Preparation method of traditional Chinese medicine acupoint application for treating children allergic dermatitis

Abstract

The invention belongs to the crossing field of biological medicine and material science, and particularly relates to traditional Chinese medicine acupoint application for treating children allergic dermatitis and a preparation method of the traditional Chinese medicine acupoint application. The preparation method comprises the following steps: compounding prepared mesoporous hollow SiO2 microspheres with traditional Chinese medicine liquid for treating allergic dermatitis, then coating the traditional Chinese medicine patch with the compounded mesoporous hollow SiO2 microspheres, covering the traditional Chinese medicine patch with prepared ammonium bicarbonate compounded resin, airing at room temperature, and curing through ultraviolet rays. The mesoporous hollow SiO2 microspheres can be used as a traditional Chinese medicine carrier, so that the drug loading capacity is improved, and meanwhile, drug volatilization is reduced. In addition, medicine on the traditional Chinese medicine patch is covered with ammonium bicarbonate composite resin, medicine volatilization is further reduced, ammonium bicarbonate can be gasified by the temperature of the human body, holes are generated, the medicine can permeate out, and the traditional Chinese medicine patch is obtained through the process and is large in medicine carrying capacity and high in volatility resistance.

Description

Technical Field

[0001] The invention belongs to the interdisciplinary field of biomedicine and material science, and specifically relates to a preparation method of a Chinese medicine acupoint plaster for treating children's allergic dermatitis. Background Art

[0002] Allergic dermatitis in children is a common skin disease in children. Its symptoms are often diverse, usually manifested as a series of symptoms such as skin redness, obvious swelling, local fever, significant pain, and unbearable itching. The causes of allergic dermatitis in children are complex and varied. For example, bacterial invasion, fungal infection, contact with allergens, various external stimuli, etc., may all become factors that lead to allergic dermatitis in children.

[0003] In terms of treatment, the methods vary from disease to disease. Generally speaking, oral and topical drugs are covered. Clinically, oral and topical drugs are usually used in combination to deal with the various symptoms of acute attacks of skin inflammation and relieve the local or systemic inflammatory response of patients. Oral drugs can exert their therapeutic effects from the whole body system. However, whether it is antibiotics, hormones or immunosuppressants, they all have certain side effects, and long-term use may bring a series of adverse effects. Therefore, for those children with relatively mild allergic dermatitis, they are often more inclined to choose topical drugs for treatment. For a small amount of allergic dermatitis, topical drugs can be directly applied to the surface of the inflammation. For large areas of allergic dermatitis, if you don't want to apply drugs on a large area, applying drugs to the acupuncture points of the human body can often achieve faster drug effects. However, topical drugs are still inconvenient at the operational level. Among them, the key points that plague their application are that they are easy to contaminate clothes and bedding when applied on the skin surface and are not easy to exert their effects for a long time.

[0004] A Chinese patent (CN103623104A) discloses a Chinese medicine patch for treating inflammation of superficial skin parts and a preparation method thereof. The obtained Chinese medicine liquid is injected into the patch to make the Chinese medicine patch. This method can avoid the extravasation of the liquid medicine and staining of clothes. However, when the liquid medicine is directly injected into the patch, the drug evaporates quickly and is difficult to store for a long time, resulting in a sharp increase in the production, transportation, and storage costs of the corresponding Chinese medicine preparations, limiting its further market promotion and limiting its new possibility of providing more patients with improved skin topical medications. At the same time, the patent's operation of directly injecting the liquid medicine into the patch has a low drug loading, and there is room for technical innovation to further increase its drug loading and increase its efficacy. Summary of the invention

[0005] In order to overcome the drawbacks of the prior art, the present invention provides a method for preparing a Chinese medicine acupoint patch for treating allergic dermatitis in children. The Chinese medicine raw materials for clearing away heat and detoxifying, inhibiting bacteria and promoting blood circulation are used to achieve anti-inflammatory and antipruritic effects and promote skin tissue recovery. Mesoporous hollow SiO2 microspheres can be used as Chinese medicine carriers to increase drug loading and reduce drug volatilization. In addition, the drug on the Chinese medicine patch is covered with a resin compounded with ammonium bicarbonate to further reduce drug volatilization, and ammonium bicarbonate will vaporize at 30 to 60°C to generate holes, allowing the drug to penetrate out.

[0006] The technical solution adopted by the present invention to solve its technical problem is:

[0007] A preparation method of a Chinese medicine acupoint patch for treating children's allergic dermatitis, the preparation method comprising the following steps:

[0008] S1, mixing and grinding Strychnos nux vomica, Coptis chinensis, Sophora flavescens, Phellodendron amurense, Angelica dahurica, Rhubarb and Carthamus tinctorius, and then soaking them in anhydrous ethanol for 24 to 72 hours, and then centrifuging to obtain a Chinese medicine solution;

[0009] S2, 1 to 5 parts by weight of mesoporous hollow SiO2 microspheres are mixed with 50 to 200 parts by weight of the Chinese medicine solution in step S1, stirred for 3 to 6 hours, and then centrifuged to obtain mesoporous hollow SiO2 microspheres loaded with Chinese medicine, and then 5 to 30 parts by weight of the Chinese medicine solution in step S1 are added to the mesoporous hollow SiO2 microspheres, and ultrasonicated for 3 minutes to obtain a composite dispersion;

[0010] S3, the composite dispersion liquid described in step S2 is heated to 0.1-1 ml / cm 2 The dosage is injected onto the patch;

[0011] S4, then apply 0.04-0.1 ml / cm 2 The resin was injected with ammonium bicarbonate and then dried at room temperature and then passed through 400mJ / cm 2 UV-curing coating for 20 to 40 seconds;

[0012] It is further preferred as a preparation method of a Chinese medicine acupoint patch for treating children's allergic dermatitis.

[0013] Preferably, the added amounts of Strychnos nux vomica, Coptis chinensis, Sophora flavescens, Phellodendron chinense, Angelica dahurica, Rhubarb, Carthamus tinctorius and anhydrous ethanol described in step S1 are 5-7 mass parts, 5-7 mass parts, 5-7 mass parts, 2-4 mass parts, 2-3 mass parts, 5-7 mass parts and 5-7 mass parts, 200-500 mass parts respectively.

[0014] Preferably, the diameter size range of the mesoporous hollow SiO2 microspheres described in step S2 is 50 to 150 nm.

[0015] If the diameter of the mesoporous hollow SiO2 microspheres is too small, a large number of mesoporous hollow SiO2 microspheres cannot be centrifuged out during the centrifugation process and remain in the liquid. If the diameter of the mesoporous hollow SiO2 microspheres is too large, the mesoporous hollow SiO2 microspheres will precipitate in the traditional Chinese medicine solution and be difficult to disperse evenly.

[0016] Preferably, the preparation method of the ammonium bicarbonate composite resin described in step S4 is as follows: ammonium bicarbonate is dissolved in deionized water, and then anhydrous ethanol, pentaerythritol triacrylate and hydroxycyclohexyl phenyl ketone are added in sequence, and stirred in a light-proof condition.

[0017] Preferably, the addition amounts of ammonium bicarbonate, deionized water, anhydrous ethanol, pentaerythritol triacrylate and hydroxycyclohexyl phenyl ketone are 0.2-0.5 mass parts, 5-20 mass parts, 10-20 mass parts, 1-2 mass parts and 0.2-0.5 mass parts respectively.

[0018] If the amount of ammonium bicarbonate added is less than 0.2 parts by weight, the covering layer will not have sufficient pores after the ammonium bicarbonate is vaporized, making it difficult to release the traditional Chinese medicine solution.

[0019] According to the preparation method, a traditional Chinese medicine acupoint plaster for treating children's allergic dermatitis is prepared.

[0020] Nux vomica: It has the effects of clearing meridians, relieving pain, dispersing nodules and reducing swelling.

[0021] Coptis chinensis: can clear away heat and dampness, purge fire and detoxify.

[0022] Sophora flavescens: It has the effects of clearing away heat and dampness, killing insects and promoting diuresis.

[0023] Huangbai: can clear away heat and dampness, purge fire and eliminate steaming, detoxify and treat sores.

[0024] Angelica dahurica: It can relieve exterior symptoms and dispel cold, dispel wind and relieve pain, clear the nasal passages, dry up dampness and stop leukorrhea, reduce swelling and discharge pus.

[0025] Rhubarb: It has the effects of purging qi and removing accumulation, clearing away heat and purging fire, cooling blood and detoxifying, removing blood stasis and dredging menstruation.

[0026] Safflower: It has the effects of promoting blood circulation, relieving menstruation, dispersing blood stasis and relieving pain.

[0027] Compared with the prior art, the present invention has the following beneficial effects:

[0028] (1) Compared with directly injecting drugs into the Chinese medicine patch, which will cause the drugs to flow flat, thereby reducing the drug loading, the mesoporous hollow SiO2 microspheres prepared by the present invention can allow the Chinese medicine liquid to enter the cavity of the particles, and the mesoporous hollow SiO2 microspheres can fix the drug liquid inside the cavity, thereby increasing the drug loading capacity. In addition, the shell of the mesoporous hollow SiO2 microspheres can reduce the volatilization of the drug liquid.

[0029] (2) Compared with directly injecting the medicine liquid into the Chinese medicine patch, the present invention injects the Chinese medicine liquid mixed with mesoporous hollow SiO2 microspheres into the Chinese medicine patch, and then covers it with a layer of ammonium bicarbonate composite resin, which is cured by ultraviolet light, so that it can have a good sealing effect. The volatilization of the Chinese medicine liquid can be further reduced.

[0030] (3) The ammonium bicarbonate in the ammonium bicarbonate-compounded resin of the present invention hardly decomposes at room temperature, but decomposes to produce gas at a temperature above 30°C, thereby causing pores in the cured resin covering layer. The temperature of the human body just meets this condition, and the ammonium bicarbonate will be decomposed when the Chinese medicine patch is applied to the human body, thereby generating pores in the covering resin layer, allowing the drug solution to penetrate out. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 is a transmission electron microscope photograph of the mesoporous hollow SiO2 microspheres prepared in Example 1;

[0032] Figure 2 is a scanning electron microscope photograph of the mesoporous hollow SiO2 microspheres synthesized in Example 4;

[0033] Figure 3 is the N2 adsorption-desorption isotherm of the mesoporous hollow SiO2 microsphere powder synthesized in Example 4;

[0034] Figure 4 is a transmission electron microscope photograph of the Chinese medicine mixed with mesoporous hollow SiO2 microspheres in Example 4;

[0035] Figure 5 (a) and 5(b) are scanning electron micrographs of the ammonium bicarbonate composite resin prepared in Example 2 and after heating at 36°C for 30 min, respectively;

[0036] Figure 6 is a scanning electron microscope photograph of the ammonium bicarbonate composite resin prepared in Comparative Example 2 after being heated at 36° C. for 30 minutes;

[0037] Figure 7 is the drug volatilization curve of the Chinese medicine patch prepared in Comparative Example 1 and Examples 1-5;

[0038] Figure 8 It is a bar graph of the drug loading of the Chinese medicine patches prepared in Comparative Example 1 and Examples 1-5. DETAILED DESCRIPTION

[0039] The present invention will be further described below in conjunction with embodiments and comparative examples.

[0040] Example 1

[0041] This embodiment provides a Chinese medicine acupoint application for treating children's allergic dermatitis and a preparation method thereof, which specifically comprises the following steps:

[0042] S1, mix and grind 5 parts by mass of Strychnos nux vomica, 5 parts by mass of Coptis chinensis, 5 parts by mass of Sophora flavescens, 2 parts by mass of Phellodendron chinense, 2 parts by mass of Angelica dahurica, 5 parts by mass of Rhubarb and 5 parts by mass of Carthamus tinctorius, then soak them in 200 parts by mass of anhydrous ethanol for 24 hours, and then obtain a Chinese medicine liquid by centrifugation;

[0043] S2, mixing 1 mass part of the mesoporous hollow SiO2 microspheres with 50 mass parts of the Chinese medicine solution in step S1, stirring for 3 hours, and then centrifuging to obtain the mesoporous hollow SiO2 microspheres loaded with Chinese medicine, and then adding 5 mass parts of the Chinese medicine solution in step S1 to the mesoporous hollow SiO2 microspheres, ultrasonicating for 3 minutes, and obtaining a composite dispersion;

[0044] S3, the mixed solution described in step S2 was added at 0.1 ml / cm 2 The dosage is injected onto the patch;

[0045] S4, the liquid in step S3 is heated at 0.04 ml / cm 2 The resin was injected with ammonium bicarbonate and then dried at room temperature and then passed through 400mJ / cm 2 UV-cured coating for 20s;

[0046] The preparation method of the ammonium bicarbonate composite resin described in step S4 specifically comprises the following steps: dissolving 0.2 parts by mass of ammonium bicarbonate in 5 parts by mass of deionized water, then adding 10 parts by mass of anhydrous ethanol, 1 part by mass of pentaerythritol triacrylate and 0.2 parts by mass of hydroxycyclohexyl phenyl ketone in sequence, and stirring in a light-proof condition.

[0047] According to the above method, a Chinese medicine acupoint plaster for treating children's allergic dermatitis is obtained.

[0048] Example 2

[0049] This embodiment provides a Chinese medicine acupoint application for treating children's allergic dermatitis and a preparation method thereof, which specifically comprises the following steps:

[0050] S1, mix and grind 7 parts by mass of Strychnos nux vomica, 7 parts by mass of Coptis chinensis, 7 parts by mass of Sophora flavescens, 4 parts by mass of Phellodendron chinense, 3 parts by mass of Angelica dahurica, 7 parts by mass of Rhubarb and 7 parts by mass of Carthamus tinctorius, then soak them in 500 parts by mass of anhydrous ethanol for 72 hours, and then obtain a Chinese medicine liquid by centrifugation;

[0051] S2, 5 parts by mass of the mesoporous hollow SiO2 microspheres were mixed with 200 parts by mass of the Chinese medicine solution in step S1, stirred for 6 hours, and then centrifuged to obtain the mesoporous hollow SiO2 microspheres loaded with Chinese medicine, and then 30 parts by mass of the Chinese medicine solution in step S1 were added to the mesoporous hollow SiO2 microspheres, and ultrasonicated for 3 minutes to obtain a composite dispersion.

[0052] S3, take the mixed solution described in step S2 at 1ml / cm 2 The dosage is injected onto the patch;

[0053] S4, the liquid in step S3 is heated at 0.1 ml / cm 2 The resin was injected with ammonium bicarbonate and then dried at room temperature and then passed through 400mJ / cm 2 UV-cured coating for 20s;

[0054] Among them, the preparation method of the ammonium bicarbonate composite resin described in step S4 specifically includes the following steps: dissolving 0.5 parts by mass of ammonium bicarbonate in 20 parts by mass of deionized water, and then adding 200 parts by mass of anhydrous ethanol, 2 parts by mass of pentaerythritol triacrylate and 0.5 parts by mass of hydroxycyclohexyl phenyl ketone in sequence, and stirring under light-proof conditions.

[0055] According to the above method, a Chinese medicine acupoint plaster for treating children's allergic dermatitis is obtained.

[0056] Example 3

[0057] This embodiment provides a Chinese medicine acupoint application for treating children's allergic dermatitis and a preparation method thereof, which specifically comprises the following steps:

[0058] S1, mix and grind 6 parts by mass of Strychnos nux vomica, 6 parts by mass of Coptis chinensis, 6 parts by mass of Sophora flavescens, 3 parts by mass of Phellodendron chinense, 3 parts by mass of Angelica dahurica, 6 parts by mass of Rhubarb and 6 parts by mass of Carthamus tinctorius, then soak them in 300 parts by mass of anhydrous ethanol for 36 hours, and then obtain a Chinese medicine liquid by centrifugation;

[0059] S2, 3 parts by mass of the mesoporous hollow SiO2 microspheres were mixed with 100 parts by mass of the Chinese medicine solution in step S1, stirred for 4 hours, and then centrifuged to obtain the mesoporous hollow SiO2 microspheres loaded with Chinese medicine, and then 15 parts by mass of the Chinese medicine solution in step S1 were added to the mesoporous hollow SiO2 microspheres, and ultrasonicated for 3 minutes to obtain a composite dispersion;

[0060] S3, the mixed solution described in step S2 was added at 0.4 ml / cm 2 The dosage is injected onto the patch;

[0061] S4, the liquid in step S3 is heated at 0.08 ml / cm 2 The resin was injected with ammonium bicarbonate and then dried at room temperature and then passed through 400mJ / cm 2 UV-cured coating for 20s;

[0062] The preparation method of the ammonium bicarbonate composite resin described in step S4 specifically comprises the following steps: dissolving 0.3 parts by mass of ammonium bicarbonate in 10 parts by mass of deionized water, then adding 15 parts by mass of anhydrous ethanol, 1.5 parts by mass of pentaerythritol triacrylate and 0.3 parts by mass of hydroxycyclohexyl phenyl ketone in sequence, and stirring in a light-proof condition.

[0063] According to the above method, a Chinese medicine acupoint plaster for treating children's allergic dermatitis is obtained.

[0064] Example 4

[0065] This embodiment provides a Chinese medicine acupoint application for treating children's allergic dermatitis and a preparation method thereof, which specifically comprises the following steps:

[0066] S1, mix and grind 6 parts by mass of Strychnos nux vomica, 6 parts by mass of Coptis chinensis, 6 parts by mass of Sophora flavescens, 3 parts by mass of Phellodendron chinense, 3 parts by mass of Angelica dahurica, 6 parts by mass of Rhubarb and 6 parts by mass of Carthamus tinctorius, then soak them in 300 parts by mass of anhydrous ethanol for 36 hours, and then obtain a Chinese medicine liquid by centrifugation;

[0067] S2, mixing 1 mass part of the mesoporous hollow SiO2 microspheres with 50 mass parts of the Chinese medicine solution in step S1, stirring for 3 hours, and then centrifuging to obtain the mesoporous hollow SiO2 microspheres loaded with Chinese medicine, and then adding 5 mass parts of the Chinese medicine solution in step S1 to the mesoporous hollow SiO2 microspheres, ultrasonicating for 3 minutes, and obtaining a composite dispersion;

[0068] S3, the mixed solution described in step S2 was added at 0.5 ml / cm 2 The dosage is injected onto the patch;

[0069] S4, the liquid in step S3 is heated at 0.06 ml / cm2 The resin was injected with ammonium bicarbonate and then dried at room temperature and then passed through 400mJ / cm 2 UV-cured coating for 20 s.

[0070] The preparation method of the ammonium bicarbonate composite resin described in step S4 specifically comprises the following steps: dissolving 0.2 parts by mass of ammonium bicarbonate in 5 parts by mass of deionized water, then adding 12 parts by mass of anhydrous ethanol, 1.5 parts by mass of pentaerythritol triacrylate and 0.3 parts by mass of hydroxycyclohexyl phenyl ketone in sequence, and stirring in a light-proof condition.

[0071] According to the above method, a Chinese medicine acupoint plaster for treating children's allergic dermatitis is obtained.

[0072] Example 5

[0073] This embodiment provides a Chinese medicine acupoint application for treating children's allergic dermatitis and a preparation method thereof, which specifically comprises the following steps:

[0074] S1, mix and grind 5 parts by mass of Strychnos nux vomica, 5 parts by mass of Coptis chinensis, 5 parts by mass of Sophora flavescens, 2 parts by mass of Phellodendron chinense, 2 parts by mass of Angelica dahurica, 5 parts by mass of Rhubarb and 5 parts by mass of Carthamus tinctorius, then soak them in 200 parts by mass of anhydrous ethanol for 24 hours, and then obtain a Chinese medicine liquid by centrifugation;

[0075] S2, mixing 1 mass part of the mesoporous hollow SiO2 microspheres with 50 mass parts of the Chinese medicine solution in step S1, stirring for 3 hours, and then centrifuging to obtain the mesoporous hollow SiO2 microspheres loaded with Chinese medicine, and then adding 5 mass parts of the Chinese medicine solution in step S1 to the mesoporous hollow SiO2 microspheres, ultrasonicating for 3 minutes, and obtaining a composite dispersion;

[0076] S3, the mixed solution described in step S2 was added at 0.1 ml / cm 2 The dosage is injected onto the patch;

[0077] S4, the liquid in step S3 is heated at 0.04 ml / cm 2 The resin was injected with ammonium bicarbonate and then dried at room temperature and then passed through 400mJ / cm 2 UV-cured coating for 20s;

[0078] Among them, the preparation method of the ammonium bicarbonate composite resin described in step S4 specifically includes the following steps: dissolving 0.2 parts by mass of ammonium bicarbonate in 5 parts by mass of deionized water, and then adding 10 parts by mass of anhydrous ethanol, 1 part by mass of pentaerythritol triacrylate and 0.2 parts by mass of hydroxycyclohexyl phenyl ketone in sequence, and stirring under light-proof conditions.

[0079] According to the above method, a Chinese medicine acupoint plaster for treating children's allergic dermatitis is obtained.

[0080] Comparative Example 1

[0081] This comparative example provides a preparation method for directly injecting a Chinese medicine liquid into a Chinese medicine patch, which specifically comprises the following steps:

[0082] S1, mix and grind 5 parts by mass of Strychnos nux vomica, 5 parts by mass of Coptis chinensis, 5 parts by mass of Sophora flavescens, 2 parts by mass of Phellodendron chinense, 2 parts by mass of Angelica dahurica, 5 parts by mass of Rhubarb and 5 parts by mass of Carthamus tinctorius, then soak them in 200 parts by mass of anhydrous ethanol for 24 hours, and then obtain a Chinese medicine liquid by centrifugation;

[0083] S2, the Chinese medicine solution described in step S1 was added at 0.1 ml / cm 2 The dosage is injected onto the patch;

[0084] According to the above method, a Chinese medicine acupoint plaster for treating children's allergic dermatitis is obtained.

[0085] Comparative Example 2

[0086] This comparative example provides a Chinese medicine acupoint application for treating allergic dermatitis in children and a preparation method thereof. The amount of ammonium bicarbonate added in this comparative example is 1 part by mass, and the other parts are the same as Example 2.

[0087] Comparative Example 3

[0088] This comparative example provides a Chinese medicine acupoint application for treating allergic dermatitis in children and a preparation method thereof. The size range of the mesoporous hollow SiO2 microspheres in this comparative example is 200-300 nm, and the other parts are the same as those in Example 1.

[0089] In Comparative Example 3, the mesoporous hollow SiO2 microspheres precipitated in the traditional Chinese medicine solution and were difficult to disperse.

[0090] Figure 1 This is a transmission electron microscope photo of the mesoporous hollow SiO2 microspheres prepared in Example 1. It can be seen that the diameter size of the synthesized mesoporous hollow SiO2 microspheres is distributed in the range of 50 to 150 nm, and there is a large inner cavity structure that can carry the Chinese medicine liquid.

[0091] Figure 2 This is a scanning electron microscope photo of the mesoporous hollow SiO2 microspheres synthesized in Example 4. This shows that the drug solution can enter and exit the hollow SiO2 microspheres through the mesopores, and can play a good role in absorption and release.

[0092] Figure 3 This is the N2 adsorption-desorption isotherm of the mesoporous hollow SiO2 microsphere powder synthesized in Example 4. It can be seen that the specific surface area is relatively high, which is caused by the mesoporous and hollow structure of the SiO2 microsphere.

[0093] Figure 4 This is a transmission electron microscope photo of the Chinese medicine mixed with the mesoporous hollow SiO2 microspheres in Example 4. The photo shows that after the mesoporous hollow SiO2 microspheres are mixed with the Chinese medicine solution, the medicine enters the inner cavity of the microspheres.

[0094] Figure 5 (a) and 5(b) are scanning electron micrographs of the ammonium bicarbonate composite resin prepared in Example 2 and after heating at 36°C for 30 min, respectively. Figure 5 (a) It shows that the surface of the ammonium bicarbonate composite resin is very dense and has good sealing properties. After heating at 36℃, Figure 5 (b) Many pores will appear on the surface, allowing the Chinese medicine solution to penetrate.

[0095] Figure 6 This is a scanning electron microscope photograph of the ammonium bicarbonate composite resin prepared in Example 2 after heating at 36°C for 30 minutes. It can be seen that there are fewer pores on the surface of the coating, which means that when the amount of ammonium bicarbonate added is 0.1, it is not enough to form sufficient pores, resulting in difficulty in drug release.

[0096] Figure 7 The drug volatilization curves of the Chinese medicine patches prepared in Comparative Example 1 and Examples 1 to 5 are shown in FIG. 1. It can be clearly seen that the Chinese medicine liquid in the comparative example volatilizes quickly, while the medicine in the examples volatilizes slowly.

[0097] Figure 8 It is a bar graph of the drug loading of the Chinese medicine patch prepared in comparative example 1 and examples 1 to 5. It can be seen that the drug loading of examples 1 to 5 is higher than that of the comparative example, which shows that the Chinese medicine patch prepared by the present invention has increased its drug loading.

[0098] From the experimental results of the above comparative examples 1 to 2 and embodiments 1 to 5, it can be seen that the present invention has prepared a Chinese medicine acupoint patch for treating children's allergic dermatitis.

[0099] Those skilled in the art should understand that the above are only some specific embodiments of the present invention, rather than all embodiments. It should be noted that for those of ordinary skill in the art, many modifications and improvements can be made, and all modifications or improvements that do not exceed the scope of protection of the present invention should be regarded as the scope of protection of the present invention.

Claims

1. A preparation method of a Chinese medicine acupoint patch for treating allergic dermatitis in children, characterized in that: The following steps are involved: S1, mixing and grinding Strychnos nux vomica, Coptis chinensis, Sophora flavescens, Phellodendron amurense, Angelica dahurica, Rhubarb and Carthamus tinctorius, and then soaking them in anhydrous ethanol for 24 to 72 hours, and then centrifuging to obtain a Chinese medicine solution; S2, 1 to 5 parts by weight of mesoporous hollow SiO2 microspheres are mixed with 50 to 200 parts by weight of the Chinese medicine solution in step S1, stirred for 3 to 6 hours, and then centrifuged to obtain mesoporous hollow SiO2 microspheres loaded with Chinese medicine, and then 5 to 30 parts by weight of the Chinese medicine solution in step S1 are added to the mesoporous hollow SiO2 microspheres, and ultrasonicated for 3 minutes to obtain a composite dispersion; S3, the composite dispersion liquid described in step S2 is heated to 0.1-1 ml / cm 2 The dosage is injected onto the patch; S4, then apply 0.04-0.1 ml / cm 2 The resin was injected with ammonium bicarbonate and then dried at room temperature and then passed through 400mJ / cm 2 The UV-curing coating lasts for 20 to 40 seconds.

2. The method for preparing the Chinese medicine acupoint patch for treating allergic dermatitis in children according to claim 1, characterized in that: The added amounts of Strychnos nux vomica, Coptis chinensis, Sophora flavescens, Phellodendron amurense, Angelica dahurica, Rhubarb, Carthamus tinctorius and anhydrous ethanol described in step S1 are 5-7 parts by mass, 5-7 parts by mass, 5-7 parts by mass, 2-4 parts by mass, 2-3 parts by mass, 5-7 parts by mass and 5-7 parts by mass, and 200-500 parts by mass, respectively.

3. The preparation method of a Chinese medicine acupoint patch for treating allergic dermatitis in children according to claim 1, characterized in that: The diameter size range of the mesoporous hollow SiO2 microspheres described in step S2 is 50 to 150 nm.

4. The method for preparing a Chinese medicine acupoint patch for treating allergic dermatitis in children according to claim 1, characterized in that: The preparation method of the ammonium bicarbonate composite resin described in step S4 is as follows: ammonium bicarbonate is dissolved in deionized water, and then anhydrous ethanol, pentaerythritol triacrylate and hydroxycyclohexyl phenyl ketone are added in sequence, and stirred in a light-proof condition.

5. The method for preparing a Chinese medicine acupoint patch for treating allergic dermatitis in children according to claim 4, characterized in that The addition amounts of the ammonium bicarbonate, deionized water, anhydrous ethanol, pentaerythritol triacrylate and hydroxycyclohexyl phenyl ketone are 0.2-0.5 mass parts, 5-20 mass parts, 10-20 mass parts, 1-2 mass parts and 0.2-0.5 mass parts respectively.

6. A Chinese medicine acupoint plaster for treating children's allergic dermatitis prepared by the preparation method according to any one of claims 1 to 5.

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