External traditional Chinese medicine compound gel for treating joint swelling and pain and preparation process thereof

Abstract

The invention discloses external traditional Chinese medicine compound gel for treating joint swelling and pain and a preparation process thereof, and belongs to the field of traditional Chinese medicines. The invention discloses external traditional Chinese medicine compound gel for treating joint swelling and pain. The external traditional Chinese medicine compound gel is prepared from the following raw materials: 10-20 parts of radix aconiti preparata, 10-20 parts of radix aconiti kusnezoffii preparata, 10-20 parts of zaocys dhumnade, 10-20 parts of fructus mume and 20-40 parts of rhizoma corydalis. The five traditional Chinese medicines in the weight ratio are subjected to water extraction and prepared according to a gel dosage form to obtain the gel of the medicine, the gel is externally applied to an affected part, and the gel has the effects of treating rheumatoid arthritis, rheumatic arthritis, osteoarthritis and other arthritis with cold-dampness stasis collateral syndromes such as joint swelling and pain, unfavorable flexion and extension, intolerance of cold and cold limbs, dysfunction of activity and the like. The medicine has the curative effects of dispelling cold and dampness, clearing and activating the channels and collaterals and relieving swelling and pain, and is good in safety.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine, and in particular to an external Chinese medicine compound gel for treating joint swelling and pain and a preparation process thereof. Background Art

[0002] Rheumatoid arthritis, rheumatic arthritis, osteoarthritis and other arthritis with cold-dampness and blood stasis belong to the category of "bi syndrome" in traditional Chinese medicine. The main symptoms are joint swelling and pain, poor flexion and extension, fear of cold and cold limbs, and functional impairment, which affect the patient's life and work. As a common disease, bi syndrome has been clearly understood as early as the pre-Qin period. In ancient times, the word "bi" was only used to describe symptoms. The word was used to describe the shape of the limbs, which referred to poor flexion and extension. "Suwen Bi Lun" is the earliest monograph on bi syndrome discovered so far. It records: "The three qi of wind, cold and dampness are mixed together and form bi. The wind qi prevails and it is called walking bi, the cold qi prevails and it is called painful bi, and the damp qi prevails and it is called fixed bi." Rheumatoid arthritis, etc., are called "wengbi" by modern doctors. The etiology of this disease is mainly believed to be divided into two categories: external and internal. The external causes are mainly "wind, cold, dampness, heat, and poison" and other external evil invasions, while the internal causes include deficiency of Yingwei Qi and blood. It is generally caused by the lack of or deficiency of the body's positive energy, the loss of defense, and the influence of wind, cold, dampness, heat and other external evils, which block the tendons, bones and muscles. The internal and external factors interact with each other. In the early stage, the pathogenesis is mainly due to the evil, which is mostly caused by the invasion of the skin and meridians by the external evil; in the middle stage, it is mostly a mixture of deficiency and excess, with qi and blood blocking the meridians and the body being weak; in the middle and late stages, it is mostly phlegm and dampness, and blood stasis blocking the flow of blood into the joints, which is generally a deficiency of the root and excess of the superficial. In terms of treatment, it is generally advocated to treat it according to syndrome differentiation.

[0003] Traditional Chinese medicine has good clinical efficacy, and external treatment is particularly unique and advantageous. There are many Chinese medicine compositions for treating rheumatoid arthritis, rheumatic arthritis, degenerative arthritis, etc., but they all have more or less disadvantages, such as too many medicinal flavors, difficult to obtain materials, expensive prices; unclear efficacy, poor therapeutic effect, etc. Therefore, there is an urgent need for an external Chinese medicine composition for treating joint swelling and pain caused by arthritis. Summary of the invention

[0004] In view of the problems existing in the prior art, the object of the present invention is to provide an external Chinese medicine compound gel for treating joint swelling and pain and a preparation process thereof. The Chinese medicine compound gel disclosed in the present invention has the effects of dispelling cold and dampness, promoting blood circulation and activating collaterals, reducing swelling and relieving pain, and is safe and non-irritating to the skin.

[0005] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions.

[0006] The invention discloses a traditional Chinese medicine composition for treating joint swelling and pain caused by cold-dampness and blood stasis arthritis such as rheumatoid arthritis, rheumatic arthritis and osteoarthritis. The composition is characterized in that the composition is prepared from the following raw materials in weight proportion: 10-20 parts of processed Chuanwu, 10-20 parts of processed Kusnezoffii, 10-20 parts of Agkistrodon aconitifolia, 10-20 parts of Prunus mume and 20-40 parts of Corydalis yanhusuo.

[0007] Furthermore, the composition also includes pharmaceutically acceptable excipients or auxiliary ingredients.

[0008] Furthermore, the above-mentioned Chinese medicine composition is used in the preparation of medicines for treating joint swelling and pain.

[0009] The present invention also discloses a method for preparing a gel preparation of the above-mentioned traditional Chinese medicine composition for joint swelling and pain, which is characterized in that it comprises the following steps: (1) Take 10-20 parts of processed Chuanwu, 10-20 parts of processed Caowu, 10-20 parts of black-striped snake, 10-20 parts of black plum, 20-40 parts of Corydalis, add water to the five-flavor slices and boil them. For the first time, add 10 times the total weight of the slices of Chinese medicine to soak for 1 hour, boil for 1 hour, and filter; for the second time, add 8 times the wet weight of the slices of Chinese medicine to boil for 1 hour, and filter. Combine the filtrates, let stand overnight, take the supernatant and concentrate it to about 500 mL, filter it, and use it as extract A; (2) Take 10g of Carbomer Type B (Type 934), add 200mL of purified water, and soak for 48 hours. Add 15g of triethanolamine and 75g of purified water, stir evenly to form gel B; (3) Take 1 g of ethyl paraben, add 100 mL of ethanol and 50 mL of glycerol, stir and dissolve to obtain solution C; (4) Add the extract A obtained in (1) and the solution C obtained in (3) to the gel B obtained in (2), add purified water to 1000 g, stir, and mix evenly to obtain the gel preparation.

[0010] The invention also discloses a Chinese medicine composition for treating joint swelling and pain, which is characterized in that the composition is prepared from the following raw materials in weight ratio: 10-20 parts of processed Chuanwu, 10-20 parts of processed Kusnezoffii, 10-20 parts of Agkistrodon aconitifolia, 10-20 parts of Prunus mume, and 20-40 parts of Corydalis yanhusuo.

[0011] Furthermore, the above-mentioned Chinese medicine composition is used in the preparation of medicines for treating joint swelling and pain.

[0012] In the drug prescription of the present invention, processed Chuanwu and processed Caowu are processed products of Chuanwu and Caowu, which are pungent, bitter, hot in nature, and have certain toxicity. After processing, the toxicity is reduced. They are the key medicines for dispelling wind and dampness, warming the meridians and relieving pain, and are especially good at relieving pain. They can be used for wind-cold dampness arthralgia, joint cold pain, cold hernia pain and anesthesia and pain relief. "Zhenzhu Nang Buyi Yaoxing Fu" states that Chuanwu "has two uses: dispersing the cold evil of wind and breaking the cold pain of accumulation." Black-tailed snake is sweet in taste and flat in nature. It can dispel rheumatism, dredge the meridians, and stop spasm. It is mainly used to treat rheumatism, numbness of the skin, and cramps of tendons and veins. Black plum is sour and astringent in taste and flat in nature. "Ben Cao Jing Shu" discusses that black plum "is mainly used for limb pain, hemiplegia and numbness, because moisture is soaked in the meridians, the tendons and veins are relaxed, or the pain is numb; the liver governs the tendons, and acid enters the liver to nourish the tendons. The liver is nourished, then the bones are straight and the tendons are soft, the organs are smooth and the previous symptoms are eliminated." Yanhusuo is pungent, bitter, warm, and can promote blood circulation, promote qi, and relieve pain. It is mainly used to treat chest and flank pain, abdominal pain, chest pain, amenorrhea, dysmenorrhea, and swelling and pain caused by falls. This prescription is effective and safe for rheumatoid arthritis, rheumatic arthritis, osteoarthritis, and other arthritis with cold-dampness and blood stasis syndrome, with symptoms such as joint swelling and pain, poor flexion and extension, fear of cold and cold limbs, and functional impairment of movement.

[0013] The compatibility relationship of the pharmaceutical composition of the present invention is: The main drugs are processed Chuanwu and Caowu, which mainly dispel wind and dampness, warm the meridians and relieve pain; the assistant drug is black-striped snake, which assists the main drug in dispelling rheumatism, unblocking meridians and stopping spasms; the adjuvant drug is Corydalis, which assists the main and assistant drugs in strengthening the analgesic effect; the guiding drug is Wumei, which can straighten bones and soften tendons and treat limb pain. The five drugs work together to dispel cold and dampness, unblock meridians and activate collaterals, and reduce swelling and relieve pain.

[0014] Compared with the prior art, the beneficial effects of the present invention are as follows.

[0015] The medicine of the present invention has the effects of dispelling cold and dampness, promoting blood circulation and activating collaterals, reducing swelling and relieving pain, and has good safety and is non-irritating to the skin. The external Chinese medicine compound gel is used to treat rheumatoid arthritis, rheumatic arthritis, osteoarthritis and other arthritis with cold-dampness and blood stasis syndromes with joint swelling and pain as the main symptoms. The medicine of the present invention is applied externally to massage the lesion site, so that the medicine is directly absorbed through the skin, forming a higher local drug concentration, and can be retained for a certain time, so as to better exert the therapeutic effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 Comparison chart between the model group and the normal group.

[0017] Figure 2 For self-control: the left hind limb is the model group, and the right hind limb is the model+Siwu group.

[0018] Figure 3 For self-control: the left hind limb is the model group, and the right hind limb is the model + pepper group. DETAILED DESCRIPTION

[0019] The present invention is further described in detail below with specific embodiments, but it should not be understood that the scope of the above subject matter of the present invention is limited to the following embodiments, and all technologies realized based on the content of the present invention belong to the scope of the present invention.

[0020] Unless otherwise specified, all reagents and materials used in the present invention are commercially available.

[0021] Example 1 [Preparation of the Chinese medicine prescription of the present invention].

[0022] 1. The dosage of the drug formulation of the present invention has good therapeutic effect in the following weight range: 10-20 parts of processed Chuanwu, 10-20 parts of processed Caowu, 10-20 parts of Agkistrodon aconitifolia, 10-20 parts of Prunus mume, and 20-40 parts of Corydalis yanhusuo.

[0023] 2. The drug formulation of the present invention (Siwu Xiaobi Gel) is a Chinese medicine gel for external use, and its preparation method: (1) Take 20g of processed Chuanwu, 20g of processed Caowu, 20g of Agkistrodon acutus, 20g of Prunus mume, and 20g of Corydalis yanhusuo, add water and boil the five-flavor slices. For the first time, add 10 times the total weight of the slices of Chinese medicine to soak for 1 hour, boil for 1 hour, and filter; for the second time, add 8 times the wet weight of the slices of Chinese medicine to boil for 1 hour, and filter. Combine the filtrates, let stand overnight, take the supernatant and concentrate it to about 500 mL, filter it, and use it as extract A; (2) Take 10g of Carbomer Type B (Type 934), add 200mL of purified water, and soak for 48 hours. Add 15g of triethanolamine and 75g of purified water, stir evenly to form gel B; (3) Take 1 g of ethyl paraben, add 100 mL of ethanol and 50 mL of glycerol, stir and dissolve to obtain solution C; (4) Add the extract A obtained in (1) and the solution C obtained in (3) to the gel B obtained in (2), add purified water to 1000 g, stir and mix evenly to obtain Siwu Xiaobi gel.

[0024] Example 2 [Animal pharmacodynamics experiment].

[0025] 1. Materials and methods.

[0026] 1.1 Experimental Animals

[0027] Wistar rats, female, SPF grade, weighing 180±10g, 40 rats.

[0028] Purchased from Benxi Changsheng Biotechnology Co., Ltd.

[0029] 1.2 Experimental drugs and control drugs.

[0030] Name of experimental drug: The patented formula of the present invention (named Siwu Xiaobi Gel) was used to obtain the experimental drug according to the preparation method described in Example 1, and subsequent experiments were carried out.

[0031] Positive control drug: Pepper rheumatism gel (National Medicine Standard Z20050152, Anhui Lerantang Pharmaceutical Co., Ltd.) has the effects of dispelling wind and cold, relaxing muscles and tendons, reducing swelling and relieving pain. It is mainly used to treat joint pain, back pain, sprains, chronic arthritis, unbroken frostbite, etc. For external use, apply to the affected area 2-3 times a day.

[0032] 1.3 Main reagents and instruments used in the experiment.

[0033] Main reagents: Complete Freund's adjuvant (CFA): specification 10 mL / tube, produced by Sigma, batch number: 20130911. Rat ELISA detection kit: Shanghai AMEKO Company, batch number: IL-1β, TNF-α (201403), IL-10 (201407).

[0034] Main instruments and equipment: YLS-7B toe volume meter (Jinan Yiyan), TGL20M-II desktop centrifuge (Hunan Kaida), Neofuge 13R desktop high-speed refrigerated centrifuge (Heal Force), RB-200 intelligent hot plate instrument (Chengdu Taisu), CK1000 tissue grinder (Thmorgan), iMARK absorbance microplate reader (BIO-RAD), paraffin slicer (LEICA), BX51 microscope (OLYMPUS), digital imaging system DR (DAESUNG, South Korea).

[0035] 2 Experimental methods.

[0036] 2.1 Animal husbandry.

[0037] Rearing environment: Experimental Animal Center of Liaoning University of Traditional Chinese Medicine, SPF grade, daily light, room temperature 20-22℃, humidity 26-40%. Each rat was fed 20g / d of feed, and the amount of drinking water was unlimited.

[0038] 2.2 Animal model replication.

[0039] After the rats were adaptively raised for 3 days, the model was established. Model establishment method: First, the sole of the foot was routinely disinfected, and 0.1 mL of CFA was injected into the left and right hind paws of the rats with a 1 mL syringe to cause a local inflammatory reaction. About 7 days later, the hind paws of the rats showed obvious redness and swelling, and the ankles, knees and other non-injection joints were swollen, and the movement was limited, which was considered a successful model.

[0040] 2.3 Animal grouping and dosing.

[0041] The rats with successful modeling were taken and stratified by body weight and randomly divided into 4 groups: a normal group, a model group, a positive drug control group (capsicum rheumatism gel, referred to as the capsicum group), and the Siwu Xiaobi gel of the present invention (referred to as the Siwu group), with 10 rats in each group.

[0042] Except for the normal group, the other groups were given external application to the affected area, twice a day, 3 times each time: the model group was given external application of gel, the positive drug control group was given external application of pepper rheumatism gel, and the Siwu group was given external application of Siwu Xiaobi gel. After 8 days of administration, relevant indicators were measured, the metatarsal joints were taken after being sacrificed, fixed with 4% paraformaldehyde for 2 days, decalcified with 10% EDTA for 4 weeks, and then sectioned with paraffin and stained with HE.

[0043] 3. Indicator detection.

[0044] 3.1 Observation of foot swelling.

[0045] The foot volume measuring instrument (model YSL-7B, Jinan Yiyan) was used to measure the foot volume of each rat before modeling, recorded as V0, and the foot volume was measured at different time points after injection of inflammation, recorded as Vt. The swelling degree was calculated according to the formula ER (%) = (Vt-V0) / V0 × 100%, and the average value of the left and right soles of each rat was taken for calculation, and the changes in swelling degree of each group at different time points were observed.

[0046] 3.2 Hot plate pain stimulation threshold detection.

[0047] Intelligent hot plate instrument, model: RB-200, Chengdu Taimeng Technology Co., Ltd. Preheat the intelligent hot plate instrument and adjust the temperature to 50±0.1℃. Place the rat on the preheated metal plate. While placing the animal, press the "Start / Stop" button. The system automatically starts timing. After observing the rat licking its hind feet, step on the foot switch or press the "Start / Stop" button again. The timing ends and the obtained time is the rat's hot plate pain threshold. Measure again after an interval of 5 minutes. Take the average of the two measurements, which is the measured hot plate pain threshold.

[0048] 3.3 Testing of the pain threshold.

[0049] Electronic tenderness meter, model: YLS-3E, Jinan Yiyan Technology Development Co., Ltd. Use the pointed head of the tenderness meter to apply pressure to the dorsum of the rat's bilateral hind feet. When the rat cries or struggles due to pain, the pressure value displayed is its tenderness threshold.

[0050] 3.4 Detection of inflammatory factors: serum IL-6, TNF-α, and CRP.

[0051] Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) were detected by enzyme-linked immunosorbent assay (Elasa method).

[0052] 3.5 Morphological characteristics of rats in each group.

[0053] photo.

[0054] 4. Statistical analysis.

[0055] SPSS27 statistical software was used for statistical analysis. Numerical variables were expressed as mean ± standard deviation ( ). One-way ANOVA was used to compare the data between multiple groups. P < 0.05 was considered statistically significant.

[0056] 5 Results and analysis

[0057] 5.1 Results of foot swelling values ​​of rats in each group.

[0058] As shown in Table 1, compared with the normal group, the model group had more severe foot swelling, with significant difference (P < 0.01), indicating that the model was successful; compared with the model group, the pepper group and the four-black group had reduced foot swelling, with significant difference (P < 0.01), which effectively improved the degree of foot swelling in rats; there was no significant difference between the pepper group and the four-black group ( P> 0.05).

[0059] Table 1. Results of foot swelling in rats in each group ( , n=10) Note: Compared with the normal group: * P <0.05, ** P <0.01; compared with the model group: △ P <0.05, △△ P <0.01.

[0060] 5.2 Hot plate pain threshold measurement results of rats in each group.

[0061] The hot plate pain threshold represents the degree of pain tolerance. The results of a study by Arora R et al. showed that the hot plate pain threshold of rats with adjuvant arthritis was significantly lower than that of normal rats. [1] . This is consistent with the results of this experiment. As shown in Table 2, compared with the normal group, the pain tolerance time of the model group was shorter, with significant difference (P < 0.01), indicating that the model was successful; compared with the model group, the heat tolerance time of the Siwu group was longer, with significant difference (P < 0.01), which effectively improved the pain sensation of the rats' soles; but there was no significant difference between the pepper group and the Siwu group ( P> 0.05).

[0062] Table 2. Hot plate pain threshold results of rats in each group ( , n=10) Note: Compared with the normal group: * P <0.05, ** P <0.01; compared with the model group: △ P <0.05, △△ P <0.01.

[0063] 5.3 Results of tenderness pain threshold of rats in each group.

[0064] The tenderness threshold has the same meaning as the hot plate pain threshold and is related to the degree of pain tolerance. As shown in Table 3, compared with the normal group, the tenderness threshold of the model group decreased, with significant difference (P < 0.01), indicating that the model was successfully established; compared with the model group, the tenderness threshold of the pepper group and the four-black group increased, with significant difference (P < 0.01), effectively improving the pain in the dorsum of the rat foot; there was no statistically significant difference between the two drug groups ( P> 0.05).

[0065] Table 3. Results of tenderness pain threshold of rats in each group ( , n=10) Note: Compared with the normal group: *P<0.05, **P<0.01; compared with the model group: △P<0.05, △△P<0.01.

[0066] 5.4 Results of serum inflammatory factors IL-6, TNF-α, and CRP levels in rats of each group.

[0067] Interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) are all cytokines related to inflammation.

[0068] IL-6: Compared with the normal group, the model group was significantly increased ( P <0.01), which was statistically significant; compared with the model group, the pepper group significantly reduced ( P <0.01, the four-black group significantly decreased ( P <0.05), which was statistically significant; compared with the pepper group, the four-black group had no significant difference ( P> 0.05).

[0069] TNF-α: Compared with the normal group, the model group was significantly increased ( P<0.01), which was statistically significant; compared with the model group, there was no significant difference in the pepper group ( P >0.05, the four-black group significantly reduced ( P <0.05), the difference was significant; compared with the pepper group, the four black group had no significant difference ( P >0.05).

[0070] CRP: Compared with the normal group, the model group was significantly increased ( P <0.01), which was statistically significant; compared with the model group, the pepper group and the four-black group were slightly reduced, but the difference was not significant ( P >0.05); compared with the pepper group, the four-black group had no significant difference ( P >0.05).

[0071] Table 4. Serum IL-6, TNF-α, and CRP levels in rats of each group ( , n=10) Note: Compared with the normal group, *P<0.05, **P<0.01; compared with the model group, △P<0.05, △△P<0.01; Compared with the chili pepper group, #P<0.05, ##P<0.01.

[0072] 5.5 Morphological characteristics of rats in each group.

[0073] 5.5.1 Morphology (what the naked eye sees).

[0074] Compared with the normal group, the foot and toe joints in the model group were swollen and cyanotic ( Figure 1 ); Compared with the model group, the swelling of the foot and toe joints in the experimental group and the control group was reduced, and the cyanosis became lighter ( Figure 2 , 3 ).

[0075] Example 3 [Clinical efficacy case of external use on human body].

[0076] Ji, female, 38 years old, an employee of a company. Suffering from rheumatoid arthritis for many years, the knee, ankle, elbow and other joints have been greatly improved after treatment, only the right finger joints are swollen and painful, morning stiffness, joints are slightly deformed, and flexion and extension are difficult. Diet and defecation are normal, and sleep is good. The tongue is light red with little coating, and the pulse is slow. Stop taking oral medication and give Siwu Xiaobi Gel (prepared according to the preparation method described in Example 1) for treatment. Apply it to the affected part for external use, three times a day. After 2 weeks of medication, the swelling and pain are relieved, the morning stiffness disappears, and the flexion and extension are improved. There is no obvious effect on joint deformation. After that, it is used for 2 weeks, the swelling and pain disappear, and the flexion and extension are significantly improved.

[0077] Zhang, female, 56 years old, farmer. Suffering from rheumatoid arthritis for 3 years, joint pain all over the body, morning stiffness, swelling and pain in both finger joints and knee joints, poor flexion and extension, likes warmth and fears coldness, often takes painkillers, stomach discomfort, acid reflux, loose stools, and general sleep. The tongue is pale red and greasy with white fur, and the pulse is stringy and slow. Oral treatment with Chinese medicine for warming the liver and kidney, dispelling wind and dampness, and relieving numbness and activating collaterals is given; at the same time, the four black anti-bi gel (prepared according to the preparation method described in Example 1) is applied externally. Apply to the affected part three times a day. After 2 weeks of medication, the swelling and pain are relieved. After 2 weeks of continuous use, the finger joints and knee joints are swollen and the pain is relieved. Because rheumatoid arthritis is a kind of paralysis, the course of disease is long and it is difficult to heal. However, the patient has this Chinese medicine for external use, so he does not need to take oral analgesics, which reduces the stimulation to the stomach. It is cheap and easy to use, so he often comes to the hospital to get medicine, and the self-reported analgesic and swelling effect is very good. Her husband suffered from ankylosing spondylitis and had obvious lower back pain. He applied Siwu Xiaobi Gel on his own and unexpectedly achieved good pain-relieving effects.

[0078] The above description is only a preferred embodiment of the present invention and is not intended to limit the scope of the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating joint swelling and pain, characterized in that: The invention is prepared from the following raw materials in weight proportion: 10-20 parts of processed Chuanwu, 10-20 parts of processed Caowu, 10-20 parts of Zygophyllum dactylum, 10-20 parts of Prunus mume and 20-40 parts of Corydalis yanhusuo.

2. The Chinese medicine composition for joint swelling and pain according to claim 1, characterized in that: The composition also includes pharmaceutically acceptable excipients or auxiliary ingredients.

3. Use of the Chinese medicine composition according to any one of claims 1 to 2 in the preparation of a medicament for treating joint swelling and pain.

4. A method for preparing a gel preparation of the Chinese medicine composition for treating joint swelling and pain according to claim 1, characterized in that: It includes the following steps: (1) Take the five-flavor slices of Chuanwu, Caowu, Wushaoshe, Wumei, and Yanhusuo and add water to boil. For the first time, add 10 times the total weight of the slices of Chinese medicine water to soak for 1 hour, boil for 1 hour, and filter; for the second time, add 8 times the wet weight of the slices of Chinese medicine water, boil for 1 hour, and filter; combine the filtrates, let stand overnight, take the supernatant and concentrate it to about 500 mL, filter, and use it as extract A; (2) Take 10 g of Carbomer Type B (Type 934), add 200 mL of purified water, and soak for 48 hours; add 15 g of triethanolamine and 75 g of purified water, stir evenly to form gel B; (3) Take 1 g of ethyl paraben, add 100 mL of ethanol and 50 mL of glycerol, stir and dissolve to obtain solution C; (4) Add the extract A obtained in (1) and the solution C obtained in (3) to the gel B obtained in (2), add purified water to 1000 g, stir, and mix evenly to obtain the gel preparation.

5. The preparation method according to claim 4, characterized in that: The weight fractions of the drugs in (1) are 10-20 parts of Chuanwu, 10-20 parts of processed Caowu, 10-20 parts of Ulmus pumila, 10-20 parts of Prunus mume, and 20-40 parts of Corydalis yanhusuo.

6. A Chinese medicine composition for treating joint swelling and pain caused by rheumatoid arthritis, rheumatic arthritis, osteoarthritis and cold-dampness and blood stasis arthritis, characterized by: The invention is prepared from the following raw materials in weight proportion: 10-20 parts of processed Chuanwu, 10-20 parts of processed Caowu, 10-20 parts of Zygophyllum dactylum, 10-20 parts of Prunus mume and 20-40 parts of Corydalis yanhusuo.

7. Use of the Chinese medicine composition according to claim 6 in preparing a medicine for treating joint swelling and pain caused by cold-dampness and blood stasis arthritis.

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