Guide wire connecting guide tube

Abstract

The guide wire connecting guide tube comprises a control handle, a main tube and a flaring control assembly, the main tube comprises a main body section and a flaring section, the near end of the main body section is connected to the control handle, the far end of the main body section is connected to the near end of the flaring section, a wire storage hole is formed in the tube wall of the main tube, the flaring section comprises an elastic outer layer, and the wire storage hole extends to the elastic outer layer; the flaring control assembly comprises a driven wire, a driving wire, a traction wire and a rotating mechanism, the far end of the driven wire penetrates through the elastic outer layer along the wire storage hole, the driven wire and the wire storage hole are fixed to the inner wall, located on the elastic outer layer, of the wire storage hole, the far end of the driving wire is connected with the far end of the driven wire, and the rotating mechanism is arranged on the control handle and used for pulling the driving wire through the traction wire. The guide wire is connected with the guide tube, the driving wire is dragged by the knob mechanism through the traction wire, so that the driving traction wire drives the driven wire to apply tension towards the near end to the flaring section, the flaring angle of the flaring section is adjusted, the reverse threading success rate is increased, and the reverse threading time is shortened.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to a guidewire-connected catheter. Background Art

[0002] In the process of using minimally invasive interventional methods to treat sclerosis obliterans of the lower limbs, it is necessary to first use a guidewire to pass through the lesion, and then use the guidewire to guide the sheath to the target lesion, so that the sheath provides a channel and protection for other instruments, and finally insert other instruments for treatment.

[0003] However, the blood vessels of the lower extremities often have severe calcification and plaques, and the guidewire cannot smoothly pass through the lesions. Doctors usually choose the reverse puncture method, which is to add a puncture point in the infrapopliteal artery, use the guidewire to pass through the lesion upward, and dock with the descending guidewire or sheath to increase the technical success rate of passing the target lesion.

[0004] However, the guidewire docking in the reverse threading method is a long process, which especially tests the doctor's skills and patience. Figure 1 As shown, when the guide wire 2 is inserted below the knee in the reverse insertion method, the guide wire 2 often cannot be aligned with the center of the catheter 1, resulting in deviation in the connection. Even a slight deviation of the connected guide wire 2 and catheter 1 will result in failure to complete the connection. Summary of the invention

[0005] Based on this, a guidewire connecting guide tube is provided to solve the problem of how to improve the success rate and efficiency of guidewire reverse penetration.

[0006] The present application provides a guidewire-connected catheter, comprising:

[0007] Control handle;

[0008] A main pipe, comprising a main body section and a flared section, wherein the proximal end of the main body section is connected to the control handle, and the distal end of the main body section is connected to the proximal end of the flared section. A wire storage hole is provided in the pipe wall of the main pipe, and the flared section comprises an elastic outer layer, and the wire storage hole extends to the elastic outer layer;

[0009] The expansion control component includes a passive wire, an active wire, a traction wire and a rotating mechanism. The distal end of the passive wire is passed through the wire storage hole to the elastic outer layer. The passive wire is fixed to the inner wall of the wire storage hole located on the elastic outer layer. The distal end of the active wire is connected to the distal end of the passive wire. The rotating mechanism is arranged on the control handle and is used to pull the active wire through the traction wire.

[0010] In one embodiment, a plurality of wire storage holes are provided in the wall of the main pipe, each of the wire storage holes is provided with the active wire and the passive wire, a plurality of strands of the active wire are wound into one strand and connected to one end of the traction wire, and the other end of the traction wire is connected to the rotating mechanism.

[0011] In one embodiment, the flaring angle of the flaring section is 0°~90°, and / or the elastic outer layer includes a thermoplastic elastomer material.

[0012] In one embodiment, the rotating mechanism includes an active knob, a fixed knob, a passive knob and a movable screw, the active knob is coaxially connected to the fixed knob and can rotate relative to the fixed knob, the active knob is fixed to the passive knob, one side of the active knob and the fixed knob has a through hole, the through hole is used to place the movable screw and allows the movable screw to move axially, the movable screw is threadedly matched with the passive knob, and the distal end of the screw is connected to the traction wire.

[0013] In one embodiment, the guidewire-to-guide tube further includes a pressure control component, and the pressure control component is used to adjust the curvature of the main body segment according to the pressure change of the main body segment in the blood vessel.

[0014] In one embodiment, the pressure control component includes a liquid crystal dielectric elastomer, a current amplifier and a pressure sensor, and the liquid crystal dielectric elastomer, current amplifier and pressure sensor are all buried in the tube wall of the main segment. The pressure sensor is used to generate a current signal when the main segment is squeezed by the blood flow in the blood vessel, and the current amplifier is used to amplify the current signal from the pressure sensor, so that the liquid crystal dielectric elastomer is deformed and bent under the action of the current.

[0015] In one of the embodiments, the number of the pressure sensor and the number of the wire storage holes are both plural, and the pressure sensors are arranged in a one-to-one correspondence with the wire storage holes; and / or the pressure sensor includes a resistance strain gauge.

[0016] In one of the embodiments, the liquid crystal dielectric elastomer, current amplifier and pressure sensor are connected in series, and when the current amplified by the current amplifier is greater than or equal to a preset value, the liquid crystal dielectric elastomer deforms and returns to a bent state; when the current amplified by the current amplifier is less than a preset value, the liquid crystal dielectric elastomer remains in a straightened state.

[0017] In one embodiment, the liquid crystal dielectric elastomer is light-responsive, and the tube wall of the main section is also provided with an annular light strip. The liquid crystal dielectric elastomer is connected to the outside of the annular light strip, and the annular light strip is connected in series to the current amplifier and the pressure sensor, so that the current amplified by the current amplifier flows through the annular light strip. The annular light strip can emit ultraviolet light and visible light. Under ultraviolet light irradiation, the liquid crystal dielectric elastomer is deformed and returned to a bent state; under visible light irradiation or heating, the liquid crystal dielectric elastomer remains in a straightened state.

[0018] In one of the embodiments, it is characterized in that either, the annular light strip is connected in series with a switch, the switch is arranged on the control handle, and the switch is used to select the annular light strip to emit ultraviolet light or visible light; or, the luminous color of the annular light strip can be adjusted according to the current size, when the current is less than a threshold value, the annular light strip emits visible light, and when the current is greater than or equal to the threshold value, the annular light strip changes from visible light to ultraviolet light.

[0019] The above-mentioned guide wire connecting guide tube has a wire storage hole in the tube wall of the main tube, the flared section includes an elastic outer layer, the wire storage hole extends to the elastic outer layer, and the passive wire is fixed to the inner wall of the elastic outer layer where the wire storage hole is located. Therefore, when the guide wire needs to be connected, the knob mechanism of the control handle can be adjusted to pull the active wire through the traction wire, so that the active traction wire drives the passive wire to apply a pulling force toward the proximal end to the flared section, and the flaring angle of the flared section can be adjusted to improve the success rate of reverse penetration and shorten the reverse penetration time. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, drawings of other embodiments can be obtained based on these drawings without paying any creative work.

[0021] Figure 1 This is a schematic diagram showing that the guide wire is easily deviated from the catheter during the reverse penetration operation in the related art.

[0022] Figure 2 This is a schematic structural diagram of the guidewire connection catheter in Example 1 of the present application when the expanded section of the main tube is not expanded.

[0023] Figure 3 This is a structural schematic diagram of the expanded section of the main pipe in the guidewire connection catheter of Example 1 of the present application when expanded.

[0024] Figure 4 This is a schematic exploded view of a partial structure of the guidewire connected to the guide tube in Example 1 of the present application.

[0025] Figure 5 for Figure 4 The schematic diagram of the cross-sectional structure of the circled part of the main body section along the AA line in the guidewire-connected guide tube is shown.

[0026] Figure 6 for Figure 5 Schematic diagram of the cross-sectional structure along the CC line.

[0027] Figure 7 for Figure 4The cross-sectional structure schematic diagram of the expanded section along line BB in the guidewire-connected guide tube is shown.

[0028] Figure 8 This is a schematic diagram of the arrangement structure of the passive wire, the active wire and the traction wire in the main pipe in the guidewire connection catheter of Example 1 of the present application.

[0029] Fig. 9 for Figure 8 The guide wire is connected to the main pipe of the guide tube, and the flared section is expanded when the pulling wire applies a pulling force F to the active wire toward the proximal end.

[0030] Fig.10 This is a schematic diagram of the guidewire connection catheter of Example 1 of the present application using an expanded flared section to receive a reverse-threaded guidewire.

[0031] Fig.11 This is a circuit diagram of the pressure control component in the guidewire connection catheter of Example 1 of the present application.

[0032] Fig.12 This is a schematic diagram of the principle of deformation of the liquid crystal dielectric elastomer in the guidewire connection catheter of Example 1 as the current changes.

[0033] Fig.13 This is a structural schematic diagram of the guidewire connection guide tube provided in Examples 2 and 3 of the present application, in which the liquid crystal dielectric elastomer in the main section is arranged on the outside of the annular light strip.

[0034] Fig.14 This is a light source control circuit diagram in the pressure control assembly in the guidewire connection guide tube provided in Example 2 and Example 3.

[0035] Fig.15 This is a schematic diagram of the principle of deformation of the liquid crystal dielectric elastomer under light of different wavelengths in the guidewire connection guide tube provided in Examples 2 and 3 of the present application.

[0036] Reference numerals:

[0037] 1. catheter; 2. guide wire; 100. guide wire connected to guide tube; 101. stress diffusion tube; 102. Luer connector; 10. control handle; 11. handle housing; 111. first housing; 112. second housing; 12. hollow cover; 20. main tube; 21. main body section; 211. polymer outer layer; 22. flared section; 221. elastic outer layer; 23. wire storage hole; 30. flared control assembly; 31. passive wire; 32. active wire; 33 , traction wire; 34, rotating mechanism; 341, active knob; 341a, groove; 342, fixed knob; 343, passive knob; 344, movable screw; 40, pressure control component; 41, liquid crystal dielectric elastomer; 41a, cross-linking point; 41b, liquid crystal element; 42, current amplifier; 43, pressure sensor; 44, circuit board; 45, power supply; 46, switch; 47, wire; 48, LED screen; 49, ring light strip. DETAILED DESCRIPTION

[0038] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.

[0039] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be an intermediate element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be an intermediate element at the same time.

[0040] The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions are for illustrative purposes only and do not represent the only implementations.

[0041] It should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0042] It should be noted that "distal" and "proximal" are used as directional terms, which are commonly used terms in the field of interventional medical devices, where "distal" refers to the end away from the operator (such as the doctor) during the operation, and "proximal" refers to the end close to the operator during the operation. Axial refers to the direction in which the central axis of the medical device extends; radial refers to the direction perpendicular to the above-mentioned axial direction.

[0043] Example 1

[0044] Combination Figures 2 to 4 As shown, the embodiment of the present application provides a guide wire connecting guide tube 100, including a control handle 10, a main tube 20 and a flare control assembly 30. The proximal end of the main tube 20 is connected to the control handle 10. The control handle 10 is used to operate the flare control assembly 30 at the proximal end of the main tube 20, so that the flare control assembly 30 adjusts the distal opening size of the main tube 20.

[0045] For ease of understanding, the pipe section of the distal end of the main pipe 20 that can adjust the opening size is referred to as the "expanding section 22". Specifically, the main pipe 20 includes a main body section 21 and an expanding section 22. The proximal end of the main body section 21 is connected to the control handle 10, and the distal end of the main body section 21 is connected to the proximal end of the expanding section 22. In some embodiments, the expanding section 22 is welded to the main body section 21 by hot melting, so that the main body section 21 and the expanding section 22 are connected as a whole, ensuring the overall structural stability of the main pipe 20.

[0046] Combination Figures 5 to 7 As shown, a wire storage hole 23 is provided in the wall of the main pipe 20 . The wire storage hole 23 extends along the length direction of the main pipe 20 and penetrates from the main body section 21 to the expanded section 22 .

[0047] The number of the wire storage holes 23 can be 1, or 2 or more. When the number of the wire storage holes 23 is 2 or more, the wire storage holes 23 are evenly distributed along the circumference of the main pipe 20.

[0048] For the main pipe 20 with the wire storage hole 23, it can be obtained by extrusion molding with an extruder, or by multi-layer and multi-segment hot-melt welding of the conduit 1 through reflow welding. The manufacturing process of the main body segment 21 is not limited here.

[0049] Combination Figure 5 and Figure 6 As shown, the tube wall of the main body section 21 includes a polymer outer layer 211. The polymer outer layer 211 is an insulating material, and has certain flexibility and rigidity, which assists the catheter 1 to reach the lesion site. The material of the polymer outer layer 211 can be nylon or Pebax.

[0050] Combination Figure 7As shown, the expanded section 22 includes an elastic outer layer 221 , and the wire storage hole 23 extends to the elastic outer layer 221 .

[0051] Combination Figure 4 and Figure 5 As shown, the expansion control assembly 30 includes a passive wire 31 , an active wire 32 , a traction wire 33 and a rotating mechanism 34 .

[0052] Combination Figure 6 and Figure 8 As shown, the distal end of the passive wire 31 is passed through the elastic outer layer 221 along the wire storage hole 23, and the passive wire 31 is fixed to the inner wall of the wire storage hole 23 located at the elastic outer layer 221. In this way, when the passive wire 31 is subjected to a pulling force toward the proximal end, the elastic outer layer 221 will be elastically deformed under the traction of the passive wire 31, thereby adjusting the opening angle of the flared section 22, that is, the flaring angle.

[0053] The connection method between the passive wire 31 and the inner wall of the wire storage hole 23 includes but is not limited to hot melt connection or adhesive connection.

[0054] The distal end of the passive wire 31 is connected to the distal end of the active wire 32 , and the connection method includes but is not limited to welding. The multiple active wires 32 pass through the main tube 20 along the wire storage hole 23 to the control handle 10 to be connected to the rotating mechanism 34 .

[0055] The rotating mechanism 34 is disposed on the control handle 10 and is used to pull the active wire 32 by operating the pulling wire 33 , thereby adjusting the expanding angle of the expanding section 22 .

[0056] It should be noted that, in the embodiment in which there are multiple wire storage holes 23, each wire storage hole 23 is provided with an active wire 32 and a passive wire 31. That is to say, the number of active wires 32 and passive wires 31 can be configured to be consistent with the number of wire storage holes 23. For example, the active wire 32 is multiple strands, and the multiple strands of active wire 32 are wound around one strand and connected to one end of the traction wire 33, and the other end of the traction wire 33 is connected to the rotating mechanism 34 in the control handle 10. In this way, the active wire 32 can be operated to move along the wire storage hole 23 through the traction wire 33 by operating the rotating mechanism 34 in the control handle 10, thereby achieving the effect of controlling the flaring angle of the flaring section 22. For example, when the control handle 10 is operated so that the traction wire 33 is subjected to a pulling force toward the proximal end, the traction wire 33 drives the multiple strands of active wire 32 to withdraw toward the proximal end relative to the main pipe 20 at the same time. Since the active wire 32 and the passive wire 31 are connected at the distal end, and the passive wire 31 and the wire storage hole 23 are fixed to the inner wall of the flared section 22, the flared section 22 is in an open state under the action of the pulling force of the traction wire 33 toward the proximal end. It can be understood that the greater the traction wire 33 is withdrawn toward the proximal end, the larger the opening of the flared section 22 is.

[0057] In some embodiments, the expansion angle of the expansion section 22 is 0° to 90°. When the expansion angle of the expansion section 22 is 0°, it can be understood as the angle when the expansion section 22 is not expanded; when the expansion angle of the expansion section 22 is 90°, it can be understood as the opening angle of the expansion section 22 is 90°.

[0058] Combination Fig. 9 As shown, by operating the control handle 10 to apply a pulling force F toward the proximal end to the multiple active wires 32 through the traction wire 33, the flaring angle of the flaring section 22 can be adjusted so that the flaring section 22 changes within the range of 0° to 90°, so that the opening angle of the flaring section 22 is appropriate. For example, in some embodiments, the flaring angle of the flaring section 22 is 1°, 5°, 15°, 25°, 35°, 45°, 55°, 65°, 75°, 85° or 90°. The specific flaring angle of the flaring section 22 is not limited here.

[0059] Combination Fig.10 As shown, a suitable flaring angle can be adjusted based on the flaring section 22, so as to facilitate the introduction of the reverse penetration guide wire 2, thereby improving the reverse penetration success rate and shortening the reverse penetration time.

[0060] In some embodiments, the multiple active wires 32 and the traction wires 33 may be connected by welding. This welding method is not only convenient for the active wires 32 and the traction wires 33 to be connected, but also stable.

[0061] The elastic outer layer 221 may be a thermoplastic elastomer material, including but not limited to TPE or TPU. Preferably, a preset position of the elastic outer layer 221 is doped with a developing material for identifying the position of the catheter 1 under DSA (Digital Subtraction Angiography). The developing material may be BaSO4, Bi2O3 or W.

[0062] See again Figure 2 and Figure 3 As shown, in some embodiments, the guide wire connecting guide tube 100 includes a stress diffusion tube 101, which is sleeved on the main tube 20 and bonded to the control handle 10 to prevent the main tube 20 from bending during use. The material of the stress diffusion tube 101 includes but is not limited to silicone or TPU.

[0063] In some embodiments, the guide wire connecting guide tube 100 includes a Luer connector 102. The Luer connector 102 serves as a connection so that the guide wire connecting guide tube 100 can be used together with other devices. The Luer connector 102 and the main tube 20 can be connected by adhesive or pre-embedded injection molding. The material of the Luer connector 102 includes but is not limited to PC, Pebax or PP.

[0064] Combination Figure 4 As shown, the control handle 10 includes a handle housing 11 and a hollow cover 12 , and the hollow cover 12 is disposed at the distal end of the handle housing 11 .

[0065] The handle housing 11 includes a first housing 111 and a second housing 112. The shapes of the proximal ends of the first housing 111 and the second housing 112 match the shape of the Luer connector 102 so that the Luer connector 102 is fixed between the first housing 111 and the second housing 112. The overall shape of the handle housing 11 is ergonomic, thereby facilitating the gripping feeling when operating the control handle 10.

[0066] The material of the handle housing 11 includes but is not limited to PP, ABS, PC / ABS and the like.

[0067] Continue to combine Figure 4 As shown, the rotating mechanism 34 includes an active knob 341, a fixed knob 342, a passive knob 343 and a movable screw 344. The active knob 341 is coaxially connected to the fixed knob 342 and can rotate relative to the fixed knob 342. The active knob 341 and the passive knob 343 are fixed.

[0068] When the active rotary knob 341 rotates relative to the fixed knob 342 , the passive rotary knob 343 rotates along with the active rotary knob 341 and has the same rotation angle.

[0069] One side of the active knob 341 and the fixed knob 342 has a through hole for placing the movable screw 344 and allowing the movable screw 344 to move axially, thereby achieving the movable screw 344 moving toward the distal end or the proximal end.

[0070] The movable screw 344 is threadedly matched with the passive knob 343, and then the passive knob 343 can thread-drive the movable screw 344 to move axially when it rotates relative to the fixed knob 342. It should be noted that the surface of the movable screw 344 has an external thread, and the inner wall of the passive knob 343 is provided with an internal thread, and the internal thread is tightly meshed with the external thread, so that the movable screw 344 and the passive knob 343 are threadedly matched.

[0071] The distal end of the screw rod is connected to the traction wire 33. The distal end of the movable screw rod 344 and the traction wire 33 can be fixed by welding or connected by glue. The connection method between the movable screw rod 344 and the traction wire 33 is not limited here.

[0072] In this way, when the passive knob 343 rotates, it drives the active screw 344 to move toward the proximal end, so that the active screw 344 drives the traction wire 33 to move toward the proximal end. In this way, the traction wire 33 can be withdrawn toward the proximal end through the multiple active wires 32, and then the passive wire 31 applies a pulling force toward the proximal end to the flaring section 22 to adjust the flaring angle of the flaring section 22.

[0073] The material of the active knob 341 and the fixed knob 342 can be consistent with the material of the handle housing 11. For example, the material of the active knob 341 and the fixed knob 342 includes but is not limited to PP, ABS, and PC / ABS structure. In some embodiments, the passive knob 343 can also be made of a different material from the active knob 341. For example, the material of the passive knob 343 includes but is not limited to PEEK or PE.

[0074] The material of the movable screw 344 includes but is not limited to PC / ABS, ABS+glass fiber, etc., which is not limited here.

[0075] Continue to combine Figure 4 As shown, in some embodiments, a groove 341 a is provided on the active knob 341 , and the hollow cover 12 is connected to the groove 341 a on the active knob 341 to provide space for the movement of the traction wire 33 .

[0076] The fixing knob 342 may be threadedly matched with the handle housing 11. For example, the distal ends of the first housing 111 and the second housing 112 have a first thread structure, and the proximal end of the fixing knob 342 has a second thread structure. The first thread structure is meshed with the second thread structure, thereby connecting the fixing knob 342 to the distal ends of the first housing 111 and the second housing 112.

[0077] The connection method between the fixed knob 342 and the handle housing 11 is not limited to the above-mentioned threaded fit. For example, in some embodiments, the fixed knob 342 can also be connected to the handle housing 11 through a connection structure such as a buckle or a screw. The connection method between the fixed knob 342 and the handle housing 11 is not limited here.

[0078] Combination Figures 4 to 6 As shown, in some embodiments, the guidewire-connected catheter 100 further includes a pressure control component 40, which is used to adjust the curvature of the main body segment 21 according to the pressure change of the main body segment 21 in the blood vessel, so that the expanded section 22 at the distal end of the main body segment 21 tends to be located in the center of the blood vessel. In this way, it is convenient for the guidewire 2 to pass from the expanded section 22 into the main tube 20.

[0079] The pressure control assembly 40 includes a liquid crystal dielectric elastomer 41 , a current amplifier 42 and a pressure sensor 43 . The liquid crystal dielectric elastomer 41 , the current amplifier 42 and the pressure sensor 43 are all buried in the tube wall of the main body section 21 .

[0080] Combination Fig.11 As shown, the liquid crystal dielectric elastomer 41, the current amplifier 42 and the pressure sensor 43 are components of the pressure control component 40, and these components form a closed circuit for pressure display and controlling the bending of the main segment 21, etc.

[0081] Combination Fig.12 As shown, the liquid crystal dielectric elastomer 41 includes cross-linking points 41a and liquid crystal units 41b. The liquid crystal dielectric elastomer 41 is a high molecular polymer with shape memory formed by appropriately cross-linking a liquid crystal polymer.

[0082] The shape memory principle of the liquid crystal dielectric elastomer 41 is as follows: Fig.12 As shown, the liquid crystal dielectric elastomer 41 is oriented by external force, that is, the liquid crystal dielectric elastomer 41 is shaped and straightened, and the orientation is fixed after cooling, and the liquid crystal unit 41b is transformed into a single domain state. The liquid crystal dielectric elastomer 41 can be thermally responsive (i.e., it recovers when exposed to heat) or photoresponsive (i.e., it recovers when exposed to light). When subjected to different stimuli, such as the thermal effect or light effect caused by electric current, the liquid crystal unit 41b of the liquid crystal dielectric elastomer 41 will return to the multi-domain state, i.e., the deformation is recovered.

[0083] The liquid crystal dielectric elastomer 41, the current amplifier 42 and the pressure sensor 43 are connected in series. When the current amplified by the current amplifier 42 is greater than or equal to a preset value, the liquid crystal dielectric elastomer 41 deforms and returns to a bent state; when the current amplified by the current amplifier 42 is less than the preset value, the liquid crystal dielectric elastomer 41 remains in a straightened state.

[0084] Assuming that Imin is the minimum current value (i.e., the preset value) for the liquid crystal element 41b to change from a single-domain state to a multi-domain state, when the current I≥Imin, the liquid crystal dielectric elastomer 41 deforms and returns to a bent state; when the current I<Imin, the liquid crystal dielectric elastomer 41 remains in a straightened state.

[0085] It should be noted that the structure of the liquid crystal dielectric elastomer 41 can be a film or a fiber layer, which is not limited here.

[0086] There are multiple pressure sensors 43 and wire storage holes 23, and the pressure sensors 43 are arranged one by one with the wire storage holes 23. Thus, the blood pressure information outside the main tube 20 can be accurately received by using these pressure sensors 43.

[0087] It should be noted that the pressure sensor 43 is used to generate a current signal when the main body section 21 is squeezed by the blood flow in the blood vessel. The current amplifier 42 amplifies the current signal from the pressure sensor 43. In some embodiments, the pressure sensor 43 is a resistance strain type, that is, under the action of pressure, the resistance strain gauge embedded in the polymer outer layer 211 will undergo a slight deformation, resulting in a change in resistance value, thereby changing the current value, achieving the effect of deformation and bending of the liquid crystal dielectric elastomer 41. The material of the resistance strain gauge includes but is not limited to constantan or nickel-chromium wire.

[0088] Recombination Figure 4 As shown, in some embodiments, the pressure control assembly 40 includes a circuit board 44, a power supply 45, a switch 46, and a wire 47. The circuit board 44 and the power supply 45 are disposed in the handle housing 11 of the control handle 10, the switch 46 is mounted on the handle housing 11, and the operating portion of the switch 46 is exposed outside the handle housing 11, so as to facilitate the relevant control operations through the switch 46.

[0089] The circuit board 44 is made of PCB and is a carrier of circuits and other components. The power source 45 can be an alkaline dry cell, a lithium cell or a polymer cell, etc., preferably a lithium cell is used as the power source 45. The switch 46 includes but is not limited to a lighted push button switch, a self-locking switch or a common push button switch. The conductor 47 can be a multi-strand copper wire, and the multi-strand copper wire can be coated with an insulating outer layer.

[0090] The wire 47 connects the liquid crystal dielectric elastomer 41 , the current amplifier 42 , the pressure sensor 43 and the circuit board 44 to continuously supply power to these electronic components or transmit electrical signals.

[0091] Combination Figure 4 and Fig.11 As shown, in some embodiments, the pressure control assembly 40 further includes an LED screen 48. In this embodiment, the LED screen 48 is electrically connected to the current amplifier 42. The LED screen 48 is used to receive and display the current signal of the pressure sensor 43 amplified by the current amplifier 42.

[0092] For ease of understanding, the use process of the guidewire-connected guide tube 100 in one embodiment is described below, but it does not mean that the use process of the guidewire-connected guide tube 100 of the present application is limited to this.

[0093] When the guide wire is used to connect the catheter 100, physiological saline can be first injected into the main tube 20 through the Luer connector 102 to flush and heparinize the inner cavity of the main tube 20. When the catheter 1 reaches the lesion along the passage and cannot pass through, the reverse penetration method can be adopted to add an additional puncture point to penetrate the guide wire 2. After the guide wire 2 passes through the lesion, it merges with the catheter 1 to help establish the passage.

[0094] For example, in an embodiment of the present application, the switch 46 on the control handle 10 is turned on, and the pressure control component 40 starts working. In an embodiment in which the pressure control component 40 includes an LED screen 48, the pressure in all directions of the main tube 20 is displayed by the LED screen 48. The pressure is lower where the blood flow rate is faster, and the pressure is higher where the flow rate is slower. When the pressure in a certain direction increases, that is, the main tube 20 is offset, the pressure control component 40 controls the main tube 20 to bend so that the catheter 1 is always in the center position. By operating the active knob 341 on the control handle 10, the flaring section 22 begins to flare. The rotation angle of the active knob 341 can adjust the flaring angle of the flaring section 22, so that the flaring section 22 reaches a suitable flaring angle. After adjusting the flaring angle of the flaring section 22, the guide wire 2 for reverse penetration is more likely to pass through the flaring section 22 of the main tube 20 and enter the main tube 20, thereby shortening the reverse penetration time and improving the reverse penetration success rate.

[0095] There is no limitation on the specifications, quantity or material of each component in the guidewire-connected guide tube 100 , as long as they can adapt to the guidewire-connected guide tube 100 and play their corresponding functions and effects.

[0096] For ease of understanding, the structure of the guidewire-connected guide tube 100 is further described below.

[0097] In some embodiments, the guidewire connecting catheter 100 has a specification of 8F and an effective length of 1350 mm, and is suitable for connecting the retrograde guidewire 2 at the femoral popliteal position.

[0098] In some embodiments, the main tube 20 has an outer diameter of 2.67 mm, an inner diameter of 0.95 mm, and a length of 1500 mm, wherein the main body section 21 has a length of 1400 mm, and the flared section 22 has a length of 100 mm.

[0099] The number of wire storage holes 23 in the main body section 21 may be 4. The wire storage holes 23 are evenly distributed along the circumferential direction. The diameter of the wire storage holes 23 may be 0.45 mm. The wire storage holes 23 may penetrate the entire main pipe 20, or may only extend from the proximal end of the main pipe 20 to the flaring section 22. As long as the wire elements such as the passive wire 31, the active wire 32 or the traction wire 33 in the wire storage holes 23 can be used to tug the flaring section 22, the flaring operation of the flaring section 22 can be realized.

[0100] The wire 47 , the liquid crystal dielectric elastomer 41 , the current amplifier 42 and the pressure sensor 43 of the pressure control component 40 may be embedded in the polymer outer layer 211 , or may be arranged on the inner wall of the main body section 21 enclosed by the polymer outer layer 211 .

[0101] The number of the conducting wires 47 , the liquid crystal dielectric elastomer 41 , the current amplifier 42 and the pressure sensor 43 of the pressure control assembly 40 is consistent with the number of the wire storage holes 23 distributed along the circumferential direction.

[0102] In some embodiments, the overall single-side thickness of the main body section 21 does not exceed 300 um. The material of the polymer outer layer 211 may be Pebax5533, which has both rigidity and flexibility, and a single-side wall thickness of 100 um.

[0103] In some embodiments, the passive wire 31 has an outer diameter of 0.15 mm and a length of 1390 mm. It is pushed in from the distal end and combined with the bottom of the wire storage hole 23 by hot melt welding. The active wire 32 has an outer diameter of 0.25 mm and a length of 1420 mm. It passes through the 1390 mm catheter 1, with 30 mm exposed at the tail end, and the distal end is firmly welded to the passive wire 31.

[0104] The number of active wires 32 and passive wires 31 is consistent with the number of wire storage holes 23. For example, the tail ends of four active wires 32 are welded to the traction wire 33, and the traction wire 33 has an outer diameter of 0.40 mm and a length of 30 mm. The tail end of the traction wire 33 is connected to the control handle 10, and the traction wire 33 can be pulled back to expand the expansion section 22.

[0105] In some embodiments, the passive wire 31, the active wire 32 and the traction wire 33 are all made of 304 stainless steel. The elastic outer layer 221 is TPU, the developing material is W, and the doping ratio is 40%. The flaring section 22 is connected to the main section 21 by fusion welding.

[0106] The stress diffusion tube 101 is made of silicone, has a length of 20 mm, an outer diameter of 22.0 mm, an inner hole diameter of 2.80 mm, and is inserted from the far end of the main tube 20 to prevent the catheter 1 from bending under stress.

[0107] The Luer connector 102 is made of PC material, has an inner hole of 2.87 mm, and a hole depth of 10.0 mm. The Luer connector 102 is connected to the main pipe 20 by adhesive.

[0108] The control handle 10 has a length of 130 mm and a width of 50 mm. In the embodiment where the handle housing 11 includes a first housing 111 and a second housing 112 , the first housing 111 and the second housing 112 may have a wall thickness of 2.5 mm and a length of 90 mm.

[0109] In the embodiment where the rotating mechanism 34 includes an active knob 341, a fixed knob 342, a passive knob 343 and a movable screw 344. The active knob 341 has an outer diameter of 60 mm and a length of 20 mm, and has a pattern evenly distributed on the outer layer to prevent slipping during the rotation process.

[0110] In some embodiments, the liquid crystal dielectric elastomer 41 is a thermally responsive material, such as a carbon nanotube-doped gel, a metal-doped acrylic resin, etc. In this embodiment, the liquid crystal dielectric elastomer 41 is in a fiber form, and the single-side wall thickness can be 250um. The liquid crystal dielectric elastomer 41 is initially in a curved form, and the bending angle is 20° to 30°. At room temperature, the liquid crystal dielectric elastomer 41 is stretched and shaped. The liquid crystal element 41b is oriented along the axial direction.

[0111] Combination Fig. 9 As shown, when the switch 46 is pressed, the circuit starts to be powered on, the temperature of the liquid crystal dielectric elastomer 41 starts to rise, and when the current is greater than the threshold, the curved state is restored, and when the current is less than the threshold, the horizontal state is restored.

[0112] In some embodiments, the pressure sensor 43 is a resistance strain sensor, and the material of the resistance strain gauge can be nickel-chromium wire, and the structure is a wire strain gauge. When the blood vessel pressure increases, the resistance decreases and the current increases. The current amplifier 42 is connected to the liquid crystal dielectric elastomer 41 and the pressure sensor 43, and the current generated during the amplification process is made to reach the deformation threshold of the liquid crystal dielectric elastomer 41, and the amplified signal is transmitted to the LED screen 48 to reach the normal working current of the LED screen 48.

[0113] Example 2

[0114] The basic structure of the guide wire connecting guide tube 100 of Example 2 is consistent with that of the guide wire connecting guide tube 100 of Example 1. The difference is that Fig.13 As shown, in Embodiment 2, the tube wall of the main body section 21 of the main tube 20 is further provided with an annular light strip 49 .

[0115] The length of the annular light strip 49 is consistent with that of the liquid crystal dielectric elastomer 41. The liquid crystal dielectric elastomer 41 is connected to the outer side of the annular light strip 49, and the specific connection method includes but is not limited to gluing.

[0116] In some embodiments, the wall thickness of the annular light strip 49 is 50 um, and the wall thickness of the liquid crystal dielectric elastomer 41 is less than or equal to 250 um.

[0117] In Example 2, combined Fig.14As shown, the annular light strip 49 is connected in series to the current amplifier 42 and the pressure sensor 43, so that the current amplified by the current amplifier 42 flows through the annular light strip 49, and the annular light strip 49 can emit light of different wavelengths to illuminate the liquid crystal dielectric elastomer 41 to produce different deformations. For example, the annular light strip 49 can emit 365nm ultraviolet light and 460nm visible light. The liquid crystal dielectric elastomer 41 can be a light-responsive type. In this embodiment, the liquid crystal dielectric elastomer 41 is not directly connected to the circuit, but is connected to the outside of the annular light strip 49, and the annular light strip 49 is used to emit light to excite the liquid crystal dielectric elastomer 41 to produce deformation.

[0118] Combination Fig.15 As shown, under 365nm ultraviolet light irradiation, the liquid crystal dielectric elastomer 41 deforms and returns to a bent state; under 460nm visible light irradiation or heating, the liquid crystal dielectric elastomer 41 remains in a straightened state.

[0119] In some embodiments, the material of the liquid crystal dielectric elastomer 41 is an acrylic resin material with an azobenzene group. Thus, under 365nm ultraviolet light irradiation, the azobenzene group changes from a stable trans structure to a cis structure, driving the entire material to bend toward the light source; under 460nm visible light irradiation or heating, the material becomes straight again.

[0120] It should be noted that in this embodiment 2, the pressure control assembly 40 may also include a circuit board 44, a power supply 45, a switch 46 and a wire 47. The switch 46 is connected in series with the annular light strip 49. The switch 46 is provided on the control handle 10 and is used to select the annular light strip 49 to emit ultraviolet light or visible light.

[0121] The switch 46 can be a multi-mode lighted push button switch 46, and the color of the annular light strip 49 corresponds to the mode of the push button switch 46 one by one. Take the example that the annular light strip 49 can emit 365nm ultraviolet light and 460nm visible light. For example, the switch 46 is pressed once, the purple light source on the switch 46 lights up, and the annular light strip 49 emits ultraviolet light, and the wavelength can be 365nm. The switch 46 is pressed twice in succession, the purple light source on the switch 46 goes out, the green light source lights up, the ultraviolet light of the annular light strip 49 is turned off, and the visible light lights up, and the wavelength can be 460nm. The switch 46 is pressed three times in succession, and the light goes out. It should be noted here that continuously pressing the switch 46 is similar to double-clicking the switch 46, that is, the continuous here refers to repeatedly pressing the switch 46 within a very short preset time period. The preset time period can be specifically 0.5s~2s, which is not limited here.

[0122] Combination Fig.14As shown, in Example 2, the current amplifier 42, the pressure sensor 43 and the annular light strip 49 are connected in series to the switch 46. In this way, the doctor can operate the switch 46 to make the annular light strip 49 emit light of different colors according to the actual clinical situation and the display indication of the LED screen 48, so as to trigger the controllable bending of the liquid crystal dielectric elastomer 41, and then achieve the controllable bending operation of the main body section 21, so as to adjust the direction of the flared section 22, so as to facilitate the guide wire 2 to enter the main tube 20 from the flared section 22.

[0123] Example 3

[0124] The guidewire-connected guide tube 100 of Example 2 has the same basic structure as the guidewire-connected guide tube 100 of Example 2. Based on the current amplifier 42, the pressure sensor 43 and the annular light strip 49 being connected in series to the switch 46, the current amplifier 42 amplifies the current generated by the pressure sensor 43 due to deformation, and generates current in the entire circuit. The difference is that in Example 3, the luminous color of the annular light strip 49 can be adjusted according to the current size, so that there is no need to set the switch 46 as a multi-mode lighted button switch 46 to indicate the state of the liquid crystal dielectric elastomer 41 triggered by the annular light strip 49. When the current amplified by the current amplifier 42 is greater than or equal to the preset value, the liquid crystal dielectric elastomer 41 deforms and returns to a bent state; when the current amplified by the current amplifier 42 is less than the preset value, the liquid crystal dielectric elastomer 41 remains in a straightened state.

[0125] For example, when the current is less than the threshold value Imin, the annular light strip 49 is a visible light color, and the wavelength can be 460nm. At this time, the liquid crystal dielectric elastomer 41 is in a straightened state. When the current is greater than or equal to the threshold value Imin, the annular light strip 49 changes from visible light to ultraviolet light. The wavelength of ultraviolet light can be 360nm, at which time the liquid crystal dielectric elastomer 41 begins to bend, driving the main pipe 20 to return to the correct position. In this way, automatic bending control is achieved in Example 3. Therefore, the switch 46 can adopt a single-mode lighted button switch 46, or a multi-mode lighted button switch 46 in Example 2, and then the selection of the switch 46 in Example 3 is not limited.

[0126] In summary, the guidewire-connected catheter 100 according to the embodiment of the present application includes at least one of the following technical effects:

[0127] 1. Compared with the related art, when the doctor uses the corresponding sheath or guide tube as the catheter of the reverse guide wire, the inner diameter of the sheath and the guide tube is small, and it takes a long time for the reverse guide wire to merge through the catheter, and it is easy to fail to complete the docking due to the deviation of the guide wire and the catheter. The guide wire connecting guide tube 100 of the present application can be manually expanded to increase the inner diameter of the expanded section 22 at the distal end of the guide wire connecting guide tube 100, so as to facilitate the connection of the reverse guide wire 2, shorten the reverse time, and improve the reverse success rate.

[0128] 2. In view of the related art, the catheter is usually not centered during the intervention process, and the catheter position needs to be manually adjusted according to the DSA image during the introduction. The guidewire introduction catheter 100 provided in this application can adjust the position in real time according to the pressure changes in various positions in the blood vessel, so that the flared section 22 tends to be centered, which is more convenient for the guidewire 2 to penetrate.

[0129] 3. The control handle 10 is ergonomically designed and can be operated with one hand.

[0130] In this application, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0131] It should be noted that, in the embodiments of the present application, the terms "first" and "second" are used only for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of the present application, the meaning of "plurality" is at least two, for example, two, three, etc., unless otherwise clearly and specifically defined.

[0132] In the present application, unless otherwise clearly specified and limited, a first feature being “on” or “under” a second feature may mean that the first and second features are in direct contact with each other, or the first and second features are in indirect contact with each other through an intermediate medium.

[0133] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0134] The above embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the present application. It should be pointed out that, for a person of ordinary skill in the art, several modifications and improvements can be made without departing from the inventive concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the present application shall be subject to the attached claims.

Claims

1. A guide wire connected to a catheter, characterized in that: include: Control handle; A main pipe, comprising a main body section and a flared section, wherein the proximal end of the main body section is connected to the control handle, and the distal end of the main body section is connected to the proximal end of the flared section. A wire storage hole is provided in the pipe wall of the main pipe, and the flared section comprises an elastic outer layer, and the wire storage hole extends to the elastic outer layer; The expansion control component includes a passive wire, an active wire, a traction wire and a rotating mechanism. The distal end of the passive wire is passed through the wire storage hole to the elastic outer layer. The passive wire is fixed to the inner wall of the wire storage hole located on the elastic outer layer. The distal end of the active wire is connected to the distal end of the passive wire. The rotating mechanism is arranged on the control handle and is used to pull the active wire through the traction wire.

2. The guidewire-connecting catheter according to claim 1, characterized in that: A plurality of wire storage holes are arranged in the wall of the main pipe, each of which is provided with the active wire and the passive wire. The multiple active wires are wound into one strand and connected to one end of the traction wire, and the other end of the traction wire is connected to the rotating mechanism.

3. The guidewire-connecting catheter according to claim 1 or 2, characterized in that: The flaring angle of the flaring section is 0° to 90°, and / or the elastic outer layer comprises a thermoplastic elastomer material.

4. The guidewire-connecting catheter according to claim 3, characterized in that: The rotating mechanism includes an active knob, a fixed knob, a passive knob and a movable screw. The active knob is coaxially connected to the fixed knob and can rotate relative to the fixed knob. The active knob is fixed to the passive knob. One side of the active knob and the fixed knob has a through hole, which is used to place the movable screw and allows the movable screw to move axially. The movable screw is threadedly matched with the passive knob, and the distal end of the screw is connected to the traction wire.

5. The guidewire-connected catheter according to claim 1, characterized in that: The guidewire-connected guide tube further comprises a pressure control component, and the pressure control component is used to adjust the curvature of the main body segment according to the pressure change of the main body segment in the blood vessel.

6. The guidewire-connecting catheter according to claim 5, characterized in that: The pressure control component includes a liquid crystal dielectric elastomer, a current amplifier and a pressure sensor, and the liquid crystal dielectric elastomer, the current amplifier and the pressure sensor are all buried in the tube wall of the main section. The pressure sensor is used to generate a current signal when the main section is squeezed by the blood flow in the blood vessel, and the current amplifier is used to amplify the current signal from the pressure sensor, so that the liquid crystal dielectric elastomer is deformed and bent under the action of the current.

7. The guidewire-connected catheter according to claim 6, characterized in that: The number of the pressure sensors and the wire storage holes are both multiple, and the pressure sensors are arranged in a one-to-one correspondence with the wire storage holes; And / or, the pressure sensor includes a resistance strain gauge.

8. The guidewire-connecting catheter according to claim 6 or 7, characterized in that: The liquid crystal dielectric elastomer, current amplifier and pressure sensor are connected in series. When the current amplified by the current amplifier is greater than or equal to a preset value, the liquid crystal dielectric elastomer deforms and returns to a bent state; when the current amplified by the current amplifier is less than the preset value, the liquid crystal dielectric elastomer remains in a straightened state.

9. The guidewire-connecting catheter according to claim 6 or 7, characterized in that: The liquid crystal dielectric elastomer is light-responsive, and the tube wall of the main section is also provided with an annular light strip. The liquid crystal dielectric elastomer is connected to the outside of the annular light strip, and the annular light strip is connected in series to the current amplifier and the pressure sensor, so that the current amplified by the current amplifier flows through the annular light strip. The annular light strip can emit ultraviolet light and visible light. Under ultraviolet light irradiation, the liquid crystal dielectric elastomer is deformed and restored to a bent state; under visible light irradiation or heating, the liquid crystal dielectric elastomer remains in a straightened state.

10. The guidewire-connected catheter according to claim 9, characterized in that Alternatively, the annular light strip is connected in series with a switch, the switch is arranged on the control handle, and the switch is used to select the annular light strip to emit ultraviolet light or visible light; Alternatively, the luminous color of the annular light strip can be adjusted according to the current size. When the current is less than a threshold value, the annular light strip emits visible light. When the current is greater than or equal to the threshold value, the annular light strip changes from visible light to ultraviolet light.

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