Preparation system and method of nutrient nano-emulsion

Abstract

The invention relates to a preparation system and method of a nutrient nano-emulsion. The preparation system of the nutrient nano-emulsion comprises an ingredient homogenizing tank, a storage tank, a stirring device, a vacuum pipeline, a negative pressure pipeline and a nitrogen pipeline, the ingredient homogenizing tank is provided with a gas inlet suitable for being connected with a nitrogen pipeline so as to introduce nitrogen into the ingredient homogenizing tank, and a feeding hole suitable for putting an original material into the ingredient homogenizing tank; the stirring end of the stirring device extends into the cavity of the ingredient homogenizing tank; a discharge port is further formed in the batching and homogenizing tank, the discharge port is connected with an inlet of the storage tank through a negative pressure pipeline, and materials are suitable for flowing into the storage tank through the negative pressure pipeline; more than two ball valves are arranged on the negative pressure pipeline; one end of the vacuum pipeline is communicated with the interior of the cavity of the storage tank, and the vacuum pump is suitable for pumping air in the storage tank and the negative pressure pipeline through the vacuum pipeline. Based on the physical preparation principle, no organic solvent is used in the preparation process, and no pollutant is discharged.

Description

Technical Field

[0001] The present application relates to the field of food processing technology, and in particular to a system and method for preparing a nutrient nanoemulsion. Background Art

[0002] In the field of food, especially beverage processing, it is usually necessary to convert lipophilic or fatty substances into the form of nanoemulsions that are easy to apply. Transparent to translucent nanoemulsifiers are required for special applications. Such products are generally transparent preparations obtained by dissolving lipophilic or fatty substances with emulsifiers, co-emulsifiers and solvents.

[0003] In the prior art of preparing transparent nanoemulsions, only surfactants are used to dissolve fatty substances into a transparent system. Reference may be made to the Chinese patent with publication number CN114307708B, which is a method for continuously preparing drug-loaded nanoemulsions; the technology dissolves the drug into an organic solvent, and the obtained solution is used as the oil phase and loaded into an oil phase storage tank; an aqueous solution of a surfactant is used as the water phase and loaded into a water phase storage tank; a high-precision injection pump is turned on to drive the oil phase and the water phase into a T-tube for emulsification to obtain a drug-loaded nanoemulsion; and the organic solvents used therein are n-butanol, n-pentanol, n-hexanol, chloroform, dichloromethane, ethyl acetate, phenol, benzyl alcohol, phenylethyl alcohol, phenylpropanol or benzene; however, some organic solvents are strong cytotoxics, and at the same time, due to their strong volatility, they are not conducive to environmental protection. Summary of the invention

[0004] In view of this, the present application proposes a system and method for preparing nutrient nanoemulsions.

[0005] According to one aspect of the present application, a system for preparing a nutrient nanoemulsion is provided, comprising: a batching homogenization tank, a storage tank, a stirring device, a vacuum pipeline, a negative pressure pipeline with a ball valve, and a nitrogen pipeline;

[0006] The batching homogenizing tank is provided with an air inlet suitable for connecting with a nitrogen pipeline to introduce nitrogen into the batching homogenizing tank, and a feed inlet suitable for putting the original material into the batching homogenizing tank;

[0007] The stirring end of the stirring device is inserted into the cavity of the batching homogenizing tank;

[0008] The batching homogenizing tank is also provided with a discharge port, which is connected to the inlet of the storage tank through a negative pressure pipe, and the material is suitable for flowing into the storage tank through the negative pressure pipe with a ball valve; more than two ball valves are arranged in sequence along the direction of material flow in the negative pressure pipe;

[0009] One end of the vacuum pipe is communicated with the interior of the cavity of the storage tank, and the vacuum pump is suitable for extracting air in the storage tank and the negative pressure pipe through the vacuum pipe.

[0010] In a possible implementation, a nitrogen pressure regulating valve is provided on the nitrogen pipeline, which is suitable for regulating the pressure in the batching homogenizing tank through the nitrogen pressure regulating valve.

[0011] In a possible implementation, an observation window is provided on the side wall of the batching homogenizing tank.

[0012] In a possible implementation, the negative pressure pipeline is provided with a first valve, and the first valve is located between the discharge port of the batching homogenization tank and the ball valve.

[0013] In a possible implementation, three ball valves are provided on the negative pressure pipeline.

[0014] In a possible implementation, all three ball valves are ceramic ball valves.

[0015] In a possible implementation, a splash shield is provided at one end of the negative pressure pipe that extends into the cavity of the storage tank.

[0016] In a possible implementation, a discharge pipe is provided at the outlet of the storage tank, and a second valve and a discharge pump are provided on the discharge pipe.

[0017] According to another aspect of the present application, a method for preparing a nutrient nanoemulsion is provided, which is prepared using a preparation system for a nutrient nanoemulsion, comprising:

[0018] Putting the raw materials into a nitrogen-filled ingredient homogenizing tank according to a preset procedure, wherein the raw materials include fat-soluble nutrients, emulsifiers and polyol solutions, and the ratio of the fat-soluble nutrients, emulsifiers and polyol solutions is a preset ratio;

[0019] Controlling the stirring device to stir the original material to obtain a preliminarily homogeneous suspension liquid;

[0020] The pressure in the batching homogenizing tank is adjusted to a first preset pressure, and the storage tank and the negative pressure pipeline are evacuated through a vacuum pipeline so that the pressure in the storage tank and the negative pressure pipeline reaches a second preset pressure, so that the preliminarily homogenized suspension liquid flows into the negative pressure pipeline through the discharge port of the batching homogenizing tank under the extrusion of pressure and is transported to the storage tank;

[0021] Before the preliminarily homogenized suspension liquid flows into the negative pressure pipe through the discharge port of the batching homogenization tank under the extrusion of pressure, the ball valve in the negative pressure pipe is controlled to reach a preset opening, so that the preliminarily homogenized suspension liquid entering the negative pressure pipe is sheared and impacted by the ball valve to obtain a nutrient nanoemulsion.

[0022] In a possible implementation, when the ball valves in the negative pressure pipeline are controlled to reach a preset opening, the openings of all ball valves are the same.

[0023] Beneficial effects: the batching homogenizing tank is suitable for placing the original materials to be homogenized (fat-soluble nutrients, emulsifiers, polyol solutions); the stirring device is suitable for stirring the original materials in the batching homogenizing tank so that the original materials of each component are evenly mixed and form a suspended liquid. When the liquid material flows through the ball valve on the negative pressure pipeline, the components in the material will be sheared and impacted by the opening of the ball valve, and when the instantaneous pressure in the negative pressure pipeline is instantly reduced, the surface tension of the molecules decreases, thereby causing the fat globules in the liquid to rupture and form a nanoemulsion with uniform particle size with the added emulsifier and polyol solution. After the liquid material flows through multiple ball valves in turn, repeated shearing, impact and fusion make the nanoemulsion particle size distribution finally collected in the storage tank more uniform. The preparation system of the nutrient nanoemulsion proposed in this application can realize the preparation of the nanoemulsion based on the physical preparation principle, and the preparation process is simple, which can solve the problem of complicated preparation procedures in the prior art. No additives need to be added during the preparation process, no organic solvents are used, and no pollutants are discharged.

[0024] Other features and aspects of the present application will become apparent from the following detailed description of exemplary embodiments with reference to the attached drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate exemplary embodiments, features, and aspects of the present application and, together with the description, serve to explain the principles of the present application.

[0026] Figure 1 A structural diagram of a system for preparing a nutrient nanoemulsion according to an embodiment of the present application is shown. DETAILED DESCRIPTION

[0027] Various exemplary embodiments, features and aspects of the present application will be described in detail below with reference to the accompanying drawings. The same reference numerals in the accompanying drawings represent elements with the same or similar functions. Although various aspects of the embodiments are shown in the accompanying drawings, the drawings are not necessarily drawn to scale unless otherwise specified.

[0028] Among them, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application or simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0029] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of this application, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0030] The word “exemplary” is used exclusively herein to mean “serving as an example, example, or illustration.” Any embodiment described herein as “exemplary” is not necessarily to be construed as preferred or advantageous over other embodiments.

[0031] In addition, in order to better illustrate the present application, numerous specific details are given in the following specific embodiments. It should be understood by those skilled in the art that the present application can also be implemented without certain specific details. In some examples, methods, means, components and circuits well known to those skilled in the art are not described in detail in order to highlight the subject matter of the present application.

[0032] Figure 1 The structural diagram of a system for preparing a nutrient nanoemulsion according to an embodiment of the present application is shown. Figure 1 As shown, the preparation system of the nutrient nanoemulsion comprises: a batching homogenizing tank 100, a storage tank 500, a stirring device, a vacuum pipe 600, a negative pressure pipe 400 and a nitrogen pipe 200; the batching homogenizing tank 100 is provided with an air inlet suitable for connecting with the nitrogen pipe 200 to introduce nitrogen into the batching homogenizing tank 100, and a feed inlet 110 suitable for putting the original material into the batching homogenizing tank 100; the stirring end of the stirring device is inserted into the cavity of the batching homogenizing tank 100; the batching homogenizing tank 100 is also provided with a vacuum pipe 600, a negative pressure pipe 400 and a nitrogen pipe 200; the vacuum pipe 600 is provided with a vacuum pipe 4 ... A discharge port is provided, which is connected to the inlet of the storage tank 500 through the negative pressure pipe 400, and the material is suitable for flowing into the storage tank 500 through the negative pressure pipe 400; more than two ball valves 420 are provided on the negative pressure pipe 400; the more than two ball valves 420 are arranged in sequence along the direction of material flow in the negative pressure pipe 400; one end of the vacuum pipe 600 is connected to the interior of the cavity of the storage tank 500, and the vacuum pump 610 is suitable for extracting air in the storage tank 500 and the negative pressure pipe 400 through the vacuum pipe 600.

[0033] Here, it should be noted that the batching homogenizing tank 100 is suitable for placing the original materials to be homogenized (fat-soluble nutrients, emulsifiers, polyol solutions); the stirring device is suitable for stirring the original materials in the batching homogenizing tank 100 so that the original materials of each component are evenly mixed to obtain a preliminarily homogenized suspension liquid, and the negative pressure pipe 400 is used as a connecting pipe between the batching homogenizing tank 100 and the storage tank 500. Under the positive pressure applied by the nitrogen in the batching homogenizing tank 100 and the negative pressure applied by the vacuum pump, the preliminarily homogenized suspension liquid can enter the storage tank 500 from the negative pressure pipe 400, and at the same time, when the preliminarily homogenized suspension liquid flows through the negative pressure pipe 400 When the ball valve 420 on the upper part is opened, the components in the material will be sheared and impacted by the opening of the ball valve 420, and when the instantaneous pressure is instantly reduced when flowing through the negative pressure pipe 400, the surface tension of the molecules decreases, thereby causing the fat globules in the liquid to rupture and form a nanoemulsion with uniform particle size with the added emulsifier and polyol solution. Here, it should be noted that the opening of the ball valve 420 directly affects the formation and particle size of the nanoemulsion. The smaller the opening of the ball valve 420, the smaller the particle size of the nanoemulsion; but if the opening of the ball valve 420 is too small, the efficiency will be reduced, and if the opening of the ball valve 420 is too large, the particle size of the nanoemulsion will be too large and uneven. After the initially homogenized suspension liquid flows through multiple ball valves 420 in sequence, repeated shearing, impact and fusion make the nutrient nanoemulsion finally collected in the storage tank 500 smaller in particle size and more evenly distributed. The preparation system of the nutrient nanoemulsion proposed in the present application can realize the preparation of the nutrient nanoemulsion based on the physical preparation principle, and the preparation process is simple, which can solve the problem of complicated preparation procedures in the prior art. In the preparation process of the present application, only food raw materials are used, no additives are added, no organic solvents are used, and no pollutants are discharged.

[0034] Preferably, the air inlet and the feed inlet 110 of the batching and homogenizing tank 100 are both arranged at the top of the batching and homogenizing tank 100 ; and the discharge port is arranged at the bottom of the batching and homogenizing tank 100 .

[0035] In a possible implementation, a nitrogen pressure regulating valve 210 is provided on the nitrogen pipeline 200. Figure 1 As shown, one end of the nitrogen pipeline 200 is connected to the nitrogen bottle 220, and the other end of the nitrogen pipeline 200 is connected to the air inlet of the batching homogenizing tank 100. The nitrogen pressure regulating valve 210 can be adjusted to conduct and stop the injection of nitrogen; at the same time, the pressure in the batching homogenizing tank 100 can be adjusted by adjusting the nitrogen pressure regulating valve 210. It should be noted that the specific model of the nitrogen pressure regulating valve 210 is not limited in this application, as long as the low pressure gauge range is 0-10MPa.

[0036] In one possible implementation, the stirring device includes: a motor 300, a stirring rod 310 and blades 320; the output shaft of the motor 300 is connected to the stirring rod 310, suitable for driving the stirring rod 310 to rotate, and the other end of the stirring rod 310 is provided with a plurality of blades 320, and the blades 320 are located inside the cavity of the batching homogenizing tank 100. When the stirring rod 310 rotates, the blades 320 are driven to rotate inside the batching homogenizing tank 100, thereby stirring the original material in the batching homogenizing tank 100.

[0037] Furthermore, the stirring rod 310 and the blade 320 are both made of food-grade stainless steel.

[0038] In a possible implementation, an observation window 120 is provided on the side wall of the batching homogenizing tank 100. It should be noted that in order to facilitate observation of the content of the preliminary homogenized suspension liquid in the batching homogenizing tank 100, an observation window 120 is provided on the side wall near the bottom of the batching homogenizing tank 100. When the liquid level in the batching homogenizing tank 100 reaches the observation window 120, it means that the preliminary homogenized suspension liquid in the batching homogenizing tank 100 is about to flow out, and the preparation process can be stopped at this time.

[0039] Furthermore, the observation window 120 is made of tempered glass.

[0040] In a possible implementation, the volume below the observation window 120 of the batching and homogenizing tank 100 accounts for 1% to 5% of the total volume of the batching and homogenizing tank 100 .

[0041] In a possible implementation, the negative pressure pipeline 400 is provided with a first valve 410; the first valve 410 is located between the discharge port of the batching homogenization tank 100 and the ball valve 420. The first valve 410 is configured to control the on-off of the negative pressure pipeline 400 to prevent materials that have not been mixed uniformly from flowing into the negative pressure pipeline 400. Furthermore, the first valve 410 is a stop valve.

[0042] In a possible implementation, according to the foregoing, more than two ball valves are provided in the negative pressure pipeline, wherein each ball valve is fixed in the negative pressure pipeline by using the same mounting structure.

[0043] Furthermore, three ball valves 420 may be provided on the negative pressure pipe 400. Meanwhile, the three ball valves 420 are all ceramic ball valves 420, and preferably the ball valve 420 is a ceramic lined ball valve with an opening indicator.

[0044] At the same time, it should be pointed out that Figure 1 As shown, in order to more effectively form shear and impact, the negative pressure pipe 400 is a double U-shaped structure, the first ball valve 420 is installed below the first valve 410, the second ball valve 420 is installed in the middle of the bottom section of the first U-shape, and the third ball valve 420 is installed in the middle of the inverted U-shaped top section.

[0045] In a possible implementation, one end of the negative pressure pipe 400 is inserted into the cavity of the storage tank 500, and a splash shield 430 is provided at the end of the negative pressure pipe 400 that is inserted into the cavity of the storage tank 500. The splash shield 430 is a conical structure, which is sleeved on the outside of the negative pressure pipe 400. The setting of the splash shield 430 prevents the nutrient nanoemulsion sprayed from the negative pressure pipe 400 from splashing in the storage tank 500, which is conducive to the collection of the nutrient nanoemulsion.

[0046] In a possible implementation, the outlet of the storage tank 500 is provided with a discharge pipe, and the discharge pipe is provided with a second valve 510 and a discharge pump 520. The second valve 510 is suitable for controlling the on-off of the discharge pipe, and the setting of the discharge pump 520 is suitable for sucking out the nutrient nanoemulsion in the storage tank 500 to speed up the flow rate of the nutrient nanoemulsion. Further, the second valve 510 is a stop valve.

[0047] In one possible implementation, one end of the vacuum pipe 600 is connected to the interior of the cavity of the storage tank 500, and the other end of the vacuum pipe 600 is provided with a vacuum pump 610. The vacuum pump 610 is suitable for sucking out the gas in the storage tank 500 and the negative pressure pipe 400 through the vacuum pipe 600, so that a negative pressure state is formed in the storage tank 500 and the negative pressure pipe 400, so that the material liquid can quickly flow into the storage tank 500 from the negative pressure pipe 400.

[0048] In a possible implementation, it further includes: an air pressure balance pipe 630; the air pressure balance pipe 630 is connected to the vacuum pipe 600, and a vent valve 640 is provided on the air pressure balance pipe 630; it should be noted that when all the materials fall into the storage tank 500, the vent valve 640 is opened, and air enters the storage tank 500 from the air pressure balance pipe 630, so that the negative pressure state in the storage tank 500 disappears, thereby ensuring that the materials can flow out of the storage tank 500. Further, the vent valve 640 is a stop valve.

[0049] In a possible implementation, it also includes: a first vacuum gauge 440 , which is disposed on the negative pressure pipeline 400 and located between two adjacent ball valves 420 , and is suitable for detecting the pressure in the negative pressure pipeline 400 .

[0050] In a possible implementation, it also includes: a second vacuum gauge 620 ; the second vacuum gauge 620 is disposed on the vacuum pipe 600 and is suitable for detecting the gas pressure in the storage tank 500 .

[0051] Preferably, the ratio of the volume of the batching homogenizing tank 100 to the volume of the storage tank 500 is 1:3. Both the batching homogenizing tank 100 and the storage tank 500 are ceramic-lined stainless steel pressure-resistant tanks.

[0052] A method for preparing a nutrient nanoemulsion is prepared using the above-mentioned nutrient nanoemulsion preparation system, comprising: placing raw materials into a batching homogenization tank 100 filled with nitrogen according to a preset procedure, wherein the raw materials include fat-soluble nutrients, emulsifiers and polyol solutions, and the ratio of the fat-soluble nutrients, emulsifiers and polyol solutions is a preset ratio; controlling a stirring device to stir the raw materials until a preliminarily homogenized suspension liquid is obtained; then adjusting the pressure in the batching homogenization tank 100 to a first preset pressure, and applying a vacuum pipe 600 to a storage tank 500 and a negative pressure pipe 400. Vacuum is performed to make the pressure in the storage tank 500 and the negative pressure pipe 400 reach a second preset pressure, so that the preliminarily homogenized suspension liquid flows into the negative pressure pipe 400 under the extrusion of pressure through the discharge port of the batching homogenizing tank 100 and is transported to the storage tank 500; wherein, before the preliminarily homogenized suspension liquid flows into the negative pressure pipe 400 under the extrusion of pressure through the discharge port of the batching homogenizing tank 100, the ball valve 420 located in the negative pressure pipe 400 is controlled to reach a preset opening, so that the homogenized suspension liquid in the negative pressure pipe 400 is sheared and impacted by the ball valve 420 to obtain the nutrient nanoemulsion.

[0053] Before preparation, it is necessary to ensure that the batching homogenizing tank 100, the material storage tank 500 and the negative pressure pipe 400 are dry and clean.

[0054] Preferably, the rotation speed of the stirring rod is 500 rpm; and the stirring time is between 15 and 30 minutes.

[0055] In a possible implementation, when the pressure in the batching homogenizing tank 100 is adjusted to the first preset pressure, the pressure is adjusted by the nitrogen pressure regulating valve 210. Preferably, the value range of the first preset pressure is 2MPa to 5MPa.

[0056] Preferably, after adjusting the pressure in the ingredient homogenizing tank 100 to a first preset pressure, the ball valve 420 located in the negative pressure pipe 400 is controlled to reach a preset opening. After controlling the ball valve 420 located in the negative pressure pipe 400 to reach a preset opening, the storage tank 500 and the negative pressure pipe 400 are evacuated through the vacuum pipe 600.

[0057] In a possible implementation, when the vacuum pipe 600 evacuates the storage tank 500 and the negative pressure pipe 400, the pressure in the storage tank 500 and the negative pressure pipe 400 reaches a second preset pressure. Preferably, the second preset pressure has a value range of 0.02MPa to 0.05MPa.

[0058] In a possible implementation, when the ball valve 420 in the negative pressure pipe 400 is controlled to reach a preset opening, the openings of all ball valves 420 are the same; preferably, the preset opening range is 5% to 10% of the fully open state of the ball valve 420.

[0059] In a possible implementation, when the vacuum pipe 600 evacuates the storage tank 500 and the negative pressure pipe 400 , the pressure in the storage tank 500 is obtained through the first vacuum gauge 440 ; and the pressure in the negative pressure pipe 400 is obtained through the second vacuum gauge 620 .

[0060] In a possible implementation, the first valve 410 is opened before the preliminary homogenized suspension liquid flows into the negative pressure pipe 400 through the discharge port of the batching homogenization tank 100 .

[0061] In a possible implementation, before the nutrient nanoemulsion flows out of the storage tank 500, the first valve 410 is closed, the vacuum pump 610 is turned off, and the vent valve 640 is opened to eliminate the negative pressure in the storage tank 500; then, the discharge valve and the unloading pump 520 are opened to allow the nutrient nanoemulsion to flow out of the storage tank 500.

[0062] It should be noted that the ratio of fat-soluble nutrients to emulsifiers depends on the properties of the fat-soluble nutrients to be embedded and the requirements for the particle size of the formed nanoemulsion, and the polyol solution is only a solvent.

[0063] In summary, fat-soluble nutrients, emulsifiers and polyol solutions in preset proportions are placed into a batching homogenizing tank 100 filled with nitrogen according to a preset procedure, and a stirring device stirs the three materials until the three materials are evenly mixed to obtain a preliminarily homogeneous suspension liquid; then the nitrogen pressure regulating valve 210 on the nitrogen pipeline 200 is adjusted to make the pressure in the batching homogenizing tank 100 reach a first preset pressure; then the ball valve 420 located in the negative pressure pipeline 400 is controlled to reach a preset opening, and the openings of all ball valves 420 are the same; then the vacuum pump 610 is turned on, and the vacuum pump 610 evacuates the storage tank 500 and the negative pressure pipeline 400 through the vacuum pipeline 600, Make the pressure in the negative pressure pipe 400 and the storage tank 500 reach the second preset pressure; then open the first valve 410, so that the initially homogenized suspension liquid flows into the negative pressure pipe 400 through the discharge port of the batching homogenizing tank 100 under the extrusion of pressure, and flows through more than two ball valves 420 in sequence and finally gathers in the storage tank 500; after the liquid level of the initially homogenized suspension liquid in the batching homogenizing tank 100 reaches below the observation window 120, close the first valve 410 and the vacuum pump 610 in sequence, open the vent valve 640, and then open the second valve 510 and the unloading pump 520, and the nutrient nanoemulsion is discharged through the second valve 510 and the unloading pump 520.

[0064] The following is a further explanation of the use of the system in conjunction with four specific application examples:

[0065] Example 1

[0066] The fat-soluble nutrient is vitamin E acetate, the gram weight is 1500g; the emulsifier is soybean lecithin with a phosphatidylcholine content of 75%, the gram weight is 300g; the polyol solution is 8200g edible glycerin (containing 200g of water);

[0067] The first preset pressure is set to 5MPa; the second preset pressure is set to 0.05MPa;

[0068] 300g of soybean lecithin with a phosphatidylcholine content of 75%, 8200g of glycerol with a water content of 200g, and 1500g of vitamin E acetate are added to the batching homogenization tank 100 through the feed port 110, the nitrogen pressure regulating valve 210 is opened to introduce nitrogen, and then the stirring device is turned on to stir the three materials at a speed of 500 rpm for 20 minutes to form a uniform suspension liquid; then the nitrogen pressure regulating valve 210 on the nitrogen pipeline 200 is adjusted to make the pressure in the batching homogenization tank 100 reach 5MPa; then the opening of all ball valves 420 is set to 5% of the fully open state; then the vacuum pump 610 is turned on, and the vacuum pump 610 is used to pump the storage tank 500 through the vacuum pipeline 600. Vacuum the negative pressure pipe 400 and the storage tank 500 to a pressure of 0.05 MPa; then open the first valve 410 to allow the initially homogenized suspension to flow into the negative pressure pipe 400 and sequentially flow through more than two ball valves 420 to finally be collected in the storage tank 500 to obtain the nutrient nanoemulsion; after the liquid level of the initially homogenized suspension in the batching homogenization tank 100 reaches below the observation window 120, close the first valve 410 and the vacuum pump 610 in sequence, open the vent valve 640, and then open the second valve 510 and the unloading pump 520, the nutrient nanoemulsion is discharged through the second valve 510 and the unloading pump 520, and the nutrient nanoemulsion is packaged in a sterile container; the particle size distribution of the nutrient nanoemulsion is shown in Table 1.

[0069]

[0070] Table 1

[0071] The pressure difference in Table 1 refers to the difference between the first preset pressure in the batching homogenization tank 100 and the second preset pressure in the storage tank 500; the particle size corresponding to the cumulative particle size distribution percentage in the sample reaching 50% is 239nm, which can characterize the average particle size of the nutrient nanoemulsion. The particle size corresponding to the cumulative particle size distribution percentage in the sample reaching 75% is 507nm; the particle size corresponding to the cumulative particle size distribution percentage in the sample reaching 90% is 861nm; this value reflects the particle size of the larger particles in the sample.

[0072] Example 2

[0073] The fat-soluble nutrient is vitamin E acetate, the gram weight is 1500g; the emulsifier is soybean lecithin with a phosphatidylcholine content of 75%, the gram weight is 300g; the polyol solution is 8200g edible glycerin (containing 200g of water);

[0074] The first preset pressure is set to 2MPa; the second preset pressure is set to 0.02MPa;

[0075] 300g of soybean lecithin with a phosphatidylcholine content of 75%, 8200g of glycerol with a water content of 200g, and 1500g of vitamin E acetate are added to the batching homogenizing tank 100 through the feed port 110, and the nitrogen pressure regulating valve 210 is opened to introduce nitrogen, and then the stirring device stirs the three materials until the three materials are evenly mixed to obtain a preliminarily homogeneous suspension liquid; then the nitrogen pressure regulating valve 210 on the nitrogen pipeline 200 is adjusted to make the pressure in the batching homogenizing tank 100 reach 2MPa; then the opening of all ball valves 420 is set to 10% of the fully open state; then the vacuum pump 610 is turned on to make the negative pressure pipeline 400, the storage The pressure in the material tank 500 reaches 0.02MPa; then the first valve 410 is opened to allow the initially homogenized suspension liquid to flow into the negative pressure pipe 400 and flow through more than two ball valves 420 in sequence and finally converge into the storage tank 500 to obtain a high-viscosity nutrient nanoemulsion; after the liquid level of the initially homogenized suspension liquid in the ingredient homogenization tank 100 reaches below the observation window 120, the first valve 410 and the vacuum pump 610 are closed in sequence, the vent valve 640 is opened, and then the second valve 510 and the unloading pump 520 are opened, and the nutrient nanoemulsion is discharged through the second valve 510 and the unloading pump 520. The particle size distribution of the nutrient nanoemulsion is shown in Table 2.

[0076]

[0077] Table 2

[0078] According to Table 2, when the cumulative particle size distribution percentage in the sample reaches 50%, the corresponding particle size is 368nm, which can characterize the average particle size of the nutrient nanoemulsion. When the cumulative particle size distribution percentage in the sample reaches 75%, the corresponding particle size is 636nm; when the cumulative particle size distribution percentage in the sample reaches 90%, the corresponding particle size is 1533nm.

[0079] Example 3

[0080] The fat-soluble nutrient is 2000g of medium-chain triglyceride; the emulsifier is 300g of soybean lecithin with a PC content of 75%; the polyol solution is a fructose solution with a gram content of 7700g (water content 2310g);

[0081] The first preset pressure is set to 5MPa; the second preset pressure is set to 0.05MPa;

[0082] 7700g of fructose solution with a water content of 2310g is added to the batching homogenizing tank 100, and then the nitrogen pressure regulating valve 210 is opened to introduce nitrogen; then the stirring device is turned on for stirring, and at the same time, 300g of soybean lecithin with a PC content of 75% is added to the batching homogenizing tank 100 to disperse the soybean lecithin in the fructose solution, and then 2000g of medium-chain triglycerides are added, and the stirring rod of the stirring device is continuously stirred at a speed of 500 rpm for 30 minutes until the materials are evenly mixed to obtain a preliminarily homogeneous suspension liquid; then the nitrogen pressure regulating valve 210 on the nitrogen pipeline 200 is adjusted to make the pressure in the batching homogenizing tank 100 reach 5MPa; then the openings of all ball valves 420 are set at full 5% of the open state; then open the vacuum pump 610 to make the pressure in the negative pressure pipe 400 and the storage tank 500 reach 0.05MPa; then open the first valve 410 to allow the preliminary homogenized suspension liquid to enter the negative pressure pipe 400 and flow through more than two ball valves 420 in sequence to finally be collected in the storage tank 500 to obtain the nutrient nanoemulsion; after the liquid level of the preliminary homogenized suspension liquid in the ingredient homogenizing tank 100 reaches below the observation window 120, close the first valve 410 and the vacuum pump 610 in sequence, open the vent valve 640, and then open the second valve 510 and the unloading pump 520, and the nutrient nanoemulsion is discharged through the second valve 510 and the unloading pump 520. The particle size distribution of the nutrient nanoemulsion is shown in Table 3.

[0083]

[0084] Table 3

[0085] According to Table 3, when the cumulative particle size distribution percentage in the sample reaches 50%, the corresponding particle size is 212nm, which can characterize the average particle size of the nutrient nanoemulsion. When the cumulative particle size distribution percentage in the sample reaches 75%, the corresponding particle size is 478nm; when the cumulative particle size distribution percentage in the sample reaches 90%, the corresponding particle size is 921nm.

[0086] Example 4

[0087] The fat-soluble nutrient is 2000g of medium-chain triglyceride; the emulsifier is 300g of soybean lecithin with a PC content of 75%; the polyol solution is a fructose solution with a gram content of 7700g (water content 2310g);

[0088] The first preset pressure is set to 2MPa; the second preset pressure is set to 0.02MPa;

[0089] 7700g of fructose solution with a water content of 2310g is added to the batching homogenizing tank 100, and then the nitrogen pressure regulating valve 210 is opened to introduce nitrogen; then the stirring device is turned on for stirring, and at the same time, 300g of soybean lecithin with a PC content of 75% is added to the batching homogenizing tank 100 to disperse the soybean lecithin in the fructose solution, and then 2000g of medium-chain triglycerides are added, and the stirring rod of the stirring device is continuously stirred at a speed of 500 rpm for 30 minutes to mix the materials evenly to obtain a preliminarily homogeneous suspension liquid; then the nitrogen pressure regulating valve 210 on the nitrogen pipeline 200 is adjusted to make the pressure in the batching homogenizing tank 100 reach 2MPa; then the openings of all ball valves 420 are set to fully open state; then open the vacuum pump 610 to make the pressure in the negative pressure pipe 400 and the storage tank 500 reach 0.02MPa; then open the first valve 410 to allow the initially homogenized suspension liquid to enter the negative pressure pipe 400 and flow through more than two ball valves 420 in sequence to finally be collected in the storage tank 500 to obtain the nutrient nanoemulsion; after the liquid level of the initially homogenized suspension liquid in the ingredient homogenizing tank 100 reaches the observation window 120, close the first valve 410 and the vacuum pump 610 in sequence, open the vent valve 640, and then open the second valve 510 and the unloading pump 520, and the nutrient nanoemulsion is discharged through the second valve 510 and the unloading pump 520. The particle size distribution of the nutrient nanoemulsion is shown in Table 4.

[0090]

[0091] Table 4

[0092] According to Table 4, when the cumulative particle size distribution percentage in the sample reaches 50%, the corresponding particle size is 297nm, which can characterize the average particle size of the nutrient nanoemulsion. When the cumulative particle size distribution percentage in the sample reaches 75%, the corresponding particle size is 692nm; when the cumulative particle size distribution percentage in the sample reaches 90%, the corresponding particle size is 1983nm.

[0093] According to Tables 1, 2, 3 and 4, for a certain mass of nutrient nanoemulsion, when the pressure difference between the first preset pressure in the ingredient homogenizing tank 100 and the second preset pressure in the storage tank 500 is larger, the particle size of the nanoemulsion is smaller, the number of particles is larger, and the particle size distribution is more uniform. The small size of the nanoparticles makes the interface diffusion more significant; at the same time, small-sized nanoparticles usually have higher colloidal stability, which is because the charge on the surface of the small particles is more evenly dispersed and is coated by the surrounding layer of solvent molecules.

[0094] According to Table 1 and Table 3, it can be seen from the particle size distribution that when the first preset pressure is 5MPa and the second preset pressure is 0.05MPa, the particle size is basically in the nanometer level. At the same time, for the opening of the three ball valves 420 of the present application, it is best to set it to 5% of the fully open state.

[0095] The nutrient nanoemulsion obtained in the present application is actually a fat-soluble nutrient emulsion premix, and the nanoemulsion has the following characteristics: all components are food raw materials; pure physical preparation process; self-cleaning system; easy to add to formula food.

[0096] The embodiments of the present application have been described above, and the above description is exemplary, not exhaustive, and is not limited to the disclosed embodiments. Many modifications and changes will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The selection of terms used herein is intended to best explain the principles of the embodiments, practical applications, or improvements to the technology in the market, or to enable other persons of ordinary skill in the art to understand the embodiments disclosed herein.

Claims

1. A system for preparing a nutrient nanoemulsion, characterized in that: include: Ingredient homogenizing tank, storage tank, stirring device, vacuum pipeline, negative pressure pipeline and nitrogen pipeline; The batching homogenizing tank is provided with an air inlet suitable for connecting with the nitrogen pipeline to introduce nitrogen into the batching homogenizing tank, and a feed inlet suitable for putting raw materials into the batching homogenizing tank; The stirring end of the stirring device is inserted into the cavity of the batching homogenizing tank; The batching homogenizing tank is also provided with a discharge port, which is connected to the inlet of the storage tank through the negative pressure pipeline; the negative pressure pipeline is provided with more than two ball valves; the more than two ball valves are arranged in sequence along the direction of material flow in the negative pressure pipeline; One end of the vacuum pipe is communicated with the interior of the cavity of the material storage tank, so that the vacuum pump extracts air from the material storage tank and the negative pressure pipe through the vacuum pipe.

2. The system for preparing the nutrient nanoemulsion according to claim 1, characterized in that: The nitrogen pipeline is provided with a nitrogen pressure regulating valve, which is suitable for regulating the pressure in the batching homogenizing tank through the nitrogen pressure regulating valve.

3. The preparation system of nutrient nanoemulsion according to claim 1, characterized in that: An observation window is arranged on the side wall of the batching homogenizing tank.

4. The system for preparing nutrient nanoemulsion according to claim 1, characterized in that: The negative pressure pipeline is provided with a first valve, and the first valve is located between the discharge port of the batching homogenizing tank and the ball valve.

5. The system for preparing nutrient nanoemulsion according to claim 1, characterized in that: The negative pressure pipeline is provided with three ball valves.

6. The system for preparing the nutrient nanoemulsion according to claim 5, characterized in that: The three ball valves are all ceramic ball valves.

7. The system for preparing nutrient nanoemulsion according to claim 1, characterized in that: One end of the negative pressure pipe that protrudes into the cavity of the material storage tank is provided with a splash shield.

8. The system for preparing nutrient nanoemulsion according to claim 1, characterized in that: The outlet of the storage tank is provided with a discharge pipe, and the discharge pipe is provided with a second valve and a discharge pump.

9. A method for preparing a nutrient nanoemulsion, characterized in that: The method is prepared by using the preparation system of the nutrient nanoemulsion according to any one of claims 1 to 8, comprising: Putting the raw materials into a nitrogen-filled ingredient homogenizing tank according to a preset procedure, wherein the raw materials include fat-soluble nutrients, emulsifiers and polyol solutions, and the ratio of the fat-soluble nutrients, the emulsifiers and the polyol solutions is a preset ratio; Controlling the stirring device to stir the original material to obtain a preliminarily homogeneous suspension liquid; The pressure in the batching homogenizing tank is adjusted to a first preset pressure, and the storage tank and the negative pressure pipeline are evacuated through the vacuum pipeline so that the pressure in the storage tank and the negative pressure pipeline reaches a second preset pressure, so that the preliminarily homogenized suspension liquid flows into the negative pressure pipeline through the discharge port of the batching homogenizing tank under the extrusion effect of pressure and is transported to the storage tank; Before the preliminarily homogenized suspension liquid flows into the negative pressure pipe through the discharge port of the batching homogenizing tank under the extrusion of pressure, the ball valve in the negative pressure pipe is controlled to reach a preset opening, so that the preliminarily homogenized suspension liquid in the negative pressure pipe is sheared and impacted by the ball valve to obtain a nutrient nanoemulsion.

10. The method for preparing the nutrient nanoemulsion according to claim 9, characterized in that: When the ball valve in the negative pressure pipeline is controlled to reach a preset opening, the openings of all the ball valves are the same.

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