Traditional Chinese medicine formula for treating heart-spleen deficiency type chronic heart failure and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine formula for treating heart-spleen deficiency type chronic heart failure and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compound preparations. Comprising 9 g of ginseng slices, 15 g of radix astragali, 12 g of poria cocos, 12 g of raw atractylodes macrocephala koidz, 12 g of radix paeoniae rubra, 12 g of rhodiola rosea, 12 g of acanthopanax senticosus and 12 g of radix polygonati officinalis, 31.5 g of ginseng slices, 52.5 g of radix astragali, 42 g of poria cocos, 42 g of raw atractylodes macrocephala koidz, 42 g of radix paeoniae rubra, 42 g of rhodiola rosea, 42 g of acanthopanax senticosus and 42 g of radix polygonati officinalis are taken out and decocted, liquid medicine is obtained and ground into powder, and a plurality of pills are prepared; according to the traditional Chinese medicine formula for treating heart-spleen deficiency type chronic heart failure and the preparation method thereof, the symptoms of chronic heart failure can be improved, the quality is relatively controllable, and meanwhile, the traditional Chinese medicine formula can benefit qi, invigorate the spleen, activate blood and enrich blood.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine compound preparations, in particular to a Chinese medicine formula for treating chronic heart failure of deficiency of both heart and spleen and a preparation method thereof. Background Art

[0002] Cardiovascular disease is one of the leading causes of death worldwide. The prevalence of heart failure is high and imposes a huge economic burden on society. Although Western medicines for the treatment of chronic heart failure have clear pharmacological mechanisms and efficacy, they have many contraindications and side effects, and some patients are afraid of taking Western medicines for a long time. Traditional Chinese medicine has unique advantages in comprehensively improving patients' clinical symptoms, enhancing the efficacy of Western medicines, and reducing adverse reactions of Western medicines because of its multi-pathway, multi-target, and individualized intervention effects. Summary of the invention

[0003] The object of the present invention is to provide a Chinese medicine formula for treating chronic heart failure of deficiency of both heart and spleen and a preparation method thereof, so as to solve the problems raised in the above background technology.

[0004] In view of the above problems, the technical solution proposed by the present invention is:

[0005] A traditional Chinese medicine formula for treating chronic heart failure of deficiency of both heart and spleen type is prepared from the following ingredients: 9g of ginseng slices, 15g of astragalus, 12g of poria, 12g of raw atractylodes, 12g of red peony root, 12g of rhodiola rosea, 12g of acanthopanax senticosus, and 12g of polygonatum odoratum, wherein the ginseng slices, astragalus, poria, raw atractylodes, red peony root, rhodiola rosea, acanthopanax senticosus, and polygonatum odoratum are all in seven parts.

[0006] As a preferred technical solution of the present invention, the method of using the formula is: twice a day, and one course of treatment is every twenty-eight days.

[0007] In another aspect, the present invention provides a method for preparing a Chinese medicine formula for treating chronic heart failure of the deficiency of both heart and spleen type, comprising the following steps:

[0008] Step 1, take seven portions of medicinal materials, each portion of which contains 9g of ginseng slices, 15g of astragalus, 12g of Poria, 12g of raw Atractylodes macrocephala, 12g of red peony root, 12g of Rhodiola rosea, 12g of Acanthopanax senticosus, and 12g of Polygonatum odoratum;

[0009] Step 2: Select a container bottle of suitable size, clean and disinfect it inside and outside, then pour 63g of dried ginseng slices, 105g of astragalus, 84g of Poria, 84g of raw Atractylodes macrocephala, 84g of red peony root, 84g of Rhodiola rosea, 84g of Acanthopanax senticosus, and 84g of Polygonatum odoratum into the container bottle, pour clean water to wash the above raw materials, and drain;

[0010] Step 3: Take out 31.5g of ginseng slices, 52.5g of astragalus, 42g of Poria, 42g of raw Atractylodes, 42g of red peony root, 42g of Rhodiola rosea, 42g of Acanthopanax senticosus, and 42g of Polygonatum odoratum and boil them to obtain liquid medicine; take out 31.5g of ginseng slices, 52.5g of astragalus, 42g of Poria, 42g of raw Atractylodes, 42g of red peony root, 42g of Rhodiola rosea, 42g of Acanthopanax senticosus, and 42g of Polygonatum odoratum and grind them into powder to obtain medicinal powder;

[0011] Step 4: Mix the liquid medicine and powder together and make several pellets with a diameter of 3-5 mm.

[0012] As a preferred technical solution of the present invention, the decoction in step three is carried out in a clay pot, the powdering in step three is carried out in a Chinese medicine grinder, the mixing in step four is carried out in a mixer, and the pellets in step four are made by a pill rolling machine.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] 1. The Chinese medicine formula for treating chronic heart failure of the deficiency of both heart and spleen and its preparation method can improve the clinical symptoms of patients with chronic heart failure of the deficiency of both heart and spleen, such as palpitations, shortness of breath, fatigue, chest tightness, etc., increase activity tolerance, and improve the quality of life of patients with chronic heart failure;

[0015] 2. The Chinese medicine formula for treating chronic heart failure of the heart and spleen deficiency type and its preparation method can improve the NYHA cardiac function index of patients with chronic heart failure of the heart and spleen deficiency type, improve LVEF, LVIDd and other echocardiographic indexes, and can be taken for a long time as a prognosis-improving drug to improve the long-term clinical prognosis of patients;

[0016] 3. The traditional Chinese medicine formula for treating chronic heart failure of the deficiency of both heart and spleen and its preparation method can improve the myocardial energy metabolism of patients with chronic heart failure of the deficiency of both heart and spleen. DETAILED DESCRIPTION

[0017] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0018] Embodiment 1

[0019] Dong, female, 84 years old, was re-examined for heart failure, coronary heart disease, and essential hypertension. After taking spironolactone and furosemide, the creatinine and uric acid increased and the medication was stopped. After changing to Noxinto, the condition improved, and the blood pressure was low. After taking aspirin, gastrointestinal bleeding occurred. Now Noxinto is taken to lower blood pressure and improve ventricular remodeling, metoprolol sustained-release tablets to lower blood pressure, atorvastatin and ezetimibe to regulate lipids and stabilize spots. Now the heartbeat is fast, chest tightness and shortness of breath after activities, bitter mouth, bloating, poor appetite, poor sleep at night, and dry stool. The pulse is deep and thin, the tongue is red and greasy, and there are teeth marks on the edges. After taking the Yixin Jianpi prescription on the basis of Western medicine for 6 courses, the patient now has no obvious chest tightness and shortness of breath, the symptoms of stomach discomfort have basically disappeared, the appetite has improved, the sleep at night has become peaceful, and the LVEF of the echocardiogram has increased from 43% to 50%.

[0020] Zhang, male, 84 years old, re-examination for coronary heart disease and heart failure. He was discharged from our department on December 19, 2023, and was diagnosed with "heart failure heart function level; coronary heart disease; hypertension level 2; type 2 diabetes; carotid artery plaque; ventricular premature beats, etc.", and took standardized oral coronary heart disease secondary prevention drugs, diuretics, hypoglycemic drugs, etc. He occasionally had chest tightness and chest pain, dizziness in the morning, fatigue from time to time, poor appetite, and good sleep at night. The pulse was stringy, the tongue was light red with a thin light yellow coating, and the sublingual collaterals were blue and purple. After taking Yixin Jianpi Fang pills orally for 4 courses on the basis of Western medicine, there is no obvious chest tightness and chest pain, the dizziness in the morning disappeared, the appetite and sleep were good, and the heart function changed from level IV to level II.

[0021] Fang, female, 71 years old, re-examined for coronary heart disease and heart failure. Currently taking antiplatelet aggregation, lipid-regulating and plaque-stabilizing, antihypertensive and hypoglycemic drugs. Occasionally, she has chest tightness and chest pain, which lasts for 2 minutes each time and can be relieved by herself. She has phlegm in the throat, acid reflux, fatigue, discomfort in the middle abdomen, occasional hypoglycemia, dizziness and heaviness in the head. The pulse is thin and weak, and the tongue is light red with thin white fur. After taking Yixin Jianpi Fang pills orally for 6 courses, the patient had no obvious dizziness, fatigue improved, chest pain and chest tightness did not occur significantly, blood sugar was stable, and the discomfort in the middle abdomen improved, and the condition was stable.

[0022] Jin, female, 70 years old, heart failure, coronary artery stent implantation status. Coronary artery stent implantation was performed in August 2021. On July 15, 2022, coronary angiography was repeated in the Dingqiao campus of our hospital, and a stent was implanted in the proximal middle segment of the anterior descending branch. Now it is treated with drugs such as antihypertensive and lipid-lowering, antiplatelet aggregation, lipid-regulating and plaque-stabilizing, improving myocardial metabolism, hypoglycemic, and diuretic. Recently, there have been repeated sweating, fatigue, loose stools, poor appetite, restless sleep, bloating and pain in the back of the head, and soreness in the right shoulder. The pulse is stringy and thin, the tongue is light purple and the coating is thin and white, there are tooth marks on the edges, and the sublingual collaterals are blue and purple. After taking Yixin Jianpi Fang pills orally for 5 courses, the patient's whole body sweating decreased, the stool became normal, the fatigue improved, the appetite improved, the sleep became peaceful, the condition was stable, and the heart function changed from grade II to grade III to grade II.

[0023] Embodiment 2

[0024] Experimental methods:

[0025] A total of 60 patients with heart failure (heart and spleen deficiency syndrome) were enrolled from the outpatient and inpatient departments of Hangzhou Traditional Chinese Medicine Hospital and randomly divided into a control group and a treatment group of 30 cases each. The control group was given standard Western medicine treatment, and the treatment group was treated with Yixin Jianpi Pills on the basis of standard Western medicine treatment (28 days as a course of treatment, 12g / time, 2 times / day). The treatment course for both groups was 6 weeks. The clinical symptoms, signs, cardiac function, and TCM syndrome scores of the patients were evaluated within 24 hours after enrollment and after 6 weeks of treatment. The levels of HGF and VEGF before and after treatment were detected and recorded, and echocardiography was performed before and after treatment.

[0026] Experimental data:

[0027] 1. Effect of Yixin Jianpi Recipe on TCM Symptom Score

[0028] After treatment, the difference in TCM symptom scores between the two groups showed statistically significant difference, indicating that combined treatment with Yixin Jianpi prescription can better improve the clinical symptoms of patients.

[0029] Table 1 Comparison of TCM symptom scores before and after treatment

[0030]

[0031] Note: Compared with the same group before treatment, ** indicates P < 0.01; compared with the control group after treatment, ## indicates P < 0.05.

[0032] 2. Comparison of the effects of Yixin Jianpi prescription on cardiac function in patients with heart failure

[0033] 1. Comparison of cardiac function classification at admission

[0034] The cardiac function of the treatment group and the control group before treatment was compared by X2 test, X2=0.069, P=0.793 (>0.05). It can be seen that there was no statistically significant difference in NYHA cardiac function classification between the two groups before treatment, and the two groups were comparable.

[0035] Table 2-1 Comparison of cardiac function classification at admission

[0036]

[0037] (II) Comparison of NYHA cardiac function between the two groups after treatment

[0038] The total effective rate of the two groups of patients after treatment was 80%, and the effective rates of the treatment group and the control group were 90% and 70%, respectively. Because the data were ordered categorical data, the rank sum test was used as the statistical method, Z=3.040, P=0.002 (<0.05), indicating that the difference in cardiac function improvement between the treatment group and the control group after treatment was statistically significant, and the improvement in cardiac function in the treatment group was better than that in the control group.

[0039] Table 2-2 Comparison of NYHA cardiac function efficacy after treatment

[0040]

[0041] Note: Compared with the control group after treatment, ## indicates P<0.01.

[0042] 3. Safety study of Yixin Jianpi prescription

[0043] The comparison of alanine aminotransferase, aspartate aminotransferase, creatinine and blood potassium values ​​before and after treatment were all P<0.05, indicating that the Yixin Jianpi prescription did not cause obvious liver and kidney function damage, electrolyte disorder and other adverse damages.

[0044] Table 3 Comparison of the values ​​of alanine aminotransferase (U / L), aspartate aminotransferase (U / L), creatinine (umol / L), and blood potassium (mmol / L) in the treatment groups before and after treatment

[0045]

[0046] 4. Comparison of serum HGF and VEGF before and after treatment (I) Comparison of serum VEGF before and after treatment

[0047] The VEGF levels in the treatment group before and after treatment were analyzed using a two-sample paired t-test, t=8.402, P=0.000 (<0.05), and the difference was statistically significant; the VEGF levels in the control group before and after treatment were analyzed using a two-sample paired t-test, t=5.394, P=0.000 (<0.05), and the difference was statistically significant; the serum VEGF levels of the two groups after treatment were analyzed using a t-test, P value (significance)=0.204, and the variance was homogeneous, so t=1.364, P=0.178 (<0.05), and there was no statistical difference in serum VEGF levels between the two groups of patients after treatment (P>0.05), indicating that there was no significant statistical difference in the decrease in serum VEGF levels between the treatment group and the control group.

[0048] Table 4-1 Comparison of serum VEGF levels before and after treatment (pg / ml)

[0049]

[0050] Note: Compared with the same group before treatment, ** indicates P < 0.01.

[0051] (II) Comparison of serum HGF before and after treatment

[0052] The HGF levels in the treatment group before and after treatment were analyzed by two-sample paired t-test, t=6.119, P=0.000(<0.05), and the difference was statistically significant; the HGF levels in the control group before and after treatment were analyzed by two-sample paired t-test, t=4.061, P=0.000(<0.05), and the difference was statistically significant; the serum HGF levels of the two groups after treatment were analyzed by t-test, P value (significance)=0.188, and the variance was homogeneous, so t=2.438, P=0.018(<0.05), and the difference in serum HGF levels between the two groups of patients after treatment was statistically significant (P<0.05), indicating that the HGF level in the treatment group decreased more significantly.

[0053] Table 4-2 Comparison of serum HGF levels before and after treatment (pg / ml)

[0054]

[0055] Experimental conclusion:

[0056] Yixin Jianpi prescription can effectively improve the clinical symptoms of patients with chronic heart failure with deficiency of both heart and spleen; Yixin Jianpi prescription can reduce the level of HGF in the serum of patients with heart failure; the effect of Yixin Jianpi prescription in reducing the level of VEGF is not yet clear; Yixin Jianpi prescription has good safety in the treatment of chronic heart failure.

Claims

1. A Chinese medicine formula for treating chronic heart failure of heart and spleen deficiency type, characterized in that: The invention is prepared from the following ingredients: 9g of ginseng slices, 15g of astragalus, 12g of poria, 12g of raw atractylodes, 12g of red peony root, 12g of rhodiola rosea, 12g of acanthopanax senticosus, and 12g of polygonatum odoratum, and the ginseng slices, astragalus, poria, raw atractylodes, red peony root, rhodiola rosea, acanthopanax senticosus, and polygonatum odoratum are all in seven portions.

2. A Chinese medicine formula for treating chronic heart failure of heart and spleen deficiency type according to claim 1, characterized in that: The method of using the formula is: twice a day, and one course of treatment is every 28 days.

3. A method for preparing a Chinese medicine formula for treating chronic heart failure of the heart and spleen deficiency type, as applied to a Chinese medicine formula for treating chronic heart failure of the heart and spleen deficiency type as described in claims 1-2, characterized in that: The following steps are involved: Step 1, take seven portions of medicinal materials, each portion of which contains 9g of ginseng slices, 15g of astragalus, 12g of Poria, 12g of raw Atractylodes macrocephala, 12g of red peony root, 12g of Rhodiola rosea, 12g of Acanthopanax senticosus, and 12g of Polygonatum odoratum; Step 2: Select a container bottle of suitable size, clean and disinfect it inside and outside, then pour 63g of dried ginseng slices, 105g of astragalus, 84g of Poria, 84g of raw Atractylodes macrocephala, 84g of red peony root, 84g of Rhodiola rosea, 84g of Acanthopanax senticosus, and 84g of Polygonatum odoratum into the container bottle, pour clean water to wash the above raw materials, and drain; Step 3: Take out 31.5g of ginseng slices, 52.5g of astragalus, 42g of Poria, 42g of raw Atractylodes, 42g of red peony root, 42g of Rhodiola rosea, 42g of Acanthopanax senticosus, and 42g of Polygonatum odoratum and boil them to obtain liquid medicine; take out 31.5g of ginseng slices, 52.5g of astragalus, 42g of Poria, 42g of raw Atractylodes, 42g of red peony root, 42g of Rhodiola rosea, 42g of Acanthopanax senticosus, and 42g of Polygonatum odoratum and grind them into powder to obtain medicinal powder; Step 4: Mix the liquid medicine and powder together and make several pellets with a diameter of 3-5 mm.

4. The method for preparing a traditional Chinese medicine formula for treating chronic heart failure of deficiency of both heart and spleen according to claim 3, characterized in that: The decoction in step three is carried out in a clay pot, the powdering in step three is carried out in a Chinese medicine grinder, the mixing in step four is carried out in a mixer, and the pellets in step four are made by a pill rolling machine.

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