginseng, corn silk, Gastrodia elata, Apocynum venetum leaf and aloe were mixed, crushed and sieved, 13 times the amount of the raw drug in a 67% ethanol aqueous solution were added, refluxed and extracted for 160 min, extracted 3 times, filtered, and the filtrates were combined to obtain extract A, filtered using a microfiltration membrane, concentrated under reduced pressure, and dried to obtain Chinese medicine extract A; (2) American ginseng, Polygonum multiflorum, snow chrysanthemum, buckwheat, laver, and blue flower stone ginseng are mixed and ultrafinely ground to obtain powder B, and saccharomyces cerevisiae is added to powder B, and pure water 13 times the volume of powder B is added, and aerobic fermentation is carried out at 32°C for 18 hours to obtain a fermentation product; the fermentation product is added to a 52wt% ethanol aqueous solution 13 times the volume of the fermentation product, and reflux extraction is performed 3 times, each extraction time is 35 minutes, and the extract is combined to obtain an extract; the extract is concentrated, and freeze-dried to obtain a Chinese medicine extract B; (3) Ginkgo biloba leaves, Achyranthes bidentata, Gastrodia elata, Uncaria rhynchophylla, Evodia rutaecarpa, and Cinnamomum cassia are mixed, crushed, and sieved to obtain powder C. Powder C is subjected to supercritical extraction, firstly extracted at 42°C and 32MPa for 60min to obtain fraction A, then further extracted at 32°C and 22MPa for 45min to obtain fraction B; then extracted at 22°C and 12MPa for 15min to obtain fraction C; fraction A, fraction B, and fraction C are mixed at a mass ratio of 1:1.3:0.5 to obtain Chinese medicine extract C; (4) Mix the Chinese herbal extract A, the Chinese herbal extract B, and the Chinese herbal extract C to obtain a Chinese herbal composition.

[0021] Saccharomyces cerevisiae accounted for 3% of the mass of powder B.

[0022] The microfiltration membrane is a 0.22 μm microfiltration membrane.

[0023] The powder in step (1) is crushed through a 70-mesh sieve.

[0024] In step (2), the particles are ultrafinely ground to 15 μm.

[0025] After crushing in step (3), pass through a 30-mesh sieve.

[0026] The CO2 flow rate for preparing fraction A was 16 L / h.

[0027] The CO2 flow rate for preparing fraction B was 13 L / h.

[0028] The CO2 flow rate for preparing fraction B was 14 L / h.

[0029] Example 2 The present embodiment provides a traditional Chinese medicine composition, which is prepared from the following raw materials in parts by weight: 25 parts of Veratrum, 15 parts of Panax notoginseng, 12 parts of Corn Silk, 2 parts of Gastrodia elata, 10 parts of Apocynum venetum leaves, 4 parts of Aloe vera, 5 parts of American ginseng, 3 parts of Polygonum multiflorum, 15 parts of Snow Chrysanthemum, 10 parts of Tartary Buckwheat, 2 parts of Laver, 1 part of Ginkgo biloba leaves, 5 parts of Achyranthes bidentata, 8 parts of Gastrodia elata, 6-11 parts of Uncaria rhynchophylla, 2 parts of Evodia rutaecarpa, and 10 parts of cinnamon.

[0030] The preparation method of the Chinese medicine composition comprises the following steps: (1) Veratrum, Panax notoginseng, corn silk, Gastrodia elata, Apocynum venetum leaf and aloe were mixed, crushed and sieved, 12 times the amount of the raw drug in a 65% ethanol aqueous solution were added, refluxed and extracted for 150 minutes, extracted twice, filtered, and the filtrates were combined to obtain extract A, filtered using a microfiltration membrane, concentrated under reduced pressure, and dried to obtain Chinese medicine extract A; (2) American ginseng, Polygonum multiflorum, snow chrysanthemum, buckwheat, laver, and blue flower stone ginseng are mixed and ultrafinely ground to obtain powder B, and saccharomyces cerevisiae is added to powder B, and pure water 12 times the volume of powder B is added, and aerobic fermentation is carried out at 30°C for 15 hours to obtain a fermentation product; the fermentation product is added to a 50wt% ethanol aqueous solution 10 times the volume of the fermentation product, and reflux extraction is performed twice, each extraction time is 30 minutes, and the extract is combined to obtain an extract; the extract is concentrated, and freeze-dried to obtain a Chinese medicine extract B; (3) Ginkgo biloba leaves, Achyranthes bidentata, Gastrodia elata, Uncaria rhynchophylla, Evodia rutaecarpa, and Cinnamomum cassia are mixed, crushed, and sieved to obtain powder C, and powder C is subjected to supercritical extraction, firstly extracted at 40°C and 30MPa for 50 min to obtain fraction A, and then further extracted at 30°C and 20MPa for 40 min to obtain fraction B; then extracted at 20°C and 10MPa for 10 min to obtain fraction C; fraction A, fraction B, and fraction C are mixed at a mass ratio of 1:1.1:0.3 to obtain Chinese medicine extract C; (4) Mix the Chinese herbal extract A, the Chinese herbal extract B, and the Chinese herbal extract C to obtain a Chinese herbal composition.

[0031] Saccharomyces cerevisiae accounted for 2% of the mass of powder B.

[0032] The microfiltration membrane is a 0.22 μm microfiltration membrane.

[0033] The powder in step (1) is crushed through a 60-mesh sieve.

[0034] In step (2), the particles are ultrafinely ground to 15 μm.

[0035] After crushing in step (3), pass through a 30-mesh sieve.

[0036] The CO2 flow rate for preparing fraction A was 15 L / h.

[0037] Fraction B was prepared at a CO2 flow rate of 12 L / h.

[0038] The CO2 flow rate for preparing fraction B was 13 L / h.

[0039] Example 3 The present embodiment provides a traditional Chinese medicine composition, which is prepared from the following raw materials in parts by weight: 32 parts of Veratrum, 20 parts of Panax notoginseng, 18 parts of Corn Silk, 5 parts of Gastrodia elata, 15 parts of Apocynum venetum leaves, 8 parts of Aloe vera, 10 parts of American ginseng, 12 parts of Polygonum multiflorum, 22 parts of Snow Chrysanthemum, 14 parts of Tartary Buckwheat, 7 parts of Porphyra, 7 parts of Ginkgo biloba leaves, 6 parts of Ginkgo biloba leaves, 12 parts of Achyranthes bidentata, 14 parts of Gastrodia elata, 11 parts of Uncaria rhynchophylla, 8 parts of Evodia rutaecarpa, and 14 parts of Cinnamon bark.

[0040] The preparation method of the Chinese medicine composition comprises the following steps: (1) Veratrum, Panax notoginseng, corn silk, Gastrodia elata, Apocynum venetum leaf and aloe were mixed, crushed and sieved, 15 times the amount of the raw drug in a 70% ethanol aqueous solution were added, refluxed and extracted for 180 min, extracted 3 times, filtered, and the filtrate was combined to obtain extract A, filtered using a microfiltration membrane, concentrated under reduced pressure, and dried to obtain Chinese medicine extract A; (2) American ginseng, Polygonum multiflorum, snow chrysanthemum, buckwheat, laver, and blue flower stone ginseng are mixed and ultrafinely ground to obtain powder B, and saccharomyces cerevisiae is added to powder B, and pure water 15 times the volume of powder B is added, and aerobic fermentation is carried out at 35°C for 20 hours to obtain a fermentation product; the fermentation product is added to a 55wt% ethanol aqueous solution 15 times the volume of the fermentation product, and reflux extraction is performed 4 times, each extraction time is 40 minutes, and the extract is combined to obtain an extract; the extract is concentrated, and freeze-dried to obtain a Chinese medicine extract B; (3) Ginkgo biloba leaves, Achyranthes bidentata, Gastrodia elata, Uncaria rhynchophylla, Evodia rutaecarpa, and Cinnamomum cassia are mixed, crushed, and sieved to obtain powder C. Powder C is subjected to supercritical extraction, firstly extracted at 45°C and 35MPa for 70min to obtain fraction A, then further extracted at 35°C and 25MPa for 50min to obtain fraction B; then extracted at 25°C and 15MPa for 20min to obtain fraction C; fraction A, fraction B, and fraction C are mixed at a mass ratio of 1:1.5:0.6 to obtain Chinese medicine extract C; (4) Mix the Chinese herbal extract A, the Chinese herbal extract B, and the Chinese herbal extract C to obtain a Chinese herbal composition.

[0041] Saccharomyces cerevisiae accounted for 4% of the mass of powder B.

[0042] The microfiltration membrane is a 0.22 μm microfiltration membrane.

[0043] The powder in step (1) is crushed through an 80-mesh sieve.

[0044] In step (2), the particles are ultrafinely ground to 20 μm.

[0045] After crushing in step (3), pass through a 50-mesh sieve.

[0046] The CO2 flow rate for preparing fraction A was 17 L / h.

[0047] The CO2 flow rate for preparing fraction B was 14 L / h.

[0048] The CO2 flow rate for preparing fraction B was 15 L / h.

[0049] Comparative Example 1 The difference between this comparative example and Example 1 is that the raw material portions of the Chinese herbal medicine extract A are different.

[0050] A traditional Chinese medicine composition, which is prepared from the following raw materials in parts by weight: 3 parts of Veratrum, 6 parts of Panax notoginseng, 22 parts of Corn Silk, 28 parts of Gastrodia elata, 5 parts of Apocynum venetum leaf, 18 parts of Aloe, 8 parts of American ginseng, 9 parts of Polygonum multiflorum, 18 parts of Snow Chrysanthemum, 12 parts of Tartary Buckwheat, 4 parts of Laver, 3 parts of Ginkgo biloba leaf, 5 parts of Ginkgo biloba leaf, 9 parts of Achyranthes bidentata, 10 parts of Gastrodia elata, 9 parts of Uncaria rhynchophylla, 6 parts of Evodia rutaecarpa, and 12 parts of cinnamon bark.

[0051] The preparation method of the Chinese medicine composition comprises the following steps: (1) Veratrum, Panax notoginseng, corn silk, Gastrodia elata, Apocynum venetum leaf and aloe were mixed, crushed and sieved, 13 times the amount of the raw drug in a 67% ethanol aqueous solution were added, refluxed and extracted for 160 min, extracted 3 times, filtered, and the filtrates were combined to obtain extract A, filtered using a microfiltration membrane, concentrated under reduced pressure, and dried to obtain Chinese medicine extract A; (2) American ginseng, Polygonum multiflorum, snow chrysanthemum, buckwheat, laver, and blue flower stone ginseng are mixed and ultrafinely ground to obtain powder B, and saccharomyces cerevisiae is added to powder B, and pure water 13 times the volume of powder B is added, and aerobic fermentation is carried out at 32°C for 18 hours to obtain a fermentation product; the fermentation product is added to a 52wt% ethanol aqueous solution 13 times the volume of the fermentation product, and reflux extraction is performed 3 times, each extraction time is 35 minutes, and the extract is combined to obtain an extract; the extract is concentrated, and freeze-dried to obtain a Chinese medicine extract B; (3) Ginkgo biloba leaves, Achyranthes bidentata, Gastrodia elata, Uncaria rhynchophylla, Evodia rutaecarpa, and Cinnamomum cassia are mixed, crushed, and sieved to obtain powder C. Powder C is subjected to supercritical extraction, firstly extracted at 42°C and 32MPa for 60min to obtain fraction A, then further extracted at 32°C and 22MPa for 45min to obtain fraction B; then extracted at 22°C and 12MPa for 15min to obtain fraction C; fraction A, fraction B, and fraction C are mixed at a mass ratio of 1:1.3:0.5 to obtain Chinese medicine extract C; (4) Mix the Chinese herbal extract A, the Chinese herbal extract B, and the Chinese herbal extract C to obtain a Chinese herbal composition.

[0052] Saccharomyces cerevisiae accounted for 3% of the mass of powder B.

[0053] The microfiltration membrane is a 0.22 μm microfiltration membrane.

[0054] The powder in step (1) is crushed through a 70-mesh sieve.

[0055] In step (2), the particles are ultrafinely ground to 15 μm.

[0056] After crushing in step (3), pass through a 30-mesh sieve.

[0057] The CO2 flow rate for preparing fraction A was 16 L / h.

[0058] The CO2 flow rate for preparing fraction B was 13 L / h.

[0059] The CO2 flow rate for preparing fraction B was 14 L / h.

[0060] Comparative Example 2 The difference between this comparative example and Example 1 is that the raw material portions of the Chinese herbal medicine extract B are different.

[0061] A traditional Chinese medicine composition, which is prepared from the following raw materials in parts by weight: 28 parts of Veratrum, 18 parts of Panax notoginseng, 15 parts of Corn Silk, 3 parts of Gastrodia elata, 12 parts of Apocynum venetum leaves, 6 parts of Aloe, 18 parts of American ginseng, 3 parts of Polygonum multiflorum, 8 parts of Snow Chrysanthemum, 2 parts of Tartary Buckwheat, 14 parts of Laver, 9 parts of Ginkgo biloba leaves, 5 parts of Ginkgo biloba leaves, 9 parts of Achyranthes bidentata, 10 parts of Gastrodia elata, 9 parts of Uncaria rhynchophylla, 6 parts of Evodia rutaecarpa, and 12 parts of cinnamon.

[0062] The preparation method of the Chinese medicine composition comprises the following steps: (1) Veratrum, Panax notoginseng, corn silk, Gastrodia elata, Apocynum venetum leaf and aloe were mixed, crushed and sieved, 13 times the amount of the raw drug in a 67% ethanol aqueous solution were added, refluxed and extracted for 160 min, extracted 3 times, filtered, and the filtrates were combined to obtain extract A, filtered using a microfiltration membrane, concentrated under reduced pressure, and dried to obtain Chinese medicine extract A; (2) American ginseng, Polygonum multiflorum, snow chrysanthemum, buckwheat, laver, and blue flower stone ginseng are mixed and ultrafinely ground to obtain powder B, and saccharomyces cerevisiae is added to powder B, and pure water 13 times the volume of powder B is added, and aerobic fermentation is carried out at 32°C for 18 hours to obtain a fermentation product; the fermentation product is added to a 52wt% ethanol aqueous solution 13 times the volume of the fermentation product, and reflux extraction is performed 3 times, each extraction time is 35 minutes, and the extract is combined to obtain an extract; the extract is concentrated, and freeze-dried to obtain a Chinese medicine extract B; (3) Ginkgo biloba leaves, Achyranthes bidentata, Gastrodia elata, Uncaria rhynchophylla, Evodia rutaecarpa, and Cinnamomum cassia are mixed, crushed, and sieved to obtain powder C. Powder C is subjected to supercritical extraction, firstly extracted at 42°C and 32MPa for 60min to obtain fraction A, then further extracted at 32°C and 22MPa for 45min to obtain fraction B; then extracted at 22°C and 12MPa for 15min to obtain fraction C; fraction A, fraction B, and fraction C are mixed at a mass ratio of 1:1.3:0.5 to obtain Chinese medicine extract C; (4) Mix the Chinese herbal extract A, the Chinese herbal extract B, and the Chinese herbal extract C to obtain a Chinese herbal composition.

[0063] Saccharomyces cerevisiae accounted for 3% of the mass of powder B.

[0064] The microfiltration membrane is a 0.22 μm microfiltration membrane.

[0065] The powder in step (1) was crushed through a 70-mesh sieve.

[0066] In step (2), the particles are ultrafinely ground to 15 μm.

[0067] After crushing in step (3), pass through a 30-mesh sieve.

[0068] The CO2 flow rate for preparing fraction A was 16 L / h.

[0069] The CO2 flow rate for preparing fraction B was 13 L / h.

[0070] The CO2 flow rate for preparing fraction B was 14 L / h.

[0071] Comparative Example 3 The difference between this comparative example and Example 1 is that the raw material portions of the Chinese herbal medicine extract C are different.

[0072] The present embodiment provides a traditional Chinese medicine composition, which is prepared from the following raw materials in parts by weight: 28 parts of Veratrum, 18 parts of Panax notoginseng, 15 parts of Corn Silk, 3 parts of Gastrodia elata, 12 parts of Apocynum venetum leaves, 6 parts of Aloe, 8 parts of American ginseng, 9 parts of Polygonum multiflorum, 18 parts of Snow Chrysanthemum, 12 parts of Tartary Buckwheat, 4 parts of Laver, 3 parts of Blue Flowered Stone Panax, 15 parts of Ginkgo Biloba Leaves, 2 parts of Achyranthes bidentata, 4 parts of Gastrodia elata, 19 parts of Uncaria rhynchophylla, 12 parts of Evodia rutaecarpa, and 2 parts of Cinnamon Bark.

[0073] The preparation method of the Chinese medicine composition comprises the following steps: (1) Veratrum, Panax notoginseng, corn silk, Gastrodia elata, Apocynum venetum leaf and aloe were mixed, crushed and sieved, 13 times the amount of the raw drug in a 67% ethanol aqueous solution were added, refluxed and extracted for 160 min, extracted 3 times, filtered, and the filtrates were combined to obtain extract A, filtered using a microfiltration membrane, concentrated under reduced pressure, and dried to obtain Chinese medicine extract A; (2) American ginseng, Polygonum multiflorum, snow chrysanthemum, buckwheat, laver, and blue flower stone ginseng are mixed and ultrafinely ground to obtain powder B, and saccharomyces cerevisiae is added to powder B, and pure water 13 times the volume of powder B is added, and aerobic fermentation is carried out at 32°C for 18 hours to obtain a fermentation product; the fermentation product is added to a 52wt% ethanol aqueous solution 13 times the volume of the fermentation product, and reflux extraction is performed 3 times, each extraction time is 35 minutes, and the extract is combined to obtain an extract; the extract is concentrated, and freeze-dried to obtain a Chinese medicine extract B; (3) Ginkgo biloba leaves, Achyranthes bidentata, Gastrodia elata, Uncaria rhynchophylla, Evodia rutaecarpa, and Cinnamomum cassia are mixed, crushed, and sieved to obtain powder C. Powder C is subjected to supercritical extraction, firstly extracted at 42°C and 32MPa for 60min to obtain fraction A, then further extracted at 32°C and 22MPa for 45min to obtain fraction B; then extracted at 22°C and 12MPa for 15min to obtain fraction C; fraction A, fraction B, and fraction C are mixed at a mass ratio of 1:1.3:0.5 to obtain Chinese medicine extract C; (4) Mix the Chinese herbal extract A, the Chinese herbal extract B, and the Chinese herbal extract C to obtain a Chinese herbal composition.

[0074] Saccharomyces cerevisiae accounted for 3% of the mass of powder B.

[0075] The microfiltration membrane is a 0.22 μm microfiltration membrane.

[0076] The powder in step (1) was crushed through a 70-mesh sieve.

[0077] In step (2), the particles are ultrafinely ground to 15 μm.

[0078] After crushing in step (3), pass through a 30-mesh sieve.

[0079] The CO2 flow rate for preparing fraction A was 16 L / h.

[0080] The CO2 flow rate for preparing fraction B was 13 L / h.

[0081] The CO2 flow rate for preparing fraction B was 14 L / h.

[0082] Performance Testing 1. Experimental animals: 80 male SD spontaneously hypertensive rats (randomly divided into 8 groups, 10 rats in each group) were used as the experimental groups of Examples 1 to 3, Comparative Examples 1 to 3 and the model control group; 10 male SD rats were used as the healthy control group.

[0083] 2. Dosage: The dosage of the Chinese medicine composition described in Examples 1 to 3 and Comparative Examples 1 to 3 was 0.4 g / kg. The blood pressure was measured with an RBP-1 sphygmomanometer after one week and two weeks. The healthy control group and the model control group were given equal amounts of distilled water, respectively. The blood pressure was measured with an RBP-1 sphygmomanometer after one week and two weeks. The blood pressure values ​​of the rats before and after the test were compared. The experiment adopted the method of gavage administration. The test results are shown in Table 1, and the units in the table are all mmHg.

[0084] Table 1 Performance test results

[0085] The results show that the Chinese medicine compositions prepared in Examples 1-3 of the present invention have significant blood pressure lowering effects. Comparative Examples 1-3 show that the effects decrease when the composition of the raw materials is changed.

[0086] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition, characterized in that: The Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-32 parts of Veratrum, 15-20 parts of Panax notoginseng, 12-18 parts of Corn Silk, 2-5 parts of Gastrodia elata, 10-15 parts of Apocynum venetum leaves, 4-8 parts of Aloe vera, 5-10 parts of American ginseng, 3-12 parts of Polygonum multiflorum, 15-22 parts of Snow Chrysanthemum, 10-14 parts of Tartary Buckwheat, 2-7 parts of Laver, 1-7 parts of Ginkgo biloba leaves, 3-6 parts of Ginkgo biloba leaves, 5-12 parts of Achyranthes bidentata, 8-14 parts of Gastrodia elata, 6-11 parts of Uncaria rhynchophylla, 2-8 parts of Evodia rutaecarpa, and 10-14 parts of cinnamon bark.

2. The Chinese medicine composition according to claim 1, characterized in that The preparation method of the Chinese medicine composition comprises the following steps: (1) Veratrum, Panax notoginseng, corn silk, Gastrodia elata, Apocynum venetum leaf and aloe are mixed, crushed and sieved, 12-15 times the amount of the raw drug in a 65%-70% ethanol aqueous solution are added, reflux extraction is performed for 150-180 minutes, extraction is performed 2-3 times, filtration is performed, and the filtrate is combined to obtain an extract A, which is filtered through a microfiltration membrane, concentrated under reduced pressure, and dried to obtain a Chinese medicine extract A; (2) Mix American ginseng, Polygonum multiflorum, snow chrysanthemum, buckwheat, laver, and blue stone ginseng, and grind them into ultrafine powder to obtain powder B, add saccharomyces cerevisiae to powder B, and continue to add pure water in an amount of 12-15 times the volume of powder B, and aerobically ferment at 30-35° C. for 15-20 hours to obtain a fermentation product; add the fermentation product to a 50-55wt% ethanol aqueous solution in an amount of 10-15 times the volume of the fermentation product, reflux extract 2-4 times, each extraction for 30-40 minutes, and combine to obtain an extract; concentrate the extract, and freeze-dry to obtain a Chinese medicine extract B; (3) Ginkgo biloba leaves, Achyranthes bidentata, Gastrodia elata, Uncaria rhynchophylla, Evodia rutaecarpa and Cinnamomum cassia are mixed, crushed and sieved to obtain powder C, and powder C is subjected to supercritical extraction, firstly extracted at 40-45°C and 30-35MPa for 50-70min to obtain fraction A, and then further extracted at 30-35°C and 20-25MPa for 40-50min to obtain fraction B; then extracted at 20-25°C and 10-15MPa for 10-20min to obtain fraction C; fraction A, fraction B and fraction C are mixed in a mass ratio of 1:1.1-1.5:0.3-0.6 to obtain Chinese medicine extract C; (4) Mix the Chinese herbal extract A, the Chinese herbal extract B, and the Chinese herbal extract C to obtain a Chinese herbal composition.

3. The Chinese medicine composition according to claim 1, characterized in that Saccharomyces cerevisiae accounts for 2-4% of the mass of powder B.

4. The Chinese medicine composition according to claim 1, characterized in that The powder in step (1) is crushed through a 60-80 mesh sieve.

5. The Chinese medicine composition according to claim 1, characterized in that: In step (2), the particles are ultrafinely ground to 15-20 μm.

6. The Chinese medicine composition according to claim 1, characterized in that: After crushing in step (3), pass through a 30-50 mesh sieve.

7. The Chinese medicine composition according to claim 1, characterized in that: The CO2 flow rate for preparing fraction A is 15-17 L / h.

8. The Chinese medicine composition according to claim 1, characterized in that: The CO2 flow rate for preparing fraction B is 12-14 L / h.

9. The Chinese medicine composition according to claim 1, characterized in that: The CO2 flow rate for preparing fraction B is 13-15 L / h.

10. Use of the Chinese medicine composition according to any one of claims 1 to 9 in the preparation of a product having a blood pressure lowering effect.

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